Details of the Probe

General Information of Probe

Probe ID
LDPC0584
Probe Name
C363
Synonyms
Z4225952184
Probe Type
PAL-AfBPP Probe
Structure
3D MOL 2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 349.31
Lipid-water partition coefficient (xlogp) 3.6
Rotatable Bond Count (rotbonds) 6
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 7
Chemical Identifiers
Formula
C16H14F3N5O
IUPAC Name
N-[2-(3-but-3-ynyldiazirin-3-yl)ethyl]-3-(trifluoromethyl)imidazo[1,5-a]pyridine-1-carboxamide
Canonical SMILES
C#CCCC1(N=N1)CCNC(=O)C2=C3C=CC=CN3C(=N2)C(F)(F)F
InChI
InChI=1S/C16H14F3N5O/c1-2-3-7-15(22-23-15)8-9-20-13(25)12-11-6-4-5-10-24(11)14(21-12)16(17,18)19/h1,4-6,10H,3,7-9H2,(H,20,25)
InChIKey
QMQWERCCSYPIQI-UHFFFAOYSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

123 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
2-hydroxyacylsphingosine 1-beta-galactosyltransferase (UGT8) LDTP06657 22.47  LDD2024 
5'-3' exonuclease PLD3 (PLD3) LDTP08476 35.75  LDD2024 
7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) LDTP10032 15.89  LDD2024 
Acetyl-CoA acetyltransferase, cytosolic (ACAT2) LDTP11321 58.89  LDD2024 
Acid ceramidase (ASAH1) LDTP05905 38.59  LDD2024 
Adenosine 5'-monophosphoramidase HINT3 (HINT3) LDTP12415 19.84  LDD2024 
Adenosine deaminase (ADA) LDTP01803 56.49  LDD2024 
ADP-dependent glucokinase (ADPGK) LDTP11127 22.63  LDD2024 
Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) LDTP04437 46.85  LDD2024 
Aldehyde dehydrogenase, mitochondrial (ALDH2) LDTP02074 16.22  LDD2024 
Alkyldihydroxyacetonephosphate synthase, peroxisomal (AGPS) LDTP00186 17.15  LDD2024 
Alpha-galactosidase A (GLA) LDTP02141 17.75  LDD2024 
Alpha-N-acetylglucosaminidase (NAGLU) LDTP04634 33.59  LDD2024 
Apoptosis-inducing factor 1, mitochondrial (AIFM1) LDTP01687 39.40  LDD2024 
Atlastin-2 (ATL2) LDTP09251 16.56  LDD2024 
ATPase family AAA domain-containing protein 3A (ATAD3A) LDTP12681 19.56  LDD2024 
Beta-glucuronidase (GUSB) LDTP02260 17.27  LDD2024 
Beta-hexosaminidase subunit alpha (HEXA) LDTP02169 22.47  LDD2024 
Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) LDTP01241 21.56  LDD2024 
CAAX prenyl protease 1 homolog (ZMPSTE24) LDTP01328 24.42  LDD2024 
Carbohydrate sulfotransferase 14 (CHST14) LDTP09096 38.59  LDD2024 
Cartilage-associated protein (CRTAP) LDTP01300 16.34  LDD2024 
Casein kinase I isoform alpha (CSNK1A1) LDTP04209 17.27  LDD2024 
Catechol O-methyltransferase (COMT) LDTP03145 37.01  LDD2024 
Cathepsin B (CTSB) LDTP02223 34.78  LDD2024 
CCR4-NOT transcription complex subunit 4 (CNOT4) LDTP01640 22.94  LDD2024 
CDGSH iron-sulfur domain-containing protein 1 (CISD1) LDTP12873 28.84  LDD2024 
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial (PGS1) LDTP06749 19.56  LDD2024 
Ceramide glucosyltransferase (UGCG) LDTP06617 25.11  LDD2024 
Ceramide synthase 2 (CERS2) LDTP10329 39.40  LDD2024 
Choline kinase alpha (CHKA) LDTP03787 17.75  LDD2024 
COP9 signalosome complex subunit 4 (COPS4) LDTP11187 18.64  LDD2024 
COP9 signalosome complex subunit 6 (COPS6) LDTP07966 16.00  LDD2024 
Cytochrome b-c1 complex subunit 2, mitochondrial (UQCRC2) LDTP03189 19.03  LDD2024 
Cytochrome b5 type B (CYB5B) LDTP00697 67.18  LDD2024 
Cytochrome c oxidase subunit 2 (MT-CO2) LDTP01773 20.39  LDD2024 
Cytosolic 5'-nucleotidase 3A (NT5C3A) LDTP11723 32.00  LDD2024 
DCN1-like protein 4 (DCUN1D4) LDTP09799 73.01  LDD2024 
Dehydrogenase/reductase SDR family member 1 (DHRS1) LDTP10550 15.78  LDD2024 
Delta(24)-sterol reductase (DHCR24) LDTP06375 17.27  LDD2024 
Dephospho-CoA kinase domain-containing protein (DCAKD) LDTP18087 17.27  LDD2024 
DNA replication licensing factor MCM6 (MCM6) LDTP06150 20.97  LDD2024 
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (STT3A) LDTP04120 16.45  LDD2024 
Dual specificity protein phosphatase 9 (DUSP9) LDTP11016 16.45  LDD2024 
E3 ubiquitin-protein ligase NEDD4-like (NEDD4L) LDTP10699 19.16  LDD2024 
Endoplasmic reticulum aminopeptidase 1 (ERAP1) LDTP12868 21.56  LDD2024 
Endoplasmic reticulum protein SC65 (P3H4) LDTP09874 18.13  LDD2024 
Endoplasmic reticulum transmembrane helix translocase (ATP13A1) LDTP12279 19.84  LDD2024 
Endothelin-converting enzyme 1 (ECE1) LDTP04008 31.34  LDD2024 
Epoxide hydrolase 1 (EPHX1) LDTP02175 30.27  LDD2024 
Ethanolamine kinase 1 (ETNK1) LDTP12197 43.11  LDD2024 
FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1) LDTP10188 21.26  LDD2024 
Ferrochelatase, mitochondrial (FECH) LDTP03198 42.81  LDD2024 
Glutathione hydrolase 7 (GGT7) LDTP13367 16.80  LDD2024 
Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM) LDTP12253 38.85  LDD2024 
Glycosyltransferase 8 domain-containing protein 1 (GLT8D1) LDTP17305 24.93  LDD2024 
Heme oxygenase 1 (HMOX1) LDTP02359 40.22  LDD2024 
Heme oxygenase 2 (HMOX2) LDTP03540 67.18  LDD2024 
Heparan sulfate 2-O-sulfotransferase 1 (HS2ST1) LDTP07990 19.03  LDD2024 
Histone-lysine N-methyltransferase NSD2 (NSD2) LDTP01759 16.45  LDD2024 
Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) LDTP06787 24.93  LDD2024 
Ketosamine-3-kinase (FN3KRP) LDTP16025 16.45  LDD2024 
Lanosterol 14-alpha demethylase (CYP51A1) LDTP06648 39.40  LDD2024 
Leucyl-cystinyl aminopeptidase (LNPEP) LDTP13358 16.11  LDD2024 
Lipid droplet-associated hydrolase (LDAH) LDTP16007 20.97  LDD2024 
Lysophosphatidic acid phosphatase type 6 (ACP6) LDTP12363 68.12  LDD2024 
Lysophospholipid acyltransferase 7 (MBOAT7) LDTP10612 15.56  LDD2024 
Lysosomal acid glucosylceramidase (GBA1) LDTP02005 21.41  LDD2024 
Lysosomal acid phosphatase (ACP2) LDTP02539 21.86  LDD2024 
Lysosomal alpha-glucosidase (GAA) LDTP02486 32.45  LDD2024 
Lysosomal protective protein (CTSA) LDTP02505 32.00  LDD2024 
Lysosomal thioesterase PPT2 (PPT2) LDTP13620 34.78  LDD2024 
Macrophage migration inhibitory factor (MIF) LDTP02713 43.71  LDD2024 
Methylsterol monooxygenase 1 (MSMO1) LDTP06477 17.27  LDD2024 
Mitotic checkpoint serine/threonine-protein kinase BUB1 (BUB1) LDTP00837 16.80  LDD2024 
N-acetylglucosamine-6-sulfatase (GNS) LDTP02799 19.03  LDD2024 
NAD-dependent protein deacetylase sirtuin-2 (SIRT2) LDTP08598 24.93  LDD2024 
NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) LDTP00832 46.53  LDD2024 
NADH dehydrogenase 1 beta subcomplex subunit 5, mitochondrial (NDUFB5) LDTP00831 18.64  LDD2024 
NADH dehydrogenase 1 beta subcomplex subunit 6 (NDUFB6) LDTP01502 19.84  LDD2024 
NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) LDTP01982 53.08  LDD2024 
Nicotinamide phosphoribosyltransferase (NAMPT) LDTP04051 15.67  LDD2024 
Palmitoyl-protein thioesterase 1 (PPT1) LDTP04388 99.73  LDD2024 
Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) LDTP12628 16.80  LDD2024 
Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) LDTP12720 16.56  LDD2024 
Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) LDTP14218 29.04  LDD2024 
Peptidyl-prolyl cis-trans isomerase FKBP9 (FKBP9) LDTP01562 23.75  LDD2024 
Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1) LDTP06307 19.84  LDD2024 
Phenylalanine--tRNA ligase beta subunit (FARSB) LDTP12586 52.71  LDD2024 
Phospholipase A-2-activating protein (PLAA) LDTP13814 19.70  LDD2024 
Phospholipase A2 group XV (PLA2G15) LDTP09088 16.11  LDD2024 
Prenylcysteine oxidase 1 (PCYOX1) LDTP13282 19.97  LDD2024 
Prenylcysteine oxidase-like (PCYOX1L) LDTP15480 15.67  LDD2024 
Probable serine carboxypeptidase CPVL (CPVL) LDTP15988 19.43  LDD2024 
Procathepsin L (CTSL) LDTP02217 22.63  LDD2024 
Prolyl 3-hydroxylase 1 (P3H1) LDTP06750 17.03  LDD2024 
Prolyl 4-hydroxylase subunit alpha-1 (P4HA1) LDTP02679 20.39  LDD2024 
Proteasome subunit beta type-1 (PSMB1) LDTP03060 33.82  LDD2024 
Proteasome subunit beta type-2 (PSMB2) LDTP04285 18.51  LDD2024 
Protein arginine N-methyltransferase 9 (PRMT9) LDTP07525 17.27  LDD2024 
Protein SCO1 homolog, mitochondrial (SCO1) LDTP01335 32.45  LDD2024 
Protein-S-isoprenylcysteine O-methyltransferase (ICMT) LDTP01039 39.12  LDD2024 
Putative phospholipase B-like 2 (PLBD2) LDTP09256 29.24  LDD2024 
RAC-beta serine/threonine-protein kinase (AKT2) LDTP03608 17.75  LDD2024 
Ras-related protein Rab-10 (RAB10) LDTP04895 22.01  LDD2024 
Retinoid-inducible serine carboxypeptidase (SCPEP1) LDTP16032 37.79  LDD2024 
RNA cytosine C(5)-methyltransferase NSUN2 (NSUN2) LDTP05588 23.92  LDD2024 
S-methyl-5'-thioadenosine phosphorylase (MTAP) LDTP05758 32.00  LDD2024 
Serum paraoxonase/arylesterase 2 (PON2) LDTP06333 51.63  LDD2024 
Signal peptidase complex catalytic subunit SEC11A (SEC11A) LDTP05066 33.82  LDD2024 
sn-1-specific diacylglycerol lipase ABHD11 (ABHD11) LDTP09225 19.70  LDD2024 
Sphingomyelin phosphodiesterase (SMPD1) LDTP02896 18.00  LDD2024 
Sphingosine-1-phosphate lyase 1 (SGPL1) LDTP01613 21.71  LDD2024 
Sterol O-acyltransferase 1 (SOAT1) LDTP03769 15.45  LDD2024 
Translin (TSN) LDTP06427 30.91  LDD2024 
Tripeptidyl-peptidase 1 (TPP1) LDTP00428 20.97  LDD2024 
Ubiquitin carboxyl-terminal hydrolase 47 (USP47) LDTP10495 19.16  LDD2024 
Ubiquitin carboxyl-terminal hydrolase 7 (USP7) LDTP09962 17.75  LDD2024 
UDP-glucuronic acid decarboxylase 1 (UXS1) LDTP09074 18.13  LDD2024 
V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) LDTP14030 22.16  LDD2024 
Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) LDTP06901 20.68  LDD2024 
Vesicle transport protein GOT1B (GOLT1B) LDTP13986 15.45  LDD2024 
Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) LDTP08728 41.93  LDD2024 
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⏷ Show the Full List of 123 Enzyme
88 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
45 kDa calcium-binding protein (SDF4) LDTP11116 23.75  LDD2024 
Acetyl-coenzyme A transporter 1 (SLC33A1) LDTP00262 52.71  LDD2024 
Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) LDTP09328 28.05  LDD2024 
Amyloid-beta precursor protein (APP) LDTP02071 17.39  LDD2024 
ATP synthase F(0) complex subunit B1, mitochondrial (ATP5PB) LDTP03284 16.00  LDD2024 
ATP synthase subunit a (MT-ATP6) LDTP01804 95.67  LDD2024 
ATP synthase subunit g, mitochondrial (ATP5MG) LDTP14511 39.67  LDD2024 
Autophagy-related protein 9A (ATG9A) LDTP08030 16.34  LDD2024 
B-cell receptor-associated protein 31 (BCAP31) LDTP04426 16.91  LDD2024 
BRI3-binding protein (BRI3BP) LDTP15648 19.43  LDD2024 
Cation-dependent mannose-6-phosphate receptor (M6PR) LDTP03061 18.38  LDD2024 
Cytochrome c oxidase assembly protein COX18, mitochondrial (COX18) LDTP08981 26.54  LDD2024 
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1) LDTP02645 16.91  LDD2024 
Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) LDTP02724 30.91  LDD2024 
Cytoskeleton-associated protein 4 (CKAP4) LDTP05511 31.34  LDD2024 
Derlin-1 (DERL1) LDTP11245 32.45  LDD2024 
ER lumen protein-retaining receptor 1 (KDELR1) LDTP03277 44.94  LDD2024 
ER membrane protein complex subunit 5 (MMGT1) LDTP08878 66.72  LDD2024 
Golgi SNAP receptor complex member 1 (GOSR1) LDTP01542 24.42  LDD2024 
Golgin subfamily A member 5 (GOLGA5) LDTP09333 33.36  LDD2024 
Growth hormone-inducible transmembrane protein (GHITM) LDTP11869 45.25  LDD2024 
Guided entry of tail-anchored proteins factor CAMLG (CAMLG) LDTP04227 24.59  LDD2024 
High affinity cationic amino acid transporter 1 (SLC7A1) LDTP03559 24.08  LDD2024 
Integral membrane protein 2C (ITM2C) LDTP12451 22.94  LDD2024 
Lipid scramblase CLPTM1L (CLPTM1L) LDTP10499 22.16  LDD2024 
Lysosomal-associated transmembrane protein 4A (LAPTM4A) LDTP06275 99.73  LDD2024 
Lysosome membrane protein 2 (SCARB2) LDTP06034 49.18  LDD2024 
Lysosome-associated membrane glycoprotein 1 (LAMP1) LDTP02562 41.93  LDD2024 
Melanoma inhibitory activity protein 2 (MIA2) LDTP10669 65.80  LDD2024 
Membrane-associated progesterone receptor component 1 (PGRMC1) LDTP00235 52.71  LDD2024 
Membrane-associated progesterone receptor component 2 (PGRMC2) LDTP00562 99.73  LDD2024 
Metaxin-1 (MTX1) LDTP05900 35.75  LDD2024 
Mitochondrial adenyl nucleotide antiporter SLC25A24 (SLC25A24) LDTP07472 19.43  LDD2024 
Mitochondrial adenyl nucleotide antiporter SLC25A25 (SLC25A25) LDTP07439 16.34  LDD2024 
Mitochondrial dicarboxylate carrier (SLC25A10) LDTP13174 34.54  LDD2024 
Mitochondrial import inner membrane translocase subunit Tim10 (TIMM10) LDTP04956 33.13  LDD2024 
Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) LDTP13983 54.95  LDD2024 
Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) LDTP10913 38.32  LDD2024 
Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) LDTP01059 60.97  LDD2024 
Mitochondrial import inner membrane translocase subunit Tim22 (TIMM22) LDTP14099 46.53  LDD2024 
Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23) LDTP00477 16.91  LDD2024 
Mitochondrial inner membrane protein OXA1L (OXA1L) LDTP06308 24.76  LDD2024 
Mitochondrial ornithine transporter 1 (SLC25A15) LDTP14200 21.56  LDD2024 
Mitochondrial proton/calcium exchanger protein (LETM1) LDTP01525 20.82  LDD2024 
Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) LDTP07885 23.43  LDD2024 
Mitochondrial thiamine pyrophosphate carrier (SLC25A19) LDTP12210 15.45  LDD2024 
Mpv17-like protein 2 (MPV17L2) LDTP14952 15.56  LDD2024 
NPC intracellular cholesterol transporter 1 (NPC1) LDTP00541 21.71  LDD2024 
NPC intracellular cholesterol transporter 2 (NPC2) LDTP04940 16.91  LDD2024 
Nuclear pore complex protein Nup88 (NUP88) LDTP10897 16.00  LDD2024 
PAT complex subunit CCDC47 (CCDC47) LDTP10059 21.71  LDD2024 
Peroxisomal membrane protein PMP34 (SLC25A17) LDTP00872 30.06  LDD2024 
Prenylated Rab acceptor protein 1 (RABAC1) LDTP13320 20.82  LDD2024 
Prosaposin (PSAP) LDTP02215 54.95  LDD2024 
Protein GPR107 (GPR107) LDTP07236 30.27  LDD2024 
Protein GPR108 (GPR108) LDTP12383 32.90  LDD2024 
Protein spinster homolog 1 (SPNS1) LDTP11844 48.84  LDD2024 
Protein tweety homolog 3 (TTYH3) LDTP11615 20.97  LDD2024 
Protein YIPF3 (YIPF3) LDTP11626 20.39  LDD2024 
Putative divalent cation/proton antiporter TMEM165 (TMEM165) LDTP12207 47.84  LDD2024 
Rhomboid domain-containing protein 2 (RHBDD2) LDTP07467 16.91  LDD2024 
Scavenger receptor class B member 1 (SCARB1) LDTP09547 20.39  LDD2024 
Secretory carrier-associated membrane protein 2 (SCAMP2) LDTP00547 23.10  LDD2024 
Sideroflexin-4 (SFXN4) LDTP07531 18.90  LDD2024 
Sigma intracellular receptor 2 (TMEM97) LDTP06945 22.47  LDD2024 
Solute carrier family 25 member 32 (SLC25A32) LDTP11813 20.11  LDD2024 
Solute carrier family 25 member 33 (SLC25A33) LDTP11162 54.57  LDD2024 
StAR-related lipid transfer protein 7, mitochondrial (STARD7) LDTP18459 17.88  LDD2024 
STARD3 N-terminal-like protein (STARD3NL) LDTP01671 40.50  LDD2024 
Stomatin (STOM) LDTP03380 22.94  LDD2024 
Synaptojanin-2-binding protein (SYNJ2BP) LDTP04789 18.77  LDD2024 
Syntaxin-6 (STX6) LDTP00857 20.97  LDD2024 
Tetraspanin-3 (TSPAN3) LDTP16813 70.52  LDD2024 
Translocating chain-associated membrane protein 1 (TRAM1) LDTP06426 51.63  LDD2024 
Translocon-associated protein subunit alpha (SSR1) LDTP04033 33.13  LDD2024 
Transmembrane 9 superfamily member 3 (TM9SF3) LDTP18448 19.70  LDD2024 
Transmembrane 9 superfamily member 4 (TM9SF4) LDTP09789 17.63  LDD2024 
Transmembrane emp24 domain-containing protein 2 (TMED2) LDTP06365 41.07  LDD2024 
Transmembrane protein 126A (TMEM126A) LDTP15948 77.71  LDD2024 
Transmembrane protein 160 (TMEM160) LDTP20002 38.32  LDD2024 
Transmembrane protein 199 (TMEM199) LDTP08881 28.44  LDD2024 
Transmembrane protein 214 (TMEM214) LDTP07477 17.51  LDD2024 
Transmembrane protein 230 (TMEM230) LDTP10065 24.25  LDD2024 
Transmembrane protein 87A (TMEM87A) LDTP15481 22.63  LDD2024 
V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) LDTP09968 32.00  LDD2024 
Voltage-dependent anion-selective channel protein 1 (VDAC1) LDTP03132 38.59  LDD2024 
Voltage-dependent anion-selective channel protein 2 (VDAC2) LDTP04071 31.12  LDD2024 
Voltage-dependent anion-selective channel protein 3 (VDAC3) LDTP13824 21.41  LDD2024 
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⏷ Show the Full List of 88 Transporter and channel
1 Transcription factor Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
DnaJ homolog subfamily C member 1 (DNAJC1) LDTP10501 20.11  LDD2024 
------------------------------------------------------------------------------------
105 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
60S ribosomal export protein NMD3 (NMD3) LDTP10200 16.80  LDD2024 
Adenomatous polyposis coli protein (APC) LDTP03303 16.45  LDD2024 
ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL6IP1) LDTP06291 25.11  LDD2024 
Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) LDTP08364 16.45  LDD2024 
Apolipoprotein L2 (APOL2) LDTP11076 99.73  LDD2024 
Arfaptin-2 (ARFIP2) LDTP04557 19.43  LDD2024 
BAG family molecular chaperone regulator 4 (BAG4) LDTP01600 15.45  LDD2024 
Bombesin receptor-activated protein C6orf89 (C6orf89) LDTP07681 20.97  LDD2024 
Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) LDTP13755 19.43  LDD2024 
Calumenin (CALU) LDTP00887 16.56  LDD2024 
Centrin-2 (CETN2) LDTP03926 17.75  LDD2024 
Centrosomal protein 43 (CEP43) LDTP01652 19.84  LDD2024 
Clustered mitochondria protein homolog (CLUH) LDTP14486 18.51  LDD2024 
Collectin-12 (COLEC12) LDTP07031 17.39  LDD2024 
Complex I assembly factor TIMMDC1, mitochondrial (TIMMDC1) LDTP12379 20.25  LDD2024 
COP9 signalosome complex subunit 8 (COPS8) LDTP10927 15.67  LDD2024 
CYFIP-related Rac1 interactor B (CYRIB) LDTP12642 26.35  LDD2024 
Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) LDTP13902 99.73  LDD2024 
DDRGK domain-containing protein 1 (DDRGK1) LDTP10403 27.28  LDD2024 
Diablo IAP-binding mitochondrial protein (DIABLO) LDTP12468 25.28  LDD2024 
Dynactin subunit 3 (DCTN3) LDTP01359 20.68  LDD2024 
EF-hand calcium-binding domain-containing protein 14 (EFCAB14) LDTP19021 36.50  LDD2024 
Emerin (EMD) LDTP04356 16.56  LDD2024 
Endoplasmic reticulum-Golgi intermediate compartment protein 1 (ERGIC1) LDTP10046 19.84  LDD2024 
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) LDTP13828 35.75  LDD2024 
ER lumen protein-retaining receptor 2 (KDELR2) LDTP03678 37.27  LDD2024 
ER lumen protein-retaining receptor 3 (KDELR3) LDTP00850 23.59  LDD2024 
Eukaryotic translation initiation factor 5 (EIF5) LDTP04652 18.90  LDD2024 
FUN14 domain-containing protein 2 (FUNDC2) LDTP11326 25.63  LDD2024 
Galectin-3-binding protein (LGALS3BP) LDTP05558 16.00  LDD2024 
Ganglioside GM2 activator (GM2A) LDTP02927 18.25  LDD2024 
Golgi integral membrane protein 4 (GOLIM4) LDTP00281 16.00  LDD2024 
Golgi phosphoprotein 3 (GOLPH3) LDTP11911 21.56  LDD2024 
HAUS augmin-like complex subunit 1 (HAUS1) LDTP10184 18.90  LDD2024 
HAUS augmin-like complex subunit 4 (HAUS4) LDTP11978 15.89  LDD2024 
HAUS augmin-like complex subunit 5 (HAUS5) LDTP01466 16.68  LDD2024 
HCLS1-associated protein X-1 (HAX1) LDTP00199 15.67  LDD2024 
Heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2) LDTP04714 15.67  LDD2024 
Immunoglobulin-binding protein 1 (IGBP1) LDTP05089 16.56  LDD2024 
Inhibitor of nuclear factor kappa-B kinase-interacting protein (IKBIP) LDTP07891 39.95  LDD2024 
Keratin, type I cytoskeletal 18 (KRT18) LDTP02124 25.11  LDD2024 
Keratinocyte-associated transmembrane protein 2 (KCT2) LDTP19780 15.67  LDD2024 
Kinetochore protein Spc24 (SPC24) LDTP09069 22.63  LDD2024 
Lamina-associated polypeptide 2, isoforms beta/gamma (TMPO) LDTP03968 21.56  LDD2024 
Large proline-rich protein BAG6 (BAG6) LDTP04094 19.03  LDD2024 
Large ribosomal subunit protein mL55 (MRPL55) LDTP15269 91.14  LDD2024 
Large ribosomal subunit protein uL10m (MRPL10) LDTP08154 19.56  LDD2024 
LYR motif-containing protein 2 (LYRM2) LDTP18467 39.12  LDD2024 
Mediator of RNA polymerase II transcription subunit 25 (MED25) LDTP07906 41.64  LDD2024 
Microtubule nucleation factor SSNA1 (SSNA1) LDTP00871 20.11  LDD2024 
Mitochondrial fission process protein 1 (MTFP1) LDTP16192 33.82  LDD2024 
Mitochondrial fission regulator 2 (MTFR2) LDTP15112 17.51  LDD2024 
Mitochondrial import receptor subunit TOM22 homolog (TOMM22) LDTP12565 63.56  LDD2024 
Neurofilament light polypeptide (NEFL) LDTP02180 18.13  LDD2024 
Nicastrin (NCSTN) LDTP09787 18.25  LDD2024 
Nucleobindin-1 (NUCB1) LDTP05375 18.51  LDD2024 
Nucleobindin-2 (NUCB2) LDTP05160 63.12  LDD2024 
Nucleosome assembly protein 1-like 4 (NAP1L4) LDTP10965 17.88  LDD2024 
Nurim (NRM) LDTP08606 23.10  LDD2024 
OCIA domain-containing protein 1 (OCIAD1) LDTP12755 18.64  LDD2024 
Optic atrophy 3 protein (OPA3) LDTP16006 57.68  LDD2024 
Phosducin-like protein 3 (PDCL3) LDTP11825 23.75  LDD2024 
Poly(U)-binding-splicing factor PUF60 (PUF60) LDTP13311 47.50  LDD2024 
Polyadenylate-binding protein-interacting protein 2 (PAIP2) LDTP11044 21.41  LDD2024 
Proteasome activator complex subunit 2 (PSME2) LDTP13519 16.11  LDD2024 
Proteasome activator complex subunit 3 (PSME3) LDTP04917 25.63  LDD2024 
Protein ecdysoneless homolog (ECD) LDTP01711 16.11  LDD2024 
Protein FAM114A2 (FAM114A2) LDTP16080 22.94  LDD2024 
Protein FAM162A (FAM162A) LDTP10056 50.91  LDD2024 
Protein Hook homolog 2 (HOOK2) LDTP10255 27.47  LDD2024 
Protein jagunal homolog 1 (JAGN1) LDTP08904 16.91  LDD2024 
Protein PALS2 (PALS2) LDTP16156 17.51  LDD2024 
Protein unc-119 homolog A (UNC119) LDTP05868 20.11  LDD2024 
Protein unc-119 homolog B (UNC119B) LDTP00105 15.56  LDD2024 
Protein YIF1A (YIF1A) LDTP01494 15.45  LDD2024 
Ran guanine nucleotide release factor (RANGRF) LDTP12287 18.00  LDD2024 
Receptor expression-enhancing protein 4 (REEP4) LDTP11981 15.67  LDD2024 
Reticulocalbin-2 (RCN2) LDTP06097 18.51  LDD2024 
Reticulon-3 (RTN3) LDTP01522 43.71  LDD2024 
Reticulon-4 (RTN4) LDTP12412 45.57  LDD2024 
RNA-binding protein 10 (RBM10) LDTP05224 15.78  LDD2024 
RNA-binding protein 3 (RBM3) LDTP05226 20.68  LDD2024 
RNA-binding protein 5 (RBM5) LDTP04527 16.68  LDD2024 
RNA-binding protein EWS (EWSR1) LDTP05318 16.34  LDD2024 
RNA-binding protein FUS (FUS) LDTP03775 19.43  LDD2024 
Signal recognition particle receptor subunit beta (SRPRB) LDTP16323 25.46  LDD2024 
Small ribosomal subunit protein uS9m (MRPS9) LDTP14792 18.25  LDD2024 
Synaptogyrin-2 (SYNGR2) LDTP00859 17.03  LDD2024 
Syntaxin-10 (STX10) LDTP00986 31.34  LDD2024 
Syntaxin-18 (STX18) LDTP13086 86.82  LDD2024 
TATA-binding protein-associated factor 2N (TAF15) LDTP09881 16.68  LDD2024 
Tetratricopeptide repeat protein 19, mitochondrial (TTC19) LDTP07368 22.47  LDD2024 
Thioredoxin domain-containing protein 15 (TXNDC15) LDTP10442 18.00  LDD2024 
Thioredoxin-related transmembrane protein 4 (TMX4) LDTP18373 25.63  LDD2024 
TraB domain-containing protein (TRABD) LDTP19963 26.72  LDD2024 
Trophoblast glycoprotein (TPBG) LDTP05960 24.76  LDD2024 
Tubulin beta chain (TUBB) LDTP02205 18.13  LDD2024 
Tubulin beta-2A chain (TUBB2A) LDTP05998 16.00  LDD2024 
Tubulin beta-4A chain (TUBB4A) LDTP02037 17.15  LDD2024 
Tubulin beta-4B chain (TUBB4B) LDTP05076 17.15  LDD2024 
Tudor and KH domain-containing protein (TDRKH) LDTP13922 23.92  LDD2024 
Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) LDTP15067 57.28  LDD2024 
Vesicle transport protein SEC20 (BNIP1) LDTP05715 16.45  LDD2024 
Vimentin (VIM) LDTP02297 25.11  LDD2024 
Zinc finger CCHC domain-containing protein 3 (ZCCHC3) LDTP12623 24.25  LDD2024 
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Full Information of The Labelling Profiles of This Probe

Quantification: AfBPP Probe vs Negative Probe
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
Probe:50uM; negative probe:50uM
Quantitative Method
TMT
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Peripheral blood
Disease Model
Normal
Model Name
Human normal cells (HEK-293T)
Note
Negative probe:C#CCCC1(CCC(NC)=O)N=N1
Interaction Atlas ID
 LDD2024 
Download The Altas

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587