Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IA-alkyne  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
Isotope tag
Competitor Name Fragment43  Competitor Info 
Competitor Concentration 500 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Lymph node
Disease Model Burkitt lymphoma [ICD-11:2A85]
Model Name Human burkitt lymphoma cell lysate (Ramos)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 67 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C126 20.0
 LDTP05992  Bleomycin hydrolase (BLMH) C73 20.0
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) C32 20.0
 LDTP02188  Protein disulfide-isomerase (P4HB) C397 20.0
 LDTP03521  Protein disulfide-isomerase A3 (PDIA3) C406 20.0
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C555 20.0
 LDTP06314  Protein disulfide-isomerase A6 (PDIA6) C55 20.0
 LDTP09067  Thioredoxin domain-containing protein 5 (TXNDC5) C350 20.0
 LDTP00701  D-3-phosphoglycerate dehydrogenase (PHGDH) C369 9.2
 LDTP10177  Medium-chain acyl-CoA ligase ACSF2, mitochondrial (ACSF2) C64 6.6
 LDTP04076  Mitogen-activated protein kinase 9 (MAPK9) C177 5.3
 LDTP11111  Tudor-interacting repair regulator protein (NUDT16L1) C88 5.3
 LDTP08181  Glutaredoxin-related protein 5, mitochondrial (GLRX5) C67 4.8
 LDTP10418  Mannose-1-phosphate guanyltransferase alpha (GMPPA) C389 4.2
 LDTP00089  Glycerol-3-phosphate phosphatase (PGP) C297 3.7
 LDTP04265  Serine--tRNA ligase, cytoplasmic (SARS1) C438 3.7
 LDTP07651  Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L) C906 3.7
 LDTP14535  6-phosphogluconolactonase (PGLS) C32 2.9
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C331 2.8
 LDTP03299  Cyclin-dependent kinase 2 (CDK2) C177 2.7
 LDTP17247  5'-nucleotidase domain-containing protein 1 (NT5DC1) C119 2.5
 LDTP02502  Thioredoxin (TXN) C32 2.5
 LDTP12960  [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial (PDP1) C149 2.5
 LDTP15311  Deaminated glutathione amidase (NIT1) C203 2.4
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C196 2.3
 LDTP10774  Elongation factor G, mitochondrial (GFM1) C153 2.3
 LDTP10954  3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10) C214 2.2
 LDTP02333  Glutathione S-transferase P (GSTP1) C48 2.2
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1) C442 2.1
 LDTP02580  C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1) C918 2.1
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C140 2.0
 LDTP11030  Serine/threonine-protein kinase VRK1 (VRK1) C50 2.0
 LDTP02022  Thymidine kinase, cytosolic (TK1) C66 1.9
 LDTP10386  ERO1-like protein alpha (ERO1A) C241 1.9
 LDTP05070  Ubiquitin-conjugating enzyme E2 L3 (UBE2L3) C86 1.7
 LDTP03223  Small ribosomal subunit protein uS3 (RPS3) C97 1.7
 LDTP00273  Dynamin-1-like protein (DNM1L) C367 1.6
 LDTP02580  C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1) C863 1.5
 LDTP04689  Adenosine kinase (ADK) C353 1.5
 LDTP17082  Isoamyl acetate-hydrolyzing esterase 1 homolog (IAH1) C137 1.4
 LDTP06338  Prostaglandin E synthase 3 (PTGES3) C58 1.2
 LDTP00246  Eukaryotic translation initiation factor 3 subunit F (EIF3F) C256 1.2
 LDTP10997  Protein arginine N-methyltransferase 1 (PRMT1) C109 1.2
 LDTP03400  Deoxycytidine kinase (DCK) C9 1.2
 LDTP04424  Galactokinase (GALK1) C182 1.2
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C376 1.2
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C347 1.2
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C347 1.2
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C119 1.1
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) C152 1.1
 LDTP05912  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) C113 1.1
 LDTP02672  Elongation factor 2 (EEF2) C41 1.1
 LDTP10801  ATPase WRNIP1 (WRNIP1) C272 1.1
 LDTP02765  Aldo-keto reductase family 1 member B1 (AKR1B1) C299 1.0
 LDTP02733  Pyruvate kinase PKM (PKM) C423 1.0
 LDTP04374  Dynamin-2 (DNM2) C27 1.0
 LDTP06621  Ubiquitin-conjugating enzyme E2 S (UBE2S) C118 1.0
 LDTP12428  Omega-amidase NIT2 (NIT2) C153 1.0
 LDTP03998  3-ketoacyl-CoA thiolase, mitochondrial (ACAA2) C92 1.0
 LDTP02022  Thymidine kinase, cytosolic (TK1) C230 1.0
 LDTP11388  N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15) C721 0.9
 LDTP03400  Deoxycytidine kinase (DCK) C45 0.9
 LDTP03152  Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT1) C102 0.9
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C315 0.9
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C129 0.8
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C295 0.7
 LDTP04251  Elongation factor Tu, mitochondrial (TUFM) C147 0.6
Transporter and channel
Click to Show/Hide to Show 10 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP00244  Chloride intracellular channel protein 1 (CLIC1) C24 20.0
 LDTP14222  Chloride intracellular channel protein 4 (CLIC4) C35 20.0
 LDTP11103  Thioredoxin domain-containing protein 17 (TXNDC17) C43 12.1
 LDTP08769  Nuclear pore complex protein Nup93 (NUP93) C522 6.9
 LDTP13661  Sorting nexin-6 (SNX6) C264 5.3
 LDTP04707  Protein SEC13 homolog (SEC13) C187 3.9
 LDTP04801  Gasdermin-D (GSDMD) C268 2.6
 LDTP03327  ATP synthase subunit alpha, mitochondrial (ATP5F1A) C294 1.5
 LDTP05057  Small ribosomal subunit protein RACK1 (RACK1) C182 0.9
 LDTP04259  Signal recognition particle 9 kDa protein (SRP9) C48 0.7
Transcription factor
Click to Show/Hide to Show 3 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP06341  Non-POU domain-containing octamer-binding protein (NONO) C145 1.4
 LDTP01191  Zinc finger protein 217 (ZNF217) C286 1.2
 LDTP07940  eIF5-mimic protein 2 (BZW1) C35 1.0
Other
Click to Show/Hide to Show 44 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP04560  Cytosolic Fe-S cluster assembly factor NUBP1 (NUBP1) C235 20.0
 LDTP13979  Cytosolic iron-sulfur assembly component 2B (CIAO2B) C93 20.0
 LDTP07755  Dynamin-binding protein (DNMBP) C691 20.0
 LDTP04092  Crk-like protein (CRKL) C249 20.0
 LDTP12412  Reticulon-4 (RTN4) C1101 10.9
 LDTP12754  H/ACA ribonucleoprotein complex subunit 2 (NHP2) C18 3.9
 LDTP06082  Dynactin subunit 1 (DCTN1) C1252 2.9
 LDTP04975  Small ribosomal subunit protein uS17 (RPS11) C60 2.8
 LDTP01567  Structural maintenance of chromosomes protein 2 (SMC2) C1174 2.4
 LDTP00202  AH receptor-interacting protein (AIP) C122 2.1
 LDTP04110  Small ribosomal subunit protein uS7 (RPS5) C66 1.9
 LDTP00552  Actin-related protein 2/3 complex subunit 3 (ARPC3) C162 1.9
 LDTP15730  Ataxin-7-like protein 3B (ATXN7L3B) C75 1.8
 LDTP13591  A-kinase anchor protein 8-like (AKAP8L) C211 1.7
 LDTP12780  THUMP domain-containing protein 1 (THUMPD1) C31 1.7
 LDTP03987  Small ribosomal subunit protein eS27 (RPS27) C77 1.7
 LDTP15677  Ribosomal protein eL42-like (RPL36AL) C88 1.6
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C23 1.5
 LDTP03815  Large ribosomal subunit protein uL4 (RPL4) C96 1.5
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C291 1.5
 LDTP10864  Calponin-2 (CNN2) C164 1.4
 LDTP10864  Calponin-2 (CNN2) C215 1.3
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) C267 1.3
 LDTP03665  Cleavage stimulation factor subunit 2 (CSTF2) C150 1.3
 LDTP10781  NudC domain-containing protein 1 (NUDCD1) C376 1.3
 LDTP04390  T-complex protein 1 subunit theta (CCT8) C244 1.2
 LDTP05021  Large ribosomal subunit protein eL30 (RPL30) C92 1.2
 LDTP07947  Eukaryotic translation initiation factor 3 subunit M (EIF3M) C134 1.1
 LDTP13964  MOB-like protein phocein (MOB4) C134 1.1
 LDTP11890  Protein unc-45 homolog A (UNC45A) C426 1.1
 LDTP03395  Large ribosomal subunit protein uL16 (RPL10) C105 1.1
 LDTP03860  Stress-70 protein, mitochondrial (HSPA9) C317 1.1
 LDTP10843  MMS19 nucleotide excision repair protein homolog (MMS19) C848 1.0
 LDTP02205  Tubulin beta chain (TUBB) C239 1.0
 LDTP04971  Small ribosomal subunit protein uS12 (RPS23) C90 1.0
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C194 0.9
 LDTP13817  Nuclear migration protein nudC (NUDC) C188 0.9
 LDTP00756  Heterogeneous nuclear ribonucleoprotein R (HNRNPR) C99 0.8
 LDTP02205  Tubulin beta chain (TUBB) C354 0.8
 LDTP05008  Large ribosomal subunit protein uL14 (RPL23) C28 0.8
 LDTP04997  Small ribosomal subunit protein eS4, X isoform (RPS4X) C41 0.8
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C6 0.8
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C36 0.7
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C109 0.6

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.