Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C425  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 38 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02223  Cathepsin B (CTSB) 47.2
 LDTP00428  Tripeptidyl-peptidase 1 (TPP1) 31.3
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 26.4
 LDTP00316  Ribonuclease T2 (RNASET2) 25.1
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 23.3
 LDTP02141  Alpha-galactosidase A (GLA) 22.6
 LDTP09256  Putative phospholipase B-like 2 (PLBD2) 22.5
 LDTP02799  N-acetylglucosamine-6-sulfatase (GNS) 22.3
 LDTP04634  Alpha-N-acetylglucosaminidase (NAGLU) 20.7
 LDTP13620  Lysosomal thioesterase PPT2 (PPT2) 20.4
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 20.4
 LDTP11215  Plasma alpha-L-fucosidase (FUCA2) 19.2
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 18.5
 LDTP02169  Beta-hexosaminidase subunit alpha (HEXA) 17.9
 LDTP02539  Lysosomal acid phosphatase (ACP2) 17.9
 LDTP02486  Lysosomal alpha-glucosidase (GAA) 17.4
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 16.9
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 15.1
 LDTP02837  Beta-galactosidase (GLB1) 13.5
 LDTP09886  Gamma-glutamyl hydrolase (GGH) 13.5
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 11.8
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 11.4
 LDTP02505  Lysosomal protective protein (CTSA) 11.1
 LDTP15422  Prostaglandin reductase 3 (PTGR3) 11.1
 LDTP00282  Beta-mannosidase (MANBA) 10.8
 LDTP02006  Tissue alpha-L-fucosidase (FUCA1) 10.7
 LDTP02216  Beta-hexosaminidase subunit beta (HEXB) 10.5
 LDTP04572  Dipeptidyl peptidase 1 (CTSC) 10.5
 LDTP01372  Carboxypeptidase D (CPD) 10.2
 LDTP09088  Phospholipase A2 group XV (PLA2G15) 9.5
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 8.6
 LDTP05905  Acid ceramidase (ASAH1) 8.5
 LDTP00482  Peripheral plasma membrane protein CASK (CASK) 7.6
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 7.1
 LDTP13131  7-dehydrocholesterol reductase (DHCR7) 7.1
 LDTP02260  Beta-glucuronidase (GUSB) 6.9
 LDTP08265  N-alpha-acetyltransferase 40 (NAA40) 5.8
 LDTP02005  Lysosomal acid glucosylceramidase (GBA1) 5.4
Transporter and channel
Click to Show/Hide to Show 22 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02215  Prosaposin (PSAP) 20.1
 LDTP04940  NPC intracellular cholesterol transporter 2 (NPC2) 19.2
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 16.3
 LDTP11615  Protein tweety homolog 3 (TTYH3) 15.9
 LDTP02586  Cation-independent mannose-6-phosphate receptor (IGF2R) 14.5
 LDTP01969  Transferrin receptor protein 1 (TFRC) 13.6
 LDTP13833  Integral membrane protein 2B (ITM2B) 13.4
 LDTP10885  Sortilin (SORT1) 13.0
 LDTP06499  V-type proton ATPase subunit S1 (ATP6AP1) 11.5
 LDTP05538  Prolow-density lipoprotein receptor-related protein 1 (LRP1) 10.9
 LDTP00321  Podocalyxin (PODXL) 10.6
 LDTP02562  Lysosome-associated membrane glycoprotein 1 (LAMP1) 10.4
 LDTP04612  Voltage-dependent calcium channel subunit alpha-2/delta-1 (CACNA2D1) 9.0
 LDTP17641  Solute carrier family 35 member F2 (SLC35F2) 8.9
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 8.9
 LDTP00541  NPC intracellular cholesterol transporter 1 (NPC1) 8.5
 LDTP01427  Slit homolog 2 protein (SLIT2) 7.3
 LDTP04459  H(+)/Cl(-) exchange transporter 3 (CLCN3) 7.1
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 7.1
 LDTP08016  Proton-coupled amino acid transporter 1 (SLC36A1) 5.4
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 5.3
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 5.3
Immunoglobulin
Click to Show/Hide to Show 5 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP04720  IgG receptor FcRn large subunit p51 (FCGRT) 18.5
 LDTP02040  HLA class I histocompatibility antigen, A alpha chain (HLA-A) 10.0
 LDTP01913  HLA class I histocompatibility antigen, B alpha chain (HLA-B) 9.5
 LDTP02491  HLA class I histocompatibility antigen, C alpha chain (HLA-C) 5.6
 LDTP14203  Junctional adhesion molecule A (F11R) 5.1
Cytokine and receptor
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02775  Interferon gamma receptor 1 (IFNGR1) 21.9
Other
Click to Show/Hide to Show 12 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05491  Amyloid beta precursor like protein 2 (APLP2) 32.0
 LDTP05558  Galectin-3-binding protein (LGALS3BP) 22.6
 LDTP02927  Ganglioside GM2 activator (GM2A) 15.8
 LDTP01075  Protein CutA (CUTA) 13.4
 LDTP09787  Nicastrin (NCSTN) 11.2
 LDTP00779  Trans-Golgi network integral membrane protein 2 (TGOLN2) 11.2
 LDTP07031  Collectin-12 (COLEC12) 10.3
 LDTP08689  Dyslexia-associated protein KIAA0319-like protein (KIAA0319L) 7.3
 LDTP04207  Heat shock 70 kDa protein 13 (HSPA13) 6.2
 LDTP09920  Golgi apparatus protein 1 (GLG1) 6.1
 LDTP09054  Golgi membrane protein 1 (GOLM1) 6.0
 LDTP07934  Synaptic vesicle glycoprotein 2A (SV2A) 5.6

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587