Details of the Target

General Information of Target

Target ID LDTP09344
Target Name Prostamide/prostaglandin F synthase (PRXL2B)
Gene Name PRXL2B
Gene ID 127281
Synonyms
C1orf93; FAM213B; Prostamide/prostaglandin F synthase; Prostamide/PG F synthase; Prostamide/PGF synthase; EC 1.11.1.20; Peroxiredoxin-like 2B; Protein FAM213B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSTVDLARVGACILKHAVTGEAVELRSLWREHACVVAGLRRFGCVVCRWIAQDLSSLAGL
LDQHGVRLVGVGPEALGLQEFLDGDYFAGELYLDESKQLYKELGFKRYNSLSILPAALGK
PVRDVAAKAKAVGIQGNLSGDLLQSGGLLVVSKGGDKVLLHFVQKSPGDYVPKEHILQVL
GISAEVCASDPPQCDREV
Target Bioclass
Enzyme
Family
Peroxiredoxin-like PRXL2 family, Prostamide/prostaglandin F synthase subfamily
Subcellular location
Cytoplasm, cytosol
Function Catalyzes the reduction of prostaglandin-ethanolamide H(2) (prostamide H(2)) to prostamide F(2alpha) with NADPH as proton donor. Also able to reduce prostaglandin H(2) to prostaglandin F(2alpha).
Uniprot ID
Q8TBF2
Ensemble ID
ENST00000378424.9
HGNC ID
HGNC:28390

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.G146R .
HUCCT1 SNV: p.G136V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K106(5.88); K128(10.00)  LDD0277  [1]
BTD
 Probe Info  		C12(0.93)  LDD2099  [2]
Johansson_61
 Probe Info  		_(9.59)  LDD1485  [3]
YY4-yne
 Probe Info  		6.02  LDD0400  [4]
DBIA
 Probe Info  		C44(53.87)  LDD0209  [5]
IPM
 Probe Info  		C47(1.13)  LDD1701  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [6]
NAIA_5
 Probe Info  		N.A.  LDD2223  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C12(1.02)  LDD2117  [2]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C12(1.43)  LDD2152  [2]
 LDCM0214  AC1 HEK-293T C34(0.96); C12(0.96); C44(1.05)  LDD1507  [8]
 LDCM0215  AC10 HEK-293T C34(1.08); C12(1.01)  LDD1508  [8]
 LDCM0226  AC11 HEK-293T C34(1.05); C12(1.05)  LDD1509  [8]
 LDCM0237  AC12 HEK-293T C34(0.99); C12(0.95)  LDD1510  [8]
 LDCM0259  AC14 HEK-293T C34(0.95); C12(1.14)  LDD1512  [8]
 LDCM0270  AC15 HEK-293T C34(1.03); C12(1.04); C44(1.16)  LDD1513  [8]
 LDCM0276  AC17 HEK-293T C34(0.92); C12(1.03); C44(1.22)  LDD1515  [8]
 LDCM0277  AC18 HEK-293T C34(0.99); C12(1.08)  LDD1516  [8]
 LDCM0278  AC19 HEK-293T C34(0.94); C12(1.03)  LDD1517  [8]
 LDCM0279  AC2 HEK-293T C34(1.02); C12(1.00)  LDD1518  [8]
 LDCM0280  AC20 HEK-293T C34(1.00); C12(0.96)  LDD1519  [8]
 LDCM0281  AC21 HEK-293T C44(1.34)  LDD1520  [8]
 LDCM0282  AC22 HEK-293T C34(1.01); C12(1.06)  LDD1521  [8]
 LDCM0283  AC23 HEK-293T C34(1.02); C12(1.06); C44(0.93)  LDD1522  [8]
 LDCM0284  AC24 HEK-293T C34(0.92); C12(1.05); C44(1.13)  LDD1523  [8]
 LDCM0285  AC25 HEK-293T C34(0.98); C12(0.93); C44(1.23)  LDD1524  [8]
 LDCM0286  AC26 HEK-293T C34(1.05); C12(1.05)  LDD1525  [8]
 LDCM0287  AC27 HEK-293T C34(1.03); C12(1.02)  LDD1526  [8]
 LDCM0288  AC28 HEK-293T C34(1.02); C12(0.98)  LDD1527  [8]
 LDCM0289  AC29 HEK-293T C44(1.33)  LDD1528  [8]
 LDCM0290  AC3 HEK-293T C34(1.01); C12(0.99)  LDD1529  [8]
 LDCM0291  AC30 HEK-293T C34(1.05); C12(1.07)  LDD1530  [8]
 LDCM0292  AC31 HEK-293T C34(1.09); C12(1.04); C44(0.98)  LDD1531  [8]
 LDCM0293  AC32 HEK-293T C34(0.93); C12(1.02); C44(1.03)  LDD1532  [8]
 LDCM0294  AC33 HEK-293T C34(0.94); C12(1.03); C44(1.00)  LDD1533  [8]
 LDCM0295  AC34 HEK-293T C34(1.05); C12(1.13)  LDD1534  [8]
 LDCM0296  AC35 HEK-293T C34(0.98); C12(1.02)  LDD1535  [8]
 LDCM0297  AC36 HEK-293T C34(0.99); C12(1.01)  LDD1536  [8]
 LDCM0298  AC37 HEK-293T C44(1.24)  LDD1537  [8]
 LDCM0299  AC38 HEK-293T C34(1.03); C12(1.23)  LDD1538  [8]
 LDCM0300  AC39 HEK-293T C34(1.02); C12(1.22); C44(1.19)  LDD1539  [8]
 LDCM0301  AC4 HEK-293T C34(0.96); C12(0.99)  LDD1540  [8]
 LDCM0302  AC40 HEK-293T C34(0.94); C12(1.05); C44(1.31)  LDD1541  [8]
 LDCM0303  AC41 HEK-293T C34(0.91); C12(0.97); C44(1.16)  LDD1542  [8]
 LDCM0304  AC42 HEK-293T C34(1.14); C12(1.10)  LDD1543  [8]
 LDCM0305  AC43 HEK-293T C34(1.10); C12(1.00)  LDD1544  [8]
 LDCM0306  AC44 HEK-293T C34(0.97); C12(1.11)  LDD1545  [8]
 LDCM0307  AC45 HEK-293T C44(1.19)  LDD1546  [8]
 LDCM0308  AC46 HEK-293T C34(1.03); C12(1.16)  LDD1547  [8]
 LDCM0309  AC47 HEK-293T C34(1.06); C12(1.21); C44(1.11)  LDD1548  [8]
 LDCM0310  AC48 HEK-293T C34(0.99); C12(1.09); C44(1.39)  LDD1549  [8]
 LDCM0311  AC49 HEK-293T C34(1.05); C12(0.95); C44(1.36)  LDD1550  [8]
 LDCM0312  AC5 HEK-293T C44(1.18)  LDD1551  [8]
 LDCM0313  AC50 HEK-293T C34(1.05); C12(1.07)  LDD1552  [8]
 LDCM0314  AC51 HEK-293T C34(0.98); C12(1.03)  LDD1553  [8]
 LDCM0315  AC52 HEK-293T C34(0.96); C12(1.08)  LDD1554  [8]
 LDCM0316  AC53 HEK-293T C44(1.34)  LDD1555  [8]
 LDCM0317  AC54 HEK-293T C34(1.00); C12(1.32)  LDD1556  [8]
 LDCM0318  AC55 HEK-293T C34(0.97); C12(1.11); C44(1.16)  LDD1557  [8]
 LDCM0319  AC56 HEK-293T C34(1.02); C12(1.08); C44(1.27)  LDD1558  [8]
 LDCM0320  AC57 HEK-293T C34(0.99); C12(1.06); C44(1.26)  LDD1559  [8]
 LDCM0321  AC58 HEK-293T C34(1.09); C12(1.06)  LDD1560  [8]
 LDCM0322  AC59 HEK-293T C34(0.99); C12(1.03)  LDD1561  [8]
 LDCM0323  AC6 HEK-293T C34(1.02); C12(1.20)  LDD1562  [8]
 LDCM0324  AC60 HEK-293T C34(1.02); C12(1.07)  LDD1563  [8]
 LDCM0325  AC61 HEK-293T C44(1.35)  LDD1564  [8]
 LDCM0326  AC62 HEK-293T C34(1.09); C12(1.11)  LDD1565  [8]
 LDCM0327  AC63 HEK-293T C34(1.09); C12(1.06); C44(1.29)  LDD1566  [8]
 LDCM0328  AC64 HEK-293T C34(1.11); C12(1.12); C44(1.32)  LDD1567  [8]
 LDCM0334  AC7 HEK-293T C34(1.05); C12(1.08); C44(1.15)  LDD1568  [8]
 LDCM0345  AC8 HEK-293T C34(0.96); C12(1.02); C44(1.27)  LDD1569  [8]
 LDCM0248  AKOS034007472 HEK-293T C44(1.22)  LDD1511  [8]
 LDCM0356  AKOS034007680 HEK-293T C34(0.98); C12(0.94); C44(1.58)  LDD1570  [8]
 LDCM0275  AKOS034007705 HEK-293T C34(0.91); C12(0.96); C44(1.19)  LDD1514  [8]
 LDCM0200  BPK-25 T cell C44(6.19)  LDD0516  [9]
 LDCM0632  CL-Sc Hep-G2 C34(0.47)  LDD2227  [7]
 LDCM0367  CL1 HEK-293T C34(1.10)  LDD1571  [8]
 LDCM0368  CL10 HEK-293T C34(1.77); C12(1.72)  LDD1572  [8]
 LDCM0369  CL100 HEK-293T C34(0.90); C12(0.76); C44(1.37)  LDD1573  [8]
 LDCM0370  CL101 HEK-293T C34(0.94)  LDD1574  [8]
 LDCM0371  CL102 HEK-293T C34(0.90); C12(0.83)  LDD1575  [8]
 LDCM0372  CL103 HEK-293T C34(1.00); C12(1.00); C44(1.16)  LDD1576  [8]
 LDCM0373  CL104 HEK-293T C34(1.04); C12(0.98); C44(1.05)  LDD1577  [8]
 LDCM0374  CL105 HEK-293T C34(1.01)  LDD1578  [8]
 LDCM0375  CL106 HEK-293T C34(0.93); C12(0.85)  LDD1579  [8]
 LDCM0376  CL107 HEK-293T C34(1.04); C12(1.05); C44(0.97)  LDD1580  [8]
 LDCM0377  CL108 HEK-293T C34(1.04); C12(0.96); C44(0.79)  LDD1581  [8]
 LDCM0378  CL109 HEK-293T C34(0.95)  LDD1582  [8]
 LDCM0379  CL11 HEK-293T C34(1.36); C12(1.53); C44(1.19)  LDD1583  [8]
 LDCM0380  CL110 HEK-293T C34(0.89); C12(1.01)  LDD1584  [8]
 LDCM0381  CL111 HEK-293T C34(0.92); C12(0.98); C44(0.92)  LDD1585  [8]
 LDCM0382  CL112 HEK-293T C34(0.91); C12(0.85); C44(1.19)  LDD1586  [8]
 LDCM0383  CL113 HEK-293T C34(1.10)  LDD1587  [8]
 LDCM0384  CL114 HEK-293T C34(0.89); C12(0.81)  LDD1588  [8]
 LDCM0385  CL115 HEK-293T C34(0.96); C12(1.02); C44(1.07)  LDD1589  [8]
 LDCM0386  CL116 HEK-293T C34(1.01); C12(0.88); C44(1.03)  LDD1590  [8]
 LDCM0387  CL117 HEK-293T C34(1.14)  LDD1591  [8]
 LDCM0388  CL118 HEK-293T C34(1.08); C12(0.92)  LDD1592  [8]
 LDCM0389  CL119 HEK-293T C34(1.06); C12(1.14); C44(1.35)  LDD1593  [8]
 LDCM0390  CL12 HEK-293T C34(1.20); C12(1.13); C44(2.83)  LDD1594  [8]
 LDCM0391  CL120 HEK-293T C34(0.93); C12(0.82); C44(1.03)  LDD1595  [8]
 LDCM0392  CL121 HEK-293T C34(0.94)  LDD1596  [8]
 LDCM0393  CL122 HEK-293T C34(1.00); C12(0.94)  LDD1597  [8]
 LDCM0394  CL123 HEK-293T C34(1.24); C12(1.12); C44(1.19)  LDD1598  [8]
 LDCM0395  CL124 HEK-293T C34(0.91); C12(0.80); C44(1.32)  LDD1599  [8]
 LDCM0396  CL125 HEK-293T C34(1.03)  LDD1600  [8]
 LDCM0397  CL126 HEK-293T C34(1.02); C12(0.91)  LDD1601  [8]
 LDCM0398  CL127 HEK-293T C34(0.98); C12(1.04); C44(1.29)  LDD1602  [8]
 LDCM0399  CL128 HEK-293T C34(1.06); C12(0.84); C44(1.11)  LDD1603  [8]
 LDCM0400  CL13 HEK-293T C34(1.17)  LDD1604  [8]
 LDCM0401  CL14 HEK-293T C34(1.15); C12(1.09)  LDD1605  [8]
 LDCM0402  CL15 HEK-293T C34(1.14); C12(1.13); C44(1.15)  LDD1606  [8]
 LDCM0403  CL16 HEK-293T C34(1.03); C12(1.00); C44(1.58)  LDD1607  [8]
 LDCM0404  CL17 HEK-293T C34(0.96); C12(1.08); C44(1.68)  LDD1608  [8]
 LDCM0405  CL18 HEK-293T C34(1.11); C12(1.09)  LDD1609  [8]
 LDCM0406  CL19 HEK-293T C34(1.12); C12(1.01)  LDD1610  [8]
 LDCM0407  CL2 HEK-293T C34(1.04); C12(1.10)  LDD1611  [8]
 LDCM0408  CL20 HEK-293T C34(1.01); C12(1.03)  LDD1612  [8]
 LDCM0409  CL21 HEK-293T C44(2.42)  LDD1613  [8]
 LDCM0410  CL22 HEK-293T C34(1.30); C12(1.40)  LDD1614  [8]
 LDCM0411  CL23 HEK-293T C34(1.18); C12(1.49); C44(1.31)  LDD1615  [8]
 LDCM0412  CL24 HEK-293T C34(1.12); C12(0.95); C44(1.43)  LDD1616  [8]
 LDCM0413  CL25 HEK-293T C34(1.09)  LDD1617  [8]
 LDCM0414  CL26 HEK-293T C34(1.00); C12(0.97)  LDD1618  [8]
 LDCM0415  CL27 HEK-293T C34(1.00); C12(1.05); C44(1.15)  LDD1619  [8]
 LDCM0416  CL28 HEK-293T C34(1.04); C12(0.86); C44(0.91)  LDD1620  [8]
 LDCM0417  CL29 HEK-293T C34(1.00); C12(1.01); C44(0.94)  LDD1621  [8]
 LDCM0418  CL3 HEK-293T C34(1.01); C12(1.10); C44(1.09)  LDD1622  [8]
 LDCM0419  CL30 HEK-293T C34(1.25); C12(1.13)  LDD1623  [8]
 LDCM0420  CL31 HEK-293T C34(1.13); C12(1.04)  LDD1624  [8]
 LDCM0421  CL32 HEK-293T C34(1.05); C12(1.02)  LDD1625  [8]
 LDCM0422  CL33 HEK-293T C44(1.20)  LDD1626  [8]
 LDCM0423  CL34 HEK-293T C34(1.24); C12(1.26)  LDD1627  [8]
 LDCM0424  CL35 HEK-293T C34(1.18); C12(1.32); C44(1.18)  LDD1628  [8]
 LDCM0425  CL36 HEK-293T C34(1.20); C12(1.02); C44(1.25)  LDD1629  [8]
 LDCM0426  CL37 HEK-293T C34(1.02)  LDD1630  [8]
 LDCM0428  CL39 HEK-293T C34(1.06); C12(1.20); C44(0.99)  LDD1632  [8]
 LDCM0429  CL4 HEK-293T C34(1.13); C12(1.11); C44(1.26)  LDD1633  [8]
 LDCM0430  CL40 HEK-293T C34(1.04); C12(0.86); C44(0.80)  LDD1634  [8]
 LDCM0431  CL41 HEK-293T C34(0.91); C12(0.98); C44(1.03)  LDD1635  [8]
 LDCM0432  CL42 HEK-293T C34(1.12); C12(1.06)  LDD1636  [8]
 LDCM0433  CL43 HEK-293T C34(1.00); C12(1.04)  LDD1637  [8]
 LDCM0434  CL44 HEK-293T C34(1.00); C12(1.11)  LDD1638  [8]
 LDCM0435  CL45 HEK-293T C44(0.93)  LDD1639  [8]
 LDCM0436  CL46 HEK-293T C34(1.28); C12(1.25)  LDD1640  [8]
 LDCM0437  CL47 HEK-293T C34(1.19); C12(1.31); C44(1.06)  LDD1641  [8]
 LDCM0438  CL48 HEK-293T C34(1.31); C12(1.11); C44(1.54)  LDD1642  [8]
 LDCM0439  CL49 HEK-293T C34(1.01)  LDD1643  [8]
 LDCM0440  CL5 HEK-293T C34(0.99); C12(0.96); C44(1.03)  LDD1644  [8]
 LDCM0441  CL50 HEK-293T C34(0.91); C12(0.83)  LDD1645  [8]
 LDCM0443  CL52 HEK-293T C34(1.03); C12(0.88); C44(1.14)  LDD1646  [8]
 LDCM0444  CL53 HEK-293T C34(0.89); C12(1.10); C44(1.11)  LDD1647  [8]
 LDCM0445  CL54 HEK-293T C34(1.46); C12(1.52)  LDD1648  [8]
 LDCM0446  CL55 HEK-293T C34(1.09); C12(1.07)  LDD1649  [8]
 LDCM0447  CL56 HEK-293T C34(1.02); C12(1.13)  LDD1650  [8]
 LDCM0448  CL57 HEK-293T C44(0.86)  LDD1651  [8]
 LDCM0449  CL58 HEK-293T C34(1.36); C12(1.45)  LDD1652  [8]
 LDCM0450  CL59 HEK-293T C34(1.10); C12(1.50); C44(1.07)  LDD1653  [8]
 LDCM0451  CL6 HEK-293T C34(0.83); C12(0.81)  LDD1654  [8]
 LDCM0452  CL60 HEK-293T C34(1.21); C12(1.17); C44(1.31)  LDD1655  [8]
 LDCM0453  CL61 HEK-293T C34(1.08)  LDD1656  [8]
 LDCM0454  CL62 HEK-293T C34(1.10); C12(0.87)  LDD1657  [8]
 LDCM0455  CL63 HEK-293T C34(0.99); C12(1.04); C44(0.92)  LDD1658  [8]
 LDCM0456  CL64 HEK-293T C34(0.98); C12(0.87); C44(0.78)  LDD1659  [8]
 LDCM0457  CL65 HEK-293T C34(0.92); C12(1.03); C44(0.98)  LDD1660  [8]
 LDCM0458  CL66 HEK-293T C34(1.11); C12(1.12)  LDD1661  [8]
 LDCM0459  CL67 HEK-293T C34(1.09); C12(1.01)  LDD1662  [8]
 LDCM0460  CL68 HEK-293T C34(1.19); C12(1.12)  LDD1663  [8]
 LDCM0461  CL69 HEK-293T C44(1.23)  LDD1664  [8]
 LDCM0462  CL7 HEK-293T C34(1.13); C12(1.03)  LDD1665  [8]
 LDCM0463  CL70 HEK-293T C34(1.23); C12(1.45)  LDD1666  [8]
 LDCM0464  CL71 HEK-293T C34(1.13); C12(1.47); C44(1.17)  LDD1667  [8]
 LDCM0465  CL72 HEK-293T C34(1.04); C12(1.03); C44(1.56)  LDD1668  [8]
 LDCM0466  CL73 HEK-293T C34(1.03)  LDD1669  [8]
 LDCM0467  CL74 HEK-293T C34(1.06); C12(0.94)  LDD1670  [8]
 LDCM0469  CL76 HEK-293T C34(1.16); C12(0.85); C44(0.96)  LDD1672  [8]
 LDCM0470  CL77 HEK-293T C34(1.04); C12(1.05); C44(1.09)  LDD1673  [8]
 LDCM0471  CL78 HEK-293T C34(1.08); C12(1.11)  LDD1674  [8]
 LDCM0472  CL79 HEK-293T C34(1.13); C12(1.14)  LDD1675  [8]
 LDCM0473  CL8 HEK-293T C34(1.32); C12(1.32)  LDD1676  [8]
 LDCM0474  CL80 HEK-293T C34(1.10); C12(1.01)  LDD1677  [8]
 LDCM0475  CL81 HEK-293T C44(1.42)  LDD1678  [8]
 LDCM0476  CL82 HEK-293T C34(1.13); C12(1.42)  LDD1679  [8]
 LDCM0477  CL83 HEK-293T C34(1.16); C12(1.27); C44(1.21)  LDD1680  [8]
 LDCM0478  CL84 HEK-293T C34(1.12); C12(1.01); C44(1.73)  LDD1681  [8]
 LDCM0479  CL85 HEK-293T C34(1.04)  LDD1682  [8]
 LDCM0480  CL86 HEK-293T C34(1.05); C12(0.95)  LDD1683  [8]
 LDCM0481  CL87 HEK-293T C34(1.13); C12(0.97); C44(1.05)  LDD1684  [8]
 LDCM0482  CL88 HEK-293T C34(0.95); C12(0.86); C44(0.96)  LDD1685  [8]
 LDCM0483  CL89 HEK-293T C34(0.79); C12(0.95); C44(1.15)  LDD1686  [8]
 LDCM0484  CL9 HEK-293T C44(1.72)  LDD1687  [8]
 LDCM0485  CL90 HEK-293T C34(1.33); C12(1.20)  LDD1688  [8]
 LDCM0486  CL91 HEK-293T C34(1.14); C12(1.11)  LDD1689  [8]
 LDCM0487  CL92 HEK-293T C34(1.16); C12(1.12)  LDD1690  [8]
 LDCM0488  CL93 HEK-293T C44(1.03)  LDD1691  [8]
 LDCM0489  CL94 HEK-293T C34(1.14); C12(1.30)  LDD1692  [8]
 LDCM0490  CL95 HEK-293T C34(1.13); C12(1.28); C44(1.12)  LDD1693  [8]
 LDCM0491  CL96 HEK-293T C34(0.86); C12(0.84); C44(1.71)  LDD1694  [8]
 LDCM0492  CL97 HEK-293T C34(0.98)  LDD1695  [8]
 LDCM0493  CL98 HEK-293T C34(1.14); C12(0.99)  LDD1696  [8]
 LDCM0494  CL99 HEK-293T C34(1.03); C12(1.14); C44(0.88)  LDD1697  [8]
 LDCM0495  E2913 HEK-293T C34(1.19); C12(1.29); C44(1.00)  LDD1698  [8]
 LDCM0201  EV-3 T cell C44(6.49)  LDD0515  [9]
 LDCM0202  EV-93 T cell C44(7.11)  LDD0514  [9]
 LDCM0576  Fragment14 Ramos 0.95  LDD2193  [10]
 LDCM0586  Fragment28 Ramos 1.22  LDD2198  [10]
 LDCM0468  Fragment33 HEK-293T C34(1.24); C12(0.96); C44(1.20)  LDD1671  [8]
 LDCM0427  Fragment51 HEK-293T C34(1.02); C12(0.94)  LDD1631  [8]
 LDCM0616  Fragment61 Jurkat _(17.00)  LDD1489  [3]
 LDCM0615  Fragment63-R Jurkat _(11.26)  LDD1487  [3]
 LDCM0617  Fragment63-S Jurkat _(12.22)  LDD1490  [3]
 LDCM0569  Fragment7 Jurkat _(9.59)  LDD1485  [3]
 LDCM0022  KB02 HEK-293T C12(0.94)  LDD1492  [8]
 LDCM0023  KB03 Jurkat C44(53.87)  LDD0209  [5]
 LDCM0024  KB05 COLO792 C34(2.73)  LDD3310  [11]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C12(0.93)  LDD2099  [2]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C12(0.85)  LDD2107  [2]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C12(0.67)  LDD2109  [2]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C12(1.09)  LDD2111  [2]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C34(1.73)  LDD2119  [2]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C12(1.02)  LDD2123  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C12(0.71)  LDD2125  [2]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C12(1.10)  LDD2127  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C12(1.07)  LDD2136  [2]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C12(1.09); C44(0.96)  LDD2137  [2]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C12(0.72)  LDD2140  [2]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C12(1.83)  LDD2144  [2]
 LDCM0154  YY4 T cell 6.02  LDD0400  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
COP9 signalosome complex subunit 3 (COPS3) CSN3 family Q9UNS2
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
T-complex protein 11-like protein 1 (TCP11L1) TCP11 family Q9NUJ3

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
4 A Chemical Proteomic Probe for the Mitochondrial Pyruvate Carrier Complex. Angew Chem Int Ed Engl. 2020 Mar 2;59(10):3896-3899. doi: 10.1002/anie.201914391. Epub 2020 Feb 11.
5 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
10 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
11 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840