Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C240  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 84 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03540  Heme oxygenase 2 (HMOX2) 30.9
 LDTP00697  Cytochrome b5 type B (CYB5B) 30.7
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 30.3
 LDTP03786  Glutaredoxin-1 (GLRX) 28.4
 LDTP01982  NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) 28.4
 LDTP15422  Prostaglandin reductase 3 (PTGR3) 28.1
 LDTP00325  Pirin (PIR) 25.8
 LDTP01562  Peptidyl-prolyl cis-trans isomerase FKBP9 (FKBP9) 24.9
 LDTP01640  CCR4-NOT transcription complex subunit 4 (CNOT4) 23.1
 LDTP00575  Glutathione S-transferase A4 (GSTA4) 22.9
 LDTP02359  Heme oxygenase 1 (HMOX1) 22.2
 LDTP01374  Glutaredoxin-3 (GLRX3) 19.8
 LDTP13154  E3 ubiquitin-protein ligase RNF14 (RNF14) 19.0
 LDTP02837  Beta-galactosidase (GLB1) 18.5
 LDTP02005  Lysosomal acid glucosylceramidase (GBA1) 18.1
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) 17.6
 LDTP05905  Acid ceramidase (ASAH1) 17.5
 LDTP19745  ADP-ribosylation factor-like protein 10 (ARL10) 17.1
 LDTP12867  Very-long-chain enoyl-CoA reductase (TECR) 16.7
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 16.2
 LDTP02385  Leukotriene A-4 hydrolase (LTA4H) 16.2
 LDTP11081  NAD-capped RNA hydrolase NUDT12 (NUDT12) 15.8
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 15.0
 LDTP09096  Carbohydrate sulfotransferase 14 (CHST14) 14.9
 LDTP02505  Lysosomal protective protein (CTSA) 14.9
 LDTP11321  Acetyl-CoA acetyltransferase, cytosolic (ACAT2) 14.8
 LDTP00486  Cytochrome b-c1 complex subunit 8 (UQCRQ) 14.8
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 14.8
 LDTP07218  E3 ubiquitin-protein ligase BRE1A (RNF20) 13.8
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 13.7
 LDTP12040  Prostaglandin E synthase 2 (PTGES2) 13.7
 LDTP00428  Tripeptidyl-peptidase 1 (TPP1) 13.7
 LDTP03842  Squalene synthase (FDFT1) 13.6
 LDTP06618  ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) 13.4
 LDTP03418  Proteasome subunit beta type-6 (PSMB6) 13.4
 LDTP14218  Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) 13.2
 LDTP05029  Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A) 13.0
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 12.7
 LDTP10032  7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) 12.5
 LDTP01769  Dihydrofolate reductase (DHFR) 12.5
 LDTP17410  Cytochrome P450 20A1 (CYP20A1) 12.3
 LDTP03420  Glutathione S-transferase Mu 2 (GSTM2) 12.0
 LDTP06477  Methylsterol monooxygenase 1 (MSMO1) 12.0
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 12.0
 LDTP00186  Alkyldihydroxyacetonephosphate synthase, peroxisomal (AGPS) 12.0
 LDTP11273  N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) 12.0
 LDTP05862  NAD(P) transhydrogenase, mitochondrial (NNT) 12.0
 LDTP10329  Ceramide synthase 2 (CERS2) 11.9
 LDTP04456  Ubiquitin carboxyl-terminal hydrolase 11 (USP11) 11.7
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 11.5
 LDTP05408  Antigen peptide transporter 1 (TAP1) 11.4
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 11.4
 LDTP04471  Ribosomal protein S6 kinase alpha-3 (RPS6KA3) 11.3
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 11.2
 LDTP12061  Ubiquitin carboxyl-terminal hydrolase MINDY-3 (MINDY3) 11.2
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 11.1
 LDTP15328  Dolichyldiphosphatase 1 (DOLPP1) 11.0
 LDTP04581  Holocytochrome c-type synthase (HCCS) 10.6
 LDTP06720  Peroxisomal leader peptide-processing protease (TYSND1) 10.5
 LDTP05476  3-ketodihydrosphingosine reductase (KDSR) 10.4
 LDTP09088  Phospholipase A2 group XV (PLA2G15) 10.4
 LDTP08385  NADH dehydrogenase 1 alpha subcomplex subunit 11 (NDUFA11) 9.7
 LDTP01613  Sphingosine-1-phosphate lyase 1 (SGPL1) 9.6
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 9.4
 LDTP15484  Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) 9.4
 LDTP19851  Isochorismatase domain-containing protein 1 (ISOC1) 9.3
 LDTP05405  Mevalonate kinase (MVK) 9.3
 LDTP04437  Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) 9.1
 LDTP06150  DNA replication licensing factor MCM6 (MCM6) 9.1
 LDTP02896  Sphingomyelin phosphodiesterase (SMPD1) 8.9
 LDTP06787  Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) 8.9
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 8.8
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 8.8
 LDTP13968  Exosome complex component CSL4 (EXOSC1) 8.6
 LDTP00907  Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D) 8.6
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 8.5
 LDTP14030  V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) 8.5
 LDTP12873  CDGSH iron-sulfur domain-containing protein 1 (CISD1) 8.5
 LDTP13959  Dehydrogenase/reductase SDR family member 7 (DHRS7) 8.5
 LDTP01168  NADH dehydrogenase iron-sulfur protein 2, mitochondrial (NDUFS2) 8.4
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 8.3
 LDTP13620  Lysosomal thioesterase PPT2 (PPT2) 8.3
 LDTP15132  2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3 (OGFOD3) 8.2
 LDTP05066  Signal peptidase complex catalytic subunit SEC11A (SEC11A) 8.2
Transporter and channel
Click to Show/Hide to Show 55 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 46.9
 LDTP08881  Transmembrane protein 199 (TMEM199) 36.3
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 36.0
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 36.0
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 30.5
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 28.2
 LDTP18153  Major facilitator superfamily domain-containing protein 3 (MFSD3) 25.6
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 25.1
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 23.4
 LDTP01804  ATP synthase subunit a (MT-ATP6) 22.2
 LDTP06365  Transmembrane emp24 domain-containing protein 2 (TMED2) 22.0
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 21.6
 LDTP12383  Protein GPR108 (GPR108) 19.6
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 19.2
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 18.5
 LDTP08878  ER membrane protein complex subunit 5 (MMGT1) 17.9
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 17.5
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 17.1
 LDTP13969  Transmembrane emp24 domain-containing protein 7 (TMED7) 16.2
 LDTP15948  Transmembrane protein 126A (TMEM126A) 16.2
 LDTP01671  STARD3 N-terminal-like protein (STARD3NL) 16.0
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 15.0
 LDTP00477  Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23) 14.3
 LDTP09180  Zinc transporter 7 (SLC30A7) 14.3
 LDTP15481  Transmembrane protein 87A (TMEM87A) 14.1
 LDTP00541  NPC intracellular cholesterol transporter 1 (NPC1) 14.0
 LDTP17362  Magnesium transporter NIPA3 (NIPAL1) 13.8
 LDTP11615  Protein tweety homolog 3 (TTYH3) 13.8
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 13.5
 LDTP14099  Mitochondrial import inner membrane translocase subunit Tim22 (TIMM22) 13.4
 LDTP07236  Protein GPR107 (GPR107) 13.3
 LDTP09968  V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) 12.6
 LDTP09328  Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) 12.4
 LDTP05900  Metaxin-1 (MTX1) 12.4
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 12.3
 LDTP06308  Mitochondrial inner membrane protein OXA1L (OXA1L) 12.0
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 11.9
 LDTP06221  StAR-related lipid transfer protein 3 (STARD3) 11.4
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 10.7
 LDTP11245  Derlin-1 (DERL1) 10.1
 LDTP01745  Putative lipid scramblase CLPTM1 (CLPTM1) 9.8
 LDTP02215  Prosaposin (PSAP) 9.6
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) 9.4
 LDTP13983  Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) 9.3
 LDTP12207  Putative divalent cation/proton antiporter TMEM165 (TMEM165) 9.1
 LDTP11213  Nucleoporin NDC1 (NDC1) 8.9
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 8.8
 LDTP15648  BRI3-binding protein (BRI3BP) 8.7
 LDTP01525  Mitochondrial proton/calcium exchanger protein (LETM1) 8.7
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 8.6
 LDTP00262  Acetyl-coenzyme A transporter 1 (SLC33A1) 8.4
 LDTP04463  H(+)/Cl(-) exchange transporter 7 (CLCN7) 8.3
 LDTP11826  Sodium-dependent neutral amino acid transporter B(0)AT2 (SLC6A15) 8.3
 LDTP11250  MICOS complex subunit MIC26 (APOO) 8.2
 LDTP16813  Tetraspanin-3 (TSPAN3) 8.2
Other
Click to Show/Hide to Show 46 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP11076  Apolipoprotein L2 (APOL2) 58.5
 LDTP05160  Nucleobindin-2 (NUCB2) 27.5
 LDTP15253  HEAT repeat-containing protein 3 (HEATR3) 26.2
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 25.6
 LDTP13311  Poly(U)-binding-splicing factor PUF60 (PUF60) 23.6
 LDTP01522  Reticulon-3 (RTN3) 21.7
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 20.8
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 20.1
 LDTP13902  Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) 18.3
 LDTP00986  Syntaxin-10 (STX10) 17.9
 LDTP00105  Protein unc-119 homolog B (UNC119B) 16.9
 LDTP14458  Tetraspanin-6 (TSPAN6) 16.8
 LDTP16006  Optic atrophy 3 protein (OPA3) 15.9
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 15.6
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 15.0
 LDTP06051  Kelch-like ECH-associated protein 1 (KEAP1) 15.0
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 14.7
 LDTP08606  Nurim (NRM) 13.5
 LDTP18373  Thioredoxin-related transmembrane protein 4 (TMX4) 12.6
 LDTP16080  Protein FAM114A2 (FAM114A2) 12.3
 LDTP08594  Negative elongation factor C/D (NELFCD) 12.0
 LDTP05375  Nucleobindin-1 (NUCB1) 12.0
 LDTP10056  Protein FAM162A (FAM162A) 11.9
 LDTP08081  Hepatoma-derived growth factor-related protein 2 (HDGFL2) 10.8
 LDTP15283  Nucleolar protein 9 (NOP9) 10.3
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 10.1
 LDTP04382  Kinetochore-associated protein 1 (KNTC1) 10.1
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 10.0
 LDTP13086  Syntaxin-18 (STX18) 9.9
 LDTP06292  Rab3 GTPase-activating protein catalytic subunit (RAB3GAP1) 9.7
 LDTP19859  Small integral membrane protein 12 (SMIM12) 9.7
 LDTP19372  Tetratricopeptide repeat protein 38 (TTC38) 9.7
 LDTP08224  Protein LYRIC (MTDH) 9.6
 LDTP12468  Diablo IAP-binding mitochondrial protein (DIABLO) 9.5
 LDTP08094  Wings apart-like protein homolog (WAPL) 9.5
 LDTP15623  Neuferricin (CYB5D2) 9.4
 LDTP12412  Reticulon-4 (RTN4) 9.3
 LDTP00859  Synaptogyrin-2 (SYNGR2) 9.3
 LDTP18272  Transmembrane protein 209 (TMEM209) 9.3
 LDTP08154  Large ribosomal subunit protein uL10m (MRPL10) 9.1
 LDTP16192  Mitochondrial fission process protein 1 (MTFP1) 8.8
 LDTP15834  Integrator complex subunit 14 (INTS14) 8.7
 LDTP12192  Kinetochore protein Spc25 (SPC25) 8.5
 LDTP01652  Centrosomal protein 43 (CEP43) 8.3
 LDTP11197  Mini-chromosome maintenance complex-binding protein (MCMBP) 8.2
 LDTP05650  Twinfilin-1 (TWF1) 8.2

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587