Probe Name	YY4-yne					Probe Info
Probe concentration	10 uM
Criteria	Quantification: Probe vs (Probe+Competitor)
Quantitative Method	LFQ
Competitor Name	YY4					Competitor Info
Competitor Concentration	10 uM
In Vivo Experiment Model	Model Type			Living cell
	Derived Tissue			Peripheral blood
	Disease Model		Normal
	Model Name		Human normal cells (T cell)

Target ID	Target Name					Binding Ratio
LDTP14535	6-phosphogluconolactonase (PGLS)					11.1
LDTP01707	Thioredoxin domain-containing protein 12 (TXNDC12)					10.5
LDTP04988	Thioredoxin reductase-like selenoprotein T (SELENOT)					8.1
LDTP12040	Prostaglandin E synthase 2 (PTGES2)					7.7
LDTP03831	Phospholipid hydroperoxide glutathione peroxidase GPX4 (GPX4)					7.4
LDTP12539	DNA dC->dU-editing enzyme APOBEC-3C (APOBEC3C)					7.4
LDTP09344	Prostamide/prostaglandin F synthase (PRXL2B)					6.0
LDTP14264	Choline/ethanolaminephosphotransferase 1 (CEPT1)					5.9
LDTP03540	Heme oxygenase 2 (HMOX2)					5.4
LDTP05128	Glutathione S-transferase omega-1 (GSTO1)					5.2
LDTP05408	Antigen peptide transporter 1 (TAP1)					3.9
LDTP01704	Phosphatidylserine lipase ABHD16A (ABHD16A)					3.9
LDTP07591	Neutral cholesterol ester hydrolase 1 (NCEH1)					3.7
LDTP02852	Methylated-DNA--protein-cysteine methyltransferase (MGMT)					3.7
LDTP07003	Presequence protease, mitochondrial (PITRM1)					3.6
LDTP11178	Chitobiosyldiphosphodolichol beta-mannosyltransferase (ALG1)					3.6
LDTP03163	Sterol carrier protein 2 (SCP2)					3.6
LDTP05943	Myotubularin-related protein 1 (MTMR1)					3.6
LDTP02788	15-hydroxyprostaglandin dehydrogenase [NAD(+)] (HPGD)					3.5
LDTP17247	5'-nucleotidase domain-containing protein 1 (NT5DC1)					3.4
LDTP11107	Serine/threonine-protein phosphatase CPPED1 (CPPED1)					3.4
LDTP12297	Thioredoxin reductase 2, mitochondrial (TXNRD2)					3.4
LDTP06658	Thioredoxin reductase 1, cytoplasmic (TXNRD1)					3.3
LDTP01986	NADH-ubiquinone oxidoreductase chain 5 (MT-ND5)					3.3
LDTP02684	Delta-aminolevulinic acid dehydratase (ALAD)					3.2
LDTP16095	Ethylmalonyl-CoA decarboxylase (ECHDC1)					3.2
LDTP12064	Polyprenol reductase (SRD5A3)					3.0
LDTP11440	Lysine-specific demethylase 5D (KDM5D)					2.9
LDTP02860	Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2)					2.9
LDTP00697	Cytochrome b5 type B (CYB5B)					2.9
LDTP11601	(E3-independent) E2 ubiquitin-conjugating enzyme (UBE2O)					2.8
LDTP08181	Glutaredoxin-related protein 5, mitochondrial (GLRX5)					2.8
LDTP00415	Acyl-coenzyme A thioesterase 8 (ACOT8)					2.8
LDTP06787	Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1)					2.7
LDTP01394	DNA fragmentation factor subunit beta (DFFB)					2.6
LDTP14213	Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase (ALG6)					2.5
LDTP03437	DNA polymerase delta catalytic subunit (POLD1)					2.4
LDTP11294	Protein adenylyltransferase SelO, mitochondrial (SELENOO)					2.2
LDTP01462	Endonuclease domain-containing 1 protein (ENDOD1)					2.2
LDTP08232	Glycerol-3-phosphate acyltransferase 4 (GPAT4)					2.1
LDTP15370	Pseudouridylate synthase RPUSD2 (RPUSD2)					2.1
LDTP04074	Ubiquitin carboxyl-terminal hydrolase 5 (USP5)					2.0
LDTP03794	Hydroxymethylglutaryl-CoA lyase, mitochondrial (HMGCL)					2.0

Target ID	Target Name					Binding Ratio
LDTP01631	Mitochondrial pyruvate carrier 2 (MPC2)					11.6
LDTP11103	Thioredoxin domain-containing protein 17 (TXNDC17)					3.2
LDTP12210	Mitochondrial thiamine pyrophosphate carrier (SLC25A19)					3.2
LDTP04071	Voltage-dependent anion-selective channel protein 2 (VDAC2)					2.7
LDTP08344	Stimulator of interferon genes protein (STING1)					2.5
LDTP05511	Cytoskeleton-associated protein 4 (CKAP4)					2.4
LDTP04007	Huntingtin (HTT)					2.4
LDTP18459	StAR-related lipid transfer protein 7, mitochondrial (STARD7)					2.2
LDTP09987	Secretory carrier-associated membrane protein 4 (SCAMP4)					2.1
LDTP00546	Secretory carrier-associated membrane protein 1 (SCAMP1)					2.0

Target ID	Target Name					Binding Ratio
LDTP10995	AT-rich interactive domain-containing protein 3A (ARID3A)					4.6
LDTP08683	Tissue-resident T-cell transcription regulator protein ZNF683 (ZNF683)					2.3

Target ID	Target Name					Binding Ratio
LDTP14430	G-protein coupled receptor 171 (GPR171)					3.5

Target ID	Target Name					Binding Ratio
LDTP02491	HLA class I histocompatibility antigen, C alpha chain (HLA-C)					4.9
LDTP01913	HLA class I histocompatibility antigen, B alpha chain (HLA-B)					4.7
LDTP02040	HLA class I histocompatibility antigen, A alpha chain (HLA-A)					2.1

Target ID	Target Name					Binding Ratio
LDTP11075	Selenoprotein S (SELENOS)					5.5
LDTP18768	Pleckstrin homology domain-containing family D member 1 (PLEKHD1)					5.0
LDTP18400	DENN domain-containing protein 2D (DENND2D)					4.7
LDTP15599	UPF0729 protein C18orf32 (C18orf32)					4.4
LDTP01914	Putative HLA class I histocompatibility antigen, alpha chain H (HLA-H)					4.0
LDTP01970	Serotransferrin (TF)					3.6
LDTP14236	Selenoprotein K (SELENOK)					3.5
LDTP07508	Polyamine-modulated factor 1 (PMF1)					3.4
LDTP05734	Protein flightless-1 homolog (FLII)					3.4
LDTP01012	Selenoprotein F (SELENOF)					3.3
LDTP13402	Dynactin subunit 4 (DCTN4)					3.1
LDTP12412	Reticulon-4 (RTN4)					2.9
LDTP04812	Anthrax toxin receptor 2 (ANTXR2)					2.9
LDTP12022	Dedicator of cytokinesis protein 5 (DOCK5)					2.8
LDTP01536	Apolipoprotein L3 (APOL3)					2.8
LDTP08475	Carabin (TBC1D10C)					2.7
LDTP13579	Cip1-interacting zinc finger protein (CIZ1)					2.7
LDTP13913	Inner nuclear membrane protein Man1 (LEMD3)					2.7
LDTP10357	RUS family member 1 (RUSF1)					2.7
LDTP07912	Integrator complex subunit 8 (INTS8)					2.5
LDTP11140	Peroxiredoxin-like 2A (PRXL2A)					2.5
LDTP19672	Selenoprotein H (SELENOH)					2.2
LDTP13019	Vacuolar protein sorting-associated protein 18 homolog (VPS18)					2.2
LDTP15896	Ashwin (C2orf49)					2.1
LDTP06853	TBC1 domain family member 10B (TBC1D10B)					2.1
LDTP11379	TBC1 domain family member 10A (TBC1D10A)					2.0
LDTP07318	HAUS augmin-like complex subunit 3 (HAUS3)					2.0

1	A Chemical Proteomic Probe for the Mitochondrial Pyruvate Carrier Complex. Angew Chem Int Ed Engl. 2020 Mar 2;59(10):3896-3899. doi: 10.1002/anie.201914391. Epub 2020 Feb 11.