Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C243  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 101 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP00697  Cytochrome b5 type B (CYB5B) 64.9
 LDTP06618  ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) 54.9
 LDTP14218  Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) 52.7
 LDTP17247  5'-nucleotidase domain-containing protein 1 (NT5DC1) 49.5
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 48.2
 LDTP03540  Heme oxygenase 2 (HMOX2) 40.5
 LDTP07831  Transmembrane protein with metallophosphoesterase domain (TMPPE) 39.1
 LDTP16040  Glyoxalase domain-containing protein 4 (GLOD4) 36.5
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 35.0
 LDTP02505  Lysosomal protective protein (CTSA) 34.8
 LDTP06150  DNA replication licensing factor MCM6 (MCM6) 34.3
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 32.7
 LDTP08385  NADH dehydrogenase 1 alpha subcomplex subunit 11 (NDUFA11) 32.2
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 30.1
 LDTP00486  Cytochrome b-c1 complex subunit 8 (UQCRQ) 29.4
 LDTP10188  FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1) 28.1
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 26.4
 LDTP15480  Prenylcysteine oxidase-like (PCYOX1L) 26.4
 LDTP12720  Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) 23.9
 LDTP02896  Sphingomyelin phosphodiesterase (SMPD1) 23.6
 LDTP04437  Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) 23.4
 LDTP03985  Caspase-2 (CASP2) 22.0
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 21.9
 LDTP05066  Signal peptidase complex catalytic subunit SEC11A (SEC11A) 21.1
 LDTP01982  NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) 21.0
 LDTP12586  Phenylalanine--tRNA ligase beta subunit (FARSB) 20.8
 LDTP15328  Dolichyldiphosphatase 1 (DOLPP1) 20.7
 LDTP17410  Cytochrome P450 20A1 (CYP20A1) 20.5
 LDTP05905  Acid ceramidase (ASAH1) 20.3
 LDTP04565  Methionine aminopeptidase 1 (METAP1) 20.0
 LDTP10699  E3 ubiquitin-protein ligase NEDD4-like (NEDD4L) 19.0
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 19.0
 LDTP09096  Carbohydrate sulfotransferase 14 (CHST14) 18.9
 LDTP10329  Ceramide synthase 2 (CERS2) 18.8
 LDTP10550  Dehydrogenase/reductase SDR family member 1 (DHRS1) 18.8
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 18.3
 LDTP05476  3-ketodihydrosphingosine reductase (KDSR) 18.1
 LDTP02005  Lysosomal acid glucosylceramidase (GBA1) 18.0
 LDTP02359  Heme oxygenase 1 (HMOX1) 17.8
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 17.5
 LDTP06787  Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) 17.1
 LDTP12873  CDGSH iron-sulfur domain-containing protein 1 (CISD1) 16.7
 LDTP09256  Putative phospholipase B-like 2 (PLBD2) 16.4
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 16.2
 LDTP08455  Palmitoyltransferase ZDHHC13 (ZDHHC13) 16.1
 LDTP00428  Tripeptidyl-peptidase 1 (TPP1) 16.1
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 16.0
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 15.9
 LDTP19745  ADP-ribosylation factor-like protein 10 (ARL10) 15.8
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 15.6
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 15.2
 LDTP08790  Mitochondrial cardiolipin hydrolase (PLD6) 15.1
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 14.8
 LDTP00907  Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D) 14.3
 LDTP02223  Cathepsin B (CTSB) 14.1
 LDTP02254  ATP-dependent translocase ABCB1 (ABCB1) 14.0
 LDTP11437  Peroxisomal trans-2-enoyl-CoA reductase (PECR) 14.0
 LDTP12318  Calcium-independent phospholipase A2-gamma (PNPLA8) 13.8
 LDTP01389  Delta(14)-sterol reductase TM7SF2 (TM7SF2) 13.6
 LDTP01769  Dihydrofolate reductase (DHFR) 13.5
 LDTP10612  Lysophospholipid acyltransferase 7 (MBOAT7) 13.5
 LDTP11273  N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) 13.5
 LDTP04531  Hexokinase-2 (HK2) 13.4
 LDTP12959  NADH dehydrogenase 1 alpha subcomplex subunit 13 (NDUFA13) 13.4
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 13.3
 LDTP15484  Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) 13.0
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 12.8
 LDTP01613  Sphingosine-1-phosphate lyase 1 (SGPL1) 12.8
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 12.7
 LDTP02260  Beta-glucuronidase (GUSB) 12.6
 LDTP05408  Antigen peptide transporter 1 (TAP1) 12.6
 LDTP04384  Cyclin-dependent kinase 9 (CDK9) 12.5
 LDTP12868  Endoplasmic reticulum aminopeptidase 1 (ERAP1) 12.5
 LDTP13814  Phospholipase A-2-activating protein (PLAA) 12.3
 LDTP09251  Atlastin-2 (ATL2) 12.2
 LDTP03145  Catechol O-methyltransferase (COMT) 12.2
 LDTP03189  Cytochrome b-c1 complex subunit 2, mitochondrial (UQCRC2) 12.2
 LDTP10020  Ras-related protein Rab-24 (RAB24) 12.0
 LDTP06617  Ceramide glucosyltransferase (UGCG) 11.9
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 11.9
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 11.9
 LDTP01462  Endonuclease domain-containing 1 protein (ENDOD1) 11.8
 LDTP08598  NAD-dependent protein deacetylase sirtuin-2 (SIRT2) 11.7
 LDTP04358  Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A) 11.6
 LDTP13486  Long-chain-fatty-acid--CoA ligase 6 (ACSL6) 11.6
 LDTP13620  Lysosomal thioesterase PPT2 (PPT2) 11.6
 LDTP00032  2-hydroxyacyl-CoA lyase 2 (ILVBL) 11.6
 LDTP06477  Methylsterol monooxygenase 1 (MSMO1) 11.5
 LDTP02067  Sodium/potassium-transporting ATPase subunit alpha-1 (ATP1A1) 11.5
 LDTP05624  Polypeptide N-acetylgalactosaminyltransferase 1 (GALNT1) 11.4
 LDTP11127  ADP-dependent glucokinase (ADPGK) 11.2
 LDTP05638  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 (ST3GAL4) 11.1
 LDTP01168  NADH dehydrogenase iron-sulfur protein 2, mitochondrial (NDUFS2) 11.1
 LDTP04581  Holocytochrome c-type synthase (HCCS) 11.0
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 11.0
 LDTP07868  Protein O-mannosyl-transferase TMTC3 (TMTC3) 11.0
 LDTP12681  ATPase family AAA domain-containing protein 3A (ATAD3A) 10.9
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 10.9
 LDTP06270  Signal peptidase complex subunit 2 (SPCS2) 10.9
 LDTP01560  NADH dehydrogenase 1 subunit C2 (NDUFC2) 10.7
 LDTP02860  Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) 10.7
Transporter and channel
Click to Show/Hide to Show 76 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 81.0
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 59.7
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 54.9
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 53.8
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 50.9
 LDTP15481  Transmembrane protein 87A (TMEM87A) 43.1
 LDTP15948  Transmembrane protein 126A (TMEM126A) 42.8
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 42.2
 LDTP08881  Transmembrane protein 199 (TMEM199) 40.2
 LDTP16813  Tetraspanin-3 (TSPAN3) 37.8
 LDTP07236  Protein GPR107 (GPR107) 37.0
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 36.8
 LDTP01804  ATP synthase subunit a (MT-ATP6) 36.5
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 35.3
 LDTP05900  Metaxin-1 (MTX1) 33.4
 LDTP04956  Mitochondrial import inner membrane translocase subunit Tim10 (TIMM10) 32.2
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 31.8
 LDTP00010  Intraflagellar transport protein 56 (IFT56) 28.4
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 28.2
 LDTP18153  Major facilitator superfamily domain-containing protein 3 (MFSD3) 27.1
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 26.7
 LDTP07156  Protein wntless homolog (WLS) 25.8
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 24.8
 LDTP20002  Transmembrane protein 160 (TMEM160) 23.1
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 21.1
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 21.0
 LDTP02215  Prosaposin (PSAP) 20.3
 LDTP00477  Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23) 19.8
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 19.4
 LDTP13983  Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) 18.6
 LDTP01745  Putative lipid scramblase CLPTM1 (CLPTM1) 18.0
 LDTP15648  BRI3-binding protein (BRI3BP) 17.8
 LDTP13833  Integral membrane protein 2B (ITM2B) 17.8
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 17.8
 LDTP01542  Golgi SNAP receptor complex member 1 (GOSR1) 17.1
 LDTP16190  Protein FAM8A1 (FAM8A1) 17.0
 LDTP09333  Golgin subfamily A member 5 (GOLGA5) 16.6
 LDTP06365  Transmembrane emp24 domain-containing protein 2 (TMED2) 16.4
 LDTP00541  NPC intracellular cholesterol transporter 1 (NPC1) 16.2
 LDTP11615  Protein tweety homolog 3 (TTYH3) 16.2
 LDTP10065  Transmembrane protein 230 (TMEM230) 16.1
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) 15.9
 LDTP06308  Mitochondrial inner membrane protein OXA1L (OXA1L) 15.8
 LDTP11213  Nucleoporin NDC1 (NDC1) 15.2
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 14.9
 LDTP04459  H(+)/Cl(-) exchange transporter 3 (CLCN3) 14.5
 LDTP00592  Surfeit locus protein 4 (SURF4) 14.0
 LDTP11245  Derlin-1 (DERL1) 13.9
 LDTP03559  High affinity cationic amino acid transporter 1 (SLC7A1) 13.9
 LDTP09294  Proton-coupled zinc antiporter SLC30A5 (SLC30A5) 13.9
 LDTP10059  PAT complex subunit CCDC47 (CCDC47) 13.7
 LDTP10499  Lipid scramblase CLPTM1L (CLPTM1L) 13.6
 LDTP03905  Peroxisomal biogenesis factor 19 (PEX19) 13.5
 LDTP01671  STARD3 N-terminal-like protein (STARD3NL) 13.4
 LDTP01380  Wolframin (WFS1) 13.4
 LDTP14084  Sorting and assembly machinery component 50 homolog (SAMM50) 13.1
 LDTP02645  Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1) 12.9
 LDTP14200  Mitochondrial ornithine transporter 1 (SLC25A15) 12.9
 LDTP07667  Transmembrane protein 205 (TMEM205) 12.5
 LDTP11116  45 kDa calcium-binding protein (SDF4) 12.4
 LDTP13164  Protein sel-1 homolog 1 (SEL1L) 12.4
 LDTP09288  Vang-like protein 1 (VANGL1) 12.3
 LDTP00383  AP-3 complex subunit delta-1 (AP3D1) 12.2
 LDTP03284  ATP synthase F(0) complex subunit B1, mitochondrial (ATP5PB) 12.2
 LDTP16069  Peroxisomal membrane protein 2 (PXMP2) 12.0
 LDTP10669  Melanoma inhibitory activity protein 2 (MIA2) 11.7
 LDTP07467  Rhomboid domain-containing protein 2 (RHBDD2) 11.5
 LDTP11869  Growth hormone-inducible transmembrane protein (GHITM) 11.4
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 11.4
 LDTP11162  Solute carrier family 25 member 33 (SLC25A33) 11.4
 LDTP08878  ER membrane protein complex subunit 5 (MMGT1) 10.9
 LDTP00235  Membrane-associated progesterone receptor component 1 (PGRMC1) 10.9
 LDTP11250  MICOS complex subunit MIC26 (APOO) 10.8
 LDTP06221  StAR-related lipid transfer protein 3 (STARD3) 10.7
 LDTP05667  Syntaxin-4 (STX4) 10.6
 LDTP04787  Transmembrane protein 33 (TMEM33) 10.6
Transcription factor
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10501  DnaJ homolog subfamily C member 1 (DNAJC1) 11.2
Immunoglobulin
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03772  Basigin (BSG) 12.9
Other
Click to Show/Hide to Show 79 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP16099  p53 and DNA damage-regulated protein 1 (PDRG1) 79.9
 LDTP11076  Apolipoprotein L2 (APOL2) 77.7
 LDTP05160  Nucleobindin-2 (NUCB2) 67.2
 LDTP13902  Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) 64.4
 LDTP01522  Reticulon-3 (RTN3) 61.8
 LDTP14939  Membralin (TMEM259) 49.9
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 42.2
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 34.5
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 34.3
 LDTP16006  Optic atrophy 3 protein (OPA3) 33.1
 LDTP18883  Protein CEBPZOS (CEBPZOS) 28.6
 LDTP05375  Nucleobindin-1 (NUCB1) 26.5
 LDTP18373  Thioredoxin-related transmembrane protein 4 (TMX4) 26.4
 LDTP03678  ER lumen protein-retaining receptor 2 (KDELR2) 26.2
 LDTP00986  Syntaxin-10 (STX10) 24.9
 LDTP00850  ER lumen protein-retaining receptor 3 (KDELR3) 22.6
 LDTP16080  Protein FAM114A2 (FAM114A2) 22.6
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 22.3
 LDTP13086  Syntaxin-18 (STX18) 21.9
 LDTP13019  Vacuolar protein sorting-associated protein 18 homolog (VPS18) 20.4
 LDTP12412  Reticulon-4 (RTN4) 20.3
 LDTP10056  Protein FAM162A (FAM162A) 19.8
 LDTP08154  Large ribosomal subunit protein uL10m (MRPL10) 19.3
 LDTP08796  Protein SYS1 homolog (SYS1) 19.3
 LDTP19780  Keratinocyte-associated transmembrane protein 2 (KCT2) 19.0
 LDTP00859  Synaptogyrin-2 (SYNGR2) 18.5
 LDTP14458  Tetraspanin-6 (TSPAN6) 18.3
 LDTP16192  Mitochondrial fission process protein 1 (MTFP1) 18.0
 LDTP08904  Protein jagunal homolog 1 (JAGN1) 17.6
 LDTP09870  Signal transducing adapter molecule 1 (STAM) 16.7
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 16.6
 LDTP19963  TraB domain-containing protein (TRABD) 16.6
 LDTP12982  Mitochondrial import receptor subunit TOM7 homolog (TOMM7) 16.4
 LDTP06879  Protein FAM98B (FAM98B) 16.1
 LDTP13630  Neudesin (NENF) 15.9
 LDTP19785  Transmembrane protein 35B (TMEM35B) 15.8
 LDTP03926  Centrin-2 (CETN2) 15.2
 LDTP08224  Protein LYRIC (MTDH) 15.2
 LDTP05922  Dynactin subunit 2 (DCTN2) 15.0
 LDTP10775  Endoplasmic reticulum-Golgi intermediate compartment protein 2 (ERGIC2) 14.8
 LDTP15240  LysM and putative peptidoglycan-binding domain-containing protein 3 (LYSMD3) 14.8
 LDTP17003  Matrix-remodeling-associated protein 7 (MXRA7) 14.7
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 14.5
 LDTP13606  Mammalian ependymin-related protein 1 (EPDR1) 14.4
 LDTP02927  Ganglioside GM2 activator (GM2A) 14.3
 LDTP15095  Receptor expression-enhancing protein 3 (REEP3) 13.3
 LDTP03968  Lamina-associated polypeptide 2, isoforms beta/gamma (TMPO) 13.1
 LDTP12025  UPF0488 protein C8orf33 (C8orf33) 13.1
 LDTP00871  Microtubule nucleation factor SSNA1 (SSNA1) 12.7
 LDTP07274  MICOS complex subunit MIC13 (MICOS13) 12.6
 LDTP18569  PRELI domain containing protein 3B (PRELID3B) 12.6
 LDTP06587  Survival motor neuron protein (SMN1; SMN2) 12.6
 LDTP01466  HAUS augmin-like complex subunit 5 (HAUS5) 12.4
 LDTP07192  Intermembrane lipid transfer protein VPS13D (VPS13D) 12.3
 LDTP14126  Mitochondrial import inner membrane translocase subunit Tim9 (TIMM9) 12.3
 LDTP12755  OCIA domain-containing protein 1 (OCIAD1) 12.0
 LDTP00223  26S proteasome non-ATPase regulatory subunit 11 (PSMD11) 11.9
 LDTP04951  Nuclear transport factor 2 (NUTF2) 11.8
 LDTP06097  Reticulocalbin-2 (RCN2) 11.8
 LDTP03520  Phosphatidylethanolamine-binding protein 1 (PEBP1) 11.7
 LDTP02443  Calmodulin-3 (CALM3) 11.6
 LDTP15863  Large ribosomal subunit protein mL45 (MRPL45) 11.6
 LDTP10213  Anaphase-promoting complex subunit 16 (ANAPC16) 11.5
 LDTP15868  Protein LLP homolog (LLPH) 11.4
 LDTP01163  Ubiquinone biosynthesis protein COQ9, mitochondrial (COQ9) 11.4
 LDTP13797  HIG1 domain family member 1A, mitochondrial (HIGD1A) 11.2
 LDTP01359  Dynactin subunit 3 (DCTN3) 11.2
 LDTP00199  HCLS1-associated protein X-1 (HAX1) 11.2
 LDTP01075  Protein CutA (CUTA) 11.1
 LDTP00779  Trans-Golgi network integral membrane protein 2 (TGOLN2) 11.1
 LDTP13311  Poly(U)-binding-splicing factor PUF60 (PUF60) 11.0
 LDTP10357  RUS family member 1 (RUSF1) 11.0
 LDTP00105  Protein unc-119 homolog B (UNC119B) 10.9
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 10.8
 LDTP05855  Cytoplasmic dynein 1 intermediate chain 2 (DYNC1I2) 10.7
 LDTP16116  BSD domain-containing protein 1 (BSDC1) 10.6
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 10.6
 LDTP09626  Heterogeneous nuclear ribonucleoprotein L-like (HNRNPLL) 10.6
 LDTP08300  Reticulophagy regulator 3 (RETREG3) 10.6

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587