Details of the Target

General Information of Target

Target ID LDTP12013
Target Name dCTP pyrophosphatase 1 (DCTPP1)
Gene Name DCTPP1
Gene ID 79077
Synonyms
XTP3TPA; dCTP pyrophosphatase 1; EC 3.6.1.12; Deoxycytidine-triphosphatase 1; dCTPase 1; RS21C6; XTP3-transactivated gene A protein
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MFWKLSLSLFLVAVLVKVAEARKNRPAGAIPSPYKDGSSNNSERWQHQIKEVLASSQEAL
VVTERKYLKSDWCKTQPLRQTVSEEGCRSRTILNRFCYGQCNSFYIPRHVKKEEESFQSC
AFCKPQRVTSVLVELECPGLDPPFRLKKIQKVKQCRCMSVNLSDSDKQ
Target Bioclass
Enzyme
Subcellular location
Mitochondrion
Function
Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.
TTD ID
T01249
Uniprot ID
Q9H773
DrugMap ID
TTZ1YIS
Ensemble ID
ENST00000319285.5
HGNC ID
HGNC:28777
ChEMBL ID
CHEMBL3769292

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 31 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
SAA-alkyne
 Probe Info  		1.12  LDD0252  [2]
TH211
 Probe Info  		Y141(20.00); Y129(12.48); Y102(9.10)  LDD0257  [3]
TH214
 Probe Info  		Y102(17.90); Y129(7.22)  LDD0258  [3]
TH216
 Probe Info  		Y102(18.37); Y141(13.82); Y129(11.73)  LDD0259  [3]
Probe 1
 Probe Info  		Y129(37.88)  LDD3495  [4]
DA-P3
 Probe Info  		35.87  LDD0180  [5]
AHL-Pu-1
 Probe Info  		C162(2.23)  LDD0169  [6]
HHS-482
 Probe Info  		Y129(3.26)  LDD0287  [7]
HHS-475
 Probe Info  		Y141(0.89); Y102(1.12); Y129(1.14)  LDD0264  [8]
HHS-465
 Probe Info  		Y102(3.26); Y129(6.10); Y141(10.00)  LDD2237  [9]
DBIA
 Probe Info  		C162(1.45)  LDD0080  [10]
ATP probe
 Probe Info  		N.A.  LDD0199  [11]
4-Iodoacetamidophenylacetylene
 Probe Info  		C162(0.00); C110(0.00)  LDD0038  [12]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [13]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [12]
ATP probe
 Probe Info  		N.A.  LDD0035  [14]
IPM
 Probe Info  		N.A.  LDD0025  [15]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [15]
NAIA_4
 Probe Info  		N.A.  LDD2226  [16]
TFBX
 Probe Info  		C110(0.00); C162(0.00)  LDD0027  [15]
ENE
 Probe Info  		N.A.  LDD0006  [17]
SF
 Probe Info  		N.A.  LDD0028  [18]
VSF
 Probe Info  		N.A.  LDD0007  [17]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [19]
Ox-W18
 Probe Info  		W47(0.00); W73(0.00)  LDD2175  [20]
1c-yne
 Probe Info  		N.A.  LDD0228  [21]
Acrolein
 Probe Info  		H38(0.00); C162(0.00)  LDD0217  [22]
W1
 Probe Info  		N.A.  LDD0236  [23]
AOyne
 Probe Info  		8.50  LDD0443  [24]
NAIA_5
 Probe Info  		C110(0.00); C162(0.00)  LDD2223  [16]
PAL-AfBPP Probe
Click To Hide/Show 136 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C003
 Probe Info  		12.82  LDD1713  [25]
C006
 Probe Info  		6.32  LDD1715  [25]
C010
 Probe Info  		8.06  LDD1719  [25]
C013
 Probe Info  		5.21  LDD1722  [25]
C021
 Probe Info  		10.34  LDD1727  [25]
C026
 Probe Info  		6.11  LDD1732  [25]
C039
 Probe Info  		26.17  LDD1739  [25]
C040
 Probe Info  		7.84  LDD1740  [25]
C041
 Probe Info  		9.85  LDD1741  [25]
C042
 Probe Info  		9.78  LDD1742  [25]
C053
 Probe Info  		5.39  LDD1751  [25]
C064
 Probe Info  		7.36  LDD1761  [25]
C072
 Probe Info  		16.56  LDD1768  [25]
C084
 Probe Info  		7.31  LDD1776  [25]
C089
 Probe Info  		8.69  LDD1781  [25]
C095
 Probe Info  		8.82  LDD1786  [25]
C102
 Probe Info  		5.90  LDD1790  [25]
C108
 Probe Info  		8.57  LDD1795  [25]
C111
 Probe Info  		5.94  LDD1798  [25]
C116
 Probe Info  		8.40  LDD1803  [25]
C117
 Probe Info  		5.43  LDD1804  [25]
C131
 Probe Info  		6.41  LDD1813  [25]
C132
 Probe Info  		30.27  LDD1814  [25]
C134
 Probe Info  		34.54  LDD1816  [25]
C137
 Probe Info  		10.63  LDD1819  [25]
C139
 Probe Info  		10.85  LDD1821  [25]
C140
 Probe Info  		35.75  LDD1822  [25]
C142
 Probe Info  		5.21  LDD1824  [25]
C145
 Probe Info  		13.93  LDD1827  [25]
C146
 Probe Info  		13.00  LDD1828  [25]
C147
 Probe Info  		8.17  LDD1829  [25]
C149
 Probe Info  		6.77  LDD1830  [25]
C153
 Probe Info  		16.68  LDD1834  [25]
C157
 Probe Info  		5.54  LDD1837  [25]
C163
 Probe Info  		9.99  LDD1843  [25]
C165
 Probe Info  		19.84  LDD1845  [25]
C166
 Probe Info  		16.00  LDD1846  [25]
C167
 Probe Info  		8.00  LDD1847  [25]
C170
 Probe Info  		24.42  LDD1850  [25]
C174
 Probe Info  		5.58  LDD1854  [25]
C176
 Probe Info  		6.06  LDD1855  [25]
C186
 Probe Info  		30.48  LDD1864  [25]
C191
 Probe Info  		15.45  LDD1868  [25]
C193
 Probe Info  		5.39  LDD1869  [25]
C195
 Probe Info  		5.21  LDD1871  [25]
C197
 Probe Info  		21.86  LDD1873  [25]
C203
 Probe Info  		15.67  LDD1878  [25]
C205
 Probe Info  		27.67  LDD1880  [25]
C206
 Probe Info  		37.27  LDD1881  [25]
C211
 Probe Info  		12.21  LDD1885  [25]
C212
 Probe Info  		6.32  LDD1886  [25]
C213
 Probe Info  		19.84  LDD1887  [25]
C216
 Probe Info  		5.66  LDD1890  [25]
C218
 Probe Info  		12.55  LDD1892  [25]
C220
 Probe Info  		43.41  LDD1894  [25]
C222
 Probe Info  		8.17  LDD1896  [25]
C227
 Probe Info  		19.43  LDD1900  [25]
C229
 Probe Info  		13.18  LDD1902  [25]
C232
 Probe Info  		42.22  LDD1905  [25]
C233
 Probe Info  		36.76  LDD1906  [25]
C235
 Probe Info  		30.27  LDD1908  [25]
C242
 Probe Info  		20.68  LDD1915  [25]
C243
 Probe Info  		10.93  LDD1916  [25]
C249
 Probe Info  		20.97  LDD1922  [25]
C254
 Probe Info  		29.04  LDD1927  [25]
C258
 Probe Info  		7.11  LDD1931  [25]
C260
 Probe Info  		14.32  LDD1932  [25]
C265
 Probe Info  		32.90  LDD1936  [25]
C268
 Probe Info  		6.82  LDD1938  [25]
C270
 Probe Info  		7.84  LDD1940  [25]
C273
 Probe Info  		5.74  LDD1943  [25]
C277
 Probe Info  		10.27  LDD1947  [25]
C279
 Probe Info  		41.93  LDD1949  [25]
C280
 Probe Info  		25.28  LDD1950  [25]
C286
 Probe Info  		24.93  LDD1956  [25]
C288
 Probe Info  		10.34  LDD1958  [25]
C290
 Probe Info  		11.88  LDD1960  [25]
C293
 Probe Info  		27.86  LDD1963  [25]
C295
 Probe Info  		14.62  LDD1965  [25]
C301
 Probe Info  		6.73  LDD1970  [25]
C302
 Probe Info  		10.48  LDD1971  [25]
C303
 Probe Info  		26.72  LDD1972  [25]
C305
 Probe Info  		14.83  LDD1974  [25]
C307
 Probe Info  		14.52  LDD1975  [25]
C309
 Probe Info  		5.39  LDD1976  [25]
C313
 Probe Info  		12.21  LDD1980  [25]
C317
 Probe Info  		10.85  LDD1983  [25]
C319
 Probe Info  		9.38  LDD1985  [25]
C322
 Probe Info  		6.92  LDD1988  [25]
C326
 Probe Info  		64.45  LDD1990  [25]
C328
 Probe Info  		8.63  LDD1992  [25]
C331
 Probe Info  		25.11  LDD1994  [25]
C337
 Probe Info  		17.15  LDD2000  [25]
C340
 Probe Info  		7.62  LDD2003  [25]
C342
 Probe Info  		26.17  LDD2004  [25]
C343
 Probe Info  		38.85  LDD2005  [25]
C346
 Probe Info  		23.59  LDD2007  [25]
C347
 Probe Info  		8.51  LDD2008  [25]
C348
 Probe Info  		10.06  LDD2009  [25]
C349
 Probe Info  		8.69  LDD2010  [25]
C350
 Probe Info  		23.59  LDD2011  [25]
C353
 Probe Info  		10.93  LDD2014  [25]
C356
 Probe Info  		14.62  LDD2017  [25]
C359
 Probe Info  		19.03  LDD2020  [25]
C361
 Probe Info  		34.06  LDD2022  [25]
C365
 Probe Info  		26.17  LDD2026  [25]
C374
 Probe Info  		14.12  LDD2034  [25]
C376
 Probe Info  		47.84  LDD2036  [25]
C383
 Probe Info  		14.52  LDD2042  [25]
C385
 Probe Info  		44.94  LDD2044  [25]
C386
 Probe Info  		13.00  LDD2045  [25]
C390
 Probe Info  		27.28  LDD2049  [25]
C391
 Probe Info  		15.89  LDD2050  [25]
C397
 Probe Info  		11.63  LDD2056  [25]
C399
 Probe Info  		26.91  LDD2058  [25]
C409
 Probe Info  		7.57  LDD2066  [25]
C411
 Probe Info  		12.13  LDD2067  [25]
C413
 Probe Info  		23.92  LDD2069  [25]
C414
 Probe Info  		31.12  LDD2070  [25]
C417
 Probe Info  		15.78  LDD2072  [25]
C419
 Probe Info  		16.45  LDD2074  [25]
C425
 Probe Info  		11.79  LDD2080  [25]
C427
 Probe Info  		11.16  LDD2082  [25]
C431
 Probe Info  		21.41  LDD2086  [25]
FFF probe11
 Probe Info  		20.00  LDD0471  [26]
FFF probe13
 Probe Info  		20.00  LDD0475  [26]
FFF probe14
 Probe Info  		20.00  LDD0477  [26]
FFF probe3
 Probe Info  		13.11  LDD0464  [26]
FFF probe4
 Probe Info  		16.07  LDD0466  [26]
FFF probe6
 Probe Info  		15.99  LDD0482  [26]
FFF probe7
 Probe Info  		7.98  LDD0483  [26]
FFF probe9
 Probe Info  		6.66  LDD0470  [26]
JN0003
 Probe Info  		20.00  LDD0469  [26]
Kambe_22
 Probe Info  		20.00  LDD0125  [27]
Kambe_55
 Probe Info  		12.93  LDD0129  [27]
OEA-DA
 Probe Info  		13.15  LDD0046  [28]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C162(2.23)  LDD0169  [6]
 LDCM0214  AC1 HEK-293T C162(1.02)  LDD1507  [29]
 LDCM0215  AC10 HEK-293T C162(0.90)  LDD1508  [29]
 LDCM0226  AC11 HEK-293T C162(1.10)  LDD1509  [29]
 LDCM0237  AC12 HEK-293T C162(1.35)  LDD1510  [29]
 LDCM0259  AC14 HEK-293T C162(1.11)  LDD1512  [29]
 LDCM0270  AC15 HEK-293T C162(1.25)  LDD1513  [29]
 LDCM0276  AC17 HEK-293T C162(1.36)  LDD1515  [29]
 LDCM0277  AC18 HEK-293T C162(1.19)  LDD1516  [29]
 LDCM0278  AC19 HEK-293T C162(1.24)  LDD1517  [29]
 LDCM0279  AC2 HEK-293T C162(0.96)  LDD1518  [29]
 LDCM0280  AC20 HEK-293T C162(1.28)  LDD1519  [29]
 LDCM0281  AC21 HEK-293T C162(1.17)  LDD1520  [29]
 LDCM0282  AC22 HEK-293T C162(1.12)  LDD1521  [29]
 LDCM0283  AC23 HEK-293T C162(1.47)  LDD1522  [29]
 LDCM0284  AC24 HEK-293T C162(1.19)  LDD1523  [29]
 LDCM0285  AC25 HEK-293T C162(1.09)  LDD1524  [29]
 LDCM0286  AC26 HEK-293T C162(0.89)  LDD1525  [29]
 LDCM0287  AC27 HEK-293T C162(1.15)  LDD1526  [29]
 LDCM0288  AC28 HEK-293T C162(1.32)  LDD1527  [29]
 LDCM0289  AC29 HEK-293T C162(1.02)  LDD1528  [29]
 LDCM0290  AC3 HEK-293T C162(0.85)  LDD1529  [29]
 LDCM0291  AC30 HEK-293T C162(0.92)  LDD1530  [29]
 LDCM0292  AC31 HEK-293T C162(1.07)  LDD1531  [29]
 LDCM0293  AC32 HEK-293T C162(1.18)  LDD1532  [29]
 LDCM0294  AC33 HEK-293T C162(1.44)  LDD1533  [29]
 LDCM0295  AC34 HEK-293T C162(1.19)  LDD1534  [29]
 LDCM0296  AC35 HEK-293T C162(1.74)  LDD1535  [29]
 LDCM0297  AC36 HEK-293T C162(1.45)  LDD1536  [29]
 LDCM0298  AC37 HEK-293T C162(1.33)  LDD1537  [29]
 LDCM0299  AC38 HEK-293T C162(1.21)  LDD1538  [29]
 LDCM0300  AC39 HEK-293T C162(1.51)  LDD1539  [29]
 LDCM0301  AC4 HEK-293T C162(0.91)  LDD1540  [29]
 LDCM0302  AC40 HEK-293T C162(1.21)  LDD1541  [29]
 LDCM0303  AC41 HEK-293T C162(1.44)  LDD1542  [29]
 LDCM0304  AC42 HEK-293T C162(0.94)  LDD1543  [29]
 LDCM0305  AC43 HEK-293T C162(1.59)  LDD1544  [29]
 LDCM0306  AC44 HEK-293T C162(1.50)  LDD1545  [29]
 LDCM0307  AC45 HEK-293T C162(1.13)  LDD1546  [29]
 LDCM0308  AC46 HEK-293T C162(1.13)  LDD1547  [29]
 LDCM0309  AC47 HEK-293T C162(1.28)  LDD1548  [29]
 LDCM0310  AC48 HEK-293T C162(1.23)  LDD1549  [29]
 LDCM0311  AC49 HEK-293T C162(1.24)  LDD1550  [29]
 LDCM0312  AC5 HEK-293T C162(1.11)  LDD1551  [29]
 LDCM0313  AC50 HEK-293T C162(1.01)  LDD1552  [29]
 LDCM0314  AC51 HEK-293T C162(1.23)  LDD1553  [29]
 LDCM0315  AC52 HEK-293T C162(1.50)  LDD1554  [29]
 LDCM0316  AC53 HEK-293T C162(1.30)  LDD1555  [29]
 LDCM0317  AC54 HEK-293T C162(1.20)  LDD1556  [29]
 LDCM0318  AC55 HEK-293T C162(1.41)  LDD1557  [29]
 LDCM0319  AC56 HEK-293T C162(1.27)  LDD1558  [29]
 LDCM0320  AC57 HEK-293T C162(1.28)  LDD1559  [29]
 LDCM0321  AC58 HEK-293T C162(1.14)  LDD1560  [29]
 LDCM0322  AC59 HEK-293T C162(1.29)  LDD1561  [29]
 LDCM0323  AC6 HEK-293T C162(0.84)  LDD1562  [29]
 LDCM0324  AC60 HEK-293T C162(1.20)  LDD1563  [29]
 LDCM0325  AC61 HEK-293T C162(1.23)  LDD1564  [29]
 LDCM0326  AC62 HEK-293T C162(1.14)  LDD1565  [29]
 LDCM0327  AC63 HEK-293T C162(1.32)  LDD1566  [29]
 LDCM0328  AC64 HEK-293T C162(0.97)  LDD1567  [29]
 LDCM0334  AC7 HEK-293T C162(0.94)  LDD1568  [29]
 LDCM0345  AC8 HEK-293T C162(0.77)  LDD1569  [29]
 LDCM0248  AKOS034007472 HEK-293T C162(1.15)  LDD1511  [29]
 LDCM0356  AKOS034007680 HEK-293T C162(1.05)  LDD1570  [29]
 LDCM0275  AKOS034007705 HEK-293T C162(1.07)  LDD1514  [29]
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa H38(0.00); H132(0.00); C162(0.00)  LDD0222  [22]
 LDCM0632  CL-Sc Hep-G2 C110(5.06)  LDD2227  [16]
 LDCM0367  CL1 HEK-293T C162(1.15)  LDD1571  [29]
 LDCM0368  CL10 HEK-293T C162(0.75)  LDD1572  [29]
 LDCM0369  CL100 HEK-293T C162(1.05)  LDD1573  [29]
 LDCM0370  CL101 HEK-293T C162(1.11)  LDD1574  [29]
 LDCM0371  CL102 HEK-293T C162(0.85)  LDD1575  [29]
 LDCM0372  CL103 HEK-293T C162(1.08)  LDD1576  [29]
 LDCM0373  CL104 HEK-293T C162(0.88)  LDD1577  [29]
 LDCM0374  CL105 HEK-293T C162(1.47)  LDD1578  [29]
 LDCM0375  CL106 HEK-293T C162(0.97)  LDD1579  [29]
 LDCM0376  CL107 HEK-293T C162(0.95)  LDD1580  [29]
 LDCM0377  CL108 HEK-293T C162(1.11)  LDD1581  [29]
 LDCM0378  CL109 HEK-293T C162(1.19)  LDD1582  [29]
 LDCM0379  CL11 HEK-293T C162(1.10)  LDD1583  [29]
 LDCM0380  CL110 HEK-293T C162(0.84)  LDD1584  [29]
 LDCM0381  CL111 HEK-293T C162(0.92)  LDD1585  [29]
 LDCM0382  CL112 HEK-293T C162(1.02)  LDD1586  [29]
 LDCM0383  CL113 HEK-293T C162(1.12)  LDD1587  [29]
 LDCM0384  CL114 HEK-293T C162(1.05)  LDD1588  [29]
 LDCM0385  CL115 HEK-293T C162(1.02)  LDD1589  [29]
 LDCM0386  CL116 HEK-293T C162(1.26)  LDD1590  [29]
 LDCM0387  CL117 HEK-293T C162(1.20)  LDD1591  [29]
 LDCM0388  CL118 HEK-293T C162(1.04)  LDD1592  [29]
 LDCM0389  CL119 HEK-293T C162(0.94)  LDD1593  [29]
 LDCM0390  CL12 HEK-293T C162(1.00)  LDD1594  [29]
 LDCM0391  CL120 HEK-293T C162(1.18)  LDD1595  [29]
 LDCM0392  CL121 HEK-293T C162(1.85)  LDD1596  [29]
 LDCM0393  CL122 HEK-293T C162(0.99)  LDD1597  [29]
 LDCM0394  CL123 HEK-293T C162(0.99)  LDD1598  [29]
 LDCM0395  CL124 HEK-293T C162(0.89)  LDD1599  [29]
 LDCM0396  CL125 HEK-293T C162(1.15)  LDD1600  [29]
 LDCM0397  CL126 HEK-293T C162(0.87)  LDD1601  [29]
 LDCM0398  CL127 HEK-293T C162(0.92)  LDD1602  [29]
 LDCM0399  CL128 HEK-293T C162(1.03)  LDD1603  [29]
 LDCM0400  CL13 HEK-293T C162(1.54)  LDD1604  [29]
 LDCM0401  CL14 HEK-293T C162(1.11)  LDD1605  [29]
 LDCM0402  CL15 HEK-293T C162(1.08)  LDD1606  [29]
 LDCM0403  CL16 HEK-293T C162(0.96)  LDD1607  [29]
 LDCM0404  CL17 HEK-293T C162(1.34)  LDD1608  [29]
 LDCM0405  CL18 HEK-293T C162(1.10)  LDD1609  [29]
 LDCM0406  CL19 HEK-293T C162(1.27)  LDD1610  [29]
 LDCM0407  CL2 HEK-293T C162(1.16)  LDD1611  [29]
 LDCM0408  CL20 HEK-293T C162(1.50)  LDD1612  [29]
 LDCM0409  CL21 HEK-293T C162(0.89)  LDD1613  [29]
 LDCM0410  CL22 HEK-293T C162(1.02)  LDD1614  [29]
 LDCM0411  CL23 HEK-293T C162(1.53)  LDD1615  [29]
 LDCM0412  CL24 HEK-293T C162(0.97)  LDD1616  [29]
 LDCM0413  CL25 HEK-293T C162(1.27)  LDD1617  [29]
 LDCM0414  CL26 HEK-293T C162(1.05)  LDD1618  [29]
 LDCM0415  CL27 HEK-293T C162(0.95)  LDD1619  [29]
 LDCM0416  CL28 HEK-293T C162(0.96)  LDD1620  [29]
 LDCM0417  CL29 HEK-293T C162(1.36)  LDD1621  [29]
 LDCM0418  CL3 HEK-293T C162(0.96)  LDD1622  [29]
 LDCM0419  CL30 HEK-293T C162(1.08)  LDD1623  [29]
 LDCM0420  CL31 HEK-293T C162(1.07)  LDD1624  [29]
 LDCM0421  CL32 HEK-293T C162(1.34)  LDD1625  [29]
 LDCM0422  CL33 HEK-293T C162(0.66)  LDD1626  [29]
 LDCM0423  CL34 HEK-293T C162(1.01)  LDD1627  [29]
 LDCM0424  CL35 HEK-293T C162(1.52)  LDD1628  [29]
 LDCM0425  CL36 HEK-293T C162(1.03)  LDD1629  [29]
 LDCM0426  CL37 HEK-293T C162(1.64)  LDD1630  [29]
 LDCM0428  CL39 HEK-293T C162(1.26)  LDD1632  [29]
 LDCM0429  CL4 HEK-293T C162(0.84)  LDD1633  [29]
 LDCM0430  CL40 HEK-293T C162(1.26)  LDD1634  [29]
 LDCM0431  CL41 HEK-293T C162(1.56)  LDD1635  [29]
 LDCM0432  CL42 HEK-293T C162(1.04)  LDD1636  [29]
 LDCM0433  CL43 HEK-293T C162(1.14)  LDD1637  [29]
 LDCM0434  CL44 HEK-293T C162(1.25)  LDD1638  [29]
 LDCM0435  CL45 HEK-293T C162(0.90)  LDD1639  [29]
 LDCM0436  CL46 HEK-293T C162(0.89)  LDD1640  [29]
 LDCM0437  CL47 HEK-293T C162(1.36)  LDD1641  [29]
 LDCM0438  CL48 HEK-293T C162(1.11)  LDD1642  [29]
 LDCM0439  CL49 HEK-293T C162(1.03)  LDD1643  [29]
 LDCM0440  CL5 HEK-293T C162(1.12)  LDD1644  [29]
 LDCM0441  CL50 HEK-293T C162(1.00)  LDD1645  [29]
 LDCM0443  CL52 HEK-293T C162(0.99)  LDD1646  [29]
 LDCM0444  CL53 HEK-293T C162(1.30)  LDD1647  [29]
 LDCM0445  CL54 HEK-293T C162(0.97)  LDD1648  [29]
 LDCM0446  CL55 HEK-293T C162(1.10)  LDD1649  [29]
 LDCM0447  CL56 HEK-293T C162(1.36)  LDD1650  [29]
 LDCM0448  CL57 HEK-293T C162(0.85)  LDD1651  [29]
 LDCM0449  CL58 HEK-293T C162(1.08)  LDD1652  [29]
 LDCM0450  CL59 HEK-293T C162(1.42)  LDD1653  [29]
 LDCM0451  CL6 HEK-293T C162(0.87)  LDD1654  [29]
 LDCM0452  CL60 HEK-293T C162(1.07)  LDD1655  [29]
 LDCM0453  CL61 HEK-293T C162(1.80)  LDD1656  [29]
 LDCM0454  CL62 HEK-293T C162(1.05)  LDD1657  [29]
 LDCM0455  CL63 HEK-293T C162(0.93)  LDD1658  [29]
 LDCM0456  CL64 HEK-293T C162(1.12)  LDD1659  [29]
 LDCM0457  CL65 HEK-293T C162(1.43)  LDD1660  [29]
 LDCM0458  CL66 HEK-293T C162(1.13)  LDD1661  [29]
 LDCM0459  CL67 HEK-293T C162(1.13)  LDD1662  [29]
 LDCM0460  CL68 HEK-293T C162(1.43)  LDD1663  [29]
 LDCM0461  CL69 HEK-293T C162(0.73)  LDD1664  [29]
 LDCM0462  CL7 HEK-293T C162(1.10)  LDD1665  [29]
 LDCM0463  CL70 HEK-293T C162(1.29)  LDD1666  [29]
 LDCM0464  CL71 HEK-293T C162(1.44)  LDD1667  [29]
 LDCM0465  CL72 HEK-293T C162(1.33)  LDD1668  [29]
 LDCM0466  CL73 HEK-293T C162(1.00)  LDD1669  [29]
 LDCM0467  CL74 HEK-293T C162(0.86)  LDD1670  [29]
 LDCM0469  CL76 HEK-293T C162(1.11)  LDD1672  [29]
 LDCM0470  CL77 HEK-293T C162(1.05)  LDD1673  [29]
 LDCM0471  CL78 HEK-293T C162(0.89)  LDD1674  [29]
 LDCM0472  CL79 HEK-293T C162(1.04)  LDD1675  [29]
 LDCM0473  CL8 HEK-293T C162(0.70)  LDD1676  [29]
 LDCM0474  CL80 HEK-293T C162(0.79)  LDD1677  [29]
 LDCM0475  CL81 HEK-293T C162(0.81)  LDD1678  [29]
 LDCM0476  CL82 HEK-293T C162(0.84)  LDD1679  [29]
 LDCM0477  CL83 HEK-293T C162(1.08)  LDD1680  [29]
 LDCM0478  CL84 HEK-293T C162(0.91)  LDD1681  [29]
 LDCM0479  CL85 HEK-293T C162(1.08)  LDD1682  [29]
 LDCM0480  CL86 HEK-293T C162(0.90)  LDD1683  [29]
 LDCM0481  CL87 HEK-293T C162(1.03)  LDD1684  [29]
 LDCM0482  CL88 HEK-293T C162(1.08)  LDD1685  [29]
 LDCM0483  CL89 HEK-293T C162(1.17)  LDD1686  [29]
 LDCM0484  CL9 HEK-293T C162(0.59)  LDD1687  [29]
 LDCM0485  CL90 HEK-293T C162(1.07)  LDD1688  [29]
 LDCM0486  CL91 HEK-293T C162(1.20)  LDD1689  [29]
 LDCM0487  CL92 HEK-293T C162(1.48)  LDD1690  [29]
 LDCM0488  CL93 HEK-293T C162(0.93)  LDD1691  [29]
 LDCM0489  CL94 HEK-293T C162(1.11)  LDD1692  [29]
 LDCM0490  CL95 HEK-293T C162(1.31)  LDD1693  [29]
 LDCM0491  CL96 HEK-293T C162(0.98)  LDD1694  [29]
 LDCM0492  CL97 HEK-293T C162(0.96)  LDD1695  [29]
 LDCM0493  CL98 HEK-293T C162(0.90)  LDD1696  [29]
 LDCM0494  CL99 HEK-293T C162(0.84)  LDD1697  [29]
 LDCM0189  Compound 16 HEK-293T 12.82  LDD0492  [26]
 LDCM0185  Compound 17 HEK-293T 9.26  LDD0504  [26]
 LDCM0182  Compound 18 HEK-293T 5.35  LDD0501  [26]
 LDCM0184  Compound 20 HEK-293T 13.25  LDD0503  [26]
 LDCM0191  Compound 21 HEK-293T 11.30  LDD0493  [26]
 LDCM0187  Compound 32 HEK-293T 44.44  LDD0507  [26]
 LDCM0188  Compound 33 HEK-293T 4.49  LDD0505  [26]
 LDCM0190  Compound 34 HEK-293T 16.13  LDD0497  [26]
 LDCM0192  Compound 35 HEK-293T 7.69  LDD0491  [26]
 LDCM0193  Compound 36 HEK-293T 5.65  LDD0494  [26]
 LDCM0194  Compound 37 HEK-293T 9.30  LDD0498  [26]
 LDCM0196  Compound 39 HEK-293T 11.56  LDD0496  [26]
 LDCM0197  Compound 40 HEK-293T 15.50  LDD0495  [26]
 LDCM0634  CY-0357 Hep-G2 C162(0.98); C162(0.74)  LDD2228  [16]
 LDCM0028  Dobutamine HEK-293T 35.87  LDD0180  [5]
 LDCM0495  E2913 HEK-293T C162(1.28)  LDD1698  [29]
 LDCM0625  F8 Ramos C110(0.84); C162(1.07)  LDD2187  [30]
 LDCM0572  Fragment10 Ramos C110(2.14); C162(1.67)  LDD2189  [30]
 LDCM0573  Fragment11 Ramos C110(0.04)  LDD2190  [30]
 LDCM0574  Fragment12 Ramos C110(2.22); C162(0.84)  LDD2191  [30]
 LDCM0575  Fragment13 Ramos C110(2.59); C162(1.62)  LDD2192  [30]
 LDCM0576  Fragment14 Ramos C110(1.41); C162(0.73)  LDD2193  [30]
 LDCM0579  Fragment20 Ramos C110(3.53); C162(0.73)  LDD2194  [30]
 LDCM0580  Fragment21 Ramos C110(1.32); C162(1.07)  LDD2195  [30]
 LDCM0582  Fragment23 Ramos C110(3.06); C162(1.37)  LDD2196  [30]
 LDCM0578  Fragment27 Ramos C110(1.34); C162(1.17)  LDD2197  [30]
 LDCM0586  Fragment28 Ramos C110(0.84); C162(0.78)  LDD2198  [30]
 LDCM0588  Fragment30 Ramos C110(2.86); C162(1.69)  LDD2199  [30]
 LDCM0589  Fragment31 Ramos C110(1.87); C162(1.24)  LDD2200  [30]
 LDCM0590  Fragment32 Ramos C110(2.06); C162(1.52)  LDD2201  [30]
 LDCM0468  Fragment33 HEK-293T C162(0.97)  LDD1671  [29]
 LDCM0596  Fragment38 Ramos C110(1.63); C162(1.01)  LDD2203  [30]
 LDCM0566  Fragment4 Ramos C110(1.16); C162(0.81)  LDD2184  [30]
 LDCM0427  Fragment51 HEK-293T C162(1.23)  LDD1631  [29]
 LDCM0610  Fragment52 Ramos C110(2.41); C162(1.52)  LDD2204  [30]
 LDCM0614  Fragment56 Ramos C110(3.85); C162(2.07)  LDD2205  [30]
 LDCM0569  Fragment7 Ramos C110(1.34); C162(0.74)  LDD2186  [30]
 LDCM0571  Fragment9 Ramos C110(2.56); C162(1.30)  LDD2188  [30]
 LDCM0116  HHS-0101 DM93 Y141(0.89); Y102(1.12); Y129(1.14)  LDD0264  [8]
 LDCM0117  HHS-0201 DM93 Y141(0.75); Y102(0.86); Y129(1.13)  LDD0265  [8]
 LDCM0118  HHS-0301 DM93 Y102(0.64); Y141(1.04); Y129(1.22)  LDD0266  [8]
 LDCM0119  HHS-0401 DM93 Y141(0.50); Y102(0.71); Y129(1.49)  LDD0267  [8]
 LDCM0120  HHS-0701 DM93 Y141(0.67); Y102(1.01); Y129(2.08)  LDD0268  [8]
 LDCM0107  IAA HeLa H38(0.00); H51(0.00)  LDD0221  [22]
 LDCM0125  JWB146 DM93 Y129(3.26)  LDD0287  [7]
 LDCM0126  JWB150 DM93 Y129(3.77)  LDD0288  [7]
 LDCM0127  JWB152 DM93 Y129(5.12)  LDD0289  [7]
 LDCM0128  JWB198 DM93 Y129(1.77)  LDD0290  [7]
 LDCM0129  JWB202 DM93 Y129(1.03)  LDD0291  [7]
 LDCM0130  JWB211 DM93 Y129(2.20)  LDD0292  [7]
 LDCM0073  Kambe_cp3 PC-3 20.00  LDD0125  [27]
 LDCM0076  kambe_cp71 PC-3 4.29  LDD0132  [27]
 LDCM0022  KB02 HCT 116 C162(1.45)  LDD0080  [10]
 LDCM0023  KB03 HCT 116 C162(1.14)  LDD0081  [10]
 LDCM0024  KB05 HCT 116 C162(1.19)  LDD0082  [10]
 LDCM0109  NEM HeLa H51(0.00); H38(0.00); H132(0.00)  LDD0223  [22]
 LDCM0627  NUDT7-COV-1 HEK-293T C110(0.67)  LDD2206  [31]
 LDCM0628  OTUB2-COV-1 HEK-293T C110(1.14)  LDD2207  [31]
 LDCM0029  Quercetin HEK-293T 47.66  LDD0181  [5]
 LDCM0131  RA190 MM1.R C162(1.16)  LDD0304  [32]
 LDCM0113  W17 Hep-G2 E48(1.51); Q49(1.51)  LDD0240  [23]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Maspardin (SPG21) AB hydrolase superfamily Q9NZD8
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
Proteasome subunit alpha type-1 (PSMA1) Peptidase T1A family P25786
dCTP pyrophosphatase 1 (DCTPP1) . Q9H773
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Syntenin-1 (SDCBP) . O00560
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA damage-inducible transcript 4-like protein (DDIT4L) DDIT4 family Q96D03

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomics and Phosphoproteomics Profiling Reveals Salvianolic Acid A as a Covalent Inhibitor of mTORC1. J Proteome Res. 2023 Jul 7;22(7):2450-2459. doi: 10.1021/acs.jproteome.3c00188. Epub 2023 Jun 22.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
8 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
9 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
12 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
13 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
14 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
15 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
16 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
17 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
18 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
19 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
20 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
21 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
22 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
23 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
24 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
25 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
26 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
27 Mapping the protein interaction landscape for fully functionalized small-molecule probes in human cells. J Am Chem Soc. 2014 Jul 30;136(30):10777-82. doi: 10.1021/ja505517t. Epub 2014 Jul 21.
28 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
29 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
30 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
31 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
32 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.