Details of the Probe

General Information of Probe

Probe ID
LDPC0473
Probe Name
C240
Synonyms
Z4282859734
Probe Type
PAL-AfBPP Probe
Structure
2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 327.3
Lipid-water partition coefficient (xlogp) 2.6
Rotatable Bond Count (rotbonds) 8
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 7
Chemical Identifiers
Formula
C15H16F3N3O2
IUPAC Name
3-(3-but-3-ynyldiazirin-3-yl)-N-[2-[4-(trifluoromethyl)furan-2-yl]ethyl]propanamide
Canonical SMILES
C#CCCC1(N=N1)CCC(=O)NCCC2=CC(=CO2)C(F)(F)F
InChI
InChI=1S/C15H16F3N3O2/c1-2-3-6-14(20-21-14)7-4-13(22)19-8-5-12-9-11(10-23-12)15(16,17)18/h1,9-10H,3-8H2,(H,19,22)
InChIKey
WBICFYQWTNQDAV-UHFFFAOYSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

84 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3 (OGFOD3) LDTP15132 8.22  LDD1913 
3-ketodihydrosphingosine reductase (KDSR) LDTP05476 10.41  LDD1913 
7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) LDTP10032 12.47  LDD1913 
Acetyl-CoA acetyltransferase, cytosolic (ACAT2) LDTP11321 14.83  LDD1913 
Acid ceramidase (ASAH1) LDTP05905 17.51  LDD1913 
ADP-ribosylation factor-like protein 10 (ARL10) LDTP19745 17.15  LDD1913 
Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) LDTP04437 9.06  LDD1913 
Alkyldihydroxyacetonephosphate synthase, peroxisomal (AGPS) LDTP00186 11.96  LDD1913 
Antigen peptide transporter 1 (TAP1) LDTP05408 11.39  LDD1913 
ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) LDTP06618 13.36  LDD1913 
Beta-galactosidase (GLB1) LDTP02837 18.51  LDD1913 
Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) LDTP01241 8.75  LDD1913 
CAAX prenyl protease 1 homolog (ZMPSTE24) LDTP01328 12.73  LDD1913 
Carbohydrate sulfotransferase 14 (CHST14) LDTP09096 14.93  LDD1913 
CCR4-NOT transcription complex subunit 4 (CNOT4) LDTP01640 23.10  LDD1913 
CDGSH iron-sulfur domain-containing protein 1 (CISD1) LDTP12873 8.46  LDD1913 
Ceramide synthase 2 (CERS2) LDTP10329 11.88  LDD1913 
Cytochrome b-c1 complex subunit 8 (UQCRQ) LDTP00486 14.83  LDD1913 
Cytochrome b-c1 complex subunit 9 (UQCR10) LDTP13189 14.83  LDD1913 
Cytochrome b5 type B (CYB5B) LDTP00697 30.70  LDD1913 
Cytochrome P450 20A1 (CYP20A1) LDTP17410 12.30  LDD1913 
Dehydrogenase/reductase SDR family member 7 (DHRS7) LDTP13959 8.46  LDD1913 
Delta(24)-sterol reductase (DHCR24) LDTP06375 16.22  LDD1913 
Dihydrofolate reductase (DHFR) LDTP01769 12.47  LDD1913 
DNA replication licensing factor MCM6 (MCM6) LDTP06150 9.06  LDD1913 
Dolichyldiphosphatase 1 (DOLPP1) LDTP15328 11.00  LDD1913 
E3 ubiquitin-protein ligase BRE1A (RNF20) LDTP07218 13.83  LDD1913 
E3 ubiquitin-protein ligase RNF14 (RNF14) LDTP13154 19.03  LDD1913 
Endoplasmic reticulum transmembrane helix translocase (ATP13A1) LDTP12279 11.16  LDD1913 
Exosome complex component CSL4 (EXOSC1) LDTP13968 8.63  LDD1913 
Glutaredoxin-1 (GLRX) LDTP03786 28.44  LDD1913 
Glutaredoxin-3 (GLRX3) LDTP01374 19.84  LDD1913 
Glutathione S-transferase A4 (GSTA4) LDTP00575 22.94  LDD1913 
Glutathione S-transferase Mu 2 (GSTM2) LDTP03420 12.04  LDD1913 
Glutathione S-transferase omega-1 (GSTO1) LDTP05128 17.63  LDD1913 
Heme oxygenase 1 (HMOX1) LDTP02359 22.16  LDD1913 
Heme oxygenase 2 (HMOX2) LDTP03540 30.91  LDD1913 
Holocytochrome c-type synthase (HCCS) LDTP04581 10.56  LDD1913 
Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) LDTP06787 8.88  LDD1913 
Isochorismatase domain-containing protein 1 (ISOC1) LDTP19851 9.25  LDD1913 
Leukotriene A-4 hydrolase (LTA4H) LDTP02385 16.22  LDD1913 
Lysophosphatidic acid phosphatase type 6 (ACP6) LDTP12363 11.39  LDD1913 
Lysosomal acid glucosylceramidase (GBA1) LDTP02005 18.13  LDD1913 
Lysosomal Pro-X carboxypeptidase (PRCP) LDTP04004 9.45  LDD1913 
Lysosomal protective protein (CTSA) LDTP02505 14.93  LDD1913 
Lysosomal thioesterase PPT2 (PPT2) LDTP13620 8.28  LDD1913 
Methylsterol monooxygenase 1 (MSMO1) LDTP06477 12.04  LDD1913 
Mevalonate kinase (MVK) LDTP05405 9.25  LDD1913 
N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) LDTP11273 11.96  LDD1913 
NAD(P) transhydrogenase, mitochondrial (NNT) LDTP05862 11.96  LDD1913 
NAD-capped RNA hydrolase NUDT12 (NUDT12) LDTP11081 15.78  LDD1913 
NADH dehydrogenase 1 alpha subcomplex subunit 11 (NDUFA11) LDTP08385 9.71  LDD1913 
NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) LDTP00832 13.74  LDD1913 
NADH dehydrogenase iron-sulfur protein 2, mitochondrial (NDUFS2) LDTP01168 8.40  LDD1913 
NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) LDTP01982 28.44  LDD1913 
Nicotinamide phosphoribosyltransferase (NAMPT) LDTP04051 8.51  LDD1913 
Palmitoyl-protein thioesterase 1 (PPT1) LDTP04388 15.03  LDD1913 
Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A) LDTP05029 13.00  LDD1913 
Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) LDTP14218 13.18  LDD1913 
Peptidyl-prolyl cis-trans isomerase FKBP9 (FKBP9) LDTP01562 24.93  LDD1913 
Peroxisomal leader peptide-processing protease (TYSND1) LDTP06720 10.48  LDD1913 
Phospholipase A2 group XV (PLA2G15) LDTP09088 10.41  LDD1913 
Pirin (PIR) LDTP00325 25.81  LDD1913 
Prenylcysteine oxidase 1 (PCYOX1) LDTP13282 11.08  LDD1913 
Probable serine carboxypeptidase CPVL (CPVL) LDTP15988 12.04  LDD1913 
Prostaglandin E synthase 2 (PTGES2) LDTP12040 13.74  LDD1913 
Prostaglandin reductase 3 (PTGR3) LDTP15422 28.05  LDD1913 
Proteasome subunit beta type-2 (PSMB2) LDTP04285 11.47  LDD1913 
Proteasome subunit beta type-6 (PSMB6) LDTP03418 13.36  LDD1913 
Protein-S-isoprenylcysteine O-methyltransferase (ICMT) LDTP01039 8.82  LDD1913 
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D) LDTP00907 8.63  LDD1913 
Retinoid-inducible serine carboxypeptidase (SCPEP1) LDTP16032 8.34  LDD1913 
Ribosomal protein S6 kinase alpha-3 (RPS6KA3) LDTP04471 11.31  LDD1913 
Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) LDTP15484 9.45  LDD1913 
Serum paraoxonase/arylesterase 2 (PON2) LDTP06333 30.27  LDD1913 
Signal peptidase complex catalytic subunit SEC11A (SEC11A) LDTP05066 8.22  LDD1913 
Sphingomyelin phosphodiesterase (SMPD1) LDTP02896 8.94  LDD1913 
Sphingosine-1-phosphate lyase 1 (SGPL1) LDTP01613 9.58  LDD1913 
Squalene synthase (FDFT1) LDTP03842 13.64  LDD1913 
Tripeptidyl-peptidase 1 (TPP1) LDTP00428 13.74  LDD1913 
Ubiquitin carboxyl-terminal hydrolase 11 (USP11) LDTP04456 11.71  LDD1913 
Ubiquitin carboxyl-terminal hydrolase MINDY-3 (MINDY3) LDTP12061 11.16  LDD1913 
V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) LDTP14030 8.51  LDD1913 
Very-long-chain enoyl-CoA reductase (TECR) LDTP12867 16.68  LDD1913 
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⏷ Show the Full List of 84 Enzyme
55 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Acetyl-coenzyme A transporter 1 (SLC33A1) LDTP00262 8.40  LDD1913 
Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) LDTP09328 12.38  LDD1913 
ATP synthase subunit a (MT-ATP6) LDTP01804 22.16  LDD1913 
ATP synthase subunit g, mitochondrial (ATP5MG) LDTP14511 23.43  LDD1913 
BRI3-binding protein (BRI3BP) LDTP15648 8.69  LDD1913 
Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) LDTP02724 46.85  LDD1913 
Derlin-1 (DERL1) LDTP11245 10.06  LDD1913 
ER lumen protein-retaining receptor 1 (KDELR1) LDTP03277 17.15  LDD1913 
ER membrane protein complex subunit 5 (MMGT1) LDTP08878 17.88  LDD1913 
H(+)/Cl(-) exchange transporter 7 (CLCN7) LDTP04463 8.34  LDD1913 
Lysosome membrane protein 2 (SCARB2) LDTP06034 21.56  LDD1913 
Magnesium transporter NIPA3 (NIPAL1) LDTP17362 13.83  LDD1913 
Major facilitator superfamily domain-containing protein 3 (MFSD3) LDTP18153 25.63  LDD1913 
Membrane-associated progesterone receptor component 2 (PGRMC2) LDTP00562 12.30  LDD1913 
Metaxin-1 (MTX1) LDTP05900 12.38  LDD1913 
MICOS complex subunit MIC26 (APOO) LDTP11250 8.22  LDD1913 
Mitochondrial dicarboxylate carrier (SLC25A10) LDTP13174 13.55  LDD1913 
Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) LDTP13983 9.25  LDD1913 
Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) LDTP10913 36.00  LDD1913 
Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) LDTP01059 30.48  LDD1913 
Mitochondrial import inner membrane translocase subunit Tim22 (TIMM22) LDTP14099 13.36  LDD1913 
Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23) LDTP00477 14.32  LDD1913 
Mitochondrial inner membrane protein OXA1L (OXA1L) LDTP06308 11.96  LDD1913 
Mitochondrial proton/calcium exchanger protein (LETM1) LDTP01525 8.69  LDD1913 
Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) LDTP07885 8.57  LDD1913 
Mpv17-like protein 2 (MPV17L2) LDTP14952 15.03  LDD1913 
NPC intracellular cholesterol transporter 1 (NPC1) LDTP00541 14.03  LDD1913 
Nucleoporin NDC1 (NDC1) LDTP11213 8.94  LDD1913 
Prosaposin (PSAP) LDTP02215 9.58  LDD1913 
Protein GPR107 (GPR107) LDTP07236 13.27  LDD1913 
Protein GPR108 (GPR108) LDTP12383 19.56  LDD1913 
Protein tweety homolog 3 (TTYH3) LDTP11615 13.83  LDD1913 
Putative divalent cation/proton antiporter TMEM165 (TMEM165) LDTP12207 9.06  LDD1913 
Putative lipid scramblase CLPTM1 (CLPTM1) LDTP01745 9.78  LDD1913 
Scavenger receptor class B member 1 (SCARB1) LDTP09547 19.16  LDD1913 
Sigma intracellular receptor 2 (TMEM97) LDTP06945 8.75  LDD1913 
Sigma non-opioid intracellular receptor 1 (SIGMAR1) LDTP10958 25.11  LDD1913 
Sodium-dependent neutral amino acid transporter B(0)AT2 (SLC6A15) LDTP11826 8.34  LDD1913 
Solute carrier family 25 member 32 (SLC25A32) LDTP11813 10.70  LDD1913 
StAR-related lipid transfer protein 3 (STARD3) LDTP06221 11.39  LDD1913 
STARD3 N-terminal-like protein (STARD3NL) LDTP01671 16.00  LDD1913 
Tetraspanin-3 (TSPAN3) LDTP16813 8.22  LDD1913 
Translocating chain-associated membrane protein 1 (TRAM1) LDTP06426 17.51  LDD1913 
Translocon-associated protein subunit alpha (SSR1) LDTP04033 18.51  LDD1913 
Transmembrane 9 superfamily member 3 (TM9SF3) LDTP18448 11.88  LDD1913 
Transmembrane emp24 domain-containing protein 2 (TMED2) LDTP06365 22.01  LDD1913 
Transmembrane emp24 domain-containing protein 7 (TMED7) LDTP13969 16.22  LDD1913 
Transmembrane protein 126A (TMEM126A) LDTP15948 16.22  LDD1913 
Transmembrane protein 199 (TMEM199) LDTP08881 36.25  LDD1913 
Transmembrane protein 87A (TMEM87A) LDTP15481 14.12  LDD1913 
V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) LDTP09968 12.64  LDD1913 
Voltage-dependent anion-selective channel protein 1 (VDAC1) LDTP03132 36.00  LDD1913 
Voltage-dependent anion-selective channel protein 2 (VDAC2) LDTP04071 28.25  LDD1913 
Voltage-dependent anion-selective channel protein 3 (VDAC3) LDTP13824 9.45  LDD1913 
Zinc transporter 7 (SLC30A7) LDTP09180 14.32  LDD1913 
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⏷ Show the Full List of 55 Transporter and channel
46 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) LDTP08364 10.13  LDD1913 
Apolipoprotein L2 (APOL2) LDTP11076 58.49  LDD1913 
Centrosomal protein 43 (CEP43) LDTP01652 8.28  LDD1913 
Clustered mitochondria protein homolog (CLUH) LDTP14486 14.72  LDD1913 
Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) LDTP13902 18.25  LDD1913 
Diablo IAP-binding mitochondrial protein (DIABLO) LDTP12468 9.51  LDD1913 
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) LDTP13828 20.11  LDD1913 
Golgi integral membrane protein 4 (GOLIM4) LDTP00281 15.03  LDD1913 
HEAT repeat-containing protein 3 (HEATR3) LDTP15253 26.17  LDD1913 
Hepatoma-derived growth factor-related protein 2 (HDGFL2) LDTP08081 10.78  LDD1913 
Integrator complex subunit 14 (INTS14) LDTP15834 8.69  LDD1913 
Kelch-like ECH-associated protein 1 (KEAP1) LDTP06051 15.03  LDD1913 
Kinetochore protein Spc25 (SPC25) LDTP12192 8.51  LDD1913 
Kinetochore-associated protein 1 (KNTC1) LDTP04382 10.13  LDD1913 
Large proline-rich protein BAG6 (BAG6) LDTP04094 9.99  LDD1913 
Large ribosomal subunit protein uL10m (MRPL10) LDTP08154 9.13  LDD1913 
Mini-chromosome maintenance complex-binding protein (MCMBP) LDTP11197 8.22  LDD1913 
Mitochondrial fission process protein 1 (MTFP1) LDTP16192 8.75  LDD1913 
Mitochondrial import receptor subunit TOM22 homolog (TOMM22) LDTP12565 25.63  LDD1913 
Mitochondrial import receptor subunit TOM5 homolog (TOMM5) LDTP15420 20.82  LDD1913 
Negative elongation factor C/D (NELFCD) LDTP08594 11.96  LDD1913 
Neuferricin (CYB5D2) LDTP15623 9.45  LDD1913 
Nucleobindin-1 (NUCB1) LDTP05375 11.96  LDD1913 
Nucleobindin-2 (NUCB2) LDTP05160 27.47  LDD1913 
Nucleolar protein 9 (NOP9) LDTP15283 10.27  LDD1913 
Nurim (NRM) LDTP08606 13.45  LDD1913 
Optic atrophy 3 protein (OPA3) LDTP16006 15.89  LDD1913 
Poly(U)-binding-splicing factor PUF60 (PUF60) LDTP13311 23.59  LDD1913 
Protein FAM114A2 (FAM114A2) LDTP16080 12.30  LDD1913 
Protein FAM162A (FAM162A) LDTP10056 11.88  LDD1913 
Protein LYRIC (MTDH) LDTP08224 9.58  LDD1913 
Protein unc-119 homolog B (UNC119B) LDTP00105 16.91  LDD1913 
Rab3 GTPase-activating protein catalytic subunit (RAB3GAP1) LDTP06292 9.71  LDD1913 
Reticulon-3 (RTN3) LDTP01522 21.71  LDD1913 
Reticulon-4 (RTN4) LDTP12412 9.32  LDD1913 
Small integral membrane protein 12 (SMIM12) LDTP19859 9.71  LDD1913 
Synaptogyrin-2 (SYNGR2) LDTP00859 9.32  LDD1913 
Syntaxin-10 (STX10) LDTP00986 17.88  LDD1913 
Syntaxin-18 (STX18) LDTP13086 9.92  LDD1913 
Tetraspanin-6 (TSPAN6) LDTP14458 16.80  LDD1913 
Tetratricopeptide repeat protein 38 (TTC38) LDTP19372 9.71  LDD1913 
Thioredoxin-related transmembrane protein 4 (TMX4) LDTP18373 12.64  LDD1913 
Transmembrane protein 209 (TMEM209) LDTP18272 9.32  LDD1913 
Twinfilin-1 (TWF1) LDTP05650 8.22  LDD1913 
Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) LDTP15067 15.56  LDD1913 
Wings apart-like protein homolog (WAPL) LDTP08094 9.51  LDD1913 
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⏷ Show the Full List of 46 Other

Full Information of The Labelling Profiles of This Probe

Quantification: AfBPP Probe vs Negative Probe
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
Probe:50uM; negative probe:50uM
Quantitative Method
TMT
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Peripheral blood
Disease Model
Normal
Model Name
Human normal cells (HEK-293T)
Note
Negative probe:C#CCCC1(CCC(NC)=O)N=N1
Interaction Atlas ID
 LDD1913 
Download The Altas

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587