Details of the Target

General Information of Target

Target ID LDTP00246
Target Name Eukaryotic translation initiation factor 3 subunit F (EIF3F)
Gene Name EIF3F
Gene ID 8665
Synonyms
EIF3S5; Eukaryotic translation initiation factor 3 subunit F; eIF3f; Deubiquitinating enzyme eIF3f; EC 3.4.19.12; Eukaryotic translation initiation factor 3 subunit 5; eIF-3-epsilon; eIF3 p47
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATPAVPVSAPPATPTPVPAAAPASVPAPTPAPAAAPVPAAAPASSSDPAAAAAATAAPG
QTPASAQAPAQTPAPALPGPALPGPFPGGRVVRLHPVILASIVDSYERRNEGAARVIGTL
LGTVDKHSVEVTNCFSVPHNESEDEVAVDMEFAKNMYELHKKVSPNELILGWYATGHDIT
EHSVLIHEYYSREAPNPIHLTVDTSLQNGRMSIKAYVSTLMGVPGRTMGVMFTPLTVKYA
YYDTERIGVDLIMKTCFSPNRVIGLSSDLQQVGGASARIQDALSTVLQYAEDVLSGKVSA
DNTVGRFLMSLVNQVPKIVPDDFETMLNSNINDLLMVTYLANLTQSQIALNEKLVNL
Target Bioclass
Enzyme
Family
EIF-3 subunit F family
Subcellular location
Cytoplasm
Function
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. {|HAMAP-Rule:MF_03005}.; Deubiquitinates activated NOTCH1, promoting its nuclear import, thereby acting as a positive regulator of Notch signaling.
Uniprot ID
O00303
Ensemble ID
ENST00000533626.5
HGNC ID
HGNC:3275
ChEMBL ID
CHEMBL2062352

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 28 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.50  LDD0402  [1]
CY-1
 Probe Info  		3.01  LDD0243  [2]
CY4
 Probe Info  		100.00  LDD0244  [2]
TH211
 Probe Info  		Y157(20.00)  LDD0257  [3]
YN-1
 Probe Info  		100.00  LDD0444  [4]
STPyne
 Probe Info  		K161(10.00); K214(0.85)  LDD0277  [5]
BTD
 Probe Info  		C256(3.22)  LDD1699  [6]
Probe 1
 Probe Info  		Y239(4.81)  LDD3495  [7]
AHL-Pu-1
 Probe Info  		C256(2.61)  LDD0169  [8]
HHS-475
 Probe Info  		Y157(0.98)  LDD0264  [9]
DBIA
 Probe Info  		C256(2.41)  LDD0080  [10]
5E-2FA
 Probe Info  		N.A.  LDD2235  [11]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [12]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [12]
Lodoacetamide azide
 Probe Info  		C256(0.00); C134(0.00)  LDD0037  [12]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [13]
NAIA_4
 Probe Info  		N.A.  LDD2226  [14]
NAIA_5
 Probe Info  		N.A.  LDD2224  [14]
TFBX
 Probe Info  		N.A.  LDD0027  [13]
Compound 10
 Probe Info  		N.A.  LDD2216  [15]
IPM
 Probe Info  		N.A.  LDD0005  [16]
SF
 Probe Info  		N.A.  LDD0028  [17]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [18]
Ox-W18
 Probe Info  		N.A.  LDD2175  [19]
Acrolein
 Probe Info  		N.A.  LDD0217  [20]
Methacrolein
 Probe Info  		N.A.  LDD0218  [20]
AOyne
 Probe Info  		15.00  LDD0443  [21]
HHS-482
 Probe Info  		Y157(1.08); Y242(1.16)  LDD2239  [22]
PAL-AfBPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C296
 Probe Info  		18.38  LDD1966  [23]
C303
 Probe Info  		7.16  LDD1972  [23]
C420
 Probe Info  		14.22  LDD2075  [23]
FFF probe11
 Probe Info  		7.13  LDD0471  [24]
FFF probe13
 Probe Info  		12.96  LDD0475  [24]
FFF probe14
 Probe Info  		12.87  LDD0477  [24]
FFF probe2
 Probe Info  		14.68  LDD0463  [24]
FFF probe3
 Probe Info  		9.01  LDD0464  [24]
FFF probe6
 Probe Info  		12.77  LDD0467  [24]
STS-1
 Probe Info  		N.A.  LDD0137  [25]
STS-2
 Probe Info  		N.A.  LDD0138  [25]
VE-P
 Probe Info  		N.A.  LDD0396  [26]
Staurosporine capture compound
 Probe Info  		N.A.  LDD0083  [27]
DA-2
 Probe Info  		N.A.  LDD0070  [28]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C256(0.73)  LDD2142  [6]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C256(0.86)  LDD2112  [6]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C256(0.54)  LDD2095  [6]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C256(1.17)  LDD2117  [6]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C256(1.45)  LDD2152  [6]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C256(0.52)  LDD2132  [6]
 LDCM0025  4SU-RNA DM93 C256(4.43)  LDD0170  [8]
 LDCM0026  4SU-RNA+native RNA HEK-293T C256(2.61)  LDD0169  [8]
 LDCM0214  AC1 HCT 116 C134(0.97); C256(1.19)  LDD0531  [10]
 LDCM0215  AC10 HCT 116 C134(0.78); C256(1.35)  LDD0532  [10]
 LDCM0216  AC100 HCT 116 C134(0.39); C256(0.98)  LDD0533  [10]
 LDCM0217  AC101 HCT 116 C134(0.45); C256(0.83)  LDD0534  [10]
 LDCM0218  AC102 HCT 116 C134(0.34); C256(0.84)  LDD0535  [10]
 LDCM0219  AC103 HCT 116 C134(0.32); C256(0.96)  LDD0536  [10]
 LDCM0220  AC104 HCT 116 C134(0.35); C256(0.96)  LDD0537  [10]
 LDCM0221  AC105 HCT 116 C134(0.28); C256(0.87)  LDD0538  [10]
 LDCM0222  AC106 HCT 116 C134(0.31); C256(0.90)  LDD0539  [10]
 LDCM0223  AC107 HCT 116 C134(0.31); C256(0.83)  LDD0540  [10]
 LDCM0224  AC108 HCT 116 C134(0.57); C256(0.85)  LDD0541  [10]
 LDCM0225  AC109 HCT 116 C134(0.57); C256(0.73)  LDD0542  [10]
 LDCM0226  AC11 HCT 116 C134(0.89); C256(1.26)  LDD0543  [10]
 LDCM0227  AC110 HCT 116 C134(0.55); C256(0.85)  LDD0544  [10]
 LDCM0228  AC111 HCT 116 C134(0.48); C256(0.73)  LDD0545  [10]
 LDCM0229  AC112 HCT 116 C134(0.32); C256(0.65)  LDD0546  [10]
 LDCM0230  AC113 HCT 116 C134(0.79); C256(1.11)  LDD0547  [10]
 LDCM0231  AC114 HCT 116 C134(0.56); C256(1.15)  LDD0548  [10]
 LDCM0232  AC115 HCT 116 C134(0.48); C256(1.20)  LDD0549  [10]
 LDCM0233  AC116 HCT 116 C134(0.51); C256(1.25)  LDD0550  [10]
 LDCM0234  AC117 HCT 116 C134(0.60); C256(1.00)  LDD0551  [10]
 LDCM0235  AC118 HCT 116 C134(0.70); C256(1.22)  LDD0552  [10]
 LDCM0236  AC119 HCT 116 C134(0.60); C256(1.22)  LDD0553  [10]
 LDCM0237  AC12 HCT 116 C134(1.00); C256(1.40)  LDD0554  [10]
 LDCM0238  AC120 HCT 116 C134(0.56); C256(1.06)  LDD0555  [10]
 LDCM0239  AC121 HCT 116 C134(0.73); C256(1.09)  LDD0556  [10]
 LDCM0240  AC122 HCT 116 C134(0.67); C256(1.18)  LDD0557  [10]
 LDCM0241  AC123 HCT 116 C134(0.74); C256(1.30)  LDD0558  [10]
 LDCM0242  AC124 HCT 116 C134(0.76); C256(1.01)  LDD0559  [10]
 LDCM0243  AC125 HCT 116 C134(0.69); C256(1.42)  LDD0560  [10]
 LDCM0244  AC126 HCT 116 C134(0.52); C256(1.30)  LDD0561  [10]
 LDCM0245  AC127 HCT 116 C134(0.47); C256(1.27)  LDD0562  [10]
 LDCM0246  AC128 HCT 116 C134(0.78); C256(1.45)  LDD0563  [10]
 LDCM0247  AC129 HCT 116 C134(1.09); C256(1.32)  LDD0564  [10]
 LDCM0249  AC130 HCT 116 C134(0.80); C256(1.30)  LDD0566  [10]
 LDCM0250  AC131 HCT 116 C134(1.23); C256(1.18)  LDD0567  [10]
 LDCM0251  AC132 HCT 116 C134(1.09); C256(1.17)  LDD0568  [10]
 LDCM0252  AC133 HCT 116 C134(0.89); C256(1.24)  LDD0569  [10]
 LDCM0253  AC134 HCT 116 C134(0.82); C256(1.14)  LDD0570  [10]
 LDCM0254  AC135 HCT 116 C134(0.79); C256(1.20)  LDD0571  [10]
 LDCM0255  AC136 HCT 116 C134(0.88); C256(1.22)  LDD0572  [10]
 LDCM0256  AC137 HCT 116 C134(0.93); C256(1.13)  LDD0573  [10]
 LDCM0257  AC138 HCT 116 C134(0.86); C256(1.15)  LDD0574  [10]
 LDCM0258  AC139 HCT 116 C134(0.90); C256(1.20)  LDD0575  [10]
 LDCM0259  AC14 HCT 116 C134(0.89); C256(1.13)  LDD0576  [10]
 LDCM0260  AC140 HCT 116 C134(0.81); C256(1.35)  LDD0577  [10]
 LDCM0261  AC141 HCT 116 C134(0.87); C256(1.20)  LDD0578  [10]
 LDCM0262  AC142 HCT 116 C134(1.39); C256(1.13)  LDD0579  [10]
 LDCM0263  AC143 HCT 116 C134(0.73); C256(0.78)  LDD0580  [10]
 LDCM0264  AC144 HCT 116 C134(0.42); C256(0.95)  LDD0581  [10]
 LDCM0265  AC145 HCT 116 C134(0.54); C256(1.13)  LDD0582  [10]
 LDCM0266  AC146 HCT 116 C134(0.44); C256(1.08)  LDD0583  [10]
 LDCM0267  AC147 HCT 116 C134(0.40); C256(0.96)  LDD0584  [10]
 LDCM0268  AC148 HCT 116 C134(0.39); C256(1.13)  LDD0585  [10]
 LDCM0269  AC149 HCT 116 C134(0.37); C256(0.72)  LDD0586  [10]
 LDCM0270  AC15 HCT 116 C134(0.76); C256(1.25)  LDD0587  [10]
 LDCM0271  AC150 HCT 116 C134(0.56); C256(0.74)  LDD0588  [10]
 LDCM0272  AC151 HCT 116 C134(0.51); C256(0.95)  LDD0589  [10]
 LDCM0273  AC152 HCT 116 C134(0.42); C256(0.94)  LDD0590  [10]
 LDCM0274  AC153 HCT 116 C134(0.43); C256(1.26)  LDD0591  [10]
 LDCM0621  AC154 HCT 116 C134(0.44); C256(0.80)  LDD2158  [10]
 LDCM0622  AC155 HCT 116 C134(0.42); C256(0.81)  LDD2159  [10]
 LDCM0623  AC156 HCT 116 C134(0.73); C256(0.73)  LDD2160  [10]
 LDCM0624  AC157 HCT 116 C134(0.83); C256(0.79)  LDD2161  [10]
 LDCM0276  AC17 HCT 116 C134(0.79); C256(1.26)  LDD0593  [10]
 LDCM0277  AC18 HCT 116 C134(0.57); C256(1.30)  LDD0594  [10]
 LDCM0278  AC19 HCT 116 C134(0.67); C256(1.19)  LDD0595  [10]
 LDCM0279  AC2 HCT 116 C134(0.80); C256(1.06)  LDD0596  [10]
 LDCM0280  AC20 HCT 116 C134(0.81); C256(1.07)  LDD0597  [10]
 LDCM0281  AC21 HCT 116 C134(0.70); C256(1.71)  LDD0598  [10]
 LDCM0282  AC22 HCT 116 C134(0.84); C256(1.21)  LDD0599  [10]
 LDCM0283  AC23 HCT 116 C134(0.78); C256(1.10)  LDD0600  [10]
 LDCM0284  AC24 HCT 116 C134(0.90); C256(1.18)  LDD0601  [10]
 LDCM0285  AC25 HCT 116 C134(0.95); C256(1.11)  LDD0602  [10]
 LDCM0286  AC26 HCT 116 C134(0.65); C256(0.96)  LDD0603  [10]
 LDCM0287  AC27 HCT 116 C134(0.71); C256(0.90)  LDD0604  [10]
 LDCM0288  AC28 HCT 116 C134(0.66); C256(1.11)  LDD0605  [10]
 LDCM0289  AC29 HCT 116 C134(0.65); C256(1.01)  LDD0606  [10]
 LDCM0290  AC3 HCT 116 C134(0.91); C256(1.33)  LDD0607  [10]
 LDCM0291  AC30 HCT 116 C134(0.57); C256(0.76)  LDD0608  [10]
 LDCM0292  AC31 HCT 116 C134(0.71); C256(0.95)  LDD0609  [10]
 LDCM0293  AC32 HCT 116 C134(0.58); C256(0.91)  LDD0610  [10]
 LDCM0294  AC33 HCT 116 C134(0.66); C256(0.90)  LDD0611  [10]
 LDCM0295  AC34 HCT 116 C134(0.64); C256(0.82)  LDD0612  [10]
 LDCM0296  AC35 HCT 116 C134(1.09); C256(1.53)  LDD0613  [10]
 LDCM0297  AC36 HCT 116 C134(1.01); C256(1.26)  LDD0614  [10]
 LDCM0298  AC37 HCT 116 C134(0.91); C256(1.31)  LDD0615  [10]
 LDCM0299  AC38 HCT 116 C134(1.09); C256(1.10)  LDD0616  [10]
 LDCM0300  AC39 HCT 116 C134(0.87); C256(1.33)  LDD0617  [10]
 LDCM0301  AC4 HCT 116 C134(0.82); C256(1.15)  LDD0618  [10]
 LDCM0302  AC40 HCT 116 C134(0.95); C256(1.05)  LDD0619  [10]
 LDCM0303  AC41 HCT 116 C134(0.94); C256(1.06)  LDD0620  [10]
 LDCM0304  AC42 HCT 116 C134(0.89); C256(1.08)  LDD0621  [10]
 LDCM0305  AC43 HCT 116 C134(1.09); C256(1.11)  LDD0622  [10]
 LDCM0306  AC44 HCT 116 C134(0.91); C256(1.46)  LDD0623  [10]
 LDCM0307  AC45 HCT 116 C134(0.83); C256(1.49)  LDD0624  [10]
 LDCM0308  AC46 HCT 116 C256(0.67); C134(0.88)  LDD0625  [10]
 LDCM0309  AC47 HCT 116 C134(0.78); C256(0.96)  LDD0626  [10]
 LDCM0310  AC48 HCT 116 C256(0.86); C134(0.94)  LDD0627  [10]
 LDCM0311  AC49 HCT 116 C256(0.75); C134(0.88)  LDD0628  [10]
 LDCM0312  AC5 HCT 116 C134(0.86); C256(1.36)  LDD0629  [10]
 LDCM0313  AC50 HCT 116 C256(0.83); C134(0.86)  LDD0630  [10]
 LDCM0314  AC51 HCT 116 C256(0.78); C134(0.93)  LDD0631  [10]
 LDCM0315  AC52 HCT 116 C256(0.75); C134(0.79)  LDD0632  [10]
 LDCM0316  AC53 HCT 116 C134(0.80); C256(0.87)  LDD0633  [10]
 LDCM0317  AC54 HCT 116 C134(0.76); C256(0.89)  LDD0634  [10]
 LDCM0318  AC55 HCT 116 C134(0.89); C256(0.96)  LDD0635  [10]
 LDCM0319  AC56 HCT 116 C256(0.75); C134(0.85)  LDD0636  [10]
 LDCM0320  AC57 HCT 116 C134(0.71); C256(1.10)  LDD0637  [10]
 LDCM0321  AC58 HCT 116 C134(0.65); C256(1.09)  LDD0638  [10]
 LDCM0322  AC59 HCT 116 C134(0.76); C256(1.13)  LDD0639  [10]
 LDCM0323  AC6 HCT 116 C134(0.69); C256(0.89)  LDD0640  [10]
 LDCM0324  AC60 HCT 116 C134(0.89); C256(1.04)  LDD0641  [10]
 LDCM0325  AC61 HCT 116 C134(0.69); C256(1.08)  LDD0642  [10]
 LDCM0326  AC62 HCT 116 C134(0.78); C256(1.07)  LDD0643  [10]
 LDCM0327  AC63 HCT 116 C134(0.84); C256(1.07)  LDD0644  [10]
 LDCM0328  AC64 HCT 116 C134(0.84); C256(1.15)  LDD0645  [10]
 LDCM0329  AC65 HCT 116 C134(0.66); C256(1.17)  LDD0646  [10]
 LDCM0330  AC66 HCT 116 C134(0.70); C256(1.15)  LDD0647  [10]
 LDCM0331  AC67 HCT 116 C134(0.68); C256(1.26)  LDD0648  [10]
 LDCM0332  AC68 HCT 116 C134(0.72); C256(1.02)  LDD0649  [10]
 LDCM0333  AC69 HCT 116 C134(0.72); C256(1.23)  LDD0650  [10]
 LDCM0334  AC7 HCT 116 C134(0.79); C256(1.03)  LDD0651  [10]
 LDCM0335  AC70 HCT 116 C134(0.60); C256(1.03)  LDD0652  [10]
 LDCM0336  AC71 HCT 116 C134(0.88); C256(1.21)  LDD0653  [10]
 LDCM0337  AC72 HCT 116 C134(0.62); C256(1.05)  LDD0654  [10]
 LDCM0338  AC73 HCT 116 C134(0.67); C256(0.97)  LDD0655  [10]
 LDCM0339  AC74 HCT 116 C134(0.82); C256(1.29)  LDD0656  [10]
 LDCM0340  AC75 HCT 116 C134(0.80); C256(1.00)  LDD0657  [10]
 LDCM0341  AC76 HCT 116 C134(0.83); C256(1.36)  LDD0658  [10]
 LDCM0342  AC77 HCT 116 C134(0.73); C256(1.00)  LDD0659  [10]
 LDCM0343  AC78 HCT 116 C134(0.73); C256(0.93)  LDD0660  [10]
 LDCM0344  AC79 HCT 116 C134(0.74); C256(1.07)  LDD0661  [10]
 LDCM0345  AC8 HCT 116 C134(0.76); C256(1.08)  LDD0662  [10]
 LDCM0346  AC80 HCT 116 C134(0.89); C256(1.12)  LDD0663  [10]
 LDCM0347  AC81 HCT 116 C134(0.90); C256(1.10)  LDD0664  [10]
 LDCM0348  AC82 HCT 116 C134(0.80); C256(1.20)  LDD0665  [10]
 LDCM0349  AC83 HCT 116 C134(0.52); C256(1.02)  LDD0666  [10]
 LDCM0350  AC84 HCT 116 C134(0.52); C256(1.05)  LDD0667  [10]
 LDCM0351  AC85 HCT 116 C134(0.56); C256(1.11)  LDD0668  [10]
 LDCM0352  AC86 HCT 116 C134(0.64); C256(0.82)  LDD0669  [10]
 LDCM0353  AC87 HCT 116 C134(1.02); C256(1.18)  LDD0670  [10]
 LDCM0354  AC88 HCT 116 C134(0.67); C256(1.01)  LDD0671  [10]
 LDCM0355  AC89 HCT 116 C134(0.55); C256(0.99)  LDD0672  [10]
 LDCM0357  AC90 HCT 116 C256(1.06); C134(1.08)  LDD0674  [10]
 LDCM0358  AC91 HCT 116 C134(0.51); C256(1.41)  LDD0675  [10]
 LDCM0359  AC92 HCT 116 C134(0.53); C256(1.03)  LDD0676  [10]
 LDCM0360  AC93 HCT 116 C134(0.62); C256(1.05)  LDD0677  [10]
 LDCM0361  AC94 HCT 116 C134(0.66); C256(1.27)  LDD0678  [10]
 LDCM0362  AC95 HCT 116 C134(0.99); C256(1.05)  LDD0679  [10]
 LDCM0363  AC96 HCT 116 C134(0.53); C256(1.34)  LDD0680  [10]
 LDCM0364  AC97 HCT 116 C134(0.54); C256(0.97)  LDD0681  [10]
 LDCM0365  AC98 HCT 116 C134(0.29); C256(1.13)  LDD0682  [10]
 LDCM0366  AC99 HCT 116 C134(0.48); C256(0.78)  LDD0683  [10]
 LDCM0520  AKOS000195272 MDA-MB-231 C256(0.79)  LDD2113  [6]
 LDCM0248  AKOS034007472 HCT 116 C134(0.85); C256(1.13)  LDD0565  [10]
 LDCM0356  AKOS034007680 HCT 116 C134(1.07); C256(1.20)  LDD0673  [10]
 LDCM0275  AKOS034007705 HCT 116 C134(0.65); C256(1.07)  LDD0592  [10]
 LDCM0156  Aniline NCI-H1299 13.67  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C256(0.78)  LDD2091  [6]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [20]
 LDCM0367  CL1 HCT 116 C256(0.95); C134(1.24)  LDD0684  [10]
 LDCM0368  CL10 HCT 116 C134(0.77); C256(0.86)  LDD0685  [10]
 LDCM0369  CL100 HCT 116 C134(0.99); C256(1.19)  LDD0686  [10]
 LDCM0370  CL101 HCT 116 C134(0.74); C256(0.93)  LDD0687  [10]
 LDCM0371  CL102 HCT 116 C134(0.86); C256(1.12)  LDD0688  [10]
 LDCM0372  CL103 HCT 116 C134(0.94); C256(1.21)  LDD0689  [10]
 LDCM0373  CL104 HCT 116 C134(0.82); C256(1.04)  LDD0690  [10]
 LDCM0374  CL105 HCT 116 C134(0.53); C256(1.25)  LDD0691  [10]
 LDCM0375  CL106 HCT 116 C134(0.45); C256(1.87)  LDD0692  [10]
 LDCM0376  CL107 HCT 116 C134(0.46); C256(1.22)  LDD0693  [10]
 LDCM0377  CL108 HCT 116 C134(0.47); C256(1.36)  LDD0694  [10]
 LDCM0378  CL109 HCT 116 C134(0.62); C256(1.09)  LDD0695  [10]
 LDCM0379  CL11 HCT 116 C134(0.78); C256(1.17)  LDD0696  [10]
 LDCM0380  CL110 HCT 116 C134(0.50); C256(1.53)  LDD0697  [10]
 LDCM0381  CL111 HCT 116 C134(0.67); C256(0.98)  LDD0698  [10]
 LDCM0382  CL112 HCT 116 C134(0.87); C256(1.02)  LDD0699  [10]
 LDCM0383  CL113 HCT 116 C134(0.58); C256(0.73)  LDD0700  [10]
 LDCM0384  CL114 HCT 116 C134(0.63); C256(0.85)  LDD0701  [10]
 LDCM0385  CL115 HCT 116 C134(0.64); C256(0.75)  LDD0702  [10]
 LDCM0386  CL116 HCT 116 C134(0.71); C256(0.86)  LDD0703  [10]
 LDCM0387  CL117 HCT 116 C134(0.87); C256(1.15)  LDD0704  [10]
 LDCM0388  CL118 HCT 116 C134(0.85); C256(1.13)  LDD0705  [10]
 LDCM0389  CL119 HCT 116 C134(0.92); C256(1.22)  LDD0706  [10]
 LDCM0390  CL12 HCT 116 C134(0.78); C256(0.93)  LDD0707  [10]
 LDCM0391  CL120 HCT 116 C134(1.02); C256(1.20)  LDD0708  [10]
 LDCM0392  CL121 HCT 116 C256(0.63); C134(0.93)  LDD0709  [10]
 LDCM0393  CL122 HCT 116 C256(0.68); C134(0.89)  LDD0710  [10]
 LDCM0394  CL123 HCT 116 C134(0.77); C256(0.80)  LDD0711  [10]
 LDCM0395  CL124 HCT 116 C134(0.73); C256(0.75)  LDD0712  [10]
 LDCM0396  CL125 HCT 116 C256(0.94); C134(0.98)  LDD0713  [10]
 LDCM0397  CL126 HCT 116 C134(0.76); C256(0.81)  LDD0714  [10]
 LDCM0398  CL127 HCT 116 C134(0.76); C256(0.91)  LDD0715  [10]
 LDCM0399  CL128 HCT 116 C134(0.68); C256(1.07)  LDD0716  [10]
 LDCM0400  CL13 HCT 116 C134(0.83); C256(1.01)  LDD0717  [10]
 LDCM0401  CL14 HCT 116 C134(0.95); C256(0.97)  LDD0718  [10]
 LDCM0402  CL15 HCT 116 C134(0.88); C256(1.19)  LDD0719  [10]
 LDCM0403  CL16 HCT 116 C256(0.92)  LDD0720  [10]
 LDCM0404  CL17 HCT 116 C256(1.10)  LDD0721  [10]
 LDCM0405  CL18 HCT 116 C256(1.15)  LDD0722  [10]
 LDCM0406  CL19 HCT 116 C256(1.26)  LDD0723  [10]
 LDCM0407  CL2 HCT 116 C256(0.97); C134(1.15)  LDD0724  [10]
 LDCM0408  CL20 HCT 116 C256(0.91)  LDD0725  [10]
 LDCM0409  CL21 HCT 116 C256(1.09)  LDD0726  [10]
 LDCM0410  CL22 HCT 116 C256(0.95)  LDD0727  [10]
 LDCM0411  CL23 HCT 116 C256(0.83)  LDD0728  [10]
 LDCM0412  CL24 HCT 116 C256(1.11)  LDD0729  [10]
 LDCM0413  CL25 HCT 116 C256(0.91)  LDD0730  [10]
 LDCM0414  CL26 HCT 116 C256(0.94)  LDD0731  [10]
 LDCM0415  CL27 HCT 116 C256(1.07)  LDD0732  [10]
 LDCM0416  CL28 HCT 116 C256(0.89)  LDD0733  [10]
 LDCM0417  CL29 HCT 116 C256(0.98)  LDD0734  [10]
 LDCM0418  CL3 HCT 116 C134(0.95); C256(1.19)  LDD0735  [10]
 LDCM0419  CL30 HCT 116 C256(1.22)  LDD0736  [10]
 LDCM0420  CL31 HCT 116 C134(0.58); C256(1.13)  LDD0737  [10]
 LDCM0421  CL32 HCT 116 C134(0.57); C256(0.95)  LDD0738  [10]
 LDCM0422  CL33 HCT 116 C134(0.54); C256(0.79)  LDD0739  [10]
 LDCM0423  CL34 HCT 116 C134(0.49); C256(0.84)  LDD0740  [10]
 LDCM0424  CL35 HCT 116 C134(0.47); C256(0.89)  LDD0741  [10]
 LDCM0425  CL36 HCT 116 C134(0.46); C256(1.13)  LDD0742  [10]
 LDCM0426  CL37 HCT 116 C134(0.45); C256(1.07)  LDD0743  [10]
 LDCM0428  CL39 HCT 116 C134(0.51); C256(0.96)  LDD0745  [10]
 LDCM0429  CL4 HCT 116 C134(1.03); C256(0.97)  LDD0746  [10]
 LDCM0430  CL40 HCT 116 C134(0.46); C256(1.04)  LDD0747  [10]
 LDCM0431  CL41 HCT 116 C134(0.52); C256(0.79)  LDD0748  [10]
 LDCM0432  CL42 HCT 116 C134(0.49); C256(1.07)  LDD0749  [10]
 LDCM0433  CL43 HCT 116 C134(0.53); C256(0.97)  LDD0750  [10]
 LDCM0434  CL44 HCT 116 C134(0.51); C256(1.13)  LDD0751  [10]
 LDCM0435  CL45 HCT 116 C134(0.50); C256(1.09)  LDD0752  [10]
 LDCM0436  CL46 HCT 116 C134(1.26); C256(0.83)  LDD0753  [10]
 LDCM0437  CL47 HCT 116 C134(1.42); C256(0.87)  LDD0754  [10]
 LDCM0438  CL48 HCT 116 C134(1.31); C256(0.80)  LDD0755  [10]
 LDCM0439  CL49 HCT 116 C134(1.02); C256(0.80)  LDD0756  [10]
 LDCM0440  CL5 HCT 116 C134(0.90); C256(1.03)  LDD0757  [10]
 LDCM0441  CL50 HCT 116 C134(1.21); C256(0.92)  LDD0758  [10]
 LDCM0442  CL51 HCT 116 C134(1.33); C256(1.01)  LDD0759  [10]
 LDCM0443  CL52 HCT 116 C134(1.31); C256(0.83)  LDD0760  [10]
 LDCM0444  CL53 HCT 116 C134(1.33); C256(0.83)  LDD0761  [10]
 LDCM0445  CL54 HCT 116 C134(1.31); C256(0.72)  LDD0762  [10]
 LDCM0446  CL55 HCT 116 C134(1.34); C256(0.80)  LDD0763  [10]
 LDCM0447  CL56 HCT 116 C134(0.88); C256(0.91)  LDD0764  [10]
 LDCM0448  CL57 HCT 116 C134(1.19); C256(0.76)  LDD0765  [10]
 LDCM0449  CL58 HCT 116 C134(1.29); C256(0.72)  LDD0766  [10]
 LDCM0450  CL59 HCT 116 C134(1.02); C256(0.81)  LDD0767  [10]
 LDCM0451  CL6 HCT 116 C134(0.96); C256(0.92)  LDD0768  [10]
 LDCM0452  CL60 HCT 116 C134(1.11); C256(0.79)  LDD0769  [10]
 LDCM0453  CL61 HCT 116 C134(0.84); C256(1.17)  LDD0770  [10]
 LDCM0454  CL62 HCT 116 C134(0.76); C256(0.94)  LDD0771  [10]
 LDCM0455  CL63 HCT 116 C134(0.67); C256(0.85)  LDD0772  [10]
 LDCM0456  CL64 HCT 116 C134(0.68); C256(0.96)  LDD0773  [10]
 LDCM0457  CL65 HCT 116 C134(0.88); C256(1.03)  LDD0774  [10]
 LDCM0458  CL66 HCT 116 C134(0.67); C256(1.19)  LDD0775  [10]
 LDCM0459  CL67 HCT 116 C134(0.66); C256(1.02)  LDD0776  [10]
 LDCM0460  CL68 HCT 116 C134(0.65); C256(0.90)  LDD0777  [10]
 LDCM0461  CL69 HCT 116 C134(0.94); C256(1.46)  LDD0778  [10]
 LDCM0462  CL7 HCT 116 C134(0.88); C256(1.14)  LDD0779  [10]
 LDCM0463  CL70 HCT 116 C134(0.74); C256(1.41)  LDD0780  [10]
 LDCM0464  CL71 HCT 116 C134(0.62); C256(0.80)  LDD0781  [10]
 LDCM0465  CL72 HCT 116 C134(0.78); C256(0.85)  LDD0782  [10]
 LDCM0466  CL73 HCT 116 C134(0.77); C256(1.00)  LDD0783  [10]
 LDCM0467  CL74 HCT 116 C134(0.71); C256(1.01)  LDD0784  [10]
 LDCM0469  CL76 HCT 116 C134(0.77); C256(1.20)  LDD0786  [10]
 LDCM0470  CL77 HCT 116 C134(0.84); C256(0.87)  LDD0787  [10]
 LDCM0471  CL78 HCT 116 C134(0.69); C256(0.94)  LDD0788  [10]
 LDCM0472  CL79 HCT 116 C134(0.67); C256(0.97)  LDD0789  [10]
 LDCM0473  CL8 HCT 116 C134(0.75); C256(0.90)  LDD0790  [10]
 LDCM0474  CL80 HCT 116 C134(0.83); C256(1.25)  LDD0791  [10]
 LDCM0475  CL81 HCT 116 C134(0.71); C256(0.99)  LDD0792  [10]
 LDCM0476  CL82 HCT 116 C134(0.63); C256(1.02)  LDD0793  [10]
 LDCM0477  CL83 HCT 116 C134(0.57); C256(1.11)  LDD0794  [10]
 LDCM0478  CL84 HCT 116 C134(0.73); C256(1.51)  LDD0795  [10]
 LDCM0479  CL85 HCT 116 C134(0.61); C256(1.10)  LDD0796  [10]
 LDCM0480  CL86 HCT 116 C134(0.72); C256(1.13)  LDD0797  [10]
 LDCM0481  CL87 HCT 116 C134(0.68); C256(0.91)  LDD0798  [10]
 LDCM0482  CL88 HCT 116 C134(0.65); C256(1.01)  LDD0799  [10]
 LDCM0483  CL89 HCT 116 C134(0.70); C256(1.24)  LDD0800  [10]
 LDCM0484  CL9 HCT 116 C134(0.90); C256(0.87)  LDD0801  [10]
 LDCM0485  CL90 HCT 116 C134(0.91); C256(1.18)  LDD0802  [10]
 LDCM0486  CL91 HCT 116 C134(0.73); C256(1.12)  LDD0803  [10]
 LDCM0487  CL92 HCT 116 C134(0.78); C256(1.03)  LDD0804  [10]
 LDCM0488  CL93 HCT 116 C134(0.99); C256(1.15)  LDD0805  [10]
 LDCM0489  CL94 HCT 116 C134(1.07); C256(1.33)  LDD0806  [10]
 LDCM0490  CL95 HCT 116 C134(0.69); C256(1.26)  LDD0807  [10]
 LDCM0491  CL96 HCT 116 C134(0.74); C256(0.96)  LDD0808  [10]
 LDCM0492  CL97 HCT 116 C134(0.70); C256(0.93)  LDD0809  [10]
 LDCM0493  CL98 HCT 116 C134(0.88); C256(0.97)  LDD0810  [10]
 LDCM0494  CL99 HCT 116 C134(0.90); C256(1.11)  LDD0811  [10]
 LDCM0495  E2913 HEK-293T C256(0.96); C134(1.01)  LDD1698  [29]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C256(3.24)  LDD1702  [6]
 LDCM0625  F8 Ramos C256(0.46)  LDD2187  [30]
 LDCM0572  Fragment10 MDA-MB-231 C256(2.33)  LDD1389  [31]
 LDCM0573  Fragment11 MDA-MB-231 C256(1.72)  LDD1391  [31]
 LDCM0574  Fragment12 MDA-MB-231 C256(2.36)  LDD1393  [31]
 LDCM0575  Fragment13 MDA-MB-231 C256(1.13)  LDD1395  [31]
 LDCM0576  Fragment14 MDA-MB-231 C256(3.19)  LDD1397  [31]
 LDCM0579  Fragment20 Ramos C256(3.57)  LDD1403  [31]
 LDCM0580  Fragment21 MDA-MB-231 C256(1.49)  LDD1404  [31]
 LDCM0581  Fragment22 MDA-MB-231 C256(1.04)  LDD1406  [31]
 LDCM0582  Fragment23 MDA-MB-231 C256(3.45)  LDD1408  [31]
 LDCM0583  Fragment24 Ramos C256(1.69)  LDD1410  [31]
 LDCM0584  Fragment25 MDA-MB-231 C256(0.82)  LDD1411  [31]
 LDCM0585  Fragment26 Ramos C256(0.88)  LDD1412  [31]
 LDCM0578  Fragment27 MDA-MB-231 C256(0.70)  LDD1401  [31]
 LDCM0586  Fragment28 MDA-MB-231 C256(0.84)  LDD1415  [31]
 LDCM0587  Fragment29 Ramos C256(0.81)  LDD1418  [31]
 LDCM0588  Fragment30 MDA-MB-231 C256(0.79)  LDD1419  [31]
 LDCM0589  Fragment31 MDA-MB-231 C256(2.83)  LDD1421  [31]
 LDCM0590  Fragment32 MDA-MB-231 C256(2.34)  LDD1423  [31]
 LDCM0468  Fragment33 HCT 116 C134(0.71); C256(1.14)  LDD0785  [10]
 LDCM0592  Fragment34 MDA-MB-231 C256(0.95)  LDD1427  [31]
 LDCM0593  Fragment35 Ramos C256(0.83)  LDD1430  [31]
 LDCM0595  Fragment37 Ramos C256(0.84)  LDD1432  [31]
 LDCM0596  Fragment38 MDA-MB-231 C256(1.25)  LDD1433  [31]
 LDCM0597  Fragment39 MDA-MB-231 C256(1.56)  LDD1435  [31]
 LDCM0566  Fragment4 MDA-MB-231 C256(1.71)  LDD1378  [31]
 LDCM0598  Fragment40 MDA-MB-231 C256(0.89)  LDD1436  [31]
 LDCM0599  Fragment41 MDA-MB-231 C256(1.62)  LDD1438  [31]
 LDCM0600  Fragment42 Ramos C256(0.82)  LDD1440  [31]
 LDCM0601  Fragment43 Ramos C256(1.23)  LDD1442  [31]
 LDCM0602  Fragment44 MDA-MB-231 C256(0.85)  LDD1443  [31]
 LDCM0603  Fragment45 MDA-MB-231 C256(3.68)  LDD1444  [31]
 LDCM0604  Fragment46 MDA-MB-231 C256(0.98)  LDD1445  [31]
 LDCM0605  Fragment47 MDA-MB-231 C256(1.19)  LDD1446  [31]
 LDCM0607  Fragment49 MDA-MB-231 C256(3.36)  LDD1448  [31]
 LDCM0608  Fragment50 MDA-MB-231 C256(2.21)  LDD1449  [31]
 LDCM0427  Fragment51 HCT 116 C134(0.48); C256(0.98)  LDD0744  [10]
 LDCM0610  Fragment52 MDA-MB-231 C256(1.21)  LDD1452  [31]
 LDCM0611  Fragment53 MDA-MB-231 C256(0.90)  LDD1454  [31]
 LDCM0612  Fragment54 MDA-MB-231 C256(1.11)  LDD1456  [31]
 LDCM0613  Fragment55 MDA-MB-231 C256(0.93)  LDD1457  [31]
 LDCM0614  Fragment56 MDA-MB-231 C256(0.90)  LDD1458  [31]
 LDCM0569  Fragment7 Ramos C256(1.34)  LDD2186  [30]
 LDCM0570  Fragment8 MDA-MB-231 C256(1.46)  LDD1385  [31]
 LDCM0571  Fragment9 MDA-MB-231 C256(2.83)  LDD1387  [31]
 LDCM0116  HHS-0101 DM93 Y157(0.98)  LDD0264  [9]
 LDCM0117  HHS-0201 DM93 Y157(0.86)  LDD0265  [9]
 LDCM0118  HHS-0301 DM93 Y157(0.50)  LDD0266  [9]
 LDCM0119  HHS-0401 DM93 Y157(0.63)  LDD0267  [9]
 LDCM0120  HHS-0701 DM93 Y157(0.81)  LDD0268  [9]
 LDCM0107  IAA HeLa N.A.  LDD0221  [20]
 LDCM0022  KB02 HCT 116 C256(2.41)  LDD0080  [10]
 LDCM0023  KB03 HCT 116 C256(5.58)  LDD0081  [10]
 LDCM0024  KB05 HCT 116 C256(5.46)  LDD0082  [10]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C256(0.88)  LDD2102  [6]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C256(0.78)  LDD2121  [6]
 LDCM0109  NEM HeLa H95(0.00); H199(0.00)  LDD0223  [20]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C256(0.92)  LDD2089  [6]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C256(0.89)  LDD2092  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C256(1.10)  LDD2093  [6]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C256(0.88)  LDD2094  [6]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C256(0.79)  LDD2097  [6]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C256(1.18)  LDD2098  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C256(1.34)  LDD2099  [6]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C256(0.75)  LDD2100  [6]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C256(0.89)  LDD2101  [6]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C256(0.78)  LDD2104  [6]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C256(1.03)  LDD2105  [6]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C256(0.44)  LDD2106  [6]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C256(0.69)  LDD2108  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C256(0.77)  LDD2109  [6]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C256(0.73)  LDD2110  [6]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C256(1.11)  LDD2111  [6]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C256(0.65)  LDD2114  [6]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C256(0.43)  LDD2115  [6]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C256(0.67)  LDD2118  [6]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C256(1.88)  LDD2119  [6]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C256(0.79)  LDD2120  [6]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C256(0.57)  LDD2124  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C256(0.92)  LDD2125  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C256(1.14)  LDD2127  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C256(1.10)  LDD2129  [6]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C256(0.58)  LDD2133  [6]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C256(0.86)  LDD2134  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C256(1.51)  LDD2135  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C256(1.21)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C256(0.94)  LDD2137  [6]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C256(2.39)  LDD1700  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C256(0.93)  LDD2140  [6]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C256(0.69)  LDD2143  [6]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C256(1.97)  LDD2144  [6]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C256(5.96)  LDD2145  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C256(1.04)  LDD2146  [6]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C256(0.42)  LDD2148  [6]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C256(0.50)  LDD2150  [6]
 LDCM0019  Staurosporine Hep-G2 N.A.  LDD0083  [27]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Anterior gradient protein 2 homolog (AGR2) AGR family O95994
Eukaryotic translation initiation factor 3 subunit F (EIF3F) EIF-3 subunit F family O00303
Caspase-6 (CASP6) Peptidase C14A family P55212
Serine protease HTRA2, mitochondrial (HTRA2) Peptidase S1C family O43464
Serine/threonine-protein kinase N1 (PKN1) AGC Ser/Thr protein kinase family Q16512
Cyclin-dependent kinase 11B (CDK11B) CMGC Ser/Thr protein kinase family P21127
Ribose-phosphate pyrophosphokinase 1 (PRPS1) Ribose-phosphate pyrophosphokinase family P60891
E3 ubiquitin-protein ligase makorin-2 (MKRN2) . Q9H000
Sulfite oxidase, mitochondrial (SUOX) . P51687
Transporter and channel
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cytochrome c (CYCS) Cytochrome c family P99999
Endophilin-B1 (SH3GLB1) Endophilin family Q9Y371
mRNA export factor GLE1 (GLE1) GLE1 family Q53GS7
Junctophilin-3 (JPH3) Junctophilin family Q8WXH2
Nucleoporin p54 (NUP54) NUP54 family Q7Z3B4
Nucleoporin p58/p45 (NUP58) NUP58 family Q9BVL2
Wolframin (WFS1) . O76024
Transcription factor
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Vascular endothelial zinc finger 1 (VEZF1) Krueppel C2H2-type zinc-finger protein family Q14119
POU domain, class 6, transcription factor 2 (POU6F2) POU transcription factor family P78424
Krueppel-like factor 11 (KLF11) Sp1 C2H2-type zinc-finger protein family O14901
Pre-B-cell leukemia transcription factor 4 (PBX4) TALE/PBX homeobox family Q9BYU1
Pogo transposable element with ZNF domain (POGZ) . Q7Z3K3
Other
Click To Hide/Show 21 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1 (ATXN1) ATXN1 family P54253
MutS protein homolog 4 (MSH4) DNA mismatch repair MutS family O15457
Guanine nucleotide exchange factor MSS4 (RABIF) DSS4/MSS4 family P47224
Eukaryotic translation initiation factor 3 subunit B (EIF3B) EIF-3 subunit B family P55884
Eukaryotic translation initiation factor 3 subunit H (EIF3H) EIF-3 subunit H family O15372
Eukaryotic translation initiation factor 3 subunit M (EIF3M) EIF-3 subunit M family Q7L2H7
Protein FAM222B (FAM222B) FAM222 family Q8WU58
Collagen alpha-2(I) chain (COL1A2) Fibrillar collagen family P08123
Axonemal dynein light intermediate polypeptide 1 (DNALI1) Inner dynein arm light chain family O14645
Myeloid-derived growth factor (MYDGF) MYDGF family Q969H8
Myozenin-1 (MYOZ1) Myozenin family Q9NP98
Ras and Rab interactor 1 (RIN1) RIN (Ras interaction/interference) family Q13671
Heat shock protein beta-1 (HSPB1) Small heat shock protein (HSP20) family P04792
Mitochondrial import inner membrane translocase subunit Tim10 B (TIMM10B) Small Tim family Q9Y5J6
UPF0500 protein C1orf216 (C1orf216) UPF0500 family Q8TAB5
Coiled-coil domain-containing protein 120 (CCDC120) . Q96HB5
F-box only protein 32 (FBXO32) . Q969P5
Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) . O14964
Receptor-transporting protein 5 (RTP5) . Q14D33
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699
TAR DNA-binding protein 43 (TARDBP) . Q13148

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Quercetin Small molecular drug DB04216

References

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3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
8 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
9 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
12 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
13 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
14 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
15 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
16 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
17 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
18 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
19 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
20 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
21 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
22 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
23 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
24 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
25 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
26 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
27 Comprehensive identification of staurosporine-binding kinases in the hepatocyte cell line HepG2 using Capture Compound Mass Spectrometry (CCMS). J Proteome Res. 2010 Feb 5;9(2):806-17. doi: 10.1021/pr9007333.
28 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
29 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
30 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
31 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.