Details of the Target

General Information of Target

Target ID LDTP07868
Target Name Protein O-mannosyl-transferase TMTC3 (TMTC3)
Gene Name TMTC3
Gene ID 160418
Synonyms
Protein O-mannosyl-transferase TMTC3; EC 2.4.1.109; Protein SMILE; Transmembrane O-mannosyltransferase targeting cadherins 3; Transmembrane and tetratricopeptide repeat-containing 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MANINLKEITLIVGVVTACYWNSLFCGFVFDDVSAILDNKDLHPSTPLKTLFQNDFWGTP
MSEERSHKSYRPLTVLTFRLNYLLSELKPMSYHLLNMIFHAVVSVIFLKVCKLFLDNKSS
VIASLLFAVHPIHTEAVTGVVGRAELLSSIFFLAAFLSYTRSKGPDNSIIWTPIALTVFL
VAVATLCKEQGITVVGICCVYEVFIAQGYTLPLLCTTAGQFLRGKGSIPFSMLQTLVKLI
VLMFSTLLLVVIRVQVIQSQLPVFTRFDNPAAVSPTPTRQLTFNYLLPVNAWLLLNPSEL
CCDWTMGTIPLIESLLDIRNLATFTFFCFLGMLGVFSIRYSGDSSKTVLMALCLMALPFI
PASNLFFPVGFVVAERVLYVPSMGFCILVAHGWQKISTKSVFKKLSWICLSMVILTHSLK
TFHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDI
GAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRA
NESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLW
YNLAIVHIELKEPNEALKKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLS
YINEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTAKEL
KALPILEELLRYYPDHIKGLILKGDILMNQKKDILGAKKCFERILEMDPSNVQGKHNLCV
VYFEEKDLLKAERCLLETLALAPHEEYIQRHLNIVRDKISSSSFIEPIFPTSKISSVEGK
KIPTESVKEIRGESRQTQIVKTSDNKSQSKSNKQLGKNGDEETPHKTTKDIKEIEKKRVA
ALKRLEEIERILNGE
Target Bioclass
Enzyme
Family
TMTC family
Subcellular location
Membrane
Function
Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl-transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O-mannosyl-transferase on other proteins such as PDIA3. Involved in the positive regulation of proteasomal protein degradation in the endoplasmic reticulum (ER), and the control of ER stress response.
Uniprot ID
Q6ZXV5
Ensemble ID
ENST00000266712.11
HGNC ID
HGNC:26899

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K563(0.99); K578(1.26); K583(4.47); K751(10.00)  LDD0277  [1]
DBIA
 Probe Info  		C779(2.47)  LDD3310  [2]
BTD
 Probe Info  		C794(0.81)  LDD2105  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [4]
IPM
 Probe Info  		N.A.  LDD0005  [5]
NAIA_5
 Probe Info  		N.A.  LDD2223  [6]
PAL-AfBPP Probe
Click To Hide/Show 27 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		6.06  LDD1714  [7]
C017
 Probe Info  		5.54  LDD1725  [7]
C022
 Probe Info  		11.63  LDD1728  [7]
C067
 Probe Info  		4.96  LDD1763  [7]
C106
 Probe Info  		49.18  LDD1793  [7]
C107
 Probe Info  		7.11  LDD1794  [7]
C108
 Probe Info  		8.28  LDD1795  [7]
C112
 Probe Info  		20.97  LDD1799  [7]
C134
 Probe Info  		20.11  LDD1816  [7]
C158
 Probe Info  		32.90  LDD1838  [7]
C161
 Probe Info  		12.91  LDD1841  [7]
C194
 Probe Info  		14.83  LDD1870  [7]
C211
 Probe Info  		8.51  LDD1885  [7]
C219
 Probe Info  		7.16  LDD1893  [7]
C220
 Probe Info  		25.11  LDD1894  [7]
C231
 Probe Info  		13.64  LDD1904  [7]
C243
 Probe Info  		11.00  LDD1916  [7]
C244
 Probe Info  		16.91  LDD1917  [7]
C265
 Probe Info  		15.45  LDD1936  [7]
C293
 Probe Info  		17.88  LDD1963  [7]
C350
 Probe Info  		65.34  LDD2011  [7]
C366
 Probe Info  		5.62  LDD2027  [7]
FFF probe11
 Probe Info  		20.00  LDD0471  [8]
FFF probe13
 Probe Info  		20.00  LDD0475  [8]
FFF probe14
 Probe Info  		20.00  LDD0477  [8]
JN0003
 Probe Info  		19.51  LDD0469  [8]
OEA-DA
 Probe Info  		10.44  LDD0046  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C794(1.08)  LDD1507  [10]
 LDCM0215  AC10 HEK-293T C794(0.91)  LDD1508  [10]
 LDCM0226  AC11 HEK-293T C794(1.11)  LDD1509  [10]
 LDCM0237  AC12 HEK-293T C794(1.17)  LDD1510  [10]
 LDCM0259  AC14 HEK-293T C794(1.20)  LDD1512  [10]
 LDCM0270  AC15 HEK-293T C794(1.19)  LDD1513  [10]
 LDCM0276  AC17 HEK-293T C794(1.15)  LDD1515  [10]
 LDCM0277  AC18 HEK-293T C794(1.05)  LDD1516  [10]
 LDCM0278  AC19 HEK-293T C794(1.10)  LDD1517  [10]
 LDCM0279  AC2 HEK-293T C794(0.80)  LDD1518  [10]
 LDCM0280  AC20 HEK-293T C794(1.21)  LDD1519  [10]
 LDCM0281  AC21 HEK-293T C794(1.10)  LDD1520  [10]
 LDCM0282  AC22 HEK-293T C794(1.23)  LDD1521  [10]
 LDCM0283  AC23 HEK-293T C794(1.16)  LDD1522  [10]
 LDCM0284  AC24 HEK-293T C794(1.17)  LDD1523  [10]
 LDCM0285  AC25 HEK-293T C794(0.94)  LDD1524  [10]
 LDCM0286  AC26 HEK-293T C794(1.06)  LDD1525  [10]
 LDCM0287  AC27 HEK-293T C794(1.08)  LDD1526  [10]
 LDCM0288  AC28 HEK-293T C794(1.27)  LDD1527  [10]
 LDCM0289  AC29 HEK-293T C794(1.05)  LDD1528  [10]
 LDCM0290  AC3 HEK-293T C794(1.32)  LDD1529  [10]
 LDCM0291  AC30 HEK-293T C794(1.34)  LDD1530  [10]
 LDCM0292  AC31 HEK-293T C794(1.15)  LDD1531  [10]
 LDCM0293  AC32 HEK-293T C794(1.11)  LDD1532  [10]
 LDCM0294  AC33 HEK-293T C794(1.04)  LDD1533  [10]
 LDCM0295  AC34 HEK-293T C794(0.93)  LDD1534  [10]
 LDCM0296  AC35 HEK-293T C794(0.77)  LDD1535  [10]
 LDCM0297  AC36 HEK-293T C794(1.17)  LDD1536  [10]
 LDCM0298  AC37 HEK-293T C794(0.93)  LDD1537  [10]
 LDCM0299  AC38 HEK-293T C794(1.12)  LDD1538  [10]
 LDCM0300  AC39 HEK-293T C794(1.03)  LDD1539  [10]
 LDCM0301  AC4 HEK-293T C794(1.39)  LDD1540  [10]
 LDCM0302  AC40 HEK-293T C794(1.07)  LDD1541  [10]
 LDCM0303  AC41 HEK-293T C794(1.15)  LDD1542  [10]
 LDCM0304  AC42 HEK-293T C794(0.90)  LDD1543  [10]
 LDCM0305  AC43 HEK-293T C794(0.98)  LDD1544  [10]
 LDCM0306  AC44 HEK-293T C794(1.20)  LDD1545  [10]
 LDCM0307  AC45 HEK-293T C794(1.06)  LDD1546  [10]
 LDCM0308  AC46 HEK-293T C794(1.36)  LDD1547  [10]
 LDCM0309  AC47 HEK-293T C794(1.28)  LDD1548  [10]
 LDCM0310  AC48 HEK-293T C794(1.16)  LDD1549  [10]
 LDCM0311  AC49 HEK-293T C794(1.21)  LDD1550  [10]
 LDCM0312  AC5 HEK-293T C794(1.08)  LDD1551  [10]
 LDCM0313  AC50 HEK-293T C794(1.01)  LDD1552  [10]
 LDCM0314  AC51 HEK-293T C794(1.09)  LDD1553  [10]
 LDCM0315  AC52 HEK-293T C794(1.35)  LDD1554  [10]
 LDCM0316  AC53 HEK-293T C794(1.02)  LDD1555  [10]
 LDCM0317  AC54 HEK-293T C794(1.11)  LDD1556  [10]
 LDCM0318  AC55 HEK-293T C794(1.17)  LDD1557  [10]
 LDCM0319  AC56 HEK-293T C794(1.02)  LDD1558  [10]
 LDCM0320  AC57 HEK-293T C794(1.12)  LDD1559  [10]
 LDCM0321  AC58 HEK-293T C794(0.87)  LDD1560  [10]
 LDCM0322  AC59 HEK-293T C794(1.14)  LDD1561  [10]
 LDCM0323  AC6 HEK-293T C794(1.16)  LDD1562  [10]
 LDCM0324  AC60 HEK-293T C794(1.29)  LDD1563  [10]
 LDCM0325  AC61 HEK-293T C794(1.01)  LDD1564  [10]
 LDCM0326  AC62 HEK-293T C794(1.23)  LDD1565  [10]
 LDCM0327  AC63 HEK-293T C794(1.13)  LDD1566  [10]
 LDCM0328  AC64 HEK-293T C794(0.94)  LDD1567  [10]
 LDCM0334  AC7 HEK-293T C794(0.94)  LDD1568  [10]
 LDCM0345  AC8 HEK-293T C794(0.92)  LDD1569  [10]
 LDCM0248  AKOS034007472 HEK-293T C794(1.08)  LDD1511  [10]
 LDCM0356  AKOS034007680 HEK-293T C794(1.21)  LDD1570  [10]
 LDCM0275  AKOS034007705 HEK-293T C794(0.86)  LDD1514  [10]
 LDCM0367  CL1 HEK-293T C794(1.22)  LDD1571  [10]
 LDCM0368  CL10 HEK-293T C794(1.44)  LDD1572  [10]
 LDCM0369  CL100 HEK-293T C794(1.00); C779(1.02)  LDD1573  [10]
 LDCM0370  CL101 HEK-293T C794(1.39)  LDD1574  [10]
 LDCM0371  CL102 HEK-293T C794(1.07); C779(1.07)  LDD1575  [10]
 LDCM0372  CL103 HEK-293T C794(1.09); C779(0.99)  LDD1576  [10]
 LDCM0373  CL104 HEK-293T C794(1.06); C779(1.10)  LDD1577  [10]
 LDCM0374  CL105 HEK-293T C794(0.99)  LDD1578  [10]
 LDCM0375  CL106 HEK-293T C794(1.19); C779(0.94)  LDD1579  [10]
 LDCM0376  CL107 HEK-293T C794(1.11); C779(1.01)  LDD1580  [10]
 LDCM0377  CL108 HEK-293T C794(0.91); C779(0.98)  LDD1581  [10]
 LDCM0378  CL109 HEK-293T C794(1.17)  LDD1582  [10]
 LDCM0379  CL11 HEK-293T C794(1.14)  LDD1583  [10]
 LDCM0380  CL110 HEK-293T C794(0.98); C779(1.11)  LDD1584  [10]
 LDCM0381  CL111 HEK-293T C794(0.85); C779(0.94)  LDD1585  [10]
 LDCM0382  CL112 HEK-293T C794(1.05); C779(0.97)  LDD1586  [10]
 LDCM0383  CL113 HEK-293T C794(1.16)  LDD1587  [10]
 LDCM0384  CL114 HEK-293T C794(1.44); C779(0.96)  LDD1588  [10]
 LDCM0385  CL115 HEK-293T C794(0.91); C779(0.91)  LDD1589  [10]
 LDCM0386  CL116 HEK-293T C794(1.09); C779(0.99)  LDD1590  [10]
 LDCM0387  CL117 HEK-293T C794(0.98)  LDD1591  [10]
 LDCM0388  CL118 HEK-293T C794(1.16); C779(1.09)  LDD1592  [10]
 LDCM0389  CL119 HEK-293T C794(1.05); C779(0.91)  LDD1593  [10]
 LDCM0390  CL12 HEK-293T C794(1.11)  LDD1594  [10]
 LDCM0391  CL120 HEK-293T C794(1.12); C779(1.02)  LDD1595  [10]
 LDCM0392  CL121 HEK-293T C794(0.95)  LDD1596  [10]
 LDCM0393  CL122 HEK-293T C794(1.11); C779(0.99)  LDD1597  [10]
 LDCM0394  CL123 HEK-293T C794(1.21); C779(0.96)  LDD1598  [10]
 LDCM0395  CL124 HEK-293T C794(1.09); C779(1.24)  LDD1599  [10]
 LDCM0396  CL125 HEK-293T C794(0.91)  LDD1600  [10]
 LDCM0397  CL126 HEK-293T C794(1.01); C779(0.97)  LDD1601  [10]
 LDCM0398  CL127 HEK-293T C794(1.04); C779(0.96)  LDD1602  [10]
 LDCM0399  CL128 HEK-293T C794(1.10); C779(1.00)  LDD1603  [10]
 LDCM0400  CL13 HEK-293T C794(1.05)  LDD1604  [10]
 LDCM0401  CL14 HEK-293T C794(0.95); C779(1.25)  LDD1605  [10]
 LDCM0402  CL15 HEK-293T C794(1.04); C779(1.08)  LDD1606  [10]
 LDCM0403  CL16 HEK-293T C794(1.32); C779(1.03)  LDD1607  [10]
 LDCM0404  CL17 HEK-293T C794(1.36)  LDD1608  [10]
 LDCM0405  CL18 HEK-293T C794(1.09)  LDD1609  [10]
 LDCM0406  CL19 HEK-293T C794(1.16)  LDD1610  [10]
 LDCM0407  CL2 HEK-293T C794(1.20); C779(1.22)  LDD1611  [10]
 LDCM0408  CL20 HEK-293T C794(1.12)  LDD1612  [10]
 LDCM0409  CL21 HEK-293T C794(1.16)  LDD1613  [10]
 LDCM0410  CL22 HEK-293T C794(1.07)  LDD1614  [10]
 LDCM0411  CL23 HEK-293T C794(1.01)  LDD1615  [10]
 LDCM0412  CL24 HEK-293T C794(0.98)  LDD1616  [10]
 LDCM0413  CL25 HEK-293T C794(1.31)  LDD1617  [10]
 LDCM0414  CL26 HEK-293T C794(1.05); C779(1.08)  LDD1618  [10]
 LDCM0415  CL27 HEK-293T C794(1.00); C779(0.99)  LDD1619  [10]
 LDCM0416  CL28 HEK-293T C794(1.12); C779(1.00)  LDD1620  [10]
 LDCM0417  CL29 HEK-293T C794(1.39)  LDD1621  [10]
 LDCM0418  CL3 HEK-293T C794(1.13); C779(1.07)  LDD1622  [10]
 LDCM0419  CL30 HEK-293T C794(0.95)  LDD1623  [10]
 LDCM0420  CL31 HEK-293T C794(1.03)  LDD1624  [10]
 LDCM0421  CL32 HEK-293T C794(1.27)  LDD1625  [10]
 LDCM0422  CL33 HEK-293T C794(1.18)  LDD1626  [10]
 LDCM0423  CL34 HEK-293T C794(1.09)  LDD1627  [10]
 LDCM0424  CL35 HEK-293T C794(1.04)  LDD1628  [10]
 LDCM0425  CL36 HEK-293T C794(1.14)  LDD1629  [10]
 LDCM0426  CL37 HEK-293T C794(1.35)  LDD1630  [10]
 LDCM0428  CL39 HEK-293T C794(1.19); C779(0.96)  LDD1632  [10]
 LDCM0429  CL4 HEK-293T C794(1.41); C779(1.02)  LDD1633  [10]
 LDCM0430  CL40 HEK-293T C794(1.08); C779(1.03)  LDD1634  [10]
 LDCM0431  CL41 HEK-293T C794(1.20)  LDD1635  [10]
 LDCM0432  CL42 HEK-293T C794(1.13)  LDD1636  [10]
 LDCM0433  CL43 HEK-293T C794(1.18)  LDD1637  [10]
 LDCM0434  CL44 HEK-293T C794(1.16)  LDD1638  [10]
 LDCM0435  CL45 HEK-293T C794(1.10)  LDD1639  [10]
 LDCM0436  CL46 HEK-293T C794(1.06)  LDD1640  [10]
 LDCM0437  CL47 HEK-293T C794(1.16)  LDD1641  [10]
 LDCM0438  CL48 HEK-293T C794(0.95)  LDD1642  [10]
 LDCM0439  CL49 HEK-293T C794(1.07)  LDD1643  [10]
 LDCM0440  CL5 HEK-293T C794(1.17)  LDD1644  [10]
 LDCM0441  CL50 HEK-293T C794(1.38); C779(1.05)  LDD1645  [10]
 LDCM0443  CL52 HEK-293T C794(1.48); C779(1.02)  LDD1646  [10]
 LDCM0444  CL53 HEK-293T C794(1.24)  LDD1647  [10]
 LDCM0445  CL54 HEK-293T C794(1.23)  LDD1648  [10]
 LDCM0446  CL55 HEK-293T C794(1.34)  LDD1649  [10]
 LDCM0447  CL56 HEK-293T C794(1.08)  LDD1650  [10]
 LDCM0448  CL57 HEK-293T C794(1.16)  LDD1651  [10]
 LDCM0449  CL58 HEK-293T C794(1.31)  LDD1652  [10]
 LDCM0450  CL59 HEK-293T C794(1.07)  LDD1653  [10]
 LDCM0451  CL6 HEK-293T C794(1.12)  LDD1654  [10]
 LDCM0452  CL60 HEK-293T C794(1.03)  LDD1655  [10]
 LDCM0453  CL61 HEK-293T C794(1.25)  LDD1656  [10]
 LDCM0454  CL62 HEK-293T C794(1.08); C779(0.92)  LDD1657  [10]
 LDCM0455  CL63 HEK-293T C794(0.87); C779(1.08)  LDD1658  [10]
 LDCM0456  CL64 HEK-293T C794(1.25); C779(1.07)  LDD1659  [10]
 LDCM0457  CL65 HEK-293T C794(1.06)  LDD1660  [10]
 LDCM0458  CL66 HEK-293T C794(1.22)  LDD1661  [10]
 LDCM0459  CL67 HEK-293T C794(1.12)  LDD1662  [10]
 LDCM0460  CL68 HEK-293T C794(1.37)  LDD1663  [10]
 LDCM0461  CL69 HEK-293T C794(1.10)  LDD1664  [10]
 LDCM0462  CL7 HEK-293T C794(1.26)  LDD1665  [10]
 LDCM0463  CL70 HEK-293T C794(1.31)  LDD1666  [10]
 LDCM0464  CL71 HEK-293T C794(1.04)  LDD1667  [10]
 LDCM0465  CL72 HEK-293T C794(0.97)  LDD1668  [10]
 LDCM0466  CL73 HEK-293T C794(1.32)  LDD1669  [10]
 LDCM0467  CL74 HEK-293T C794(0.99); C779(1.00)  LDD1670  [10]
 LDCM0469  CL76 HEK-293T C794(1.13); C779(0.97)  LDD1672  [10]
 LDCM0470  CL77 HEK-293T C794(1.38)  LDD1673  [10]
 LDCM0471  CL78 HEK-293T C794(0.97)  LDD1674  [10]
 LDCM0472  CL79 HEK-293T C794(1.38)  LDD1675  [10]
 LDCM0473  CL8 HEK-293T C794(1.53)  LDD1676  [10]
 LDCM0474  CL80 HEK-293T C794(1.19)  LDD1677  [10]
 LDCM0475  CL81 HEK-293T C794(0.96)  LDD1678  [10]
 LDCM0476  CL82 HEK-293T C794(1.09)  LDD1679  [10]
 LDCM0477  CL83 HEK-293T C794(1.13)  LDD1680  [10]
 LDCM0478  CL84 HEK-293T C794(1.14)  LDD1681  [10]
 LDCM0479  CL85 HEK-293T C794(1.01)  LDD1682  [10]
 LDCM0480  CL86 HEK-293T C794(1.09); C779(1.16)  LDD1683  [10]
 LDCM0481  CL87 HEK-293T C794(1.04); C779(1.04)  LDD1684  [10]
 LDCM0482  CL88 HEK-293T C794(1.11); C779(1.07)  LDD1685  [10]
 LDCM0483  CL89 HEK-293T C794(0.97)  LDD1686  [10]
 LDCM0484  CL9 HEK-293T C794(1.25)  LDD1687  [10]
 LDCM0485  CL90 HEK-293T C794(1.37)  LDD1688  [10]
 LDCM0486  CL91 HEK-293T C794(1.45)  LDD1689  [10]
 LDCM0487  CL92 HEK-293T C794(1.46)  LDD1690  [10]
 LDCM0488  CL93 HEK-293T C794(1.14)  LDD1691  [10]
 LDCM0489  CL94 HEK-293T C794(1.20)  LDD1692  [10]
 LDCM0490  CL95 HEK-293T C794(1.01)  LDD1693  [10]
 LDCM0491  CL96 HEK-293T C794(1.02)  LDD1694  [10]
 LDCM0492  CL97 HEK-293T C794(1.30)  LDD1695  [10]
 LDCM0493  CL98 HEK-293T C794(1.06); C779(1.08)  LDD1696  [10]
 LDCM0494  CL99 HEK-293T C794(0.94); C779(0.89)  LDD1697  [10]
 LDCM0495  E2913 HEK-293T C794(1.03); C779(0.95)  LDD1698  [10]
 LDCM0468  Fragment33 HEK-293T C794(1.08); C779(0.83)  LDD1671  [10]
 LDCM0427  Fragment51 HEK-293T C794(1.13); C779(1.07)  LDD1631  [10]
 LDCM0022  KB02 FU-OV-1 C779(1.66)  LDD2328  [2]
 LDCM0023  KB03 FU-OV-1 C779(2.58)  LDD2745  [2]
 LDCM0024  KB05 COLO792 C779(2.47)  LDD3310  [2]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C794(0.81)  LDD2105  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Disabled homolog 1 (DAB1) . O75553

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
8 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
9 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402