Details of the Target

General Information of Target

Target ID LDTP01168
Target Name NADH dehydrogenase iron-sulfur protein 2, mitochondrial (NDUFS2)
Gene Name NDUFS2
Gene ID 4720
Synonyms
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial; EC 7.1.1.2; Complex I-49kD; CI-49kD; NADH-ubiquinone oxidoreductase 49 kDa subunit
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAALRALCGFRGVAAQVLRPGAGVRLPIQPSRGVRQWQPDVEWAQQFGGAVMYPSKETAH
WKPPPWNDVDPPKDTIVKNITLNFGPQHPAAHGVLRLVMELSGEMVRKCDPHIGLLHRGT
EKLIEYKTYLQALPYFDRLDYVSMMCNEQAYSLAVEKLLNIRPPPRAQWIRVLFGEITRL
LNHIMAVTTHALDLGAMTPFFWLFEEREKMFEFYERVSGARMHAAYIRPGGVHQDLPLGL
MDDIYQFSKNFSLRLDELEELLTNNRIWRNRTIDIGVVTAEEALNYGFSGVMLRGSGIQW
DLRKTQPYDVYDQVEFDVPVGSRGDCYDRYLCRVEEMRQSLRIIAQCLNKMPPGEIKVDD
AKVSPPKRAEMKTSMESLIHHFKLYTEGYQVPPGATYTAIEAPKGEFGVYLVSDGSSRPY
RCKIKAPGFAHLAGLDKMSKGHMLADVVAIIGTQDIVFGEVDR
Target Bioclass
Enzyme
Family
Complex I 49 kDa subunit family
Subcellular location
Mitochondrion inner membrane
Function
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I. Essential for the assembly of complex I. Redox-sensitive, critical component of the oxygen-sensing pathway in the pulmonary vasculature which plays a key role in acute pulmonary oxygen-sensing and hypoxic pulmonary vasoconstriction. Plays an important role in carotid body sensing of hypoxia. Essential for glia-like neural stem and progenitor cell proliferation, differentiation and subsequent oligodendrocyte or neuronal maturation.
Uniprot ID
O75306
Ensemble ID
ENST00000367993.7
HGNC ID
HGNC:7708
ChEMBL ID
CHEMBL3039

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.I80V DBIA    Probe Info 
CCK81 SNV: p.R118Ter; p.N147S; p.R254W DBIA    Probe Info 
NCIH1793 SNV: p.K78N .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		5.04  LDD0402  [1]
YN-1
 Probe Info  		100.00  LDD0444  [2]
BTD
 Probe Info  		C347(2.01)  LDD1700  [3]
Jackson_14
 Probe Info  		2.08  LDD0123  [4]
DBIA
 Probe Info  		C109(14.98)  LDD0204  [5]
ATP probe
 Probe Info  		N.A.  LDD0199  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [8]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [7]
IPM
 Probe Info  		N.A.  LDD0025  [9]
WYneO
 Probe Info  		N.A.  LDD0022  [10]
TFBX
 Probe Info  		N.A.  LDD0148  [9]
1c-yne
 Probe Info  		N.A.  LDD0228  [11]
Acrolein
 Probe Info  		H381(0.00); H380(0.00); C326(0.00); C347(0.00)  LDD0217  [12]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [12]
Methacrolein
 Probe Info  		N.A.  LDD0218  [12]
NAIA_5
 Probe Info  		N.A.  LDD2223  [13]
PAL-AfBPP Probe
Click To Hide/Show 45 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C027
 Probe Info  		5.43  LDD1733  [14]
C040
 Probe Info  		6.50  LDD1740  [14]
C130
 Probe Info  		6.68  LDD1812  [14]
C159
 Probe Info  		8.28  LDD1839  [14]
C163
 Probe Info  		6.41  LDD1843  [14]
C166
 Probe Info  		17.03  LDD1846  [14]
C196
 Probe Info  		13.74  LDD1872  [14]
C198
 Probe Info  		12.64  LDD1874  [14]
C206
 Probe Info  		19.43  LDD1881  [14]
C211
 Probe Info  		14.93  LDD1885  [14]
C213
 Probe Info  		16.80  LDD1887  [14]
C225
 Probe Info  		8.94  LDD1898  [14]
C231
 Probe Info  		13.83  LDD1904  [14]
C233
 Probe Info  		14.32  LDD1906  [14]
C235
 Probe Info  		19.03  LDD1908  [14]
C240
 Probe Info  		8.40  LDD1913  [14]
C243
 Probe Info  		11.08  LDD1916  [14]
C277
 Probe Info  		8.17  LDD1947  [14]
C278
 Probe Info  		49.52  LDD1948  [14]
C282
 Probe Info  		37.27  LDD1952  [14]
C287
 Probe Info  		10.70  LDD1957  [14]
C288
 Probe Info  		6.50  LDD1958  [14]
C289
 Probe Info  		33.82  LDD1959  [14]
C290
 Probe Info  		4.96  LDD1960  [14]
C349
 Probe Info  		9.99  LDD2010  [14]
C354
 Probe Info  		8.22  LDD2015  [14]
C356
 Probe Info  		11.55  LDD2017  [14]
C373
 Probe Info  		4.96  LDD2033  [14]
C376
 Probe Info  		6.45  LDD2036  [14]
C380
 Probe Info  		5.31  LDD2039  [14]
C382
 Probe Info  		16.34  LDD2041  [14]
C386
 Probe Info  		7.06  LDD2045  [14]
FFF probe11
 Probe Info  		16.27  LDD0471  [15]
FFF probe12
 Probe Info  		12.10  LDD0473  [15]
FFF probe13
 Probe Info  		14.62  LDD0475  [15]
FFF probe14
 Probe Info  		19.48  LDD0477  [15]
FFF probe15
 Probe Info  		5.63  LDD0478  [15]
FFF probe2
 Probe Info  		16.82  LDD0463  [15]
FFF probe3
 Probe Info  		20.00  LDD0464  [15]
FFF probe4
 Probe Info  		13.05  LDD0466  [15]
JN0003
 Probe Info  		20.00  LDD0469  [15]
STS-1
 Probe Info  		N.A.  LDD0137  [16]
STS-2
 Probe Info  		N.A.  LDD0138  [16]
A-DA
 Probe Info  		2.42  LDD0142  [17]
OEA-DA
 Probe Info  		15.05  LDD0046  [18]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C347(0.63)  LDD2142  [3]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C347(0.69); C326(1.05)  LDD2117  [3]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C347(1.51)  LDD2152  [3]
 LDCM0214  AC1 PaTu 8988t C146(0.81)  LDD1093  [19]
 LDCM0215  AC10 HEK-293T C347(1.01); C146(1.01)  LDD1508  [20]
 LDCM0226  AC11 HEK-293T C347(1.03); C146(1.16); C109(1.19)  LDD1509  [20]
 LDCM0230  AC113 HEK-293T C109(0.89)  LDD0828  [19]
 LDCM0231  AC114 HEK-293T C109(0.89)  LDD0829  [19]
 LDCM0232  AC115 HEK-293T C109(0.94)  LDD0830  [19]
 LDCM0233  AC116 HEK-293T C109(1.43)  LDD0831  [19]
 LDCM0234  AC117 HEK-293T C109(1.37)  LDD0832  [19]
 LDCM0235  AC118 HEK-293T C109(1.18)  LDD0833  [19]
 LDCM0236  AC119 HEK-293T C109(1.42)  LDD0834  [19]
 LDCM0237  AC12 HEK-293T C347(1.00); C146(0.98)  LDD1510  [20]
 LDCM0238  AC120 HEK-293T C109(1.25)  LDD0836  [19]
 LDCM0239  AC121 HEK-293T C109(1.31)  LDD0837  [19]
 LDCM0240  AC122 HEK-293T C109(1.22)  LDD0838  [19]
 LDCM0241  AC123 HEK-293T C109(1.76)  LDD0839  [19]
 LDCM0242  AC124 HEK-293T C109(1.45)  LDD0840  [19]
 LDCM0243  AC125 HEK-293T C109(1.28)  LDD0841  [19]
 LDCM0244  AC126 HEK-293T C109(1.65)  LDD0842  [19]
 LDCM0245  AC127 HEK-293T C109(1.85)  LDD0843  [19]
 LDCM0259  AC14 HEK-293T C347(1.04); C146(1.01); C109(0.95)  LDD1512  [20]
 LDCM0263  AC143 HEK-293T C109(1.33)  LDD0861  [19]
 LDCM0264  AC144 HEK-293T C109(1.27)  LDD0862  [19]
 LDCM0265  AC145 HEK-293T C109(1.25)  LDD0863  [19]
 LDCM0266  AC146 HEK-293T C109(1.46)  LDD0864  [19]
 LDCM0267  AC147 HEK-293T C109(1.40)  LDD0865  [19]
 LDCM0268  AC148 HEK-293T C109(1.21)  LDD0866  [19]
 LDCM0269  AC149 HEK-293T C109(1.09)  LDD0867  [19]
 LDCM0270  AC15 HEK-293T C347(1.11); C146(0.95)  LDD1513  [20]
 LDCM0271  AC150 HEK-293T C109(1.39)  LDD0869  [19]
 LDCM0272  AC151 HEK-293T C109(1.21)  LDD0870  [19]
 LDCM0273  AC152 HEK-293T C109(1.50)  LDD0871  [19]
 LDCM0274  AC153 HEK-293T C109(1.22)  LDD0872  [19]
 LDCM0621  AC154 HEK-293T C109(1.07)  LDD2162  [19]
 LDCM0622  AC155 HEK-293T C109(1.14)  LDD2163  [19]
 LDCM0623  AC156 HEK-293T C109(1.38)  LDD2164  [19]
 LDCM0624  AC157 HEK-293T C109(1.58)  LDD2165  [19]
 LDCM0276  AC17 HEK-293T C109(1.38)  LDD0874  [19]
 LDCM0277  AC18 HEK-293T C109(1.06)  LDD0875  [19]
 LDCM0278  AC19 HEK-293T C109(1.37)  LDD0876  [19]
 LDCM0279  AC2 PaTu 8988t C146(1.18)  LDD1158  [19]
 LDCM0280  AC20 HEK-293T C109(1.27)  LDD0878  [19]
 LDCM0281  AC21 HEK-293T C109(1.36)  LDD0879  [19]
 LDCM0282  AC22 HEK-293T C109(1.29)  LDD0880  [19]
 LDCM0283  AC23 HEK-293T C109(1.49)  LDD0881  [19]
 LDCM0284  AC24 HEK-293T C109(1.06)  LDD0882  [19]
 LDCM0285  AC25 HEK-293T C109(1.41)  LDD0883  [19]
 LDCM0286  AC26 HEK-293T C109(1.25)  LDD0884  [19]
 LDCM0287  AC27 HEK-293T C109(1.50)  LDD0885  [19]
 LDCM0288  AC28 HEK-293T C109(1.35)  LDD0886  [19]
 LDCM0289  AC29 HEK-293T C109(1.41)  LDD0887  [19]
 LDCM0290  AC3 PaTu 8988t C146(1.10)  LDD1169  [19]
 LDCM0291  AC30 HEK-293T C109(1.20)  LDD0889  [19]
 LDCM0292  AC31 HEK-293T C109(1.53)  LDD0890  [19]
 LDCM0293  AC32 HEK-293T C109(1.44)  LDD0891  [19]
 LDCM0294  AC33 HEK-293T C109(1.48)  LDD0892  [19]
 LDCM0295  AC34 HEK-293T C109(1.41)  LDD0893  [19]
 LDCM0296  AC35 HEK-293T C347(0.97); C146(1.14); C109(1.19)  LDD1535  [20]
 LDCM0297  AC36 HEK-293T C347(1.02); C146(1.02)  LDD1536  [20]
 LDCM0298  AC37 HEK-293T C347(1.11); C146(1.05)  LDD1537  [20]
 LDCM0299  AC38 HEK-293T C347(1.01); C146(0.97); C109(0.91)  LDD1538  [20]
 LDCM0300  AC39 HEK-293T C347(1.04); C146(0.98)  LDD1539  [20]
 LDCM0301  AC4 PaTu 8988t C146(0.95)  LDD1180  [19]
 LDCM0302  AC40 HEK-293T C347(1.02); C146(1.00)  LDD1541  [20]
 LDCM0303  AC41 HEK-293T C347(1.15); C146(1.02)  LDD1542  [20]
 LDCM0304  AC42 HEK-293T C347(1.02); C146(0.93)  LDD1543  [20]
 LDCM0305  AC43 HEK-293T C347(1.05); C146(1.14); C109(1.20)  LDD1544  [20]
 LDCM0306  AC44 HEK-293T C347(1.02); C146(1.03)  LDD1545  [20]
 LDCM0307  AC45 HEK-293T C347(1.01); C146(1.01)  LDD1546  [20]
 LDCM0308  AC46 HEK-293T C347(1.05); C146(1.00); C109(1.03)  LDD1547  [20]
 LDCM0309  AC47 HEK-293T C347(1.01); C146(0.99)  LDD1548  [20]
 LDCM0310  AC48 HEK-293T C347(1.02); C146(1.04)  LDD1549  [20]
 LDCM0311  AC49 HEK-293T C347(1.15); C146(1.03)  LDD1550  [20]
 LDCM0312  AC5 PaTu 8988t C146(1.04)  LDD1191  [19]
 LDCM0313  AC50 HEK-293T C347(1.02); C146(1.03)  LDD1552  [20]
 LDCM0314  AC51 HEK-293T C347(1.02); C146(1.12); C109(1.13)  LDD1553  [20]
 LDCM0315  AC52 HEK-293T C347(1.03); C146(1.03)  LDD1554  [20]
 LDCM0316  AC53 HEK-293T C347(1.01); C146(0.95)  LDD1555  [20]
 LDCM0317  AC54 HEK-293T C347(1.02); C146(1.03); C109(0.99)  LDD1556  [20]
 LDCM0318  AC55 HEK-293T C347(1.09); C146(1.03)  LDD1557  [20]
 LDCM0319  AC56 HEK-293T C347(1.01); C146(1.02)  LDD1558  [20]
 LDCM0320  AC57 HEK-293T C347(1.07); C146(1.06)  LDD1559  [20]
 LDCM0321  AC58 HEK-293T C347(1.02); C146(1.02)  LDD1560  [20]
 LDCM0322  AC59 HEK-293T C347(1.03); C146(1.20); C109(0.96)  LDD1561  [20]
 LDCM0323  AC6 HEK-293T C347(1.07); C146(0.92); C109(1.00)  LDD1562  [20]
 LDCM0324  AC60 HEK-293T C347(1.02); C146(1.00)  LDD1563  [20]
 LDCM0325  AC61 HEK-293T C347(1.03); C146(0.98)  LDD1564  [20]
 LDCM0326  AC62 HEK-293T C347(0.99); C146(1.00); C109(1.09)  LDD1565  [20]
 LDCM0327  AC63 HEK-293T C347(0.99); C146(1.06)  LDD1566  [20]
 LDCM0328  AC64 HEK-293T C347(1.04); C146(1.03)  LDD1567  [20]
 LDCM0334  AC7 HEK-293T C347(1.08); C146(0.99)  LDD1568  [20]
 LDCM0345  AC8 HEK-293T C347(1.04); C146(1.09)  LDD1569  [20]
 LDCM0349  AC83 HEK-293T C109(1.07)  LDD0947  [19]
 LDCM0350  AC84 HEK-293T C109(1.47)  LDD0948  [19]
 LDCM0351  AC85 HEK-293T C109(1.07)  LDD0949  [19]
 LDCM0352  AC86 HEK-293T C109(1.12)  LDD0950  [19]
 LDCM0353  AC87 HEK-293T C109(1.43)  LDD0951  [19]
 LDCM0354  AC88 HEK-293T C109(1.41)  LDD0952  [19]
 LDCM0355  AC89 HEK-293T C109(1.70)  LDD0953  [19]
 LDCM0357  AC90 HEK-293T C109(1.25)  LDD0955  [19]
 LDCM0358  AC91 HEK-293T C109(1.30)  LDD0956  [19]
 LDCM0359  AC92 HEK-293T C109(1.37)  LDD0957  [19]
 LDCM0360  AC93 HEK-293T C109(1.28)  LDD0958  [19]
 LDCM0361  AC94 HEK-293T C109(1.32)  LDD0959  [19]
 LDCM0362  AC95 HEK-293T C109(1.56)  LDD0960  [19]
 LDCM0363  AC96 HEK-293T C109(1.60)  LDD0961  [19]
 LDCM0364  AC97 HEK-293T C109(2.56)  LDD0962  [19]
 LDCM0248  AKOS034007472 HEK-293T C347(1.03); C146(1.00)  LDD1511  [20]
 LDCM0356  AKOS034007680 HEK-293T C347(1.06); C146(0.98)  LDD1570  [20]
 LDCM0275  AKOS034007705 HEK-293T C347(0.99); C146(1.01)  LDD1514  [20]
 LDCM0102  BDHI 8 Jurkat C109(14.98)  LDD0204  [5]
 LDCM0108  Chloroacetamide HeLa H380(0.00); C347(0.00)  LDD0222  [12]
 LDCM0367  CL1 PaTu 8988t C146(1.12)  LDD1246  [19]
 LDCM0368  CL10 PaTu 8988t C146(0.82)  LDD1247  [19]
 LDCM0369  CL100 PaTu 8988t C146(1.05)  LDD1248  [19]
 LDCM0370  CL101 HEK-293T C347(1.12); C146(1.01)  LDD1574  [20]
 LDCM0371  CL102 HEK-293T C347(0.98); C146(0.99); C109(1.07)  LDD1575  [20]
 LDCM0372  CL103 HEK-293T C347(0.96); C146(0.99)  LDD1576  [20]
 LDCM0373  CL104 HEK-293T C347(1.03); C146(0.99); C109(1.06)  LDD1577  [20]
 LDCM0374  CL105 HEK-293T C109(1.02)  LDD0972  [19]
 LDCM0375  CL106 HEK-293T C109(1.00)  LDD0973  [19]
 LDCM0376  CL107 HEK-293T C109(1.17)  LDD0974  [19]
 LDCM0377  CL108 HEK-293T C109(1.02)  LDD0975  [19]
 LDCM0378  CL109 HEK-293T C109(1.05)  LDD0976  [19]
 LDCM0379  CL11 PaTu 8988t C146(1.16)  LDD1258  [19]
 LDCM0380  CL110 HEK-293T C109(1.36)  LDD0978  [19]
 LDCM0381  CL111 HEK-293T C109(1.27)  LDD0979  [19]
 LDCM0382  CL112 HEK-293T C109(1.26)  LDD0980  [19]
 LDCM0383  CL113 HEK-293T C109(1.22)  LDD0981  [19]
 LDCM0384  CL114 HEK-293T C109(1.76)  LDD0982  [19]
 LDCM0385  CL115 HEK-293T C109(1.65)  LDD0983  [19]
 LDCM0386  CL116 HEK-293T C109(1.78)  LDD0984  [19]
 LDCM0387  CL117 HEK-293T C347(1.18); C146(1.04)  LDD1591  [20]
 LDCM0388  CL118 HEK-293T C347(0.93); C146(1.03); C109(0.96)  LDD1592  [20]
 LDCM0389  CL119 HEK-293T C347(1.04); C146(1.01)  LDD1593  [20]
 LDCM0390  CL12 PaTu 8988t C146(1.13)  LDD1269  [19]
 LDCM0391  CL120 HEK-293T C347(1.14); C146(0.94); C109(1.06)  LDD1595  [20]
 LDCM0392  CL121 HEK-293T C347(1.02); C146(1.05)  LDD1596  [20]
 LDCM0393  CL122 HEK-293T C347(1.01); C146(1.04); C109(1.08)  LDD1597  [20]
 LDCM0394  CL123 HEK-293T C347(0.96); C146(0.97)  LDD1598  [20]
 LDCM0395  CL124 HEK-293T C347(0.91); C146(0.91); C109(1.14)  LDD1599  [20]
 LDCM0396  CL125 HEK-293T C347(1.12); C146(1.02)  LDD1600  [20]
 LDCM0397  CL126 HEK-293T C347(1.04); C146(1.11); C109(1.02)  LDD1601  [20]
 LDCM0398  CL127 HEK-293T C347(0.97); C146(1.04)  LDD1602  [20]
 LDCM0399  CL128 HEK-293T C347(1.03); C146(0.98); C109(0.93)  LDD1603  [20]
 LDCM0400  CL13 PaTu 8988t C146(0.47)  LDD1279  [19]
 LDCM0401  CL14 PaTu 8988t C146(0.49)  LDD1280  [19]
 LDCM0402  CL15 PaTu 8988t C146(1.10)  LDD1281  [19]
 LDCM0403  CL16 HEK-293T C347(1.12); C146(0.91); C109(0.94)  LDD1607  [20]
 LDCM0404  CL17 HEK-293T C347(1.19); C146(1.03)  LDD1608  [20]
 LDCM0405  CL18 HEK-293T C347(1.00); C146(1.04)  LDD1609  [20]
 LDCM0406  CL19 HEK-293T C347(1.05); C146(0.85); C109(1.23)  LDD1610  [20]
 LDCM0407  CL2 PaTu 8988t C146(0.95)  LDD1286  [19]
 LDCM0408  CL20 HEK-293T C347(1.08); C146(1.01)  LDD1612  [20]
 LDCM0409  CL21 HEK-293T C347(1.01); C146(1.03)  LDD1613  [20]
 LDCM0410  CL22 HEK-293T C347(1.15); C146(0.84); C109(1.20)  LDD1614  [20]
 LDCM0411  CL23 HEK-293T C347(1.07); C146(0.63)  LDD1615  [20]
 LDCM0412  CL24 HEK-293T C347(1.10); C146(0.97)  LDD1616  [20]
 LDCM0413  CL25 HEK-293T C347(1.13); C146(1.01)  LDD1617  [20]
 LDCM0414  CL26 HEK-293T C347(0.92); C146(0.99); C109(1.00)  LDD1618  [20]
 LDCM0415  CL27 HEK-293T C347(1.01); C146(0.91)  LDD1619  [20]
 LDCM0416  CL28 HEK-293T C347(1.04); C146(0.95); C109(1.22)  LDD1620  [20]
 LDCM0417  CL29 HEK-293T C347(1.06); C146(1.00)  LDD1621  [20]
 LDCM0418  CL3 PaTu 8988t C146(0.94)  LDD1297  [19]
 LDCM0419  CL30 HEK-293T C347(1.05); C146(0.91)  LDD1623  [20]
 LDCM0420  CL31 HEK-293T C109(1.20)  LDD1018  [19]
 LDCM0421  CL32 HEK-293T C109(1.21)  LDD1019  [19]
 LDCM0422  CL33 HEK-293T C109(1.22)  LDD1020  [19]
 LDCM0423  CL34 HEK-293T C109(1.13)  LDD1021  [19]
 LDCM0424  CL35 HEK-293T C109(1.39)  LDD1022  [19]
 LDCM0425  CL36 HEK-293T C109(1.32)  LDD1023  [19]
 LDCM0426  CL37 HEK-293T C109(1.28)  LDD1024  [19]
 LDCM0428  CL39 HEK-293T C109(1.80)  LDD1026  [19]
 LDCM0429  CL4 PaTu 8988t C146(1.02)  LDD1308  [19]
 LDCM0430  CL40 HEK-293T C109(1.16)  LDD1028  [19]
 LDCM0431  CL41 HEK-293T C109(1.58)  LDD1029  [19]
 LDCM0432  CL42 HEK-293T C109(1.63)  LDD1030  [19]
 LDCM0433  CL43 HEK-293T C109(1.62)  LDD1031  [19]
 LDCM0434  CL44 HEK-293T C109(1.25)  LDD1032  [19]
 LDCM0435  CL45 HEK-293T C109(1.50)  LDD1033  [19]
 LDCM0436  CL46 PaTu 8988t C146(0.99)  LDD1315  [19]
 LDCM0437  CL47 PaTu 8988t C146(1.12)  LDD1316  [19]
 LDCM0438  CL48 PaTu 8988t C146(0.87)  LDD1317  [19]
 LDCM0439  CL49 PaTu 8988t C146(1.09)  LDD1318  [19]
 LDCM0440  CL5 PaTu 8988t C146(0.67)  LDD1319  [19]
 LDCM0441  CL50 PaTu 8988t C146(1.02)  LDD1320  [19]
 LDCM0442  CL51 PaTu 8988t C146(1.05)  LDD1321  [19]
 LDCM0443  CL52 PaTu 8988t C146(1.01)  LDD1322  [19]
 LDCM0444  CL53 PaTu 8988t C146(1.23)  LDD1323  [19]
 LDCM0445  CL54 PaTu 8988t C146(1.03)  LDD1324  [19]
 LDCM0446  CL55 PaTu 8988t C146(0.89)  LDD1325  [19]
 LDCM0447  CL56 PaTu 8988t C146(0.35)  LDD1326  [19]
 LDCM0448  CL57 PaTu 8988t C146(0.43)  LDD1327  [19]
 LDCM0449  CL58 PaTu 8988t C146(1.05)  LDD1328  [19]
 LDCM0450  CL59 PaTu 8988t C146(0.40)  LDD1329  [19]
 LDCM0451  CL6 PaTu 8988t C146(0.97)  LDD1330  [19]
 LDCM0452  CL60 PaTu 8988t C146(0.61)  LDD1331  [19]
 LDCM0453  CL61 HEK-293T C347(1.20); C146(1.05)  LDD1656  [20]
 LDCM0454  CL62 HEK-293T C347(1.03); C146(1.05); C109(1.04)  LDD1657  [20]
 LDCM0455  CL63 HEK-293T C347(0.94); C146(1.00)  LDD1658  [20]
 LDCM0456  CL64 HEK-293T C347(1.08); C146(0.83); C109(1.16)  LDD1659  [20]
 LDCM0457  CL65 HEK-293T C347(1.08); C146(0.95)  LDD1660  [20]
 LDCM0458  CL66 HEK-293T C347(1.03); C146(0.99)  LDD1661  [20]
 LDCM0459  CL67 HEK-293T C347(1.07); C146(0.82); C109(1.09)  LDD1662  [20]
 LDCM0460  CL68 HEK-293T C347(1.07); C146(0.95)  LDD1663  [20]
 LDCM0461  CL69 HEK-293T C347(1.05); C146(1.02)  LDD1664  [20]
 LDCM0462  CL7 PaTu 8988t C146(0.67)  LDD1341  [19]
 LDCM0463  CL70 HEK-293T C347(1.10); C146(0.88); C109(1.01)  LDD1666  [20]
 LDCM0464  CL71 HEK-293T C347(1.04); C146(0.67)  LDD1667  [20]
 LDCM0465  CL72 HEK-293T C347(1.03); C146(1.00)  LDD1668  [20]
 LDCM0466  CL73 HEK-293T C347(1.21); C146(1.02)  LDD1669  [20]
 LDCM0467  CL74 HEK-293T C347(1.01); C146(1.06); C109(1.00)  LDD1670  [20]
 LDCM0469  CL76 HEK-293T C347(1.13); C146(1.05); C109(1.13)  LDD1672  [20]
 LDCM0470  CL77 HEK-293T C347(1.12); C146(1.06)  LDD1673  [20]
 LDCM0471  CL78 HEK-293T C347(1.04); C146(1.02)  LDD1674  [20]
 LDCM0472  CL79 HEK-293T C347(1.03); C146(0.80); C109(1.11)  LDD1675  [20]
 LDCM0473  CL8 PaTu 8988t C146(0.80)  LDD1352  [19]
 LDCM0474  CL80 HEK-293T C347(1.09); C146(1.01)  LDD1677  [20]
 LDCM0475  CL81 HEK-293T C347(1.12); C146(1.09)  LDD1678  [20]
 LDCM0476  CL82 HEK-293T C347(1.01); C146(0.95); C109(1.39)  LDD1679  [20]
 LDCM0477  CL83 HEK-293T C347(1.08); C146(0.82)  LDD1680  [20]
 LDCM0478  CL84 HEK-293T C347(1.06); C146(0.91)  LDD1681  [20]
 LDCM0479  CL85 HEK-293T C347(1.26); C146(0.98)  LDD1682  [20]
 LDCM0480  CL86 HEK-293T C347(1.02); C146(1.20); C109(0.86)  LDD1683  [20]
 LDCM0481  CL87 HEK-293T C347(1.06); C146(1.00)  LDD1684  [20]
 LDCM0482  CL88 HEK-293T C347(1.08); C146(0.95); C109(0.89)  LDD1685  [20]
 LDCM0483  CL89 HEK-293T C347(1.21); C146(1.08)  LDD1686  [20]
 LDCM0484  CL9 PaTu 8988t C146(0.72)  LDD1363  [19]
 LDCM0485  CL90 HEK-293T C347(1.09); C146(1.12)  LDD1688  [20]
 LDCM0486  CL91 PaTu 8988t C146(1.12)  LDD1365  [19]
 LDCM0487  CL92 PaTu 8988t C146(1.09)  LDD1366  [19]
 LDCM0488  CL93 PaTu 8988t C146(1.01)  LDD1367  [19]
 LDCM0489  CL94 PaTu 8988t C146(1.04)  LDD1368  [19]
 LDCM0490  CL95 PaTu 8988t C146(1.11)  LDD1369  [19]
 LDCM0491  CL96 PaTu 8988t C146(1.11)  LDD1370  [19]
 LDCM0492  CL97 PaTu 8988t C146(1.13)  LDD1371  [19]
 LDCM0493  CL98 PaTu 8988t C146(0.98)  LDD1372  [19]
 LDCM0494  CL99 PaTu 8988t C146(1.23)  LDD1373  [19]
 LDCM0495  E2913 HEK-293T C347(1.09); C146(0.99)  LDD1698  [20]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C347(2.13)  LDD1702  [3]
 LDCM0625  F8 Ramos C326(1.62)  LDD2187  [21]
 LDCM0082  FK866 A-549 2.42  LDD0142  [17]
 LDCM0573  Fragment11 Ramos C326(0.41)  LDD2190  [21]
 LDCM0586  Fragment28 Ramos C326(0.54)  LDD2198  [21]
 LDCM0468  Fragment33 HEK-293T C347(1.07); C146(0.97)  LDD1671  [20]
 LDCM0566  Fragment4 Ramos C326(1.46)  LDD2184  [21]
 LDCM0427  Fragment51 HEK-293T C109(1.13)  LDD1025  [19]
 LDCM0569  Fragment7 Ramos C326(2.57)  LDD2186  [21]
 LDCM0107  IAA HeLa H381(0.00); H380(0.00); H233(0.00)  LDD0221  [12]
 LDCM0022  KB02 HEK-293T C347(0.99); C146(1.02)  LDD1492  [20]
 LDCM0023  KB03 Jurkat C326(146.17)  LDD0209  [5]
 LDCM0024  KB05 IGR37 C347(3.52)  LDD3314  [22]
 LDCM0109  NEM HeLa H380(0.00); H381(0.00)  LDD0223  [12]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C347(1.03)  LDD2093  [3]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C347(0.89)  LDD2097  [3]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C347(1.26); C326(1.34)  LDD2099  [3]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C326(0.87)  LDD2100  [3]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C347(0.70)  LDD2101  [3]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C326(0.73)  LDD2104  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C347(1.16)  LDD2107  [3]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C347(0.92)  LDD2108  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C347(0.42)  LDD2109  [3]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C347(1.03)  LDD2111  [3]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C326(0.79)  LDD2114  [3]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C347(0.37)  LDD2115  [3]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C347(0.15)  LDD2118  [3]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C347(2.19)  LDD2119  [3]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C347(0.08)  LDD2122  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C347(0.69)  LDD2125  [3]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C347(0.09)  LDD2126  [3]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C347(1.42)  LDD2129  [3]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C347(0.67)  LDD2134  [3]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C347(1.83)  LDD2135  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C347(1.18)  LDD2136  [3]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C347(2.01)  LDD1700  [3]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C326(0.91)  LDD2141  [3]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C347(2.24)  LDD2144  [3]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C326(5.36)  LDD2145  [3]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C347(0.46)  LDD2148  [3]
 LDCM0016  Ranjitkar_cp1 MDA-MB-231 2.08  LDD0123  [4]
 LDCM0084  Ro 48-8071 A-549 4.87  LDD0145  [17]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
NADH dehydrogenase iron-sulfur protein 3, mitochondrial (NDUFS3) Complex I 30 kDa subunit family O75489
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Oncostatin-M-specific receptor subunit beta (OSMR) Type I cytokine receptor family Q99650

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Doxorubicin Small molecular drug DB00997
Nadh Small molecular drug DB00157

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
5 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
15 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
16 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
17 A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. doi: 10.1016/j.cell.2015.05.045.
18 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
19 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
20 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
21 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
22 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840