Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C197  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 76 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP09256  Putative phospholipase B-like 2 (PLBD2) 26.9
 LDTP12732  Hypoxia-inducible factor 1-alpha inhibitor (HIF1AN) 22.2
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 21.9
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 20.7
 LDTP02223  Cathepsin B (CTSB) 19.8
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 18.9
 LDTP00316  Ribonuclease T2 (RNASET2) 18.3
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 17.6
 LDTP02141  Alpha-galactosidase A (GLA) 17.5
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 15.9
 LDTP10888  Legumain (LGMN) 15.8
 LDTP02799  N-acetylglucosamine-6-sulfatase (GNS) 15.7
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 14.3
 LDTP11215  Plasma alpha-L-fucosidase (FUCA2) 13.9
 LDTP09395  Signal peptide peptidase-like 2A (SPPL2A) 13.5
 LDTP16007  Lipid droplet-associated hydrolase (LDAH) 12.9
 LDTP00185  Deoxyribonuclease-2-alpha (DNASE2) 12.7
 LDTP12628  Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) 12.5
 LDTP02169  Beta-hexosaminidase subunit alpha (HEXA) 12.3
 LDTP01372  Carboxypeptidase D (CPD) 12.2
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 11.7
 LDTP02837  Beta-galactosidase (GLB1) 11.6
 LDTP00282  Beta-mannosidase (MANBA) 11.0
 LDTP10318  Ubiquitin thioesterase OTUB1 (OTUB1) 10.7
 LDTP00697  Cytochrome b5 type B (CYB5B) 10.5
 LDTP02539  Lysosomal acid phosphatase (ACP2) 10.3
 LDTP06617  Ceramide glucosyltransferase (UGCG) 9.9
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 9.8
 LDTP04634  Alpha-N-acetylglucosaminidase (NAGLU) 9.8
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 9.6
 LDTP15422  Prostaglandin reductase 3 (PTGR3) 9.5
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 9.4
 LDTP13131  7-dehydrocholesterol reductase (DHCR7) 9.3
 LDTP00428  Tripeptidyl-peptidase 1 (TPP1) 9.3
 LDTP03541  Adenylosuccinate synthetase isozyme 2 (ADSS2) 9.1
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 8.8
 LDTP02505  Lysosomal protective protein (CTSA) 8.5
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 8.5
 LDTP09088  Phospholipase A2 group XV (PLA2G15) 8.5
 LDTP06618  ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) 8.3
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 8.2
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 8.2
 LDTP09886  Gamma-glutamyl hydrolase (GGH) 8.0
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 7.9
 LDTP04572  Dipeptidyl peptidase 1 (CTSC) 7.8
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 7.8
 LDTP02006  Tissue alpha-L-fucosidase (FUCA1) 7.8
 LDTP03417  Proteasome subunit beta type-4 (PSMB4) 7.7
 LDTP00783  Beta-1,4-glucuronyltransferase 1 (B4GAT1) 7.4
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 7.3
 LDTP02486  Lysosomal alpha-glucosidase (GAA) 7.2
 LDTP14030  V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) 7.2
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 7.1
 LDTP06307  Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1) 6.9
 LDTP05476  3-ketodihydrosphingosine reductase (KDSR) 6.8
 LDTP02216  Beta-hexosaminidase subunit beta (HEXB) 6.8
 LDTP14218  Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) 6.7
 LDTP04211  Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) 6.3
 LDTP05905  Acid ceramidase (ASAH1) 6.2
 LDTP08265  N-alpha-acetyltransferase 40 (NAA40) 6.2
 LDTP12610  Obg-like ATPase 1 (OLA1) 6.2
 LDTP06370  Ephrin type-A receptor 7 (EPHA7) 6.1
 LDTP07813  Sulfhydryl oxidase 2 (QSOX2) 6.1
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 5.8
 LDTP13620  Lysosomal thioesterase PPT2 (PPT2) 5.8
 LDTP07003  Presequence protease, mitochondrial (PITRM1) 5.7
 LDTP09063  Estradiol 17-beta-dehydrogenase 11 (HSD17B11) 5.6
 LDTP10032  7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) 5.6
 LDTP01333  Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) 5.5
 LDTP14801  Di-N-acetylchitobiase (CTBS) 5.4
 LDTP13751  Exonuclease 1 (EXO1) 5.3
 LDTP01640  CCR4-NOT transcription complex subunit 4 (CNOT4) 5.1
 LDTP03060  Proteasome subunit beta type-1 (PSMB1) 5.1
 LDTP00496  Long-chain fatty acid transport protein 2 (SLC27A2) 5.0
 LDTP12720  Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) 5.0
 LDTP01329  Lathosterol oxidase (SC5D) 4.9
Transporter and channel
Click to Show/Hide to Show 51 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 26.0
 LDTP02215  Prosaposin (PSAP) 16.7
 LDTP02071  Amyloid-beta precursor protein (APP) 16.2
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 15.6
 LDTP16813  Tetraspanin-3 (TSPAN3) 15.1
 LDTP11615  Protein tweety homolog 3 (TTYH3) 15.0
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 13.5
 LDTP02586  Cation-independent mannose-6-phosphate receptor (IGF2R) 12.1
 LDTP12451  Integral membrane protein 2C (ITM2C) 12.0
 LDTP07236  Protein GPR107 (GPR107) 11.7
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 11.5
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 11.1
 LDTP04940  NPC intracellular cholesterol transporter 2 (NPC2) 11.0
 LDTP15948  Transmembrane protein 126A (TMEM126A) 10.9
 LDTP17362  Magnesium transporter NIPA3 (NIPAL1) 10.7
 LDTP04459  H(+)/Cl(-) exchange transporter 3 (CLCN3) 10.6
 LDTP03380  Stomatin (STOM) 10.6
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 9.8
 LDTP09968  V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) 9.6
 LDTP12383  Protein GPR108 (GPR108) 9.1
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 9.1
 LDTP20002  Transmembrane protein 160 (TMEM160) 9.0
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 8.9
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 8.9
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 8.7
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 8.5
 LDTP05116  CMP-sialic acid transporter (SLC35A1) 8.2
 LDTP06581  Occludin (OCLN) 7.9
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 7.8
 LDTP15733  Solute carrier family 25 member 44 (SLC25A44) 7.7
 LDTP10885  Sortilin (SORT1) 7.4
 LDTP02562  Lysosome-associated membrane glycoprotein 1 (LAMP1) 7.2
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 7.2
 LDTP01969  Transferrin receptor protein 1 (TFRC) 7.1
 LDTP08881  Transmembrane protein 199 (TMEM199) 7.1
 LDTP15000  Solute carrier family 35 member F1 (SLC35F1) 7.1
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 6.9
 LDTP16069  Peroxisomal membrane protein 2 (PXMP2) 6.7
 LDTP00541  NPC intracellular cholesterol transporter 1 (NPC1) 6.6
 LDTP18459  StAR-related lipid transfer protein 7, mitochondrial (STARD7) 6.6
 LDTP06499  V-type proton ATPase subunit S1 (ATP6AP1) 6.4
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 6.3
 LDTP09328  Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) 6.2
 LDTP01427  Slit homolog 2 protein (SLIT2) 6.1
 LDTP17641  Solute carrier family 35 member F2 (SLC35F2) 6.0
 LDTP03546  Translocator protein (TSPO) 5.8
 LDTP00592  Surfeit locus protein 4 (SURF4) 5.5
 LDTP14200  Mitochondrial ornithine transporter 1 (SLC25A15) 5.4
 LDTP16190  Protein FAM8A1 (FAM8A1) 5.4
 LDTP05900  Metaxin-1 (MTX1) 5.3
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 5.3
Immunoglobulin
Click to Show/Hide to Show 3 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02491  HLA class I histocompatibility antigen, C alpha chain (HLA-C) 7.8
 LDTP04720  IgG receptor FcRn large subunit p51 (FCGRT) 7.6
 LDTP01913  HLA class I histocompatibility antigen, B alpha chain (HLA-B) 5.1
Other
Click to Show/Hide to Show 37 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP13606  Mammalian ependymin-related protein 1 (EPDR1) 23.1
 LDTP14458  Tetraspanin-6 (TSPAN6) 17.9
 LDTP11076  Apolipoprotein L2 (APOL2) 17.5
 LDTP05160  Nucleobindin-2 (NUCB2) 17.4
 LDTP08689  Dyslexia-associated protein KIAA0319-like protein (KIAA0319L) 15.1
 LDTP05558  Galectin-3-binding protein (LGALS3BP) 12.3
 LDTP19780  Keratinocyte-associated transmembrane protein 2 (KCT2) 11.6
 LDTP08796  Protein SYS1 homolog (SYS1) 10.3
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 10.0
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 9.1
 LDTP05491  Amyloid beta precursor like protein 2 (APLP2) 8.8
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 8.6
 LDTP09920  Golgi apparatus protein 1 (GLG1) 8.5
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 7.7
 LDTP07031  Collectin-12 (COLEC12) 7.6
 LDTP06154  Desmocollin-3 (DSC3) 7.5
 LDTP02927  Ganglioside GM2 activator (GM2A) 7.4
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 7.2
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 6.8
 LDTP18561  Small ribosomal subunit protein mS33 (MRPS33) 6.6
 LDTP12623  Zinc finger CCHC domain-containing protein 3 (ZCCHC3) 6.6
 LDTP09787  Nicastrin (NCSTN) 6.5
 LDTP05375  Nucleobindin-1 (NUCB1) 6.5
 LDTP00105  Protein unc-119 homolog B (UNC119B) 6.5
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 6.0
 LDTP06097  Reticulocalbin-2 (RCN2) 5.5
 LDTP05898  Sequestosome-1 (SQSTM1) 5.5
 LDTP00887  Calumenin (CALU) 5.5
 LDTP05318  RNA-binding protein EWS (EWSR1) 5.4
 LDTP03775  RNA-binding protein FUS (FUS) 5.3
 LDTP07368  Tetratricopeptide repeat protein 19, mitochondrial (TTC19) 5.2
 LDTP05501  Fragile X messenger ribonucleoprotein 1 (FMR1) 5.2
 LDTP06735  Cytoplasmic tRNA 2-thiolation protein 2 (CTU2) 5.1
 LDTP06042  Desmoglein-2 (DSG2) 5.1
 LDTP04652  Eukaryotic translation initiation factor 5 (EIF5) 5.0
 LDTP08594  Negative elongation factor C/D (NELFCD) 5.0
 LDTP17266  Pre-mRNA-splicing factor 38B (PRPF38B) 5.0

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587