Details of the Target

General Information of Target

Target ID	LDTP13311
Target Name	Poly(U)-binding-splicing factor PUF60 (PUF60)
Gene Name	PUF60
Gene ID	22827
Synonyms	FIR; ROBPI; SIAHBP1; Poly(U)-binding-splicing factor PUF60; 60 kDa poly(U)-binding-splicing factor; FUSE-binding protein-interacting repressor; FBP-interacting repressor; Ro-binding protein 1; RoBP1; Siah-binding protein 1; Siah-BP1
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MHPPETTTKMASVRFMVTPTKIDDIPGLSDTSPDLSSRSSSRVRFSSRESVPETSRSEPM SEMSGATTSLATVALDPPSDRTSHPQDVIEDLSQNSITGEHSQLLDDGHKKARNAYLNNS NYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKPT KTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSA IATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAA IFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYA GAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLWGFFCNSSQFFNATC DEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGEIIEKPSAKSSDVLGSLNHEYVLVD ITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGA CIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAK DNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNLA CALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQ GAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFA SQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGIS HLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNISFFP SNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDL ATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKD RNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQSN VRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRG GGSEVITIYS
Target Bioclass	Other
Family	RRM half pint family
Subcellular location	Nucleus
Function	DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation. In association with FUBP1 regulates MYC transcription at the P2 promoter through the core-TFIIH basal transcription factor. Acts as a transcriptional repressor through the core-TFIIH basal transcription factor. Represses FUBP1-induced transcriptional activation but not basal transcription. Decreases ERCC3 helicase activity. Does not repress TFIIH-mediated transcription in xeroderma pigmentosum complementation group B (XPB) cells. Is also involved in pre-mRNA splicing. Promotes splicing of an intron with weak 3'-splice site and pyrimidine tract in a cooperative manner with U2AF2. Involved in apoptosis induction when overexpressed in HeLa cells. Isoform 6 failed to repress MYC transcription and inhibited FIR-induced apoptosis in colorectal cancer. Isoform 6 may contribute to tumor progression by enabling increased MYC expression and greater resistance to apoptosis in tumors than in normal cells. Modulates alternative splicing of several mRNAs. Binds to relaxed DNA of active promoter regions. Binds to the pyrimidine tract and 3'-splice site regions of pre-mRNA; binding is enhanced in presence of U2AF2. Binds to Y5 RNA in association with RO60. Binds to poly(U) RNA.
Uniprot ID	Q9UHX1
Ensemble ID	ENST00000313352.11
HGNC ID	HGNC:17042

Probe(s) Labeling This Target

ABPP Probe

Click To Hide/Show 28 Probe Related to This Target

Probe name	Binding Site(Ratio)	Interaction ID	Ref
Jackson_1 Probe Info	10.62	LDD0122	[1]
C-Sul Probe Info	2.95	LDD0066	[2]
YN-1 Probe Info	100.00	LDD0444	[3]
STPyne Probe Info	K168(0.06); K201(8.27); K251(10.00); K265(1.85)	LDD0277	[4]
AZ-9 Probe Info	E482(0.88)	LDD2208	[5]
Probe 1 Probe Info	Y73(84.57); Y132(29.06)	LDD3495	[6]
BTD Probe Info	C129(2.96)	LDD1700	[7]
Johansson_61 Probe Info	_(20.00)	LDD1491	[8]
HHS-475 Probe Info	Y296(0.81); Y137(0.86); Y132(1.19)	LDD0264	[9]
DBIA Probe Info	C129(1.40)	LDD0531	[10]
5E-2FA Probe Info	N.A.	LDD2235	[11]
ATP probe Probe Info	K541(0.00); K458(0.00); K72(0.00); K454(0.00)	LDD0199	[12]
m-APA Probe Info	H234(0.00); H90(0.00); H526(0.00)	LDD2231	[11]
4-Iodoacetamidophenylacetylene Probe Info	C129(0.00); C487(0.00)	LDD0038	[13]
IA-alkyne Probe Info	N.A.	LDD0032	[14]
Lodoacetamide azide Probe Info	C129(0.00); C487(0.00)	LDD0037	[13]
ATP probe Probe Info	N.A.	LDD0035	[15]
TFBX Probe Info	C129(0.00); C255(0.00)	LDD0027	[16]
IPM Probe Info	C255(0.00); C129(0.00)	LDD0147	[16]
SF Probe Info	Y296(0.00); Y132(0.00); K267(0.00)	LDD0028	[17]
Ox-W18 Probe Info	N.A.	LDD2175	[18]
1c-yne Probe Info	K201(0.00); K243(0.00)	LDD0228	[19]
1d-yne Probe Info	N.A.	LDD0357	[19]
Acrolein Probe Info	C487(0.00); H449(0.00); H439(0.00); H234(0.00)	LDD0217	[20]
Crotonaldehyde Probe Info	C487(0.00); C255(0.00)	LDD0219	[20]
Methacrolein Probe Info	C487(0.00); C129(0.00)	LDD0218	[20]
NAIA_5 Probe Info	C487(0.00); C255(0.00)	LDD2223	[21]
HHS-465 Probe Info	Y269(0.00); K267(0.00); Y296(0.00); Y138(0.00)	LDD2240	[22]

PAL-AfBPP Probe

Click To Hide/Show 128 Probe Related to This Target

Probe name	Binding Site(Ratio)	Interaction ID	Ref
C001 Probe Info	13.93	LDD1711	[23]
C004 Probe Info	8.28	LDD1714	[23]
C007 Probe Info	17.15	LDD1716	[23]
C022 Probe Info	53.08	LDD1728	[23]
C026 Probe Info	10.93	LDD1732	[23]
C039 Probe Info	5.78	LDD1739	[23]
C040 Probe Info	22.63	LDD1740	[23]
C041 Probe Info	6.06	LDD1741	[23]
C049 Probe Info	5.13	LDD1747	[23]
C053 Probe Info	14.42	LDD1751	[23]
C063 Probe Info	24.42	LDD1760	[23]
C064 Probe Info	11.16	LDD1761	[23]
C070 Probe Info	12.91	LDD1766	[23]
C071 Probe Info	13.93	LDD1767	[23]
C072 Probe Info	8.46	LDD1768	[23]
C087 Probe Info	7.67	LDD1779	[23]
C092 Probe Info	42.52	LDD1783	[23]
C094 Probe Info	24.93	LDD1785	[23]
C095 Probe Info	10.48	LDD1786	[23]
C100 Probe Info	14.83	LDD1789	[23]
C106 Probe Info	84.45	LDD1793	[23]
C107 Probe Info	8.40	LDD1794	[23]
C108 Probe Info	11.55	LDD1795	[23]
C112 Probe Info	53.45	LDD1799	[23]
C130 Probe Info	6.54	LDD1812	[23]
C134 Probe Info	99.73	LDD1816	[23]
C139 Probe Info	26.17	LDD1821	[23]
C140 Probe Info	34.30	LDD1822	[23]
C141 Probe Info	9.58	LDD1823	[23]
C143 Probe Info	45.89	LDD1825	[23]
C147 Probe Info	13.36	LDD1829	[23]
C153 Probe Info	18.51	LDD1834	[23]
C159 Probe Info	9.51	LDD1839	[23]
C160 Probe Info	10.48	LDD1840	[23]
C161 Probe Info	34.78	LDD1841	[23]
C163 Probe Info	11.96	LDD1843	[23]
C169 Probe Info	49.87	LDD1849	[23]
C173 Probe Info	6.87	LDD1853	[23]
C177 Probe Info	10.41	LDD1856	[23]
C178 Probe Info	69.07	LDD1857	[23]
C183 Probe Info	5.21	LDD1861	[23]
C186 Probe Info	10.27	LDD1864	[23]
C187 Probe Info	17.15	LDD1865	[23]
C193 Probe Info	4.92	LDD1869	[23]
C194 Probe Info	15.35	LDD1870	[23]
C196 Probe Info	43.71	LDD1872	[23]
C201 Probe Info	99.73	LDD1877	[23]
C205 Probe Info	5.82	LDD1880	[23]
C206 Probe Info	70.52	LDD1881	[23]
C211 Probe Info	11.47	LDD1885	[23]
C213 Probe Info	29.04	LDD1887	[23]
C218 Probe Info	31.56	LDD1892	[23]
C219 Probe Info	8.17	LDD1893	[23]
C220 Probe Info	65.80	LDD1894	[23]
C225 Probe Info	29.45	LDD1898	[23]
C228 Probe Info	99.73	LDD1901	[23]
C229 Probe Info	11.47	LDD1902	[23]
C231 Probe Info	22.01	LDD1904	[23]
C232 Probe Info	42.22	LDD1905	[23]
C233 Probe Info	34.06	LDD1906	[23]
C238 Probe Info	12.82	LDD1911	[23]
C240 Probe Info	23.59	LDD1913	[23]
C243 Probe Info	11.00	LDD1916	[23]
C244 Probe Info	23.43	LDD1917	[23]
C246 Probe Info	41.36	LDD1919	[23]
C249 Probe Info	37.53	LDD1922	[23]
C264 Probe Info	25.28	LDD1935	[23]
C265 Probe Info	35.75	LDD1936	[23]
C277 Probe Info	11.88	LDD1947	[23]
C282 Probe Info	20.53	LDD1952	[23]
C284 Probe Info	39.95	LDD1954	[23]
C285 Probe Info	51.63	LDD1955	[23]
C286 Probe Info	63.12	LDD1956	[23]
C288 Probe Info	12.38	LDD1958	[23]
C289 Probe Info	48.84	LDD1959	[23]
C293 Probe Info	99.73	LDD1963	[23]
C296 Probe Info	37.79	LDD1966	[23]
C299 Probe Info	7.67	LDD1968	[23]
C300 Probe Info	18.38	LDD1969	[23]
C305 Probe Info	11.96	LDD1974	[23]
C307 Probe Info	6.23	LDD1975	[23]
C310 Probe Info	22.94	LDD1977	[23]
C314 Probe Info	18.90	LDD1981	[23]
C317 Probe Info	8.17	LDD1983	[23]
C326 Probe Info	8.46	LDD1990	[23]
C339 Probe Info	5.06	LDD2002	[23]
C340 Probe Info	11.96	LDD2003	[23]
C343 Probe Info	17.27	LDD2005	[23]
C348 Probe Info	10.34	LDD2009	[23]
C349 Probe Info	16.91	LDD2010	[23]
C350 Probe Info	99.73	LDD2011	[23]
C353 Probe Info	11.47	LDD2014	[23]
C354 Probe Info	7.57	LDD2015	[23]
C355 Probe Info	51.27	LDD2016	[23]
C356 Probe Info	55.33	LDD2017	[23]
C357 Probe Info	12.38	LDD2018	[23]
C362 Probe Info	34.78	LDD2023	[23]
C363 Probe Info	47.50	LDD2024	[23]
C364 Probe Info	38.32	LDD2025	[23]
C366 Probe Info	23.59	LDD2027	[23]
C367 Probe Info	70.52	LDD2028	[23]
C376 Probe Info	6.82	LDD2036	[23]
C378 Probe Info	6.28	LDD2037	[23]
C380 Probe Info	6.54	LDD2039	[23]
C388 Probe Info	64.89	LDD2047	[23]
C390 Probe Info	29.45	LDD2049	[23]
C399 Probe Info	9.00	LDD2058	[23]
C403 Probe Info	42.81	LDD2061	[23]
C405 Probe Info	5.13	LDD2063	[23]
C409 Probe Info	5.66	LDD2066	[23]
C413 Probe Info	49.87	LDD2069	[23]
C419 Probe Info	24.76	LDD2074	[23]
C420 Probe Info	14.12	LDD2075	[23]
C431 Probe Info	58.89	LDD2086	[23]
FFF probe11 Probe Info	20.00	LDD0471	[24]
FFF probe13 Probe Info	20.00	LDD0475	[24]
FFF probe14 Probe Info	14.75	LDD0477	[24]
FFF probe15 Probe Info	20.00	LDD0478	[24]
FFF probe2 Probe Info	16.63	LDD0463	[24]
FFF probe3 Probe Info	12.61	LDD0464	[24]
FFF probe4 Probe Info	14.59	LDD0466	[24]
JN0003 Probe Info	20.00	LDD0469	[24]
STS-2 Probe Info	1.00	LDD0139	[25]
VE-P Probe Info	N.A.	LDD0396	[26]
Dasatinib-CA-8PAP Probe Info	16.50	LDD0364	[27]
BD-F Probe Info	V483(0.00); E480(0.00)	LDD0024	[28]
LD-F Probe Info	V483(0.00); G481(0.00); L479(0.00); D478(0.00)	LDD0015	[28]
OEA-DA Probe Info	3.66	LDD0046	[29]

Competitor(s) Related to This Target

Competitor ID	Name	Cell line	Binding Site(Ratio)	Interaction ID	Ref
LDCM0524	2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide	MDA-MB-231	C129(1.07)	LDD2117	[7]
LDCM0558	2-Cyano-N-phenylacetamide	MDA-MB-231	C129(1.49)	LDD2152	[7]
LDCM0214	AC1	HCT 116	C129(1.40)	LDD0531	[10]
LDCM0215	AC10	HCT 116	C129(1.18)	LDD0532	[10]
LDCM0216	AC100	HCT 116	C129(0.75); C487(0.63)	LDD0533	[10]
LDCM0217	AC101	HCT 116	C129(0.68); C487(0.60)	LDD0534	[10]
LDCM0218	AC102	HCT 116	C129(0.84); C487(0.50)	LDD0535	[10]
LDCM0219	AC103	HCT 116	C129(0.65); C487(0.28)	LDD0536	[10]
LDCM0220	AC104	HCT 116	C129(0.95); C487(0.35)	LDD0537	[10]
LDCM0221	AC105	HCT 116	C129(0.64); C487(0.34)	LDD0538	[10]
LDCM0222	AC106	HCT 116	C129(0.62); C487(0.38)	LDD0539	[10]
LDCM0223	AC107	HCT 116	C129(0.70); C487(0.61)	LDD0540	[10]
LDCM0224	AC108	HCT 116	C129(0.73); C487(0.42)	LDD0541	[10]
LDCM0225	AC109	HCT 116	C129(0.91); C487(0.29)	LDD0542	[10]
LDCM0226	AC11	HCT 116	C129(1.23)	LDD0543	[10]
LDCM0227	AC110	HCT 116	C129(0.81); C487(0.36)	LDD0544	[10]
LDCM0228	AC111	HCT 116	C129(0.74); C487(0.39)	LDD0545	[10]
LDCM0229	AC112	HCT 116	C129(0.67); C487(0.43)	LDD0546	[10]
LDCM0230	AC113	HCT 116	C129(1.03)	LDD0547	[10]
LDCM0231	AC114	HCT 116	C129(1.01)	LDD0548	[10]
LDCM0232	AC115	HCT 116	C129(1.00)	LDD0549	[10]
LDCM0233	AC116	HCT 116	C129(1.12)	LDD0550	[10]
LDCM0234	AC117	HCT 116	C129(0.99)	LDD0551	[10]
LDCM0235	AC118	HCT 116	C129(0.95)	LDD0552	[10]
LDCM0236	AC119	HCT 116	C129(1.13)	LDD0553	[10]
LDCM0237	AC12	HCT 116	C129(1.13)	LDD0554	[10]
LDCM0238	AC120	HCT 116	C129(1.11)	LDD0555	[10]
LDCM0239	AC121	HCT 116	C129(0.92)	LDD0556	[10]
LDCM0240	AC122	HCT 116	C129(0.90)	LDD0557	[10]
LDCM0241	AC123	HCT 116	C129(0.72)	LDD0558	[10]
LDCM0242	AC124	HCT 116	C129(1.01)	LDD0559	[10]
LDCM0243	AC125	HCT 116	C129(1.01)	LDD0560	[10]
LDCM0244	AC126	HCT 116	C129(1.01)	LDD0561	[10]
LDCM0245	AC127	HCT 116	C129(0.97)	LDD0562	[10]
LDCM0246	AC128	HCT 116	C129(1.53)	LDD0563	[10]
LDCM0247	AC129	HCT 116	C129(1.72)	LDD0564	[10]
LDCM0249	AC130	HCT 116	C129(1.38)	LDD0566	[10]
LDCM0250	AC131	HCT 116	C129(1.30)	LDD0567	[10]
LDCM0251	AC132	HCT 116	C129(0.97)	LDD0568	[10]
LDCM0252	AC133	HCT 116	C129(1.45)	LDD0569	[10]
LDCM0253	AC134	HCT 116	C129(1.18)	LDD0570	[10]
LDCM0254	AC135	HCT 116	C129(1.17)	LDD0571	[10]
LDCM0255	AC136	HCT 116	C129(1.09)	LDD0572	[10]
LDCM0256	AC137	HCT 116	C129(0.81)	LDD0573	[10]
LDCM0257	AC138	HCT 116	C129(0.74)	LDD0574	[10]
LDCM0258	AC139	HCT 116	C129(1.00)	LDD0575	[10]
LDCM0259	AC14	HCT 116	C129(1.10)	LDD0576	[10]
LDCM0260	AC140	HCT 116	C129(0.99)	LDD0577	[10]
LDCM0261	AC141	HCT 116	C129(0.99)	LDD0578	[10]
LDCM0262	AC142	HCT 116	C129(1.30)	LDD0579	[10]
LDCM0263	AC143	HCT 116	C487(0.64); C129(0.76)	LDD0580	[10]
LDCM0264	AC144	HCT 116	C487(0.33); C129(1.35)	LDD0581	[10]
LDCM0265	AC145	HCT 116	C487(0.48); C129(1.51)	LDD0582	[10]
LDCM0266	AC146	HCT 116	C487(0.49); C129(1.06)	LDD0583	[10]
LDCM0267	AC147	HCT 116	C487(0.29); C129(1.27)	LDD0584	[10]
LDCM0268	AC148	HCT 116	C487(0.21); C129(1.17)	LDD0585	[10]
LDCM0269	AC149	HCT 116	C487(0.32); C129(1.23)	LDD0586	[10]
LDCM0270	AC15	HCT 116	C129(1.28)	LDD0587	[10]
LDCM0271	AC150	HCT 116	C487(0.51); C129(1.36)	LDD0588	[10]
LDCM0272	AC151	HCT 116	C487(0.54); C129(1.26)	LDD0589	[10]
LDCM0273	AC152	HCT 116	C487(0.27); C129(1.33)	LDD0590	[10]
LDCM0274	AC153	HCT 116	C487(0.23); C129(1.66)	LDD0591	[10]
LDCM0621	AC154	HCT 116	C129(1.20); C487(0.34)	LDD2158	[10]
LDCM0622	AC155	HCT 116	C129(1.17); C487(0.33)	LDD2159	[10]
LDCM0623	AC156	HCT 116	C129(1.41); C487(0.43)	LDD2160	[10]
LDCM0624	AC157	HCT 116	C129(1.02); C487(0.70)	LDD2161	[10]
LDCM0276	AC17	HCT 116	C487(0.62); C129(0.92)	LDD0593	[10]
LDCM0277	AC18	HCT 116	C487(0.31); C129(0.65)	LDD0594	[10]
LDCM0278	AC19	HCT 116	C487(0.65); C129(0.80)	LDD0595	[10]
LDCM0279	AC2	HCT 116	C129(1.24)	LDD0596	[10]
LDCM0280	AC20	HCT 116	C487(0.54); C129(0.90)	LDD0597	[10]
LDCM0281	AC21	HCT 116	C487(0.49); C129(0.81)	LDD0598	[10]
LDCM0282	AC22	HCT 116	C487(0.60); C129(0.91)	LDD0599	[10]
LDCM0283	AC23	HCT 116	C487(0.63); C129(0.69)	LDD0600	[10]
LDCM0284	AC24	HCT 116	C487(0.82); C129(1.05)	LDD0601	[10]
LDCM0285	AC25	HCT 116	C129(1.07)	LDD0602	[10]
LDCM0286	AC26	HCT 116	C129(0.95)	LDD0603	[10]
LDCM0287	AC27	HCT 116	C129(0.95)	LDD0604	[10]
LDCM0288	AC28	HCT 116	C129(0.88)	LDD0605	[10]
LDCM0289	AC29	HCT 116	C129(0.80)	LDD0606	[10]
LDCM0290	AC3	HCT 116	C129(1.41)	LDD0607	[10]
LDCM0291	AC30	HCT 116	C129(0.76)	LDD0608	[10]
LDCM0292	AC31	HCT 116	C129(0.95)	LDD0609	[10]
LDCM0293	AC32	HCT 116	C129(0.75)	LDD0610	[10]
LDCM0294	AC33	HCT 116	C129(1.02)	LDD0611	[10]
LDCM0295	AC34	HCT 116	C129(0.84)	LDD0612	[10]
LDCM0296	AC35	HCT 116	C129(1.10)	LDD0613	[10]
LDCM0297	AC36	HCT 116	C129(0.84)	LDD0614	[10]
LDCM0298	AC37	HCT 116	C129(0.95)	LDD0615	[10]
LDCM0299	AC38	HCT 116	C129(0.73)	LDD0616	[10]
LDCM0300	AC39	HCT 116	C129(1.08)	LDD0617	[10]
LDCM0301	AC4	HCT 116	C129(1.33)	LDD0618	[10]
LDCM0302	AC40	HCT 116	C129(1.08)	LDD0619	[10]
LDCM0303	AC41	HCT 116	C129(0.82)	LDD0620	[10]
LDCM0304	AC42	HCT 116	C129(0.80)	LDD0621	[10]
LDCM0305	AC43	HCT 116	C129(0.96)	LDD0622	[10]
LDCM0306	AC44	HCT 116	C129(0.83)	LDD0623	[10]
LDCM0307	AC45	HCT 116	C129(1.19)	LDD0624	[10]
LDCM0308	AC46	HCT 116	C129(0.87); C487(0.98)	LDD0625	[10]
LDCM0309	AC47	HCT 116	C487(0.81); C129(0.98)	LDD0626	[10]
LDCM0310	AC48	HCT 116	C129(0.98); C487(1.52)	LDD0627	[10]
LDCM0311	AC49	HCT 116	C487(0.61); C129(0.82)	LDD0628	[10]
LDCM0312	AC5	HCT 116	C129(1.62)	LDD0629	[10]
LDCM0313	AC50	HCT 116	C487(0.66); C129(0.86)	LDD0630	[10]
LDCM0314	AC51	HCT 116	C129(0.90); C487(1.44)	LDD0631	[10]
LDCM0315	AC52	HCT 116	C487(0.87); C129(0.93)	LDD0632	[10]
LDCM0316	AC53	HCT 116	C487(0.72); C129(1.00)	LDD0633	[10]
LDCM0317	AC54	HCT 116	C487(0.72); C129(1.20)	LDD0634	[10]
LDCM0318	AC55	HCT 116	C487(0.66); C129(0.89)	LDD0635	[10]
LDCM0319	AC56	HCT 116	C487(0.68); C129(0.93)	LDD0636	[10]
LDCM0320	AC57	HCT 116	C487(0.53); C129(1.20)	LDD0637	[10]
LDCM0321	AC58	HCT 116	C487(0.52); C129(0.82)	LDD0638	[10]
LDCM0322	AC59	HCT 116	C487(0.45); C129(0.91)	LDD0639	[10]
LDCM0323	AC6	HCT 116	C129(0.94)	LDD0640	[10]
LDCM0324	AC60	HCT 116	C487(0.60); C129(0.83)	LDD0641	[10]
LDCM0325	AC61	HCT 116	C487(0.81); C129(1.06)	LDD0642	[10]
LDCM0326	AC62	HCT 116	C487(0.42); C129(0.89)	LDD0643	[10]
LDCM0327	AC63	HCT 116	C487(0.53); C129(0.76)	LDD0644	[10]
LDCM0328	AC64	HCT 116	C487(0.43); C129(0.90)	LDD0645	[10]
LDCM0329	AC65	HCT 116	C487(0.53); C129(0.92)	LDD0646	[10]
LDCM0330	AC66	HCT 116	C487(0.58); C129(0.80)	LDD0647	[10]
LDCM0331	AC67	HCT 116	C487(0.34); C129(0.82)	LDD0648	[10]
LDCM0332	AC68	HCT 116	C487(0.76); C129(1.24)	LDD0649	[10]
LDCM0333	AC69	HCT 116	C487(0.70); C129(1.29)	LDD0650	[10]
LDCM0334	AC7	HCT 116	C129(1.00)	LDD0651	[10]
LDCM0335	AC70	HCT 116	C487(0.55); C129(1.31)	LDD0652	[10]
LDCM0336	AC71	HCT 116	C129(1.14); C487(1.16)	LDD0653	[10]
LDCM0337	AC72	HCT 116	C487(0.77); C129(1.48)	LDD0654	[10]
LDCM0338	AC73	HCT 116	C487(0.64); C129(1.25)	LDD0655	[10]
LDCM0339	AC74	HCT 116	C487(0.52); C129(1.05)	LDD0656	[10]
LDCM0340	AC75	HCT 116	C487(0.54); C129(1.42)	LDD0657	[10]
LDCM0341	AC76	HCT 116	C487(0.64); C129(1.17)	LDD0658	[10]
LDCM0342	AC77	HCT 116	C487(0.69); C129(1.22)	LDD0659	[10]
LDCM0343	AC78	HCT 116	C487(1.04); C129(1.23)	LDD0660	[10]
LDCM0344	AC79	HCT 116	C487(0.90); C129(1.36)	LDD0661	[10]
LDCM0345	AC8	HCT 116	C129(0.94)	LDD0662	[10]
LDCM0346	AC80	HCT 116	C487(0.58); C129(1.13)	LDD0663	[10]
LDCM0347	AC81	HCT 116	C487(0.89); C129(1.33)	LDD0664	[10]
LDCM0348	AC82	HCT 116	C487(0.60); C129(1.22)	LDD0665	[10]
LDCM0349	AC83	HCT 116	C129(0.67)	LDD0666	[10]
LDCM0350	AC84	HCT 116	C129(0.71)	LDD0667	[10]
LDCM0351	AC85	HCT 116	C129(0.77)	LDD0668	[10]
LDCM0352	AC86	HCT 116	C129(0.76)	LDD0669	[10]
LDCM0353	AC87	HCT 116	C129(0.87)	LDD0670	[10]
LDCM0354	AC88	HCT 116	C129(0.83)	LDD0671	[10]
LDCM0355	AC89	HCT 116	C129(0.77)	LDD0672	[10]
LDCM0357	AC90	HCT 116	C129(1.00)	LDD0674	[10]
LDCM0358	AC91	HCT 116	C129(0.81)	LDD0675	[10]
LDCM0359	AC92	HCT 116	C129(0.70)	LDD0676	[10]
LDCM0360	AC93	HCT 116	C129(0.85)	LDD0677	[10]
LDCM0361	AC94	HCT 116	C129(1.01)	LDD0678	[10]
LDCM0362	AC95	HCT 116	C129(0.72)	LDD0679	[10]
LDCM0363	AC96	HCT 116	C129(0.92)	LDD0680	[10]
LDCM0364	AC97	HCT 116	C129(0.62)	LDD0681	[10]
LDCM0365	AC98	HCT 116	C487(0.18); C129(0.67)	LDD0682	[10]
LDCM0366	AC99	HCT 116	C487(0.58); C129(0.63)	LDD0683	[10]
LDCM0545	Acetamide	MDA-MB-231	C129(0.89)	LDD2138	[7]
LDCM0248	AKOS034007472	HCT 116	C129(1.09)	LDD0565	[10]
LDCM0356	AKOS034007680	HCT 116	C129(1.06)	LDD0673	[10]
LDCM0275	AKOS034007705	HCT 116	C129(1.02)	LDD0592	[10]
LDCM0108	Chloroacetamide	HeLa	C487(0.00); C129(0.00); H449(0.00)	LDD0222	[20]
LDCM0367	CL1	HCT 116	C129(0.82); C487(1.23)	LDD0684	[10]
LDCM0368	CL10	HCT 116	C487(0.55); C129(1.54)	LDD0685	[10]
LDCM0369	CL100	HCT 116	C129(1.25)	LDD0686	[10]
LDCM0370	CL101	HCT 116	C129(1.04)	LDD0687	[10]
LDCM0371	CL102	HCT 116	C129(1.08)	LDD0688	[10]
LDCM0372	CL103	HCT 116	C129(1.16)	LDD0689	[10]
LDCM0373	CL104	HCT 116	C129(0.98)	LDD0690	[10]
LDCM0374	CL105	HCT 116	C487(0.48); C129(0.74)	LDD0691	[10]
LDCM0375	CL106	HCT 116	C487(0.27); C129(0.69)	LDD0692	[10]
LDCM0376	CL107	HCT 116	C487(0.26); C129(0.83)	LDD0693	[10]
LDCM0377	CL108	HCT 116	C487(0.25); C129(0.83)	LDD0694	[10]
LDCM0378	CL109	HCT 116	C487(0.57); C129(0.92)	LDD0695	[10]
LDCM0379	CL11	HCT 116	C487(0.49); C129(1.48)	LDD0696	[10]
LDCM0380	CL110	HCT 116	C487(0.38); C129(0.84)	LDD0697	[10]
LDCM0381	CL111	HCT 116	C487(0.48); C129(0.77)	LDD0698	[10]
LDCM0382	CL112	HCT 116	C129(0.99)	LDD0699	[10]
LDCM0383	CL113	HCT 116	C129(0.73)	LDD0700	[10]
LDCM0384	CL114	HCT 116	C129(0.77)	LDD0701	[10]
LDCM0385	CL115	HCT 116	C129(0.85)	LDD0702	[10]
LDCM0386	CL116	HCT 116	C129(0.95)	LDD0703	[10]
LDCM0387	CL117	HCT 116	C129(0.85)	LDD0704	[10]
LDCM0388	CL118	HCT 116	C129(0.88)	LDD0705	[10]
LDCM0389	CL119	HCT 116	C129(0.93)	LDD0706	[10]
LDCM0390	CL12	HCT 116	C487(0.53); C129(1.80)	LDD0707	[10]
LDCM0391	CL120	HCT 116	C129(0.92)	LDD0708	[10]
LDCM0392	CL121	HCT 116	C487(0.78); C129(0.95)	LDD0709	[10]
LDCM0393	CL122	HCT 116	C487(0.95); C129(0.99)	LDD0710	[10]
LDCM0394	CL123	HCT 116	C487(0.72); C129(1.11)	LDD0711	[10]
LDCM0395	CL124	HCT 116	C487(0.61); C129(0.95)	LDD0712	[10]
LDCM0396	CL125	HCT 116	C129(1.11); C487(1.32)	LDD0713	[10]
LDCM0397	CL126	HCT 116	C487(0.75); C129(0.84)	LDD0714	[10]
LDCM0398	CL127	HCT 116	C129(0.83); C487(0.92)	LDD0715	[10]
LDCM0399	CL128	HCT 116	C487(0.51); C129(1.34)	LDD0716	[10]
LDCM0400	CL13	HCT 116	C487(0.70); C129(1.08)	LDD0717	[10]
LDCM0401	CL14	HCT 116	C129(1.04); C487(1.06)	LDD0718	[10]
LDCM0402	CL15	HCT 116	C487(0.62); C129(0.97)	LDD0719	[10]
LDCM0403	CL16	HCT 116	C129(0.71)	LDD0720	[10]
LDCM0404	CL17	HCT 116	C129(1.16)	LDD0721	[10]
LDCM0405	CL18	HCT 116	C129(0.94)	LDD0722	[10]
LDCM0406	CL19	HCT 116	C129(1.07)	LDD0723	[10]
LDCM0407	CL2	HCT 116	C487(0.80); C129(0.89)	LDD0724	[10]
LDCM0408	CL20	HCT 116	C129(0.91)	LDD0725	[10]
LDCM0409	CL21	HCT 116	C129(1.02)	LDD0726	[10]
LDCM0410	CL22	HCT 116	C129(0.87)	LDD0727	[10]
LDCM0411	CL23	HCT 116	C129(0.81)	LDD0728	[10]
LDCM0412	CL24	HCT 116	C129(0.86)	LDD0729	[10]
LDCM0413	CL25	HCT 116	C129(0.80)	LDD0730	[10]
LDCM0414	CL26	HCT 116	C129(0.60)	LDD0731	[10]
LDCM0415	CL27	HCT 116	C129(1.04)	LDD0732	[10]
LDCM0416	CL28	HCT 116	C129(0.79)	LDD0733	[10]
LDCM0417	CL29	HCT 116	C129(0.90)	LDD0734	[10]
LDCM0418	CL3	HCT 116	C129(1.04); C487(0.80)	LDD0735	[10]
LDCM0419	CL30	HCT 116	C129(0.77)	LDD0736	[10]
LDCM0420	CL31	HCT 116	C129(0.91); C487(0.50)	LDD0737	[10]
LDCM0421	CL32	HCT 116	C129(0.76); C487(0.49)	LDD0738	[10]
LDCM0422	CL33	HCT 116	C129(0.73); C487(0.54)	LDD0739	[10]
LDCM0423	CL34	HCT 116	C129(0.72); C487(0.33)	LDD0740	[10]
LDCM0424	CL35	HCT 116	C129(0.84); C487(0.31)	LDD0741	[10]
LDCM0425	CL36	HCT 116	C129(0.75); C487(0.31)	LDD0742	[10]
LDCM0426	CL37	HCT 116	C129(0.86); C487(0.39)	LDD0743	[10]
LDCM0428	CL39	HCT 116	C129(0.97); C487(0.34)	LDD0745	[10]
LDCM0429	CL4	HCT 116	C129(0.81); C487(0.94)	LDD0746	[10]
LDCM0430	CL40	HCT 116	C129(0.76); C487(0.30)	LDD0747	[10]
LDCM0431	CL41	HCT 116	C129(0.86); C487(0.37)	LDD0748	[10]
LDCM0432	CL42	HCT 116	C129(0.65); C487(0.31)	LDD0749	[10]
LDCM0433	CL43	HCT 116	C129(0.86); C487(0.33)	LDD0750	[10]
LDCM0434	CL44	HCT 116	C129(0.79); C487(0.44)	LDD0751	[10]
LDCM0435	CL45	HCT 116	C129(0.88); C487(0.39)	LDD0752	[10]
LDCM0436	CL46	HCT 116	C129(1.09)	LDD0753	[10]
LDCM0437	CL47	HCT 116	C129(1.11)	LDD0754	[10]
LDCM0438	CL48	HCT 116	C129(1.26)	LDD0755	[10]
LDCM0439	CL49	HCT 116	C129(1.19)	LDD0756	[10]
LDCM0440	CL5	HCT 116	C129(1.09); C487(0.83)	LDD0757	[10]
LDCM0441	CL50	HCT 116	C129(1.15)	LDD0758	[10]
LDCM0442	CL51	HCT 116	C129(1.15)	LDD0759	[10]
LDCM0443	CL52	HCT 116	C129(1.12)	LDD0760	[10]
LDCM0444	CL53	HCT 116	C129(0.96)	LDD0761	[10]
LDCM0445	CL54	HCT 116	C129(1.10)	LDD0762	[10]
LDCM0446	CL55	HCT 116	C129(1.14)	LDD0763	[10]
LDCM0447	CL56	HCT 116	C129(0.96)	LDD0764	[10]
LDCM0448	CL57	HCT 116	C129(0.94)	LDD0765	[10]
LDCM0449	CL58	HCT 116	C129(1.11)	LDD0766	[10]
LDCM0450	CL59	HCT 116	C129(1.04)	LDD0767	[10]
LDCM0451	CL6	HCT 116	C129(1.02); C487(0.84)	LDD0768	[10]
LDCM0452	CL60	HCT 116	C129(1.14)	LDD0769	[10]
LDCM0453	CL61	HCT 116	C129(0.95); C487(0.59)	LDD0770	[10]
LDCM0454	CL62	HCT 116	C129(0.86); C487(0.72)	LDD0771	[10]
LDCM0455	CL63	HCT 116	C129(0.87); C487(0.73)	LDD0772	[10]
LDCM0456	CL64	HCT 116	C129(0.93); C487(0.44)	LDD0773	[10]
LDCM0457	CL65	HCT 116	C129(1.09); C487(0.75)	LDD0774	[10]
LDCM0458	CL66	HCT 116	C129(0.96); C487(0.38)	LDD0775	[10]
LDCM0459	CL67	HCT 116	C129(1.00); C487(0.41)	LDD0776	[10]
LDCM0460	CL68	HCT 116	C129(0.89); C487(0.57)	LDD0777	[10]
LDCM0461	CL69	HCT 116	C129(0.70); C487(0.95)	LDD0778	[10]
LDCM0462	CL7	HCT 116	C129(1.60); C487(0.61)	LDD0779	[10]
LDCM0463	CL70	HCT 116	C129(0.97); C487(0.66)	LDD0780	[10]
LDCM0464	CL71	HCT 116	C129(0.84); C487(0.52)	LDD0781	[10]
LDCM0465	CL72	HCT 116	C129(0.73); C487(0.66)	LDD0782	[10]
LDCM0466	CL73	HCT 116	C129(0.91); C487(0.53)	LDD0783	[10]
LDCM0467	CL74	HCT 116	C129(0.99); C487(0.47)	LDD0784	[10]
LDCM0469	CL76	HCT 116	C129(0.96)	LDD0786	[10]
LDCM0470	CL77	HCT 116	C129(0.67)	LDD0787	[10]
LDCM0471	CL78	HCT 116	C129(0.96)	LDD0788	[10]
LDCM0472	CL79	HCT 116	C129(0.86)	LDD0789	[10]
LDCM0473	CL8	HCT 116	C129(0.76); C487(0.56)	LDD0790	[10]
LDCM0474	CL80	HCT 116	C129(0.95)	LDD0791	[10]
LDCM0475	CL81	HCT 116	C129(0.91)	LDD0792	[10]
LDCM0476	CL82	HCT 116	C129(0.93)	LDD0793	[10]
LDCM0477	CL83	HCT 116	C129(0.86)	LDD0794	[10]
LDCM0478	CL84	HCT 116	C129(0.93)	LDD0795	[10]
LDCM0479	CL85	HCT 116	C129(0.74)	LDD0796	[10]
LDCM0480	CL86	HCT 116	C129(0.83)	LDD0797	[10]
LDCM0481	CL87	HCT 116	C129(0.83)	LDD0798	[10]
LDCM0482	CL88	HCT 116	C129(0.90)	LDD0799	[10]
LDCM0483	CL89	HCT 116	C129(0.78)	LDD0800	[10]
LDCM0484	CL9	HCT 116	C129(0.91); C487(0.60)	LDD0801	[10]
LDCM0485	CL90	HCT 116	C129(0.73)	LDD0802	[10]
LDCM0486	CL91	HCT 116	C129(1.00)	LDD0803	[10]
LDCM0487	CL92	HCT 116	C129(1.08)	LDD0804	[10]
LDCM0488	CL93	HCT 116	C129(1.30)	LDD0805	[10]
LDCM0489	CL94	HCT 116	C129(1.19)	LDD0806	[10]
LDCM0490	CL95	HCT 116	C129(1.25)	LDD0807	[10]
LDCM0491	CL96	HCT 116	C129(1.35)	LDD0808	[10]
LDCM0492	CL97	HCT 116	C129(1.22)	LDD0809	[10]
LDCM0493	CL98	HCT 116	C129(1.04)	LDD0810	[10]
LDCM0494	CL99	HCT 116	C129(1.13)	LDD0811	[10]
LDCM0097	Dasatinib	K562	16.50	LDD0364	[27]
LDCM0495	E2913	HEK-293T	C129(1.05)	LDD1698	[30]
LDCM0625	F8	Ramos	C129(0.75); C487(0.48)	LDD2187	[31]
LDCM0572	Fragment10	Ramos	C129(0.73); C487(0.42)	LDD2189	[31]
LDCM0573	Fragment11	Ramos	C129(0.01); C487(1.05)	LDD2190	[31]
LDCM0574	Fragment12	Ramos	C129(0.85); C487(0.51)	LDD2191	[31]
LDCM0575	Fragment13	Ramos	C129(1.01); C487(0.54)	LDD2192	[31]
LDCM0576	Fragment14	Ramos	C129(0.90)	LDD2193	[31]
LDCM0579	Fragment20	Ramos	C129(0.62); C487(0.39)	LDD2194	[31]
LDCM0580	Fragment21	Ramos	C129(0.89); C487(0.66)	LDD2195	[31]
LDCM0582	Fragment23	Ramos	C129(1.30); C487(0.94)	LDD2196	[31]
LDCM0578	Fragment27	Ramos	C129(0.97); C487(0.69)	LDD2197	[31]
LDCM0586	Fragment28	Ramos	C129(0.68); C487(0.61)	LDD2198	[31]
LDCM0588	Fragment30	Ramos	C129(1.26); C487(0.76)	LDD2199	[31]
LDCM0589	Fragment31	Ramos	C129(1.49); C487(0.58)	LDD2200	[31]
LDCM0590	Fragment32	Ramos	C129(0.68); C487(0.47)	LDD2201	[31]
LDCM0468	Fragment33	HCT 116	C129(0.91); C487(0.56)	LDD0785	[10]
LDCM0596	Fragment38	Ramos	C129(1.04); C487(0.60)	LDD2203	[31]
LDCM0566	Fragment4	Ramos	C129(0.70)	LDD2184	[31]
LDCM0427	Fragment51	HCT 116	C129(0.69); C487(0.31)	LDD0744	[10]
LDCM0610	Fragment52	Ramos	C129(1.17); C487(0.49)	LDD2204	[31]
LDCM0614	Fragment56	Ramos	C129(1.31); C487(0.67)	LDD2205	[31]
LDCM0617	Fragment63-S	Jurkat	_(20.00)	LDD1491	[8]
LDCM0569	Fragment7	Ramos	C129(0.54)	LDD2186	[31]
LDCM0571	Fragment9	Ramos	C129(0.65); C487(0.53)	LDD2188	[31]
LDCM0116	HHS-0101	DM93	Y296(0.81); Y137(0.86); Y132(1.19)	LDD0264	[9]
LDCM0117	HHS-0201	DM93	Y296(0.69); Y137(1.43); Y132(4.46)	LDD0265	[9]
LDCM0118	HHS-0301	DM93	Y132(0.83); Y137(0.83); Y296(0.85)	LDD0266	[9]
LDCM0119	HHS-0401	DM93	Y296(0.91); Y137(1.69); Y132(2.38)	LDD0267	[9]
LDCM0120	HHS-0701	DM93	Y296(0.77); Y137(1.04); Y132(3.21)	LDD0268	[9]
LDCM0107	IAA	HeLa	C487(0.00); C129(0.00); H234(0.00)	LDD0221	[20]
LDCM0022	KB02	HEK-293T	C129(1.02)	LDD1492	[30]
LDCM0023	KB03	HEK-293T	C129(1.10)	LDD1497	[30]
LDCM0024	KB05	HMCB	C86(3.06)	LDD3312	[32]
LDCM0109	NEM	HeLa	C487(0.00); H234(0.00); C129(0.00); H449(0.00)	LDD0223	[20]
LDCM0500	Nucleophilic fragment 13a	MDA-MB-231	C129(1.32)	LDD2093	[7]
LDCM0503	Nucleophilic fragment 14b	MDA-MB-231	C129(0.15)	LDD2096	[7]
LDCM0504	Nucleophilic fragment 15a	MDA-MB-231	C129(0.86)	LDD2097	[7]
LDCM0506	Nucleophilic fragment 16a	MDA-MB-231	C129(1.63)	LDD2099	[7]
LDCM0516	Nucleophilic fragment 21a	MDA-MB-231	C129(0.62)	LDD2109	[7]
LDCM0518	Nucleophilic fragment 22a	MDA-MB-231	C129(1.59)	LDD2111	[7]
LDCM0526	Nucleophilic fragment 26a	MDA-MB-231	C129(1.91)	LDD2119	[7]
LDCM0527	Nucleophilic fragment 26b	MDA-MB-231	C129(0.88)	LDD2120	[7]
LDCM0530	Nucleophilic fragment 28a	MDA-MB-231	C129(1.01)	LDD2123	[7]
LDCM0531	Nucleophilic fragment 28b	MDA-MB-231	C129(0.56)	LDD2124	[7]
LDCM0532	Nucleophilic fragment 29a	MDA-MB-231	C129(0.95)	LDD2125	[7]
LDCM0533	Nucleophilic fragment 29b	MDA-MB-231	C129(0.44)	LDD2126	[7]
LDCM0534	Nucleophilic fragment 30a	MDA-MB-231	C129(1.12)	LDD2127	[7]
LDCM0535	Nucleophilic fragment 30b	MDA-MB-231	C129(0.91)	LDD2128	[7]
LDCM0536	Nucleophilic fragment 31	MDA-MB-231	C129(1.88)	LDD2129	[7]
LDCM0541	Nucleophilic fragment 36	MDA-MB-231	C129(0.39)	LDD2134	[7]
LDCM0542	Nucleophilic fragment 37	MDA-MB-231	C129(2.36)	LDD2135	[7]
LDCM0543	Nucleophilic fragment 38	MDA-MB-231	C129(0.63)	LDD2136	[7]
LDCM0544	Nucleophilic fragment 39	MDA-MB-231	C129(1.08)	LDD2137	[7]
LDCM0211	Nucleophilic fragment 3b	MDA-MB-231	C129(2.96)	LDD1700	[7]
LDCM0546	Nucleophilic fragment 40	MDA-MB-231	C129(0.97)	LDD2140	[7]
LDCM0549	Nucleophilic fragment 43	MDA-MB-231	C129(0.55)	LDD2143	[7]
LDCM0550	Nucleophilic fragment 5a	MDA-MB-231	C129(2.04)	LDD2144	[7]
LDCM0552	Nucleophilic fragment 6a	MDA-MB-231	C129(1.11)	LDD2146	[7]
LDCM0553	Nucleophilic fragment 6b	MDA-MB-231	C129(0.96)	LDD2147	[7]
LDCM0557	Nucleophilic fragment 8b	MDA-MB-231	C129(0.52)	LDD2151	[7]
LDCM0131	RA190	MM1.R	C129(1.35); C487(1.27)	LDD0304	[33]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme

Click To Hide/Show 3 Protein(s) Interacting with This Target

Protein name	Family	Uniprot ID
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)	Glyceraldehyde-3-phosphate dehydrogenase family	P04406
E3 ubiquitin-protein ligase SIAH1 (SIAH1)	SINA (Seven in absentia) family	Q8IUQ4
ADP-ribosylation factor-like protein 8A (ARL8A)	Arf family	Q96BM9

Transporter and channel

Click To Hide/Show 3 Protein(s) Interacting with This Target

Protein name	Family	Uniprot ID
Voltage-dependent P/Q-type calcium channel subunit alpha-1A (CACNA1A)	Calcium channel alpha-1 subunit (TC 1.A.1.11) family	O00555
Huntingtin (HTT)	Huntingtin family	P42858
Syntenin-1 (SDCBP)	.	O00560

Transcription factor

Click To Hide/Show 3 Protein(s) Interacting with This Target

Protein name	Family	Uniprot ID
SAP30-binding protein (SAP30BP)	HCNGP family	Q9UHR5
Transcriptional regulator QRICH1 (QRICH1)	.	Q2TAL8
Upstream-binding factor 1-like protein 1 (UBTFL1)	.	P0CB47

Other

Click To Hide/Show 16 Protein(s) Interacting with This Target

Protein name	Family	Uniprot ID
BLOC-1-related complex subunit 5 (BORCS5)	BORCS5 family	Q969J3
Cyclin-C (CCNC)	Cyclin family	P24863
DNA damage-inducible transcript 4-like protein (DDIT4L)	DDIT4 family	Q96D03
Ferritin heavy polypeptide-like 17 (FTHL17)	Ferritin family	Q9BXU8
Zymogen granule membrane protein 16 (ZG16)	Jacalin lectin family	O60844
KH homology domain-containing protein 4 (KHDC4)	KHDC4 family	Q7Z7F0
Mediator of RNA polymerase II transcription subunit 28 (MED28)	Mediator complex subunit 28 family	Q9H204
UV excision repair protein RAD23 homolog B (RAD23B)	RAD23 family	P54727
Poly(U)-binding-splicing factor PUF60 (PUF60)	RRM half pint family	Q9UHX1
Serine/arginine-rich splicing factor 11 (SRSF11)	Splicing factor SR family	Q05519
Splicing factor U2AF 65 kDa subunit (U2AF2)	Splicing factor SR family	P26368
Transcription initiation factor TFIID subunit 2 (TAF2)	TAF2 family	Q6P1X5
IQ domain-containing protein N (IQCN)	.	Q9H0B3
Poly(rC)-binding protein 1 (PCBP1)	.	Q15365
Protein phosphatase 1 regulatory subunit 16A (PPP1R16A)	.	Q96I34
Regulator of nonsense transcripts 2 (UPF2)	.	Q9HAU5

References

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2	Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
3	Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4	A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10. Mass spectrometry data entry: PXD028270
5	2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
6	An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
7	Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29. Mass spectrometry data entry: PXD039908 , PXD029761
8	Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
9	Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
10	Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11	Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print. Mass spectrometry data entry: PXD042377
12	Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
13	Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23. Mass spectrometry data entry: PXD028853
14	SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18. Mass spectrometry data entry*: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
15	Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22. Mass spectrometry data entry: PXD006095 , PXD006096
16	Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24. Mass spectrometry data entry: PXD029255
17	Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022. Mass spectrometry data entry: PXD039931
18	Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6. Mass spectrometry data entry: PXD001377 , PXD005252
19	Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
20	ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
21	N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w. Mass spectrometry data entry: PXD041264
22	Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6. Mass spectrometry data entry: PXD038010
23	Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26. Mass spectrometry data entry: PXD041587
24	Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
25	Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
26	Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
27	Streamlined Target Deconvolution Approach Utilizing a Single Photoreactive Chloroalkane Capture Tag. ACS Chem Biol. 2021 Feb 19;16(2):404-413. doi: 10.1021/acschembio.0c00987. Epub 2021 Feb 5.
28	Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b. Mass spectrometry data entry: PXD025652
29	Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20. Mass spectrometry data entry: PXD007570
30	Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19. Mass spectrometry data entry: PXD044402
31	Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7. Mass spectrometry data entry: PXD027578
32	DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22. Mass spectrometry data entry: PXD047840
33	Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.

Details of the Target

Citation

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Correspondence

Prof. Feng Zhu

Prof. Feng Ni