Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C218  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 177 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP00697  Cytochrome b5 type B (CYB5B) 99.7
 LDTP07831  Transmembrane protein with metallophosphoesterase domain (TMPPE) 74.0
 LDTP01769  Dihydrofolate reductase (DHFR) 54.9
 LDTP14276  NADH dehydrogenase 1 beta subcomplex subunit 9 (NDUFB9) 47.8
 LDTP06750  Prolyl 3-hydroxylase 1 (P3H1) 46.2
 LDTP03540  Heme oxygenase 2 (HMOX2) 45.6
 LDTP05862  NAD(P) transhydrogenase, mitochondrial (NNT) 44.9
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 43.7
 LDTP06477  Methylsterol monooxygenase 1 (MSMO1) 41.6
 LDTP05408  Antigen peptide transporter 1 (TAP1) 38.9
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 38.3
 LDTP12628  Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) 37.8
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 37.5
 LDTP01571  Phenylalanine--tRNA ligase, mitochondrial (FARS2) 36.5
 LDTP04437  Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) 36.0
 LDTP01462  Endonuclease domain-containing 1 protein (ENDOD1) 36.0
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 36.0
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 34.3
 LDTP01687  Apoptosis-inducing factor 1, mitochondrial (AIFM1) 33.1
 LDTP11127  ADP-dependent glucokinase (ADPGK) 31.8
 LDTP00486  Cytochrome b-c1 complex subunit 8 (UQCRQ) 31.3
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 30.3
 LDTP05066  Signal peptidase complex catalytic subunit SEC11A (SEC11A) 30.1
 LDTP01773  Cytochrome c oxidase subunit 2 (MT-CO2) 29.2
 LDTP06787  Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) 28.2
 LDTP16007  Lipid droplet-associated hydrolase (LDAH) 27.9
 LDTP01982  NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) 27.9
 LDTP15328  Dolichyldiphosphatase 1 (DOLPP1) 27.1
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 26.9
 LDTP04581  Holocytochrome c-type synthase (HCCS) 26.7
 LDTP08790  Mitochondrial cardiolipin hydrolase (PLD6) 26.0
 LDTP14218  Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) 26.0
 LDTP08728  Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) 24.9
 LDTP11178  Chitobiosyldiphosphodolichol beta-mannosyltransferase (ALG1) 24.4
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 23.9
 LDTP11225  Deoxyhypusine hydroxylase (DOHH) 23.6
 LDTP08385  NADH dehydrogenase 1 alpha subcomplex subunit 11 (NDUFA11) 23.6
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 23.4
 LDTP03139  Succinate dehydrogenase iron-sulfur subunit, mitochondrial (SDHB) 23.1
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 22.9
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 22.9
 LDTP06617  Ceramide glucosyltransferase (UGCG) 22.8
 LDTP06150  DNA replication licensing factor MCM6 (MCM6) 22.6
 LDTP06384  Ribosomal protein S6 kinase alpha-1 (RPS6KA1) 22.6
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 22.3
 LDTP05396  Histone-lysine N-methyltransferase 2A (KMT2A) 22.3
 LDTP12959  NADH dehydrogenase 1 alpha subcomplex subunit 13 (NDUFA13) 22.3
 LDTP03671  Multidrug resistance-associated protein 1 (ABCC1) 22.0
 LDTP09556  E3 ubiquitin-protein ligase RNF139 (RNF139) 21.9
 LDTP01219  NADH dehydrogenase 1 beta subcomplex subunit 1 (NDUFB1) 21.9
 LDTP01613  Sphingosine-1-phosphate lyase 1 (SGPL1) 21.7
 LDTP09874  Endoplasmic reticulum protein SC65 (P3H4) 21.6
 LDTP09251  Atlastin-2 (ATL2) 21.4
 LDTP17410  Cytochrome P450 20A1 (CYP20A1) 21.4
 LDTP04286  DNA replication licensing factor MCM2 (MCM2) 21.1
 LDTP06270  Signal peptidase complex subunit 2 (SPCS2) 21.1
 LDTP04120  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (STT3A) 21.0
 LDTP07990  Heparan sulfate 2-O-sulfotransferase 1 (HS2ST1) 20.7
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 20.5
 LDTP02359  Heme oxygenase 1 (HMOX1) 20.0
 LDTP07259  N-alpha-acetyltransferase 35, NatC auxiliary subunit (NAA35) 20.0
 LDTP09096  Carbohydrate sulfotransferase 14 (CHST14) 19.8
 LDTP12868  Endoplasmic reticulum aminopeptidase 1 (ERAP1) 19.8
 LDTP01649  Phosphatidate cytidylyltransferase 2 (CDS2) 19.7
 LDTP11867  UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase (DPAGT1) 19.7
 LDTP12586  Phenylalanine--tRNA ligase beta subunit (FARSB) 19.6
 LDTP10020  Ras-related protein Rab-24 (RAB24) 19.0
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) 18.9
 LDTP06142  Squalene monooxygenase (SQLE) 18.9
 LDTP12873  CDGSH iron-sulfur domain-containing protein 1 (CISD1) 18.8
 LDTP02860  Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) 18.6
 LDTP12867  Very-long-chain enoyl-CoA reductase (TECR) 18.4
 LDTP10612  Lysophospholipid acyltransferase 7 (MBOAT7) 18.3
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 18.1
 LDTP03145  Catechol O-methyltransferase (COMT) 17.6
 LDTP12954  Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 (HACD3) 17.6
 LDTP10329  Ceramide synthase 2 (CERS2) 17.5
 LDTP18087  Dephospho-CoA kinase domain-containing protein (DCAKD) 17.3
 LDTP06546  Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform (PPP2R5E) 17.1
 LDTP01743  NADH dehydrogenase 1 beta subcomplex subunit 10 (NDUFB10) 17.0
 LDTP09061  Retinol dehydrogenase 13 (RDH13) 17.0
 LDTP00597  Serine palmitoyltransferase 1 (SPTLC1) 16.9
 LDTP04438  Succinate-semialdehyde dehydrogenase, mitochondrial (ALDH5A1) 16.9
 LDTP01983  NADH-ubiquinone oxidoreductase chain 2 (MT-ND2) 16.8
 LDTP05480  Amidophosphoribosyltransferase (PPAT) 16.6
 LDTP08859  Polypeptide N-acetylgalactosaminyltransferase 4 (GALNT4) 16.6
 LDTP11874  Thioredoxin-related transmembrane protein 1 (TMX1) 16.6
 LDTP06901  Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) 16.4
 LDTP04471  Ribosomal protein S6 kinase alpha-3 (RPS6KA3) 16.3
 LDTP12763  Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase (BPNT2) 16.2
 LDTP08455  Palmitoyltransferase ZDHHC13 (ZDHHC13) 16.2
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 16.1
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 16.0
 LDTP07003  Presequence protease, mitochondrial (PITRM1) 16.0
 LDTP01284  Mitochondrial tRNA-specific 2-thiouridylase 1 (TRMU) 15.6
 LDTP09666  Reticulon-4-interacting protein 1, mitochondrial (RTN4IP1) 15.5
 LDTP02067  Sodium/potassium-transporting ATPase subunit alpha-1 (ATP1A1) 15.2
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 14.9
 LDTP05632  Mitochondrial-processing peptidase subunit alpha (PMPCA) 14.9
 LDTP10471  Protein disulfide-isomerase TMX3 (TMX3) 14.9
 LDTP00400  Torsin-1B (TOR1B) 14.9
 LDTP12415  Adenosine 5'-monophosphoramidase HINT3 (HINT3) 14.6
 LDTP06200  Delta(14)-sterol reductase LBR (LBR) 14.6
 LDTP12105  L-2-hydroxyglutarate dehydrogenase, mitochondrial (L2HGDH) 14.6
 LDTP02679  Prolyl 4-hydroxylase subunit alpha-1 (P4HA1) 14.5
 LDTP12639  1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon (AGPAT5) 14.4
 LDTP06721  GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase (ALG11) 14.4
 LDTP00589  Peroxisomal acyl-coenzyme A oxidase 3 (ACOX3) 14.4
 LDTP03608  RAC-beta serine/threonine-protein kinase (AKT2) 14.4
 LDTP00344  Stearoyl-CoA desaturase (SCD) 14.4
 LDTP04531  Hexokinase-2 (HK2) 14.3
 LDTP15962  Protein-L-histidine N-pros-methyltransferase (METTL9) 14.2
 LDTP12681  ATPase family AAA domain-containing protein 3A (ATAD3A) 14.1
 LDTP05920  Calcium/calmodulin-dependent protein kinase type II subunit gamma (CAMK2G) 14.1
 LDTP00907  Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D) 14.1
 LDTP02123  Protein kinase C beta type (PRKCB) 13.8
 LDTP11259  Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase (ALG12) 13.6
 LDTP00877  Protein SCO2 homolog, mitochondrial (SCO2) 13.5
 LDTP00544  Sphingolipid delta(4)-desaturase DES1 (DEGS1) 13.5
 LDTP10032  7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) 13.5
 LDTP03518  Enoyl-CoA hydratase, mitochondrial (ECHS1) 13.5
 LDTP10550  Dehydrogenase/reductase SDR family member 1 (DHRS1) 13.4
 LDTP08617  Patatin-like phospholipase domain-containing protein 6 (PNPLA6) 13.4
 LDTP07154  ATPase family AAA domain-containing protein 3B (ATAD3B) 13.2
 LDTP03394  Ceramide synthase 1 (CERS1) 13.2
 LDTP15422  Prostaglandin reductase 3 (PTGR3) 13.2
 LDTP02150  ATP synthase subunit beta, mitochondrial (ATP5F1B) 12.9
 LDTP09396  Minor histocompatibility antigen H13 (HM13) 12.9
 LDTP00950  Dynamin-like 120 kDa protein, mitochondrial (OPA1) 12.7
 LDTP06307  Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1) 12.7
 LDTP01300  Cartilage-associated protein (CRTAP) 12.6
 LDTP02005  Lysosomal acid glucosylceramidase (GBA1) 12.6
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 12.6
 LDTP10966  Microsomal glutathione S-transferase 2 (MGST2) 12.6
 LDTP05476  3-ketodihydrosphingosine reductase (KDSR) 12.5
 LDTP12253  Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM) 12.5
 LDTP05624  Polypeptide N-acetylgalactosaminyltransferase 1 (GALNT1) 12.5
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 12.4
 LDTP13620  Lysosomal thioesterase PPT2 (PPT2) 12.4
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 12.3
 LDTP15097  All-trans-retinol 13,14-reductase (RETSAT) 12.1
 LDTP04646  Delta-1-pyrroline-5-carboxylate synthase (ALDH18A1) 12.1
 LDTP09110  NAD(P)H-hydrate epimerase (NAXE) 12.1
 LDTP10862  Proteasome subunit beta type-7 (PSMB7) 12.1
 LDTP07227  Threonylcarbamoyladenosine tRNA methylthiotransferase (CDKAL1) 12.1
 LDTP02254  ATP-dependent translocase ABCB1 (ABCB1) 12.0
 LDTP12608  Phosphatidylinositol-3-phosphatase SAC1 (SACM1L) 12.0
 LDTP02721  Farnesyl pyrophosphate synthase (FDPS) 11.9
 LDTP13957  Ubiquitin-conjugating enzyme E2 J1 (UBE2J1) 11.9
 LDTP06905  Acylglycerol kinase, mitochondrial (AGK) 11.8
 LDTP19745  ADP-ribosylation factor-like protein 10 (ARL10) 11.8
 LDTP01502  NADH dehydrogenase 1 beta subcomplex subunit 6 (NDUFB6) 11.8
 LDTP00988  Protein O-GlcNAcase (OGA) 11.7
 LDTP15484  Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) 11.7
 LDTP03854  Vitamin K-dependent gamma-carboxylase (GGCX) 11.7
 LDTP12720  Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) 11.6
 LDTP07756  Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 (HACD2) 11.6
 LDTP03813  Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial (CPOX) 11.4
 LDTP01562  Peptidyl-prolyl cis-trans isomerase FKBP9 (FKBP9) 11.4
 LDTP06810  Mitochondrial import inner membrane translocase subunit TIM50 (TIMM50) 11.3
 LDTP03912  Trifunctional enzyme subunit alpha, mitochondrial (HADHA) 11.3
 LDTP00831  NADH dehydrogenase 1 beta subcomplex subunit 5, mitochondrial (NDUFB5) 11.2
 LDTP03592  Ribonucleoside-diphosphate reductase subunit M2 (RRM2) 11.2
 LDTP00464  Glutathione S-transferase 3, mitochondrial (MGST3) 11.2
 LDTP05588  RNA cytosine C(5)-methyltransferase NSUN2 (NSUN2) 11.2
 LDTP09835  GPI-anchor transamidase (PIGK) 11.0
 LDTP10930  Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (PKMYT1) 11.0
 LDTP00890  S-adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) 11.0
 LDTP04032  Glycerol-3-phosphate dehydrogenase, mitochondrial (GPD2) 10.9
 LDTP12470  GTP-binding protein SAR1a (SAR1A) 10.9
 LDTP14141  Mannose-1-phosphate guanyltransferase beta (GMPPB) 10.9
 LDTP08530  Mitofusin-1 (MFN1) 10.9
 LDTP02848  NADPH--cytochrome P450 reductase (POR) 10.9
 LDTP06283  Exosome complex component RRP42 (EXOSC7) 10.9
 LDTP10188  FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1) 10.8
 LDTP13220  Phosphatidylserine decarboxylase proenzyme, mitochondrial (PISD) 10.8
 LDTP12040  Prostaglandin E synthase 2 (PTGES2) 10.7
Transporter and channel
Click to Show/Hide to Show 130 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP15648  BRI3-binding protein (BRI3BP) 99.7
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 99.7
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 99.7
 LDTP01804  ATP synthase subunit a (MT-ATP6) 78.2
 LDTP08881  Transmembrane protein 199 (TMEM199) 71.0
 LDTP08981  Cytochrome c oxidase assembly protein COX18, mitochondrial (COX18) 58.5
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 54.2
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 49.9
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 48.5
 LDTP15948  Transmembrane protein 126A (TMEM126A) 46.2
 LDTP12207  Putative divalent cation/proton antiporter TMEM165 (TMEM165) 45.6
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 41.9
 LDTP01671  STARD3 N-terminal-like protein (STARD3NL) 40.5
 LDTP05900  Metaxin-1 (MTX1) 38.9
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 38.3
 LDTP15481  Transmembrane protein 87A (TMEM87A) 35.8
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 35.5
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 34.1
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 32.9
 LDTP10065  Transmembrane protein 230 (TMEM230) 32.0
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 31.6
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 30.9
 LDTP20002  Transmembrane protein 160 (TMEM160) 30.7
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 30.3
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 30.3
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 30.1
 LDTP00477  Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23) 30.1
 LDTP07467  Rhomboid domain-containing protein 2 (RHBDD2) 30.1
 LDTP07236  Protein GPR107 (GPR107) 29.9
 LDTP06308  Mitochondrial inner membrane protein OXA1L (OXA1L) 28.2
 LDTP01200  Peroxisomal membrane protein PEX14 (PEX14) 28.1
 LDTP07667  Transmembrane protein 205 (TMEM205) 27.9
 LDTP08469  Complex I assembly factor TMEM126B, mitochondrial (TMEM126B) 27.7
 LDTP14200  Mitochondrial ornithine transporter 1 (SLC25A15) 27.7
 LDTP13983  Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) 27.3
 LDTP11095  Mitochondrial 2-oxodicarboxylate carrier (SLC25A21) 27.1
 LDTP00235  Membrane-associated progesterone receptor component 1 (PGRMC1) 26.9
 LDTP10059  PAT complex subunit CCDC47 (CCDC47) 26.4
 LDTP11626  Protein YIPF3 (YIPF3) 25.6
 LDTP07490  Zinc transporter 6 (SLC30A6) 25.3
 LDTP03546  Translocator protein (TSPO) 24.8
 LDTP01745  Putative lipid scramblase CLPTM1 (CLPTM1) 24.1
 LDTP11162  Solute carrier family 25 member 33 (SLC25A33) 23.6
 LDTP06855  Anoctamin-6 (ANO6) 23.4
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 23.3
 LDTP12909  Mitochondrial carrier homolog 1 (MTCH1) 22.8
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) 22.8
 LDTP02645  Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1) 22.6
 LDTP11136  Sugar transporter SWEET1 (SLC50A1) 21.0
 LDTP04789  Synaptojanin-2-binding protein (SYNJ2BP) 20.4
 LDTP10499  Lipid scramblase CLPTM1L (CLPTM1L) 20.1
 LDTP11213  Nucleoporin NDC1 (NDC1) 20.1
 LDTP05511  Cytoskeleton-associated protein 4 (CKAP4) 19.8
 LDTP11826  Sodium-dependent neutral amino acid transporter B(0)AT2 (SLC6A15) 19.7
 LDTP06221  StAR-related lipid transfer protein 3 (STARD3) 19.6
 LDTP16813  Tetraspanin-3 (TSPAN3) 19.6
 LDTP14235  Mitochondrial carrier homolog 2 (MTCH2) 19.3
 LDTP00262  Acetyl-coenzyme A transporter 1 (SLC33A1) 18.9
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 18.9
 LDTP04592  Monocarboxylate transporter 1 (SLC16A1) 18.5
 LDTP01525  Mitochondrial proton/calcium exchanger protein (LETM1) 18.3
 LDTP05780  Syntaxin-5 (STX5) 18.3
 LDTP11869  Growth hormone-inducible transmembrane protein (GHITM) 17.9
 LDTP01380  Wolframin (WFS1) 17.8
 LDTP10081  Leucine-rich repeat-containing protein 59 (LRRC59) 17.6
 LDTP06365  Transmembrane emp24 domain-containing protein 2 (TMED2) 17.6
 LDTP02608  ADP/ATP translocase 1 (SLC25A4) 17.5
 LDTP11615  Protein tweety homolog 3 (TTYH3) 17.4
 LDTP18459  StAR-related lipid transfer protein 7, mitochondrial (STARD7) 17.4
 LDTP03284  ATP synthase F(0) complex subunit B1, mitochondrial (ATP5PB) 17.0
 LDTP09968  V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) 17.0
 LDTP13164  Protein sel-1 homolog 1 (SEL1L) 16.9
 LDTP10669  Melanoma inhibitory activity protein 2 (MIA2) 16.4
 LDTP10804  Chloride channel CLIC-like protein 1 (CLCC1) 16.1
 LDTP12210  Mitochondrial thiamine pyrophosphate carrier (SLC25A19) 16.0
 LDTP02215  Prosaposin (PSAP) 15.9
 LDTP03327  ATP synthase subunit alpha, mitochondrial (ATP5F1A) 15.8
 LDTP07058  Transmembrane protein 201 (TMEM201) 15.8
 LDTP00592  Surfeit locus protein 4 (SURF4) 15.3
 LDTP03905  Peroxisomal biogenesis factor 19 (PEX19) 14.9
 LDTP00590  Protein RER1 (RER1) 14.8
 LDTP03405  Calnexin (CANX) 14.6
 LDTP00821  Mitochondrial import inner membrane translocase subunit TIM44 (TIMM44) 14.6
 LDTP09294  Proton-coupled zinc antiporter SLC30A5 (SLC30A5) 14.5
 LDTP09328  Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) 14.2
 LDTP03810  ATP synthase subunit gamma, mitochondrial (ATP5F1C) 14.2
 LDTP14084  Sorting and assembly machinery component 50 homolog (SAMM50) 14.0
 LDTP06293  Metal cation symporter ZIP14 (SLC39A14) 13.9
 LDTP15967  Tetraspanin-10 (TSPAN10) 13.9
 LDTP11250  MICOS complex subunit MIC26 (APOO) 13.8
 LDTP13943  Thioredoxin-related transmembrane protein 2 (TMX2) 13.8
 LDTP12331  Endoplasmic reticulum membrane protein complex subunit 7 (EMC7) 13.5
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 13.4
 LDTP08279  Mitochondrial coenzyme A transporter SLC25A42 (SLC25A42) 13.1
 LDTP15838  Translocation protein SEC62 (SEC62) 13.1
 LDTP08673  Calcium uptake protein 2, mitochondrial (MICU2) 12.9
 LDTP03869  Protein Mpv17 (MPV17) 12.9
 LDTP05116  CMP-sialic acid transporter (SLC35A1) 12.7
 LDTP14174  Sorting nexin-5 (SNX5) 12.7
 LDTP07477  Transmembrane protein 214 (TMEM214) 12.6
 LDTP07472  Mitochondrial adenyl nucleotide antiporter SLC25A24 (SLC25A24) 12.6
 LDTP01217  Metaxin-2 (MTX2) 12.3
 LDTP15845  Transmembrane 9 superfamily member 2 (TM9SF2) 12.3
 LDTP11406  Transmembrane protein 59 (TMEM59) 12.3
 LDTP10621  Sideroflexin-2 (SFXN2) 12.2
 LDTP11732  Magnesium transporter protein 1 (MAGT1) 12.1
 LDTP02057  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (RPN1) 12.0
 LDTP13393  Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial (SLC25A13) 12.0
 LDTP09144  Metal transporter CNNM3 (CNNM3) 12.0
 LDTP17362  Magnesium transporter NIPA3 (NIPAL1) 11.9
 LDTP08769  Nuclear pore complex protein Nup93 (NUP93) 11.7
 LDTP04459  H(+)/Cl(-) exchange transporter 3 (CLCN3) 11.5
 LDTP00547  Secretory carrier-associated membrane protein 2 (SCAMP2) 11.5
 LDTP04293  Transmembrane emp24 domain-containing protein 10 (TMED10) 11.5
 LDTP09288  Vang-like protein 1 (VANGL1) 11.5
 LDTP11281  Voltage-gated monoatomic cation channel TMEM109 (TMEM109) 11.5
 LDTP00541  NPC intracellular cholesterol transporter 1 (NPC1) 11.4
 LDTP14181  Peroxisomal membrane protein PEX16 (PEX16) 11.4
 LDTP12704  Anoctamin-10 (ANO10) 11.3
 LDTP11245  Derlin-1 (DERL1) 11.3
 LDTP06994  ER membrane protein complex subunit 4 (EMC4) 11.3
 LDTP11116  45 kDa calcium-binding protein (SDF4) 11.2
 LDTP02609  ADP/ATP translocase 3 (SLC25A6) 11.2
 LDTP12451  Integral membrane protein 2C (ITM2C) 11.2
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 11.1
 LDTP16069  Peroxisomal membrane protein 2 (PXMP2) 10.9
 LDTP13969  Transmembrane emp24 domain-containing protein 7 (TMED7) 10.9
 LDTP05510  Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP) 10.9
 LDTP04787  Transmembrane protein 33 (TMEM33) 10.9
 LDTP04426  B-cell receptor-associated protein 31 (BCAP31) 10.7
Transcription factor
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10501  DnaJ homolog subfamily C member 1 (DNAJC1) 13.2
 LDTP10507  Zinc finger protein 512B (ZNF512B) 10.9
Immunoglobulin
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05572  Leukocyte surface antigen CD47 (CD47) 15.3
 LDTP03772  Basigin (BSG) 14.5
Other
Click to Show/Hide to Show 133 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP11674  Extracellular glycoprotein lacritin (LACRT) 99.7
 LDTP03571  Lipocalin-1 (LCN1) 99.7
 LDTP10056  Protein FAM162A (FAM162A) 99.7
 LDTP05868  Protein unc-119 homolog A (UNC119) 86.8
 LDTP01522  Reticulon-3 (RTN3) 82.7
 LDTP13902  Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) 77.2
 LDTP12412  Reticulon-4 (RTN4) 60.5
 LDTP15269  Large ribosomal subunit protein mL55 (MRPL55) 60.1
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 53.4
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 52.3
 LDTP13086  Syntaxin-18 (STX18) 50.9
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 50.2
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 47.2
 LDTP16323  Signal recognition particle receptor subunit beta (SRPRB) 46.9
 LDTP19963  TraB domain-containing protein (TRABD) 45.6
 LDTP08224  Protein LYRIC (MTDH) 44.0
 LDTP05160  Nucleobindin-2 (NUCB2) 39.9
 LDTP18373  Thioredoxin-related transmembrane protein 4 (TMX4) 35.3
 LDTP18467  LYR motif-containing protein 2 (LYRM2) 34.5
 LDTP11009  Opiorphin prepropeptide (OPRPN) 34.5
 LDTP08919  COMM domain-containing protein 1 (COMMD1) 34.3
 LDTP08689  Dyslexia-associated protein KIAA0319-like protein (KIAA0319L) 34.1
 LDTP14458  Tetraspanin-6 (TSPAN6) 32.7
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 32.4
 LDTP00105  Protein unc-119 homolog B (UNC119B) 32.0
 LDTP03678  ER lumen protein-retaining receptor 2 (KDELR2) 31.6
 LDTP13311  Poly(U)-binding-splicing factor PUF60 (PUF60) 31.6
 LDTP00986  Syntaxin-10 (STX10) 30.1
 LDTP16006  Optic atrophy 3 protein (OPA3) 29.9
 LDTP06097  Reticulocalbin-2 (RCN2) 29.9
 LDTP12395  Large ribosomal subunit protein mL40 (MRPL40) 29.0
 LDTP01167  Reticulon-2 (RTN2) 28.2
 LDTP11076  Apolipoprotein L2 (APOL2) 27.7
 LDTP10357  RUS family member 1 (RUSF1) 27.7
 LDTP13425  U6 snRNA-associated Sm-like protein LSm7 (LSM7) 27.7
 LDTP14939  Membralin (TMEM259) 27.3
 LDTP15240  LysM and putative peptidoglycan-binding domain-containing protein 3 (LYSMD3) 26.5
 LDTP16192  Mitochondrial fission process protein 1 (MTFP1) 25.6
 LDTP16080  Protein FAM114A2 (FAM114A2) 25.6
 LDTP08248  NLR family member X1 (NLRX1) 24.3
 LDTP08796  Protein SYS1 homolog (SYS1) 23.1
 LDTP08130  Rab9 effector protein with kelch motifs (RABEPK) 22.9
 LDTP03968  Lamina-associated polypeptide 2, isoforms beta/gamma (TMPO) 22.6
 LDTP15712  RING finger and SPRY domain-containing protein 1 (RSPRY1) 22.3
 LDTP18883  Protein CEBPZOS (CEBPZOS) 20.8
 LDTP05375  Nucleobindin-1 (NUCB1) 19.7
 LDTP12982  Mitochondrial import receptor subunit TOM7 homolog (TOMM7) 19.4
 LDTP10093  Mitochondrial calcium uniporter regulator 1 (MCUR1) 19.3
 LDTP11906  Phosphatidylinositol glycan anchor biosynthesis class U protein (PIGU) 18.6
 LDTP09069  Kinetochore protein Spc24 (SPC24) 18.5
 LDTP12755  OCIA domain-containing protein 1 (OCIAD1) 18.5
 LDTP02124  Keratin, type I cytoskeletal 18 (KRT18) 18.3
 LDTP07274  MICOS complex subunit MIC13 (MICOS13) 18.1
 LDTP00859  Synaptogyrin-2 (SYNGR2) 18.0
 LDTP15253  HEAT repeat-containing protein 3 (HEATR3) 17.4
 LDTP00500  Heterogeneous nuclear ribonucleoprotein D-like (HNRNPDL) 17.3
 LDTP06291  ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL6IP1) 17.1
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 17.1
 LDTP07598  BRCA1-associated ATM activator 1 (BRAT1) 17.1
 LDTP15434  ADP-ribosylation factor-like protein 6-interacting protein 6 (ARL6IP6) 16.9
 LDTP04015  Platelet-activating factor acetylhydrolase IB subunit beta (PAFAH1B1) 16.7
 LDTP07891  Inhibitor of nuclear factor kappa-B kinase-interacting protein (IKBIP) 16.2
 LDTP00887  Calumenin (CALU) 16.1
 LDTP19021  EF-hand calcium-binding domain-containing protein 14 (EFCAB14) 16.1
 LDTP04356  Emerin (EMD) 16.0
 LDTP11911  Golgi phosphoprotein 3 (GOLPH3) 16.0
 LDTP08904  Protein jagunal homolog 1 (JAGN1) 16.0
 LDTP14126  Mitochondrial import inner membrane translocase subunit Tim9 (TIMM9) 15.9
 LDTP04684  Nucleosome assembly protein 1-like 1 (NAP1L1) 15.5
 LDTP05715  Vesicle transport protein SEC20 (BNIP1) 15.5
 LDTP10965  Nucleosome assembly protein 1-like 4 (NAP1L4) 15.0
 LDTP11981  Receptor expression-enhancing protein 4 (REEP4) 14.9
 LDTP11978  HAUS augmin-like complex subunit 4 (HAUS4) 14.5
 LDTP10775  Endoplasmic reticulum-Golgi intermediate compartment protein 2 (ERGIC2) 14.3
 LDTP16116  BSD domain-containing protein 1 (BSDC1) 14.2
 LDTP11421  Fanconi anemia group D2 protein (FANCD2) 14.2
 LDTP13908  AP-3 complex subunit mu-1 (AP3M1) 13.9
 LDTP02297  Vimentin (VIM) 13.9
 LDTP15398  Protein FAM177A1 (FAM177A1) 13.8
 LDTP09325  Iron-sulfur cluster transfer protein NUBPL (NUBPL) 13.6
 LDTP10469  Engulfment and cell motility protein 2 (ELMO2) 13.5
 LDTP15623  Neuferricin (CYB5D2) 13.5
 LDTP01466  HAUS augmin-like complex subunit 5 (HAUS5) 13.4
 LDTP11277  Tubulin beta-2B chain (TUBB2B) 13.4
 LDTP19005  SLC35A4 upstream open reading frame protein (SLC35A4) 13.2
 LDTP05076  Tubulin beta-4B chain (TUBB4B) 13.2
 LDTP08420  BLOC-2 complex member HPS6 (HPS6) 13.1
 LDTP13622  NFU1 iron-sulfur cluster scaffold homolog, mitochondrial (NFU1) 13.1
 LDTP11389  Bcl-2-like protein 13 (BCL2L13) 13.0
 LDTP17659  ELMO domain-containing protein 2 (ELMOD2) 13.0
 LDTP16577  DENN domain-containing protein 11 (DENND11) 12.9
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) 12.8
 LDTP04714  Heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2) 12.7
 LDTP16322  Mitochondrial import inner membrane translocase subunit Tim8 B (TIMM8B) 12.7
 LDTP00991  Heterogeneous nuclear ribonucleoprotein Q (SYNCRIP) 12.6
 LDTP06587  Survival motor neuron protein (SMN1; SMN2) 12.6
 LDTP09644  m-AAA protease-interacting protein 1, mitochondrial (MAIP1) 12.4
 LDTP02205  Tubulin beta chain (TUBB) 12.4
 LDTP18272  Transmembrane protein 209 (TMEM209) 12.3
 LDTP13922  Tudor and KH domain-containing protein (TDRKH) 12.1
 LDTP05257  Receptor expression-enhancing protein 5 (REEP5) 12.0
 LDTP11159  Gamma-tubulin complex component 2 (TUBGCP2) 12.0
 LDTP00729  Glycosylphosphatidylinositol anchor attachment 1 protein (GPAA1) 12.0
 LDTP11167  Protein YIPF4 (YIPF4) 12.0
 LDTP05647  Transducin beta-like protein 3 (TBL3) 12.0
 LDTP01652  Centrosomal protein 43 (CEP43) 11.9
 LDTP03614  Heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3) 11.9
 LDTP15887  Lipase maturation factor 2 (LMF2) 11.9
 LDTP09881  TATA-binding protein-associated factor 2N (TAF15) 11.9
 LDTP03182  Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1) 11.8
 LDTP05530  Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) 11.8
 LDTP01494  Protein YIF1A (YIF1A) 11.8
 LDTP11373  Chromatin remodeling regulator CECR2 (CECR2) 11.7
 LDTP04369  Peroxisomal targeting signal 1 receptor (PEX5) 11.7
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 11.6
 LDTP11326  FUN14 domain-containing protein 2 (FUNDC2) 11.6
 LDTP05998  Tubulin beta-2A chain (TUBB2A) 11.6
 LDTP03615  Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) 11.5
 LDTP14125  Mitochondrial import inner membrane translocase subunit Tim10 B (TIMM10B) 11.5
 LDTP08300  Reticulophagy regulator 3 (RETREG3) 11.5
 LDTP14136  Mitochondrial import inner membrane translocase subunit Tim13 (TIMM13) 11.4
 LDTP10033  WW domain-binding protein 2 (WBP2) 11.2
 LDTP00756  Heterogeneous nuclear ribonucleoprotein R (HNRNPR) 11.2
 LDTP04902  Actin-related protein 3 (ACTR3) 11.1
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 11.1
 LDTP11044  Polyadenylate-binding protein-interacting protein 2 (PAIP2) 11.1
 LDTP08000  Dymeclin (DYM) 11.0
 LDTP05277  Protein SET (SET) 11.0
 LDTP13721  TBC1 domain family member 2B (TBC1D2B) 10.9
 LDTP10408  Far upstream element-binding protein 3 (FUBP3) 10.9
 LDTP12468  Diablo IAP-binding mitochondrial protein (DIABLO) 10.7
 LDTP04652  Eukaryotic translation initiation factor 5 (EIF5) 10.7
 LDTP15793  Protein FAM210A (FAM210A) 10.7

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587