Details of the Target

General Information of Target

Target ID LDTP11930
Target Name Oxysterol-binding protein-related protein 3 (OSBPL3)
Gene Name OSBPL3
Gene ID 26031
Synonyms
KIAA0704; ORP3; OSBP3; Oxysterol-binding protein-related protein 3; ORP-3; OSBP-related protein 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKETIQGTGSWGPEPPGPGIPPAYSSPRRERLRWPPPPKPRLKSGGGFGPDPGSGTTVPA
RRLPVPRPSFDASASEEEEEEEEEEDEDEEEEVAAWRLPPRWSQLGTSQRPRPSRPTHRK
TCSQRRRRAMRAFRMLLYSKSTSLTFHWKLWGRHRGRRRGLAHPKNHLSPQQGGATPQVP
SPCCRFDSPRGPPPPRLGLLGALMAEDGVRGSPPVPSGPPMEEDGLRWTPKSPLDPDSGL
LSCTLPNGFGGQSGPEGERSLAPPDASILISNVCSIGDHVAQELFQGSDLGMAEEAERPG
EKAGQHSPLREEHVTCVQSILDEFLQTYGSLIPLSTDEVVEKLEDIFQQEFSTPSRKGLV
LQLIQSYQRMPGNAMVRGFRVAYKRHVLTMDDLGTLYGQNWLNDQVMNMYGDLVMDTVPE
KVHFFNSFFYDKLRTKGYDGVKRWTKNVDIFNKELLLIPIHLEVHWSLISVDVRRRTITY
FDSQRTLNRRCPKHIAKYLQAEAVKKDRLDFHQGWKGYFKMNVARQNNDSDCGAFVLQYC
KHLALSQPFSFTQQDMPKLRRQIYKELCHCKLTV
Target Bioclass
Other
Family
OSBP family
Subcellular location
Endoplasmic reticulum membrane
Function
Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes. Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With VAPA, may regulate ER morphology. Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion. Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3. Also binds 25-hydroxycholesterol and cholesterol.
Uniprot ID
Q9H4L5
Ensemble ID
ENST00000313367.7
HGNC ID
HGNC:16370

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CALU1 SNV: p.S215P DBIA    Probe Info 
HCT116 SNV: p.Y593H DBIA    Probe Info 
HEC1B SNV: p.V547M .
MDAMB157 SNV: p.S3N DBIA    Probe Info 
MDAMB453 SNV: p.E324K DBIA    Probe Info 
MKN45 SNV: p.G43R DBIA    Probe Info 
NCIH2286 SNV: p.D860Y .
NCIH2291 SNV: p.G287V DBIA    Probe Info 
NCIH23 SNV: p.D470Y DBIA    Probe Info 
NCIH661 SNV: p.A640S .
RL SNV: p.Y779N DBIA    Probe Info 
SF295 SNV: p.L432V DBIA    Probe Info 
SKMEL24 SNV: p.S636F DBIA    Probe Info 
TE4 SNV: p.E494Ter DBIA    Probe Info 
UACC257 Substitution: p.S729K .
ZR751 SNV: p.L835Q DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
CY-1
 Probe Info  		100.00  LDD0243  [1]
N1
 Probe Info  		100.00  LDD0242  [1]
STPyne
 Probe Info  		K129(7.69); K13(6.12); K27(3.03); K293(7.92)  LDD0277  [2]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [3]
BTD
 Probe Info  		C24(0.54)  LDD2089  [4]
Sulforaphane-probe2
 Probe Info  		1.05  LDD0160  [5]
Johansson_61
 Probe Info  		_(20.00)  LDD1485  [6]
DA-P3
 Probe Info  		4.31  LDD0182  [7]
AHL-Pu-1
 Probe Info  		C337(2.19)  LDD0168  [8]
EA-probe
 Probe Info  		N.A.  LDD0440  [9]
DBIA
 Probe Info  		C203(1.30); C24(1.11); C337(0.96)  LDD0078  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		C560(0.00); C689(0.00); C615(0.00)  LDD0038  [11]
IA-alkyne
 Probe Info  		C615(0.00); C560(0.00); C689(0.00); C114(0.00)  LDD0036  [11]
Lodoacetamide azide
 Probe Info  		C615(0.00); C229(0.00); C560(0.00); C689(0.00)  LDD0037  [11]
WYneO
 Probe Info  		N.A.  LDD0022  [12]
Compound 10
 Probe Info  		N.A.  LDD2216  [13]
IPM
 Probe Info  		C24(0.00); C203(0.00)  LDD0147  [14]
TFBX
 Probe Info  		C24(0.00); C337(0.00)  LDD0148  [14]
W1
 Probe Info  		N.A.  LDD0236  [15]
AOyne
 Probe Info  		15.00  LDD0443  [16]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C063
 Probe Info  		12.91  LDD1760  [17]
C361
 Probe Info  		17.63  LDD2022  [17]
C429
 Probe Info  		12.04  LDD2084  [17]
C431
 Probe Info  		13.64  LDD2086  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C337(2.19)  LDD0168  [8]
 LDCM0026  4SU-RNA+native RNA HEK-293T C337(3.38)  LDD0169  [8]
 LDCM0214  AC1 HCT 116 C520(0.82); C203(1.14); C24(1.20); C337(1.03)  LDD0531  [10]
 LDCM0215  AC10 HCT 116 C520(0.71); C203(0.98); C24(0.75); C337(1.21)  LDD0532  [10]
 LDCM0216  AC100 HCT 116 C520(0.72); C203(0.92); C24(1.28); C337(0.87)  LDD0533  [10]
 LDCM0217  AC101 HCT 116 C520(0.68); C203(1.01); C24(0.92); C337(0.88)  LDD0534  [10]
 LDCM0218  AC102 HCT 116 C520(0.79); C203(1.08); C24(1.03); C337(0.88)  LDD0535  [10]
 LDCM0219  AC103 HCT 116 C520(0.76); C203(1.43); C24(1.27); C337(0.99)  LDD0536  [10]
 LDCM0220  AC104 HCT 116 C520(0.69); C203(1.09); C24(1.02); C337(1.01)  LDD0537  [10]
 LDCM0221  AC105 HCT 116 C520(0.67); C203(1.43); C24(1.16); C337(0.95)  LDD0538  [10]
 LDCM0222  AC106 HCT 116 C520(0.50); C203(1.41); C24(1.11); C337(0.94)  LDD0539  [10]
 LDCM0223  AC107 HCT 116 C520(0.64); C203(1.08); C24(1.01); C337(1.12)  LDD0540  [10]
 LDCM0224  AC108 HCT 116 C520(0.69); C203(0.87); C24(0.97); C337(0.84)  LDD0541  [10]
 LDCM0225  AC109 HCT 116 C520(0.64); C203(0.94); C24(0.82); C337(0.83)  LDD0542  [10]
 LDCM0226  AC11 HCT 116 C520(0.79); C203(1.11); C24(0.68); C337(1.23)  LDD0543  [10]
 LDCM0227  AC110 HCT 116 C520(0.73); C203(1.11); C24(1.03); C337(0.84)  LDD0544  [10]
 LDCM0228  AC111 HCT 116 C520(0.80); C203(1.08); C24(1.13); C337(0.87)  LDD0545  [10]
 LDCM0229  AC112 HCT 116 C520(0.67); C203(1.27); C24(1.01); C337(1.03)  LDD0546  [10]
 LDCM0230  AC113 HCT 116 C203(1.31); C24(1.06); C337(1.01); C716(1.10)  LDD0547  [10]
 LDCM0231  AC114 HCT 116 C203(1.08); C24(1.14); C337(1.06); C716(0.83)  LDD0548  [10]
 LDCM0232  AC115 HCT 116 C203(1.38); C24(1.38); C337(1.15); C716(0.73)  LDD0549  [10]
 LDCM0233  AC116 HCT 116 C203(1.47); C24(1.18); C337(1.12); C716(0.74)  LDD0550  [10]
 LDCM0234  AC117 HCT 116 C203(1.16); C24(1.23); C337(1.02); C716(1.05)  LDD0551  [10]
 LDCM0235  AC118 HCT 116 C203(1.14); C24(0.95); C337(1.00); C716(1.01)  LDD0552  [10]
 LDCM0236  AC119 HCT 116 C203(1.09); C24(1.22); C337(1.07); C716(0.89)  LDD0553  [10]
 LDCM0237  AC12 HCT 116 C520(0.57); C203(0.79); C24(0.55); C337(1.08)  LDD0554  [10]
 LDCM0238  AC120 HCT 116 C203(1.56); C24(1.31); C337(1.11); C716(0.89)  LDD0555  [10]
 LDCM0239  AC121 HCT 116 C203(1.17); C24(1.12); C337(0.98); C716(1.11)  LDD0556  [10]
 LDCM0240  AC122 HCT 116 C203(1.08); C24(1.14); C337(1.08); C716(0.95)  LDD0557  [10]
 LDCM0241  AC123 HCT 116 C203(1.20); C24(0.92); C337(0.99); C716(1.13)  LDD0558  [10]
 LDCM0242  AC124 HCT 116 C203(0.92); C24(0.98); C337(0.98); C716(1.02)  LDD0559  [10]
 LDCM0243  AC125 HCT 116 C203(1.04); C24(1.03); C337(0.97); C716(0.99)  LDD0560  [10]
 LDCM0244  AC126 HCT 116 C203(1.22); C24(1.29); C337(1.05); C716(0.70)  LDD0561  [10]
 LDCM0245  AC127 HCT 116 C203(1.18); C24(1.08); C337(1.07); C716(0.77)  LDD0562  [10]
 LDCM0246  AC128 HCT 116 C203(1.08); C24(1.01); C337(1.23); C716(1.02)  LDD0563  [10]
 LDCM0247  AC129 HCT 116 C203(0.96); C24(0.96); C337(0.97); C716(1.22)  LDD0564  [10]
 LDCM0249  AC130 HCT 116 C203(1.17); C24(0.95); C337(1.07); C716(0.95)  LDD0566  [10]
 LDCM0250  AC131 HCT 116 C203(0.94); C24(0.71); C337(0.92); C716(1.30)  LDD0567  [10]
 LDCM0251  AC132 HCT 116 C203(1.13); C24(0.70); C337(0.95); C716(1.33)  LDD0568  [10]
 LDCM0252  AC133 HCT 116 C203(1.06); C24(0.71); C337(1.08); C716(0.95)  LDD0569  [10]
 LDCM0253  AC134 HCT 116 C203(1.28); C24(0.82); C337(1.16); C716(0.87)  LDD0570  [10]
 LDCM0254  AC135 HCT 116 C203(1.17); C24(1.06); C337(1.09); C716(0.87)  LDD0571  [10]
 LDCM0255  AC136 HCT 116 C203(1.21); C24(0.93); C337(1.08); C716(0.90)  LDD0572  [10]
 LDCM0256  AC137 HCT 116 C203(1.13); C24(0.65); C337(1.04); C716(1.03)  LDD0573  [10]
 LDCM0257  AC138 HCT 116 C203(1.38); C24(0.93); C337(1.21); C716(0.94)  LDD0574  [10]
 LDCM0258  AC139 HCT 116 C203(1.32); C24(0.76); C337(1.11); C716(0.86)  LDD0575  [10]
 LDCM0259  AC14 HCT 116 C520(0.58); C203(0.81); C24(0.55); C337(1.07)  LDD0576  [10]
 LDCM0260  AC140 HCT 116 C203(1.29); C24(1.01); C337(1.22); C716(0.90)  LDD0577  [10]
 LDCM0261  AC141 HCT 116 C203(1.26); C24(0.75); C337(1.13); C716(0.91)  LDD0578  [10]
 LDCM0262  AC142 HCT 116 C203(1.10); C24(1.01); C337(1.00); C716(1.44)  LDD0579  [10]
 LDCM0263  AC143 HCT 116 C716(0.90); C718(0.93); C24(0.99); C337(1.02)  LDD0580  [10]
 LDCM0264  AC144 HCT 116 C716(0.36); C718(0.40); C337(1.04); C24(1.33)  LDD0581  [10]
 LDCM0265  AC145 HCT 116 C716(0.83); C337(0.95); C203(1.07); C718(1.12)  LDD0582  [10]
 LDCM0266  AC146 HCT 116 C716(0.56); C718(0.69); C337(0.98); C24(1.15)  LDD0583  [10]
 LDCM0267  AC147 HCT 116 C716(0.40); C718(0.46); C337(1.01); C203(1.41)  LDD0584  [10]
 LDCM0268  AC148 HCT 116 C716(0.50); C718(0.58); C337(1.14); C24(1.79)  LDD0585  [10]
 LDCM0269  AC149 HCT 116 C716(0.38); C718(0.47); C337(1.13); C203(1.47)  LDD0586  [10]
 LDCM0270  AC15 HCT 116 C24(0.49); C515(0.82); C520(0.83); C716(1.04)  LDD0587  [10]
 LDCM0271  AC150 HCT 116 C716(0.92); C337(0.96); C718(0.97); C24(1.09)  LDD0588  [10]
 LDCM0272  AC151 HCT 116 C24(0.97); C716(0.98); C718(1.04); C337(1.07)  LDD0589  [10]
 LDCM0273  AC152 HCT 116 C716(0.38); C718(0.46); C337(1.08); C203(1.40)  LDD0590  [10]
 LDCM0274  AC153 HCT 116 C716(0.45); C718(0.56); C337(1.29); C203(1.99)  LDD0591  [10]
 LDCM0621  AC154 HCT 116 C203(1.30); C24(1.23); C337(0.98); C716(0.41)  LDD2158  [10]
 LDCM0622  AC155 HCT 116 C203(1.39); C24(1.39); C337(0.98); C716(0.40)  LDD2159  [10]
 LDCM0623  AC156 HCT 116 C203(1.16); C24(1.45); C337(0.97); C716(0.90)  LDD2160  [10]
 LDCM0624  AC157 HCT 116 C203(1.01); C24(0.90); C337(0.95); C716(0.84)  LDD2161  [10]
 LDCM0276  AC17 HCT 116 C337(1.00); C24(1.06); C203(1.10); C520(1.82)  LDD0593  [10]
 LDCM0277  AC18 HCT 116 C337(1.14); C24(1.15); C203(1.32); C520(1.93)  LDD0594  [10]
 LDCM0278  AC19 HCT 116 C24(0.78); C337(1.00); C203(1.13); C520(1.73)  LDD0595  [10]
 LDCM0279  AC2 HCT 116 C520(0.72); C24(0.86); C337(1.05); C203(1.07)  LDD0596  [10]
 LDCM0280  AC20 HCT 116 C24(0.93); C337(0.99); C203(1.16); C520(2.04)  LDD0597  [10]
 LDCM0281  AC21 HCT 116 C337(1.03); C203(1.23); C24(1.43); C520(1.66)  LDD0598  [10]
 LDCM0282  AC22 HCT 116 C337(0.95); C203(1.06); C24(1.30); C520(1.97)  LDD0599  [10]
 LDCM0283  AC23 HCT 116 C337(1.04); C24(1.10); C203(1.15); C520(2.10)  LDD0600  [10]
 LDCM0284  AC24 HCT 116 C337(0.90); C203(0.96); C24(1.04); C520(2.77)  LDD0601  [10]
 LDCM0285  AC25 HCT 116 C718(0.94); C203(0.94); C716(0.98); C337(1.03)  LDD0602  [10]
 LDCM0286  AC26 HCT 116 C520(0.91); C515(0.91); C716(0.97); C718(1.05)  LDD0603  [10]
 LDCM0287  AC27 HCT 116 C718(0.80); C716(0.88); C203(1.08); C337(1.11)  LDD0604  [10]
 LDCM0288  AC28 HCT 116 C718(0.89); C716(0.93); C520(1.01); C515(1.01)  LDD0605  [10]
 LDCM0289  AC29 HCT 116 C716(1.01); C718(1.04); C337(1.13); C203(1.30)  LDD0606  [10]
 LDCM0290  AC3 HCT 116 C520(0.74); C24(0.96); C203(0.97); C337(1.01)  LDD0607  [10]
 LDCM0291  AC30 HCT 116 C718(0.81); C716(0.88); C337(1.20); C24(1.29)  LDD0608  [10]
 LDCM0292  AC31 HCT 116 C718(0.89); C716(0.97); C337(1.12); C520(1.21)  LDD0609  [10]
 LDCM0293  AC32 HCT 116 C718(0.75); C716(0.93); C520(0.99); C515(0.99)  LDD0610  [10]
 LDCM0294  AC33 HCT 116 C718(0.74); C716(1.05); C337(1.09); C203(1.29)  LDD0611  [10]
 LDCM0295  AC34 HCT 116 C718(0.67); C716(0.92); C337(1.17); C24(1.58)  LDD0612  [10]
 LDCM0296  AC35 HCT 116 C24(0.89); C520(0.90); C515(0.90); C337(0.92)  LDD0613  [10]
 LDCM0297  AC36 HCT 116 C520(0.82); C515(0.82); C203(0.93); C337(0.97)  LDD0614  [10]
 LDCM0298  AC37 HCT 116 C520(0.91); C515(0.91); C337(0.95); C203(0.97)  LDD0615  [10]
 LDCM0299  AC38 HCT 116 C520(0.91); C515(0.91); C337(0.93); C203(1.01)  LDD0616  [10]
 LDCM0300  AC39 HCT 116 C520(0.50); C515(0.50); C337(1.02); C203(1.05)  LDD0617  [10]
 LDCM0301  AC4 HCT 116 C24(0.95); C520(1.01); C337(1.06); C203(1.33)  LDD0618  [10]
 LDCM0302  AC40 HCT 116 C520(0.92); C515(0.92); C337(1.06); C716(1.10)  LDD0619  [10]
 LDCM0303  AC41 HCT 116 C520(0.58); C515(0.58); C337(1.01); C24(1.08)  LDD0620  [10]
 LDCM0304  AC42 HCT 116 C520(0.70); C515(0.70); C337(0.97); C716(1.00)  LDD0621  [10]
 LDCM0305  AC43 HCT 116 C520(0.73); C515(0.73); C337(1.03); C203(1.19)  LDD0622  [10]
 LDCM0306  AC44 HCT 116 C520(0.66); C515(0.66); C337(1.01); C203(1.04)  LDD0623  [10]
 LDCM0307  AC45 HCT 116 C520(0.75); C515(0.75); C716(0.99); C718(1.07)  LDD0624  [10]
 LDCM0308  AC46 HCT 116 C716(0.62); C718(0.85); C337(0.97); C24(1.08)  LDD0625  [10]
 LDCM0309  AC47 HCT 116 C716(0.71); C718(0.82); C520(0.85); C515(0.85)  LDD0626  [10]
 LDCM0310  AC48 HCT 116 C716(0.65); C520(0.70); C515(0.70); C337(0.99)  LDD0627  [10]
 LDCM0311  AC49 HCT 116 C716(0.57); C718(0.88); C520(1.08); C515(1.08)  LDD0628  [10]
 LDCM0312  AC5 HCT 116 C24(0.91); C337(1.04); C520(1.08); C203(1.13)  LDD0629  [10]
 LDCM0313  AC50 HCT 116 C716(0.54); C718(0.75); C337(1.08); C520(1.15)  LDD0630  [10]
 LDCM0314  AC51 HCT 116 C716(0.56); C520(0.82); C515(0.82); C337(0.93)  LDD0631  [10]
 LDCM0315  AC52 HCT 116 C716(0.60); C718(0.79); C520(0.81); C515(0.81)  LDD0632  [10]
 LDCM0316  AC53 HCT 116 C716(0.76); C718(0.87); C520(1.00); C515(1.00)  LDD0633  [10]
 LDCM0317  AC54 HCT 116 C716(0.69); C520(0.74); C515(0.74); C718(0.79)  LDD0634  [10]
 LDCM0318  AC55 HCT 116 C718(0.89); C716(0.91); C337(1.11); C24(1.20)  LDD0635  [10]
 LDCM0319  AC56 HCT 116 C716(0.56); C718(0.87); C337(1.29); C24(1.47)  LDD0636  [10]
 LDCM0320  AC57 HCT 116 C716(0.29); C718(0.29); C24(0.61); C203(0.91)  LDD0637  [10]
 LDCM0321  AC58 HCT 116 C716(0.29); C718(0.29); C24(0.91); C203(1.02)  LDD0638  [10]
 LDCM0322  AC59 HCT 116 C716(0.29); C718(0.29); C203(0.96); C24(1.08)  LDD0639  [10]
 LDCM0323  AC6 HCT 116 C203(0.84); C716(0.97); C718(0.97); C24(1.09)  LDD0640  [10]
 LDCM0324  AC60 HCT 116 C716(0.35); C718(0.35); C24(0.92); C203(1.01)  LDD0641  [10]
 LDCM0325  AC61 HCT 116 C716(0.43); C718(0.43); C24(0.84); C203(0.86)  LDD0642  [10]
 LDCM0326  AC62 HCT 116 C716(0.30); C718(0.30); C203(0.92); C24(0.95)  LDD0643  [10]
 LDCM0327  AC63 HCT 116 C716(0.31); C718(0.31); C24(0.90); C203(0.95)  LDD0644  [10]
 LDCM0328  AC64 HCT 116 C716(0.30); C718(0.30); C24(0.79); C203(0.90)  LDD0645  [10]
 LDCM0329  AC65 HCT 116 C716(0.33); C718(0.33); C24(0.63); C203(1.07)  LDD0646  [10]
 LDCM0330  AC66 HCT 116 C716(0.38); C718(0.38); C24(0.53); C203(0.92)  LDD0647  [10]
 LDCM0331  AC67 HCT 116 C716(0.37); C718(0.37); C24(0.64); C203(1.01)  LDD0648  [10]
 LDCM0332  AC68 HCT 116 C520(0.64); C515(0.64); C716(0.74); C718(0.74)  LDD0649  [10]
 LDCM0333  AC69 HCT 116 C716(0.69); C718(0.69); C520(0.77); C515(0.77)  LDD0650  [10]
 LDCM0334  AC7 HCT 116 C520(0.70); C515(0.71); C203(0.95); C24(0.96)  LDD0651  [10]
 LDCM0335  AC70 HCT 116 C520(0.54); C515(0.54); C716(0.72); C718(0.72)  LDD0652  [10]
 LDCM0336  AC71 HCT 116 C520(0.68); C515(0.68); C716(0.85); C718(0.85)  LDD0653  [10]
 LDCM0337  AC72 HCT 116 C716(0.66); C718(0.66); C520(0.89); C515(0.89)  LDD0654  [10]
 LDCM0338  AC73 HCT 116 C716(0.65); C718(0.65); C520(1.02); C515(1.02)  LDD0655  [10]
 LDCM0339  AC74 HCT 116 C716(0.90); C718(0.90); C520(0.99); C515(0.99)  LDD0656  [10]
 LDCM0340  AC75 HCT 116 C716(0.75); C718(0.75); C520(1.11); C515(1.11)  LDD0657  [10]
 LDCM0341  AC76 HCT 116 C716(0.72); C718(0.72); C520(0.76); C515(0.76)  LDD0658  [10]
 LDCM0342  AC77 HCT 116 C716(0.67); C718(0.67); C520(0.73); C515(0.73)  LDD0659  [10]
 LDCM0343  AC78 HCT 116 C520(0.80); C515(0.80); C716(0.90); C718(0.90)  LDD0660  [10]
 LDCM0344  AC79 HCT 116 C716(0.63); C718(0.63); C520(0.67); C515(0.67)  LDD0661  [10]
 LDCM0345  AC8 HCT 116 C520(0.83); C24(0.85); C203(0.90); C515(0.92)  LDD0662  [10]
 LDCM0346  AC80 HCT 116 C520(0.72); C515(0.72); C716(0.72); C718(0.72)  LDD0663  [10]
 LDCM0347  AC81 HCT 116 C520(0.67); C515(0.67); C716(0.83); C718(0.83)  LDD0664  [10]
 LDCM0348  AC82 HCT 116 C520(0.76); C515(0.76); C716(0.83); C718(0.83)  LDD0665  [10]
 LDCM0349  AC83 HCT 116 C716(0.65); C718(0.77); C337(1.31); C24(1.49)  LDD0666  [10]
 LDCM0350  AC84 HCT 116 C716(0.61); C718(0.75); C24(1.26); C337(1.30)  LDD0667  [10]
 LDCM0351  AC85 HCT 116 C716(0.76); C718(0.80); C337(1.14); C24(1.15)  LDD0668  [10]
 LDCM0352  AC86 HCT 116 C716(0.69); C718(0.76); C337(1.13); C24(1.15)  LDD0669  [10]
 LDCM0353  AC87 HCT 116 C716(0.95); C718(0.96); C337(1.01); C24(1.06)  LDD0670  [10]
 LDCM0354  AC88 HCT 116 C716(0.78); C718(0.87); C337(1.07); C24(1.12)  LDD0671  [10]
 LDCM0355  AC89 HCT 116 C716(0.51); C718(0.63); C337(1.13); C24(1.24)  LDD0672  [10]
 LDCM0357  AC90 HCT 116 C337(1.03); C24(1.05); C203(1.23); C716(1.59)  LDD0674  [10]
 LDCM0358  AC91 HCT 116 C716(0.56); C718(0.66); C24(1.02); C337(1.27)  LDD0675  [10]
 LDCM0359  AC92 HCT 116 C716(0.56); C718(0.73); C24(0.95); C337(1.18)  LDD0676  [10]
 LDCM0360  AC93 HCT 116 C716(0.62); C718(0.75); C24(0.84); C337(1.03)  LDD0677  [10]
 LDCM0361  AC94 HCT 116 C716(0.78); C24(0.80); C718(0.83); C203(1.02)  LDD0678  [10]
 LDCM0362  AC95 HCT 116 C24(0.75); C716(0.79); C718(0.79); C337(1.02)  LDD0679  [10]
 LDCM0363  AC96 HCT 116 C716(0.54); C718(0.65); C24(0.77); C337(1.09)  LDD0680  [10]
 LDCM0364  AC97 HCT 116 C716(0.50); C718(0.58); C24(1.09); C337(1.17)  LDD0681  [10]
 LDCM0365  AC98 HCT 116 C520(0.37); C515(0.37); C716(0.60); C718(0.69)  LDD0682  [10]
 LDCM0366  AC99 HCT 116 C520(0.82); C515(0.82); C718(0.89); C716(0.89)  LDD0683  [10]
 LDCM0248  AKOS034007472 HCT 116 C520(0.62); C203(0.86); C24(0.61); C337(1.07)  LDD0565  [10]
 LDCM0356  AKOS034007680 HCT 116 C515(0.74); C203(0.75); C520(0.78); C24(1.02)  LDD0673  [10]
 LDCM0275  AKOS034007705 HCT 116 C24(0.60); C515(0.70); C716(0.87); C718(0.87)  LDD0592  [10]
 LDCM0020  ARS-1620 HCC44 C203(1.30); C24(1.11); C337(0.96)  LDD0078  [10]
 LDCM0367  CL1 HCT 116 C24(0.93); C718(0.98); C203(1.33)  LDD0684  [10]
 LDCM0368  CL10 HCT 116 C718(1.17); C24(1.55); C203(2.00)  LDD0685  [10]
 LDCM0369  CL100 HCT 116 C520(0.92); C24(1.00); C203(1.01); C337(1.06)  LDD0686  [10]
 LDCM0370  CL101 HCT 116 C24(0.84); C203(0.86); C515(0.88); C520(0.92)  LDD0687  [10]
 LDCM0371  CL102 HCT 116 C520(0.68); C515(0.85); C24(0.92); C203(0.95)  LDD0688  [10]
 LDCM0372  CL103 HCT 116 C24(0.71); C203(0.75); C515(0.77); C520(0.86)  LDD0689  [10]
 LDCM0373  CL104 HCT 116 C24(0.72); C203(0.79); C520(1.08); C337(1.13)  LDD0690  [10]
 LDCM0374  CL105 HCT 116 C337(1.12); C24(1.18); C203(1.25); C520(1.67)  LDD0691  [10]
 LDCM0375  CL106 HCT 116 C24(1.15); C337(1.22); C203(1.50); C520(4.00)  LDD0692  [10]
 LDCM0376  CL107 HCT 116 C24(1.18); C337(1.21); C203(1.38); C520(3.36)  LDD0693  [10]
 LDCM0377  CL108 HCT 116 C24(1.12); C337(1.23); C203(1.47); C520(6.14)  LDD0694  [10]
 LDCM0378  CL109 HCT 116 C337(0.99); C24(1.29); C203(1.31); C520(1.85)  LDD0695  [10]
 LDCM0379  CL11 HCT 116 C718(0.89); C203(1.75); C24(1.90)  LDD0696  [10]
 LDCM0380  CL110 HCT 116 C337(1.14); C24(1.28); C203(1.48); C520(2.57)  LDD0697  [10]
 LDCM0381  CL111 HCT 116 C24(1.02); C337(1.05); C203(1.31); C520(2.57)  LDD0698  [10]
 LDCM0382  CL112 HCT 116 C520(0.67); C515(0.67); C718(0.85); C716(0.90)  LDD0699  [10]
 LDCM0383  CL113 HCT 116 C718(0.71); C716(0.83); C520(1.21); C515(1.21)  LDD0700  [10]
 LDCM0384  CL114 HCT 116 C718(0.90); C716(0.98); C520(1.02); C515(1.02)  LDD0701  [10]
 LDCM0385  CL115 HCT 116 C718(0.87); C716(0.92); C520(0.97); C515(0.97)  LDD0702  [10]
 LDCM0386  CL116 HCT 116 C520(0.84); C515(0.84); C718(0.95); C716(1.00)  LDD0703  [10]
 LDCM0387  CL117 HCT 116 C520(0.88); C515(0.88); C337(1.29); C203(1.39)  LDD0704  [10]
 LDCM0388  CL118 HCT 116 C520(0.57); C515(0.57); C24(0.91); C337(1.01)  LDD0705  [10]
 LDCM0389  CL119 HCT 116 C520(0.82); C515(0.82); C337(1.02); C716(1.09)  LDD0706  [10]
 LDCM0390  CL12 HCT 116 C718(0.90); C24(1.14); C203(1.16)  LDD0707  [10]
 LDCM0391  CL120 HCT 116 C520(0.55); C515(0.55); C24(0.94); C337(1.04)  LDD0708  [10]
 LDCM0392  CL121 HCT 116 C718(0.58); C716(0.65); C24(1.03); C337(1.04)  LDD0709  [10]
 LDCM0393  CL122 HCT 116 C716(0.71); C520(0.78); C515(0.78); C718(0.88)  LDD0710  [10]
 LDCM0394  CL123 HCT 116 C718(0.83); C716(0.87); C520(1.00); C515(1.00)  LDD0711  [10]
 LDCM0395  CL124 HCT 116 C716(0.66); C718(0.84); C520(1.08); C515(1.08)  LDD0712  [10]
 LDCM0396  CL125 HCT 116 C24(0.72); C716(0.84); C718(0.84); C203(1.04)  LDD0713  [10]
 LDCM0397  CL126 HCT 116 C716(0.79); C718(0.79); C24(0.86); C203(1.16)  LDD0714  [10]
 LDCM0398  CL127 HCT 116 C716(0.60); C718(0.60); C24(0.79); C203(0.99)  LDD0715  [10]
 LDCM0399  CL128 HCT 116 C716(0.28); C718(0.28); C203(0.83); C24(0.93)  LDD0716  [10]
 LDCM0400  CL13 HCT 116 C718(1.04); C203(1.28); C24(1.48)  LDD0717  [10]
 LDCM0401  CL14 HCT 116 C24(0.91); C718(1.06); C203(1.10)  LDD0718  [10]
 LDCM0402  CL15 HCT 116 C718(0.92); C203(1.35); C24(1.84)  LDD0719  [10]
 LDCM0403  CL16 HCT 116 C716(0.75); C718(0.75); C337(1.04); C24(1.10)  LDD0720  [10]
 LDCM0404  CL17 HCT 116 C716(0.76); C718(0.76); C337(1.03); C24(1.08)  LDD0721  [10]
 LDCM0405  CL18 HCT 116 C716(0.73); C718(0.73); C337(1.03); C24(1.22)  LDD0722  [10]
 LDCM0406  CL19 HCT 116 C716(0.71); C718(0.71); C24(0.87); C203(1.08)  LDD0723  [10]
 LDCM0407  CL2 HCT 116 C718(0.86); C24(0.92); C203(1.37)  LDD0724  [10]
 LDCM0408  CL20 HCT 116 C716(0.53); C718(0.53); C24(0.75); C337(1.07)  LDD0725  [10]
 LDCM0409  CL21 HCT 116 C716(0.61); C718(0.61); C24(0.97); C337(1.21)  LDD0726  [10]
 LDCM0410  CL22 HCT 116 C716(0.81); C718(0.81); C24(1.14); C203(1.46)  LDD0727  [10]
 LDCM0411  CL23 HCT 116 C716(0.58); C718(0.58); C24(0.73); C337(1.07)  LDD0728  [10]
 LDCM0412  CL24 HCT 116 C716(0.67); C718(0.67); C24(1.07); C337(1.26)  LDD0729  [10]
 LDCM0413  CL25 HCT 116 C203(1.65); C24(0.95); C337(1.15); C716(0.70)  LDD0730  [10]
 LDCM0414  CL26 HCT 116 C203(1.35); C24(0.93); C337(1.10); C716(0.64)  LDD0731  [10]
 LDCM0415  CL27 HCT 116 C203(1.38); C24(0.76); C337(1.07); C716(0.63)  LDD0732  [10]
 LDCM0416  CL28 HCT 116 C203(1.15); C24(0.79); C337(1.10); C716(0.54)  LDD0733  [10]
 LDCM0417  CL29 HCT 116 C203(1.16); C24(0.69); C337(1.13); C716(0.61)  LDD0734  [10]
 LDCM0418  CL3 HCT 116 C203(1.10); C24(1.03); C718(1.22)  LDD0735  [10]
 LDCM0419  CL30 HCT 116 C203(1.08); C24(0.69); C337(1.03); C716(0.75)  LDD0736  [10]
 LDCM0420  CL31 HCT 116 C203(1.18); C24(1.11); C337(1.04); C716(0.86)  LDD0737  [10]
 LDCM0421  CL32 HCT 116 C203(1.20); C24(1.18); C337(0.99); C716(0.50)  LDD0738  [10]
 LDCM0422  CL33 HCT 116 C203(1.79); C24(1.09); C337(1.34); C716(0.57)  LDD0739  [10]
 LDCM0423  CL34 HCT 116 C203(1.44); C24(1.65); C337(1.19); C716(0.40)  LDD0740  [10]
 LDCM0424  CL35 HCT 116 C203(1.33); C24(1.18); C337(1.02); C716(0.36)  LDD0741  [10]
 LDCM0425  CL36 HCT 116 C203(1.27); C24(1.32); C337(1.08); C716(0.33)  LDD0742  [10]
 LDCM0426  CL37 HCT 116 C203(1.56); C24(1.21); C337(1.13); C716(0.40)  LDD0743  [10]
 LDCM0428  CL39 HCT 116 C203(1.69); C24(2.09); C337(1.14); C716(0.40)  LDD0745  [10]
 LDCM0429  CL4 HCT 116 C203(1.21); C24(1.02); C718(0.94)  LDD0746  [10]
 LDCM0430  CL40 HCT 116 C203(1.38); C24(1.31); C337(1.19); C716(0.33)  LDD0747  [10]
 LDCM0431  CL41 HCT 116 C203(1.32); C24(1.10); C337(1.03); C716(0.36)  LDD0748  [10]
 LDCM0432  CL42 HCT 116 C203(1.86); C24(2.13); C337(1.32); C716(0.50)  LDD0749  [10]
 LDCM0433  CL43 HCT 116 C203(1.51); C24(1.44); C337(1.20); C716(0.37)  LDD0750  [10]
 LDCM0434  CL44 HCT 116 C203(1.56); C24(1.57); C337(1.11); C716(0.36)  LDD0751  [10]
 LDCM0435  CL45 HCT 116 C203(1.60); C24(1.48); C337(1.18); C716(0.36)  LDD0752  [10]
 LDCM0436  CL46 HCT 116 C520(2.00); C203(1.03); C24(0.93); C337(0.89)  LDD0753  [10]
 LDCM0437  CL47 HCT 116 C520(1.19); C203(0.94); C24(1.08); C337(0.98)  LDD0754  [10]
 LDCM0438  CL48 HCT 116 C520(1.20); C203(0.88); C24(0.89); C337(0.93)  LDD0755  [10]
 LDCM0439  CL49 HCT 116 C520(2.81); C203(0.89); C24(0.98); C337(0.90)  LDD0756  [10]
 LDCM0440  CL5 HCT 116 C203(1.02); C24(1.10); C718(1.01)  LDD0757  [10]
 LDCM0441  CL50 HCT 116 C520(1.74); C203(1.14); C24(0.96); C337(0.87)  LDD0758  [10]
 LDCM0442  CL51 HCT 116 C520(1.71); C203(0.92); C24(0.96); C337(0.92)  LDD0759  [10]
 LDCM0443  CL52 HCT 116 C520(1.39); C203(0.96); C24(0.97); C337(1.01)  LDD0760  [10]
 LDCM0444  CL53 HCT 116 C520(2.13); C203(1.11); C24(0.84); C337(0.93)  LDD0761  [10]
 LDCM0445  CL54 HCT 116 C520(2.65); C203(0.91); C24(1.02); C337(0.90)  LDD0762  [10]
 LDCM0446  CL55 HCT 116 C520(2.48); C203(0.90); C24(0.89); C337(0.86)  LDD0763  [10]
 LDCM0447  CL56 HCT 116 C520(0.94); C203(0.87); C24(0.84); C337(1.00)  LDD0764  [10]
 LDCM0448  CL57 HCT 116 C520(1.68); C203(0.93); C24(0.83); C337(0.89)  LDD0765  [10]
 LDCM0449  CL58 HCT 116 C520(1.70); C203(0.97); C24(0.78); C337(0.87)  LDD0766  [10]
 LDCM0450  CL59 HCT 116 C520(1.21); C203(0.91); C24(0.91); C337(0.93)  LDD0767  [10]
 LDCM0451  CL6 HCT 116 C203(1.26); C24(1.19); C718(1.00)  LDD0768  [10]
 LDCM0452  CL60 HCT 116 C520(1.84); C203(1.13); C24(0.91); C337(0.94)  LDD0769  [10]
 LDCM0453  CL61 HCT 116 C203(1.12); C24(1.01); C337(1.01); C716(0.95)  LDD0770  [10]
 LDCM0454  CL62 HCT 116 C203(0.94); C24(2.09); C337(1.03); C716(1.08)  LDD0771  [10]
 LDCM0455  CL63 HCT 116 C203(1.07); C24(1.56); C337(0.96); C716(0.88)  LDD0772  [10]
 LDCM0456  CL64 HCT 116 C203(1.26); C24(1.23); C337(1.08); C716(0.70)  LDD0773  [10]
 LDCM0457  CL65 HCT 116 C203(1.07); C24(1.31); C337(1.05); C716(0.96)  LDD0774  [10]
 LDCM0458  CL66 HCT 116 C203(1.33); C24(1.53); C337(1.17); C716(0.72)  LDD0775  [10]
 LDCM0459  CL67 HCT 116 C203(1.10); C24(1.19); C337(1.07); C716(0.76)  LDD0776  [10]
 LDCM0460  CL68 HCT 116 C203(1.04); C24(1.53); C337(1.15); C716(0.86)  LDD0777  [10]
 LDCM0461  CL69 HCT 116 C203(1.03); C24(1.33); C337(1.02); C716(0.81)  LDD0778  [10]
 LDCM0462  CL7 HCT 116 C203(1.28); C24(1.22); C718(1.06)  LDD0779  [10]
 LDCM0463  CL70 HCT 116 C203(1.08); C24(1.19); C337(1.02); C716(0.79)  LDD0780  [10]
 LDCM0464  CL71 HCT 116 C203(0.99); C24(1.37); C337(0.98); C716(0.85)  LDD0781  [10]
 LDCM0465  CL72 HCT 116 C203(1.09); C24(1.41); C337(1.01); C716(0.90)  LDD0782  [10]
 LDCM0466  CL73 HCT 116 C203(1.09); C24(1.07); C337(1.07); C716(0.73)  LDD0783  [10]
 LDCM0467  CL74 HCT 116 C203(1.22); C24(1.20); C337(1.06); C716(0.74)  LDD0784  [10]
 LDCM0469  CL76 HCT 116 C203(1.10); C24(1.15); C337(1.09)  LDD0786  [10]
 LDCM0470  CL77 HCT 116 C203(1.06); C24(1.03); C337(1.08)  LDD0787  [10]
 LDCM0471  CL78 HCT 116 C203(1.12); C24(1.38); C337(1.11)  LDD0788  [10]
 LDCM0472  CL79 HCT 116 C203(0.96); C24(1.13); C337(1.23)  LDD0789  [10]
 LDCM0473  CL8 HCT 116 C203(2.54); C24(1.40); C718(1.09)  LDD0790  [10]
 LDCM0474  CL80 HCT 116 C203(0.95); C24(0.99); C337(1.02)  LDD0791  [10]
 LDCM0475  CL81 HCT 116 C203(0.89); C24(0.96); C337(1.11)  LDD0792  [10]
 LDCM0476  CL82 HCT 116 C203(0.87); C24(1.24); C337(1.36)  LDD0793  [10]
 LDCM0477  CL83 HCT 116 C203(1.08); C24(1.51); C337(1.28)  LDD0794  [10]
 LDCM0478  CL84 HCT 116 C203(1.01); C24(1.71); C337(1.45)  LDD0795  [10]
 LDCM0479  CL85 HCT 116 C203(0.97); C24(1.09); C337(1.05)  LDD0796  [10]
 LDCM0480  CL86 HCT 116 C203(1.05); C24(1.12); C337(0.95)  LDD0797  [10]
 LDCM0481  CL87 HCT 116 C203(0.89); C24(0.94); C337(1.07)  LDD0798  [10]
 LDCM0482  CL88 HCT 116 C203(1.00); C24(0.97); C337(1.21)  LDD0799  [10]
 LDCM0483  CL89 HCT 116 C203(0.91); C24(1.37); C337(1.65)  LDD0800  [10]
 LDCM0484  CL9 HCT 116 C203(1.42); C24(1.38); C718(0.83)  LDD0801  [10]
 LDCM0485  CL90 HCT 116 C203(1.27); C24(0.87); C337(1.23)  LDD0802  [10]
 LDCM0486  CL91 HCT 116 C520(0.63); C203(1.34); C24(1.06); C337(1.06)  LDD0803  [10]
 LDCM0487  CL92 HCT 116 C520(0.53); C203(0.99); C24(1.26); C337(1.20)  LDD0804  [10]
 LDCM0488  CL93 HCT 116 C520(0.89); C203(1.16); C24(1.18); C337(1.05)  LDD0805  [10]
 LDCM0489  CL94 HCT 116 C520(1.35); C203(1.33); C24(1.15); C337(1.08)  LDD0806  [10]
 LDCM0490  CL95 HCT 116 C520(0.81); C203(1.55); C24(1.41); C337(1.09)  LDD0807  [10]
 LDCM0491  CL96 HCT 116 C520(0.68); C203(1.35); C24(1.18); C337(1.11)  LDD0808  [10]
 LDCM0492  CL97 HCT 116 C520(0.85); C203(1.33); C24(1.07); C337(1.11)  LDD0809  [10]
 LDCM0493  CL98 HCT 116 C520(0.96); C203(1.51); C24(1.14); C337(1.14)  LDD0810  [10]
 LDCM0494  CL99 HCT 116 C520(0.96); C203(1.15); C24(0.86); C337(1.11)  LDD0811  [10]
 LDCM0495  E2913 HEK-293T C24(1.02); C337(0.99); C98(0.98); C203(1.05)  LDD1698  [18]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C615(1.94)  LDD1702  [4]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [9]
 LDCM0625  F8 Ramos C24(1.44)  LDD2187  [19]
 LDCM0572  Fragment10 Ramos C24(1.60)  LDD2189  [19]
 LDCM0573  Fragment11 Ramos C24(0.68)  LDD2190  [19]
 LDCM0574  Fragment12 Ramos C24(1.46)  LDD2191  [19]
 LDCM0575  Fragment13 Ramos C24(1.02)  LDD2192  [19]
 LDCM0576  Fragment14 Ramos C24(0.92)  LDD2193  [19]
 LDCM0579  Fragment20 Ramos C24(0.81)  LDD2194  [19]
 LDCM0580  Fragment21 Ramos C24(1.53)  LDD2195  [19]
 LDCM0582  Fragment23 Ramos C24(0.75)  LDD2196  [19]
 LDCM0578  Fragment27 Ramos C24(0.81)  LDD2197  [19]
 LDCM0586  Fragment28 Ramos C24(0.76)  LDD2198  [19]
 LDCM0588  Fragment30 Ramos C24(1.22)  LDD2199  [19]
 LDCM0589  Fragment31 Ramos C24(0.74)  LDD2200  [19]
 LDCM0590  Fragment32 Ramos C24(1.34)  LDD2201  [19]
 LDCM0468  Fragment33 HCT 116 C203(0.91); C24(1.49); C337(0.99); C716(0.78)  LDD0785  [10]
 LDCM0596  Fragment38 Ramos C24(0.68)  LDD2203  [19]
 LDCM0566  Fragment4 Ramos C24(0.65)  LDD2184  [19]
 LDCM0427  Fragment51 HCT 116 C203(1.97); C24(1.82); C337(1.29); C716(0.42)  LDD0744  [10]
 LDCM0610  Fragment52 Ramos C24(1.27)  LDD2204  [19]
 LDCM0614  Fragment56 Ramos C24(1.22)  LDD2205  [19]
 LDCM0569  Fragment7 Jurkat _(20.00)  LDD1485  [6]
 LDCM0571  Fragment9 Ramos C24(1.10)  LDD2188  [19]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [3]
 LDCM0022  KB02 HCT 116 C24(1.87)  LDD0080  [10]
 LDCM0023  KB03 HCT 116 C24(1.33)  LDD0081  [10]
 LDCM0024  KB05 HCT 116 C24(2.32)  LDD0082  [10]
 LDCM0030  Luteolin HEK-293T 4.31  LDD0182  [7]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C24(0.54)  LDD2089  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C24(0.89)  LDD2109  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C24(1.26)  LDD2111  [4]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C24(0.80)  LDD2118  [4]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C24(1.14)  LDD2120  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C24(0.97)  LDD2125  [4]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C24(1.30)  LDD2126  [4]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C24(0.81)  LDD2128  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C24(0.82)  LDD2137  [4]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C24(1.24)  LDD2143  [4]
 LDCM0003  Sulforaphane MDA-MB-231 1.05  LDD0160  [5]
 LDCM0021  THZ1 HCT 116 C24(1.11); C203(0.82); C337(1.13)  LDD2173  [10]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Acyl-coenzyme A synthetase ACSM1, mitochondrial (ACSM1) ATP-dependent AMP-binding enzyme family Q08AH1
Serine/threonine-protein kinase 35 (STK35) Ser/Thr protein kinase family Q8TDR2
Serine/threonine-protein kinase PLK4 (PLK4) Ser/Thr protein kinase family O00444
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Synaptotagmin-like protein 4 (SYTL4) . Q96C24
Transcription factor
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger and BTB domain-containing protein 16 (ZBTB16) Krueppel C2H2-type zinc-finger protein family Q05516
Zinc finger protein 48 (ZNF48) Krueppel C2H2-type zinc-finger protein family Q96MX3
Zinc finger protein 497 (ZNF497) Krueppel C2H2-type zinc-finger protein family Q6ZNH5
Zinc finger protein 648 (ZNF648) Krueppel C2H2-type zinc-finger protein family Q5T619
Zinc finger protein 835 (ZNF835) Krueppel C2H2-type zinc-finger protein family Q9Y2P0
Other
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAPL1) ATG8 family Q9H0R8
Gamma-aminobutyric acid receptor-associated protein-like 2 (GABARAPL2) ATG8 family P60520
Bystin (BYSL) Bystin family Q13895
Protein FAM161A (FAM161A) FAM161 family Q3B820
Pre-mRNA-splicing factor 18 (PRPF18) PRP18 family Q99633
Transcription elongation factor A protein 2 (TCEA2) TFS-II family Q15560
Microspherule protein 1 (MCRS1) . Q96EZ8
Ras-specific guanine nucleotide-releasing factor RalGPS2 (RALGPS2) . Q86X27
TRAF3-interacting JNK-activating modulator (TRAF3IP3) . Q9Y228
U4/U6 small nuclear ribonucleoprotein Prp3 (PRPF3) . O43395

References

1 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chem Commun (Camb). 2017 May 4;53(37):5182-5185. doi: 10.1039/c6cc08797c.
Mass spectrometry data entry: PXD006279
6 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
7 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
8 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
9 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
14 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
15 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
16 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
17 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
19 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578