Details of the Target

General Information of Target

Target ID	LDTP03540
Target Name	Heme oxygenase 2 (HMOX2)
Gene Name	HMOX2
Gene ID	3163
Synonyms	HO2; Heme oxygenase 2; HO-2; EC 1.14.14.18) [Cleaved into: Heme oxygenase 2 soluble form]
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MSAEVETSEGVDESEKKNSGALEKENQMRMADLSELLKEGTKEAHDRAENTQFVKDFLKG NIKKELFKLATTALYFTYSALEEEMERNKDHPAFAPLYFPMELHRKEALTKDMEYFFGEN WEEQVQCPKAAQKYVERIHYIGQNEPELLVAHAYTRYMGDLSGGQVLKKVAQRALKLPST GEGTQFYLFENVDNAQQFKQLYRARMNALDLNMKTKERIVEEANKAFEYNMQIFNELDQA GSTLARETLEDGFPVHDGKGDMRKCPFYAAEQDKGALEGSSCPFRTAMAVLRKPSLQFIL AAGVALAAGLLAWYYM
Target Type	Literature-reported
Target Bioclass	Enzyme
Family	Heme oxygenase family
Subcellular location	Microsome membrane
Function	[Heme oxygenase 2]: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron.; [Heme oxygenase 2 soluble form]: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron.
TTD ID	T86808
Uniprot ID	P30519
DrugMap ID	TTWZRL4
Ensemble ID	ENST00000219700.10
HGNC ID	HGNC:5014
ChEMBL ID	CHEMBL2546

Target Site Mutations in Different Cell Lines

Cell line	Mutation details	Probe for labeling this protein in this cell
LS180	SNV: p.E13G	DBIA Probe Info
MDAMB468	SNV: p.F186L	DBIA Probe Info
MOLT4	Deletion: p.G164AfsTer4	.

Probe(s) Labeling This Target

ABPP Probe

Click To Hide/Show 58 Probe Related to This Target

Probe name	Binding Site(Ratio)	Interaction ID	Ref
m-APA Probe Info	7.25	LDD0402	[2]
Alkylaryl probe 2 Probe Info	20.00	LDD0389	[3]
EN219-alkyne Probe Info	3.85	LDD0297	[4]
ILS-2 Probe Info	3.16	LDD0416	[5]
FBPP2 Probe Info	12.98	LDD0318	[6]
DA-P2 Probe Info	26.07	LDD0348	[7]
HRP Probe Info	19.53	LDD0347	[7]
CHEMBL5175495 Probe Info	13.76	LDD0196	[8]
CY-1 Probe Info	100.00	LDD0243	[9]
CY4 Probe Info	100.00	LDD0244	[9]
SAA-alkyne Probe Info	1.08	LDD0252	[10]
TG42 Probe Info	51.50	LDD0326	[11]
W1 Probe Info	22.12	LDD0235	[12]
TH211 Probe Info	Y154(20.00); Y268(13.93)	LDD0260	[13]
FBP2 Probe Info	42.55	LDD0317	[6]
TH214 Probe Info	Y154(5.19)	LDD0258	[13]
YN-1 Probe Info	100.00	LDD0444	[14]
ONAyne Probe Info	K259(4.31)	LDD0274	[15]
BTD Probe Info	C265(7.12)	LDD1699	[16]
AZ-9 Probe Info	E49(0.92); E278(1.05)	LDD2208	[17]
Alkylaryl probe 3 Probe Info	3.32	LDD0282	[18]
CCW36 Probe Info	3.65	LDD2215	[19]
JZ128-DTB Probe Info	N.A.	LDD0462	[20]
Sulforaphane-probe2 Probe Info	2.04	LDD0160	[21]
Johansson_61 Probe Info	_(8.24)	LDD1485	[22]
YY4-yne Probe Info	5.41	LDD0400	[23]
AHL-Pu-1 Probe Info	C282(2.14)	LDD0169	[24]
HPAP Probe Info	3.37	LDD0062	[25]
Alkyne-RA190 Probe Info	2.90	LDD0299	[26]
EA-probe Probe Info	C282(1.55)	LDD2210	[27]
BDBM50514113 Probe Info	3.93	LDD0041	[28]
Acrolein Probe Info	N.A.	LDD0222	[29]
DBIA Probe Info	C282(2.03)	LDD0078	[30]
ATP probe Probe Info	K259(0.00); K38(0.00); K42(0.00)	LDD0199	[31]
1d-yne Probe Info	N.A.	LDD0358	[32]
4-Iodoacetamidophenylacetylene Probe Info	C127(0.00); C282(0.00); C265(0.00)	LDD0038	[33]
IA-alkyne Probe Info	N.A.	LDD0036	[33]
Lodoacetamide azide Probe Info	C265(0.00); C127(0.00)	LDD0037	[33]
JW-RF-010 Probe Info	C282(0.00); C265(0.00)	LDD0026	[34]
NAIA_4 Probe Info	C265(0.00); C282(0.00)	LDD2226	[35]
NAIA_5 Probe Info	N.A.	LDD2224	[35]
TFBX Probe Info	N.A.	LDD0027	[34]
WYneN Probe Info	C265(0.00); C282(0.00)	LDD0021	[36]
WYneO Probe Info	N.A.	LDD0022	[36]
DA-P3 Probe Info	C265(0.00); C282(0.00)	LDD0178	[7]
aHNE Probe Info	N.A.	LDD0001	[36]
Compound 10 Probe Info	C265(0.00); C282(0.00)	LDD2216	[37]
Compound 11 Probe Info	C265(0.00); C282(0.00)	LDD2213	[37]
ENE Probe Info	C282(0.00); C265(0.00)	LDD0006	[36]
IPM Probe Info	C265(0.00); C282(0.00)	LDD0005	[36]
NHS Probe Info	K38(0.00); K168(0.00)	LDD0010	[36]
OSF Probe Info	N.A.	LDD0029	[38]
SF Probe Info	Y154(0.00); Y187(0.00)	LDD0028	[38]
STPyne Probe Info	N.A.	LDD0009	[36]
VSF Probe Info	C265(0.00); C282(0.00)	LDD0007	[36]
Phosphinate-6 Probe Info	N.A.	LDD0018	[39]
1c-yne Probe Info	K176(0.00); K199(0.00); K225(0.00)	LDD0228	[32]
AOyne Probe Info	7.30	LDD0443	[40]

PAL-AfBPP Probe

Click To Hide/Show 226 Probe Related to This Target

Probe name	Binding Site(Ratio)	Interaction ID	Ref
C001 Probe Info	11.96	LDD1711	[41]
C002 Probe Info	10.63	LDD1712	[41]
C003 Probe Info	14.03	LDD1713	[41]
C004 Probe Info	13.36	LDD1714	[41]
C007 Probe Info	23.10	LDD1716	[41]
C008 Probe Info	16.00	LDD1717	[41]
C010 Probe Info	11.16	LDD1719	[41]
C011 Probe Info	5.54	LDD1720	[41]
C017 Probe Info	7.73	LDD1725	[41]
C018 Probe Info	9.32	LDD1726	[41]
C022 Probe Info	29.04	LDD1728	[41]
C026 Probe Info	7.67	LDD1732	[41]
C027 Probe Info	10.93	LDD1733	[41]
C028 Probe Info	9.71	LDD1734	[41]
C039 Probe Info	13.18	LDD1739	[41]
C040 Probe Info	54.19	LDD1740	[41]
C041 Probe Info	46.85	LDD1741	[41]
C044 Probe Info	7.52	LDD1743	[41]
C049 Probe Info	16.91	LDD1747	[41]
C051 Probe Info	5.74	LDD1749	[41]
C052 Probe Info	7.89	LDD1750	[41]
C053 Probe Info	13.45	LDD1751	[41]
C055 Probe Info	39.67	LDD1752	[41]
C056 Probe Info	53.82	LDD1753	[41]
C063 Probe Info	35.75	LDD1760	[41]
C064 Probe Info	32.45	LDD1761	[41]
C065 Probe Info	14.42	LDD1762	[41]
C067 Probe Info	13.93	LDD1763	[41]
C070 Probe Info	62.68	LDD1766	[41]
C071 Probe Info	13.00	LDD1767	[41]
C072 Probe Info	23.26	LDD1768	[41]
C078 Probe Info	10.85	LDD1771	[41]
C082 Probe Info	12.30	LDD1774	[41]
C083 Probe Info	5.10	LDD1775	[41]
C085 Probe Info	5.94	LDD1777	[41]
C086 Probe Info	6.32	LDD1778	[41]
C087 Probe Info	35.26	LDD1779	[41]
C089 Probe Info	16.22	LDD1781	[41]
C091 Probe Info	34.54	LDD1782	[41]
C092 Probe Info	56.89	LDD1783	[41]
C094 Probe Info	80.45	LDD1785	[41]
C095 Probe Info	14.42	LDD1786	[41]
C099 Probe Info	7.52	LDD1788	[41]
C100 Probe Info	14.93	LDD1789	[41]
C106 Probe Info	67.18	LDD1793	[41]
C107 Probe Info	17.63	LDD1794	[41]
C108 Probe Info	37.27	LDD1795	[41]
C110 Probe Info	13.74	LDD1797	[41]
C112 Probe Info	71.51	LDD1799	[41]
C121 Probe Info	6.11	LDD1807	[41]
C129 Probe Info	15.56	LDD1811	[41]
C130 Probe Info	45.89	LDD1812	[41]
C134 Probe Info	70.03	LDD1816	[41]
C135 Probe Info	25.28	LDD1817	[41]
C139 Probe Info	41.36	LDD1821	[41]
C140 Probe Info	12.13	LDD1822	[41]
C141 Probe Info	15.03	LDD1823	[41]
C143 Probe Info	27.10	LDD1825	[41]
C145 Probe Info	55.72	LDD1827	[41]
C147 Probe Info	19.43	LDD1829	[41]
C153 Probe Info	42.22	LDD1834	[41]
C158 Probe Info	15.56	LDD1838	[41]
C159 Probe Info	45.89	LDD1839	[41]
C160 Probe Info	25.28	LDD1840	[41]
C161 Probe Info	53.82	LDD1841	[41]
C163 Probe Info	37.53	LDD1843	[41]
C165 Probe Info	26.72	LDD1845	[41]
C166 Probe Info	8.94	LDD1846	[41]
C169 Probe Info	99.73	LDD1849	[41]
C170 Probe Info	7.52	LDD1850	[41]
C172 Probe Info	6.87	LDD1852	[41]
C173 Probe Info	29.24	LDD1853	[41]
C174 Probe Info	8.63	LDD1854	[41]
C176 Probe Info	6.92	LDD1855	[41]
C177 Probe Info	38.59	LDD1856	[41]
C178 Probe Info	72.50	LDD1857	[41]
C183 Probe Info	22.63	LDD1861	[41]
C185 Probe Info	8.28	LDD1863	[41]
C186 Probe Info	10.70	LDD1864	[41]
C187 Probe Info	28.25	LDD1865	[41]
C191 Probe Info	21.26	LDD1868	[41]
C193 Probe Info	12.91	LDD1869	[41]
C194 Probe Info	20.39	LDD1870	[41]
C196 Probe Info	31.56	LDD1872	[41]
C198 Probe Info	21.86	LDD1874	[41]
C199 Probe Info	5.50	LDD1875	[41]
C201 Probe Info	99.73	LDD1877	[41]
C204 Probe Info	8.06	LDD1879	[41]
C205 Probe Info	11.47	LDD1880	[41]
C206 Probe Info	99.73	LDD1881	[41]
C207 Probe Info	34.06	LDD1882	[41]
C210 Probe Info	69.55	LDD1884	[41]
C211 Probe Info	41.64	LDD1885	[41]
C212 Probe Info	10.48	LDD1886	[41]
C213 Probe Info	35.51	LDD1887	[41]
C214 Probe Info	6.32	LDD1888	[41]
C216 Probe Info	8.17	LDD1890	[41]
C218 Probe Info	45.57	LDD1892	[41]
C219 Probe Info	19.29	LDD1893	[41]
C220 Probe Info	67.65	LDD1894	[41]
C222 Probe Info	6.96	LDD1896	[41]
C225 Probe Info	28.44	LDD1898	[41]
C226 Probe Info	16.22	LDD1899	[41]
C228 Probe Info	92.41	LDD1901	[41]
C229 Probe Info	33.82	LDD1902	[41]
C231 Probe Info	40.22	LDD1904	[41]
C232 Probe Info	72.50	LDD1905	[41]
C233 Probe Info	47.50	LDD1906	[41]
C234 Probe Info	19.03	LDD1907	[41]
C235 Probe Info	78.79	LDD1908	[41]
C238 Probe Info	31.56	LDD1911	[41]
C239 Probe Info	9.00	LDD1912	[41]
C240 Probe Info	30.91	LDD1913	[41]
C242 Probe Info	6.32	LDD1915	[41]
C243 Probe Info	40.50	LDD1916	[41]
C244 Probe Info	39.67	LDD1917	[41]
C246 Probe Info	30.06	LDD1919	[41]
C249 Probe Info	43.41	LDD1922	[41]
C251 Probe Info	48.50	LDD1924	[41]
C252 Probe Info	41.07	LDD1925	[41]
C255 Probe Info	27.67	LDD1928	[41]
C258 Probe Info	19.70	LDD1931	[41]
C264 Probe Info	85.04	LDD1935	[41]
C265 Probe Info	31.78	LDD1936	[41]
C266 Probe Info	11.63	LDD1937	[41]
C269 Probe Info	8.75	LDD1939	[41]
C270 Probe Info	7.62	LDD1940	[41]
C271 Probe Info	5.06	LDD1941	[41]
C272 Probe Info	20.39	LDD1942	[41]
C273 Probe Info	8.63	LDD1943	[41]
C277 Probe Info	27.10	LDD1947	[41]
C280 Probe Info	50.56	LDD1950	[41]
C282 Probe Info	52.35	LDD1952	[41]
C284 Probe Info	64.89	LDD1954	[41]
C285 Probe Info	62.25	LDD1955	[41]
C286 Probe Info	7.62	LDD1956	[41]
C287 Probe Info	51.63	LDD1957	[41]
C288 Probe Info	28.05	LDD1958	[41]
C289 Probe Info	48.50	LDD1959	[41]
C290 Probe Info	7.78	LDD1960	[41]
C292 Probe Info	8.57	LDD1962	[41]
C293 Probe Info	55.72	LDD1963	[41]
C296 Probe Info	43.71	LDD1966	[41]
C297 Probe Info	4.99	LDD1967	[41]
C299 Probe Info	18.25	LDD1968	[41]
C300 Probe Info	6.15	LDD1969	[41]
C305 Probe Info	65.34	LDD1974	[41]
C307 Probe Info	11.31	LDD1975	[41]
C310 Probe Info	14.93	LDD1977	[41]
C311 Probe Info	6.15	LDD1978	[41]
C313 Probe Info	18.77	LDD1980	[41]
C314 Probe Info	55.72	LDD1981	[41]
C317 Probe Info	13.55	LDD1983	[41]
C322 Probe Info	11.71	LDD1988	[41]
C326 Probe Info	64.45	LDD1990	[41]
C327 Probe Info	6.92	LDD1991	[41]
C338 Probe Info	20.39	LDD2001	[41]
C339 Probe Info	20.82	LDD2002	[41]
C340 Probe Info	25.99	LDD2003	[41]
C342 Probe Info	13.27	LDD2004	[41]
C343 Probe Info	27.47	LDD2005	[41]
C346 Probe Info	20.53	LDD2007	[41]
C347 Probe Info	10.34	LDD2008	[41]
C348 Probe Info	65.34	LDD2009	[41]
C349 Probe Info	75.58	LDD2010	[41]
C350 Probe Info	99.73	LDD2011	[41]
C353 Probe Info	17.03	LDD2014	[41]
C354 Probe Info	56.89	LDD2015	[41]
C355 Probe Info	99.73	LDD2016	[41]
C356 Probe Info	53.45	LDD2017	[41]
C357 Probe Info	28.05	LDD2018	[41]
C360 Probe Info	11.96	LDD2021	[41]
C361 Probe Info	61.82	LDD2022	[41]
C362 Probe Info	82.71	LDD2023	[41]
C363 Probe Info	67.18	LDD2024	[41]
C364 Probe Info	66.72	LDD2025	[41]
C366 Probe Info	61.39	LDD2027	[41]
C367 Probe Info	12.55	LDD2028	[41]
C373 Probe Info	11.39	LDD2033	[41]
C374 Probe Info	6.50	LDD2034	[41]
C376 Probe Info	28.05	LDD2036	[41]
C378 Probe Info	14.62	LDD2037	[41]
C380 Probe Info	15.35	LDD2039	[41]
C382 Probe Info	52.35	LDD2041	[41]
C383 Probe Info	77.71	LDD2042	[41]
C384 Probe Info	5.50	LDD2043	[41]
C386 Probe Info	20.53	LDD2045	[41]
C387 Probe Info	5.43	LDD2046	[41]
C388 Probe Info	99.73	LDD2047	[41]
C389 Probe Info	6.73	LDD2048	[41]
C390 Probe Info	99.73	LDD2049	[41]
C391 Probe Info	38.05	LDD2050	[41]
C396 Probe Info	7.41	LDD2055	[41]
C397 Probe Info	12.13	LDD2056	[41]
C399 Probe Info	18.77	LDD2058	[41]
C403 Probe Info	43.11	LDD2061	[41]
C405 Probe Info	16.11	LDD2063	[41]
C407 Probe Info	42.81	LDD2064	[41]
C408 Probe Info	14.32	LDD2065	[41]
C409 Probe Info	8.57	LDD2066	[41]
C413 Probe Info	69.55	LDD2069	[41]
C418 Probe Info	20.97	LDD2073	[41]
C419 Probe Info	30.27	LDD2074	[41]
C420 Probe Info	27.67	LDD2075	[41]
C424 Probe Info	17.15	LDD2079	[41]
C426 Probe Info	41.07	LDD2081	[41]
C428 Probe Info	7.36	LDD2083	[41]
C429 Probe Info	76.64	LDD2084	[41]
C430 Probe Info	10.34	LDD2085	[41]
C431 Probe Info	92.41	LDD2086	[41]
C433 Probe Info	17.75	LDD2088	[41]
FFF probe11 Probe Info	20.00	LDD0471	[42]
FFF probe13 Probe Info	20.00	LDD0475	[42]
FFF probe14 Probe Info	20.00	LDD0477	[42]
FFF probe15 Probe Info	20.00	LDD0478	[42]
FFF probe2 Probe Info	20.00	LDD0463	[42]
FFF probe3 Probe Info	20.00	LDD0464	[42]
FFF probe4 Probe Info	16.44	LDD0466	[42]
FFF probe6 Probe Info	20.00	LDD0467	[42]
FFF probe7 Probe Info	20.00	LDD0483	[42]
FFF probe9 Probe Info	20.00	LDD0485	[42]
JN0003 Probe Info	20.00	LDD0469	[42]
VE-P Probe Info	N.A.	LDD0396	[43]
A-DA Probe Info	3.42	LDD0145	[44]
Alk-rapa Probe Info	3.88	LDD0213	[45]
Probe 8 Probe Info	2.73	LDD0442	[46]

Competitor(s) Related to This Target

Competitor ID	Name	Cell line	Binding Site(Ratio)	Interaction ID	Ref
LDCM0548	1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one	MDA-MB-231	C265(0.72); C282(0.77)	LDD2142	[16]
LDCM0519	1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one	MDA-MB-231	C265(0.98); C282(2.25)	LDD2112	[16]
LDCM0502	1-(Cyanoacetyl)piperidine	MDA-MB-231	C265(0.97)	LDD2095	[16]
LDCM0537	2-Cyano-N,N-dimethylacetamide	MDA-MB-231	C265(1.01)	LDD2130	[16]
LDCM0524	2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide	MDA-MB-231	C265(1.06)	LDD2117	[16]
LDCM0558	2-Cyano-N-phenylacetamide	MDA-MB-231	C265(1.07); C282(0.98)	LDD2152	[16]
LDCM0510	3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile	MDA-MB-231	C265(1.07); C282(1.09)	LDD2103	[16]
LDCM0539	3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile	MDA-MB-231	C265(0.60)	LDD2132	[16]
LDCM0538	4-(Cyanoacetyl)morpholine	MDA-MB-231	C265(0.68)	LDD2131	[16]
LDCM0026	4SU-RNA+native RNA	HEK-293T	C282(2.14)	LDD0169	[24]
LDCM0214	AC1	HCT 116	C282(1.40); C265(1.05); C127(0.82)	LDD0531	[30]
LDCM0215	AC10	HCT 116	C282(1.74); C265(1.29); C127(0.75)	LDD0532	[30]
LDCM0216	AC100	HCT 116	C282(1.02); C265(1.10); C127(1.01)	LDD0533	[30]
LDCM0217	AC101	HCT 116	C282(0.99); C265(1.07); C127(0.94)	LDD0534	[30]
LDCM0218	AC102	HCT 116	C282(1.00); C265(1.05); C127(1.02)	LDD0535	[30]
LDCM0219	AC103	HCT 116	C282(1.63); C265(1.72); C127(0.93)	LDD0536	[30]
LDCM0220	AC104	HCT 116	C282(1.09); C265(1.14); C127(0.98)	LDD0537	[30]
LDCM0221	AC105	HCT 116	C282(1.82); C265(1.87); C127(0.96)	LDD0538	[30]
LDCM0222	AC106	HCT 116	C282(0.77); C265(0.86); C127(1.05)	LDD0539	[30]
LDCM0223	AC107	HCT 116	C282(0.93); C265(1.31); C127(1.04)	LDD0540	[30]
LDCM0224	AC108	HCT 116	C282(0.90); C265(0.95); C127(0.87)	LDD0541	[30]
LDCM0225	AC109	HCT 116	C282(1.04); C265(0.90); C127(1.00)	LDD0542	[30]
LDCM0226	AC11	HCT 116	C282(1.99); C265(1.21); C127(0.77)	LDD0543	[30]
LDCM0227	AC110	HCT 116	C282(1.02); C265(1.06); C127(0.88)	LDD0544	[30]
LDCM0228	AC111	HCT 116	C282(1.08); C265(1.16); C127(0.86)	LDD0545	[30]
LDCM0229	AC112	HCT 116	C282(1.04); C265(1.11); C127(0.87)	LDD0546	[30]
LDCM0230	AC113	HCT 116	C282(1.33); C265(1.07); C127(1.04)	LDD0547	[30]
LDCM0231	AC114	HCT 116	C282(1.46); C265(1.09); C127(0.77)	LDD0548	[30]
LDCM0232	AC115	HCT 116	C282(1.89); C265(1.18); C127(0.64)	LDD0549	[30]
LDCM0233	AC116	HCT 116	C282(1.58); C265(1.01); C127(0.62)	LDD0550	[30]
LDCM0234	AC117	HCT 116	C282(1.38); C265(0.98); C127(0.80)	LDD0551	[30]
LDCM0235	AC118	HCT 116	C282(1.26); C265(1.04); C127(0.93)	LDD0552	[30]
LDCM0236	AC119	HCT 116	C282(1.43); C265(1.10); C127(0.73)	LDD0553	[30]
LDCM0237	AC12	HCT 116	C282(1.36); C265(0.95); C127(0.92)	LDD0554	[30]
LDCM0238	AC120	HCT 116	C282(1.53); C265(1.23); C127(0.78)	LDD0555	[30]
LDCM0239	AC121	HCT 116	C282(1.39); C265(0.92); C127(0.93)	LDD0556	[30]
LDCM0240	AC122	HCT 116	C282(1.05); C265(1.27); C127(0.84)	LDD0557	[30]
LDCM0241	AC123	HCT 116	C282(1.18); C265(0.96); C127(0.98)	LDD0558	[30]
LDCM0242	AC124	HCT 116	C282(1.31); C265(0.99); C127(0.89)	LDD0559	[30]
LDCM0243	AC125	HCT 116	C282(1.40); C265(1.25); C127(0.83)	LDD0560	[30]
LDCM0244	AC126	HCT 116	C282(1.97); C265(1.11); C127(0.77)	LDD0561	[30]
LDCM0245	AC127	HCT 116	C282(1.74); C265(1.03); C127(0.79)	LDD0562	[30]
LDCM0246	AC128	HCT 116	C282(1.22); C265(1.00); C127(0.92)	LDD0563	[30]
LDCM0247	AC129	HCT 116	C282(1.01); C265(1.17); C127(1.13)	LDD0564	[30]
LDCM0249	AC130	HCT 116	C282(1.14); C265(1.22); C127(0.91)	LDD0566	[30]
LDCM0250	AC131	HCT 116	C282(1.10); C265(1.10); C127(1.14)	LDD0567	[30]
LDCM0251	AC132	HCT 116	C282(1.11); C265(1.23); C127(1.23)	LDD0568	[30]
LDCM0252	AC133	HCT 116	C282(1.17); C265(1.24); C127(1.00)	LDD0569	[30]
LDCM0253	AC134	HCT 116	C282(1.09); C265(1.44); C127(1.01)	LDD0570	[30]
LDCM0254	AC135	HCT 116	C282(1.30); C265(1.25); C127(0.95)	LDD0571	[30]
LDCM0255	AC136	HCT 116	C282(1.16); C265(1.30); C127(0.98)	LDD0572	[30]
LDCM0256	AC137	HCT 116	C282(1.12); C265(1.34); C127(1.06)	LDD0573	[30]
LDCM0257	AC138	HCT 116	C282(1.15); C265(1.65); C127(0.94)	LDD0574	[30]
LDCM0258	AC139	HCT 116	C282(1.29); C265(1.30); C127(1.05)	LDD0575	[30]
LDCM0259	AC14	HCT 116	C282(1.14); C265(0.90); C127(0.79)	LDD0576	[30]
LDCM0260	AC140	HCT 116	C282(1.43); C265(1.69); C127(0.97)	LDD0577	[30]
LDCM0261	AC141	HCT 116	C282(1.15); C265(1.72); C127(0.97)	LDD0578	[30]
LDCM0262	AC142	HCT 116	C282(1.02); C265(1.34); C127(1.21)	LDD0579	[30]
LDCM0263	AC143	HCT 116	C282(1.09); C265(1.06); C127(1.14)	LDD0580	[30]
LDCM0264	AC144	HCT 116	C127(0.67); C265(1.05); C282(1.34)	LDD0581	[30]
LDCM0265	AC145	HCT 116	C127(0.90); C265(0.97); C282(1.18)	LDD0582	[30]
LDCM0266	AC146	HCT 116	C127(0.71); C265(0.87); C282(1.32)	LDD0583	[30]
LDCM0267	AC147	HCT 116	C127(0.68); C265(0.88); C282(1.32)	LDD0584	[30]
LDCM0268	AC148	HCT 116	C127(0.74); C265(0.90); C282(1.72)	LDD0585	[30]
LDCM0269	AC149	HCT 116	C127(0.65); C265(0.84); C282(1.49)	LDD0586	[30]
LDCM0270	AC15	HCT 116	C127(0.73); C265(0.95); C282(1.17)	LDD0587	[30]
LDCM0271	AC150	HCT 116	C127(0.92); C265(1.02); C282(1.34)	LDD0588	[30]
LDCM0272	AC151	HCT 116	C127(0.74); C265(0.99); C282(1.21)	LDD0589	[30]
LDCM0273	AC152	HCT 116	C127(0.64); C265(0.91); C282(1.33)	LDD0590	[30]
LDCM0274	AC153	HCT 116	C127(0.68); C265(0.87); C282(1.77)	LDD0591	[30]
LDCM0621	AC154	HCT 116	C282(1.21); C265(0.94); C127(0.73)	LDD2158	[30]
LDCM0622	AC155	HCT 116	C282(1.44); C265(0.92); C127(0.70)	LDD2159	[30]
LDCM0623	AC156	HCT 116	C282(0.83); C265(0.86); C127(0.91)	LDD2160	[30]
LDCM0624	AC157	HCT 116	C282(0.86); C265(0.83); C127(1.09)	LDD2161	[30]
LDCM0276	AC17	HCT 116	C265(0.97); C127(1.06); C282(1.13)	LDD0593	[30]
LDCM0277	AC18	HCT 116	C127(0.74); C265(0.82); C282(1.03)	LDD0594	[30]
LDCM0278	AC19	HCT 116	C127(0.88); C265(1.00); C282(1.12)	LDD0595	[30]
LDCM0279	AC2	HCT 116	C127(0.92); C265(0.98); C282(1.16)	LDD0596	[30]
LDCM0280	AC20	HCT 116	C127(1.04); C282(1.13); C265(1.14)	LDD0597	[30]
LDCM0281	AC21	HCT 116	C265(0.85); C127(0.92); C282(1.03)	LDD0598	[30]
LDCM0282	AC22	HCT 116	C265(1.03); C282(1.10); C127(1.15)	LDD0599	[30]
LDCM0283	AC23	HCT 116	C127(1.00); C265(1.98); C282(2.62)	LDD0600	[30]
LDCM0284	AC24	HCT 116	C282(1.06); C127(1.06); C265(1.07)	LDD0601	[30]
LDCM0285	AC25	HCT 116	C127(0.92); C265(1.10); C282(1.30)	LDD0602	[30]
LDCM0286	AC26	HCT 116	C127(0.87); C265(1.12); C282(1.28)	LDD0603	[30]
LDCM0287	AC27	HCT 116	C127(0.88); C282(1.55); C265(1.68)	LDD0604	[30]
LDCM0288	AC28	HCT 116	C127(0.87); C265(1.49); C282(1.54)	LDD0605	[30]
LDCM0289	AC29	HCT 116	C127(1.05); C265(1.45); C282(1.45)	LDD0606	[30]
LDCM0290	AC3	HCT 116	C127(0.91); C265(1.00); C282(1.36)	LDD0607	[30]
LDCM0291	AC30	HCT 116	C127(0.81); C282(1.16); C265(1.20)	LDD0608	[30]
LDCM0292	AC31	HCT 116	C127(1.08); C265(1.49); C282(1.66)	LDD0609	[30]
LDCM0293	AC32	HCT 116	C127(0.69); C282(1.67); C265(1.76)	LDD0610	[30]
LDCM0294	AC33	HCT 116	C127(0.70); C282(1.57); C265(1.89)	LDD0611	[30]
LDCM0295	AC34	HCT 116	C127(0.74); C282(1.65); C265(1.99)	LDD0612	[30]
LDCM0296	AC35	HCT 116	C282(1.02); C265(1.04); C127(1.31)	LDD0613	[30]
LDCM0297	AC36	HCT 116	C282(1.07); C265(1.13); C127(1.20)	LDD0614	[30]
LDCM0298	AC37	HCT 116	C265(1.06); C127(1.07); C282(1.08)	LDD0615	[30]
LDCM0299	AC38	HCT 116	C282(1.00); C265(1.00); C127(1.04)	LDD0616	[30]
LDCM0300	AC39	HCT 116	C127(1.01); C282(1.12); C265(1.13)	LDD0617	[30]
LDCM0301	AC4	HCT 116	C127(0.91); C265(1.02); C282(1.63)	LDD0618	[30]
LDCM0302	AC40	HCT 116	C127(0.90); C265(1.53); C282(1.73)	LDD0619	[30]
LDCM0303	AC41	HCT 116	C127(1.02); C265(1.16); C282(1.18)	LDD0620	[30]
LDCM0304	AC42	HCT 116	C127(0.95); C265(1.40); C282(1.40)	LDD0621	[30]
LDCM0305	AC43	HCT 116	C127(1.06); C282(1.45); C265(1.48)	LDD0622	[30]
LDCM0306	AC44	HCT 116	C127(0.96); C282(1.28); C265(1.30)	LDD0623	[30]
LDCM0307	AC45	HCT 116	C127(0.90); C265(1.12); C282(1.19)	LDD0624	[30]
LDCM0308	AC46	HCT 116	C127(1.16); C265(1.26); C282(1.57)	LDD0625	[30]
LDCM0309	AC47	HCT 116	C127(0.99); C265(1.10); C282(1.72)	LDD0626	[30]
LDCM0310	AC48	HCT 116	C265(1.09); C127(1.13); C282(1.36)	LDD0627	[30]
LDCM0311	AC49	HCT 116	C127(0.92); C265(1.20); C282(1.30)	LDD0628	[30]
LDCM0312	AC5	HCT 116	C127(0.84); C265(0.93); C282(1.63)	LDD0629	[30]
LDCM0313	AC50	HCT 116	C127(0.91); C265(1.19); C282(1.52)	LDD0630	[30]
LDCM0314	AC51	HCT 116	C282(1.31); C265(1.32); C127(1.40)	LDD0631	[30]
LDCM0315	AC52	HCT 116	C127(1.04); C265(1.19); C282(1.40)	LDD0632	[30]
LDCM0316	AC53	HCT 116	C127(0.91); C265(1.21); C282(1.91)	LDD0633	[30]
LDCM0317	AC54	HCT 116	C127(0.93); C265(1.03); C282(1.42)	LDD0634	[30]
LDCM0318	AC55	HCT 116	C127(0.97); C265(1.20); C282(1.43)	LDD0635	[30]
LDCM0319	AC56	HCT 116	C127(1.04); C265(1.21); C282(1.64)	LDD0636	[30]
LDCM0320	AC57	HCT 116	C127(0.75); C265(1.02); C282(1.30)	LDD0637	[30]
LDCM0321	AC58	HCT 116	C127(0.73); C265(1.10); C282(1.31)	LDD0638	[30]
LDCM0322	AC59	HCT 116	C127(0.73); C265(1.07); C282(1.38)	LDD0639	[30]
LDCM0323	AC6	HCT 116	C127(0.69); C265(1.18); C282(1.46)	LDD0640	[30]
LDCM0324	AC60	HCT 116	C127(0.72); C265(1.17); C282(1.37)	LDD0641	[30]
LDCM0325	AC61	HCT 116	C127(0.68); C265(1.09); C282(1.25)	LDD0642	[30]
LDCM0326	AC62	HCT 116	C127(0.68); C265(1.05); C282(1.55)	LDD0643	[30]
LDCM0327	AC63	HCT 116	C127(0.77); C265(1.36); C282(1.72)	LDD0644	[30]
LDCM0328	AC64	HCT 116	C127(0.77); C265(1.01); C282(1.54)	LDD0645	[30]
LDCM0329	AC65	HCT 116	C127(0.73); C265(1.12); C282(1.82)	LDD0646	[30]
LDCM0330	AC66	HCT 116	C127(0.80); C265(1.04); C282(1.64)	LDD0647	[30]
LDCM0331	AC67	HCT 116	C127(0.70); C265(1.04); C282(1.81)	LDD0648	[30]
LDCM0332	AC68	HCT 116	C127(0.96); C282(1.00); C265(1.11)	LDD0649	[30]
LDCM0333	AC69	HCT 116	C127(0.90); C282(1.35); C265(1.37)	LDD0650	[30]
LDCM0334	AC7	HCT 116	C127(0.84); C265(1.42); C282(1.68)	LDD0651	[30]
LDCM0335	AC70	HCT 116	C127(0.87); C282(1.20); C265(1.33)	LDD0652	[30]
LDCM0336	AC71	HCT 116	C282(1.17); C265(1.28); C127(1.29)	LDD0653	[30]
LDCM0337	AC72	HCT 116	C127(0.94); C265(1.24); C282(1.25)	LDD0654	[30]
LDCM0338	AC73	HCT 116	C127(1.04); C265(1.56); C282(1.62)	LDD0655	[30]
LDCM0339	AC74	HCT 116	C127(1.06); C265(1.77); C282(1.77)	LDD0656	[30]
LDCM0340	AC75	HCT 116	C127(1.15); C282(2.31); C265(2.36)	LDD0657	[30]
LDCM0341	AC76	HCT 116	C127(0.97); C282(1.12); C265(1.16)	LDD0658	[30]
LDCM0342	AC77	HCT 116	C127(0.85); C282(1.26); C265(1.34)	LDD0659	[30]
LDCM0343	AC78	HCT 116	C127(0.96); C282(1.06); C265(1.12)	LDD0660	[30]
LDCM0344	AC79	HCT 116	C127(1.16); C282(1.21); C265(1.22)	LDD0661	[30]
LDCM0345	AC8	HCT 116	C127(0.81); C265(1.18); C282(1.36)	LDD0662	[30]
LDCM0346	AC80	HCT 116	C127(0.97); C265(1.05); C282(1.05)	LDD0663	[30]
LDCM0347	AC81	HCT 116	C265(0.75); C282(0.92); C127(1.31)	LDD0664	[30]
LDCM0348	AC82	HCT 116	C127(1.21); C282(2.02); C265(2.20)	LDD0665	[30]
LDCM0349	AC83	HCT 116	C127(0.70); C282(1.29); C265(1.66)	LDD0666	[30]
LDCM0350	AC84	HCT 116	C127(0.63); C282(1.15); C265(1.40)	LDD0667	[30]
LDCM0351	AC85	HCT 116	C127(0.63); C282(1.31); C265(1.37)	LDD0668	[30]
LDCM0352	AC86	HCT 116	C127(0.92); C265(1.57); C282(2.19)	LDD0669	[30]
LDCM0353	AC87	HCT 116	C127(1.01); C265(1.14); C282(1.36)	LDD0670	[30]
LDCM0354	AC88	HCT 116	C127(0.79); C265(1.33); C282(1.60)	LDD0671	[30]
LDCM0355	AC89	HCT 116	C127(0.65); C282(1.24); C265(1.34)	LDD0672	[30]
LDCM0357	AC90	HCT 116	C127(1.16); C265(1.24); C282(1.45)	LDD0674	[30]
LDCM0358	AC91	HCT 116	C127(0.77); C282(1.37); C265(1.67)	LDD0675	[30]
LDCM0359	AC92	HCT 116	C127(0.70); C282(1.30); C265(1.54)	LDD0676	[30]
LDCM0360	AC93	HCT 116	C127(0.65); C265(1.22); C282(1.37)	LDD0677	[30]
LDCM0361	AC94	HCT 116	C127(0.74); C265(1.23); C282(1.34)	LDD0678	[30]
LDCM0362	AC95	HCT 116	C127(0.91); C265(1.35); C282(1.36)	LDD0679	[30]
LDCM0363	AC96	HCT 116	C127(0.70); C265(1.36); C282(1.39)	LDD0680	[30]
LDCM0364	AC97	HCT 116	C127(0.72); C282(1.35); C265(1.57)	LDD0681	[30]
LDCM0365	AC98	HCT 116	C127(0.82); C265(1.98); C282(2.11)	LDD0682	[30]
LDCM0366	AC99	HCT 116	C127(0.98); C282(1.01); C265(1.04)	LDD0683	[30]
LDCM0545	Acetamide	MDA-MB-231	C265(0.62)	LDD2138	[16]
LDCM0520	AKOS000195272	MDA-MB-231	C265(0.41); C282(0.77)	LDD2113	[16]
LDCM0248	AKOS034007472	HCT 116	C282(1.21); C265(1.01); C127(0.94)	LDD0565	[30]
LDCM0356	AKOS034007680	HCT 116	C127(0.78); C265(1.33); C282(1.44)	LDD0673	[30]
LDCM0275	AKOS034007705	HCT 116	C127(0.62); C265(1.11); C282(1.77)	LDD0592	[30]
LDCM0156	Aniline	NCI-H1299	12.14	LDD0403	[2]
LDCM0020	ARS-1620	HCC44	C282(2.03)	LDD0078	[30]
LDCM0199	BPK-21	T cell	C282(10.89)	LDD0517	[47]
LDCM0200	BPK-25	T cell	C282(11.11)	LDD0516	[47]
LDCM0498	BS-3668	MDA-MB-231	C282(0.44)	LDD2091	[16]
LDCM0631	CCW16	231MFP	3.65	LDD2215	[19]
LDCM0630	CCW28-3	231MFP	C282(2.19); C265(1.48)	LDD2214	[19]
LDCM0108	Chloroacetamide	HeLa	N.A.	LDD0222	[29]
LDCM0632	CL-Sc	Hep-G2	C265(20.00)	LDD2227	[35]
LDCM0367	CL1	HCT 116	C127(1.45); C265(1.69); C282(7.83)	LDD0684	[30]
LDCM0368	CL10	HCT 116	C127(0.80); C282(1.27); C265(2.95)	LDD0685	[30]
LDCM0369	CL100	HCT 116	C127(0.83); C265(1.26); C282(10.99)	LDD0686	[30]
LDCM0370	CL101	HCT 116	C127(0.75); C265(1.56); C282(1.71)	LDD0687	[30]
LDCM0371	CL102	HCT 116	C127(0.83); C282(2.16); C265(3.83)	LDD0688	[30]
LDCM0372	CL103	HCT 116	C127(0.79); C265(1.71); C282(2.31)	LDD0689	[30]
LDCM0373	CL104	HCT 116	C127(0.85); C265(1.85); C282(2.00)	LDD0690	[30]
LDCM0374	CL105	HCT 116	C127(0.81); C265(2.98); C282(6.54)	LDD0691	[30]
LDCM0375	CL106	HCT 116	C127(0.88); C265(3.42); C282(9.31)	LDD0692	[30]
LDCM0376	CL107	HCT 116	C127(0.77); C265(1.40); C282(1.56)	LDD0693	[30]
LDCM0377	CL108	HCT 116	C127(0.81); C265(1.23); C282(1.54)	LDD0694	[30]
LDCM0378	CL109	HCT 116	C127(0.87); C265(2.70); C282(8.04)	LDD0695	[30]
LDCM0379	CL11	HCT 116	C127(0.86); C265(2.34); C282(16.08)	LDD0696	[30]
LDCM0380	CL110	HCT 116	C127(0.78); C265(2.87); C282(6.92)	LDD0697	[30]
LDCM0381	CL111	HCT 116	C127(0.80); C265(2.29); C282(5.82)	LDD0698	[30]
LDCM0382	CL112	HCT 116	C127(0.99); C282(2.71); C265(2.87)	LDD0699	[30]
LDCM0383	CL113	HCT 116	C127(0.75); C282(1.53); C265(1.77)	LDD0700	[30]
LDCM0384	CL114	HCT 116	C127(0.80); C265(6.26); C282(8.79)	LDD0701	[30]
LDCM0385	CL115	HCT 116	C127(0.85); C282(2.25); C265(2.58)	LDD0702	[30]
LDCM0386	CL116	HCT 116	C127(0.87); C282(1.60); C265(1.82)	LDD0703	[30]
LDCM0387	CL117	HCT 116	C127(1.02); C265(4.45); C282(5.96)	LDD0704	[30]
LDCM0388	CL118	HCT 116	C127(0.98); C265(1.60); C282(1.70)	LDD0705	[30]
LDCM0389	CL119	HCT 116	C127(0.93); C265(1.75); C282(1.78)	LDD0706	[30]
LDCM0390	CL12	HCT 116	C127(1.06); C282(1.18); C265(1.62)	LDD0707	[30]
LDCM0391	CL120	HCT 116	C127(1.15); C282(1.24); C265(1.24)	LDD0708	[30]
LDCM0392	CL121	HCT 116	C127(0.68); C265(1.05); C282(1.70)	LDD0709	[30]
LDCM0393	CL122	HCT 116	C127(0.96); C265(1.21); C282(1.58)	LDD0710	[30]
LDCM0394	CL123	HCT 116	C127(0.84); C265(2.80); C282(2.99)	LDD0711	[30]
LDCM0395	CL124	HCT 116	C127(0.90); C265(1.50); C282(3.81)	LDD0712	[30]
LDCM0396	CL125	HCT 116	C127(0.91); C265(1.29); C282(1.75)	LDD0713	[30]
LDCM0397	CL126	HCT 116	C127(0.75); C265(1.57); C282(10.30)	LDD0714	[30]
LDCM0398	CL127	HCT 116	C127(0.74); C265(1.22); C282(1.64)	LDD0715	[30]
LDCM0399	CL128	HCT 116	C127(0.72); C265(1.05); C282(1.36)	LDD0716	[30]
LDCM0400	CL13	HCT 116	C127(1.09); C265(1.56); C282(11.71)	LDD0717	[30]
LDCM0401	CL14	HCT 116	C127(1.07); C265(2.04); C282(3.52)	LDD0718	[30]
LDCM0402	CL15	HCT 116	C127(1.32); C265(2.97); C282(20.00)	LDD0719	[30]
LDCM0403	CL16	HCT 116	C127(0.64); C265(1.02); C282(2.12)	LDD0720	[30]
LDCM0404	CL17	HCT 116	C127(0.85); C265(3.51); C282(4.17)	LDD0721	[30]
LDCM0405	CL18	HCT 116	C127(0.79); C265(0.98); C282(1.31)	LDD0722	[30]
LDCM0406	CL19	HCT 116	C127(0.90); C265(0.99); C282(1.21)	LDD0723	[30]
LDCM0407	CL2	HCT 116	C265(1.21); C127(1.32); C282(16.78)	LDD0724	[30]
LDCM0408	CL20	HCT 116	C127(0.71); C265(1.00); C282(1.05)	LDD0725	[30]
LDCM0409	CL21	HCT 116	C127(0.76); C282(3.06); C265(3.46)	LDD0726	[30]
LDCM0410	CL22	HCT 116	C127(0.78); C282(0.92); C265(1.24)	LDD0727	[30]
LDCM0411	CL23	HCT 116	C127(0.70); C265(1.03); C282(1.08)	LDD0728	[30]
LDCM0412	CL24	HCT 116	C127(0.81); C265(0.99); C282(1.69)	LDD0729	[30]
LDCM0413	CL25	HCT 116	C282(5.16); C265(1.40); C127(0.87)	LDD0730	[30]
LDCM0414	CL26	HCT 116	C282(1.75); C265(1.07); C127(0.75)	LDD0731	[30]
LDCM0415	CL27	HCT 116	C282(1.53); C265(0.91); C127(0.82)	LDD0732	[30]
LDCM0416	CL28	HCT 116	C282(10.10); C265(1.11); C127(0.87)	LDD0733	[30]
LDCM0417	CL29	HCT 116	C282(1.18); C265(0.96); C127(0.74)	LDD0734	[30]
LDCM0418	CL3	HCT 116	C282(20.00); C265(1.29); C127(1.14)	LDD0735	[30]
LDCM0419	CL30	HCT 116	C282(1.26); C265(0.82); C127(0.83)	LDD0736	[30]
LDCM0420	CL31	HCT 116	C282(1.51); C265(1.64); C127(0.92)	LDD0737	[30]
LDCM0421	CL32	HCT 116	C282(1.79); C265(1.46); C127(0.57)	LDD0738	[30]
LDCM0422	CL33	HCT 116	C282(3.63); C265(3.02); C127(0.51)	LDD0739	[30]
LDCM0423	CL34	HCT 116	C282(3.80); C265(1.34); C127(0.50)	LDD0740	[30]
LDCM0424	CL35	HCT 116	C282(1.69); C265(1.25); C127(0.45)	LDD0741	[30]
LDCM0425	CL36	HCT 116	C282(1.74); C265(2.79); C127(0.45)	LDD0742	[30]
LDCM0426	CL37	HCT 116	C282(1.16); C265(1.01); C127(0.46)	LDD0743	[30]
LDCM0428	CL39	HCT 116	C282(1.58); C265(0.99); C127(0.48)	LDD0745	[30]
LDCM0429	CL4	HCT 116	C282(17.43); C265(1.15); C127(1.01)	LDD0746	[30]
LDCM0430	CL40	HCT 116	C282(1.99); C265(4.36); C127(0.51)	LDD0747	[30]
LDCM0431	CL41	HCT 116	C282(1.94); C265(1.92); C127(0.55)	LDD0748	[30]
LDCM0432	CL42	HCT 116	C282(0.81); C265(1.24); C127(0.55)	LDD0749	[30]
LDCM0433	CL43	HCT 116	C282(1.90); C265(1.22); C127(0.52)	LDD0750	[30]
LDCM0434	CL44	HCT 116	C282(3.08); C265(1.70); C127(0.46)	LDD0751	[30]
LDCM0435	CL45	HCT 116	C282(3.22); C265(5.37); C127(0.42)	LDD0752	[30]
LDCM0436	CL46	HCT 116	C282(12.47); C265(1.10); C127(1.86)	LDD0753	[30]
LDCM0437	CL47	HCT 116	C282(4.89); C265(0.92); C127(1.68)	LDD0754	[30]
LDCM0438	CL48	HCT 116	C282(5.30); C265(0.95); C127(1.71)	LDD0755	[30]
LDCM0439	CL49	HCT 116	C282(11.26); C265(0.94); C127(1.17)	LDD0756	[30]
LDCM0440	CL5	HCT 116	C282(1.69); C265(1.09); C127(1.09)	LDD0757	[30]
LDCM0441	CL50	HCT 116	C282(7.60); C265(1.15); C127(1.39)	LDD0758	[30]
LDCM0442	CL51	HCT 116	C282(0.94); C265(1.22); C127(1.58)	LDD0759	[30]
LDCM0443	CL52	HCT 116	C282(2.68); C265(1.11); C127(1.50)	LDD0760	[30]
LDCM0444	CL53	HCT 116	C282(1.02); C265(2.02); C127(1.45)	LDD0761	[30]
LDCM0445	CL54	HCT 116	C282(7.94); C265(1.59); C127(1.59)	LDD0762	[30]
LDCM0446	CL55	HCT 116	C282(2.45); C265(0.99); C127(1.69)	LDD0763	[30]
LDCM0447	CL56	HCT 116	C282(1.47); C265(1.09); C127(1.07)	LDD0764	[30]
LDCM0448	CL57	HCT 116	C282(3.83); C265(1.55); C127(1.34)	LDD0765	[30]
LDCM0449	CL58	HCT 116	C282(2.32); C265(1.02); C127(1.56)	LDD0766	[30]
LDCM0450	CL59	HCT 116	C282(2.53); C265(0.93); C127(1.18)	LDD0767	[30]
LDCM0451	CL6	HCT 116	C282(15.59); C265(2.68); C127(1.09)	LDD0768	[30]
LDCM0452	CL60	HCT 116	C282(6.34); C265(1.04); C127(1.23)	LDD0769	[30]
LDCM0453	CL61	HCT 116	C282(3.18); C265(1.24); C127(0.91)	LDD0770	[30]
LDCM0454	CL62	HCT 116	C282(2.07); C265(1.30); C127(0.81)	LDD0771	[30]
LDCM0455	CL63	HCT 116	C282(2.37); C265(1.57); C127(0.72)	LDD0772	[30]
LDCM0456	CL64	HCT 116	C282(2.31); C265(2.17); C127(0.63)	LDD0773	[30]
LDCM0457	CL65	HCT 116	C282(2.02); C265(1.31); C127(0.78)	LDD0774	[30]
LDCM0458	CL66	HCT 116	C282(3.09); C265(1.75); C127(0.53)	LDD0775	[30]
LDCM0459	CL67	HCT 116	C282(2.48); C265(1.20); C127(0.62)	LDD0776	[30]
LDCM0460	CL68	HCT 116	C282(2.29); C265(1.44); C127(0.67)	LDD0777	[30]
LDCM0461	CL69	HCT 116	C282(3.33); C265(1.64); C127(0.73)	LDD0778	[30]
LDCM0462	CL7	HCT 116	C282(20.00); C265(1.27); C127(0.93)	LDD0779	[30]
LDCM0463	CL70	HCT 116	C282(3.48); C265(1.34); C127(0.82)	LDD0780	[30]
LDCM0464	CL71	HCT 116	C282(2.90); C265(1.38); C127(0.60)	LDD0781	[30]
LDCM0465	CL72	HCT 116	C282(2.28); C265(1.26); C127(1.11)	LDD0782	[30]
LDCM0466	CL73	HCT 116	C282(2.93); C265(1.94); C127(0.67)	LDD0783	[30]
LDCM0467	CL74	HCT 116	C282(3.08); C265(1.58); C127(0.60)	LDD0784	[30]
LDCM0469	CL76	HCT 116	C282(1.83); C265(1.13); C127(0.62)	LDD0786	[30]
LDCM0470	CL77	HCT 116	C282(10.49); C265(1.45); C127(0.60)	LDD0787	[30]
LDCM0471	CL78	HCT 116	C282(4.54); C265(1.39); C127(0.49)	LDD0788	[30]
LDCM0472	CL79	HCT 116	C282(1.02); C265(0.93); C127(0.41)	LDD0789	[30]
LDCM0473	CL8	HCT 116	C282(1.87); C265(1.85); C127(0.93)	LDD0790	[30]
LDCM0474	CL80	HCT 116	C282(1.28); C265(0.88); C127(0.71)	LDD0791	[30]
LDCM0475	CL81	HCT 116	C282(3.36); C265(0.83); C127(0.55)	LDD0792	[30]
LDCM0476	CL82	HCT 116	C282(1.82); C265(0.75); C127(0.47)	LDD0793	[30]
LDCM0477	CL83	HCT 116	C282(8.59); C265(1.42); C127(0.49)	LDD0794	[30]
LDCM0478	CL84	HCT 116	C282(8.10); C265(1.38); C127(0.51)	LDD0795	[30]
LDCM0479	CL85	HCT 116	C282(2.13); C265(0.97); C127(0.49)	LDD0796	[30]
LDCM0480	CL86	HCT 116	C282(2.83); C265(1.05); C127(0.68)	LDD0797	[30]
LDCM0481	CL87	HCT 116	C282(3.70); C265(0.89); C127(0.51)	LDD0798	[30]
LDCM0482	CL88	HCT 116	C282(1.66); C265(0.88); C127(0.44)	LDD0799	[30]
LDCM0483	CL89	HCT 116	C282(3.30); C265(0.94); C127(0.58)	LDD0800	[30]
LDCM0484	CL9	HCT 116	C282(20.00); C265(1.57); C127(0.95)	LDD0801	[30]
LDCM0485	CL90	HCT 116	C282(9.57); C265(8.30); C127(1.20)	LDD0802	[30]
LDCM0486	CL91	HCT 116	C282(2.38); C265(1.10); C127(0.82)	LDD0803	[30]
LDCM0487	CL92	HCT 116	C282(10.41); C265(1.44); C127(0.91)	LDD0804	[30]
LDCM0488	CL93	HCT 116	C282(10.86); C265(1.31); C127(0.94)	LDD0805	[30]
LDCM0489	CL94	HCT 116	C282(6.51); C265(1.02); C127(0.76)	LDD0806	[30]
LDCM0490	CL95	HCT 116	C282(5.85); C265(3.05); C127(0.81)	LDD0807	[30]
LDCM0491	CL96	HCT 116	C282(6.99); C265(1.22); C127(0.83)	LDD0808	[30]
LDCM0492	CL97	HCT 116	C282(10.87); C265(1.33); C127(0.77)	LDD0809	[30]
LDCM0493	CL98	HCT 116	C282(10.91); C265(1.14); C127(0.79)	LDD0810	[30]
LDCM0494	CL99	HCT 116	C282(2.99); C265(1.28); C127(0.83)	LDD0811	[30]
LDCM0189	Compound 16	HEK-293T	40.00	LDD0492	[42]
LDCM0185	Compound 17	HEK-293T	22.73	LDD0504	[42]
LDCM0182	Compound 18	HEK-293T	12.05	LDD0501	[42]
LDCM0184	Compound 20	HEK-293T	15.15	LDD0503	[42]
LDCM0191	Compound 21	HEK-293T	7.49	LDD0493	[42]
LDCM0186	Compound 31	HEK-293T	7.66	LDD0506	[42]
LDCM0187	Compound 32	HEK-293T	20.20	LDD0507	[42]
LDCM0188	Compound 33	HEK-293T	7.78	LDD0505	[42]
LDCM0190	Compound 34	HEK-293T	8.37	LDD0497	[42]
LDCM0192	Compound 35	HEK-293T	5.21	LDD0491	[42]
LDCM0193	Compound 36	HEK-293T	8.89	LDD0494	[42]
LDCM0194	Compound 37	HEK-293T	11.17	LDD0498	[42]
LDCM0195	Compound 38	HEK-293T	14.08	LDD0499	[42]
LDCM0196	Compound 39	HEK-293T	9.52	LDD0496	[42]
LDCM0177	Compound 4	SW480	2.73	LDD0442	[46]
LDCM0197	Compound 40	HEK-293T	13.16	LDD0495	[42]
LDCM0181	Compound 41	HEK-293T	7.27	LDD0502	[42]
LDCM0183	Compound 42	HEK-293T	4.47	LDD0500	[42]
LDCM0028	Dobutamine	HEK-293T	11.82	LDD0180	[7]
LDCM0027	Dopamine	HEK-293T	7.55	LDD0179	[7]
LDCM0495	E2913	HEK-293T	C282(2.71); C265(1.58); C127(1.06)	LDD1698	[48]
LDCM0213	Electrophilic fragment 2	MDA-MB-231	C282(10.23)	LDD1702	[16]
LDCM0100	EN219	231MFP	3.89	LDD0298	[4]
LDCM0031	Epigallocatechin gallate	HEK-293T	5.42	LDD0183	[7]
LDCM0175	Ethacrynic acid	HeLa	C282(1.55)	LDD2210	[27]
LDCM0201	EV-3	T cell	C282(7.75)	LDD0515	[47]
LDCM0202	EV-93	T cell	C265(15.01); C282(12.48)	LDD0514	[47]
LDCM0203	EV-96	T cell	C282(7.17)	LDD0522	[47]
LDCM0204	EV-97	T cell	C282(16.06)	LDD0524	[47]
LDCM0205	EV-98	T cell	C282(8.57)	LDD0519	[47]
LDCM0206	EV-99	T cell	C282(20.00)	LDD0521	[47]
LDCM0625	F8	Ramos	C265(2.99); C282(5.13); 2.42	LDD2187	[49]
LDCM0572	Fragment10	Ramos	0.70	LDD2189	[49]
LDCM0573	Fragment11	Ramos	C265(0.35); 0.41	LDD2190	[49]
LDCM0575	Fragment13	Ramos	2.08	LDD2192	[49]
LDCM0576	Fragment14	Ramos	2.01	LDD2193	[49]
LDCM0580	Fragment21	Ramos	C265(2.65); 4.93	LDD2195	[49]
LDCM0582	Fragment23	Ramos	C265(0.97); C282(0.88); 0.82	LDD2196	[49]
LDCM0578	Fragment27	Ramos	C265(1.24); C282(1.30); 1.40	LDD2197	[49]
LDCM0586	Fragment28	Ramos	C265(1.79); 12.26	LDD2198	[49]
LDCM0588	Fragment30	Ramos	7.10	LDD2199	[49]
LDCM0589	Fragment31	Ramos	C265(1.13); C282(1.54); 1.77	LDD2200	[49]
LDCM0468	Fragment33	HCT 116	C282(2.99); C265(1.30); C127(0.65)	LDD0785	[30]
LDCM0596	Fragment38	Ramos	1.61	LDD2203	[49]
LDCM0566	Fragment4	Ramos	2.02	LDD2184	[49]
LDCM0427	Fragment51	HCT 116	C282(1.71); C265(11.28); C127(0.55)	LDD0744	[30]
LDCM0610	Fragment52	Ramos	2.13	LDD2204	[49]
LDCM0614	Fragment56	Ramos	C265(1.11); C282(0.84); 0.67	LDD2205	[49]
LDCM0616	Fragment61	Jurkat	_(15.07)	LDD1489	[22]
LDCM0615	Fragment63-R	Jurkat	_(14.12)	LDD1487	[22]
LDCM0617	Fragment63-S	Jurkat	_(20.00)	LDD1490	[22]
LDCM0569	Fragment7	Jurkat	_(8.24)	LDD1485	[22]
LDCM0015	HNE	MDA-MB-231	1.30	LDD0346	[49]
LDCM0179	JZ128	PC-3	N.A.	LDD0462	[20]
LDCM0022	KB02	HCT 116	C282(5.21)	LDD0080	[30]
LDCM0023	KB03	HCT 116	C282(5.00)	LDD0081	[30]
LDCM0024	KB05	HCT 116	C282(5.35)	LDD0082	[30]
LDCM0169	KB63	Ramos	5.68	LDD0432	[50]
LDCM0509	N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide	MDA-MB-231	C265(1.10)	LDD2102	[16]
LDCM0528	N-(4-bromophenyl)-2-cyano-N-phenylacetamide	MDA-MB-231	C265(0.63)	LDD2121	[16]
LDCM0496	Nucleophilic fragment 11a	MDA-MB-231	C265(0.77)	LDD2089	[16]
LDCM0497	Nucleophilic fragment 11b	MDA-MB-231	C265(1.20); C282(1.17)	LDD2090	[16]
LDCM0499	Nucleophilic fragment 12b	MDA-MB-231	C265(1.17)	LDD2092	[16]
LDCM0500	Nucleophilic fragment 13a	MDA-MB-231	C265(1.31); C282(0.99)	LDD2093	[16]
LDCM0501	Nucleophilic fragment 13b	MDA-MB-231	C265(1.23); C282(2.92)	LDD2094	[16]
LDCM0503	Nucleophilic fragment 14b	MDA-MB-231	C265(0.67); C282(0.80)	LDD2096	[16]
LDCM0504	Nucleophilic fragment 15a	MDA-MB-231	C265(1.08); C282(1.29)	LDD2097	[16]
LDCM0505	Nucleophilic fragment 15b	MDA-MB-231	C265(1.79)	LDD2098	[16]
LDCM0506	Nucleophilic fragment 16a	MDA-MB-231	C265(0.87); C282(0.89)	LDD2099	[16]
LDCM0508	Nucleophilic fragment 17a	MDA-MB-231	C265(0.44); C282(0.61)	LDD2101	[16]
LDCM0511	Nucleophilic fragment 18b	MDA-MB-231	C265(0.83); C282(1.12)	LDD2104	[16]
LDCM0512	Nucleophilic fragment 19a	MDA-MB-231	C265(1.82)	LDD2105	[16]
LDCM0513	Nucleophilic fragment 19b	MDA-MB-231	C265(0.91)	LDD2106	[16]
LDCM0514	Nucleophilic fragment 20a	MDA-MB-231	C265(0.81)	LDD2107	[16]
LDCM0515	Nucleophilic fragment 20b	MDA-MB-231	C265(0.76); C282(0.42)	LDD2108	[16]
LDCM0516	Nucleophilic fragment 21a	MDA-MB-231	C265(0.98)	LDD2109	[16]
LDCM0517	Nucleophilic fragment 21b	MDA-MB-231	C265(3.90)	LDD2110	[16]
LDCM0518	Nucleophilic fragment 22a	MDA-MB-231	C265(0.88); C282(0.86)	LDD2111	[16]
LDCM0521	Nucleophilic fragment 23b	MDA-MB-231	C265(0.65); C282(1.70)	LDD2114	[16]
LDCM0522	Nucleophilic fragment 24a	MDA-MB-231	C282(1.04)	LDD2115	[16]
LDCM0523	Nucleophilic fragment 24b	MDA-MB-231	C265(0.95)	LDD2116	[16]
LDCM0525	Nucleophilic fragment 25b	MDA-MB-231	C265(0.95)	LDD2118	[16]
LDCM0526	Nucleophilic fragment 26a	MDA-MB-231	C265(3.01); C282(2.79)	LDD2119	[16]
LDCM0527	Nucleophilic fragment 26b	MDA-MB-231	C265(0.80); C282(0.97)	LDD2120	[16]
LDCM0529	Nucleophilic fragment 27b	MDA-MB-231	C265(1.58); C282(6.87)	LDD2122	[16]
LDCM0530	Nucleophilic fragment 28a	MDA-MB-231	C265(0.75)	LDD2123	[16]
LDCM0531	Nucleophilic fragment 28b	MDA-MB-231	C265(1.02); C282(2.37)	LDD2124	[16]
LDCM0532	Nucleophilic fragment 29a	MDA-MB-231	C265(0.85)	LDD2125	[16]
LDCM0534	Nucleophilic fragment 30a	MDA-MB-231	C265(1.29); C282(1.09)	LDD2127	[16]
LDCM0535	Nucleophilic fragment 30b	MDA-MB-231	C265(1.11)	LDD2128	[16]
LDCM0536	Nucleophilic fragment 31	MDA-MB-231	C265(0.92); C282(0.68)	LDD2129	[16]
LDCM0540	Nucleophilic fragment 35	MDA-MB-231	C265(0.40); C282(1.03)	LDD2133	[16]
LDCM0541	Nucleophilic fragment 36	MDA-MB-231	C265(0.80); C282(0.75)	LDD2134	[16]
LDCM0542	Nucleophilic fragment 37	MDA-MB-231	C265(0.68); C282(0.83)	LDD2135	[16]
LDCM0543	Nucleophilic fragment 38	MDA-MB-231	C265(3.20); C282(2.36)	LDD2136	[16]
LDCM0544	Nucleophilic fragment 39	MDA-MB-231	C265(0.85); C282(1.31)	LDD2137	[16]
LDCM0211	Nucleophilic fragment 3b	MDA-MB-231	C282(1.85); C265(1.49)	LDD1700	[16]
LDCM0546	Nucleophilic fragment 40	MDA-MB-231	C265(1.13); C282(0.82)	LDD2140	[16]
LDCM0547	Nucleophilic fragment 41	MDA-MB-231	C265(0.61)	LDD2141	[16]
LDCM0549	Nucleophilic fragment 43	MDA-MB-231	C265(0.87); C282(1.89)	LDD2143	[16]
LDCM0550	Nucleophilic fragment 5a	MDA-MB-231	C265(3.47); C282(2.89)	LDD2144	[16]
LDCM0551	Nucleophilic fragment 5b	MDA-MB-231	C265(6.92); C282(4.08)	LDD2145	[16]
LDCM0552	Nucleophilic fragment 6a	MDA-MB-231	C265(0.82); C282(0.95)	LDD2146	[16]
LDCM0553	Nucleophilic fragment 6b	MDA-MB-231	C265(2.53); C282(3.15)	LDD2147	[16]
LDCM0554	Nucleophilic fragment 7a	MDA-MB-231	C265(1.00); C282(0.84)	LDD2148	[16]
LDCM0555	Nucleophilic fragment 7b	MDA-MB-231	C265(1.11)	LDD2149	[16]
LDCM0556	Nucleophilic fragment 8a	MDA-MB-231	C265(0.54)	LDD2150	[16]
LDCM0557	Nucleophilic fragment 8b	MDA-MB-231	C265(4.59)	LDD2151	[16]
LDCM0032	Oleacein	HEK-293T	15.05	LDD0184	[7]
LDCM0628	OTUB2-COV-1	HEK-293T	C265(0.86); C265(0.48); C282(0.48)	LDD2207	[51]
LDCM0014	Panhematin	HEK-293T	3.37	LDD0062	[25]
LDCM0099	Phenelzine	HEK-293T	3.32	LDD0282	[18]
LDCM0029	Quercetin	HEK-293T	12.73	LDD0181	[7]
LDCM0131	RA190	MM1.R	2.90	LDD0299	[26]
LDCM0090	Rapamycin	JHH-7	3.88	LDD0213	[45]
LDCM0084	Ro 48-8071	A-549	3.42	LDD0145	[44]
LDCM0170	Structure8	Ramos	20.00; 18.20; 8.71	LDD0433	[50]
LDCM0003	Sulforaphane	MDA-MB-231	2.04	LDD0160	[21]
LDCM0021	THZ1	HCT 116	C282(1.10)	LDD2173	[30]
LDCM0110	W12	Hep-G2	C282(14.15)	LDD0237	[12]
LDCM0111	W14	Hep-G2	C282(13.04)	LDD0238	[12]
LDCM0112	W16	Hep-G2	C282(1.50)	LDD0239	[12]
LDCM0113	W17	Hep-G2	C282(10.52)	LDD0240	[12]
LDCM0002	Ward_cp1	U2OS	3.93	LDD0041	[28]
LDCM0154	YY4	T cell	5.41	LDD0400	[23]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme

Click To Hide/Show 15 Protein(s) Interacting with This Target

Protein name	Family	Uniprot ID
DNA-directed RNA polymerase II subunit RPB9 (POLR2I)	Archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family	P36954
Bile acid-CoA:amino acid N-acyltransferase (BAAT)	C/M/P thioester hydrolase family	Q14032
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP)	EBP family	Q15125
Very long chain fatty acid elongase 4 (ELOVL4)	ELO family	Q9GZR5
Very long chain fatty acid elongase 5 (ELOVL5)	ELO family	Q9NYP7
Probable glutathione peroxidase 8 (GPX8)	Glutathione peroxidase family	Q8TED1
Sphingosine-1-phosphate lyase 1 (SGPL1)	Group II decarboxylase family	O95470
Cytochrome c oxidase assembly factor 7 (COA7)	Hcp beta-lactamase family	Q96BR5
Glutathione S-transferase 3, mitochondrial (MGST3)	MAPEG family	O14880
Tyrosine-protein kinase Fyn (FYN)	Tyr protein kinase family	P06241
Ribonuclease kappa (RNASEK)	RNase K family	Q6P5S7
ADP-ribosylation factor-like protein 13B (ARL13B)	Arf family	Q3SXY8
GTP-binding protein SAR1a (SAR1A)	SAR1 family	Q9NR31
SPRY domain-containing SOCS box protein 1 (SPSB1)	SPSB family	Q96BD6
Ubiquitin-conjugating enzyme E2 A (UBE2A)	Ubiquitin-conjugating enzyme family	P49459

Transporter and channel

Click To Hide/Show 11 Protein(s) Interacting with This Target

Protein name	Family	Uniprot ID
Amyloid-beta precursor protein (APP)	APP family	P05067
Stomatin (STOM)	Band 7/mec-2 family	P27105
Proton-coupled zinc antiporter SLC30A8 (SLC30A8)	Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	Q8IWU4
G protein-activated inward rectifier potassium channel 2 (KCNJ6)	Inward rectifier-type potassium channel family	P48051
Lysosomal-associated transmembrane protein 5 (LAPTM5)	LAPTM4/LAPTM5 transporter family	Q13571
Aquaporin-6 (AQP6)	MIP/aquaporin (TC 1.A.8) family	Q13520
Nucleoporin p54 (NUP54)	NUP54 family	Q7Z3B4
Synaptotagmin-1 (SYT1)	Synaptotagmin family	P21579
Transmembrane protein 14B (TMEM14B)	TMEM14 family	Q9NUH8
Guided entry of tail-anchored proteins factor 1 (GET1)	WRB/GET1 family	O00258
Thioredoxin-related transmembrane protein 2 (TMX2)	.	Q9Y320

GPCR

Click To Hide/Show 1 Protein(s) Interacting with This Target

Protein name				Family	Uniprot ID
Probable G-protein coupled receptor 152 (GPR152)				G-protein coupled receptor 1 family	Q8TDT2

Immunoglobulin

Click To Hide/Show 1 Protein(s) Interacting with This Target

Protein name				Family	Uniprot ID
B-cell antigen receptor complex-associated protein alpha chain (CD79A)				.	P11912

Other

Click To Hide/Show 15 Protein(s) Interacting with This Target

Protein name	Family	Uniprot ID
Bcl-2-like protein 13 (BCL2L13)	Bcl-2 family	Q9BXK5
RNA polymerase II elongation factor ELL2 (ELL2)	ELL/occludin family	O00472
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3)	ERGIC family	Q9Y282
Protein FAM209A (FAM209A)	FAM209 family	Q5JX71
Protein FAM210B, mitochondrial (FAM210B)	FAM210 family	Q96KR6
Histone H3.3C (H3-5)	Histone H3 family	Q6NXT2
Leucine-rich repeat-containing protein 56 (LRRC56)	LRRC56 family	Q8IYG6
Protein CIMAP1D (CIMAP1D)	ODF3 family	Q3SX64
Reticulophagy regulator 3 (RETREG3)	RETREG family	Q86VR2
SNW domain-containing protein 1 (SNW1)	SNW family	Q13573
Vacuolar ATPase assembly integral membrane protein VMA21 (VMA21)	VMA21 family	Q3ZAQ7
Protein C12orf4 (C12orf4)	.	Q9NQ89
Putative uncharacterized protein RUSC1-AS1 (RUSC1-AS1)	.	Q66K80
Serine-rich single-pass membrane protein 1 (SSMEM1)	.	Q8WWF3
Uncharacterized protein C3orf36 (C3orf36)	.	Q3SXR2

The Drug(s) Related To This Target

Approved

Click To Hide/Show 1 Drug(s) Interacting with This Target

Drug Name				Drug Type	External ID
Nadh				Small molecular drug	DB00157

Investigative

Click To Hide/Show 1 Drug(s) Interacting with This Target

Drug Name				Drug Type	External ID
Stannsoporfin				Small molecular drug	DB04912

References

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2	Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
3	Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
4	Chemoproteomics-enabled discovery of covalent RNF114-based degraders that mimic natural product function. Cell Chem Biol. 2021 Apr 15;28(4):559-566.e15. doi: 10.1016/j.chembiol.2021.01.005. Epub 2021 Jan 28.
5	A Chemical Proteomic Analysis of Illudin-Interacting Proteins. Chemistry. 2019 Sep 25;25(54):12644-12651. doi: 10.1002/chem.201902919. Epub 2019 Sep 3. Mass spectrometry data entry: PXD014175
6	Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1. Mass spectrometry data entry: PXD018580
7	A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16. Mass spectrometry data entry: PXD043348
8	Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
9	Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
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11	Design and synthesis of tailored human caseinolytic protease P inhibitors. Chem Commun (Camb). 2018 Aug 28;54(70):9833-9836. doi: 10.1039/c8cc05265d. Mass spectrometry data entry: PXD010277
12	Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
13	Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
14	Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
15	A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10. Mass spectrometry data entry: PXD028270
16	Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29. Mass spectrometry data entry: PXD039908 , PXD029761
17	2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
18	Activity-Based Hydrazine Probes for Protein Profiling of Electrophilic Functionality in Therapeutic Targets. ACS Cent Sci. 2021 Sep 22;7(9):1524-1534. doi: 10.1021/acscentsci.1c00616. Epub 2021 Aug 19.
19	Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
20	A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
21	Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chem Commun (Camb). 2017 May 4;53(37):5182-5185. doi: 10.1039/c6cc08797c. Mass spectrometry data entry: PXD006279
22	Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
23	A Chemical Proteomic Probe for the Mitochondrial Pyruvate Carrier Complex. Angew Chem Int Ed Engl. 2020 Mar 2;59(10):3896-3899. doi: 10.1002/anie.201914391. Epub 2020 Feb 11.
24	Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z. Mass spectrometry data entry: PXD044625
25	A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12. Mass spectrometry data entry: PXD034651
26	Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
27	Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
28	Quantitative Chemical Proteomic Profiling of Ubiquitin Specific Proteases in Intact Cancer Cells. ACS Chem Biol. 2016 Dec 16;11(12):3268-3272. doi: 10.1021/acschembio.6b00766. Epub 2016 Oct 31.
29	ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
30	Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
31	Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
32	Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
33	Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23. Mass spectrometry data entry: PXD028853
34	Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24. Mass spectrometry data entry: PXD029255
35	N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w. Mass spectrometry data entry: PXD041264
36	A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21. Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
37	Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20. Mass spectrometry data entry: PXD022279
38	Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022. Mass spectrometry data entry: PXD039931
39	DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22. Mass spectrometry data entry: PXD033004
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41	Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26. Mass spectrometry data entry: PXD041587
42	Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
43	Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
44	A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. doi: 10.1016/j.cell.2015.05.045.
45	Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
46	Target Deconvolution Efforts on Wnt Pathway Screen Reveal Dual Modulation of Oxidative Phosphorylation and SERCA2. ChemMedChem. 2017 Jun 21;12(12):917-924. doi: 10.1002/cmdc.201700028. Epub 2017 Apr 26.
47	An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
48	Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19. Mass spectrometry data entry: PXD044402
49	Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7. Mass spectrometry data entry: PXD027578
50	2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles. J Am Chem Soc. 2020 May 13;142(19):8972-8979. doi: 10.1021/jacs.0c02721. Epub 2020 Apr 29.
51	Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.

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Correspondence

Prof. Feng Zhu

Prof. Feng Ni