Details of the Target

General Information of Target

Target ID LDTP14126
Target Name Mitochondrial import inner membrane translocase subunit Tim9 (TIMM9)
Gene Name TIMM9
Gene ID 26520
Synonyms
TIM9; TIM9A; TIMM9A; Mitochondrial import inner membrane translocase subunit Tim9
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MERQQQQQQQLRNLRDFLLVYNRMTELCFQRCVPSLHHRALDAEEEACLHSCAGKLIHSN
HRLMAAYVQLMPALVQRRIADYEAASAVPGVAAEQPGVSPSGS
Target Bioclass
Other
Family
Small Tim family
Subcellular location
Mitochondrion inner membrane
Function
Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
Uniprot ID
Q9Y5J7
Ensemble ID
ENST00000395159.7
HGNC ID
HGNC:11819

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K81(20.00)  LDD2218  [1]
Probe 1
 Probe Info  		Y21(57.17); Y70(13.09)  LDD3495  [2]
BTD
 Probe Info  		C48(0.74)  LDD2100  [3]
DBIA
 Probe Info  		C48(1.28)  LDD1571  [4]
5E-2FA
 Probe Info  		N.A.  LDD2235  [5]
m-APA
 Probe Info  		N.A.  LDD2231  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0175  [6]
1d-yne
 Probe Info  		N.A.  LDD0356  [7]
1c-yne
 Probe Info  		N.A.  LDD0228  [7]
Acrolein
 Probe Info  		H71(0.00); H51(0.00)  LDD0217  [8]
Methacrolein
 Probe Info  		C48(0.00); C28(0.00); C52(0.00)  LDD0218  [8]
NAIA_5
 Probe Info  		C32(0.00); C48(0.00); C28(0.00)  LDD2223  [9]
PAL-AfBPP Probe
Click To Hide/Show 22 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C056
 Probe Info  		37.79  LDD1753  [10]
C112
 Probe Info  		47.84  LDD1799  [10]
C159
 Probe Info  		8.22  LDD1839  [10]
C160
 Probe Info  		7.62  LDD1840  [10]
C161
 Probe Info  		22.94  LDD1841  [10]
C218
 Probe Info  		15.89  LDD1892  [10]
C220
 Probe Info  		38.05  LDD1894  [10]
C228
 Probe Info  		15.24  LDD1901  [10]
C243
 Probe Info  		12.30  LDD1916  [10]
C244
 Probe Info  		17.75  LDD1917  [10]
C246
 Probe Info  		15.03  LDD1919  [10]
C313
 Probe Info  		15.78  LDD1980  [10]
C343
 Probe Info  		13.00  LDD2005  [10]
C348
 Probe Info  		13.09  LDD2009  [10]
C349
 Probe Info  		14.22  LDD2010  [10]
C350
 Probe Info  		51.63  LDD2011  [10]
C353
 Probe Info  		6.28  LDD2014  [10]
C362
 Probe Info  		56.10  LDD2023  [10]
C364
 Probe Info  		21.41  LDD2025  [10]
C383
 Probe Info  		14.42  LDD2042  [10]
C386
 Probe Info  		6.82  LDD2045  [10]
C388
 Probe Info  		84.45  LDD2047  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C52(0.73); C48(0.81); C32(0.81)  LDD2112  [3]
 LDCM0520  AKOS000195272 MDA-MB-231 C48(0.77)  LDD2113  [3]
 LDCM0108  Chloroacetamide HeLa C32(0.00); H71(0.00); C28(0.00); H51(0.00)  LDD0222  [8]
 LDCM0367  CL1 HEK-293T C48(1.28)  LDD1571  [4]
 LDCM0370  CL101 HEK-293T C48(1.38)  LDD1574  [4]
 LDCM0374  CL105 HEK-293T C48(1.48)  LDD1578  [4]
 LDCM0378  CL109 HEK-293T C48(1.03)  LDD1582  [4]
 LDCM0383  CL113 HEK-293T C48(1.10)  LDD1587  [4]
 LDCM0387  CL117 HEK-293T C48(1.17)  LDD1591  [4]
 LDCM0392  CL121 HEK-293T C48(1.39)  LDD1596  [4]
 LDCM0396  CL125 HEK-293T C48(1.14)  LDD1600  [4]
 LDCM0400  CL13 HEK-293T C48(1.04)  LDD1604  [4]
 LDCM0413  CL25 HEK-293T C48(1.16)  LDD1617  [4]
 LDCM0426  CL37 HEK-293T C48(1.18)  LDD1630  [4]
 LDCM0439  CL49 HEK-293T C48(1.24)  LDD1643  [4]
 LDCM0453  CL61 HEK-293T C48(1.35)  LDD1656  [4]
 LDCM0466  CL73 HEK-293T C48(1.12)  LDD1669  [4]
 LDCM0479  CL85 HEK-293T C48(1.03)  LDD1682  [4]
 LDCM0492  CL97 HEK-293T C48(1.16)  LDD1695  [4]
 LDCM0107  IAA HeLa H71(0.00); H51(0.00)  LDD0221  [8]
 LDCM0109  NEM HeLa N.A.  LDD0223  [8]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C48(0.74)  LDD2100  [3]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C48(1.12)  LDD2101  [3]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C48(0.48)  LDD2104  [3]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C48(0.61); C32(0.54)  LDD2106  [3]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C48(0.74); C32(0.67)  LDD2110  [3]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C48(0.80)  LDD2114  [3]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C52(0.98); C48(0.77)  LDD2115  [3]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C52(0.46); C48(0.67)  LDD2134  [3]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C52(0.44)  LDD2148  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mitochondrial import inner membrane translocase subunit Tim10 (TIMM10) Small Tim family P62072

References

1 Global profiling of lysine reactivity and ligandability in the human proteome. Nat Chem. 2017 Dec;9(12):1181-1190. doi: 10.1038/nchem.2826. Epub 2017 Jul 31.
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
5 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587