Details of the Target

General Information of Target

Target ID LDTP07003
Target Name Presequence protease, mitochondrial (PITRM1)
Gene Name PITRM1
Gene ID 10531
Synonyms
KIAA1104; MP1; PREP; Presequence protease, mitochondrial; hPreP; EC 3.4.24.-; Pitrilysin metalloproteinase 1; Metalloprotease 1; hMP1
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MWRCGGRQGLCVLRRLSGGHAHHRAWRWNSNRACERALQYKLGDKIHGFTVNQVTSVPEL
FLTAVKLTHDDTGARYLHLAREDTNNLFSVQFRTTPMDSTGVPHILEHTVLCGSQKYPCR
DPFFKMLNRSLSTFMNAFTASDYTLYPFSTQNPKDFQNLLSVYLDATFFPCLRELDFWQE
GWRLEHENPSDPQTPLVFKGVVFNEMKGAFTDNERIFSQHLQNRLLPDHTYSVVSGGDPL
CIPELTWEQLKQFHATHYHPSNARFFTYGNFPLEQHLKQIHEEALSKFQKIEPSTVVPAQ
TPWDKPREFQITCGPDSFATDPSKQTTISVSFLLPDITDTFEAFTLSLLSSLLTSGPNSP
FYKALIESGLGTDFSPDVGYNGYTREAYFSVGLQGIAEKDIETVRSLIDRTIDEVVEKGF
EDDRIEALLHKIEIQMKHQSTSFGLMLTSYIASCWNHDGDPVELLKLGNQLAKFRQCLQE
NPKFLQEKVKQYFKNNQHKLTLSMRPDDKYHEKQAQVEATKLKQKVEALSPGDRQQIYEK
GLELRSQQSKPQDASCLPALKVSDIEPTIPVTELDVVLTAGDIPVQYCAQPTNGMVYFRA
FSSLNTLPEELRPYVPLFCSVLTKLGCGLLDYREQAQQIELKTGGMSASPHVLPDDSHMD
TYEQGVLFSSLCLDRNLPDMMQLWSEIFNNPCFEEEEHFKVLVKMTAQELANGIPDSGHL
YASIRAGRTLTPAGDLQETFSGMDQVRLMKRIAEMTDIKPILRKLPRIKKHLLNGDNMRC
SVNATPQQMPQTEKAVEDFLRSIGRSKKERRPVRPHTVEKPVPSSSGGDAHVPHGSQVIR
KLVMEPTFKPWQMKTHFLMPFPVNYVGECIRTVPYTDPDHASLKILARLMTAKFLHTEIR
EKGGAYGGGAKLSHNGIFTLYSYRDPNTIETLQSFGKAVDWAKSGKFTQQDIDEAKLSVF
STVDAPVAPSDKGMDHFLYGLSDEMKQAHREQLFAVSHDKLLAVSDRYLGTGKSTHGLAI
LGPENPKIAKDPSWIIQ
Target Bioclass
Enzyme
Family
Peptidase M16 family, PreP subfamily
Subcellular location
Mitochondrion
Function
Metalloendopeptidase of the mitochondrial matrix that functions in peptide cleavage and degradation rather than in protein processing. Has an ATP-independent activity. Specifically cleaves peptides in the range of 5 to 65 residues. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference. Degrades the transit peptides of mitochondrial proteins after their cleavage. Also degrades other unstructured peptides. It is also able to degrade amyloid-beta protein 40, one of the peptides produced by APP processing, when it accumulates in mitochondrion. It is a highly efficient protease, at least toward amyloid-beta protein 40. Cleaves that peptide at a specific position and is probably not processive, releasing digested peptides intermediates that can be further cleaved subsequently. It is also able to degrade amyloid-beta protein 42.
Uniprot ID
Q5JRX3
Ensemble ID
ENST00000224949.9
HGNC ID
HGNC:17663
ChEMBL ID
CHEMBL3124731

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
8305C SNV: p.D238N DBIA    Probe Info 
CAL72 Insertion: p.Q91PfsTer7 DBIA    Probe Info 
MFE296 SNV: p.F598L DBIA    Probe Info 
P31FUJ SNV: p.G5C DBIA    Probe Info 
RKO SNV: p.R264M; p.M749V DBIA    Probe Info 
SUPT1 SNV: p.Q275H DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 34 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Alkylaryl probe 1
 Probe Info  		12.00  LDD0387  [1]
N1
 Probe Info  		100.00  LDD0242  [2]
TH211
 Probe Info  		Y383(20.00); Y923(11.50); Y979(7.57); Y921(5.34)  LDD0257  [3]
TH214
 Probe Info  		Y383(20.00)  LDD0258  [3]
TH216
 Probe Info  		Y383(20.00); Y538(11.78)  LDD0259  [3]
STPyne
 Probe Info  		K1027(9.47); K770(4.71)  LDD0277  [4]
DBIA
 Probe Info  		C627(1.48)  LDD3310  [5]
BTD
 Probe Info  		C556(1.46)  LDD1700  [6]
Johansson_61
 Probe Info  		_(20.00)  LDD1490  [7]
YY4-yne
 Probe Info  		3.59  LDD0400  [8]
AHL-Pu-1
 Probe Info  		C869(4.89)  LDD0168  [9]
HHS-482
 Probe Info  		Y921(0.29)  LDD0286  [10]
HHS-475
 Probe Info  		Y921(0.37); Y979(0.45); Y614(1.07)  LDD0264  [11]
ATP probe
 Probe Info  		N.A.  LDD0199  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		C619(0.00); C780(0.00); C313(0.00); C627(0.00)  LDD0038  [13]
IA-alkyne
 Probe Info  		C556(0.00); C869(0.00); C241(0.00); C627(0.00)  LDD0032  [14]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [15]
Lodoacetamide azide
 Probe Info  		C619(0.00); C780(0.00); C313(0.00); C454(0.00)  LDD0037  [13]
ATP probe
 Probe Info  		N.A.  LDD0035  [16]
NAIA_4
 Probe Info  		C619(0.00); C692(0.00)  LDD2226  [17]
ENE
 Probe Info  		N.A.  LDD0006  [18]
IPM
 Probe Info  		N.A.  LDD0005  [18]
PPMS
 Probe Info  		N.A.  LDD0008  [18]
SF
 Probe Info  		N.A.  LDD0028  [19]
TFBX
 Probe Info  		C556(0.00); C627(0.00); C477(0.00)  LDD0148  [20]
VSF
 Probe Info  		N.A.  LDD0007  [18]
Phosphinate-6
 Probe Info  		C556(0.00); C119(0.00)  LDD0018  [21]
1c-yne
 Probe Info  		N.A.  LDD0228  [22]
Acrolein
 Probe Info  		C313(0.00); C556(0.00); C869(0.00)  LDD0217  [23]
Crotonaldehyde
 Probe Info  		C627(0.00); C313(0.00)  LDD0219  [23]
Methacrolein
 Probe Info  		N.A.  LDD0218  [23]
m-APA
 Probe Info  		N.A.  LDD0404  [24]
NAIA_5
 Probe Info  		C619(0.00); C780(0.00); C171(0.00); C477(0.00)  LDD2223  [17]
HHS-465
 Probe Info  		K937(0.00); Y383(0.00); Y921(0.00); K624(0.00)  LDD2240  [25]
PAL-AfBPP Probe
Click To Hide/Show 60 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		9.51  LDD1714  [26]
C017
 Probe Info  		12.55  LDD1725  [26]
C027
 Probe Info  		6.41  LDD1733  [26]
C055
 Probe Info  		13.83  LDD1752  [26]
C087
 Probe Info  		7.52  LDD1779  [26]
C108
 Probe Info  		9.78  LDD1795  [26]
C139
 Probe Info  		10.78  LDD1821  [26]
C153
 Probe Info  		22.32  LDD1834  [26]
C158
 Probe Info  		14.03  LDD1838  [26]
C163
 Probe Info  		13.74  LDD1843  [26]
C178
 Probe Info  		19.56  LDD1857  [26]
C187
 Probe Info  		24.25  LDD1865  [26]
C191
 Probe Info  		25.11  LDD1868  [26]
C193
 Probe Info  		6.41  LDD1869  [26]
C195
 Probe Info  		6.68  LDD1871  [26]
C197
 Probe Info  		5.66  LDD1873  [26]
C198
 Probe Info  		10.34  LDD1874  [26]
C206
 Probe Info  		18.25  LDD1881  [26]
C218
 Probe Info  		16.00  LDD1892  [26]
C219
 Probe Info  		5.21  LDD1893  [26]
C228
 Probe Info  		15.24  LDD1901  [26]
C234
 Probe Info  		6.68  LDD1907  [26]
C235
 Probe Info  		16.80  LDD1908  [26]
C239
 Probe Info  		5.58  LDD1912  [26]
C244
 Probe Info  		13.83  LDD1917  [26]
C252
 Probe Info  		8.46  LDD1925  [26]
C277
 Probe Info  		20.53  LDD1947  [26]
C282
 Probe Info  		16.56  LDD1952  [26]
C293
 Probe Info  		21.71  LDD1963  [26]
C299
 Probe Info  		6.32  LDD1968  [26]
C313
 Probe Info  		12.82  LDD1980  [26]
C322
 Probe Info  		5.90  LDD1988  [26]
C326
 Probe Info  		10.85  LDD1990  [26]
C338
 Probe Info  		15.35  LDD2001  [26]
C339
 Probe Info  		6.02  LDD2002  [26]
C343
 Probe Info  		17.15  LDD2005  [26]
C348
 Probe Info  		19.29  LDD2009  [26]
C349
 Probe Info  		9.13  LDD2010  [26]
C350
 Probe Info  		25.99  LDD2011  [26]
C353
 Probe Info  		11.88  LDD2014  [26]
C362
 Probe Info  		25.63  LDD2023  [26]
C376
 Probe Info  		13.27  LDD2036  [26]
C390
 Probe Info  		28.44  LDD2049  [26]
C407
 Probe Info  		16.34  LDD2064  [26]
C413
 Probe Info  		14.83  LDD2069  [26]
C431
 Probe Info  		16.68  LDD2086  [26]
FFF probe11
 Probe Info  		20.00  LDD0471  [27]
FFF probe13
 Probe Info  		20.00  LDD0475  [27]
FFF probe14
 Probe Info  		12.57  LDD0477  [27]
FFF probe15
 Probe Info  		5.58  LDD0478  [27]
FFF probe2
 Probe Info  		20.00  LDD0463  [27]
FFF probe3
 Probe Info  		11.38  LDD0464  [27]
FFF probe6
 Probe Info  		7.34  LDD0467  [27]
JN0003
 Probe Info  		16.52  LDD0469  [27]
STS-2
 Probe Info  		N.A.  LDD0139  [28]
A-DA
 Probe Info  		2.06  LDD0141  [29]
Kambe_31
 Probe Info  		5.29  LDD0135  [30]
BD-F
 Probe Info  		Y380(0.00); D377(0.00); V378(0.00); G382(0.00)  LDD0024  [31]
LD-F
 Probe Info  		S375(0.00); G382(0.00); F374(0.00)  LDD0015  [31]
OEA-DA
 Probe Info  		17.72  LDD0046  [32]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C556(0.64)  LDD2112  [6]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C556(0.70)  LDD2095  [6]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C556(0.81)  LDD2130  [6]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C556(1.11); C477(0.96)  LDD2117  [6]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C556(1.20)  LDD2152  [6]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C556(1.04)  LDD2103  [6]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C556(0.54)  LDD2132  [6]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C556(0.69)  LDD2131  [6]
 LDCM0025  4SU-RNA HEK-293T C869(4.89)  LDD0168  [9]
 LDCM0026  4SU-RNA+native RNA HEK-293T C869(2.49)  LDD0169  [9]
 LDCM0214  AC1 HEK-293T C477(0.95); C556(1.01); C627(0.99); C313(0.99)  LDD1507  [33]
 LDCM0215  AC10 HEK-293T C477(0.83); C556(0.97); C627(0.95); C313(0.79)  LDD1508  [33]
 LDCM0226  AC11 HEK-293T C477(0.98); C556(0.98); C627(0.93); C313(0.88)  LDD1509  [33]
 LDCM0237  AC12 HEK-293T C477(0.94); C556(0.96); C627(0.93); C313(0.91)  LDD1510  [33]
 LDCM0259  AC14 HEK-293T C477(1.16); C556(0.98); C627(0.95); C313(0.95)  LDD1512  [33]
 LDCM0270  AC15 HEK-293T C477(1.13); C556(0.94); C627(1.03); C313(0.98)  LDD1513  [33]
 LDCM0276  AC17 HEK-293T C477(0.99); C556(0.98); C627(0.88); C313(1.01)  LDD1515  [33]
 LDCM0277  AC18 HEK-293T C477(0.95); C556(0.94); C627(0.94); C313(0.91)  LDD1516  [33]
 LDCM0278  AC19 HEK-293T C477(0.91); C556(1.07); C627(0.87); C313(0.98)  LDD1517  [33]
 LDCM0279  AC2 HEK-293T C477(0.98); C556(1.04); C627(0.91); C313(0.92)  LDD1518  [33]
 LDCM0280  AC20 HEK-293T C477(1.04); C556(0.95); C627(0.95); C313(1.08)  LDD1519  [33]
 LDCM0281  AC21 HEK-293T C477(0.93); C556(0.99); C627(1.02); C313(1.03)  LDD1520  [33]
 LDCM0282  AC22 HEK-293T C477(0.95); C556(0.97); C627(1.03); C313(1.00)  LDD1521  [33]
 LDCM0283  AC23 HEK-293T C477(1.11); C556(0.98); C627(1.03); C313(0.90)  LDD1522  [33]
 LDCM0284  AC24 HEK-293T C477(0.95); C556(1.01); C627(0.94); C313(0.92)  LDD1523  [33]
 LDCM0285  AC25 HEK-293T C477(0.94); C556(1.00); C627(0.99); C313(1.01)  LDD1524  [33]
 LDCM0286  AC26 HEK-293T C477(1.05); C556(0.96); C627(0.96); C313(0.83)  LDD1525  [33]
 LDCM0287  AC27 HEK-293T C477(1.16); C556(0.96); C627(0.91); C313(0.97)  LDD1526  [33]
 LDCM0288  AC28 HEK-293T C477(0.96); C556(0.94); C627(0.95); C313(1.02)  LDD1527  [33]
 LDCM0289  AC29 HEK-293T C477(1.07); C556(0.97); C627(0.99); C313(0.94)  LDD1528  [33]
 LDCM0290  AC3 HEK-293T C477(1.05); C556(1.01); C627(0.91); C313(0.91)  LDD1529  [33]
 LDCM0291  AC30 HEK-293T C477(0.94); C556(0.98); C627(1.02); C313(1.00)  LDD1530  [33]
 LDCM0292  AC31 HEK-293T C477(0.96); C556(0.99); C627(0.97); C313(0.90)  LDD1531  [33]
 LDCM0293  AC32 HEK-293T C477(1.01); C556(0.99); C627(0.94); C313(1.17)  LDD1532  [33]
 LDCM0294  AC33 HEK-293T C477(1.03); C556(0.98); C627(0.87); C313(0.96)  LDD1533  [33]
 LDCM0295  AC34 HEK-293T C477(1.05); C556(0.94); C627(0.92); C313(0.91)  LDD1534  [33]
 LDCM0296  AC35 HEK-293T C477(1.01); C556(0.94); C627(0.87); C313(0.91)  LDD1535  [33]
 LDCM0297  AC36 HEK-293T C477(0.95); C556(0.90); C627(0.95); C313(0.84)  LDD1536  [33]
 LDCM0298  AC37 HEK-293T C477(0.90); C556(1.01); C627(0.97); C313(0.94)  LDD1537  [33]
 LDCM0299  AC38 HEK-293T C477(0.86); C556(0.94); C627(1.05); C313(0.94)  LDD1538  [33]
 LDCM0300  AC39 HEK-293T C477(0.85); C556(0.97); C627(1.01); C313(0.91)  LDD1539  [33]
 LDCM0301  AC4 HEK-293T C477(0.94); C556(0.97); C627(1.02); C313(0.87)  LDD1540  [33]
 LDCM0302  AC40 HEK-293T C477(0.92); C556(0.95); C627(0.97); C313(0.95)  LDD1541  [33]
 LDCM0303  AC41 HEK-293T C477(0.95); C556(0.94); C627(0.88); C313(1.05)  LDD1542  [33]
 LDCM0304  AC42 HEK-293T C477(0.99); C556(0.92); C627(0.94); C313(0.94)  LDD1543  [33]
 LDCM0305  AC43 HEK-293T C477(0.88); C556(0.93); C627(0.92); C313(0.73)  LDD1544  [33]
 LDCM0306  AC44 HEK-293T C477(1.00); C556(0.92); C627(0.98); C313(0.96)  LDD1545  [33]
 LDCM0307  AC45 HEK-293T C477(0.90); C556(0.97); C627(0.93); C313(1.01)  LDD1546  [33]
 LDCM0308  AC46 HEK-293T C477(0.98); C556(0.98); C627(0.99); C313(0.87)  LDD1547  [33]
 LDCM0309  AC47 HEK-293T C477(0.94); C556(0.94); C627(1.05); C313(1.01)  LDD1548  [33]
 LDCM0310  AC48 HEK-293T C477(0.95); C556(0.98); C627(0.91); C313(1.03)  LDD1549  [33]
 LDCM0311  AC49 HEK-293T C477(0.97); C556(1.01); C627(0.91); C313(0.94)  LDD1550  [33]
 LDCM0312  AC5 HEK-293T C477(0.92); C556(1.10); C627(0.93); C313(1.02)  LDD1551  [33]
 LDCM0313  AC50 HEK-293T C477(0.98); C556(0.99); C627(0.91); C313(0.88)  LDD1552  [33]
 LDCM0314  AC51 HEK-293T C477(0.85); C556(0.98); C627(0.88); C313(0.79)  LDD1553  [33]
 LDCM0315  AC52 HEK-293T C477(0.95); C556(0.96); C627(0.95); C313(0.97)  LDD1554  [33]
 LDCM0316  AC53 HEK-293T C477(0.92); C556(1.01); C627(1.00); C313(0.96)  LDD1555  [33]
 LDCM0317  AC54 HEK-293T C477(0.97); C556(1.00); C627(1.04); C313(0.96)  LDD1556  [33]
 LDCM0318  AC55 HEK-293T C477(0.97); C556(0.99); C627(0.97); C313(0.96)  LDD1557  [33]
 LDCM0319  AC56 HEK-293T C477(0.90); C556(0.95); C627(0.93); C313(0.98)  LDD1558  [33]
 LDCM0320  AC57 HEK-293T C477(1.09); C556(0.94); C627(0.89); C313(0.95)  LDD1559  [33]
 LDCM0321  AC58 HEK-293T C477(0.88); C556(0.95); C627(0.92); C313(0.95)  LDD1560  [33]
 LDCM0322  AC59 HEK-293T C477(0.93); C556(0.98); C627(0.89); C313(0.86)  LDD1561  [33]
 LDCM0323  AC6 HEK-293T C477(0.84); C556(0.99); C627(1.02); C313(1.03)  LDD1562  [33]
 LDCM0324  AC60 HEK-293T C477(0.94); C556(0.91); C627(0.90); C313(0.78)  LDD1563  [33]
 LDCM0325  AC61 HEK-293T C477(0.80); C556(0.95); C627(0.94); C313(0.97)  LDD1564  [33]
 LDCM0326  AC62 HEK-293T C477(0.96); C556(0.97); C627(1.01); C313(0.89)  LDD1565  [33]
 LDCM0327  AC63 HEK-293T C477(0.95); C556(0.88); C627(0.97); C313(0.95)  LDD1566  [33]
 LDCM0328  AC64 HEK-293T C477(0.96); C556(0.97); C627(1.00); C313(0.88)  LDD1567  [33]
 LDCM0334  AC7 HEK-293T C477(0.98); C556(1.04); C627(0.94); C313(0.92)  LDD1568  [33]
 LDCM0345  AC8 HEK-293T C477(0.87); C556(0.99); C627(1.00); C313(0.96)  LDD1569  [33]
 LDCM0545  Acetamide MDA-MB-231 C556(0.54)  LDD2138  [6]
 LDCM0520  AKOS000195272 MDA-MB-231 C477(0.72)  LDD2113  [6]
 LDCM0248  AKOS034007472 HEK-293T C477(0.83); C556(1.02); C627(0.95); C313(1.01)  LDD1511  [33]
 LDCM0356  AKOS034007680 HEK-293T C477(0.98); C556(0.96); C627(0.92); C313(0.92)  LDD1570  [33]
 LDCM0275  AKOS034007705 HEK-293T C477(0.96); C556(0.97); C627(0.97); C313(1.01)  LDD1514  [33]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0404  [24]
 LDCM0498  BS-3668 MDA-MB-231 C556(0.59)  LDD2091  [6]
 LDCM0108  Chloroacetamide HeLa C313(0.00); C869(0.00); C241(0.00); C556(0.00)  LDD0222  [23]
 LDCM0632  CL-Sc Hep-G2 C556(20.00)  LDD2227  [17]
 LDCM0367  CL1 HEK-293T C477(1.02); C556(0.90); C627(0.89); C313(1.08)  LDD1571  [33]
 LDCM0368  CL10 HEK-293T C477(0.95); C556(0.72); C627(0.93); C313(1.01)  LDD1572  [33]
 LDCM0369  CL100 HEK-293T C477(0.87); C556(0.94); C627(0.94); C313(0.98)  LDD1573  [33]
 LDCM0370  CL101 HEK-293T C477(1.01); C556(0.98); C627(0.85); C313(0.98)  LDD1574  [33]
 LDCM0371  CL102 HEK-293T C477(0.84); C556(0.88); C627(0.97); C313(0.88)  LDD1575  [33]
 LDCM0372  CL103 HEK-293T C477(1.07); C556(0.94); C627(0.93); C313(1.01)  LDD1576  [33]
 LDCM0373  CL104 HEK-293T C477(0.91); C556(0.95); C627(0.91); C313(1.03)  LDD1577  [33]
 LDCM0374  CL105 HEK-293T C477(1.07); C556(0.95); C627(0.94); C313(0.94)  LDD1578  [33]
 LDCM0375  CL106 HEK-293T C477(0.87); C556(0.94); C627(0.96); C313(0.99)  LDD1579  [33]
 LDCM0376  CL107 HEK-293T C477(1.04); C556(1.04); C627(1.08); C313(1.02)  LDD1580  [33]
 LDCM0377  CL108 HEK-293T C477(0.91); C556(0.94); C627(0.97); C313(1.01)  LDD1581  [33]
 LDCM0378  CL109 HEK-293T C477(1.06); C556(0.92); C627(0.88); C313(1.09)  LDD1582  [33]
 LDCM0379  CL11 HEK-293T C477(1.04); C556(0.93); C627(1.03); C313(1.05)  LDD1583  [33]
 LDCM0380  CL110 HEK-293T C477(0.96); C556(0.87); C627(1.05); C313(1.12)  LDD1584  [33]
 LDCM0381  CL111 HEK-293T C477(0.98); C556(0.96); C627(1.01); C313(1.01)  LDD1585  [33]
 LDCM0382  CL112 HEK-293T C477(0.92); C556(0.94); C627(0.91); C313(1.40)  LDD1586  [33]
 LDCM0383  CL113 HEK-293T C477(1.04); C556(1.02); C627(0.88); C313(1.04)  LDD1587  [33]
 LDCM0384  CL114 HEK-293T C477(0.85); C556(0.85); C627(0.79); C313(0.85)  LDD1588  [33]
 LDCM0385  CL115 HEK-293T C477(0.97); C556(0.95); C627(0.98); C313(1.10)  LDD1589  [33]
 LDCM0386  CL116 HEK-293T C477(0.79); C556(0.96); C627(0.87); C313(1.00)  LDD1590  [33]
 LDCM0387  CL117 HEK-293T C477(0.94); C556(0.93); C627(0.95); C313(1.00)  LDD1591  [33]
 LDCM0388  CL118 HEK-293T C477(0.95); C556(0.91); C627(0.92); C313(1.01)  LDD1592  [33]
 LDCM0389  CL119 HEK-293T C477(1.00); C556(0.91); C627(0.97); C313(1.01)  LDD1593  [33]
 LDCM0390  CL12 HEK-293T C477(0.90); C556(0.90); C627(0.95); C313(1.08)  LDD1594  [33]
 LDCM0391  CL120 HEK-293T C477(0.84); C556(0.92); C627(0.92); C313(0.89)  LDD1595  [33]
 LDCM0392  CL121 HEK-293T C477(1.06); C556(0.95); C627(0.90); C313(0.98)  LDD1596  [33]
 LDCM0393  CL122 HEK-293T C477(0.82); C556(0.96); C627(0.93); C313(0.98)  LDD1597  [33]
 LDCM0394  CL123 HEK-293T C477(0.95); C556(0.88); C627(0.77); C313(0.97)  LDD1598  [33]
 LDCM0395  CL124 HEK-293T C477(0.79); C556(0.96); C627(0.96); C313(0.84)  LDD1599  [33]
 LDCM0396  CL125 HEK-293T C477(0.95); C556(0.94); C627(0.89); C313(1.00)  LDD1600  [33]
 LDCM0397  CL126 HEK-293T C477(0.81); C556(0.89); C627(0.89); C313(0.89)  LDD1601  [33]
 LDCM0398  CL127 HEK-293T C477(0.98); C556(0.91); C627(0.92); C313(1.01)  LDD1602  [33]
 LDCM0399  CL128 HEK-293T C477(0.82); C556(0.91); C627(0.91); C313(0.88)  LDD1603  [33]
 LDCM0400  CL13 HEK-293T C477(0.93); C556(0.95); C627(0.94); C313(0.99)  LDD1604  [33]
 LDCM0401  CL14 HEK-293T C477(0.77); C556(1.03); C627(0.86); C313(0.82)  LDD1605  [33]
 LDCM0402  CL15 HEK-293T C477(1.17); C556(0.90); C627(0.89); C313(0.99)  LDD1606  [33]
 LDCM0403  CL16 HEK-293T C477(0.88); C556(1.04); C627(0.93); C313(1.08)  LDD1607  [33]
 LDCM0404  CL17 HEK-293T C477(1.26); C556(0.90); C627(0.96); C313(0.93)  LDD1608  [33]
 LDCM0405  CL18 HEK-293T C477(0.95); C556(1.01); C627(0.88); C313(0.93)  LDD1609  [33]
 LDCM0406  CL19 HEK-293T C477(0.93); C556(0.85); C627(0.93); C313(1.12)  LDD1610  [33]
 LDCM0407  CL2 HEK-293T C477(0.91); C556(1.02); C627(1.04); C313(0.82)  LDD1611  [33]
 LDCM0408  CL20 HEK-293T C477(1.23); C556(0.83); C627(0.97); C313(0.83)  LDD1612  [33]
 LDCM0409  CL21 HEK-293T C477(1.00); C556(0.75); C627(1.01); C313(0.98)  LDD1613  [33]
 LDCM0410  CL22 HEK-293T C477(0.88); C556(0.78); C627(0.89); C313(0.97)  LDD1614  [33]
 LDCM0411  CL23 HEK-293T C477(1.04); C556(1.00); C627(1.08); C313(1.00)  LDD1615  [33]
 LDCM0412  CL24 HEK-293T C477(0.95); C556(0.95); C627(0.93); C313(1.16)  LDD1616  [33]
 LDCM0413  CL25 HEK-293T C477(0.94); C556(0.89); C627(0.94); C313(0.94)  LDD1617  [33]
 LDCM0414  CL26 HEK-293T C477(0.91); C556(1.00); C627(0.90); C313(0.93)  LDD1618  [33]
 LDCM0415  CL27 HEK-293T C477(1.18); C556(1.00); C627(1.00); C313(1.00)  LDD1619  [33]
 LDCM0416  CL28 HEK-293T C477(0.90); C556(0.99); C627(0.91); C313(1.00)  LDD1620  [33]
 LDCM0417  CL29 HEK-293T C477(0.96); C556(1.01); C627(0.90); C313(1.06)  LDD1621  [33]
 LDCM0418  CL3 HEK-293T C477(1.13); C556(0.95); C627(0.91); C313(1.11)  LDD1622  [33]
 LDCM0419  CL30 HEK-293T C477(0.89); C556(1.00); C627(1.04); C313(0.95)  LDD1623  [33]
 LDCM0420  CL31 HEK-293T C477(1.01); C556(0.89); C627(0.97); C313(1.05)  LDD1624  [33]
 LDCM0421  CL32 HEK-293T C477(0.93); C556(0.92); C627(1.03); C313(0.97)  LDD1625  [33]
 LDCM0422  CL33 HEK-293T C477(1.06); C556(0.76); C627(1.05); C313(0.96)  LDD1626  [33]
 LDCM0423  CL34 HEK-293T C477(1.01); C556(0.79); C627(0.92); C313(1.09)  LDD1627  [33]
 LDCM0424  CL35 HEK-293T C477(1.14); C556(1.00); C627(1.00); C313(0.92)  LDD1628  [33]
 LDCM0425  CL36 HEK-293T C477(0.86); C556(0.93); C627(0.98); C313(1.18)  LDD1629  [33]
 LDCM0426  CL37 HEK-293T C477(1.12); C556(0.98); C627(0.92); C313(1.01)  LDD1630  [33]
 LDCM0428  CL39 HEK-293T C477(1.17); C556(0.98); C627(0.84); C313(0.99)  LDD1632  [33]
 LDCM0429  CL4 HEK-293T C477(0.86); C556(0.95); C627(1.09); C313(1.13)  LDD1633  [33]
 LDCM0430  CL40 HEK-293T C477(0.95); C556(0.99); C627(0.92); C313(1.01)  LDD1634  [33]
 LDCM0431  CL41 HEK-293T C477(1.11); C556(0.95); C627(0.93); C313(1.07)  LDD1635  [33]
 LDCM0432  CL42 HEK-293T C477(0.96); C556(0.96); C627(0.92); C313(0.99)  LDD1636  [33]
 LDCM0433  CL43 HEK-293T C477(1.12); C556(0.91); C627(1.00); C313(0.79)  LDD1637  [33]
 LDCM0434  CL44 HEK-293T C477(0.97); C556(0.91); C627(0.92); C313(1.12)  LDD1638  [33]
 LDCM0435  CL45 HEK-293T C477(1.18); C556(0.77); C627(0.92); C313(0.94)  LDD1639  [33]
 LDCM0436  CL46 HEK-293T C477(1.13); C556(0.82); C627(0.98); C313(1.12)  LDD1640  [33]
 LDCM0437  CL47 HEK-293T C477(1.13); C556(1.03); C627(1.04); C313(0.94)  LDD1641  [33]
 LDCM0438  CL48 HEK-293T C477(0.91); C556(1.00); C627(0.99); C313(1.13)  LDD1642  [33]
 LDCM0439  CL49 HEK-293T C477(1.04); C556(0.90); C627(0.88); C313(1.09)  LDD1643  [33]
 LDCM0440  CL5 HEK-293T C477(1.13); C556(1.04); C627(0.97); C313(1.06)  LDD1644  [33]
 LDCM0441  CL50 HEK-293T C477(0.85); C556(0.90); C627(0.88); C313(0.93)  LDD1645  [33]
 LDCM0443  CL52 HEK-293T C477(0.89); C556(0.94); C627(0.94); C313(1.01)  LDD1646  [33]
 LDCM0444  CL53 HEK-293T C477(1.10); C556(0.88); C627(0.95); C313(0.99)  LDD1647  [33]
 LDCM0445  CL54 HEK-293T C477(0.82); C556(0.83); C627(0.73); C313(0.97)  LDD1648  [33]
 LDCM0446  CL55 HEK-293T C477(1.03); C556(0.82); C627(0.91); C313(0.84)  LDD1649  [33]
 LDCM0447  CL56 HEK-293T C477(0.98); C556(0.79); C627(1.00); C313(1.15)  LDD1650  [33]
 LDCM0448  CL57 HEK-293T C477(0.91); C556(0.73); C627(1.02); C313(0.92)  LDD1651  [33]
 LDCM0449  CL58 HEK-293T C477(1.17); C556(0.78); C627(1.00); C313(1.08)  LDD1652  [33]
 LDCM0450  CL59 HEK-293T C477(0.95); C556(0.96); C627(1.01); C313(0.99)  LDD1653  [33]
 LDCM0451  CL6 HEK-293T C477(0.95); C556(0.89); C627(0.77); C313(1.09)  LDD1654  [33]
 LDCM0452  CL60 HEK-293T C477(0.91); C556(0.87); C627(1.00); C313(0.96)  LDD1655  [33]
 LDCM0453  CL61 HEK-293T C477(1.02); C556(0.92); C627(0.78); C313(0.94)  LDD1656  [33]
 LDCM0454  CL62 HEK-293T C477(0.88); C556(0.96); C627(0.91); C313(0.95)  LDD1657  [33]
 LDCM0455  CL63 HEK-293T C477(0.97); C556(0.96); C627(0.90); C313(1.11)  LDD1658  [33]
 LDCM0456  CL64 HEK-293T C477(0.93); C556(0.87); C627(0.82); C313(1.02)  LDD1659  [33]
 LDCM0457  CL65 HEK-293T C477(0.97); C556(0.95); C627(0.94); C313(0.98)  LDD1660  [33]
 LDCM0458  CL66 HEK-293T C477(0.81); C556(0.93); C627(0.80); C313(0.95)  LDD1661  [33]
 LDCM0459  CL67 HEK-293T C477(0.94); C556(0.90); C627(0.97); C313(1.00)  LDD1662  [33]
 LDCM0460  CL68 HEK-293T C477(1.11); C556(0.86); C627(0.94); C313(0.98)  LDD1663  [33]
 LDCM0461  CL69 HEK-293T C477(0.96); C556(0.84); C627(0.99); C313(0.99)  LDD1664  [33]
 LDCM0462  CL7 HEK-293T C477(1.04); C556(0.93); C627(0.90); C313(0.89)  LDD1665  [33]
 LDCM0463  CL70 HEK-293T C477(0.79); C556(0.84); C627(1.01); C313(1.17)  LDD1666  [33]
 LDCM0464  CL71 HEK-293T C477(1.00); C556(0.99); C627(1.08); C313(1.01)  LDD1667  [33]
 LDCM0465  CL72 HEK-293T C477(0.96); C556(0.94); C627(0.99); C313(1.02)  LDD1668  [33]
 LDCM0466  CL73 HEK-293T C477(0.94); C556(0.91); C627(0.95); C313(1.09)  LDD1669  [33]
 LDCM0467  CL74 HEK-293T C477(0.85); C556(0.95); C627(0.94); C313(0.87)  LDD1670  [33]
 LDCM0469  CL76 HEK-293T C477(0.89); C556(1.02); C627(1.05); C313(1.06)  LDD1672  [33]
 LDCM0470  CL77 HEK-293T C477(1.06); C556(0.88); C627(0.95); C313(1.01)  LDD1673  [33]
 LDCM0471  CL78 HEK-293T C477(1.19); C556(0.98); C627(0.93); C313(1.08)  LDD1674  [33]
 LDCM0472  CL79 HEK-293T C477(0.83); C556(0.91); C627(0.97); C313(0.97)  LDD1675  [33]
 LDCM0473  CL8 HEK-293T C477(1.13); C556(0.74); C627(1.15); C313(0.81)  LDD1676  [33]
 LDCM0474  CL80 HEK-293T C477(0.91); C556(0.93); C627(1.02); C313(1.08)  LDD1677  [33]
 LDCM0475  CL81 HEK-293T C477(0.97); C556(0.92); C627(0.99); C313(1.05)  LDD1678  [33]
 LDCM0476  CL82 HEK-293T C477(0.83); C556(0.92); C627(0.95); C313(1.13)  LDD1679  [33]
 LDCM0477  CL83 HEK-293T C477(1.09); C556(1.01); C627(1.11); C313(1.06)  LDD1680  [33]
 LDCM0478  CL84 HEK-293T C477(0.88); C556(0.93); C627(0.93); C313(1.06)  LDD1681  [33]
 LDCM0479  CL85 HEK-293T C477(0.99); C556(0.92); C627(0.78); C313(1.07)  LDD1682  [33]
 LDCM0480  CL86 HEK-293T C477(0.94); C556(0.94); C627(0.95); C313(0.86)  LDD1683  [33]
 LDCM0481  CL87 HEK-293T C477(0.93); C556(0.97); C627(0.86); C313(0.97)  LDD1684  [33]
 LDCM0482  CL88 HEK-293T C477(0.93); C556(1.02); C627(0.93); C313(0.99)  LDD1685  [33]
 LDCM0483  CL89 HEK-293T C477(1.02); C556(1.06); C627(0.87); C313(1.00)  LDD1686  [33]
 LDCM0484  CL9 HEK-293T C477(1.16); C556(0.81); C627(1.10); C313(1.04)  LDD1687  [33]
 LDCM0485  CL90 HEK-293T C477(0.74); C556(0.73); C627(1.02); C313(0.99)  LDD1688  [33]
 LDCM0486  CL91 HEK-293T C477(0.93); C556(0.97); C627(0.96); C313(0.88)  LDD1689  [33]
 LDCM0487  CL92 HEK-293T C477(0.93); C556(0.90); C627(0.94); C313(0.99)  LDD1690  [33]
 LDCM0488  CL93 HEK-293T C477(0.92); C556(0.92); C627(0.95); C313(1.04)  LDD1691  [33]
 LDCM0489  CL94 HEK-293T C477(0.87); C556(0.96); C627(1.01); C313(0.92)  LDD1692  [33]
 LDCM0490  CL95 HEK-293T C477(1.06); C556(0.87); C627(0.80); C313(0.87)  LDD1693  [33]
 LDCM0491  CL96 HEK-293T C477(0.94); C556(0.93); C627(0.91); C313(1.02)  LDD1694  [33]
 LDCM0492  CL97 HEK-293T C477(1.02); C556(0.90); C627(0.91); C313(1.00)  LDD1695  [33]
 LDCM0493  CL98 HEK-293T C477(0.87); C556(0.94); C627(1.00); C313(1.05)  LDD1696  [33]
 LDCM0494  CL99 HEK-293T C477(1.01); C556(0.95); C627(0.93); C313(1.11)  LDD1697  [33]
 LDCM0189  Compound 16 HEK-293T 38.10  LDD0492  [27]
 LDCM0182  Compound 18 HEK-293T 10.64  LDD0501  [27]
 LDCM0190  Compound 34 HEK-293T 13.22  LDD0497  [27]
 LDCM0192  Compound 35 HEK-293T 9.58  LDD0491  [27]
 LDCM0194  Compound 37 HEK-293T 14.68  LDD0498  [27]
 LDCM0195  Compound 38 HEK-293T 15.69  LDD0499  [27]
 LDCM0196  Compound 39 HEK-293T 5.73  LDD0496  [27]
 LDCM0197  Compound 40 HEK-293T 9.52  LDD0495  [27]
 LDCM0183  Compound 42 HEK-293T 5.10  LDD0500  [27]
 LDCM0495  E2913 HEK-293T C477(1.16); C556(0.90); C627(0.82); C313(1.02)  LDD1698  [33]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C556(1.06)  LDD1702  [6]
 LDCM0625  F8 Ramos C556(1.61); C869(0.75)  LDD2187  [34]
 LDCM0572  Fragment10 Ramos C556(1.06)  LDD2189  [34]
 LDCM0573  Fragment11 Ramos C556(1.16); C869(0.50)  LDD2190  [34]
 LDCM0574  Fragment12 Ramos C556(0.81)  LDD2191  [34]
 LDCM0575  Fragment13 Ramos C556(1.06)  LDD2192  [34]
 LDCM0576  Fragment14 Ramos C556(0.68); C869(0.91)  LDD2193  [34]
 LDCM0579  Fragment20 Ramos C556(0.65)  LDD2194  [34]
 LDCM0580  Fragment21 Ramos C556(1.12)  LDD2195  [34]
 LDCM0582  Fragment23 Ramos C556(1.21)  LDD2196  [34]
 LDCM0578  Fragment27 Ramos C556(1.28)  LDD2197  [34]
 LDCM0586  Fragment28 Ramos C556(1.10)  LDD2198  [34]
 LDCM0588  Fragment30 Ramos C556(1.34)  LDD2199  [34]
 LDCM0589  Fragment31 Ramos C556(0.97)  LDD2200  [34]
 LDCM0590  Fragment32 Ramos C556(1.01)  LDD2201  [34]
 LDCM0468  Fragment33 HEK-293T C477(1.16); C556(0.94); C627(0.92); C313(1.05)  LDD1671  [33]
 LDCM0596  Fragment38 Ramos C556(0.87)  LDD2203  [34]
 LDCM0566  Fragment4 Ramos C556(0.91); C869(0.64)  LDD2184  [34]
 LDCM0427  Fragment51 HEK-293T C477(1.04); C556(0.95); C627(0.89); C313(0.96)  LDD1631  [33]
 LDCM0610  Fragment52 Ramos C556(1.46)  LDD2204  [34]
 LDCM0614  Fragment56 Ramos C556(1.44)  LDD2205  [34]
 LDCM0617  Fragment63-S Jurkat _(20.00)  LDD1490  [7]
 LDCM0569  Fragment7 Ramos C556(0.98)  LDD2186  [34]
 LDCM0571  Fragment9 Ramos C556(1.04)  LDD2188  [34]
 LDCM0116  HHS-0101 DM93 Y921(0.37); Y979(0.45); Y614(1.07)  LDD0264  [11]
 LDCM0117  HHS-0201 DM93 Y921(0.90); Y614(2.47)  LDD0265  [11]
 LDCM0118  HHS-0301 DM93 Y921(0.43); Y614(4.47)  LDD0266  [11]
 LDCM0119  HHS-0401 DM93 Y921(0.21); Y979(0.88); Y614(4.68)  LDD0267  [11]
 LDCM0120  HHS-0701 DM93 Y921(0.47); Y614(1.54); Y979(2.18)  LDD0268  [11]
 LDCM0107  IAA HeLa C313(0.00); C627(0.00)  LDD0221  [23]
 LDCM0124  JWB142 DM93 Y921(0.29)  LDD0286  [10]
 LDCM0127  JWB152 DM93 Y921(1.12)  LDD0289  [10]
 LDCM0128  JWB198 DM93 Y921(0.43)  LDD0290  [10]
 LDCM0079  kambe_cp64 PC-3 5.29  LDD0135  [30]
 LDCM0022  KB02 HEK-293T C477(0.92); C780(0.90); C556(0.98); C627(0.94)  LDD1492  [33]
 LDCM0023  KB03 HEK-293T C477(0.92); C780(1.03); C556(1.12); C627(0.94)  LDD1497  [33]
 LDCM0024  KB05 COLO792 C627(1.48)  LDD3310  [5]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C556(1.47)  LDD2121  [6]
 LDCM0109  NEM HeLa C627(0.00); H1016(0.00)  LDD0223  [23]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C556(1.16)  LDD2093  [6]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C556(0.55)  LDD2096  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C477(1.35)  LDD2099  [6]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C477(0.99)  LDD2101  [6]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C556(1.70)  LDD2105  [6]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C556(0.49)  LDD2106  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C477(1.02)  LDD2107  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C556(0.63)  LDD2109  [6]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C556(1.13)  LDD2111  [6]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C556(0.71)  LDD2115  [6]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C556(0.96)  LDD2116  [6]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C556(2.47)  LDD2119  [6]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C556(0.92)  LDD2120  [6]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C556(0.99)  LDD2122  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C556(0.66); C477(0.97); C627(0.87)  LDD2123  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C556(1.04); C477(1.21)  LDD2125  [6]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C556(0.98)  LDD2126  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C556(1.34); C477(0.77)  LDD2127  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C556(0.85)  LDD2129  [6]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C477(0.52)  LDD2133  [6]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C556(0.72)  LDD2134  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C556(0.93); C477(1.87)  LDD2135  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C556(1.12)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C556(0.92); C477(1.09)  LDD2137  [6]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C556(1.46)  LDD1700  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C556(1.16); C477(0.95)  LDD2140  [6]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C477(0.73); C627(0.61)  LDD2141  [6]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C556(0.97)  LDD2143  [6]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C556(3.25)  LDD2144  [6]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C627(0.17)  LDD2145  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C556(0.93)  LDD2146  [6]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C477(0.39)  LDD2148  [6]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C556(0.97)  LDD2149  [6]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C556(0.98)  LDD2150  [6]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C556(1.00)  LDD2151  [6]
 LDCM0081  Rofecoxib A-549 2.06  LDD0141  [29]
 LDCM0154  YY4 T cell 3.59  LDD0400  [8]

References

1 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
8 A Chemical Proteomic Probe for the Mitochondrial Pyruvate Carrier Complex. Angew Chem Int Ed Engl. 2020 Mar 2;59(10):3896-3899. doi: 10.1002/anie.201914391. Epub 2020 Feb 11.
9 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
10 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
11 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
12 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
13 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
14 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
15 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
16 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
17 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
18 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
19 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
20 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
21 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
22 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
23 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
24 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
25 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
26 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
27 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
28 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
29 A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. doi: 10.1016/j.cell.2015.05.045.
30 Mapping the protein interaction landscape for fully functionalized small-molecule probes in human cells. J Am Chem Soc. 2014 Jul 30;136(30):10777-82. doi: 10.1021/ja505517t. Epub 2014 Jul 21.
31 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652
32 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
33 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
34 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578