Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name Johansson_61  Probe Info 
Probe concentration 10 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
SILAC
Competitor Name Fragment7  Competitor Info 
Competitor Concentration 30 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Bone marrow
Disease Model T acute lymphoblastic leukemia [ICD-11:2A90]
Model Name Human T acute lymphoblastic leukemia cell lysate (Jurkat)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 84 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP01459  ABC-type organic anion transporter ABCA8 (ABCA8) 20.0
 LDTP03458  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38) 20.0
 LDTP12057  ATPase PAAT (PAAT) 20.0
 LDTP09904  Caspase-10 (CASP10) 20.0
 LDTP14264  Choline/ethanolaminephosphotransferase 1 (CEPT1) 20.0
 LDTP00394  Chromodomain-helicase-DNA-binding protein 1 (CHD1) 20.0
 LDTP02622  Creatine kinase U-type, mitochondrial (CKMT1A; CKMT1B) 20.0
 LDTP05507  Cyclin-dependent kinase 18 (CDK18) 20.0
 LDTP15154  Dehydrogenase/reductase SDR family member 13 (DHRS13) 20.0
 LDTP05953  Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) 20.0
 LDTP01141  E3 ubiquitin-protein ligase BRE1B (RNF40) 20.0
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) 20.0
 LDTP09505  GPI ethanolamine phosphate transferase 3 (PIGO) 20.0
 LDTP14019  HBS1-like protein (HBS1L) 20.0
 LDTP14036  Helicase ARIP4 (RAD54L2) 20.0
 LDTP14291  Mitogen-activated protein kinase kinase kinase 4 (MAP3K4) 20.0
 LDTP08265  N-alpha-acetyltransferase 40 (NAA40) 20.0
 LDTP03831  Phospholipid hydroperoxide glutathione peroxidase GPX4 (GPX4) 20.0
 LDTP12064  Polyprenol reductase (SRD5A3) 20.0
 LDTP09023  Probable E3 ubiquitin-protein ligase MARCHF10 (MARCHF10) 20.0
 LDTP05850  Probable methyltransferase TARBP1 (TARBP1) 20.0
 LDTP09961  Probable ubiquitin carboxyl-terminal hydrolase FAF-X (USP9X) 20.0
 LDTP12040  Prostaglandin E synthase 2 (PTGES2) 20.0
 LDTP13492  Protein argonaute-2 (AGO2) 20.0
 LDTP05433  Protein kinase C theta type (PRKCQ) 20.0
 LDTP04988  Thioredoxin reductase-like selenoprotein T (SELENOT) 20.0
 LDTP09749  Titin (TTN) 20.0
 LDTP13200  tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase (FTSJ1) 20.0
 LDTP08183  Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase (PIP4P1) 20.0
 LDTP11294  Protein adenylyltransferase SelO, mitochondrial (SELENOO) 19.5
 LDTP11178  Chitobiosyldiphosphodolichol beta-mannosyltransferase (ALG1) 18.4
 LDTP06211  Caspase-8 (CASP8) 17.9
 LDTP12835  Large ribosomal subunit protein mL39 (MRPL39) 17.8
 LDTP08232  Glycerol-3-phosphate acyltransferase 4 (GPAT4) 16.2
 LDTP13219  GTPase IMAP family member 2 (GIMAP2) 15.9
 LDTP02852  Methylated-DNA--protein-cysteine methyltransferase (MGMT) 15.5
 LDTP11187  COP9 signalosome complex subunit 4 (COPS4) 15.2
 LDTP09841  Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase (ALG3) 15.1
 LDTP11107  Serine/threonine-protein phosphatase CPPED1 (CPPED1) 15.0
 LDTP01394  DNA fragmentation factor subunit beta (DFFB) 15.0
 LDTP03230  Tyrosine-protein kinase JAK1 (JAK1) 13.0
 LDTP07875  Ubiquitin carboxyl-terminal hydrolase 34 (USP34) 12.4
 LDTP07591  Neutral cholesterol ester hydrolase 1 (NCEH1) 11.9
 LDTP09490  DDB1- and CUL4-associated factor 11 (DCAF11) 11.9
 LDTP06721  GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase (ALG11) 11.8
 LDTP14213  Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase (ALG6) 11.7
 LDTP04358  Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A) 11.4
 LDTP00697  Cytochrome b5 type B (CYB5B) 11.0
 LDTP10828  2-aminoethanethiol dioxygenase (ADO) 10.8
 LDTP04328  Selenide, water dikinase 1 (SEPHS1) 10.6
 LDTP03725  Replication factor C subunit 4 (RFC4) 10.5
 LDTP12444  Xaa-Pro aminopeptidase 1 (XPNPEP1) 10.5
 LDTP03419  Proteasome subunit beta type-5 (PSMB5) 10.4
 LDTP10917  Selenide, water dikinase 2 (SEPHS2) 10.4
 LDTP02264  Asparagine synthetase [glutamine-hydrolyzing] (ASNS) 10.2
 LDTP03656  Cystathionine gamma-lyase (CTH) 10.2
 LDTP06658  Thioredoxin reductase 1, cytoplasmic (TXNRD1) 9.7
 LDTP09344  Prostamide/prostaglandin F synthase (PRXL2B) 9.6
 LDTP09598  Mitochondrial coenzyme A diphosphatase NUDT8 (NUDT8) 9.2
 LDTP02860  Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) 9.1
 LDTP03163  Sterol carrier protein 2 (SCP2) 9.1
 LDTP13904  Probable ATP-dependent RNA helicase DDX52 (DDX52) 8.9
 LDTP03540  Heme oxygenase 2 (HMOX2) 8.2
 LDTP06900  Protein mono-ADP-ribosyltransferase PARP10 (PARP10) 8.2
 LDTP04232  4-trimethylaminobutyraldehyde dehydrogenase (ALDH9A1) 7.6
 LDTP04333  GMP synthase [glutamine-hydrolyzing] (GMPS) 7.5
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) 7.4
 LDTP10386  ERO1-like protein alpha (ERO1A) 7.1
 LDTP13154  E3 ubiquitin-protein ligase RNF14 (RNF14) 7.1
 LDTP00252  Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PIK3CD) 6.7
 LDTP07218  E3 ubiquitin-protein ligase BRE1A (RNF20) 6.3
 LDTP10368  Methylthioribulose-1-phosphate dehydratase (APIP) 6.2
 LDTP15370  Pseudouridylate synthase RPUSD2 (RPUSD2) 5.9
 LDTP13302  Nuclear prelamin A recognition factor (NARF) 5.8
 LDTP09976  Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 (ATP2A3) 5.6
 LDTP00678  Lysine-specific demethylase 6A (KDM6A) 5.4
 LDTP19892  DGAT1/2-independent enzyme synthesizing storage lipids (TMEM68) 5.3
 LDTP12297  Thioredoxin reductase 2, mitochondrial (TXNRD2) 5.2
 LDTP17022  Secernin-3 (SCRN3) 4.7
 LDTP01462  Endonuclease domain-containing 1 protein (ENDOD1) 4.6
 LDTP04471  Ribosomal protein S6 kinase alpha-3 (RPS6KA3) 4.5
 LDTP10787  Tribbles homolog 3 (TRIB3) 4.4
 LDTP04135  Glutamine--tRNA ligase (QARS1) 4.2
 LDTP01704  Phosphatidylserine lipase ABHD16A (ABHD16A) 4.1
Transporter and channel
Click to Show/Hide to Show 14 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05511  Cytoskeleton-associated protein 4 (CKAP4) 20.0
 LDTP00970  Gasdermin-E (GSDME) 20.0
 LDTP06293  Metal cation symporter ZIP14 (SLC39A14) 20.0
 LDTP08029  Nucleoporin p54 (NUP54) 20.0
 LDTP10073  Protein RFT1 homolog (RFT1) 20.0
 LDTP01969  Transferrin receptor protein 1 (TFRC) 20.0
 LDTP09038  Mixed lineage kinase domain-like protein (MLKL) 14.7
 LDTP05875  Transmembrane emp24 domain-containing protein 1 (TMED1) 11.7
 LDTP15979  Transmembrane protein 245 (TMEM245) 11.6
 LDTP08344  Stimulator of interferon genes protein (STING1) 7.5
 LDTP01454  SUN domain-containing protein 1 (SUN1) 7.1
 LDTP05814  Battenin (CLN3) 6.4
 LDTP04800  Nuclear pore complex protein Nup107 (NUP107) 5.7
 LDTP04849  CD81 antigen (CD81) 4.6
Transcription factor
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03969  Signal transducer and activator of transcription 1-alpha/beta (STAT1) 4.0
Other
Click to Show/Hide to Show 48 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP01963  Albumin (ALB) 20.0
 LDTP19476  AMMECR1-like protein (AMMECR1L) 20.0
 LDTP08573  Ankyrin repeat and KH domain-containing protein 1 (ANKHD1) 20.0
 LDTP07419  Centromere protein P (CENPP) 20.0
 LDTP04181  Coatomer subunit delta (ARCN1) 20.0
 LDTP05714  GATOR1 complex protein NPRL3 (NPRL3) 20.0
 LDTP05825  Growth factor receptor-bound protein 10 (GRB10) 20.0
 LDTP14076  Nuclear protein AMMECR1 (AMMECR1) 20.0
 LDTP11930  Oxysterol-binding protein-related protein 3 (OSBPL3) 20.0
 LDTP16261  PALM2-AKAP2 fusion protein (PALM2AKAP2) 20.0
 LDTP11140  Peroxiredoxin-like 2A (PRXL2A) 20.0
 LDTP17044  R3H domain-containing protein 1 (R3HDM1) 20.0
 LDTP05578  Retinoblastoma-like protein 2 (RBL2) 20.0
 LDTP14236  Selenoprotein K (SELENOK) 20.0
 LDTP11075  Selenoprotein S (SELENOS) 20.0
 LDTP01105  SLIT-ROBO Rho GTPase-activating protein 2 (SRGAP2) 20.0
 LDTP09684  Splicing regulatory glutamine/lysine-rich protein 1 (SREK1) 20.0
 LDTP00236  Transcription elongation factor SPT5 (SUPT5H) 20.0
 LDTP15278  Tubulin epsilon and delta complex protein 1 (TEDC1) 20.0
 LDTP17802  Glutathione S-transferase C-terminal domain-containing protein (GSTCD) 18.5
 LDTP15599  UPF0729 protein C18orf32 (C18orf32) 17.3
 LDTP01522  Reticulon-3 (RTN3) 16.5
 LDTP03399  CD82 antigen (CD82) 14.1
 LDTP13019  Vacuolar protein sorting-associated protein 18 homolog (VPS18) 12.7
 LDTP19672  Selenoprotein H (SELENOH) 11.8
 LDTP00737  Centriolar coiled-coil protein of 110 kDa (CCP110) 11.3
 LDTP13786  TRAF3-interacting JNK-activating modulator (TRAF3IP3) 11.1
 LDTP11533  Oxysterol-binding protein-related protein 6 (OSBPL6) 11.1
 LDTP07986  RAS guanyl-releasing protein 2 (RASGRP2) 10.6
 LDTP13936  Protein MTO1 homolog, mitochondrial (MTO1) 10.6
 LDTP09783  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (GBF1) 10.4
 LDTP07888  Protein unc-13 homolog D (UNC13D) 10.4
 LDTP06479  Tubulin-specific chaperone E (TBCE) 10.3
 LDTP02031  Keratin, type II cytoskeletal 1 (KRT1) 10.1
 LDTP03792  Keratin, type II cytoskeletal 2 epidermal (KRT2) 10.0
 LDTP13338  Vacuolar protein sorting-associated protein 51 homolog (VPS51) 9.8
 LDTP19860  Coiled-coil domain-containing protein 97 (CCDC97) 8.9
 LDTP14095  Ankyrin repeat and SOCS box protein 3 (ASB3) 8.0
 LDTP01012  Selenoprotein F (SELENOF) 7.8
 LDTP18479  Asparagine synthetase domain-containing protein 1 (ASNSD1) 7.5
 LDTP01021  Perilipin-3 (PLIN3) 7.3
 LDTP12680  Fanconi anemia group I protein (FANCI) 7.3
 LDTP10357  RUS family member 1 (RUSF1) 5.4
 LDTP13979  Cytosolic iron-sulfur assembly component 2B (CIAO2B) 5.3
 LDTP06051  Kelch-like ECH-associated protein 1 (KEAP1) 5.1
 LDTP13431  Protein fem-1 homolog B (FEM1B) 4.7
 LDTP09549  Conserved oligomeric Golgi complex subunit 1 (COG1) 4.5
 LDTP13323  Multifunctional methyltransferase subunit TRM112-like protein (TRMT112) 4.3

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.