Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C303  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 41 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 26.7
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 18.0
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 15.8
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 13.3
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 12.0
 LDTP03417  Proteasome subunit beta type-4 (PSMB4) 11.7
 LDTP06645  Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HADH) 11.6
 LDTP04246  Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (FNTA) 11.4
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 11.1
 LDTP17785  Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial (PDPR) 11.0
 LDTP04211  Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) 10.5
 LDTP06227  Prostaglandin reductase 1 (PTGR1) 9.9
 LDTP09088  Phospholipase A2 group XV (PLA2G15) 9.6
 LDTP04689  Adenosine kinase (ADK) 8.6
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 8.5
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 7.7
 LDTP00907  Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D) 7.6
 LDTP10329  Ceramide synthase 2 (CERS2) 7.4
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 7.3
 LDTP00246  Eukaryotic translation initiation factor 3 subunit F (EIF3F) 7.2
 LDTP12253  Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM) 6.9
 LDTP13620  Lysosomal thioesterase PPT2 (PPT2) 6.5
 LDTP09799  DCN1-like protein 4 (DCUN1D4) 6.3
 LDTP13751  Exonuclease 1 (EXO1) 6.2
 LDTP01769  Dihydrofolate reductase (DHFR) 6.1
 LDTP14801  Di-N-acetylchitobiase (CTBS) 6.0
 LDTP03060  Proteasome subunit beta type-1 (PSMB1) 6.0
 LDTP01333  Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) 5.9
 LDTP02359  Heme oxygenase 1 (HMOX1) 5.5
 LDTP15484  Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) 5.5
 LDTP13154  E3 ubiquitin-protein ligase RNF14 (RNF14) 5.4
 LDTP01773  Cytochrome c oxidase subunit 2 (MT-CO2) 5.4
 LDTP15422  Prostaglandin reductase 3 (PTGR3) 5.4
 LDTP02679  Prolyl 4-hydroxylase subunit alpha-1 (P4HA1) 5.2
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 5.2
 LDTP12610  Obg-like ATPase 1 (OLA1) 5.2
 LDTP12524  L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase (AASDHPPT) 5.1
 LDTP10550  Dehydrogenase/reductase SDR family member 1 (DHRS1) 5.1
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 5.1
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 5.0
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 5.0
Transporter and channel
Click to Show/Hide to Show 20 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 16.8
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 14.5
 LDTP18153  Major facilitator superfamily domain-containing protein 3 (MFSD3) 13.0
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 9.3
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 9.0
 LDTP08881  Transmembrane protein 199 (TMEM199) 8.6
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 8.3
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 8.1
 LDTP04592  Monocarboxylate transporter 1 (SLC16A1) 7.8
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 7.5
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 7.4
 LDTP05384  Mitochondrial 2-oxoglutarate/malate carrier protein (SLC25A11) 7.3
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 7.3
 LDTP07236  Protein GPR107 (GPR107) 6.3
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 5.9
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 5.9
 LDTP17641  Solute carrier family 35 member F2 (SLC35F2) 5.8
 LDTP02215  Prosaposin (PSAP) 5.7
 LDTP06275  Lysosomal-associated transmembrane protein 4A (LAPTM4A) 5.6
 LDTP09261  Major facilitator superfamily domain-containing protein 8 (MFSD8) 4.9
Other
Click to Show/Hide to Show 18 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 22.5
 LDTP00105  Protein unc-119 homolog B (UNC119B) 15.2
 LDTP15623  Neuferricin (CYB5D2) 9.4
 LDTP08766  Vacuolar protein sorting-associated protein 52 homolog (VPS52) 7.2
 LDTP15714  Mdm2-binding protein (MTBP) 6.8
 LDTP11076  Apolipoprotein L2 (APOL2) 6.7
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 6.5
 LDTP01153  CCR4-NOT transcription complex subunit 3 (CNOT3) 6.3
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 6.3
 LDTP13606  Mammalian ependymin-related protein 1 (EPDR1) 6.3
 LDTP05160  Nucleobindin-2 (NUCB2) 6.2
 LDTP12891  Glycolipid transfer protein (GLTP) 5.9
 LDTP14172  Sorting nexin-9 (SNX9) 5.4
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 5.4
 LDTP01002  Cyclin-T1 (CCNT1) 5.3
 LDTP10452  Conserved oligomeric Golgi complex subunit 3 (COG3) 5.2
 LDTP03775  RNA-binding protein FUS (FUS) 5.1
 LDTP07368  Tetratricopeptide repeat protein 19, mitochondrial (TTC19) 5.0

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587