Details of the Target

General Information of Target

Target ID LDTP02175
Target Name Epoxide hydrolase 1 (EPHX1)
Gene Name EPHX1
Gene ID 2052
Synonyms
EPHX; EPOX; Epoxide hydrolase 1; EC 3.3.2.9; Epoxide hydratase; Microsomal epoxide hydrolase; mEH
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MWLEILLTSVLGFAIYWFISRDKEETLPLEDGWWGPGTRSAAREDDSIRPFKVETSDEEI
HDLHQRIDKFRFTPPLEDSCFHYGFNSNYLKKVISYWRNEFDWKKQVEILNRYPHFKTKI
EGLDIHFIHVKPPQLPAGHTPKPLLMVHGWPGSFYEFYKIIPLLTDPKNHGLSDEHVFEV
ICPSIPGYGFSEASSKKGFNSVATARIFYKLMLRLGFQEFYIQGGDWGSLICTNMAQLVP
SHVKGLHLNMALVLSNFSTLTLLLGQRFGRFLGLTERDVELLYPVKEKVFYSLMRESGYM
HIQCTKPDTVGSALNDSPVGLAAYILEKFSTWTNTEFRYLEDGGLERKFSLDDLLTNVML
YWTTGTIISSQRFYKENLGQGWMTQKHERMKVYVPTGFSAFPFELLHTPEKWVRFKYPKL
ISYSYMVRGGHFAAFEEPELLAQDIRKFLSVLERQ
Target Bioclass
Enzyme
Family
Peptidase S33 family
Subcellular location
Microsome membrane
Function
Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Plays a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids. Metabolizes the abundant endocannabinoid 2-arachidonoylglycerol (2-AG) to free arachidonic acid (AA) and glycerol. Binds 20(S)-hydroxycholesterol (20(S)-OHC).
Uniprot ID
P07099
Ensemble ID
ENST00000272167.10
HGNC ID
HGNC:3401
ChEMBL ID
CHEMBL1968

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 27 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
P1
 Probe Info  		10.00  LDD0452  [1]
FBPP2
 Probe Info  		2.82  LDD0318  [2]
W1
 Probe Info  		12.57  LDD0235  [3]
YN-1
 Probe Info  		100.00  LDD0444  [4]
YN-4
 Probe Info  		100.00  LDD0445  [4]
AZ-9
 Probe Info  		E336(0.91)  LDD2208  [5]
ONAyne
 Probe Info  		K286(10.00)  LDD0275  [6]
Probe 1
 Probe Info  		Y339(10.63)  LDD3495  [7]
Dasatinib-CA-4PAP
 Probe Info  		10.57  LDD0270  [8]
DBIA
 Probe Info  		C80(1.02)  LDD3312  [9]
P21
 Probe Info  		1.26  LDD0408  [10]
BTD
 Probe Info  		C80(0.70)  LDD2117  [11]
D5yne
 Probe Info  		2.56  LDD0055  [12]
Jackson_1
 Probe Info  		2.37  LDD0120  [13]
AHL-Pu-1
 Probe Info  		C182(7.81)  LDD0169  [14]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [15]
IA-alkyne
 Probe Info  		C304(0.00); C80(0.00); C182(0.00); C232(0.00)  LDD0162  [16]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [15]
IPM
 Probe Info  		N.A.  LDD0025  [17]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [17]
SF
 Probe Info  		N.A.  LDD0028  [18]
STPyne
 Probe Info  		N.A.  LDD0009  [19]
TFBX
 Probe Info  		N.A.  LDD0148  [17]
Acrolein
 Probe Info  		C182(0.00); H64(0.00); H61(0.00); H431(0.00)  LDD0217  [20]
Crotonaldehyde
 Probe Info  		H64(0.00); H61(0.00)  LDD0219  [20]
Methacrolein
 Probe Info  		N.A.  LDD0218  [20]
HHS-482
 Probe Info  		Y339(0.20)  LDD2239  [21]
PAL-AfBPP Probe
Click To Hide/Show 156 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
PARPYnD
 Probe Info  		3.48  LDD0374  [22]
C004
 Probe Info  		7.57  LDD1714  [23]
C006
 Probe Info  		15.03  LDD1715  [23]
C007
 Probe Info  		11.55  LDD1716  [23]
C017
 Probe Info  		6.68  LDD1725  [23]
C022
 Probe Info  		6.73  LDD1728  [23]
C024
 Probe Info  		5.90  LDD1730  [23]
C027
 Probe Info  		10.27  LDD1733  [23]
C028
 Probe Info  		15.89  LDD1734  [23]
C039
 Probe Info  		5.86  LDD1739  [23]
C040
 Probe Info  		7.36  LDD1740  [23]
C041
 Probe Info  		9.06  LDD1741  [23]
C042
 Probe Info  		5.46  LDD1742  [23]
C044
 Probe Info  		6.15  LDD1743  [23]
C049
 Probe Info  		7.46  LDD1747  [23]
C055
 Probe Info  		20.97  LDD1752  [23]
C056
 Probe Info  		24.59  LDD1753  [23]
C060
 Probe Info  		12.04  LDD1757  [23]
C070
 Probe Info  		17.15  LDD1766  [23]
C072
 Probe Info  		14.93  LDD1768  [23]
C082
 Probe Info  		18.77  LDD1774  [23]
C083
 Probe Info  		5.66  LDD1775  [23]
C085
 Probe Info  		6.11  LDD1777  [23]
C089
 Probe Info  		7.36  LDD1781  [23]
C091
 Probe Info  		10.48  LDD1782  [23]
C092
 Probe Info  		17.88  LDD1783  [23]
C094
 Probe Info  		28.44  LDD1785  [23]
C095
 Probe Info  		7.89  LDD1786  [23]
C100
 Probe Info  		5.28  LDD1789  [23]
C108
 Probe Info  		13.74  LDD1795  [23]
C112
 Probe Info  		22.32  LDD1799  [23]
C119
 Probe Info  		5.35  LDD1805  [23]
C130
 Probe Info  		18.90  LDD1812  [23]
C131
 Probe Info  		15.56  LDD1813  [23]
C139
 Probe Info  		29.65  LDD1821  [23]
C141
 Probe Info  		10.63  LDD1823  [23]
C142
 Probe Info  		8.51  LDD1824  [23]
C143
 Probe Info  		15.78  LDD1825  [23]
C145
 Probe Info  		28.64  LDD1827  [23]
C147
 Probe Info  		11.79  LDD1829  [23]
C153
 Probe Info  		23.10  LDD1834  [23]
C156
 Probe Info  		28.05  LDD1836  [23]
C158
 Probe Info  		9.58  LDD1838  [23]
C159
 Probe Info  		12.47  LDD1839  [23]
C160
 Probe Info  		19.70  LDD1840  [23]
C163
 Probe Info  		9.71  LDD1843  [23]
C165
 Probe Info  		33.82  LDD1845  [23]
C166
 Probe Info  		10.34  LDD1846  [23]
C173
 Probe Info  		17.39  LDD1853  [23]
C174
 Probe Info  		16.22  LDD1854  [23]
C177
 Probe Info  		15.78  LDD1856  [23]
C183
 Probe Info  		7.67  LDD1861  [23]
C185
 Probe Info  		7.46  LDD1863  [23]
C187
 Probe Info  		23.43  LDD1865  [23]
C189
 Probe Info  		5.03  LDD1866  [23]
C191
 Probe Info  		10.20  LDD1868  [23]
C194
 Probe Info  		31.78  LDD1870  [23]
C198
 Probe Info  		15.03  LDD1874  [23]
C199
 Probe Info  		7.01  LDD1875  [23]
C203
 Probe Info  		9.85  LDD1878  [23]
C205
 Probe Info  		11.08  LDD1880  [23]
C206
 Probe Info  		47.50  LDD1881  [23]
C207
 Probe Info  		24.25  LDD1882  [23]
C212
 Probe Info  		7.31  LDD1886  [23]
C220
 Probe Info  		14.22  LDD1894  [23]
C222
 Probe Info  		7.73  LDD1896  [23]
C225
 Probe Info  		5.58  LDD1898  [23]
C226
 Probe Info  		16.45  LDD1899  [23]
C232
 Probe Info  		37.01  LDD1905  [23]
C234
 Probe Info  		19.97  LDD1907  [23]
C235
 Probe Info  		28.25  LDD1908  [23]
C238
 Probe Info  		41.93  LDD1911  [23]
C239
 Probe Info  		6.41  LDD1912  [23]
C246
 Probe Info  		25.63  LDD1919  [23]
C249
 Probe Info  		11.96  LDD1922  [23]
C256
 Probe Info  		5.24  LDD1929  [23]
C257
 Probe Info  		5.50  LDD1930  [23]
C265
 Probe Info  		14.12  LDD1936  [23]
C269
 Probe Info  		20.97  LDD1939  [23]
C271
 Probe Info  		5.21  LDD1941  [23]
C272
 Probe Info  		7.31  LDD1942  [23]
C273
 Probe Info  		5.74  LDD1943  [23]
C277
 Probe Info  		9.38  LDD1947  [23]
C279
 Probe Info  		6.50  LDD1949  [23]
C280
 Probe Info  		20.68  LDD1950  [23]
C284
 Probe Info  		20.97  LDD1954  [23]
C286
 Probe Info  		6.50  LDD1956  [23]
C287
 Probe Info  		11.79  LDD1957  [23]
C290
 Probe Info  		6.59  LDD1960  [23]
C292
 Probe Info  		4.92  LDD1962  [23]
C293
 Probe Info  		22.47  LDD1963  [23]
C296
 Probe Info  		14.62  LDD1966  [23]
C303
 Probe Info  		15.78  LDD1972  [23]
C304
 Probe Info  		8.34  LDD1973  [23]
C305
 Probe Info  		26.54  LDD1974  [23]
C311
 Probe Info  		17.15  LDD1978  [23]
C314
 Probe Info  		13.64  LDD1981  [23]
C322
 Probe Info  		10.41  LDD1988  [23]
C326
 Probe Info  		18.51  LDD1990  [23]
C327
 Probe Info  		7.89  LDD1991  [23]
C329
 Probe Info  		5.86  LDD1993  [23]
C333
 Probe Info  		18.25  LDD1996  [23]
C338
 Probe Info  		10.93  LDD2001  [23]
C339
 Probe Info  		18.51  LDD2002  [23]
C347
 Probe Info  		5.43  LDD2008  [23]
C349
 Probe Info  		13.55  LDD2010  [23]
C351
 Probe Info  		16.22  LDD2012  [23]
C354
 Probe Info  		10.93  LDD2015  [23]
C355
 Probe Info  		25.63  LDD2016  [23]
C357
 Probe Info  		19.97  LDD2018  [23]
C361
 Probe Info  		37.79  LDD2022  [23]
C362
 Probe Info  		55.72  LDD2023  [23]
C363
 Probe Info  		30.27  LDD2024  [23]
C364
 Probe Info  		17.27  LDD2025  [23]
C366
 Probe Info  		5.86  LDD2027  [23]
C367
 Probe Info  		11.00  LDD2028  [23]
C373
 Probe Info  		9.58  LDD2033  [23]
C374
 Probe Info  		6.63  LDD2034  [23]
C378
 Probe Info  		10.93  LDD2037  [23]
C382
 Probe Info  		10.41  LDD2041  [23]
C383
 Probe Info  		12.64  LDD2042  [23]
C385
 Probe Info  		4.99  LDD2044  [23]
C386
 Probe Info  		12.64  LDD2045  [23]
C387
 Probe Info  		5.43  LDD2046  [23]
C390
 Probe Info  		24.76  LDD2049  [23]
C391
 Probe Info  		27.10  LDD2050  [23]
C396
 Probe Info  		11.39  LDD2055  [23]
C397
 Probe Info  		12.82  LDD2056  [23]
C399
 Probe Info  		9.00  LDD2058  [23]
C407
 Probe Info  		21.41  LDD2064  [23]
C408
 Probe Info  		7.57  LDD2065  [23]
C409
 Probe Info  		8.22  LDD2066  [23]
C420
 Probe Info  		19.70  LDD2075  [23]
C422
 Probe Info  		15.45  LDD2077  [23]
C424
 Probe Info  		7.46  LDD2079  [23]
C426
 Probe Info  		60.13  LDD2081  [23]
C428
 Probe Info  		19.56  LDD2083  [23]
C429
 Probe Info  		25.63  LDD2084  [23]
C430
 Probe Info  		17.75  LDD2085  [23]
C432
 Probe Info  		15.89  LDD2087  [23]
C433
 Probe Info  		12.82  LDD2088  [23]
FFF probe11
 Probe Info  		14.91  LDD0471  [24]
FFF probe13
 Probe Info  		19.31  LDD0475  [24]
FFF probe14
 Probe Info  		20.00  LDD0477  [24]
FFF probe15
 Probe Info  		16.57  LDD0490  [24]
FFF probe2
 Probe Info  		15.75  LDD0463  [24]
FFF probe3
 Probe Info  		20.00  LDD0464  [24]
FFF probe4
 Probe Info  		19.07  LDD0466  [24]
FFF probe6
 Probe Info  		20.00  LDD0467  [24]
FFF probe7
 Probe Info  		13.13  LDD0483  [24]
FFF probe9
 Probe Info  		17.23  LDD0470  [24]
JN0003
 Probe Info  		20.00  LDD0484  [24]
VE-P
 Probe Info  		N.A.  LDD0396  [25]
A-DA
 Probe Info  		2.45  LDD0143  [26]
LD-F
 Probe Info  		P318(0.00); T305(0.00); H301(0.00); Y299(0.00)  LDD0015  [27]
OEA-DA
 Probe Info  		4.72  LDD0046  [28]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C80(0.70)  LDD2117  [11]
 LDCM0025  4SU-RNA DM93 C304(3.78)  LDD0170  [14]
 LDCM0026  4SU-RNA+native RNA HEK-293T C182(7.81)  LDD0169  [14]
 LDCM0214  AC1 HEK-293T C80(0.62); C232(1.20)  LDD1507  [29]
 LDCM0215  AC10 HEK-293T C80(0.94); C304(0.78)  LDD1508  [29]
 LDCM0226  AC11 HEK-293T C80(0.85)  LDD1509  [29]
 LDCM0237  AC12 HEK-293T C80(0.57); C232(0.90); C304(1.03)  LDD1510  [29]
 LDCM0259  AC14 HEK-293T C80(0.87)  LDD1512  [29]
 LDCM0270  AC15 HEK-293T C80(0.88)  LDD1513  [29]
 LDCM0276  AC17 HEK-293T C80(0.77); C232(1.13)  LDD1515  [29]
 LDCM0277  AC18 HEK-293T C80(1.02); C304(0.95)  LDD1516  [29]
 LDCM0278  AC19 HEK-293T C80(0.67)  LDD1517  [29]
 LDCM0279  AC2 HEK-293T C80(1.02); C304(0.80)  LDD1518  [29]
 LDCM0280  AC20 HEK-293T C80(1.09); C232(1.06); C304(0.98)  LDD1519  [29]
 LDCM0281  AC21 HEK-293T C80(0.85); C304(1.42)  LDD1520  [29]
 LDCM0282  AC22 HEK-293T C80(0.94)  LDD1521  [29]
 LDCM0283  AC23 HEK-293T C80(1.14)  LDD1522  [29]
 LDCM0284  AC24 HEK-293T C80(1.72)  LDD1523  [29]
 LDCM0285  AC25 HEK-293T C80(0.69); C232(1.07)  LDD1524  [29]
 LDCM0286  AC26 HEK-293T C80(0.94); C304(0.83)  LDD1525  [29]
 LDCM0287  AC27 HEK-293T C80(0.78)  LDD1526  [29]
 LDCM0288  AC28 HEK-293T C80(0.89); C232(1.18); C304(0.87)  LDD1527  [29]
 LDCM0289  AC29 HEK-293T C80(0.95); C304(0.87)  LDD1528  [29]
 LDCM0290  AC3 HEK-293T C80(0.91)  LDD1529  [29]
 LDCM0291  AC30 HEK-293T C80(0.96)  LDD1530  [29]
 LDCM0292  AC31 HEK-293T C80(1.10)  LDD1531  [29]
 LDCM0293  AC32 HEK-293T C80(1.01)  LDD1532  [29]
 LDCM0294  AC33 HEK-293T C80(0.76); C232(1.15)  LDD1533  [29]
 LDCM0295  AC34 HEK-293T C80(1.07); C304(0.84)  LDD1534  [29]
 LDCM0296  AC35 HEK-293T C80(0.83)  LDD1535  [29]
 LDCM0297  AC36 HEK-293T C80(0.57); C232(1.00); C304(1.08)  LDD1536  [29]
 LDCM0298  AC37 HEK-293T C80(1.05); C304(1.03)  LDD1537  [29]
 LDCM0299  AC38 HEK-293T C80(1.00)  LDD1538  [29]
 LDCM0300  AC39 HEK-293T C80(0.93)  LDD1539  [29]
 LDCM0301  AC4 HEK-293T C80(0.58); C232(1.04); C304(1.15)  LDD1540  [29]
 LDCM0302  AC40 HEK-293T C80(0.96)  LDD1541  [29]
 LDCM0303  AC41 HEK-293T C80(0.82); C232(1.11)  LDD1542  [29]
 LDCM0304  AC42 HEK-293T C80(1.00); C304(0.71)  LDD1543  [29]
 LDCM0305  AC43 HEK-293T C80(0.75)  LDD1544  [29]
 LDCM0306  AC44 HEK-293T C80(0.87); C232(0.95); C304(0.87)  LDD1545  [29]
 LDCM0307  AC45 HEK-293T C80(0.90); C304(1.09)  LDD1546  [29]
 LDCM0308  AC46 HEK-293T C80(0.97)  LDD1547  [29]
 LDCM0309  AC47 HEK-293T C80(0.93)  LDD1548  [29]
 LDCM0310  AC48 HEK-293T C80(1.20)  LDD1549  [29]
 LDCM0311  AC49 HEK-293T C80(0.75); C232(1.19)  LDD1550  [29]
 LDCM0312  AC5 HEK-293T C80(1.02); C304(0.89)  LDD1551  [29]
 LDCM0313  AC50 HEK-293T C80(0.98); C304(0.61)  LDD1552  [29]
 LDCM0314  AC51 HEK-293T C80(0.98)  LDD1553  [29]
 LDCM0315  AC52 HEK-293T C80(0.71); C232(0.86); C304(0.79)  LDD1554  [29]
 LDCM0316  AC53 HEK-293T C80(0.95); C304(0.85)  LDD1555  [29]
 LDCM0317  AC54 HEK-293T C80(0.95)  LDD1556  [29]
 LDCM0318  AC55 HEK-293T C80(0.85)  LDD1557  [29]
 LDCM0319  AC56 HEK-293T C80(1.15)  LDD1558  [29]
 LDCM0320  AC57 HEK-293T C80(0.78); C232(1.28)  LDD1559  [29]
 LDCM0321  AC58 HEK-293T C80(0.74); C304(0.97)  LDD1560  [29]
 LDCM0322  AC59 HEK-293T C80(0.81)  LDD1561  [29]
 LDCM0323  AC6 HEK-293T C80(0.92)  LDD1562  [29]
 LDCM0324  AC60 HEK-293T C80(0.74); C232(1.06); C304(1.21)  LDD1563  [29]
 LDCM0325  AC61 HEK-293T C80(0.90); C304(0.89)  LDD1564  [29]
 LDCM0326  AC62 HEK-293T C80(0.88)  LDD1565  [29]
 LDCM0327  AC63 HEK-293T C80(0.81)  LDD1566  [29]
 LDCM0328  AC64 HEK-293T C80(1.04)  LDD1567  [29]
 LDCM0334  AC7 HEK-293T C80(0.98)  LDD1568  [29]
 LDCM0345  AC8 HEK-293T C80(0.83)  LDD1569  [29]
 LDCM0248  AKOS034007472 HEK-293T C80(0.95); C304(0.96)  LDD1511  [29]
 LDCM0356  AKOS034007680 HEK-293T C80(0.71); C232(0.93)  LDD1570  [29]
 LDCM0275  AKOS034007705 HEK-293T C80(0.83)  LDD1514  [29]
 LDCM0083  Avasimibe A-549 2.45  LDD0143  [26]
 LDCM0147  AZ0108 MDA-MB-468 1.83  LDD0376  [22]
 LDCM0108  Chloroacetamide HeLa H64(0.00); C182(0.00); H61(0.00); C80(0.00)  LDD0222  [20]
 LDCM0071  Cisar_cp14 MDA-MB-231 4.88  LDD0121  [13]
 LDCM0070  Cisar_cp37 MDA-MB-231 2.37  LDD0120  [13]
 LDCM0367  CL1 HEK-293T C80(1.04); C232(2.11)  LDD1571  [29]
 LDCM0368  CL10 HEK-293T C80(0.95)  LDD1572  [29]
 LDCM0369  CL100 HEK-293T C80(0.76); C232(0.97)  LDD1573  [29]
 LDCM0370  CL101 HEK-293T C80(0.88); C232(1.28)  LDD1574  [29]
 LDCM0371  CL102 HEK-293T C232(1.04)  LDD1575  [29]
 LDCM0372  CL103 HEK-293T C80(0.71); C232(0.85)  LDD1576  [29]
 LDCM0373  CL104 HEK-293T C80(0.77); C232(0.95)  LDD1577  [29]
 LDCM0374  CL105 HEK-293T C80(1.06); C232(1.75)  LDD1578  [29]
 LDCM0375  CL106 HEK-293T C232(0.92)  LDD1579  [29]
 LDCM0376  CL107 HEK-293T C80(0.74); C232(0.88)  LDD1580  [29]
 LDCM0377  CL108 HEK-293T C80(0.90); C232(0.92)  LDD1581  [29]
 LDCM0378  CL109 HEK-293T C80(1.02); C232(1.53)  LDD1582  [29]
 LDCM0379  CL11 HEK-293T C80(1.19)  LDD1583  [29]
 LDCM0380  CL110 HEK-293T C232(0.90)  LDD1584  [29]
 LDCM0381  CL111 HEK-293T C80(0.69); C232(0.88)  LDD1585  [29]
 LDCM0382  CL112 HEK-293T C80(0.77); C232(0.96)  LDD1586  [29]
 LDCM0383  CL113 HEK-293T C80(0.95); C232(1.38)  LDD1587  [29]
 LDCM0384  CL114 HEK-293T C232(0.78)  LDD1588  [29]
 LDCM0385  CL115 HEK-293T C80(0.72); C232(1.03)  LDD1589  [29]
 LDCM0386  CL116 HEK-293T C80(0.94); C232(0.82)  LDD1590  [29]
 LDCM0387  CL117 HEK-293T C80(0.87); C232(1.32)  LDD1591  [29]
 LDCM0388  CL118 HEK-293T C232(0.96)  LDD1592  [29]
 LDCM0389  CL119 HEK-293T C80(0.73); C232(1.06)  LDD1593  [29]
 LDCM0390  CL12 HEK-293T C80(0.76)  LDD1594  [29]
 LDCM0391  CL120 HEK-293T C80(0.63); C232(0.90)  LDD1595  [29]
 LDCM0392  CL121 HEK-293T C80(0.94); C232(1.55)  LDD1596  [29]
 LDCM0393  CL122 HEK-293T C232(1.03)  LDD1597  [29]
 LDCM0394  CL123 HEK-293T C80(0.65); C232(1.00)  LDD1598  [29]
 LDCM0395  CL124 HEK-293T C80(0.74); C232(0.84)  LDD1599  [29]
 LDCM0396  CL125 HEK-293T C80(0.79); C232(1.51)  LDD1600  [29]
 LDCM0397  CL126 HEK-293T C232(1.03)  LDD1601  [29]
 LDCM0398  CL127 HEK-293T C80(0.72); C232(0.89)  LDD1602  [29]
 LDCM0399  CL128 HEK-293T C80(0.60); C232(0.94)  LDD1603  [29]
 LDCM0400  CL13 HEK-293T C80(0.82); C232(1.37)  LDD1604  [29]
 LDCM0401  CL14 HEK-293T C232(0.88)  LDD1605  [29]
 LDCM0402  CL15 HEK-293T C80(0.68); C232(0.81)  LDD1606  [29]
 LDCM0403  CL16 HEK-293T C80(0.91); C232(0.99)  LDD1607  [29]
 LDCM0404  CL17 HEK-293T C80(0.85); C232(1.06)  LDD1608  [29]
 LDCM0405  CL18 HEK-293T C80(0.88); C304(0.74)  LDD1609  [29]
 LDCM0406  CL19 HEK-293T C80(0.72)  LDD1610  [29]
 LDCM0407  CL2 HEK-293T C232(0.89)  LDD1611  [29]
 LDCM0408  CL20 HEK-293T C80(0.59); C232(1.34); C304(1.00)  LDD1612  [29]
 LDCM0409  CL21 HEK-293T C80(0.81); C304(0.89)  LDD1613  [29]
 LDCM0410  CL22 HEK-293T C80(1.09)  LDD1614  [29]
 LDCM0411  CL23 HEK-293T C80(0.89)  LDD1615  [29]
 LDCM0412  CL24 HEK-293T C80(1.18)  LDD1616  [29]
 LDCM0413  CL25 HEK-293T C80(0.76); C232(1.21)  LDD1617  [29]
 LDCM0414  CL26 HEK-293T C232(0.93)  LDD1618  [29]
 LDCM0415  CL27 HEK-293T C80(0.85); C232(1.00)  LDD1619  [29]
 LDCM0416  CL28 HEK-293T C80(0.63); C232(0.78)  LDD1620  [29]
 LDCM0417  CL29 HEK-293T C80(0.68); C232(1.13)  LDD1621  [29]
 LDCM0418  CL3 HEK-293T C80(0.81); C232(0.99)  LDD1622  [29]
 LDCM0419  CL30 HEK-293T C80(0.96); C304(0.66)  LDD1623  [29]
 LDCM0420  CL31 HEK-293T C80(0.85)  LDD1624  [29]
 LDCM0421  CL32 HEK-293T C80(0.78); C232(0.93); C304(1.04)  LDD1625  [29]
 LDCM0422  CL33 HEK-293T C80(0.76); C304(1.33)  LDD1626  [29]
 LDCM0423  CL34 HEK-293T C80(0.91)  LDD1627  [29]
 LDCM0424  CL35 HEK-293T C80(0.96)  LDD1628  [29]
 LDCM0425  CL36 HEK-293T C80(1.39)  LDD1629  [29]
 LDCM0426  CL37 HEK-293T C80(1.00); C232(1.08)  LDD1630  [29]
 LDCM0428  CL39 HEK-293T C80(0.78); C232(0.83)  LDD1632  [29]
 LDCM0429  CL4 HEK-293T C80(0.85); C232(0.93)  LDD1633  [29]
 LDCM0430  CL40 HEK-293T C80(0.92); C232(1.21)  LDD1634  [29]
 LDCM0431  CL41 HEK-293T C80(0.58); C232(1.16)  LDD1635  [29]
 LDCM0432  CL42 HEK-293T C80(0.83); C304(0.78)  LDD1636  [29]
 LDCM0433  CL43 HEK-293T C80(0.87)  LDD1637  [29]
 LDCM0434  CL44 HEK-293T C80(0.96); C232(1.01); C304(0.87)  LDD1638  [29]
 LDCM0435  CL45 HEK-293T C80(0.80); C304(1.04)  LDD1639  [29]
 LDCM0436  CL46 HEK-293T C80(0.91)  LDD1640  [29]
 LDCM0437  CL47 HEK-293T C80(0.91)  LDD1641  [29]
 LDCM0438  CL48 HEK-293T C80(1.18)  LDD1642  [29]
 LDCM0439  CL49 HEK-293T C80(0.88); C232(1.30)  LDD1643  [29]
 LDCM0440  CL5 HEK-293T C80(0.70); C232(1.21)  LDD1644  [29]
 LDCM0441  CL50 HEK-293T C232(0.72)  LDD1645  [29]
 LDCM0443  CL52 HEK-293T C80(0.66); C232(0.77)  LDD1646  [29]
 LDCM0444  CL53 HEK-293T C80(0.66); C232(1.09)  LDD1647  [29]
 LDCM0445  CL54 HEK-293T C80(0.82); C304(0.69)  LDD1648  [29]
 LDCM0446  CL55 HEK-293T C80(0.85)  LDD1649  [29]
 LDCM0447  CL56 HEK-293T C80(0.65); C232(0.98); C304(0.81)  LDD1650  [29]
 LDCM0448  CL57 HEK-293T C80(0.83); C304(0.85)  LDD1651  [29]
 LDCM0449  CL58 HEK-293T C80(0.93)  LDD1652  [29]
 LDCM0450  CL59 HEK-293T C80(0.89)  LDD1653  [29]
 LDCM0451  CL6 HEK-293T C80(0.84); C304(0.85)  LDD1654  [29]
 LDCM0452  CL60 HEK-293T C80(1.01)  LDD1655  [29]
 LDCM0453  CL61 HEK-293T C80(0.99); C232(2.02)  LDD1656  [29]
 LDCM0454  CL62 HEK-293T C232(1.15)  LDD1657  [29]
 LDCM0455  CL63 HEK-293T C80(0.52); C232(0.90)  LDD1658  [29]
 LDCM0456  CL64 HEK-293T C80(0.93); C232(0.90)  LDD1659  [29]
 LDCM0457  CL65 HEK-293T C80(0.76); C232(1.20)  LDD1660  [29]
 LDCM0458  CL66 HEK-293T C80(0.83); C304(0.76)  LDD1661  [29]
 LDCM0459  CL67 HEK-293T C80(0.88)  LDD1662  [29]
 LDCM0460  CL68 HEK-293T C80(0.63); C232(0.82); C304(0.85)  LDD1663  [29]
 LDCM0461  CL69 HEK-293T C80(0.83); C304(0.63)  LDD1664  [29]
 LDCM0462  CL7 HEK-293T C80(0.80)  LDD1665  [29]
 LDCM0463  CL70 HEK-293T C80(0.91)  LDD1666  [29]
 LDCM0464  CL71 HEK-293T C80(0.93)  LDD1667  [29]
 LDCM0465  CL72 HEK-293T C80(0.86)  LDD1668  [29]
 LDCM0466  CL73 HEK-293T C80(1.01); C232(1.35)  LDD1669  [29]
 LDCM0467  CL74 HEK-293T C232(1.26)  LDD1670  [29]
 LDCM0469  CL76 HEK-293T C80(0.86); C232(0.97)  LDD1672  [29]
 LDCM0470  CL77 HEK-293T C80(0.52); C232(0.98)  LDD1673  [29]
 LDCM0471  CL78 HEK-293T C80(0.84); C304(0.89)  LDD1674  [29]
 LDCM0472  CL79 HEK-293T C80(0.88)  LDD1675  [29]
 LDCM0473  CL8 HEK-293T C80(0.45); C232(1.05); C304(0.89)  LDD1676  [29]
 LDCM0474  CL80 HEK-293T C80(0.55); C232(1.01); C304(0.93)  LDD1677  [29]
 LDCM0475  CL81 HEK-293T C80(0.86); C304(0.71)  LDD1678  [29]
 LDCM0476  CL82 HEK-293T C80(0.89)  LDD1679  [29]
 LDCM0477  CL83 HEK-293T C80(0.85)  LDD1680  [29]
 LDCM0478  CL84 HEK-293T C80(0.95)  LDD1681  [29]
 LDCM0479  CL85 HEK-293T C80(0.91); C232(1.06)  LDD1682  [29]
 LDCM0480  CL86 HEK-293T C232(1.02)  LDD1683  [29]
 LDCM0481  CL87 HEK-293T C80(0.62); C232(0.81)  LDD1684  [29]
 LDCM0482  CL88 HEK-293T C80(0.82); C232(1.04)  LDD1685  [29]
 LDCM0483  CL89 HEK-293T C80(0.56); C232(1.15)  LDD1686  [29]
 LDCM0484  CL9 HEK-293T C80(1.02); C304(0.98)  LDD1687  [29]
 LDCM0485  CL90 HEK-293T C80(0.67); C304(0.89)  LDD1688  [29]
 LDCM0486  CL91 HEK-293T C80(0.73)  LDD1689  [29]
 LDCM0487  CL92 HEK-293T C80(0.56); C232(0.94); C304(0.98)  LDD1690  [29]
 LDCM0488  CL93 HEK-293T C80(0.79); C304(0.81)  LDD1691  [29]
 LDCM0489  CL94 HEK-293T C80(0.93)  LDD1692  [29]
 LDCM0490  CL95 HEK-293T C80(0.69)  LDD1693  [29]
 LDCM0491  CL96 HEK-293T C80(0.71)  LDD1694  [29]
 LDCM0492  CL97 HEK-293T C80(0.89); C232(1.40)  LDD1695  [29]
 LDCM0493  CL98 HEK-293T C232(0.89)  LDD1696  [29]
 LDCM0494  CL99 HEK-293T C80(0.83); C232(0.90)  LDD1697  [29]
 LDCM0189  Compound 16 HEK-293T 7.38  LDD0492  [24]
 LDCM0185  Compound 17 HEK-293T 12.12  LDD0504  [24]
 LDCM0184  Compound 20 HEK-293T 6.31  LDD0503  [24]
 LDCM0191  Compound 21 HEK-293T 6.21  LDD0508  [24]
 LDCM0186  Compound 31 HEK-293T 6.45  LDD0506  [24]
 LDCM0187  Compound 32 HEK-293T 48.78  LDD0507  [24]
 LDCM0190  Compound 34 HEK-293T 7.49  LDD0497  [24]
 LDCM0192  Compound 35 HEK-293T 5.22  LDD0491  [24]
 LDCM0193  Compound 36 HEK-293T 3.90  LDD0494  [24]
 LDCM0194  Compound 37 HEK-293T 4.18  LDD0498  [24]
 LDCM0195  Compound 38 HEK-293T 4.87  LDD0499  [24]
 LDCM0196  Compound 39 HEK-293T 10.00  LDD0496  [24]
 LDCM0197  Compound 40 HEK-293T 12.20  LDD0495  [24]
 LDCM0183  Compound 42 HEK-293T 4.54  LDD0500  [24]
 LDCM0097  Dasatinib K562 10.57  LDD0270  [8]
 LDCM0095  DC-LC3IN-D5 HeLa 2.56  LDD0055  [12]
 LDCM0495  E2913 HEK-293T C80(0.71); C232(0.77)  LDD1698  [29]
 LDCM0468  Fragment33 HEK-293T C80(0.58); C232(0.94)  LDD1671  [29]
 LDCM0427  Fragment51 HEK-293T C232(0.92)  LDD1631  [29]
 LDCM0107  IAA HeLa H64(0.00); H431(0.00); C182(0.00); H61(0.00)  LDD0221  [20]
 LDCM0022  KB02 HEK-293T C80(1.32)  LDD1492  [29]
 LDCM0023  KB03 HEK-293T C80(1.09)  LDD1497  [29]
 LDCM0024  KB05 HMCB C80(1.02)  LDD3312  [9]
 LDCM0109  NEM HeLa H61(0.00); H64(0.00); H431(0.00)  LDD0223  [20]
 LDCM0158  P27 BxPC-3 1.26  LDD0408  [10]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Indapamide Small molecular drug DB00808
Phenytoin Small molecular drug DB00252

References

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2 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
4 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
5 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
6 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
7 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
8 Streamlined Target Deconvolution Approach Utilizing a Single Photoreactive Chloroalkane Capture Tag. ACS Chem Biol. 2021 Feb 19;16(2):404-413. doi: 10.1021/acschembio.0c00987. Epub 2021 Feb 5.
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
10 Integrated phenotypic screening and activity-based protein profiling to reveal potential therapy targets of pancreatic cancer. Chem Commun (Camb). 2019 Jan 31;55(11):1596-1599. doi: 10.1039/c8cc08753a.
11 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
12 Inhibition of Autophagy by a Small Molecule through Covalent Modification of the LC3 Protein. Angew Chem Int Ed Engl. 2021 Dec 6;60(50):26105-26114. doi: 10.1002/anie.202109464. Epub 2021 Nov 5.
Mass spectrometry data entry: PXD026874
13 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
14 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
15 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
16 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
17 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
18 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
19 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
20 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
21 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
22 Structure-Guided Design and In-Cell Target Profiling of a Cell-Active Target Engagement Probe for PARP Inhibitors. ACS Chem Biol. 2020 Feb 21;15(2):325-333. doi: 10.1021/acschembio.9b00963. Epub 2020 Feb 10.
23 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
24 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
25 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
26 A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. doi: 10.1016/j.cell.2015.05.045.
27 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652
28 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
29 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402