General Information of Target

Target ID LDTP03926
Target Name Centrin-2 (CETN2)
Gene Name CETN2
Gene ID 1069
Synonyms
CALT; CEN2; Centrin-2; Caltractin isoform 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASNFKKANMASSSQRKRMSPKPELTEEQKQEIREAFDLFDADGTGTIDVKELKVAMRAL
GFEPKKEEIKKMISEIDKEGTGKMNFGDFLTVMTQKMSEKDTKEEILKAFKLFDDDETGK
ISFKNLKRVAKELGENLTDEELQEMIDEADRDGDGEVSEQEFLRIMKKTSLY
Target Bioclass
Other
Family
Centrin family
Subcellular location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Function
Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110.; Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with RAD23B appears to stabilize XPC. In vitro, stimulates DNA binding of the XPC:RAD23B dimer.; The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair.; As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores.
Uniprot ID
P41208
Ensemble ID
ENST00000370277.5
HGNC ID
HGNC:1867

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C-Sul
 Probe Info 
11.10  LDD0066  [1]
PAL-AfBPP Probe
Click To Hide/Show 61 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C003
 Probe Info 
16.22  LDD1713  [2]
C007
 Probe Info 
6.19  LDD1716  [2]
C040
 Probe Info 
34.78  LDD1740  [2]
C041
 Probe Info 
8.00  LDD1741  [2]
C049
 Probe Info 
5.35  LDD1747  [2]
C053
 Probe Info 
15.67  LDD1751  [2]
C055
 Probe Info 
20.97  LDD1752  [2]
C056
 Probe Info 
86.22  LDD1753  [2]
C063
 Probe Info 
36.76  LDD1760  [2]
C067
 Probe Info 
9.71  LDD1763  [2]
C070
 Probe Info 
12.82  LDD1766  [2]
C087
 Probe Info 
8.06  LDD1779  [2]
C095
 Probe Info 
56.49  LDD1786  [2]
C106
 Probe Info 
42.52  LDD1793  [2]
C107
 Probe Info 
5.70  LDD1794  [2]
C108
 Probe Info 
7.89  LDD1795  [2]
C112
 Probe Info 
43.71  LDD1799  [2]
C143
 Probe Info 
19.16  LDD1825  [2]
C158
 Probe Info 
10.06  LDD1838  [2]
C159
 Probe Info 
7.52  LDD1839  [2]
C160
 Probe Info 
7.11  LDD1840  [2]
C161
 Probe Info 
15.35  LDD1841  [2]
C169
 Probe Info 
30.27  LDD1849  [2]
C178
 Probe Info 
39.95  LDD1857  [2]
C183
 Probe Info 
5.39  LDD1861  [2]
C194
 Probe Info 
23.59  LDD1870  [2]
C196
 Probe Info 
24.25  LDD1872  [2]
C201
 Probe Info 
39.67  LDD1877  [2]
C206
 Probe Info 
19.29  LDD1881  [2]
C210
 Probe Info 
50.91  LDD1884  [2]
C219
 Probe Info 
5.86  LDD1893  [2]
C226
 Probe Info 
6.92  LDD1899  [2]
C228
 Probe Info 
20.97  LDD1901  [2]
C231
 Probe Info 
32.22  LDD1904  [2]
C238
 Probe Info 
14.52  LDD1911  [2]
C243
 Probe Info 
15.24  LDD1916  [2]
C246
 Probe Info 
13.18  LDD1919  [2]
C264
 Probe Info 
17.15  LDD1935  [2]
C284
 Probe Info 
20.82  LDD1954  [2]
C285
 Probe Info 
22.01  LDD1955  [2]
C289
 Probe Info 
26.35  LDD1959  [2]
C293
 Probe Info 
57.68  LDD1963  [2]
C296
 Probe Info 
13.27  LDD1966  [2]
C305
 Probe Info 
38.32  LDD1974  [2]
C310
 Probe Info 
18.51  LDD1977  [2]
C313
 Probe Info 
15.67  LDD1980  [2]
C314
 Probe Info 
14.83  LDD1981  [2]
C343
 Probe Info 
11.88  LDD2005  [2]
C355
 Probe Info 
38.85  LDD2016  [2]
C356
 Probe Info 
9.13  LDD2017  [2]
C362
 Probe Info 
53.82  LDD2023  [2]
C363
 Probe Info 
17.75  LDD2024  [2]
C364
 Probe Info 
29.04  LDD2025  [2]
C376
 Probe Info 
7.06  LDD2036  [2]
C383
 Probe Info 
13.45  LDD2042  [2]
C388
 Probe Info 
99.73  LDD2047  [2]
C390
 Probe Info 
24.59  LDD2049  [2]
C399
 Probe Info 
7.89  LDD2058  [2]
C413
 Probe Info 
12.73  LDD2069  [2]
C429
 Probe Info 
11.55  LDD2084  [2]
C431
 Probe Info 
20.39  LDD2086  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ubiquitin carboxyl-terminal hydrolase 44 (USP44) Peptidase C19 family Q9H0E7
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Paraneoplastic antigen-like protein 5 (PNMA5) PNMA family Q96PV4
Centrosomal protein POC5 (POC5) POC5 family Q8NA72
Protein SFI1 homolog (SFI1) SFI1 family A8K8P3
DNA repair protein complementing XP-C cells (XPC) XPC family Q01831
Centriolar coiled-coil protein of 110 kDa (CCP110) . O43303

References

1 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
2 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587