Details of the Target

General Information of Target

Target ID LDTP11981
Target Name Receptor expression-enhancing protein 4 (REEP4)
Gene Name REEP4
Gene ID 80346
Synonyms
C8orf20; Receptor expression-enhancing protein 4
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAAVDSDVESLPRGGFRCCLCHVTTANRPSLDAHLGGRKHRHLVELRAARKAQGLRSVFV
SGFPRDVDSAQLSEYFLAFGPVASVVMDKDKGVFAIVEMGDVGAREAVLSQSQHSLGGHR
LRVRPREQKEFQSPASKSPKGAAPDSHQLAKALAEAADVGAQMIKLVGLRELSEAERQLR
SLVVALMQEVFTEFFPGCVVHPFGSSINSFDVHGCDLDLFLDLGDLEEPQPVPKAPESPS
LDSALASPLDPQALACTPASPPDSQPPASPQDSEALDFETPSSSLAPQTPDSALASETLA
SPQSLPPASPLLEDREEGDLGKASELAETPKEEKAEGAAMLELVGSILRGCVPGVYRVQT
VPSARRPVVKFCHRPSGLHGDVSLSNRLALHNSRFLSLCSELDGRVRPLVYTLRCWAQGR
GLSGSGPLLSNYALTLLVIYFLQTRDPPVLPTVSQLTQKAGEGEQVEVDGWDCSFPRDAS
RLEPSINVEPLSSLLAQFFSCVSCWDLRGSLLSLREGQALPVAGGLPSNLWEGLRLGPLN
LQDPFDLSHNVAANVTSRVAGRLQNCCRAAANYCRSLQYQRRSSRGRDWGLLPLLQPSSP
SSLLSATPIPLPLAPFTQLTAALVQVFREALGCHIEQATKRTRSEGGGTGESSQGGTSKR
LKVDGQKNCCEEGKEEQQGCAGDGGEDRVEEMVIEVGEMVQDWAMQSPGQPGDLPLTTGK
HGAPGEEGQPSHAALAERGPKGHEAAQEWSQGEAGKGASLPSSASWRCALWHRVWQGRRR
ARRRLQQQTKEGAGGGAGTRAGWLATEAQVTQELKGLSGGEERPETEPLLSFVASVSPAD
RMLTVTPLQDPQGLFPDLHHFLQVFLPQAIRHLK
Target Bioclass
Other
Family
DP1 family
Subcellular location
Endoplasmic reticulum membrane
Function
Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the endoplasmic reticulum membrane from metaphase chromosomes.
Uniprot ID
Q9H6H4
Ensemble ID
ENST00000306306.8
HGNC ID
HGNC:26176

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HDMYZ SNV: p.A71G .
HEC1 SNV: p.V92I .
HEC1B SNV: p.V92I .
LS123 SNV: p.A51G .
MELHO SNV: p.A51G .
MOLT4 SNV: p.E34K .
NCIH1048 SNV: p.P233L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.72  LDD0402  [1]
HDSF-alk
 Probe Info  		1.81  LDD0197  [2]
CHEMBL5175495
 Probe Info  		8.74  LDD0196  [3]
TH211
 Probe Info  		Y115(15.32)  LDD0257  [4]
TH216
 Probe Info  		Y115(20.00)  LDD0259  [4]
STPyne
 Probe Info  		K111(10.00); K123(10.00); K90(3.03)  LDD0277  [5]
IA-alkyne
 Probe Info  		C200(9.81)  LDD2157  [6]
Acrolein
 Probe Info  		N.A.  LDD0223  [7]
DBIA
 Probe Info  		C7(1.20)  LDD0593  [8]
IPM
 Probe Info  		N.A.  LDD0025  [9]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [10]
AOyne
 Probe Info  		14.10  LDD0443  [11]
PAL-AfBPP Probe
Click To Hide/Show 37 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C027
 Probe Info  		5.62  LDD1733  [12]
C040
 Probe Info  		18.13  LDD1740  [12]
C056
 Probe Info  		18.00  LDD1753  [12]
C063
 Probe Info  		11.39  LDD1760  [12]
C091
 Probe Info  		15.35  LDD1782  [12]
C092
 Probe Info  		28.84  LDD1783  [12]
C094
 Probe Info  		40.50  LDD1785  [12]
C106
 Probe Info  		18.25  LDD1793  [12]
C112
 Probe Info  		20.53  LDD1799  [12]
C134
 Probe Info  		20.39  LDD1816  [12]
C143
 Probe Info  		14.22  LDD1825  [12]
C159
 Probe Info  		7.52  LDD1839  [12]
C161
 Probe Info  		10.56  LDD1841  [12]
C169
 Probe Info  		32.00  LDD1849  [12]
C196
 Probe Info  		11.79  LDD1872  [12]
C198
 Probe Info  		9.71  LDD1874  [12]
C201
 Probe Info  		41.36  LDD1877  [12]
C206
 Probe Info  		21.86  LDD1881  [12]
C218
 Probe Info  		14.93  LDD1892  [12]
C220
 Probe Info  		15.89  LDD1894  [12]
C228
 Probe Info  		28.05  LDD1901  [12]
C231
 Probe Info  		14.32  LDD1904  [12]
C235
 Probe Info  		16.68  LDD1908  [12]
C289
 Probe Info  		38.32  LDD1959  [12]
C293
 Probe Info  		30.70  LDD1963  [12]
C296
 Probe Info  		13.64  LDD1966  [12]
C343
 Probe Info  		13.36  LDD2005  [12]
C349
 Probe Info  		9.51  LDD2010  [12]
C350
 Probe Info  		29.24  LDD2011  [12]
C362
 Probe Info  		53.08  LDD2023  [12]
C363
 Probe Info  		15.67  LDD2024  [12]
C364
 Probe Info  		15.89  LDD2025  [12]
C366
 Probe Info  		6.87  LDD2027  [12]
C388
 Probe Info  		53.45  LDD2047  [12]
C403
 Probe Info  		16.56  LDD2061  [12]
C407
 Probe Info  		14.12  LDD2064  [12]
OEA-DA
 Probe Info  		10.84  LDD0046  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C7(1.29)  LDD0812  [8]
 LDCM0215  AC10 HEK-293T C7(1.38)  LDD0813  [8]
 LDCM0216  AC100 HEK-293T C7(1.10)  LDD0814  [8]
 LDCM0217  AC101 HEK-293T C7(0.81)  LDD0815  [8]
 LDCM0218  AC102 HEK-293T C7(0.91)  LDD0816  [8]
 LDCM0219  AC103 HEK-293T C7(0.99)  LDD0817  [8]
 LDCM0220  AC104 HEK-293T C7(0.99)  LDD0818  [8]
 LDCM0221  AC105 HEK-293T C7(0.90)  LDD0819  [8]
 LDCM0222  AC106 HEK-293T C7(0.79)  LDD0820  [8]
 LDCM0223  AC107 HEK-293T C7(0.93)  LDD0821  [8]
 LDCM0224  AC108 HEK-293T C7(0.94)  LDD0822  [8]
 LDCM0225  AC109 HEK-293T C7(1.03)  LDD0823  [8]
 LDCM0226  AC11 HEK-293T C7(1.37)  LDD0824  [8]
 LDCM0227  AC110 HEK-293T C7(1.01)  LDD0825  [8]
 LDCM0228  AC111 HEK-293T C7(1.34)  LDD0826  [8]
 LDCM0229  AC112 HEK-293T C7(1.05)  LDD0827  [8]
 LDCM0230  AC113 HEK-293T C7(1.02)  LDD0828  [8]
 LDCM0231  AC114 HEK-293T C7(0.97)  LDD0829  [8]
 LDCM0232  AC115 HEK-293T C7(1.15)  LDD0830  [8]
 LDCM0233  AC116 HEK-293T C7(1.06)  LDD0831  [8]
 LDCM0234  AC117 HEK-293T C7(1.02)  LDD0832  [8]
 LDCM0235  AC118 HEK-293T C7(1.01)  LDD0833  [8]
 LDCM0236  AC119 HEK-293T C7(1.13)  LDD0834  [8]
 LDCM0237  AC12 HEK-293T C7(1.38)  LDD0835  [8]
 LDCM0238  AC120 HEK-293T C7(0.96)  LDD0836  [8]
 LDCM0239  AC121 HEK-293T C7(1.30)  LDD0837  [8]
 LDCM0240  AC122 HEK-293T C7(1.23)  LDD0838  [8]
 LDCM0241  AC123 HEK-293T C7(1.26)  LDD0839  [8]
 LDCM0242  AC124 HEK-293T C7(1.11)  LDD0840  [8]
 LDCM0243  AC125 HEK-293T C7(1.29)  LDD0841  [8]
 LDCM0244  AC126 HEK-293T C7(1.28)  LDD0842  [8]
 LDCM0245  AC127 HEK-293T C7(1.40)  LDD0843  [8]
 LDCM0259  AC14 HEK-293T C7(1.40)  LDD0857  [8]
 LDCM0263  AC143 HEK-293T C7(0.99)  LDD0861  [8]
 LDCM0264  AC144 HEK-293T C7(1.30)  LDD0862  [8]
 LDCM0265  AC145 HEK-293T C7(1.15)  LDD0863  [8]
 LDCM0266  AC146 HEK-293T C7(1.09)  LDD0864  [8]
 LDCM0267  AC147 HEK-293T C7(1.36)  LDD0865  [8]
 LDCM0268  AC148 HEK-293T C7(1.54)  LDD0866  [8]
 LDCM0269  AC149 HEK-293T C7(0.89)  LDD0867  [8]
 LDCM0270  AC15 HEK-293T C7(1.50)  LDD0868  [8]
 LDCM0271  AC150 HEK-293T C7(1.17)  LDD0869  [8]
 LDCM0272  AC151 HEK-293T C7(1.15)  LDD0870  [8]
 LDCM0273  AC152 HEK-293T C7(1.15)  LDD0871  [8]
 LDCM0274  AC153 HEK-293T C7(1.15)  LDD0872  [8]
 LDCM0621  AC154 HEK-293T C7(1.08)  LDD2162  [8]
 LDCM0622  AC155 HEK-293T C7(1.16)  LDD2163  [8]
 LDCM0623  AC156 HEK-293T C7(1.22)  LDD2164  [8]
 LDCM0624  AC157 HEK-293T C7(1.38)  LDD2165  [8]
 LDCM0276  AC17 HCT 116 C7(1.20)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C7(0.97)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C7(1.07)  LDD0595  [8]
 LDCM0279  AC2 HEK-293T C7(1.12)  LDD0877  [8]
 LDCM0280  AC20 HCT 116 C7(0.94)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C7(1.29)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C7(1.15)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C7(1.17)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C7(0.94)  LDD0601  [8]
 LDCM0285  AC25 HEK-293T C7(0.91)  LDD0883  [8]
 LDCM0286  AC26 HEK-293T C7(0.88)  LDD0884  [8]
 LDCM0287  AC27 HEK-293T C7(0.88)  LDD0885  [8]
 LDCM0288  AC28 HEK-293T C7(1.06)  LDD0886  [8]
 LDCM0289  AC29 HEK-293T C7(0.93)  LDD0887  [8]
 LDCM0290  AC3 HEK-293T C7(1.18)  LDD0888  [8]
 LDCM0291  AC30 HEK-293T C7(0.90)  LDD0889  [8]
 LDCM0292  AC31 HEK-293T C7(0.92)  LDD0890  [8]
 LDCM0293  AC32 HEK-293T C7(0.80)  LDD0891  [8]
 LDCM0294  AC33 HEK-293T C7(0.87)  LDD0892  [8]
 LDCM0295  AC34 HEK-293T C7(0.81)  LDD0893  [8]
 LDCM0296  AC35 HEK-293T C7(1.10); C18(0.83); C200(0.97)  LDD1535  [14]
 LDCM0297  AC36 HEK-293T C7(0.93)  LDD1536  [14]
 LDCM0298  AC37 HEK-293T C7(1.12)  LDD1537  [14]
 LDCM0299  AC38 HEK-293T C7(1.07); C200(0.93)  LDD1538  [14]
 LDCM0300  AC39 HEK-293T C7(1.01); C18(1.25); C200(0.90)  LDD1539  [14]
 LDCM0301  AC4 HEK-293T C7(1.50)  LDD0899  [8]
 LDCM0302  AC40 HEK-293T C7(0.90); C18(1.20)  LDD1541  [14]
 LDCM0303  AC41 HEK-293T C7(0.92); C200(1.09)  LDD1542  [14]
 LDCM0304  AC42 HEK-293T C7(0.93); C200(0.89)  LDD1543  [14]
 LDCM0305  AC43 HEK-293T C7(1.12); C18(1.10); C200(1.12)  LDD1544  [14]
 LDCM0306  AC44 HEK-293T C7(1.02)  LDD1545  [14]
 LDCM0307  AC45 HEK-293T C7(0.90)  LDD1546  [14]
 LDCM0308  AC46 HCT 116 C7(0.82)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C7(0.91)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C7(0.86)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C7(1.02)  LDD0628  [8]
 LDCM0312  AC5 HEK-293T C7(1.15)  LDD0910  [8]
 LDCM0313  AC50 HCT 116 C7(1.02)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C7(0.98)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C7(0.95)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C7(1.09)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C7(0.96)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C7(1.04)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C7(1.17)  LDD0636  [8]
 LDCM0320  AC57 HCT 116 C7(0.81)  LDD0637  [8]
 LDCM0321  AC58 HCT 116 C7(0.90)  LDD0638  [8]
 LDCM0322  AC59 HCT 116 C7(1.05)  LDD0639  [8]
 LDCM0323  AC6 HEK-293T C7(1.11)  LDD0921  [8]
 LDCM0324  AC60 HCT 116 C7(0.96)  LDD0641  [8]
 LDCM0325  AC61 HCT 116 C7(0.77)  LDD0642  [8]
 LDCM0326  AC62 HCT 116 C7(1.04)  LDD0643  [8]
 LDCM0327  AC63 HCT 116 C7(0.99)  LDD0644  [8]
 LDCM0328  AC64 HCT 116 C7(1.00)  LDD0645  [8]
 LDCM0329  AC65 HCT 116 C7(1.14)  LDD0646  [8]
 LDCM0330  AC66 HCT 116 C7(1.14)  LDD0647  [8]
 LDCM0331  AC67 HCT 116 C7(1.02)  LDD0648  [8]
 LDCM0332  AC68 HEK-293T C7(1.10)  LDD0930  [8]
 LDCM0333  AC69 HEK-293T C7(0.93)  LDD0931  [8]
 LDCM0334  AC7 HEK-293T C7(1.32)  LDD0932  [8]
 LDCM0335  AC70 HEK-293T C7(1.00)  LDD0933  [8]
 LDCM0336  AC71 HEK-293T C7(1.01)  LDD0934  [8]
 LDCM0337  AC72 HEK-293T C7(1.01)  LDD0935  [8]
 LDCM0338  AC73 HEK-293T C7(0.85)  LDD0936  [8]
 LDCM0339  AC74 HEK-293T C7(1.44)  LDD0937  [8]
 LDCM0340  AC75 HEK-293T C7(1.24)  LDD0938  [8]
 LDCM0341  AC76 HEK-293T C7(1.07)  LDD0939  [8]
 LDCM0342  AC77 HEK-293T C7(1.03)  LDD0940  [8]
 LDCM0343  AC78 HEK-293T C7(1.02)  LDD0941  [8]
 LDCM0344  AC79 HEK-293T C7(1.09)  LDD0942  [8]
 LDCM0345  AC8 HEK-293T C7(1.31)  LDD0943  [8]
 LDCM0346  AC80 HEK-293T C7(1.12)  LDD0944  [8]
 LDCM0347  AC81 HEK-293T C7(1.13)  LDD0945  [8]
 LDCM0348  AC82 HEK-293T C7(1.10)  LDD0946  [8]
 LDCM0349  AC83 HCT 116 C7(0.63)  LDD0666  [8]
 LDCM0350  AC84 HCT 116 C7(0.56)  LDD0667  [8]
 LDCM0351  AC85 HCT 116 C7(0.79)  LDD0668  [8]
 LDCM0352  AC86 HCT 116 C7(0.67)  LDD0669  [8]
 LDCM0353  AC87 HCT 116 C7(1.08)  LDD0670  [8]
 LDCM0354  AC88 HCT 116 C7(0.75)  LDD0671  [8]
 LDCM0355  AC89 HCT 116 C7(0.78)  LDD0672  [8]
 LDCM0357  AC90 HCT 116 C7(2.03)  LDD0674  [8]
 LDCM0358  AC91 HCT 116 C7(0.77)  LDD0675  [8]
 LDCM0359  AC92 HCT 116 C7(1.10)  LDD0676  [8]
 LDCM0360  AC93 HCT 116 C7(0.95)  LDD0677  [8]
 LDCM0361  AC94 HCT 116 C7(1.52)  LDD0678  [8]
 LDCM0362  AC95 HCT 116 C7(1.21)  LDD0679  [8]
 LDCM0363  AC96 HCT 116 C7(1.13)  LDD0680  [8]
 LDCM0364  AC97 HCT 116 C7(1.41)  LDD0681  [8]
 LDCM0365  AC98 HEK-293T C7(0.89)  LDD0963  [8]
 LDCM0366  AC99 HEK-293T C7(0.78)  LDD0964  [8]
 LDCM0248  AKOS034007472 HEK-293T C7(1.50)  LDD0846  [8]
 LDCM0356  AKOS034007680 HEK-293T C7(1.65)  LDD0954  [8]
 LDCM0275  AKOS034007705 HEK-293T C7(1.41)  LDD0873  [8]
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [1]
 LDCM0367  CL1 HCT 116 C7(1.32)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C7(1.19)  LDD0685  [8]
 LDCM0369  CL100 HEK-293T C7(1.30)  LDD0967  [8]
 LDCM0370  CL101 HEK-293T C7(1.28)  LDD0968  [8]
 LDCM0371  CL102 HEK-293T C7(1.33)  LDD0969  [8]
 LDCM0372  CL103 HEK-293T C7(1.22)  LDD0970  [8]
 LDCM0373  CL104 HEK-293T C7(1.32)  LDD0971  [8]
 LDCM0374  CL105 HCT 116 C7(1.11)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C7(1.17)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C7(1.11)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C7(1.39)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C7(1.16)  LDD0695  [8]
 LDCM0379  CL11 HCT 116 C7(1.22)  LDD0696  [8]
 LDCM0380  CL110 HCT 116 C7(1.02)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C7(1.07)  LDD0698  [8]
 LDCM0382  CL112 HEK-293T C7(0.98)  LDD0980  [8]
 LDCM0383  CL113 HEK-293T C7(0.91)  LDD0981  [8]
 LDCM0384  CL114 HEK-293T C7(0.90)  LDD0982  [8]
 LDCM0385  CL115 HEK-293T C7(0.92)  LDD0983  [8]
 LDCM0386  CL116 HEK-293T C7(0.90)  LDD0984  [8]
 LDCM0387  CL117 HEK-293T C7(1.08); C18(0.79)  LDD1591  [14]
 LDCM0388  CL118 HEK-293T C7(0.94); C18(1.15)  LDD1592  [14]
 LDCM0389  CL119 HEK-293T C7(1.17)  LDD1593  [14]
 LDCM0390  CL12 HCT 116 C7(1.18)  LDD0707  [8]
 LDCM0391  CL120 HEK-293T C7(0.95)  LDD1595  [14]
 LDCM0392  CL121 HCT 116 C7(1.10)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C7(0.94)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C7(1.11)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C7(1.21)  LDD0712  [8]
 LDCM0396  CL125 HCT 116 C7(0.93)  LDD0713  [8]
 LDCM0397  CL126 HCT 116 C7(3.13)  LDD0714  [8]
 LDCM0398  CL127 HCT 116 C7(0.92)  LDD0715  [8]
 LDCM0399  CL128 HCT 116 C7(0.84)  LDD0716  [8]
 LDCM0400  CL13 HCT 116 C7(1.14)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C7(1.27)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C7(1.23)  LDD0719  [8]
 LDCM0403  CL16 HEK-293T C7(0.96)  LDD1607  [14]
 LDCM0404  CL17 HEK-293T C7(1.48); C200(1.28)  LDD1608  [14]
 LDCM0405  CL18 HEK-293T C7(1.15); C200(1.07)  LDD1609  [14]
 LDCM0406  CL19 HEK-293T C7(1.02); C18(1.08); C200(1.18)  LDD1610  [14]
 LDCM0407  CL2 HCT 116 C7(1.11)  LDD0724  [8]
 LDCM0408  CL20 HEK-293T C7(1.08)  LDD1612  [14]
 LDCM0409  CL21 HEK-293T C7(1.21)  LDD1613  [14]
 LDCM0410  CL22 HEK-293T C7(1.27); C200(1.01)  LDD1614  [14]
 LDCM0411  CL23 HEK-293T C7(1.54); C18(1.26); C200(1.00)  LDD1615  [14]
 LDCM0412  CL24 HEK-293T C7(1.29); C18(1.37)  LDD1616  [14]
 LDCM0413  CL25 HEK-293T C7(1.05); C18(0.61)  LDD1617  [14]
 LDCM0414  CL26 HEK-293T C7(1.00); C18(1.02)  LDD1618  [14]
 LDCM0415  CL27 HEK-293T C7(1.01)  LDD1619  [14]
 LDCM0416  CL28 HEK-293T C7(1.03)  LDD1620  [14]
 LDCM0417  CL29 HEK-293T C7(0.92); C200(0.79)  LDD1621  [14]
 LDCM0418  CL3 HCT 116 C7(1.07)  LDD0735  [8]
 LDCM0419  CL30 HEK-293T C7(1.04); C200(0.94)  LDD1623  [14]
 LDCM0420  CL31 HEK-293T C7(0.82)  LDD1018  [8]
 LDCM0421  CL32 HEK-293T C7(0.87)  LDD1019  [8]
 LDCM0422  CL33 HEK-293T C7(0.85)  LDD1020  [8]
 LDCM0423  CL34 HEK-293T C7(0.92)  LDD1021  [8]
 LDCM0424  CL35 HEK-293T C7(0.84)  LDD1022  [8]
 LDCM0425  CL36 HEK-293T C7(0.83)  LDD1023  [8]
 LDCM0426  CL37 HEK-293T C7(0.87)  LDD1024  [8]
 LDCM0428  CL39 HEK-293T C7(1.07)  LDD1026  [8]
 LDCM0429  CL4 HCT 116 C7(1.25)  LDD0746  [8]
 LDCM0430  CL40 HEK-293T C7(0.94)  LDD1028  [8]
 LDCM0431  CL41 HEK-293T C7(1.14)  LDD1029  [8]
 LDCM0432  CL42 HEK-293T C7(1.10)  LDD1030  [8]
 LDCM0433  CL43 HEK-293T C7(1.12)  LDD1031  [8]
 LDCM0434  CL44 HEK-293T C7(0.77)  LDD1032  [8]
 LDCM0435  CL45 HEK-293T C7(1.01)  LDD1033  [8]
 LDCM0436  CL46 HEK-293T C7(1.18); C200(0.76)  LDD1640  [14]
 LDCM0437  CL47 HEK-293T C7(1.20); C18(1.44); C200(1.09)  LDD1641  [14]
 LDCM0438  CL48 HEK-293T C7(1.05); C18(1.34)  LDD1642  [14]
 LDCM0439  CL49 HEK-293T C7(1.24); C18(0.61)  LDD1643  [14]
 LDCM0440  CL5 HCT 116 C7(1.11)  LDD0757  [8]
 LDCM0441  CL50 HEK-293T C7(1.09); C18(1.06)  LDD1645  [14]
 LDCM0443  CL52 HEK-293T C7(0.83)  LDD1646  [14]
 LDCM0444  CL53 HEK-293T C7(1.51); C200(0.98)  LDD1647  [14]
 LDCM0445  CL54 HEK-293T C7(1.58); C200(0.81)  LDD1648  [14]
 LDCM0446  CL55 HEK-293T C7(1.09); C18(1.05); C200(1.02)  LDD1649  [14]
 LDCM0447  CL56 HEK-293T C7(1.05)  LDD1650  [14]
 LDCM0448  CL57 HEK-293T C7(1.09)  LDD1651  [14]
 LDCM0449  CL58 HEK-293T C7(1.30); C200(0.88)  LDD1652  [14]
 LDCM0450  CL59 HEK-293T C7(1.45); C18(1.10); C200(0.89)  LDD1653  [14]
 LDCM0451  CL6 HCT 116 C7(0.94)  LDD0768  [8]
 LDCM0452  CL60 HEK-293T C7(1.12); C18(1.88)  LDD1655  [14]
 LDCM0453  CL61 HEK-293T C7(1.21); C18(0.67)  LDD1656  [14]
 LDCM0454  CL62 HEK-293T C7(1.04); C18(1.31)  LDD1657  [14]
 LDCM0455  CL63 HEK-293T C7(0.96)  LDD1658  [14]
 LDCM0456  CL64 HEK-293T C7(1.13)  LDD1659  [14]
 LDCM0457  CL65 HEK-293T C7(1.01); C200(0.86)  LDD1660  [14]
 LDCM0458  CL66 HEK-293T C7(1.15); C200(1.72)  LDD1661  [14]
 LDCM0459  CL67 HEK-293T C7(1.25); C18(1.37); C200(1.42)  LDD1662  [14]
 LDCM0460  CL68 HEK-293T C7(1.12)  LDD1663  [14]
 LDCM0461  CL69 HEK-293T C7(1.10)  LDD1664  [14]
 LDCM0462  CL7 HCT 116 C7(1.56)  LDD0779  [8]
 LDCM0463  CL70 HEK-293T C7(1.19); C200(1.16)  LDD1666  [14]
 LDCM0464  CL71 HEK-293T C7(1.12); C18(1.24); C200(1.05)  LDD1667  [14]
 LDCM0465  CL72 HEK-293T C7(1.06); C18(1.32)  LDD1668  [14]
 LDCM0466  CL73 HEK-293T C7(1.09); C18(0.80)  LDD1669  [14]
 LDCM0467  CL74 HEK-293T C7(0.98); C18(1.02)  LDD1670  [14]
 LDCM0469  CL76 HEK-293T C7(0.77)  LDD1067  [8]
 LDCM0470  CL77 HEK-293T C7(0.96)  LDD1068  [8]
 LDCM0471  CL78 HEK-293T C7(0.84)  LDD1069  [8]
 LDCM0472  CL79 HEK-293T C7(1.09)  LDD1070  [8]
 LDCM0473  CL8 HCT 116 C7(1.77)  LDD0790  [8]
 LDCM0474  CL80 HEK-293T C7(0.95)  LDD1072  [8]
 LDCM0475  CL81 HEK-293T C7(0.93)  LDD1073  [8]
 LDCM0476  CL82 HEK-293T C7(1.15)  LDD1074  [8]
 LDCM0477  CL83 HEK-293T C7(1.06)  LDD1075  [8]
 LDCM0478  CL84 HEK-293T C7(0.85)  LDD1076  [8]
 LDCM0479  CL85 HEK-293T C7(1.07)  LDD1077  [8]
 LDCM0480  CL86 HEK-293T C7(0.74)  LDD1078  [8]
 LDCM0481  CL87 HEK-293T C7(1.07)  LDD1079  [8]
 LDCM0482  CL88 HEK-293T C7(1.14)  LDD1080  [8]
 LDCM0483  CL89 HEK-293T C7(0.92)  LDD1081  [8]
 LDCM0484  CL9 HCT 116 C7(1.08)  LDD0801  [8]
 LDCM0485  CL90 HEK-293T C7(1.12)  LDD1083  [8]
 LDCM0486  CL91 HEK-293T C7(1.43)  LDD1084  [8]
 LDCM0487  CL92 HEK-293T C7(1.43)  LDD1085  [8]
 LDCM0488  CL93 HEK-293T C7(1.23)  LDD1086  [8]
 LDCM0489  CL94 HEK-293T C7(1.19)  LDD1087  [8]
 LDCM0490  CL95 HEK-293T C7(1.56)  LDD1088  [8]
 LDCM0491  CL96 HEK-293T C7(1.09)  LDD1089  [8]
 LDCM0492  CL97 HEK-293T C7(1.07)  LDD1090  [8]
 LDCM0493  CL98 HEK-293T C7(1.20)  LDD1091  [8]
 LDCM0494  CL99 HEK-293T C7(1.17)  LDD1092  [8]
 LDCM0495  E2913 HEK-293T C7(0.99)  LDD1698  [14]
 LDCM0625  F8 Ramos C200(0.95); C7(0.60)  LDD2187  [15]
 LDCM0572  Fragment10 Ramos C200(1.24)  LDD2189  [15]
 LDCM0573  Fragment11 Ramos C200(0.58); C7(0.78)  LDD2190  [15]
 LDCM0574  Fragment12 Ramos C200(1.15)  LDD2191  [15]
 LDCM0575  Fragment13 Ramos C200(1.05)  LDD2192  [15]
 LDCM0576  Fragment14 Ramos C200(0.96); C7(2.07)  LDD2193  [15]
 LDCM0579  Fragment20 Ramos C200(1.32)  LDD2194  [15]
 LDCM0580  Fragment21 Ramos C200(1.02)  LDD2195  [15]
 LDCM0582  Fragment23 Ramos C200(1.75)  LDD2196  [15]
 LDCM0578  Fragment27 Ramos C200(1.05)  LDD2197  [15]
 LDCM0586  Fragment28 Ramos C200(0.87); C7(1.01)  LDD2198  [15]
 LDCM0588  Fragment30 Ramos C200(1.41)  LDD2199  [15]
 LDCM0589  Fragment31 Ramos C200(1.03)  LDD2200  [15]
 LDCM0590  Fragment32 Ramos C200(1.13)  LDD2201  [15]
 LDCM0468  Fragment33 HEK-293T C7(0.95)  LDD1671  [14]
 LDCM0596  Fragment38 Ramos C200(1.00)  LDD2203  [15]
 LDCM0566  Fragment4 Ramos C200(0.87); C7(1.08)  LDD2184  [15]
 LDCM0427  Fragment51 HEK-293T C7(0.86)  LDD1025  [8]
 LDCM0610  Fragment52 Ramos C200(0.98)  LDD2204  [15]
 LDCM0614  Fragment56 Ramos C200(1.13)  LDD2205  [15]
 LDCM0569  Fragment7 Ramos C200(0.88); C7(1.44)  LDD2186  [15]
 LDCM0571  Fragment9 Ramos C200(1.35)  LDD2188  [15]
 LDCM0022  KB02 HEK-293T C200(1.23)  LDD1492  [14]
 LDCM0023  KB03 HEK-293T C200(0.88)  LDD1497  [14]
 LDCM0024  KB05 HEK-293T C200(1.21)  LDD1502  [14]
 LDCM0109  NEM HeLa N.A.  LDD0223  [7]
 LDCM0627  NUDT7-COV-1 HEK-293T C200(1.14)  LDD2206  [16]
 LDCM0628  OTUB2-COV-1 HEK-293T C200(0.39)  LDD2207  [16]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 16 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
1-acyl-sn-glycerol-3-phosphate acyltransferase delta (AGPAT4) 1-acyl-sn-glycerol-3-phosphate acyltransferase family Q9NRZ5
3 beta-hydroxysteroid dehydrogenase type 7 (HSD3B7) 3-beta-HSD family Q9H2F3
Catechol O-methyltransferase (COMT) Cation-dependent O-methyltransferase family P21964
Cytochrome b5 type B (CYB5B) Cytochrome b5 family O43169
Cytochrome P450 4F2 (CYP4F2) Cytochrome P450 family P78329
Diacylglycerol O-acyltransferase 2-like protein 6 (DGAT2L6) Diacylglycerol acyltransferase family Q6ZPD8
NADH-cytochrome b5 reductase 3 (CYB5R3) Flavoprotein pyridine nucleotide cytochrome reductase family P00387
Flavin-containing monooxygenase 1 (FMO1) FMO family Q01740
Transmembrane protein with metallophosphoesterase domain (TMPPE) LOC643853 family Q6ZT21
Complement C1s subcomponent (C1S) Peptidase S1 family P09871
Squalene monooxygenase (SQLE) Squalene monooxygenase family Q14534
Lysoplasmalogenase TMEM86A (TMEM86A) TMEM86 family Q8N2M4
GTPase IMAP family member 1 (GIMAP1) AIG1/Toc34/Toc159-like paraseptin GTPase family Q8WWP7
UbiA prenyltransferase domain-containing protein 1 (UBIAD1) UbiA prenyltransferase family Q9Y5Z9
Ubiquitin-conjugating enzyme E2 J1 (UBE2J1) Ubiquitin-conjugating enzyme family Q9Y385
V-type proton ATPase 16 kDa proteolipid subunit c (ATP6V0C) V-ATPase proteolipid subunit family P27449
Transporter and channel
Click To Hide/Show 30 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Large neutral amino acids transporter small subunit 2 (SLC7A8) L-type amino acid transporter (LAT) (TC 2.A.3.8) family Q9UHI5
Bcl-2-like protein 1 (BCL2L1) Bcl-2 family Q07817
Proton-coupled zinc antiporter SLC30A8 (SLC30A8) Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family Q8IWU4
Interferon-induced transmembrane protein 3 (IFITM3) CD225/Dispanin family Q01628
Derlin-1 (DERL1) Derlin family Q9BUN8
Statherin (STATH) Histatin/statherin family P02808
Mitochondrial outer membrane protein SLC25A46 (SLC25A46) Mitochondrial carrier (TC 2.A.29) family Q96AG3
B-lymphocyte antigen CD20 (MS4A1) MS4A family P11836
Peroxisomal membrane protein PEX16 (PEX16) Peroxin-16 family Q9Y5Y5
Peripheral myelin protein 22 (PMP22) PMP-22/EMP/MP20 family Q01453
Voltage-dependent calcium channel gamma-1 subunit (CACNG1) PMP-22/EMP/MP20 family Q06432
PRA1 family protein 2 (PRAF2) PRA1 family O60831
Sideroflexin-1 (SFXN1) Sideroflexin family Q9H9B4
Sideroflexin-2 (SFXN2) Sideroflexin family Q96NB2
Small integral membrane protein 1 (SMIM1) SMIM1 family B2RUZ4
Syntaxin-3 (STX3) Syntaxin family Q13277
Syntaxin-5 (STX5) Syntaxin family Q13190
Mitochondrial import inner membrane translocase subunit Tim22 (TIMM22) Tim17/Tim22/Tim23 family Q9Y584
Ion channel TACAN (TMEM120A) TMEM120 family Q9BXJ8
Transmembrane protein 208 (TMEM208) TMEM208 family Q9BTX3
Transmembrane protein 50A (TMEM50A) UPF0220 family O95807
Vesicle-associated membrane protein-associated protein B/C (VAPB) VAMP-associated protein (VAP) (TC 9.B.17) family O95292
Vesicle transport through interaction with t-SNAREs homolog 1B (VTI1B) VTI1 family Q9UEU0
Phospholipid transfer protein C2CD2L (C2CD2L) . O14523
Proteolipid protein 2 (PLP2) . Q04941
Synaptojanin-2-binding protein (SYNJ2BP) . P57105
Thioredoxin-related transmembrane protein 2 (TMX2) . Q9Y320
Transmembrane protein 199 (TMEM199) . Q8N511
Transmembrane protein 60 (TMEM60) . Q9H2L4
Transmembrane protein 65 (TMEM65) . Q6PI78
Cytokine and receptor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CKLF-like MARVEL transmembrane domain-containing protein 3 (CMTM3) Chemokine-like factor family Q96MX0
C-C motif chemokine 4-like (CCL4L1; CCL4L2) Intercrine beta (chemokine CC) family Q8NHW4
Other
Click To Hide/Show 43 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
BET1 homolog (BET1) BET1 family O15155
Ergosterol biosynthetic protein 28 homolog (ERG28) ERG28 family Q9UKR5
FUN14 domain-containing protein 2 (FUNDC2) FUN14 family Q9BWH2
Glycophorin-B (GYPB) Glycophorin-A family P06028
Integrin alpha-M (ITGAM) Integrin alpha chain family P11215
Protein kish-B (TMEM167B) KISH family Q9NRX6
Protein MAL2 (MAL2) MAL family Q969L2
Leptin receptor overlapping transcript-like 1 (LEPROTL1) OB-RGRP/VPS55 family O95214
ORM1-like protein 1 (ORMDL1) ORM family Q9P0S3
Claudin domain-containing protein 2 (CLDND2) PMP-22/EMP/MP20 family Q8NHS1
Stress-associated endoplasmic reticulum protein 1 (SERP1) RAMP4 family Q9Y6X1
Selenoprotein K (SELENOK) Selenoprotein K family Q9Y6D0
Selenoprotein M (SELENOM) Selenoprotein M/F family Q8WWX9
Small EDRK-rich factor 1 (SERF1A; SERF1B) SERF family O75920
Vesicle transport protein SFT2A (SFT2D1) SFT2 family Q8WV19
Vesicle transport protein SFT2B (SFT2D2) SFT2 family O95562
Sideroflexin-3 (SFXN3) Sideroflexin family Q9BWM7
Small cell adhesion glycoprotein (SMAGP) SMAGP family Q0VAQ4
Vesicle-associated membrane protein 4 (VAMP4) Synaptobrevin family O75379
Vesicle-associated membrane protein 5 (VAMP5) Synaptobrevin family O95183
Vesicle-trafficking protein SEC22b (SEC22B) Synaptobrevin family O75396
Tetraspanin-2 (TSPAN2) Tetraspanin (TM4SF) family O60636
Bone morphogenetic protein 10 (BMP10) TGF-beta family O95393
Transmembrane protein 120B (TMEM120B) TMEM120 family A0PK00
Transmembrane protein 121 (TMEM121) TMEM121 family Q9BTD3
Transmembrane protein 19 (TMEM19) TMEM19 family Q96HH6
Transmembrane protein 229B (TMEM229B) TMEM229 family Q8NBD8
Receptor-transporting protein 2 (RTP2) TMEM7 family Q5QGT7
Receptor-transporting protein 4 (RTP4) TMEM7 family Q96DX8
Tumor protein p63-regulated gene 1 protein (TPRG1) TPRG1 family Q6ZUI0
Golgi apparatus membrane protein TVP23 homolog B (TVP23B) TVP23 family Q9NYZ1
Protein unc-50 homolog (UNC50) Unc-50 family Q53HI1
Protein YIF1A (YIF1A) YIF1 family O95070
Protein YIPF4 (YIPF4) YIP1 family Q9BSR8
Bcl-2-interacting killer (BIK) . Q13323
Cytoplasmic protein NCK2 (NCK2) . O43639
DnaJ homolog subfamily C member 30, mitochondrial (DNAJC30) . Q96LL9
Inner nuclear membrane protein Man1 (LEMD3) . Q9Y2U8
LEM domain-containing protein 1 (LEMD1) . Q68G75
Motile sperm domain-containing protein 3 (MOSPD3) . O75425
Nutritionally-regulated adipose and cardiac enriched protein homolog (NRAC) . Q8N912
Transmembrane protein 254 (TMEM254) . Q8TBM7
Transmembrane protein 51 (TMEM51) . Q9NW97

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Fatty Acyl Sulfonyl Fluoride as an Activity-Based Probe for Profiling Fatty Acid-Associated Proteins in Living Cells. Chembiochem. 2022 Feb 16;23(4):e202100628. doi: 10.1002/cbic.202100628. Epub 2021 Dec 30.
3 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 From chemoproteomic-detected amino acids to genomic coordinates: insights into precise multi-omic data integration. Mol Syst Biol. 2021 Feb;17(2):e9840. doi: 10.15252/msb.20209840.
Mass spectrometry data entry: PXD022151
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
11 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
12 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
13 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
15 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
16 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.