Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C361  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 96 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03842  Squalene synthase (FDFT1) 82.1
 LDTP10101  Peptidyl-prolyl cis-trans isomerase FKBP10 (FKBP10) 75.1
 LDTP03540  Heme oxygenase 2 (HMOX2) 61.8
 LDTP08598  NAD-dependent protein deacetylase sirtuin-2 (SIRT2) 61.8
 LDTP01562  Peptidyl-prolyl cis-trans isomerase FKBP9 (FKBP9) 60.5
 LDTP03198  Ferrochelatase, mitochondrial (FECH) 52.3
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 45.6
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 42.8
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 37.8
 LDTP16070  Epimerase family protein SDR39U1 (SDR39U1) 36.0
 LDTP04689  Adenosine kinase (ADK) 34.3
 LDTP01687  Apoptosis-inducing factor 1, mitochondrial (AIFM1) 34.3
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 34.1
 LDTP03692  Bifunctional epoxide hydrolase 2 (EPHX2) 33.6
 LDTP13938  Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial (COQ6) 33.4
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 32.9
 LDTP01419  Retinal dehydrogenase 2 (ALDH1A2) 32.9
 LDTP02254  ATP-dependent translocase ABCB1 (ABCB1) 32.7
 LDTP01769  Dihydrofolate reductase (DHFR) 30.7
 LDTP12197  Ethanolamine kinase 1 (ETNK1) 30.7
 LDTP15484  Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) 29.9
 LDTP09074  UDP-glucuronic acid decarboxylase 1 (UXS1) 27.7
 LDTP03560  Aldehyde dehydrogenase X, mitochondrial (ALDH1B1) 26.9
 LDTP04327  Cytosolic purine 5'-nucleotidase (NT5C2) 26.9
 LDTP12603  NAD-dependent protein deacetylase sirtuin-3, mitochondrial (SIRT3) 26.5
 LDTP05346  Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial (ALDH6A1) 26.4
 LDTP11081  NAD-capped RNA hydrolase NUDT12 (NUDT12) 26.2
 LDTP12628  Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) 26.0
 LDTP00697  Cytochrome b5 type B (CYB5B) 25.8
 LDTP13240  Poly [ADP-ribose] polymerase 2 (PARP2) 25.8
 LDTP00988  Protein O-GlcNAcase (OGA) 25.8
 LDTP05640  Secernin-1 (SCRN1) 25.8
 LDTP01803  Adenosine deaminase (ADA) 25.6
 LDTP03103  Glutathione S-transferase Mu 3 (GSTM3) 25.3
 LDTP04114  E3 ubiquitin-protein ligase NEDD4 (NEDD4) 24.6
 LDTP04471  Ribosomal protein S6 kinase alpha-3 (RPS6KA3) 23.9
 LDTP06384  Ribosomal protein S6 kinase alpha-1 (RPS6KA1) 23.4
 LDTP12040  Prostaglandin E synthase 2 (PTGES2) 23.3
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 23.1
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 22.5
 LDTP09874  Endoplasmic reticulum protein SC65 (P3H4) 22.3
 LDTP09256  Putative phospholipase B-like 2 (PLBD2) 22.0
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 21.9
 LDTP04581  Holocytochrome c-type synthase (HCCS) 21.7
 LDTP03787  Choline kinase alpha (CHKA) 21.4
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 21.4
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 21.3
 LDTP13703  Histone lysine demethylase PHF8 (PHF8) 21.0
 LDTP08617  Patatin-like phospholipase domain-containing protein 6 (PNPLA6) 21.0
 LDTP02375  Poly [ADP-ribose] polymerase 1 (PARP1) 21.0
 LDTP05724  Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1) 20.8
 LDTP01515  NADH dehydrogenase 1 beta subcomplex subunit 8, mitochondrial (NDUFB8) 20.7
 LDTP10785  Ubiquitin carboxyl-terminal hydrolase 28 (USP28) 20.5
 LDTP02385  Leukotriene A-4 hydrolase (LTA4H) 20.1
 LDTP13620  Lysosomal thioesterase PPT2 (PPT2) 20.1
 LDTP12720  Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) 20.0
 LDTP10329  Ceramide synthase 2 (CERS2) 19.8
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 19.8
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 19.7
 LDTP03671  Multidrug resistance-associated protein 1 (ABCC1) 19.7
 LDTP01665  Geranylgeranyl pyrophosphate synthase (GGPS1) 19.4
 LDTP12868  Endoplasmic reticulum aminopeptidase 1 (ERAP1) 19.3
 LDTP02123  Protein kinase C beta type (PRKCB) 19.2
 LDTP07679  Lysocardiolipin acyltransferase 1 (LCLAT1) 19.0
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 19.0
 LDTP05066  Signal peptidase complex catalytic subunit SEC11A (SEC11A) 19.0
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 18.9
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 18.9
 LDTP04248  Deoxyhypusine synthase (DHPS) 18.8
 LDTP14218  Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) 18.6
 LDTP12293  Adipocyte plasma membrane-associated protein (APMAP) 18.5
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 18.5
 LDTP06343  Serine/threonine-protein phosphatase 2A activator (PTPA) 18.5
 LDTP02640  X-ray repair cross-complementing protein 6 (XRCC6) 18.5
 LDTP09088  Phospholipase A2 group XV (PLA2G15) 18.4
 LDTP10032  7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) 18.3
 LDTP08017  Endoplasmic reticulum metallopeptidase 1 (ERMP1) 18.3
 LDTP07259  N-alpha-acetyltransferase 35, NatC auxiliary subunit (NAA35) 18.3
 LDTP05862  NAD(P) transhydrogenase, mitochondrial (NNT) 18.1
 LDTP06849  Prolyl endopeptidase-like (PREPL) 18.1
 LDTP05240  Transcription initiation factor IIB (GTF2B) 18.1
 LDTP01245  Enoyl-CoA delta isomerase 2 (ECI2) 18.0
 LDTP02757  Cytochrome b-c1 complex subunit 7 (UQCRB) 17.9
 LDTP06307  Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1) 17.9
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 17.9
 LDTP00836  ATPase GET3 (GET3) 17.6
 LDTP12573  E3 ubiquitin-protein ligase RAD18 (RAD18) 17.6
 LDTP05476  3-ketodihydrosphingosine reductase (KDSR) 17.5
 LDTP04299  Dual specificity protein kinase CLK3 (CLK3) 17.5
 LDTP07525  Protein arginine N-methyltransferase 9 (PRMT9) 17.5
 LDTP03607  RAC-alpha serine/threonine-protein kinase (AKT1) 17.5
 LDTP12227  Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (MCCC2) 17.4
 LDTP15422  Prostaglandin reductase 3 (PTGR3) 17.3
 LDTP03608  RAC-beta serine/threonine-protein kinase (AKT2) 17.1
 LDTP06617  Ceramide glucosyltransferase (UGCG) 17.0
 LDTP13751  Exonuclease 1 (EXO1) 17.0
Transporter and channel
Click to Show/Hide to Show 28 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 76.6
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 63.1
 LDTP01804  ATP synthase subunit a (MT-ATP6) 46.2
 LDTP11095  Mitochondrial 2-oxodicarboxylate carrier (SLC25A21) 38.3
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 38.1
 LDTP10985  Equilibrative nucleoside transporter 1 (SLC29A1) 29.7
 LDTP03546  Translocator protein (TSPO) 27.9
 LDTP06198  Major facilitator superfamily domain-containing protein 10 (MFSD10) 24.6
 LDTP03559  High affinity cationic amino acid transporter 1 (SLC7A1) 23.3
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 22.9
 LDTP10621  Sideroflexin-2 (SFXN2) 21.3
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 21.1
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 20.7
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 20.3
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 20.1
 LDTP15967  Tetraspanin-10 (TSPAN10) 20.0
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 20.0
 LDTP02071  Amyloid-beta precursor protein (APP) 19.6
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 19.2
 LDTP12043  Phosphorylated adapter RNA export protein (PHAX) 18.5
 LDTP07667  Transmembrane protein 205 (TMEM205) 18.4
 LDTP14200  Mitochondrial ornithine transporter 1 (SLC25A15) 18.1
 LDTP11116  45 kDa calcium-binding protein (SDF4) 18.0
 LDTP14178  Heme transporter FLVCR1 (FLVCR1) 17.5
 LDTP03839  Nuclear pore glycoprotein p62 (NUP62) 17.4
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 17.0
 LDTP01200  Peroxisomal membrane protein PEX14 (PEX14) 17.0
 LDTP07397  THO complex subunit 7 homolog (THOC7) 17.0
GPCR
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP15303  Membrane progestin receptor alpha (PAQR7) 28.2
Other
Click to Show/Hide to Show 81 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP01362  Survival of motor neuron-related-splicing factor 30 (SMNDC1) 64.0
 LDTP11533  Oxysterol-binding protein-related protein 6 (OSBPL6) 61.8
 LDTP13606  Mammalian ependymin-related protein 1 (EPDR1) 45.3
 LDTP00871  Microtubule nucleation factor SSNA1 (SSNA1) 42.5
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 40.5
 LDTP19860  Coiled-coil domain-containing protein 97 (CCDC97) 40.2
 LDTP16078  Heme-binding protein 1 (HEBP1) 39.4
 LDTP15623  Neuferricin (CYB5D2) 36.5
 LDTP13902  Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) 34.5
 LDTP01652  Centrosomal protein 43 (CEP43) 34.1
 LDTP00105  Protein unc-119 homolog B (UNC119B) 33.6
 LDTP06022  Cold-inducible RNA-binding protein (CIRBP) 32.0
 LDTP06097  Reticulocalbin-2 (RCN2) 32.0
 LDTP05226  RNA-binding protein 3 (RBM3) 32.0
 LDTP14259  Testis-expressed protein 264 (TEX264) 29.4
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 29.2
 LDTP03612  Bifunctional purine biosynthesis protein ATIC (ATIC) 27.1
 LDTP02124  Keratin, type I cytoskeletal 18 (KRT18) 26.5
 LDTP09850  Proline-rich protein PRCC (PRCC) 26.0
 LDTP03850  RNA-binding motif protein, X chromosome (RBMX) 25.8
 LDTP03614  Heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3) 25.5
 LDTP05277  Protein SET (SET) 24.8
 LDTP12377  Mediator of RNA polymerase II transcription subunit 4 (MED4) 24.3
 LDTP19963  TraB domain-containing protein (TRABD) 24.1
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 23.9
 LDTP03247  Eukaryotic translation initiation factor 4B (EIF4B) 23.9
 LDTP04652  Eukaryotic translation initiation factor 5 (EIF5) 23.9
 LDTP12468  Diablo IAP-binding mitochondrial protein (DIABLO) 23.8
 LDTP02297  Vimentin (VIM) 23.8
 LDTP04558  Arfaptin-1 (ARFIP1) 23.4
 LDTP13987  Hepatoma-derived growth factor-related protein 3 (HDGFL3) 23.4
 LDTP03775  RNA-binding protein FUS (FUS) 23.3
 LDTP04668  Microfibrillar-associated protein 1 (MFAP1) 22.8
 LDTP10251  Protein Spindly (SPDL1) 22.3
 LDTP00880  A-kinase anchor protein 8 (AKAP8) 21.9
 LDTP01359  Dynactin subunit 3 (DCTN3) 21.9
 LDTP07891  Inhibitor of nuclear factor kappa-B kinase-interacting protein (IKBIP) 21.9
 LDTP09881  TATA-binding protein-associated factor 2N (TAF15) 21.9
 LDTP06298  IQ calmodulin-binding motif-containing protein 1 (IQCB1) 21.6
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) 21.3
 LDTP06548  Large ribosomal subunit protein uL23m (MRPL23) 20.8
 LDTP05375  Nucleobindin-1 (NUCB1) 20.8
 LDTP10184  HAUS augmin-like complex subunit 1 (HAUS1) 20.5
 LDTP04714  Heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2) 20.5
 LDTP16192  Mitochondrial fission process protein 1 (MTFP1) 20.1
 LDTP01361  DnaJ homolog subfamily C member 8 (DNAJC8) 20.0
 LDTP03615  Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) 20.0
 LDTP07368  Tetratricopeptide repeat protein 19, mitochondrial (TTC19) 20.0
 LDTP16730  Rab GTPase-activating protein 1-like, isoform 10 (RABGAP1L) 19.7
 LDTP04595  Activated RNA polymerase II transcriptional coactivator p15 (SUB1) 19.2
 LDTP02825  Histone H2AX (H2AX) 18.9
 LDTP16249  Protein angel homolog 1 (ANGEL1) 18.9
 LDTP16080  Protein FAM114A2 (FAM114A2) 18.9
 LDTP13591  A-kinase anchor protein 8-like (AKAP8L) 18.8
 LDTP08760  Cell cycle and apoptosis regulator protein 2 (CCAR2) 18.8
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 18.5
 LDTP11978  HAUS augmin-like complex subunit 4 (HAUS4) 18.5
 LDTP00573  Prefoldin subunit 6 (PFDN6) 18.5
 LDTP01075  Protein CutA (CUTA) 18.5
 LDTP04483  Hepatoma-derived growth factor (HDGF) 18.4
 LDTP00500  Heterogeneous nuclear ribonucleoprotein D-like (HNRNPDL) 18.3
 LDTP03182  Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1) 18.3
 LDTP11076  Apolipoprotein L2 (APOL2) 18.1
 LDTP10962  Heterogeneous nuclear ribonucleoprotein A/B (HNRNPAB) 18.1
 LDTP03065  Lamin-B1 (LMNB1) 18.1
 LDTP00199  HCLS1-associated protein X-1 (HAX1) 18.0
 LDTP08761  NADH dehydrogenase 1 alpha subcomplex assembly factor 2 (NDUFAF2) 18.0
 LDTP13630  Neudesin (NENF) 18.0
 LDTP18547  Protein CDV3 homolog (CDV3) 17.9
 LDTP01582  Pre-mRNA-splicing factor SLU7 (SLU7) 17.8
 LDTP11930  Oxysterol-binding protein-related protein 3 (OSBPL3) 17.6
 LDTP05036  Transformer-2 protein homolog beta (TRA2B) 17.6
 LDTP04979  U6 snRNA-associated Sm-like protein LSm3 (LSM3) 17.6
 LDTP04290  YLP motif-containing protein 1 (YLPM1) 17.6
 LDTP12285  Charged multivesicular body protein 1a (CHMP1A) 17.5
 LDTP02181  Neurofilament medium polypeptide (NEFM) 17.5
 LDTP04684  Nucleosome assembly protein 1-like 1 (NAP1L1) 17.1
 LDTP10255  Protein Hook homolog 2 (HOOK2) 17.1
 LDTP06587  Survival motor neuron protein (SMN1; SMN2) 17.1
 LDTP07655  Pre-mRNA 3'-end-processing factor FIP1 (FIP1L1) 17.0
 LDTP18494  Tropomodulin-3 (TMOD3) 17.0

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587