Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C040  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 190 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02359  Heme oxygenase 1 (HMOX1) 66.7
 LDTP01743  NADH dehydrogenase 1 beta subcomplex subunit 10 (NDUFB10) 54.6
 LDTP03540  Heme oxygenase 2 (HMOX2) 54.2
 LDTP05066  Signal peptidase complex catalytic subunit SEC11A (SEC11A) 51.3
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 48.5
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 45.6
 LDTP00486  Cytochrome b-c1 complex subunit 8 (UQCRQ) 41.6
 LDTP04689  Adenosine kinase (ADK) 41.4
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 41.4
 LDTP06325  3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) 38.1
 LDTP00697  Cytochrome b5 type B (CYB5B) 36.0
 LDTP09096  Carbohydrate sulfotransferase 14 (CHST14) 33.4
 LDTP12867  Very-long-chain enoyl-CoA reductase (TECR) 32.7
 LDTP04437  Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) 31.1
 LDTP10329  Ceramide synthase 2 (CERS2) 30.9
 LDTP12959  NADH dehydrogenase 1 alpha subcomplex subunit 13 (NDUFA13) 30.7
 LDTP17410  Cytochrome P450 20A1 (CYP20A1) 29.2
 LDTP14276  NADH dehydrogenase 1 beta subcomplex subunit 9 (NDUFB9) 29.0
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 27.1
 LDTP03394  Ceramide synthase 1 (CERS1) 26.9
 LDTP07990  Heparan sulfate 2-O-sulfotransferase 1 (HS2ST1) 26.2
 LDTP04506  Diacylglycerol kinase epsilon (DGKE) 23.6
 LDTP11259  Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase (ALG12) 23.3
 LDTP06787  Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) 22.8
 LDTP10550  Dehydrogenase/reductase SDR family member 1 (DHRS1) 22.0
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 21.9
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 21.1
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 20.8
 LDTP09620  Soluble calcium-activated nucleotidase 1 (CANT1) 20.4
 LDTP12873  CDGSH iron-sulfur domain-containing protein 1 (CISD1) 20.0
 LDTP11127  ADP-dependent glucokinase (ADPGK) 19.6
 LDTP06142  Squalene monooxygenase (SQLE) 19.4
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 19.2
 LDTP14030  V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) 19.2
 LDTP10930  Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (PKMYT1) 19.0
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 18.5
 LDTP16007  Lipid droplet-associated hydrolase (LDAH) 18.3
 LDTP11494  Neurolysin, mitochondrial (NLN) 17.8
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 17.5
 LDTP01462  Endonuclease domain-containing 1 protein (ENDOD1) 17.1
 LDTP15422  Prostaglandin reductase 3 (PTGR3) 16.8
 LDTP10038  Mitochondrial ubiquitin ligase activator of NFKB 1 (MUL1) 16.7
 LDTP03854  Vitamin K-dependent gamma-carboxylase (GGCX) 16.7
 LDTP01773  Cytochrome c oxidase subunit 2 (MT-CO2) 16.6
 LDTP05588  RNA cytosine C(5)-methyltransferase NSUN2 (NSUN2) 16.6
 LDTP08979  Prostaglandin reductase 2 (PTGR2) 16.3
 LDTP15328  Dolichyldiphosphatase 1 (DOLPP1) 15.9
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 15.6
 LDTP06750  Prolyl 3-hydroxylase 1 (P3H1) 15.5
 LDTP12040  Prostaglandin E synthase 2 (PTGES2) 15.5
 LDTP03842  Squalene synthase (FDFT1) 15.5
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 15.1
 LDTP01613  Sphingosine-1-phosphate lyase 1 (SGPL1) 15.1
 LDTP12415  Adenosine 5'-monophosphoramidase HINT3 (HINT3) 15.0
 LDTP02860  Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) 14.9
 LDTP13620  Lysosomal thioesterase PPT2 (PPT2) 14.5
 LDTP00344  Stearoyl-CoA desaturase (SCD) 14.2
 LDTP13486  Long-chain-fatty-acid--CoA ligase 6 (ACSL6) 14.1
 LDTP07831  Transmembrane protein with metallophosphoesterase domain (TMPPE) 14.1
 LDTP03145  Catechol O-methyltransferase (COMT) 14.0
 LDTP01687  Apoptosis-inducing factor 1, mitochondrial (AIFM1) 13.9
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 13.9
 LDTP12628  Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) 13.7
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 13.6
 LDTP06477  Methylsterol monooxygenase 1 (MSMO1) 13.6
 LDTP01982  NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) 13.5
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 13.5
 LDTP06501  Ras-related protein Rab-11B (RAB11B) 13.5
 LDTP09666  Reticulon-4-interacting protein 1, mitochondrial (RTN4IP1) 13.5
 LDTP05905  Acid ceramidase (ASAH1) 13.5
 LDTP10020  Ras-related protein Rab-24 (RAB24) 13.4
 LDTP09095  Diacylglycerol lipase-beta (DAGLB) 13.3
 LDTP08728  Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) 13.1
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 12.7
 LDTP06200  Delta(14)-sterol reductase LBR (LBR) 12.5
 LDTP14218  Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) 12.2
 LDTP14231  GTP-binding protein SAR1b (SAR1B) 12.1
 LDTP06986  Rab-like protein 3 (RABL3) 12.0
 LDTP09061  Retinol dehydrogenase 13 (RDH13) 12.0
 LDTP05476  3-ketodihydrosphingosine reductase (KDSR) 11.9
 LDTP04120  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (STT3A) 11.8
 LDTP12470  GTP-binding protein SAR1a (SAR1A) 11.8
 LDTP04203  Phosphatidylserine synthase 1 (PTDSS1) 11.8
 LDTP18087  Dephospho-CoA kinase domain-containing protein (DCAKD) 11.5
 LDTP12954  Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 (HACD3) 11.5
 LDTP07529  SCY1-like protein 2 (SCYL2) 11.2
 LDTP11874  Thioredoxin-related transmembrane protein 1 (TMX1) 11.2
 LDTP09188  Lysophosphatidylcholine acyltransferase 1 (LPCAT1) 11.1
 LDTP08859  Polypeptide N-acetylgalactosaminyltransferase 4 (GALNT4) 11.1
 LDTP11178  Chitobiosyldiphosphodolichol beta-mannosyltransferase (ALG1) 11.0
 LDTP01329  Lathosterol oxidase (SC5D) 10.9
 LDTP13466  Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (MAN1B1) 10.9
 LDTP08385  NADH dehydrogenase 1 alpha subcomplex subunit 11 (NDUFA11) 10.7
 LDTP13204  Gamma-adducin (ADD3) 10.4
 LDTP06270  Signal peptidase complex subunit 2 (SPCS2) 10.3
 LDTP09396  Minor histocompatibility antigen H13 (HM13) 10.3
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 10.2
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 10.2
 LDTP00428  Tripeptidyl-peptidase 1 (TPP1) 10.2
 LDTP00950  Dynamin-like 120 kDa protein, mitochondrial (OPA1) 10.1
 LDTP06901  Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) 10.1
 LDTP02837  Beta-galactosidase (GLB1) 10.1
 LDTP12681  ATPase family AAA domain-containing protein 3A (ATAD3A) 10.0
 LDTP11852  Presenilin-associated rhomboid-like protein, mitochondrial (PARL) 10.0
 LDTP09251  Atlastin-2 (ATL2) 9.9
 LDTP05624  Polypeptide N-acetylgalactosaminyltransferase 1 (GALNT1) 9.9
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 9.8
 LDTP09814  Acyl-CoA:lysophosphatidylglycerol acyltransferase 1 (LPGAT1) 9.8
 LDTP08790  Mitochondrial cardiolipin hydrolase (PLD6) 9.8
 LDTP15484  Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) 9.8
 LDTP10432  ATP synthase membrane subunit K, mitochondrial (ATP5MK) 9.7
 LDTP07154  ATPase family AAA domain-containing protein 3B (ATAD3B) 9.7
 LDTP05862  NAD(P) transhydrogenase, mitochondrial (NNT) 9.5
 LDTP06618  ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) 9.4
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 9.3
 LDTP12757  E3 ubiquitin-protein ligase MARCHF5 (MARCHF5) 9.3
 LDTP13751  Exonuclease 1 (EXO1) 9.2
 LDTP10471  Protein disulfide-isomerase TMX3 (TMX3) 9.2
 LDTP01515  NADH dehydrogenase 1 beta subcomplex subunit 8, mitochondrial (NDUFB8) 9.1
 LDTP02848  NADPH--cytochrome P450 reductase (POR) 9.0
 LDTP06150  DNA replication licensing factor MCM6 (MCM6) 8.8
 LDTP11284  Phosphatidylserine synthase 2 (PTDSS2) 8.8
 LDTP10785  Ubiquitin carboxyl-terminal hydrolase 28 (USP28) 8.8
 LDTP06227  Prostaglandin reductase 1 (PTGR1) 8.8
 LDTP04471  Ribosomal protein S6 kinase alpha-3 (RPS6KA3) 8.8
 LDTP00783  Beta-1,4-glucuronyltransferase 1 (B4GAT1) 8.7
 LDTP11733  Ras-related protein Rab-1B (RAB1B) 8.7
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 8.7
 LDTP13986  Vesicle transport protein GOT1B (GOLT1B) 8.6
 LDTP07966  COP9 signalosome complex subunit 6 (COPS6) 8.6
 LDTP07402  Dehydrogenase/reductase SDR family member 7B (DHRS7B) 8.5
 LDTP05632  Mitochondrial-processing peptidase subunit alpha (PMPCA) 8.5
 LDTP02067  Sodium/potassium-transporting ATPase subunit alpha-1 (ATP1A1) 8.5
 LDTP03139  Succinate dehydrogenase iron-sulfur subunit, mitochondrial (SDHB) 8.5
 LDTP02539  Lysosomal acid phosphatase (ACP2) 8.3
 LDTP15154  Dehydrogenase/reductase SDR family member 13 (DHRS13) 8.3
 LDTP15370  Pseudouridylate synthase RPUSD2 (RPUSD2) 8.3
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 8.3
 LDTP01649  Phosphatidate cytidylyltransferase 2 (CDS2) 8.2
 LDTP08378  Serine/threonine-protein kinase VRK2 (VRK2) 8.2
 LDTP12639  1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon (AGPAT5) 8.1
 LDTP05228  Calcium-transporting ATPase type 2C member 1 (ATP2C1) 8.1
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 8.1
 LDTP10612  Lysophospholipid acyltransferase 7 (MBOAT7) 8.1
 LDTP12608  Phosphatidylinositol-3-phosphatase SAC1 (SACM1L) 8.1
 LDTP04358  Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A) 8.0
 LDTP13220  Phosphatidylserine decarboxylase proenzyme, mitochondrial (PISD) 8.0
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 7.8
 LDTP08598  NAD-dependent protein deacetylase sirtuin-2 (SIRT2) 7.8
 LDTP07227  Threonylcarbamoyladenosine tRNA methylthiotransferase (CDKAL1) 7.8
 LDTP10032  7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) 7.7
 LDTP09256  Putative phospholipase B-like 2 (PLBD2) 7.7
 LDTP09395  Signal peptide peptidase-like 2A (SPPL2A) 7.7
 LDTP04581  Holocytochrome c-type synthase (HCCS) 7.7
 LDTP11209  Phosphatidylinositol 4-kinase type 2-alpha (PI4K2A) 7.6
 LDTP07813  Sulfhydryl oxidase 2 (QSOX2) 7.6
 LDTP06905  Acylglycerol kinase, mitochondrial (AGK) 7.6
 LDTP02679  Prolyl 4-hydroxylase subunit alpha-1 (P4HA1) 7.6
 LDTP04892  Ras-related protein Rab-2A (RAB2A) 7.5
 LDTP06455  Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (NSDHL) 7.5
 LDTP12868  Endoplasmic reticulum aminopeptidase 1 (ERAP1) 7.4
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 7.4
 LDTP02150  ATP synthase subunit beta, mitochondrial (ATP5F1B) 7.3
 LDTP04531  Hexokinase-2 (HK2) 7.3
 LDTP02254  ATP-dependent translocase ABCB1 (ABCB1) 7.2
 LDTP06384  Ribosomal protein S6 kinase alpha-1 (RPS6KA1) 7.2
 LDTP08530  Mitofusin-1 (MFN1) 7.1
 LDTP03769  Sterol O-acyltransferase 1 (SOAT1) 7.1
 LDTP04247  Protein farnesyltransferase subunit beta (FNTB) 7.0
 LDTP00416  CDP-diacylglycerol--inositol 3-phosphatidyltransferase (CDIPT) 7.0
 LDTP00032  2-hydroxyacyl-CoA lyase 2 (ILVBL) 6.8
 LDTP09063  Estradiol 17-beta-dehydrogenase 11 (HSD17B11) 6.8
 LDTP12253  Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM) 6.8
 LDTP16025  Ketosamine-3-kinase (FN3KRP) 6.8
 LDTP00877  Protein SCO2 homolog, mitochondrial (SCO2) 6.8
 LDTP06721  GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase (ALG11) 6.7
 LDTP01699  Acyl-CoA 6-desaturase (FADS2) 6.7
 LDTP00589  Peroxisomal acyl-coenzyme A oxidase 3 (ACOX3) 6.7
 LDTP01335  Protein SCO1 homolog, mitochondrial (SCO1) 6.6
 LDTP09835  GPI-anchor transamidase (PIGK) 6.5
 LDTP00890  S-adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) 6.5
 LDTP00597  Serine palmitoyltransferase 1 (SPTLC1) 6.5
 LDTP01168  NADH dehydrogenase iron-sulfur protein 2, mitochondrial (NDUFS2) 6.5
 LDTP04895  Ras-related protein Rab-10 (RAB10) 6.5
 LDTP05949  Cullin-4A (CUL4A) 6.5
 LDTP07679  Lysocardiolipin acyltransferase 1 (LCLAT1) 6.5
 LDTP02486  Lysosomal alpha-glucosidase (GAA) 6.5
 LDTP03858  Lysosomal acid lipase/cholesteryl ester hydrolase (LIPA) 6.4
 LDTP01770  NADH-cytochrome b5 reductase 3 (CYB5R3) 6.4
 LDTP02640  X-ray repair cross-complementing protein 6 (XRCC6) 6.4
Transporter and channel
Click to Show/Hide to Show 141 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 99.7
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 99.7
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 63.1
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 61.4
 LDTP13983  Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) 54.9
 LDTP15648  BRI3-binding protein (BRI3BP) 39.9
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 38.6
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 38.6
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 38.3
 LDTP08881  Transmembrane protein 199 (TMEM199) 37.8
 LDTP20002  Transmembrane protein 160 (TMEM160) 35.0
 LDTP14099  Mitochondrial import inner membrane translocase subunit Tim22 (TIMM22) 32.2
 LDTP07236  Protein GPR107 (GPR107) 30.1
 LDTP01542  Golgi SNAP receptor complex member 1 (GOSR1) 29.0
 LDTP02645  Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1) 28.4
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 28.4
 LDTP10065  Transmembrane protein 230 (TMEM230) 26.9
 LDTP06308  Mitochondrial inner membrane protein OXA1L (OXA1L) 26.7
 LDTP15948  Transmembrane protein 126A (TMEM126A) 26.0
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 25.8
 LDTP11245  Derlin-1 (DERL1) 24.8
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 24.6
 LDTP05511  Cytoskeleton-associated protein 4 (CKAP4) 24.4
 LDTP00235  Membrane-associated progesterone receptor component 1 (PGRMC1) 24.1
 LDTP16813  Tetraspanin-3 (TSPAN3) 23.8
 LDTP08878  ER membrane protein complex subunit 5 (MMGT1) 23.4
 LDTP01745  Putative lipid scramblase CLPTM1 (CLPTM1) 22.8
 LDTP12704  Anoctamin-10 (ANO10) 21.9
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 20.8
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 20.8
 LDTP09968  V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) 20.8
 LDTP15481  Transmembrane protein 87A (TMEM87A) 20.7
 LDTP07531  Sideroflexin-4 (SFXN4) 20.5
 LDTP01671  STARD3 N-terminal-like protein (STARD3NL) 20.1
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 19.6
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 18.5
 LDTP03284  ATP synthase F(0) complex subunit B1, mitochondrial (ATP5PB) 18.4
 LDTP14235  Mitochondrial carrier homolog 2 (MTCH2) 17.9
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 17.6
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 17.4
 LDTP09328  Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) 17.3
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 17.1
 LDTP01180  Programmed cell death protein 6 (PDCD6) 17.1
 LDTP11615  Protein tweety homolog 3 (TTYH3) 16.6
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 16.3
 LDTP01060  PRA1 family protein 2 (PRAF2) 16.0
 LDTP17641  Solute carrier family 35 member F2 (SLC35F2) 15.8
 LDTP04789  Synaptojanin-2-binding protein (SYNJ2BP) 15.2
 LDTP10059  PAT complex subunit CCDC47 (CCDC47) 15.1
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) 15.0
 LDTP16190  Protein FAM8A1 (FAM8A1) 14.8
 LDTP12331  Endoplasmic reticulum membrane protein complex subunit 7 (EMC7) 14.7
 LDTP05900  Metaxin-1 (MTX1) 14.6
 LDTP11213  Nucleoporin NDC1 (NDC1) 14.4
 LDTP14717  ATP synthase subunit e, mitochondrial (ATP5ME) 14.1
 LDTP15733  Solute carrier family 25 member 44 (SLC25A44) 13.6
 LDTP10669  Melanoma inhibitory activity protein 2 (MIA2) 13.3
 LDTP12909  Mitochondrial carrier homolog 1 (MTCH1) 13.3
 LDTP04293  Transmembrane emp24 domain-containing protein 10 (TMED10) 13.3
 LDTP06855  Anoctamin-6 (ANO6) 13.0
 LDTP09288  Vang-like protein 1 (VANGL1) 12.9
 LDTP06221  StAR-related lipid transfer protein 3 (STARD3) 12.5
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 12.4
 LDTP01525  Mitochondrial proton/calcium exchanger protein (LETM1) 12.3
 LDTP08469  Complex I assembly factor TMEM126B, mitochondrial (TMEM126B) 12.2
 LDTP07156  Protein wntless homolog (WLS) 12.0
 LDTP11116  45 kDa calcium-binding protein (SDF4) 11.8
 LDTP00477  Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23) 11.8
 LDTP01200  Peroxisomal membrane protein PEX14 (PEX14) 11.7
 LDTP03546  Translocator protein (TSPO) 11.6
 LDTP13164  Protein sel-1 homolog 1 (SEL1L) 11.6
 LDTP11869  Growth hormone-inducible transmembrane protein (GHITM) 11.5
 LDTP11281  Voltage-gated monoatomic cation channel TMEM109 (TMEM109) 11.4
 LDTP12979  Transmembrane protein 14C (TMEM14C) 10.9
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 10.9
 LDTP04501  Importin subunit alpha-1 (KPNA2) 10.7
 LDTP06365  Transmembrane emp24 domain-containing protein 2 (TMED2) 10.7
 LDTP01380  Wolframin (WFS1) 10.6
 LDTP04227  Guided entry of tail-anchored proteins factor CAMLG (CAMLG) 10.6
 LDTP06633  Reticulon-1 (RTN1) 10.4
 LDTP12210  Mitochondrial thiamine pyrophosphate carrier (SLC25A19) 10.3
 LDTP15838  Translocation protein SEC62 (SEC62) 10.3
 LDTP02609  ADP/ATP translocase 3 (SLC25A6) 10.2
 LDTP07667  Transmembrane protein 205 (TMEM205) 10.1
 LDTP03559  High affinity cationic amino acid transporter 1 (SLC7A1) 9.9
 LDTP01631  Mitochondrial pyruvate carrier 2 (MPC2) 9.8
 LDTP11826  Sodium-dependent neutral amino acid transporter B(0)AT2 (SLC6A15) 9.8
 LDTP11732  Magnesium transporter protein 1 (MAGT1) 9.7
 LDTP00590  Protein RER1 (RER1) 9.6
 LDTP00405  Etoposide-induced protein 2.4 homolog (EI24) 9.6
 LDTP10499  Lipid scramblase CLPTM1L (CLPTM1L) 9.5
 LDTP03811  V-type proton ATPase subunit E 1 (ATP6V1E1) 9.5
 LDTP12661  Exocyst complex component 1 (EXOC1) 9.4
 LDTP10081  Leucine-rich repeat-containing protein 59 (LRRC59) 9.4
 LDTP02608  ADP/ATP translocase 1 (SLC25A4) 9.4
 LDTP07439  Mitochondrial adenyl nucleotide antiporter SLC25A25 (SLC25A25) 9.3
 LDTP14084  Sorting and assembly machinery component 50 homolog (SAMM50) 9.3
 LDTP00882  Glucose-6-phosphate exchanger SLC37A4 (SLC37A4) 9.3
 LDTP04787  Transmembrane protein 33 (TMEM33) 9.2
 LDTP13953  Endophilin-B1 (SH3GLB1) 9.1
 LDTP06499  V-type proton ATPase subunit S1 (ATP6AP1) 9.1
 LDTP04426  B-cell receptor-associated protein 31 (BCAP31) 9.1
 LDTP14200  Mitochondrial ornithine transporter 1 (SLC25A15) 9.0
 LDTP01454  SUN domain-containing protein 1 (SUN1) 9.0
 LDTP13599  Calcium load-activated calcium channel (TMCO1) 8.9
 LDTP05780  Syntaxin-5 (STX5) 8.9
 LDTP15744  Transmembrane protein 101 (TMEM101) 8.9
 LDTP13943  Thioredoxin-related transmembrane protein 2 (TMX2) 8.8
 LDTP09333  Golgin subfamily A member 5 (GOLGA5) 8.8
 LDTP07467  Rhomboid domain-containing protein 2 (RHBDD2) 8.8
 LDTP07058  Transmembrane protein 201 (TMEM201) 8.5
 LDTP15845  Transmembrane 9 superfamily member 2 (TM9SF2) 8.4
 LDTP04459  H(+)/Cl(-) exchange transporter 3 (CLCN3) 8.3
 LDTP10621  Sideroflexin-2 (SFXN2) 8.3
 LDTP11250  MICOS complex subunit MIC26 (APOO) 8.1
 LDTP09515  Importin-4 (IPO4) 8.0
 LDTP01366  Flotillin-1 (FLOT1) 7.9
 LDTP00872  Peroxisomal membrane protein PMP34 (SLC25A17) 7.9
 LDTP02071  Amyloid-beta precursor protein (APP) 7.8
 LDTP03905  Peroxisomal biogenesis factor 19 (PEX19) 7.8
 LDTP02087  ADP/ATP translocase 2 (SLC25A5) 7.7
 LDTP04932  Protein transport protein Sec61 subunit alpha isoform 1 (SEC61A1) 7.6
 LDTP06660  MICOS complex subunit MIC60 (IMMT) 7.5
 LDTP13256  SUN domain-containing protein 2 (SUN2) 7.5
 LDTP11406  Transmembrane protein 59 (TMEM59) 7.5
 LDTP03810  ATP synthase subunit gamma, mitochondrial (ATP5F1C) 7.3
 LDTP07472  Mitochondrial adenyl nucleotide antiporter SLC25A24 (SLC25A24) 7.3
 LDTP06581  Occludin (OCLN) 7.2
 LDTP03405  Calnexin (CANX) 7.2
 LDTP03952  Reduced folate transporter (SLC19A1) 7.2
 LDTP00547  Secretory carrier-associated membrane protein 2 (SCAMP2) 7.1
 LDTP13969  Transmembrane emp24 domain-containing protein 7 (TMED7) 6.9
 LDTP07477  Transmembrane protein 214 (TMEM214) 6.9
 LDTP07537  Metal transporter CNNM4 (CNNM4) 6.7
 LDTP14275  Sodium bicarbonate cotransporter 3 (SLC4A7) 6.6
 LDTP02562  Lysosome-associated membrane glycoprotein 1 (LAMP1) 6.5
 LDTP04592  Monocarboxylate transporter 1 (SLC16A1) 6.4
 LDTP01352  PRA1 family protein 3 (ARL6IP5) 6.4
 LDTP00821  Mitochondrial import inner membrane translocase subunit TIM44 (TIMM44) 6.4
 LDTP18459  StAR-related lipid transfer protein 7, mitochondrial (STARD7) 6.4
 LDTP13416  Stomatin-like protein 2, mitochondrial (STOML2) 6.4
Transcription factor
Click to Show/Hide to Show 3 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10501  DnaJ homolog subfamily C member 1 (DNAJC1) 19.0
 LDTP05065  Y-box-binding protein 1 (YBX1) 8.8
 LDTP13305  SAP30-binding protein (SAP30BP) 6.9
Immunoglobulin
Click to Show/Hide to Show 3 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03772  Basigin (BSG) 9.7
 LDTP05572  Leukocyte surface antigen CD47 (CD47) 7.2
 LDTP14205  Neuroplastin (NPTN) 6.6
Other
Click to Show/Hide to Show 127 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 99.7
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 93.1
 LDTP19859  Small integral membrane protein 12 (SMIM12) 82.7
 LDTP11076  Apolipoprotein L2 (APOL2) 53.4
 LDTP13797  HIG1 domain family member 1A, mitochondrial (HIGD1A) 52.0
 LDTP03678  ER lumen protein-retaining receptor 2 (KDELR2) 44.3
 LDTP05375  Nucleobindin-1 (NUCB1) 43.7
 LDTP19780  Keratinocyte-associated transmembrane protein 2 (KCT2) 41.9
 LDTP01522  Reticulon-3 (RTN3) 41.6
 LDTP10056  Protein FAM162A (FAM162A) 41.4
 LDTP05160  Nucleobindin-2 (NUCB2) 39.1
 LDTP13086  Syntaxin-18 (STX18) 39.1
 LDTP13902  Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) 38.3
 LDTP08224  Protein LYRIC (MTDH) 35.8
 LDTP03926  Centrin-2 (CETN2) 34.8
 LDTP15269  Large ribosomal subunit protein mL55 (MRPL55) 34.1
 LDTP18373  Thioredoxin-related transmembrane protein 4 (TMX4) 34.1
 LDTP12412  Reticulon-4 (RTN4) 32.0
 LDTP06097  Reticulocalbin-2 (RCN2) 29.2
 LDTP00105  Protein unc-119 homolog B (UNC119B) 26.9
 LDTP01167  Reticulon-2 (RTN2) 26.2
 LDTP18883  Protein CEBPZOS (CEBPZOS) 26.0
 LDTP00850  ER lumen protein-retaining receptor 3 (KDELR3) 24.8
 LDTP13311  Poly(U)-binding-splicing factor PUF60 (PUF60) 22.6
 LDTP16006  Optic atrophy 3 protein (OPA3) 22.5
 LDTP15240  LysM and putative peptidoglycan-binding domain-containing protein 3 (LYSMD3) 20.3
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 19.8
 LDTP00986  Syntaxin-10 (STX10) 19.6
 LDTP14458  Tetraspanin-6 (TSPAN6) 19.4
 LDTP09773  Protein FAM3C (FAM3C) 19.3
 LDTP08904  Protein jagunal homolog 1 (JAGN1) 19.3
 LDTP09679  Negative elongation factor B (NELFB) 18.9
 LDTP16080  Protein FAM114A2 (FAM114A2) 18.6
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 18.5
 LDTP11981  Receptor expression-enhancing protein 4 (REEP4) 18.1
 LDTP01494  Protein YIF1A (YIF1A) 18.0
 LDTP00859  Synaptogyrin-2 (SYNGR2) 18.0
 LDTP03968  Lamina-associated polypeptide 2, isoforms beta/gamma (TMPO) 17.6
 LDTP13630  Neudesin (NENF) 17.4
 LDTP06121  Caprin-1 (CAPRIN1) 16.2
 LDTP12755  OCIA domain-containing protein 1 (OCIAD1) 15.8
 LDTP10924  Prohibitin-2 (PHB2) 15.8
 LDTP16323  Signal recognition particle receptor subunit beta (SRPRB) 15.1
 LDTP01359  Dynactin subunit 3 (DCTN3) 14.9
 LDTP04356  Emerin (EMD) 14.8
 LDTP06892  Protein Hikeshi (HIKESHI) 14.3
 LDTP11389  Bcl-2-like protein 13 (BCL2L13) 13.8
 LDTP14939  Membralin (TMEM259) 13.7
 LDTP07964  Golgi to ER traffic protein 4 homolog (GET4) 13.6
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 13.6
 LDTP11911  Golgi phosphoprotein 3 (GOLPH3) 13.5
 LDTP15398  Protein FAM177A1 (FAM177A1) 13.4
 LDTP05960  Trophoblast glycoprotein (TPBG) 13.2
 LDTP15623  Neuferricin (CYB5D2) 12.6
 LDTP12468  Diablo IAP-binding mitochondrial protein (DIABLO) 12.6
 LDTP00729  Glycosylphosphatidylinositol anchor attachment 1 protein (GPAA1) 12.5
 LDTP10357  RUS family member 1 (RUSF1) 12.4
 LDTP19963  TraB domain-containing protein (TRABD) 12.1
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 12.0
 LDTP04207  Heat shock 70 kDa protein 13 (HSPA13) 12.0
 LDTP08689  Dyslexia-associated protein KIAA0319-like protein (KIAA0319L) 11.6
 LDTP10775  Endoplasmic reticulum-Golgi intermediate compartment protein 2 (ERGIC2) 11.6
 LDTP06373  Mitochondrial import receptor subunit TOM20 homolog (TOMM20) 11.5
 LDTP12379  Complex I assembly factor TIMMDC1, mitochondrial (TIMMDC1) 11.0
 LDTP07274  MICOS complex subunit MIC13 (MICOS13) 11.0
 LDTP11906  Phosphatidylinositol glycan anchor biosynthesis class U protein (PIGU) 10.6
 LDTP13802  DNA replication complex GINS protein PSF2 (GINS2) 10.6
 LDTP04241  Nuclear autoantigenic sperm protein (NASP) 10.6
 LDTP13967  Transmembrane emp24 domain-containing protein 5 (TMED5) 10.6
 LDTP05257  Receptor expression-enhancing protein 5 (REEP5) 10.2
 LDTP07934  Synaptic vesicle glycoprotein 2A (SV2A) 10.2
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 10.1
 LDTP05715  Vesicle transport protein SEC20 (BNIP1) 10.1
 LDTP09644  m-AAA protease-interacting protein 1, mitochondrial (MAIP1) 10.0
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 9.7
 LDTP02124  Keratin, type I cytoskeletal 18 (KRT18) 9.6
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 9.5
 LDTP02297  Vimentin (VIM) 9.4
 LDTP12571  LanC-like protein 2 (LANCL2) 9.4
 LDTP16285  Transducin beta-like protein 2 (TBL2) 9.3
 LDTP08793  Armadillo repeat-containing protein 10 (ARMC10) 9.2
 LDTP02443  Calmodulin-3 (CALM3) 9.2
 LDTP07368  Tetratricopeptide repeat protein 19, mitochondrial (TTC19) 9.1
 LDTP07891  Inhibitor of nuclear factor kappa-B kinase-interacting protein (IKBIP) 8.9
 LDTP05530  Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) 8.9
 LDTP16192  Mitochondrial fission process protein 1 (MTFP1) 8.8
 LDTP17659  ELMO domain-containing protein 2 (ELMOD2) 8.7
 LDTP15283  Nucleolar protein 9 (NOP9) 8.7
 LDTP11140  Peroxiredoxin-like 2A (PRXL2A) 8.7
 LDTP00887  Calumenin (CALU) 8.6
 LDTP07718  MICOS complex subunit MIC27 (APOOL) 8.6
 LDTP11670  Mitochondrial fission factor (MFF) 8.5
 LDTP10469  Engulfment and cell motility protein 2 (ELMO2) 8.4
 LDTP08594  Negative elongation factor C/D (NELFCD) 8.3
 LDTP07632  Type-1 angiotensin II receptor-associated protein (AGTRAP) 8.2
 LDTP09881  TATA-binding protein-associated factor 2N (TAF15) 8.1
 LDTP09850  Proline-rich protein PRCC (PRCC) 8.1
 LDTP04941  Coatomer subunit zeta-1 (COPZ1) 7.9
 LDTP15887  Lipase maturation factor 2 (LMF2) 7.8
 LDTP00632  Syntaxin-7 (STX7) 7.8
 LDTP03775  RNA-binding protein FUS (FUS) 7.8
 LDTP11134  DNA replication complex GINS protein SLD5 (GINS4) 7.7
 LDTP06291  ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL6IP1) 7.7
 LDTP10849  Regulator of microtubule dynamics protein 3 (RMDN3) 7.7
 LDTP05484  Proteasome activator complex subunit 1 (PSME1) 7.6
 LDTP02927  Ganglioside GM2 activator (GM2A) 7.5
 LDTP10403  DDRGK domain-containing protein 1 (DDRGK1) 7.4
 LDTP04684  Nucleosome assembly protein 1-like 1 (NAP1L1) 7.3
 LDTP12762  Transmembrane protein 161A (TMEM161A) 7.3
 LDTP11210  Transmembrane protein 43 (TMEM43) 7.3
 LDTP09069  Kinetochore protein Spc24 (SPC24) 7.2
 LDTP01213  Cell division control protein 45 homolog (CDC45) 7.1
 LDTP06022  Cold-inducible RNA-binding protein (CIRBP) 7.1
 LDTP09920  Golgi apparatus protein 1 (GLG1) 7.1
 LDTP17157  OCIA domain-containing protein 2 (OCIAD2) 7.0
 LDTP19625  Integral membrane protein GPR180 (GPR180) 6.9
 LDTP08153  Transmembrane emp24 domain-containing protein 4 (TMED4) 6.9
 LDTP18272  Transmembrane protein 209 (TMEM209) 6.9
 LDTP11326  FUN14 domain-containing protein 2 (FUNDC2) 6.9
 LDTP05685  Transmembrane protein 115 (TMEM115) 6.7
 LDTP05318  RNA-binding protein EWS (EWSR1) 6.6
 LDTP10062  Synapse-associated protein 1 (SYAP1) 6.6
 LDTP11978  HAUS augmin-like complex subunit 4 (HAUS4) 6.6
 LDTP00500  Heterogeneous nuclear ribonucleoprotein D-like (HNRNPDL) 6.6
 LDTP03850  RNA-binding motif protein, X chromosome (RBMX) 6.6
 LDTP04425  Translocon-associated protein subunit delta (SSR4) 6.5
 LDTP13604  Hippocalcin-like protein 4 (HPCAL4) 6.4

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587