Details of the Target

General Information of Target

Target ID LDTP13358
Target Name Leucyl-cystinyl aminopeptidase (LNPEP)
Gene Name LNPEP
Gene ID 4012
Synonyms
OTASE; Leucyl-cystinyl aminopeptidase; Cystinyl aminopeptidase; EC 3.4.11.3; Insulin-regulated membrane aminopeptidase; Insulin-responsive aminopeptidase; IRAP; Oxytocinase; OTase; Placental leucine aminopeptidase; P-LAP) [Cleaved into: Leucyl-cystinyl aminopeptidase, pregnancy serum form]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAQASPPRPERVLGASSPEARPAQEALLLPTGVFQVAEKMEKRTCALCPKDVEYNVLYFA
QSENIAAHENCLLYSSGLVECEDQDPLNPDRSFDVESVKKEIQRGRKLKCKFCHKRGATV
GCDLKNCNKNYHFFCAKKDDAVPQSDGVRGIYKLLCQQHAQFPIIAQSAKFSGVKRKRGR
KKPLSGNHVQPPETMKCNTFIRQVKEEHGRHTDATVKVPFLKKCKEAGLLNYLLEEILDK
VHSIPEKLMDETTSESDYEEIGSALFDCRLFEDTFVNFQAAIEKKIHASQQRWQQLKEEI
ELLQDLKQTLCSFQENRDLMSSSTSISSLSY
Target Type
Patented-recorded
Target Bioclass
Enzyme
Family
Peptidase M1 family
Subcellular location
Secreted; Cell membrane
Function
Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain.
TTD ID
T97537
Uniprot ID
Q9UIQ6
DrugMap ID
TTY2KP7
Ensemble ID
ENST00000231368.10
HGNC ID
HGNC:6656
ChEMBL ID
CHEMBL2693

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA Deletion: p.N145TfsTer6 DBIA    Probe Info 
DU145 SNV: p.V225I DBIA    Probe Info 
HCC1954 SNV: p.M493V DBIA    Probe Info 
HCT15 SNV: p.Y46H DBIA    Probe Info 
KURAMOCHI SNV: p.S450Y DBIA    Probe Info 
KYSE410 SNV: p.K318Q DBIA    Probe Info 
LNCaP clone FGC SNV: p.I963M DBIA    Probe Info 
MEWO Substitution: p.R109K .
MFE319 SNV: p.G742D DBIA    Probe Info 
NCIH2052 SNV: p.K521N DBIA    Probe Info 
NCIH23 SNV: p.G273W DBIA    Probe Info 
SW1271 SNV: p.A164S DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.03  LDD0402  [1]
FBPP2
 Probe Info  		13.19  LDD0318  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
OPA-S-S-alkyne
 Probe Info  		K626(0.72); K624(0.72); K726(0.91); K923(5.14)  LDD3494  [4]
AHL-Pu-1
 Probe Info  		C35(2.05)  LDD0168  [5]
DBIA
 Probe Info  		C103(1.11)  LDD0078  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		C305(0.00); C35(0.00)  LDD0037  [7]
NAIA_5
 Probe Info  		N.A.  LDD2224  [8]
TFBX
 Probe Info  		N.A.  LDD0027  [9]
WYneO
 Probe Info  		N.A.  LDD0022  [10]
Compound 10
 Probe Info  		N.A.  LDD2216  [11]
Compound 11
 Probe Info  		N.A.  LDD2213  [11]
IPM
 Probe Info  		N.A.  LDD0147  [9]
PF-06672131
 Probe Info  		N.A.  LDD0017  [12]
Acrolein
 Probe Info  		C35(0.00); C305(0.00)  LDD0217  [13]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [13]
Methacrolein
 Probe Info  		C305(0.00); C35(0.00)  LDD0218  [13]
PAL-AfBPP Probe
Click To Hide/Show 152 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C001
 Probe Info  		12.30  LDD1711  [14]
C004
 Probe Info  		7.73  LDD1714  [14]
C018
 Probe Info  		5.86  LDD1726  [14]
C036
 Probe Info  		8.22  LDD1736  [14]
C039
 Probe Info  		6.96  LDD1739  [14]
C040
 Probe Info  		18.51  LDD1740  [14]
C041
 Probe Info  		9.85  LDD1741  [14]
C044
 Probe Info  		6.68  LDD1743  [14]
C045
 Probe Info  		12.73  LDD1744  [14]
C059
 Probe Info  		5.17  LDD1756  [14]
C060
 Probe Info  		8.51  LDD1757  [14]
C063
 Probe Info  		12.82  LDD1760  [14]
C070
 Probe Info  		9.65  LDD1766  [14]
C073
 Probe Info  		12.21  LDD1769  [14]
C082
 Probe Info  		12.04  LDD1774  [14]
C085
 Probe Info  		13.93  LDD1777  [14]
C087
 Probe Info  		14.03  LDD1779  [14]
C089
 Probe Info  		8.06  LDD1781  [14]
C091
 Probe Info  		11.39  LDD1782  [14]
C092
 Probe Info  		16.68  LDD1783  [14]
C095
 Probe Info  		4.96  LDD1786  [14]
C106
 Probe Info  		19.70  LDD1793  [14]
C107
 Probe Info  		8.11  LDD1794  [14]
C108
 Probe Info  		14.03  LDD1795  [14]
C112
 Probe Info  		18.13  LDD1799  [14]
C115
 Probe Info  		12.73  LDD1802  [14]
C117
 Probe Info  		9.58  LDD1804  [14]
C130
 Probe Info  		7.41  LDD1812  [14]
C139
 Probe Info  		13.27  LDD1821  [14]
C140
 Probe Info  		11.96  LDD1822  [14]
C141
 Probe Info  		15.35  LDD1823  [14]
C145
 Probe Info  		15.14  LDD1827  [14]
C147
 Probe Info  		7.78  LDD1829  [14]
C149
 Probe Info  		16.34  LDD1830  [14]
C153
 Probe Info  		18.13  LDD1834  [14]
C159
 Probe Info  		16.68  LDD1839  [14]
C160
 Probe Info  		17.63  LDD1840  [14]
C161
 Probe Info  		15.14  LDD1841  [14]
C164
 Probe Info  		11.96  LDD1844  [14]
C166
 Probe Info  		6.82  LDD1846  [14]
C170
 Probe Info  		33.59  LDD1850  [14]
C171
 Probe Info  		8.82  LDD1851  [14]
C177
 Probe Info  		7.67  LDD1856  [14]
C178
 Probe Info  		18.00  LDD1857  [14]
C182
 Probe Info  		7.06  LDD1860  [14]
C183
 Probe Info  		8.00  LDD1861  [14]
C186
 Probe Info  		28.05  LDD1864  [14]
C187
 Probe Info  		19.56  LDD1865  [14]
C191
 Probe Info  		12.30  LDD1868  [14]
C193
 Probe Info  		8.06  LDD1869  [14]
C197
 Probe Info  		8.46  LDD1873  [14]
C201
 Probe Info  		29.04  LDD1877  [14]
C206
 Probe Info  		18.90  LDD1881  [14]
C208
 Probe Info  		19.97  LDD1883  [14]
C211
 Probe Info  		15.45  LDD1885  [14]
C212
 Probe Info  		5.54  LDD1886  [14]
C213
 Probe Info  		14.52  LDD1887  [14]
C215
 Probe Info  		4.96  LDD1889  [14]
C216
 Probe Info  		8.11  LDD1890  [14]
C218
 Probe Info  		16.00  LDD1892  [14]
C219
 Probe Info  		14.62  LDD1893  [14]
C220
 Probe Info  		12.21  LDD1894  [14]
C221
 Probe Info  		10.34  LDD1895  [14]
C223
 Probe Info  		18.64  LDD1897  [14]
C225
 Probe Info  		8.00  LDD1898  [14]
C226
 Probe Info  		12.47  LDD1899  [14]
C228
 Probe Info  		25.46  LDD1901  [14]
C229
 Probe Info  		7.16  LDD1902  [14]
C231
 Probe Info  		28.84  LDD1904  [14]
C232
 Probe Info  		35.75  LDD1905  [14]
C233
 Probe Info  		17.63  LDD1906  [14]
C234
 Probe Info  		8.00  LDD1907  [14]
C237
 Probe Info  		13.74  LDD1910  [14]
C238
 Probe Info  		10.85  LDD1911  [14]
C239
 Probe Info  		5.66  LDD1912  [14]
C243
 Probe Info  		11.00  LDD1916  [14]
C249
 Probe Info  		17.03  LDD1922  [14]
C252
 Probe Info  		9.51  LDD1925  [14]
C260
 Probe Info  		4.96  LDD1932  [14]
C265
 Probe Info  		24.42  LDD1936  [14]
C270
 Probe Info  		6.96  LDD1940  [14]
C277
 Probe Info  		13.18  LDD1947  [14]
C280
 Probe Info  		11.08  LDD1950  [14]
C281
 Probe Info  		12.82  LDD1951  [14]
C282
 Probe Info  		16.34  LDD1952  [14]
C286
 Probe Info  		6.41  LDD1956  [14]
C288
 Probe Info  		7.41  LDD1958  [14]
C290
 Probe Info  		8.28  LDD1960  [14]
C293
 Probe Info  		19.70  LDD1963  [14]
C302
 Probe Info  		19.03  LDD1971  [14]
C303
 Probe Info  		8.46  LDD1972  [14]
C305
 Probe Info  		16.34  LDD1974  [14]
C310
 Probe Info  		16.80  LDD1977  [14]
C313
 Probe Info  		16.22  LDD1980  [14]
C314
 Probe Info  		13.74  LDD1981  [14]
C318
 Probe Info  		5.98  LDD1984  [14]
C320
 Probe Info  		6.68  LDD1986  [14]
C326
 Probe Info  		9.38  LDD1990  [14]
C333
 Probe Info  		5.90  LDD1996  [14]
C334
 Probe Info  		7.21  LDD1997  [14]
C336
 Probe Info  		6.11  LDD1999  [14]
C337
 Probe Info  		5.98  LDD2000  [14]
C338
 Probe Info  		11.96  LDD2001  [14]
C340
 Probe Info  		6.73  LDD2003  [14]
C342
 Probe Info  		12.30  LDD2004  [14]
C343
 Probe Info  		17.88  LDD2005  [14]
C346
 Probe Info  		19.70  LDD2007  [14]
C348
 Probe Info  		18.64  LDD2009  [14]
C349
 Probe Info  		27.28  LDD2010  [14]
C350
 Probe Info  		26.35  LDD2011  [14]
C353
 Probe Info  		22.01  LDD2014  [14]
C354
 Probe Info  		11.55  LDD2015  [14]
C355
 Probe Info  		37.79  LDD2016  [14]
C356
 Probe Info  		12.47  LDD2017  [14]
C357
 Probe Info  		6.45  LDD2018  [14]
C359
 Probe Info  		6.23  LDD2020  [14]
C360
 Probe Info  		5.94  LDD2021  [14]
C361
 Probe Info  		22.47  LDD2022  [14]
C363
 Probe Info  		16.11  LDD2024  [14]
C369
 Probe Info  		6.15  LDD2030  [14]
C374
 Probe Info  		5.54  LDD2034  [14]
C375
 Probe Info  		8.06  LDD2035  [14]
C376
 Probe Info  		7.31  LDD2036  [14]
C378
 Probe Info  		6.06  LDD2037  [14]
C380
 Probe Info  		11.31  LDD2039  [14]
C382
 Probe Info  		15.89  LDD2041  [14]
C383
 Probe Info  		11.63  LDD2042  [14]
C385
 Probe Info  		5.17  LDD2044  [14]
C386
 Probe Info  		9.51  LDD2045  [14]
C390
 Probe Info  		34.54  LDD2049  [14]
C391
 Probe Info  		25.63  LDD2050  [14]
C393
 Probe Info  		6.73  LDD2052  [14]
C403
 Probe Info  		18.25  LDD2061  [14]
C407
 Probe Info  		17.75  LDD2064  [14]
C420
 Probe Info  		20.39  LDD2075  [14]
C424
 Probe Info  		25.11  LDD2079  [14]
C425
 Probe Info  		18.51  LDD2080  [14]
C428
 Probe Info  		7.89  LDD2083  [14]
C429
 Probe Info  		21.71  LDD2084  [14]
C430
 Probe Info  		7.46  LDD2085  [14]
C433
 Probe Info  		9.51  LDD2088  [14]
FFF probe11
 Probe Info  		20.00  LDD0471  [15]
FFF probe12
 Probe Info  		20.00  LDD0473  [15]
FFF probe13
 Probe Info  		20.00  LDD0475  [15]
FFF probe14
 Probe Info  		20.00  LDD0477  [15]
FFF probe15
 Probe Info  		15.52  LDD0478  [15]
FFF probe3
 Probe Info  		14.66  LDD0480  [15]
FFF probe4
 Probe Info  		16.62  LDD0466  [15]
FFF probe9
 Probe Info  		20.00  LDD0470  [15]
JN0003
 Probe Info  		20.00  LDD0469  [15]
STS-2
 Probe Info  		N.A.  LDD0138  [16]
OEA-DA
 Probe Info  		20.00  LDD0046  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C35(2.05)  LDD0168  [5]
 LDCM0026  4SU-RNA+native RNA HEK-293T C35(2.28)  LDD0169  [5]
 LDCM0214  AC1 PaTu 8988t C305(0.86)  LDD1093  [6]
 LDCM0215  AC10 HEK-293T C305(0.98); C35(1.16)  LDD1508  [18]
 LDCM0216  AC100 HEK-293T C305(0.87)  LDD0814  [6]
 LDCM0217  AC101 HEK-293T C305(0.83)  LDD0815  [6]
 LDCM0218  AC102 HEK-293T C305(0.94)  LDD0816  [6]
 LDCM0219  AC103 HEK-293T C305(0.93)  LDD0817  [6]
 LDCM0220  AC104 HEK-293T C305(0.89)  LDD0818  [6]
 LDCM0221  AC105 HEK-293T C305(0.93)  LDD0819  [6]
 LDCM0222  AC106 HEK-293T C305(0.86)  LDD0820  [6]
 LDCM0223  AC107 HEK-293T C305(0.95)  LDD0821  [6]
 LDCM0224  AC108 HEK-293T C305(1.06)  LDD0822  [6]
 LDCM0225  AC109 HEK-293T C305(0.86)  LDD0823  [6]
 LDCM0226  AC11 HEK-293T C103(1.08); C305(0.93); C35(1.05)  LDD1509  [18]
 LDCM0227  AC110 HEK-293T C305(1.00)  LDD0825  [6]
 LDCM0228  AC111 HEK-293T C305(1.19)  LDD0826  [6]
 LDCM0229  AC112 HEK-293T C305(1.12)  LDD0827  [6]
 LDCM0230  AC113 HEK-293T C305(1.23)  LDD0828  [6]
 LDCM0231  AC114 HEK-293T C305(1.03)  LDD0829  [6]
 LDCM0232  AC115 HEK-293T C305(1.39)  LDD0830  [6]
 LDCM0233  AC116 HEK-293T C305(1.00)  LDD0831  [6]
 LDCM0234  AC117 HEK-293T C305(1.06)  LDD0832  [6]
 LDCM0235  AC118 HEK-293T C305(1.06)  LDD0833  [6]
 LDCM0236  AC119 HEK-293T C305(1.24)  LDD0834  [6]
 LDCM0237  AC12 HEK-293T C103(1.65); C305(1.05); C35(0.95)  LDD1510  [18]
 LDCM0238  AC120 HEK-293T C305(0.97)  LDD0836  [6]
 LDCM0239  AC121 HEK-293T C305(0.98)  LDD0837  [6]
 LDCM0240  AC122 HEK-293T C305(1.33)  LDD0838  [6]
 LDCM0241  AC123 HEK-293T C305(1.17)  LDD0839  [6]
 LDCM0242  AC124 HEK-293T C305(1.19)  LDD0840  [6]
 LDCM0243  AC125 HEK-293T C305(1.24)  LDD0841  [6]
 LDCM0244  AC126 HEK-293T C305(1.37)  LDD0842  [6]
 LDCM0245  AC127 HEK-293T C305(1.65)  LDD0843  [6]
 LDCM0246  AC128 HEK-293T C305(0.75)  LDD0844  [6]
 LDCM0247  AC129 HEK-293T C305(0.94)  LDD0845  [6]
 LDCM0249  AC130 HEK-293T C305(0.85)  LDD0847  [6]
 LDCM0250  AC131 HEK-293T C305(0.94)  LDD0848  [6]
 LDCM0251  AC132 HEK-293T C305(0.93)  LDD0849  [6]
 LDCM0252  AC133 HEK-293T C305(0.89)  LDD0850  [6]
 LDCM0253  AC134 HEK-293T C305(0.97)  LDD0851  [6]
 LDCM0254  AC135 HEK-293T C305(0.87)  LDD0852  [6]
 LDCM0255  AC136 HEK-293T C305(0.96)  LDD0853  [6]
 LDCM0256  AC137 HEK-293T C305(0.99)  LDD0854  [6]
 LDCM0257  AC138 HEK-293T C305(1.03)  LDD0855  [6]
 LDCM0258  AC139 HEK-293T C305(0.87)  LDD0856  [6]
 LDCM0259  AC14 HEK-293T C103(0.84); C305(0.95); C35(1.02)  LDD1512  [18]
 LDCM0260  AC140 HEK-293T C305(0.98)  LDD0858  [6]
 LDCM0261  AC141 HEK-293T C305(0.88)  LDD0859  [6]
 LDCM0262  AC142 HEK-293T C305(0.85)  LDD0860  [6]
 LDCM0263  AC143 HEK-293T C305(0.94)  LDD0861  [6]
 LDCM0264  AC144 HEK-293T C305(1.01)  LDD0862  [6]
 LDCM0265  AC145 HEK-293T C305(0.97)  LDD0863  [6]
 LDCM0266  AC146 HEK-293T C305(1.29)  LDD0864  [6]
 LDCM0267  AC147 HEK-293T C305(1.27)  LDD0865  [6]
 LDCM0268  AC148 HEK-293T C305(1.29)  LDD0866  [6]
 LDCM0269  AC149 HEK-293T C305(0.94)  LDD0867  [6]
 LDCM0270  AC15 HEK-293T C103(0.88); C305(1.00); C35(1.01)  LDD1513  [18]
 LDCM0271  AC150 HEK-293T C305(0.94)  LDD0869  [6]
 LDCM0272  AC151 HEK-293T C305(1.04)  LDD0870  [6]
 LDCM0273  AC152 HEK-293T C305(1.31)  LDD0871  [6]
 LDCM0274  AC153 HEK-293T C305(1.13)  LDD0872  [6]
 LDCM0621  AC154 HEK-293T C305(1.02)  LDD2162  [6]
 LDCM0622  AC155 HEK-293T C305(1.22)  LDD2163  [6]
 LDCM0623  AC156 HEK-293T C305(1.23)  LDD2164  [6]
 LDCM0624  AC157 HEK-293T C305(1.30)  LDD2165  [6]
 LDCM0276  AC17 HEK-293T C305(1.21)  LDD0874  [6]
 LDCM0277  AC18 HEK-293T C305(1.14)  LDD0875  [6]
 LDCM0278  AC19 HEK-293T C305(1.20)  LDD0876  [6]
 LDCM0279  AC2 PaTu 8988t C305(0.96)  LDD1158  [6]
 LDCM0280  AC20 HEK-293T C305(1.42)  LDD0878  [6]
 LDCM0281  AC21 HEK-293T C305(1.13)  LDD0879  [6]
 LDCM0282  AC22 HEK-293T C305(1.27)  LDD0880  [6]
 LDCM0283  AC23 HEK-293T C305(1.08)  LDD0881  [6]
 LDCM0284  AC24 HEK-293T C305(0.97)  LDD0882  [6]
 LDCM0285  AC25 PaTu 8988t C103(0.94)  LDD1164  [6]
 LDCM0286  AC26 PaTu 8988t C103(1.00)  LDD1165  [6]
 LDCM0287  AC27 PaTu 8988t C103(1.21)  LDD1166  [6]
 LDCM0288  AC28 PaTu 8988t C103(1.18)  LDD1167  [6]
 LDCM0289  AC29 PaTu 8988t C103(1.04)  LDD1168  [6]
 LDCM0290  AC3 PaTu 8988t C305(1.03)  LDD1169  [6]
 LDCM0291  AC30 PaTu 8988t C103(0.97)  LDD1170  [6]
 LDCM0292  AC31 PaTu 8988t C103(0.98)  LDD1171  [6]
 LDCM0293  AC32 PaTu 8988t C103(1.14)  LDD1172  [6]
 LDCM0294  AC33 PaTu 8988t C103(1.06)  LDD1173  [6]
 LDCM0295  AC34 PaTu 8988t C103(0.94)  LDD1174  [6]
 LDCM0296  AC35 HEK-293T C103(1.15); C305(0.98); C35(1.06)  LDD1535  [18]
 LDCM0297  AC36 HEK-293T C103(0.86); C305(1.00); C35(1.01)  LDD1536  [18]
 LDCM0298  AC37 HEK-293T C103(1.14); C305(0.90); C35(0.93)  LDD1537  [18]
 LDCM0299  AC38 HEK-293T C103(1.09); C305(0.99); C35(0.99)  LDD1538  [18]
 LDCM0300  AC39 HEK-293T C103(0.75); C305(1.01); C35(1.00)  LDD1539  [18]
 LDCM0301  AC4 PaTu 8988t C305(1.05)  LDD1180  [6]
 LDCM0302  AC40 HEK-293T C103(1.12); C305(0.96); C35(0.90)  LDD1541  [18]
 LDCM0303  AC41 HEK-293T C103(1.06); C305(1.02); C35(0.87)  LDD1542  [18]
 LDCM0304  AC42 HEK-293T C305(1.07); C35(1.06)  LDD1543  [18]
 LDCM0305  AC43 HEK-293T C103(0.83); C305(1.05); C35(0.97)  LDD1544  [18]
 LDCM0306  AC44 HEK-293T C103(0.89); C305(1.01); C35(1.02)  LDD1545  [18]
 LDCM0307  AC45 HEK-293T C103(1.25); C305(1.02); C35(1.09)  LDD1546  [18]
 LDCM0308  AC46 HEK-293T C305(1.00)  LDD0906  [6]
 LDCM0309  AC47 HEK-293T C305(0.85)  LDD0907  [6]
 LDCM0310  AC48 HEK-293T C305(0.85)  LDD0908  [6]
 LDCM0311  AC49 HEK-293T C305(0.91)  LDD0909  [6]
 LDCM0312  AC5 PaTu 8988t C305(0.93)  LDD1191  [6]
 LDCM0313  AC50 HEK-293T C305(1.01)  LDD0911  [6]
 LDCM0314  AC51 HEK-293T C305(0.88)  LDD0912  [6]
 LDCM0315  AC52 HEK-293T C305(0.90)  LDD0913  [6]
 LDCM0316  AC53 HEK-293T C305(1.21)  LDD0914  [6]
 LDCM0317  AC54 HEK-293T C305(0.94)  LDD0915  [6]
 LDCM0318  AC55 HEK-293T C305(1.00)  LDD0916  [6]
 LDCM0319  AC56 HEK-293T C305(0.96)  LDD0917  [6]
 LDCM0320  AC57 HEK-293T C305(0.91)  LDD0918  [6]
 LDCM0321  AC58 HEK-293T C305(1.08)  LDD0919  [6]
 LDCM0322  AC59 HEK-293T C305(1.02)  LDD0920  [6]
 LDCM0323  AC6 HEK-293T C103(0.97); C305(1.01); C35(0.94)  LDD1562  [18]
 LDCM0324  AC60 HEK-293T C305(0.67)  LDD0922  [6]
 LDCM0325  AC61 HEK-293T C305(0.82)  LDD0923  [6]
 LDCM0326  AC62 HEK-293T C305(0.96)  LDD0924  [6]
 LDCM0327  AC63 HEK-293T C305(0.84)  LDD0925  [6]
 LDCM0328  AC64 HEK-293T C305(1.11)  LDD0926  [6]
 LDCM0329  AC65 HEK-293T C305(0.95)  LDD0927  [6]
 LDCM0330  AC66 HEK-293T C305(1.01)  LDD0928  [6]
 LDCM0331  AC67 HEK-293T C305(0.79)  LDD0929  [6]
 LDCM0332  AC68 HEK-293T C305(0.71)  LDD0930  [6]
 LDCM0333  AC69 HEK-293T C305(0.61)  LDD0931  [6]
 LDCM0334  AC7 HEK-293T C103(1.10); C305(1.01); C35(1.00)  LDD1568  [18]
 LDCM0335  AC70 HEK-293T C305(0.87)  LDD0933  [6]
 LDCM0336  AC71 HEK-293T C305(1.00)  LDD0934  [6]
 LDCM0337  AC72 HEK-293T C305(0.63)  LDD0935  [6]
 LDCM0338  AC73 HEK-293T C305(0.77)  LDD0936  [6]
 LDCM0339  AC74 HEK-293T C305(0.93)  LDD0937  [6]
 LDCM0340  AC75 HEK-293T C305(0.81)  LDD0938  [6]
 LDCM0341  AC76 HEK-293T C305(0.73)  LDD0939  [6]
 LDCM0342  AC77 HEK-293T C305(0.60)  LDD0940  [6]
 LDCM0343  AC78 HEK-293T C305(0.78)  LDD0941  [6]
 LDCM0344  AC79 HEK-293T C305(0.81)  LDD0942  [6]
 LDCM0345  AC8 HEK-293T C103(0.89); C305(0.94); C35(0.97)  LDD1569  [18]
 LDCM0346  AC80 HEK-293T C305(0.83)  LDD0944  [6]
 LDCM0347  AC81 HEK-293T C305(0.86)  LDD0945  [6]
 LDCM0348  AC82 HEK-293T C305(0.95)  LDD0946  [6]
 LDCM0349  AC83 HEK-293T C305(1.26)  LDD0947  [6]
 LDCM0350  AC84 HEK-293T C305(1.12)  LDD0948  [6]
 LDCM0351  AC85 HEK-293T C305(1.40)  LDD0949  [6]
 LDCM0352  AC86 HEK-293T C305(0.95)  LDD0950  [6]
 LDCM0353  AC87 HEK-293T C305(1.23)  LDD0951  [6]
 LDCM0354  AC88 HEK-293T C305(1.42)  LDD0952  [6]
 LDCM0355  AC89 HEK-293T C305(1.12)  LDD0953  [6]
 LDCM0357  AC90 HEK-293T C305(1.01)  LDD0955  [6]
 LDCM0358  AC91 HEK-293T C305(1.13)  LDD0956  [6]
 LDCM0359  AC92 HEK-293T C305(1.32)  LDD0957  [6]
 LDCM0360  AC93 HEK-293T C305(1.08)  LDD0958  [6]
 LDCM0361  AC94 HEK-293T C305(1.13)  LDD0959  [6]
 LDCM0362  AC95 HEK-293T C305(1.03)  LDD0960  [6]
 LDCM0363  AC96 HEK-293T C305(1.17)  LDD0961  [6]
 LDCM0364  AC97 HEK-293T C305(1.28)  LDD0962  [6]
 LDCM0365  AC98 HEK-293T C305(1.18)  LDD0963  [6]
 LDCM0366  AC99 HEK-293T C305(0.98)  LDD0964  [6]
 LDCM0248  AKOS034007472 HEK-293T C103(1.02); C305(1.11); C35(0.98)  LDD1511  [18]
 LDCM0356  AKOS034007680 HEK-293T C103(1.22); C305(0.95); C35(0.94)  LDD1570  [18]
 LDCM0275  AKOS034007705 HEK-293T C103(1.28); C305(0.99); C35(1.02)  LDD1514  [18]
 LDCM0156  Aniline NCI-H1299 12.21  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C103(1.11)  LDD0078  [6]
 LDCM0108  Chloroacetamide HeLa C305(0.00); C35(0.00); C103(0.00)  LDD0222  [13]
 LDCM0367  CL1 PaTu 8988t C103(1.16)  LDD1246  [6]
 LDCM0368  CL10 PaTu 8988t C103(1.72)  LDD1247  [6]
 LDCM0369  CL100 PaTu 8988t C305(1.06)  LDD1248  [6]
 LDCM0370  CL101 HEK-293T C103(1.30); C305(1.01); C35(1.02)  LDD1574  [18]
 LDCM0371  CL102 HEK-293T C305(1.19); C35(0.97); C999(1.22)  LDD1575  [18]
 LDCM0372  CL103 HEK-293T C103(1.67); C305(0.99); C35(0.98)  LDD1576  [18]
 LDCM0373  CL104 HEK-293T C305(1.02); C35(0.84)  LDD1577  [18]
 LDCM0374  CL105 HEK-293T C305(1.20)  LDD0972  [6]
 LDCM0375  CL106 HEK-293T C305(0.87)  LDD0973  [6]
 LDCM0376  CL107 HEK-293T C305(1.09)  LDD0974  [6]
 LDCM0377  CL108 HEK-293T C305(1.39)  LDD0975  [6]
 LDCM0378  CL109 HEK-293T C305(0.99)  LDD0976  [6]
 LDCM0379  CL11 PaTu 8988t C103(0.86)  LDD1258  [6]
 LDCM0380  CL110 HEK-293T C305(1.03)  LDD0978  [6]
 LDCM0381  CL111 HEK-293T C305(0.93)  LDD0979  [6]
 LDCM0382  CL112 PaTu 8988t C103(0.97)  LDD1261  [6]
 LDCM0383  CL113 PaTu 8988t C103(1.02)  LDD1262  [6]
 LDCM0384  CL114 PaTu 8988t C103(0.91)  LDD1263  [6]
 LDCM0385  CL115 PaTu 8988t C103(0.91)  LDD1264  [6]
 LDCM0386  CL116 PaTu 8988t C103(0.99)  LDD1265  [6]
 LDCM0387  CL117 HEK-293T C103(1.15); C305(1.01); C35(1.11)  LDD1591  [18]
 LDCM0388  CL118 HEK-293T C305(1.10); C35(0.97); C999(1.22)  LDD1592  [18]
 LDCM0389  CL119 HEK-293T C103(1.33); C305(0.92); C35(0.94)  LDD1593  [18]
 LDCM0390  CL12 PaTu 8988t C103(1.54)  LDD1269  [6]
 LDCM0391  CL120 HEK-293T C305(0.98); C35(1.20)  LDD1595  [18]
 LDCM0392  CL121 HEK-293T C305(1.10)  LDD0990  [6]
 LDCM0393  CL122 HEK-293T C305(0.91)  LDD0991  [6]
 LDCM0394  CL123 HEK-293T C305(0.84)  LDD0992  [6]
 LDCM0395  CL124 HEK-293T C305(0.86)  LDD0993  [6]
 LDCM0396  CL125 HEK-293T C305(0.97)  LDD0994  [6]
 LDCM0397  CL126 HEK-293T C305(0.83)  LDD0995  [6]
 LDCM0398  CL127 HEK-293T C305(0.82)  LDD0996  [6]
 LDCM0399  CL128 HEK-293T C305(1.03)  LDD0997  [6]
 LDCM0400  CL13 PaTu 8988t C103(1.88)  LDD1279  [6]
 LDCM0401  CL14 PaTu 8988t C103(1.06)  LDD1280  [6]
 LDCM0402  CL15 PaTu 8988t C103(1.46)  LDD1281  [6]
 LDCM0403  CL16 HEK-293T C305(1.00)  LDD1001  [6]
 LDCM0404  CL17 HEK-293T C305(0.85)  LDD1002  [6]
 LDCM0405  CL18 HEK-293T C305(1.13)  LDD1003  [6]
 LDCM0406  CL19 HEK-293T C305(1.00)  LDD1004  [6]
 LDCM0407  CL2 PaTu 8988t C103(0.82)  LDD1286  [6]
 LDCM0408  CL20 HEK-293T C305(0.95)  LDD1006  [6]
 LDCM0409  CL21 HEK-293T C305(1.06)  LDD1007  [6]
 LDCM0410  CL22 HEK-293T C305(1.10)  LDD1008  [6]
 LDCM0411  CL23 HEK-293T C305(0.98)  LDD1009  [6]
 LDCM0412  CL24 HEK-293T C305(0.98)  LDD1010  [6]
 LDCM0413  CL25 HEK-293T C305(1.07)  LDD1011  [6]
 LDCM0414  CL26 HEK-293T C305(0.98)  LDD1012  [6]
 LDCM0415  CL27 HEK-293T C305(1.03)  LDD1013  [6]
 LDCM0416  CL28 HEK-293T C305(1.05)  LDD1014  [6]
 LDCM0417  CL29 HEK-293T C305(1.04)  LDD1015  [6]
 LDCM0418  CL3 PaTu 8988t C103(1.18)  LDD1297  [6]
 LDCM0419  CL30 HEK-293T C305(1.18)  LDD1017  [6]
 LDCM0420  CL31 HEK-293T C305(1.03)  LDD1018  [6]
 LDCM0421  CL32 HEK-293T C305(1.21)  LDD1019  [6]
 LDCM0422  CL33 HEK-293T C305(1.29)  LDD1020  [6]
 LDCM0423  CL34 HEK-293T C305(1.07)  LDD1021  [6]
 LDCM0424  CL35 HEK-293T C305(1.08)  LDD1022  [6]
 LDCM0425  CL36 HEK-293T C305(0.92)  LDD1023  [6]
 LDCM0426  CL37 HEK-293T C305(1.09)  LDD1024  [6]
 LDCM0428  CL39 HEK-293T C305(1.10)  LDD1026  [6]
 LDCM0429  CL4 PaTu 8988t C103(1.18)  LDD1308  [6]
 LDCM0430  CL40 HEK-293T C305(0.90)  LDD1028  [6]
 LDCM0431  CL41 HEK-293T C305(1.00)  LDD1029  [6]
 LDCM0432  CL42 HEK-293T C305(1.14)  LDD1030  [6]
 LDCM0433  CL43 HEK-293T C305(1.15)  LDD1031  [6]
 LDCM0434  CL44 HEK-293T C305(1.05)  LDD1032  [6]
 LDCM0435  CL45 HEK-293T C305(1.01)  LDD1033  [6]
 LDCM0436  CL46 HEK-293T C305(1.26)  LDD1034  [6]
 LDCM0437  CL47 HEK-293T C305(1.23)  LDD1035  [6]
 LDCM0438  CL48 HEK-293T C305(1.21)  LDD1036  [6]
 LDCM0439  CL49 HEK-293T C305(0.96)  LDD1037  [6]
 LDCM0440  CL5 PaTu 8988t C103(1.29)  LDD1319  [6]
 LDCM0441  CL50 HEK-293T C305(1.11)  LDD1039  [6]
 LDCM0442  CL51 HEK-293T C305(1.06)  LDD1040  [6]
 LDCM0443  CL52 HEK-293T C305(1.17)  LDD1041  [6]
 LDCM0444  CL53 HEK-293T C305(1.06)  LDD1042  [6]
 LDCM0445  CL54 HEK-293T C305(1.06)  LDD1043  [6]
 LDCM0446  CL55 HEK-293T C305(1.10)  LDD1044  [6]
 LDCM0447  CL56 HEK-293T C305(1.20)  LDD1045  [6]
 LDCM0448  CL57 HEK-293T C305(1.05)  LDD1046  [6]
 LDCM0449  CL58 HEK-293T C305(0.93)  LDD1047  [6]
 LDCM0450  CL59 HEK-293T C305(1.14)  LDD1048  [6]
 LDCM0451  CL6 PaTu 8988t C103(1.32)  LDD1330  [6]
 LDCM0452  CL60 HEK-293T C305(1.25)  LDD1050  [6]
 LDCM0453  CL61 PaTu 8988t C103(0.91)  LDD1332  [6]
 LDCM0454  CL62 PaTu 8988t C103(1.10)  LDD1333  [6]
 LDCM0455  CL63 PaTu 8988t C103(1.11)  LDD1334  [6]
 LDCM0456  CL64 PaTu 8988t C103(1.69)  LDD1335  [6]
 LDCM0457  CL65 PaTu 8988t C103(1.02)  LDD1336  [6]
 LDCM0458  CL66 PaTu 8988t C103(1.13)  LDD1337  [6]
 LDCM0459  CL67 PaTu 8988t C103(1.49)  LDD1338  [6]
 LDCM0460  CL68 PaTu 8988t C103(1.40)  LDD1339  [6]
 LDCM0461  CL69 PaTu 8988t C103(1.71)  LDD1340  [6]
 LDCM0462  CL7 PaTu 8988t C103(0.85)  LDD1341  [6]
 LDCM0463  CL70 PaTu 8988t C103(1.37)  LDD1342  [6]
 LDCM0464  CL71 PaTu 8988t C103(1.19)  LDD1343  [6]
 LDCM0465  CL72 PaTu 8988t C103(0.88)  LDD1344  [6]
 LDCM0466  CL73 PaTu 8988t C103(1.61)  LDD1345  [6]
 LDCM0467  CL74 PaTu 8988t C103(1.16)  LDD1346  [6]
 LDCM0469  CL76 PaTu 8988t C103(0.85)  LDD1348  [6]
 LDCM0470  CL77 PaTu 8988t C103(0.77)  LDD1349  [6]
 LDCM0471  CL78 PaTu 8988t C103(0.75)  LDD1350  [6]
 LDCM0472  CL79 PaTu 8988t C103(0.98)  LDD1351  [6]
 LDCM0473  CL8 PaTu 8988t C103(2.27)  LDD1352  [6]
 LDCM0474  CL80 PaTu 8988t C103(1.07)  LDD1353  [6]
 LDCM0475  CL81 PaTu 8988t C103(1.15)  LDD1354  [6]
 LDCM0476  CL82 PaTu 8988t C103(0.88)  LDD1355  [6]
 LDCM0477  CL83 PaTu 8988t C103(1.00)  LDD1356  [6]
 LDCM0478  CL84 PaTu 8988t C103(1.00)  LDD1357  [6]
 LDCM0479  CL85 PaTu 8988t C103(1.09)  LDD1358  [6]
 LDCM0480  CL86 PaTu 8988t C103(1.46)  LDD1359  [6]
 LDCM0481  CL87 PaTu 8988t C103(1.00)  LDD1360  [6]
 LDCM0482  CL88 PaTu 8988t C103(0.97)  LDD1361  [6]
 LDCM0483  CL89 PaTu 8988t C103(1.02)  LDD1362  [6]
 LDCM0484  CL9 PaTu 8988t C103(0.98)  LDD1363  [6]
 LDCM0485  CL90 PaTu 8988t C103(1.38)  LDD1364  [6]
 LDCM0486  CL91 PaTu 8988t C305(1.23)  LDD1365  [6]
 LDCM0487  CL92 PaTu 8988t C305(0.83)  LDD1366  [6]
 LDCM0488  CL93 PaTu 8988t C305(0.92)  LDD1367  [6]
 LDCM0489  CL94 PaTu 8988t C305(0.86)  LDD1368  [6]
 LDCM0490  CL95 PaTu 8988t C305(0.93)  LDD1369  [6]
 LDCM0491  CL96 PaTu 8988t C305(1.02)  LDD1370  [6]
 LDCM0492  CL97 PaTu 8988t C305(0.94)  LDD1371  [6]
 LDCM0493  CL98 PaTu 8988t C305(0.94)  LDD1372  [6]
 LDCM0494  CL99 PaTu 8988t C305(0.88)  LDD1373  [6]
 LDCM0495  E2913 HEK-293T C103(0.86); C305(1.02); C35(0.92)  LDD1698  [18]
 LDCM0625  F8 Ramos C305(0.69)  LDD2187  [19]
 LDCM0572  Fragment10 Ramos C305(0.97)  LDD2189  [19]
 LDCM0573  Fragment11 Ramos C305(0.45)  LDD2190  [19]
 LDCM0574  Fragment12 Ramos C305(0.92)  LDD2191  [19]
 LDCM0575  Fragment13 Ramos C305(1.39)  LDD2192  [19]
 LDCM0576  Fragment14 Ramos C305(1.22)  LDD2193  [19]
 LDCM0579  Fragment20 Ramos C305(1.08)  LDD2194  [19]
 LDCM0580  Fragment21 Ramos C305(1.08)  LDD2195  [19]
 LDCM0582  Fragment23 Ramos C305(1.24)  LDD2196  [19]
 LDCM0578  Fragment27 Ramos C305(0.99)  LDD2197  [19]
 LDCM0586  Fragment28 Ramos C305(0.50)  LDD2198  [19]
 LDCM0588  Fragment30 Ramos C305(1.41)  LDD2199  [19]
 LDCM0589  Fragment31 Ramos C305(1.19)  LDD2200  [19]
 LDCM0590  Fragment32 Ramos C305(0.91)  LDD2201  [19]
 LDCM0468  Fragment33 PaTu 8988t C103(1.11)  LDD1347  [6]
 LDCM0596  Fragment38 Ramos C305(0.96)  LDD2203  [19]
 LDCM0566  Fragment4 Ramos C305(0.93)  LDD2184  [19]
 LDCM0427  Fragment51 HEK-293T C305(1.16)  LDD1025  [6]
 LDCM0610  Fragment52 Ramos C305(1.60)  LDD2204  [19]
 LDCM0614  Fragment56 Ramos C305(0.98)  LDD2205  [19]
 LDCM0569  Fragment7 Ramos C305(0.79)  LDD2186  [19]
 LDCM0571  Fragment9 Ramos C305(0.82)  LDD2188  [19]
 LDCM0022  KB02 HEK-293T C35(1.03); C305(0.81)  LDD1492  [18]
 LDCM0023  KB03 HEK-293T C35(1.03); C305(0.98)  LDD1497  [18]
 LDCM0024  KB05 COLO792 C305(2.36)  LDD3310  [20]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Poly [ADP-ribose] polymerase tankyrase-2 (TNKS2) ARTD/PARP family Q9H2K2
Glutathione hydrolase 7 (GGT7) Gamma-glutamyltransferase family Q9UJ14
Probable glutathione peroxidase 8 (GPX8) Glutathione peroxidase family Q8TED1
Estradiol 17-beta-dehydrogenase 11 (HSD17B11) Short-chain dehydrogenases/reductases (SDR) family Q8NBQ5
TLC domain-containing protein 4 (TLCD4) TLCD4 family Q96MV1
Transporter and channel
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Stomatin (STOM) Band 7/mec-2 family P27105
Novel acetylcholine receptor chaperone (TMEM35A) DoxX family Q53FP2
LHFPL tetraspan subfamily member 5 protein (LHFPL5) LHFP family Q8TAF8
ER membrane protein complex subunit 5 (MMGT1) Membrane magnesium transporter (TC 1.A.67) family Q8N4V1
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Solute carrier family 35 member E3 (SLC35E3) TPT transporter family Q7Z769
Zinc transporter ZIP9 (SLC39A9) ZIP transporter (TC 2.A.5) family Q9NUM3
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Proto-oncogene c-Rel (REL) . Q04864
Transcription factor 4 (TCF4) . P15884
GPCR
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
G-protein coupled receptor 42 (GPR42) G-protein coupled receptor 1 family O15529
Taste receptor type 2 member 19 (TAS2R19) G-protein coupled receptor T2R family P59542
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Neutrophil gelatinase-associated lipocalin (LCN2) Lipocalin family P80188
Cancer/testis antigen 1 (CTAG1A; CTAG1B) CTAG/PCC1 family P78358
Receptor expression-enhancing protein 4 (REEP4) DP1 family Q9H6H4
Protein FAM210B, mitochondrial (FAM210B) FAM210 family Q96KR6
Cell growth regulator with RING finger domain protein 1 (CGRRF1) . Q99675
Fetal and adult testis-expressed transcript protein (FATE1) . Q969F0
Serine-rich single-pass membrane protein 1 (SSMEM1) . Q8WWF3
Ubiquilin-1 (UBQLN1) . Q9UMX0

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Oxytocin Protein/peptide DB00107
Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Inhibitor 19 Small molecular drug D04DTE
Pmid23916253c17 Small molecular drug D02MNM
Patented
Click To Hide/Show 7 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Us10023583, Example 13 Small molecular drug D0V4YX
Us10023583, Example 24 Small molecular drug D0IC5Y
Us10023583, Example 5 Small molecular drug D0HO8O
Us10023583, Example 8 Small molecular drug D0X2XN
Us10059720, Example 80 Small molecular drug D04AFR
Us10059720, Example 82 Small molecular drug D05ZEZ
Us10059720, Example 84 Small molecular drug D06JLW

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
12 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
13 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
14 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
15 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
16 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
17 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
19 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
20 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840