Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C194  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 95 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP14218  Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) 56.1
 LDTP08512  Malonyl-CoA-acyl carrier protein transacylase, mitochondrial (MCAT) 54.9
 LDTP03787  Choline kinase alpha (CHKA) 49.5
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 32.0
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 31.8
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 31.1
 LDTP01769  Dihydrofolate reductase (DHFR) 30.9
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 30.1
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 28.6
 LDTP08728  Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) 28.6
 LDTP05029  Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A) 27.3
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 26.2
 LDTP00486  Cytochrome b-c1 complex subunit 8 (UQCRQ) 25.3
 LDTP02505  Lysosomal protective protein (CTSA) 24.1
 LDTP06617  Ceramide glucosyltransferase (UGCG) 23.9
 LDTP16007  Lipid droplet-associated hydrolase (LDAH) 23.3
 LDTP06200  Delta(14)-sterol reductase LBR (LBR) 23.1
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 22.2
 LDTP10329  Ceramide synthase 2 (CERS2) 21.6
 LDTP03540  Heme oxygenase 2 (HMOX2) 20.4
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 20.3
 LDTP02549  Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (PDHB) 19.3
 LDTP00697  Cytochrome b5 type B (CYB5B) 19.2
 LDTP02005  Lysosomal acid glucosylceramidase (GBA1) 18.8
 LDTP10032  7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) 18.6
 LDTP05066  Signal peptidase complex catalytic subunit SEC11A (SEC11A) 18.4
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 18.3
 LDTP03842  Squalene synthase (FDFT1) 18.3
 LDTP12720  Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) 17.8
 LDTP05905  Acid ceramidase (ASAH1) 17.4
 LDTP09256  Putative phospholipase B-like 2 (PLBD2) 17.1
 LDTP05476  3-ketodihydrosphingosine reductase (KDSR) 17.0
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 16.8
 LDTP03662  Long-chain-fatty-acid--CoA ligase 1 (ACSL1) 16.7
 LDTP02837  Beta-galactosidase (GLB1) 16.3
 LDTP02359  Heme oxygenase 1 (HMOX1) 15.8
 LDTP17410  Cytochrome P450 20A1 (CYP20A1) 15.0
 LDTP07868  Protein O-mannosyl-transferase TMTC3 (TMTC3) 14.8
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 14.6
 LDTP09043  Lysine-specific histone demethylase 2 (KDM1B) 14.6
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 13.9
 LDTP10887  Synaptic vesicle membrane protein VAT-1 homolog (VAT1) 13.8
 LDTP02223  Cathepsin B (CTSB) 13.5
 LDTP04437  Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) 13.5
 LDTP10188  FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1) 13.4
 LDTP11273  N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) 13.4
 LDTP12868  Endoplasmic reticulum aminopeptidase 1 (ERAP1) 13.3
 LDTP11127  ADP-dependent glucokinase (ADPGK) 12.9
 LDTP04634  Alpha-N-acetylglucosaminidase (NAGLU) 12.6
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 12.6
 LDTP05346  Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial (ALDH6A1) 12.6
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 12.5
 LDTP08017  Endoplasmic reticulum metallopeptidase 1 (ERMP1) 12.2
 LDTP08790  Mitochondrial cardiolipin hydrolase (PLD6) 12.2
 LDTP09395  Signal peptide peptidase-like 2A (SPPL2A) 12.0
 LDTP06901  Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) 11.6
 LDTP04333  GMP synthase [glutamine-hydrolyzing] (GMPS) 11.5
 LDTP05344  Kinesin-like protein KIF23 (KIF23) 11.4
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 11.4
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 11.3
 LDTP03418  Proteasome subunit beta type-6 (PSMB6) 11.2
 LDTP00988  Protein O-GlcNAcase (OGA) 11.0
 LDTP00717  Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 (PAPSS1) 10.9
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 10.8
 LDTP06618  ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) 10.5
 LDTP02640  X-ray repair cross-complementing protein 6 (XRCC6) 10.5
 LDTP10888  Legumain (LGMN) 10.4
 LDTP11081  NAD-capped RNA hydrolase NUDT12 (NUDT12) 10.0
 LDTP07831  Transmembrane protein with metallophosphoesterase domain (TMPPE) 10.0
 LDTP02169  Beta-hexosaminidase subunit alpha (HEXA) 9.9
 LDTP06787  Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) 9.9
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 9.8
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) 9.8
 LDTP09088  Phospholipase A2 group XV (PLA2G15) 9.7
 LDTP02141  Alpha-galactosidase A (GLA) 9.6
 LDTP02848  NADPH--cytochrome P450 reductase (POR) 9.6
 LDTP05372  Peptidyl-prolyl cis-trans isomerase FKBP4 (FKBP4) 9.6
 LDTP01462  Endonuclease domain-containing 1 protein (ENDOD1) 9.4
 LDTP02539  Lysosomal acid phosphatase (ACP2) 9.4
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 9.4
 LDTP11225  Deoxyhypusine hydroxylase (DOHH) 9.3
 LDTP00428  Tripeptidyl-peptidase 1 (TPP1) 9.2
 LDTP03145  Catechol O-methyltransferase (COMT) 9.1
 LDTP03523  Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PPP2R1B) 9.1
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 9.0
 LDTP10612  Lysophospholipid acyltransferase 7 (MBOAT7) 9.0
 LDTP13814  Phospholipase A-2-activating protein (PLAA) 9.0
 LDTP13986  Vesicle transport protein GOT1B (GOLT1B) 9.0
 LDTP03854  Vitamin K-dependent gamma-carboxylase (GGCX) 8.9
 LDTP01513  NADH dehydrogenase 1 alpha subcomplex subunit 3 (NDUFA3) 8.8
 LDTP14141  Mannose-1-phosphate guanyltransferase beta (GMPPB) 8.8
 LDTP09799  DCN1-like protein 4 (DCUN1D4) 8.7
 LDTP13131  7-dehydrocholesterol reductase (DHCR7) 8.5
 LDTP06849  Prolyl endopeptidase-like (PREPL) 8.5
 LDTP02254  ATP-dependent translocase ABCB1 (ABCB1) 8.5
Transporter and channel
Click to Show/Hide to Show 69 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 69.6
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 36.8
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 32.9
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 27.7
 LDTP15948  Transmembrane protein 126A (TMEM126A) 27.3
 LDTP05900  Metaxin-1 (MTX1) 26.5
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 25.1
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 24.9
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 24.4
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 23.8
 LDTP16813  Tetraspanin-3 (TSPAN3) 23.1
 LDTP05116  CMP-sialic acid transporter (SLC35A1) 22.9
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 22.8
 LDTP08881  Transmembrane protein 199 (TMEM199) 22.6
 LDTP02215  Prosaposin (PSAP) 22.3
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 21.7
 LDTP20002  Transmembrane protein 160 (TMEM160) 21.3
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 21.1
 LDTP11615  Protein tweety homolog 3 (TTYH3) 21.1
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 20.8
 LDTP01804  ATP synthase subunit a (MT-ATP6) 19.0
 LDTP16069  Peroxisomal membrane protein 2 (PXMP2) 18.6
 LDTP12383  Protein GPR108 (GPR108) 18.4
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 18.0
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 18.0
 LDTP05662  Cell division cycle protein 20 homolog (CDC20) 16.6
 LDTP11812  Protein ARV1 (ARV1) 16.0
 LDTP14140  Ceramide transfer protein (CERT1) 15.8
 LDTP18459  StAR-related lipid transfer protein 7, mitochondrial (STARD7) 15.7
 LDTP07236  Protein GPR107 (GPR107) 14.9
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 14.7
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 14.7
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 14.6
 LDTP08878  ER membrane protein complex subunit 5 (MMGT1) 14.0
 LDTP03380  Stomatin (STOM) 13.8
 LDTP06308  Mitochondrial inner membrane protein OXA1L (OXA1L) 13.5
 LDTP16190  Protein FAM8A1 (FAM8A1) 13.5
 LDTP01745  Putative lipid scramblase CLPTM1 (CLPTM1) 13.5
 LDTP00477  Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23) 12.9
 LDTP09328  Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) 12.6
 LDTP10065  Transmembrane protein 230 (TMEM230) 12.5
 LDTP02010  Annexin A1 (ANXA1) 12.4
 LDTP00541  NPC intracellular cholesterol transporter 1 (NPC1) 12.3
 LDTP10669  Melanoma inhibitory activity protein 2 (MIA2) 12.1
 LDTP17362  Magnesium transporter NIPA3 (NIPAL1) 12.0
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 11.9
 LDTP10036  BOS complex subunit NCLN (NCLN) 11.8
 LDTP00547  Secretory carrier-associated membrane protein 2 (SCAMP2) 11.3
 LDTP15733  Solute carrier family 25 member 44 (SLC25A44) 11.3
 LDTP01060  PRA1 family protein 2 (PRAF2) 10.9
 LDTP11869  Growth hormone-inducible transmembrane protein (GHITM) 10.6
 LDTP10499  Lipid scramblase CLPTM1L (CLPTM1L) 10.5
 LDTP11250  MICOS complex subunit MIC26 (APOO) 10.4
 LDTP13983  Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) 10.1
 LDTP02071  Amyloid-beta precursor protein (APP) 10.1
 LDTP11245  Derlin-1 (DERL1) 10.1
 LDTP01200  Peroxisomal membrane protein PEX14 (PEX14) 10.0
 LDTP10059  PAT complex subunit CCDC47 (CCDC47) 9.9
 LDTP09294  Proton-coupled zinc antiporter SLC30A5 (SLC30A5) 9.8
 LDTP02256  Amino acid transporter heavy chain SLC3A2 (SLC3A2) 9.7
 LDTP11213  Nucleoporin NDC1 (NDC1) 9.3
 LDTP12451  Integral membrane protein 2C (ITM2C) 9.2
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) 8.9
 LDTP05511  Cytoskeleton-associated protein 4 (CKAP4) 8.9
 LDTP07531  Sideroflexin-4 (SFXN4) 8.9
 LDTP14200  Mitochondrial ornithine transporter 1 (SLC25A15) 8.8
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 8.5
 LDTP01525  Mitochondrial proton/calcium exchanger protein (LETM1) 8.5
 LDTP15000  Solute carrier family 35 member F1 (SLC35F1) 8.5
Immunoglobulin
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03772  Basigin (BSG) 8.5
Other
Click to Show/Hide to Show 56 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP11076  Apolipoprotein L2 (APOL2) 68.6
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 46.5
 LDTP08796  Protein SYS1 homolog (SYS1) 44.9
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 44.9
 LDTP05160  Nucleobindin-2 (NUCB2) 41.6
 LDTP13606  Mammalian ependymin-related protein 1 (EPDR1) 32.4
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 32.0
 LDTP07476  RAD50-interacting protein 1 (RINT1) 30.3
 LDTP14458  Tetraspanin-6 (TSPAN6) 26.7
 LDTP17640  RNA-binding protein 12B (RBM12B) 25.6
 LDTP03926  Centrin-2 (CETN2) 23.6
 LDTP13086  Syntaxin-18 (STX18) 19.2
 LDTP05375  Nucleobindin-1 (NUCB1) 18.5
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 18.3
 LDTP01522  Reticulon-3 (RTN3) 17.5
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 16.3
 LDTP00105  Protein unc-119 homolog B (UNC119B) 16.2
 LDTP03352  Splicing factor U2AF 65 kDa subunit (U2AF2) 16.1
 LDTP13311  Poly(U)-binding-splicing factor PUF60 (PUF60) 15.3
 LDTP19963  TraB domain-containing protein (TRABD) 15.0
 LDTP00871  Microtubule nucleation factor SSNA1 (SSNA1) 14.4
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 13.9
 LDTP16323  Signal recognition particle receptor subunit beta (SRPRB) 13.9
 LDTP06291  ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL6IP1) 13.5
 LDTP12642  CYFIP-related Rac1 interactor B (CYRIB) 13.3
 LDTP13630  Neudesin (NENF) 13.0
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 12.6
 LDTP16285  Transducin beta-like protein 2 (TBL2) 12.6
 LDTP16099  p53 and DNA damage-regulated protein 1 (PDRG1) 12.5
 LDTP19780  Keratinocyte-associated transmembrane protein 2 (KCT2) 12.3
 LDTP10056  Protein FAM162A (FAM162A) 12.2
 LDTP06097  Reticulocalbin-2 (RCN2) 12.0
 LDTP02443  Calmodulin-3 (CALM3) 11.4
 LDTP04652  Eukaryotic translation initiation factor 5 (EIF5) 11.2
 LDTP16080  Protein FAM114A2 (FAM114A2) 11.2
 LDTP00859  Synaptogyrin-2 (SYNGR2) 11.1
 LDTP07368  Tetratricopeptide repeat protein 19, mitochondrial (TTC19) 10.7
 LDTP17652  Uncharacterized protein KIAA2013 (KIAA2013) 10.6
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 10.5
 LDTP08594  Negative elongation factor C/D (NELFCD) 10.4
 LDTP18373  Thioredoxin-related transmembrane protein 4 (TMX4) 10.3
 LDTP16006  Optic atrophy 3 protein (OPA3) 10.3
 LDTP05734  Protein flightless-1 homolog (FLII) 9.8
 LDTP07274  MICOS complex subunit MIC13 (MICOS13) 9.6
 LDTP17266  Pre-mRNA-splicing factor 38B (PRPF38B) 9.6
 LDTP04684  Nucleosome assembly protein 1-like 1 (NAP1L1) 9.4
 LDTP01163  Ubiquinone biosynthesis protein COQ9, mitochondrial (COQ9) 9.3
 LDTP06413  Microtubule-associated protein RP/EB family member 2 (MAPRE2) 9.3
 LDTP06121  Caprin-1 (CAPRIN1) 9.2
 LDTP09787  Nicastrin (NCSTN) 9.2
 LDTP01359  Dynactin subunit 3 (DCTN3) 9.0
 LDTP16322  Mitochondrial import inner membrane translocase subunit Tim8 B (TIMM8B) 8.9
 LDTP12623  Zinc finger CCHC domain-containing protein 3 (ZCCHC3) 8.8
 LDTP09215  Torsin-1A-interacting protein 2 (TOR1AIP2) 8.6
 LDTP15834  Integrator complex subunit 14 (INTS14) 8.5
 LDTP10965  Nucleosome assembly protein 1-like 4 (NAP1L4) 8.5

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587