Details of the Target

General Information of Target

Target ID LDTP02765
Target Name Aldo-keto reductase family 1 member B1 (AKR1B1)
Gene Name AKR1B1
Gene ID 231
Synonyms
ALDR1; ALR2; Aldo-keto reductase family 1 member B1; EC 1.1.1.300; EC 1.1.1.372; EC 1.1.1.54; Aldehyde reductase; Aldose reductase; AR; EC 1.1.1.21
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQ
EKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGK
EFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKP
AVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAK
HNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCA
LLSCTSHKDYPFHEEF
Target Type
Successful
Target Bioclass
Enzyme
Family
Aldo/keto reductase family
Subcellular location
Cytoplasm
Function
Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia. Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal. Catalyzes the reduction of diverse phospholipid aldehydes such as 1-palmitoyl-2-(5-oxovaleroyl)-sn -glycero-3-phosphoethanolamin (POVPC) and related phospholipid aldehydes that are generated from the oxydation of phosphotidylcholine and phosphatdyleethanolamides. Plays a role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls).
TTD ID
T26623
Uniprot ID
P15121
DrugMap ID
TTFBNVI
Ensemble ID
ENST00000285930.9
HGNC ID
HGNC:381
ChEMBL ID
CHEMBL1900

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 41 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Alkylaryl probe 3
 Probe Info  		7.14  LDD0381  [1]
CY4
 Probe Info  		100.00  LDD0244  [2]
TH211
 Probe Info  		Y210(10.33)  LDD0260  [3]
TH214
 Probe Info  		Y190(5.64)  LDD0258  [3]
YN-1
 Probe Info  		100.00  LDD0444  [4]
ONAyne
 Probe Info  		K235(5.44); K263(7.19)  LDD0274  [5]
BTD
 Probe Info  		C299(5.69)  LDD1699  [6]
OPA-S-S-alkyne
 Probe Info  		K263(8.32)  LDD3494  [7]
AHL-Pu-1
 Probe Info  		C304(2.39)  LDD0168  [8]
EA-probe
 Probe Info  		N.A.  LDD0440  [9]
HHS-475
 Probe Info  		Y83(1.15)  LDD0264  [10]
HHS-465
 Probe Info  		Y104(5.01); Y83(10.00)  LDD2237  [11]
DBIA
 Probe Info  		C299(1.06); C81(0.89); C304(0.88)  LDD0078  [12]
5E-2FA
 Probe Info  		N.A.  LDD2235  [13]
AMP probe
 Probe Info  		N.A.  LDD0200  [14]
ATP probe
 Probe Info  		K263(0.00); K22(0.00); K95(0.00); K90(0.00)  LDD0199  [14]
m-APA
 Probe Info  		N.A.  LDD2231  [13]
4-Iodoacetamidophenylacetylene
 Probe Info  		C45(0.00); C200(0.00); C81(0.00); C299(0.00)  LDD0038  [15]
IA-alkyne
 Probe Info  		C45(0.00); C200(0.00)  LDD0032  [16]
IPIAA_H
 Probe Info  		C45(0.00); C187(0.00)  LDD0030  [17]
IPIAA_L
 Probe Info  		C45(0.00); C187(0.00)  LDD0031  [17]
Lodoacetamide azide
 Probe Info  		C45(0.00); C200(0.00); C81(0.00); C299(0.00)  LDD0037  [15]
ATP probe
 Probe Info  		K240(0.00); K12(0.00)  LDD0035  [18]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [19]
WYneN
 Probe Info  		C304(0.00); C187(0.00)  LDD0021  [20]
WYneO
 Probe Info  		N.A.  LDD0022  [20]
Compound 10
 Probe Info  		N.A.  LDD2216  [21]
IPM
 Probe Info  		N.A.  LDD0005  [20]
NHS
 Probe Info  		K22(0.00); K263(0.00); K12(0.00)  LDD0010  [20]
SF
 Probe Info  		K263(0.00); Y83(0.00); Y49(0.00)  LDD0028  [22]
STPyne
 Probe Info  		K22(0.00); K263(0.00)  LDD0009  [20]
TFBX
 Probe Info  		N.A.  LDD0148  [19]
VSF
 Probe Info  		N.A.  LDD0007  [20]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [23]
1c-yne
 Probe Info  		K12(0.00); K22(0.00)  LDD0228  [24]
1d-yne
 Probe Info  		N.A.  LDD0357  [24]
Acrolein
 Probe Info  		C45(0.00); C187(0.00); C81(0.00); C299(0.00)  LDD0217  [25]
Crotonaldehyde
 Probe Info  		C81(0.00); C200(0.00)  LDD0219  [25]
Methacrolein
 Probe Info  		C45(0.00); C81(0.00); H42(0.00); C200(0.00)  LDD0218  [25]
AOyne
 Probe Info  		15.00  LDD0443  [26]
HHS-482
 Probe Info  		Y210(1.26); Y83(1.46)  LDD2239  [11]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		9.65  LDD0137  [27]
STS-2
 Probe Info  		1.01  LDD0138  [27]
DA-2
 Probe Info  		N.A.  LDD0071  [28]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C299(0.91); C187(0.40); C304(0.40); C45(0.50)  LDD2142  [6]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C299(0.94); C81(0.91); C187(0.62); C304(0.76)  LDD2112  [6]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C299(0.95)  LDD2095  [6]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C299(1.12)  LDD2130  [6]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C299(0.70); C81(1.22); C187(1.41); C304(0.88)  LDD2117  [6]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C299(1.04); C187(1.51); C200(1.22)  LDD2152  [6]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C299(1.31); C187(1.04); C304(1.78)  LDD2103  [6]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C299(1.02); C187(0.45); C304(0.56)  LDD2132  [6]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C299(0.75)  LDD2131  [6]
 LDCM0025  4SU-RNA HEK-293T C304(2.39)  LDD0168  [8]
 LDCM0026  4SU-RNA+native RNA HEK-293T C304(2.06)  LDD0173  [8]
 LDCM0214  AC1 HCT 116 C299(0.65)  LDD0531  [12]
 LDCM0215  AC10 HEK-293T C299(0.83); C81(0.86)  LDD0813  [12]
 LDCM0216  AC100 HCT 116 C299(0.90)  LDD0533  [12]
 LDCM0217  AC101 HCT 116 C299(1.08)  LDD0534  [12]
 LDCM0218  AC102 HCT 116 C299(0.94)  LDD0535  [12]
 LDCM0219  AC103 HCT 116 C299(1.16)  LDD0536  [12]
 LDCM0220  AC104 HCT 116 C299(0.91)  LDD0537  [12]
 LDCM0221  AC105 HCT 116 C299(0.91)  LDD0538  [12]
 LDCM0222  AC106 HCT 116 C299(0.91)  LDD0539  [12]
 LDCM0223  AC107 HCT 116 C299(0.74)  LDD0540  [12]
 LDCM0224  AC108 HCT 116 C299(0.80)  LDD0541  [12]
 LDCM0225  AC109 HCT 116 C299(0.75)  LDD0542  [12]
 LDCM0226  AC11 HEK-293T C299(0.82); C81(1.15)  LDD0824  [12]
 LDCM0227  AC110 HCT 116 C299(0.90)  LDD0544  [12]
 LDCM0228  AC111 HCT 116 C299(0.96)  LDD0545  [12]
 LDCM0229  AC112 HCT 116 C299(0.96)  LDD0546  [12]
 LDCM0230  AC113 HCT 116 C299(0.92)  LDD0547  [12]
 LDCM0231  AC114 HCT 116 C299(0.87)  LDD0548  [12]
 LDCM0232  AC115 HCT 116 C299(0.88)  LDD0549  [12]
 LDCM0233  AC116 HCT 116 C299(0.86)  LDD0550  [12]
 LDCM0234  AC117 HCT 116 C299(0.91)  LDD0551  [12]
 LDCM0235  AC118 HCT 116 C299(0.82)  LDD0552  [12]
 LDCM0236  AC119 HCT 116 C299(0.76)  LDD0553  [12]
 LDCM0237  AC12 HEK-293T C299(0.78); C81(0.94)  LDD0835  [12]
 LDCM0238  AC120 HCT 116 C299(0.94)  LDD0555  [12]
 LDCM0239  AC121 HCT 116 C299(0.75)  LDD0556  [12]
 LDCM0240  AC122 HCT 116 C299(0.69)  LDD0557  [12]
 LDCM0241  AC123 HCT 116 C299(0.89)  LDD0558  [12]
 LDCM0242  AC124 HCT 116 C299(0.83)  LDD0559  [12]
 LDCM0243  AC125 HCT 116 C299(0.75)  LDD0560  [12]
 LDCM0244  AC126 HCT 116 C299(0.73)  LDD0561  [12]
 LDCM0245  AC127 HCT 116 C299(0.72)  LDD0562  [12]
 LDCM0246  AC128 HCT 116 C299(0.97)  LDD0563  [12]
 LDCM0247  AC129 HCT 116 C299(1.17)  LDD0564  [12]
 LDCM0249  AC130 HCT 116 C299(1.15)  LDD0566  [12]
 LDCM0250  AC131 HCT 116 C299(1.16)  LDD0567  [12]
 LDCM0251  AC132 HCT 116 C299(1.00)  LDD0568  [12]
 LDCM0252  AC133 HCT 116 C299(1.13)  LDD0569  [12]
 LDCM0253  AC134 HCT 116 C299(1.31)  LDD0570  [12]
 LDCM0254  AC135 HCT 116 C299(1.11)  LDD0571  [12]
 LDCM0255  AC136 HCT 116 C299(1.16)  LDD0572  [12]
 LDCM0256  AC137 HCT 116 C299(1.09)  LDD0573  [12]
 LDCM0257  AC138 HCT 116 C299(1.54)  LDD0574  [12]
 LDCM0258  AC139 HCT 116 C299(1.34)  LDD0575  [12]
 LDCM0259  AC14 HEK-293T C299(0.94); C81(0.96)  LDD0857  [12]
 LDCM0260  AC140 HCT 116 C299(1.49)  LDD0577  [12]
 LDCM0261  AC141 HCT 116 C299(1.49)  LDD0578  [12]
 LDCM0262  AC142 HCT 116 C299(1.25)  LDD0579  [12]
 LDCM0263  AC143 HCT 116 C299(0.97)  LDD0580  [12]
 LDCM0264  AC144 HCT 116 C299(0.97)  LDD0581  [12]
 LDCM0265  AC145 HCT 116 C299(0.95)  LDD0582  [12]
 LDCM0266  AC146 HCT 116 C299(0.94)  LDD0583  [12]
 LDCM0267  AC147 HCT 116 C299(1.02)  LDD0584  [12]
 LDCM0268  AC148 HCT 116 C299(1.25)  LDD0585  [12]
 LDCM0269  AC149 HCT 116 C299(0.96)  LDD0586  [12]
 LDCM0270  AC15 HEK-293T C299(0.79); C81(0.74)  LDD0868  [12]
 LDCM0271  AC150 HCT 116 C299(0.98)  LDD0588  [12]
 LDCM0272  AC151 HCT 116 C299(0.84)  LDD0589  [12]
 LDCM0273  AC152 HCT 116 C299(1.09)  LDD0590  [12]
 LDCM0274  AC153 HCT 116 C299(1.08)  LDD0591  [12]
 LDCM0621  AC154 HCT 116 C299(1.00)  LDD2158  [12]
 LDCM0622  AC155 HCT 116 C299(0.82)  LDD2159  [12]
 LDCM0623  AC156 HCT 116 C299(0.68)  LDD2160  [12]
 LDCM0624  AC157 HCT 116 C299(1.11)  LDD2161  [12]
 LDCM0276  AC17 HCT 116 C299(0.75)  LDD0593  [12]
 LDCM0277  AC18 HCT 116 C299(0.75)  LDD0594  [12]
 LDCM0278  AC19 HCT 116 C299(0.67)  LDD0595  [12]
 LDCM0279  AC2 HCT 116 C299(0.77)  LDD0596  [12]
 LDCM0280  AC20 HCT 116 C299(0.84)  LDD0597  [12]
 LDCM0281  AC21 HCT 116 C299(0.62)  LDD0598  [12]
 LDCM0282  AC22 HCT 116 C299(0.80)  LDD0599  [12]
 LDCM0283  AC23 HCT 116 C299(0.60)  LDD0600  [12]
 LDCM0284  AC24 HCT 116 C299(0.75)  LDD0601  [12]
 LDCM0285  AC25 HCT 116 C299(0.92)  LDD0602  [12]
 LDCM0286  AC26 HCT 116 C299(0.90)  LDD0603  [12]
 LDCM0287  AC27 HCT 116 C299(0.69)  LDD0604  [12]
 LDCM0288  AC28 HCT 116 C299(0.75)  LDD0605  [12]
 LDCM0289  AC29 HCT 116 C299(0.76)  LDD0606  [12]
 LDCM0290  AC3 HCT 116 C299(0.68)  LDD0607  [12]
 LDCM0291  AC30 HCT 116 C299(0.85)  LDD0608  [12]
 LDCM0292  AC31 HCT 116 C299(0.83)  LDD0609  [12]
 LDCM0293  AC32 HCT 116 C299(1.04)  LDD0610  [12]
 LDCM0294  AC33 HCT 116 C299(0.92)  LDD0611  [12]
 LDCM0295  AC34 HCT 116 C299(0.91)  LDD0612  [12]
 LDCM0296  AC35 HCT 116 C299(0.88)  LDD0613  [12]
 LDCM0297  AC36 HCT 116 C299(1.00)  LDD0614  [12]
 LDCM0298  AC37 HCT 116 C299(0.74)  LDD0615  [12]
 LDCM0299  AC38 HCT 116 C299(0.78)  LDD0616  [12]
 LDCM0300  AC39 HCT 116 C299(0.87)  LDD0617  [12]
 LDCM0301  AC4 HCT 116 C299(0.64)  LDD0618  [12]
 LDCM0302  AC40 HCT 116 C299(0.74)  LDD0619  [12]
 LDCM0303  AC41 HCT 116 C299(0.98)  LDD0620  [12]
 LDCM0304  AC42 HCT 116 C299(0.89)  LDD0621  [12]
 LDCM0305  AC43 HCT 116 C299(0.86)  LDD0622  [12]
 LDCM0306  AC44 HCT 116 C299(1.23)  LDD0623  [12]
 LDCM0307  AC45 HCT 116 C299(0.78)  LDD0624  [12]
 LDCM0308  AC46 HCT 116 C299(0.99)  LDD0625  [12]
 LDCM0309  AC47 HCT 116 C299(0.78)  LDD0626  [12]
 LDCM0310  AC48 HCT 116 C299(0.55)  LDD0627  [12]
 LDCM0311  AC49 HCT 116 C299(0.92)  LDD0628  [12]
 LDCM0312  AC5 HCT 116 C299(0.60)  LDD0629  [12]
 LDCM0313  AC50 HCT 116 C299(1.18)  LDD0630  [12]
 LDCM0314  AC51 HCT 116 C299(0.60)  LDD0631  [12]
 LDCM0315  AC52 HCT 116 C299(1.02)  LDD0632  [12]
 LDCM0316  AC53 HCT 116 C299(1.06)  LDD0633  [12]
 LDCM0317  AC54 HCT 116 C299(1.23)  LDD0634  [12]
 LDCM0318  AC55 HCT 116 C299(1.15)  LDD0635  [12]
 LDCM0319  AC56 HCT 116 C299(1.32)  LDD0636  [12]
 LDCM0320  AC57 HCT 116 C299(0.69)  LDD0637  [12]
 LDCM0321  AC58 HCT 116 C299(0.91)  LDD0638  [12]
 LDCM0322  AC59 HCT 116 C299(0.66)  LDD0639  [12]
 LDCM0323  AC6 HEK-293T C299(0.98); C81(1.19)  LDD0921  [12]
 LDCM0324  AC60 HCT 116 C299(0.73)  LDD0641  [12]
 LDCM0325  AC61 HCT 116 C299(0.77)  LDD0642  [12]
 LDCM0326  AC62 HCT 116 C299(0.69)  LDD0643  [12]
 LDCM0327  AC63 HCT 116 C299(0.70)  LDD0644  [12]
 LDCM0328  AC64 HCT 116 C299(0.67)  LDD0645  [12]
 LDCM0329  AC65 HCT 116 C299(0.82)  LDD0646  [12]
 LDCM0330  AC66 HCT 116 C299(0.76)  LDD0647  [12]
 LDCM0331  AC67 HCT 116 C299(0.77)  LDD0648  [12]
 LDCM0332  AC68 HCT 116 C299(0.87)  LDD0649  [12]
 LDCM0333  AC69 HCT 116 C299(1.12)  LDD0650  [12]
 LDCM0334  AC7 HEK-293T C299(0.96); C81(1.05)  LDD0932  [12]
 LDCM0335  AC70 HCT 116 C299(1.12)  LDD0652  [12]
 LDCM0336  AC71 HCT 116 C299(0.75)  LDD0653  [12]
 LDCM0337  AC72 HCT 116 C299(0.88)  LDD0654  [12]
 LDCM0338  AC73 HCT 116 C299(0.87)  LDD0655  [12]
 LDCM0339  AC74 HCT 116 C299(0.77)  LDD0656  [12]
 LDCM0340  AC75 HCT 116 C299(0.97)  LDD0657  [12]
 LDCM0341  AC76 HCT 116 C299(0.72)  LDD0658  [12]
 LDCM0342  AC77 HCT 116 C299(0.96)  LDD0659  [12]
 LDCM0343  AC78 HCT 116 C299(0.75)  LDD0660  [12]
 LDCM0344  AC79 HCT 116 C299(0.93)  LDD0661  [12]
 LDCM0345  AC8 HEK-293T C299(0.99); C81(0.94)  LDD0943  [12]
 LDCM0346  AC80 HCT 116 C299(0.64)  LDD0663  [12]
 LDCM0347  AC81 HCT 116 C299(0.79)  LDD0664  [12]
 LDCM0348  AC82 HCT 116 C299(0.87)  LDD0665  [12]
 LDCM0349  AC83 HCT 116 C299(0.89)  LDD0666  [12]
 LDCM0350  AC84 HCT 116 C299(0.83)  LDD0667  [12]
 LDCM0351  AC85 HCT 116 C299(0.68)  LDD0668  [12]
 LDCM0352  AC86 HCT 116 C299(0.77)  LDD0669  [12]
 LDCM0353  AC87 HCT 116 C299(0.72)  LDD0670  [12]
 LDCM0354  AC88 HCT 116 C299(0.66)  LDD0671  [12]
 LDCM0355  AC89 HCT 116 C299(0.63)  LDD0672  [12]
 LDCM0357  AC90 HCT 116 C299(0.41)  LDD0674  [12]
 LDCM0358  AC91 HCT 116 C299(0.77)  LDD0675  [12]
 LDCM0359  AC92 HCT 116 C299(0.47)  LDD0676  [12]
 LDCM0360  AC93 HCT 116 C299(0.58)  LDD0677  [12]
 LDCM0361  AC94 HCT 116 C299(0.75)  LDD0678  [12]
 LDCM0362  AC95 HCT 116 C299(0.69)  LDD0679  [12]
 LDCM0363  AC96 HCT 116 C299(0.67)  LDD0680  [12]
 LDCM0364  AC97 HCT 116 C299(0.74)  LDD0681  [12]
 LDCM0365  AC98 HCT 116 C299(1.15)  LDD0682  [12]
 LDCM0366  AC99 HCT 116 C299(1.15)  LDD0683  [12]
 LDCM0545  Acetamide MDA-MB-231 C299(0.73); C304(0.74)  LDD2138  [6]
 LDCM0520  AKOS000195272 MDA-MB-231 C299(0.94); C187(0.55); C304(0.80); C200(1.11)  LDD2113  [6]
 LDCM0248  AKOS034007472 HEK-293T C299(1.15); C81(1.16)  LDD0846  [12]
 LDCM0356  AKOS034007680 HEK-293T C299(0.87); C81(0.96)  LDD0954  [12]
 LDCM0275  AKOS034007705 HEK-293T C299(0.98); C81(1.23)  LDD0873  [12]
 LDCM0020  ARS-1620 HCC44 C299(1.06); C81(0.89); C304(0.88)  LDD0078  [12]
 LDCM0498  BS-3668 MDA-MB-231 C299(1.10); C187(0.88); C304(0.83)  LDD2091  [6]
 LDCM0108  Chloroacetamide HeLa C45(0.00); C187(0.00); C81(0.00); C200(0.00)  LDD0222  [25]
 LDCM0367  CL1 HEK-293T C299(1.08)  LDD0965  [12]
 LDCM0368  CL10 HEK-293T C299(1.04)  LDD0966  [12]
 LDCM0369  CL100 HCT 116 C299(0.64)  LDD0686  [12]
 LDCM0370  CL101 HEK-293T C299(1.15); C81(1.38)  LDD0968  [12]
 LDCM0371  CL102 HEK-293T C299(2.12); C81(1.11)  LDD0969  [12]
 LDCM0372  CL103 HEK-293T C299(1.02); C81(1.01)  LDD0970  [12]
 LDCM0373  CL104 HEK-293T C299(0.92); C81(1.23)  LDD0971  [12]
 LDCM0374  CL105 HCT 116 C299(0.89)  LDD0691  [12]
 LDCM0375  CL106 HCT 116 C299(0.92)  LDD0692  [12]
 LDCM0376  CL107 HCT 116 C299(0.91)  LDD0693  [12]
 LDCM0377  CL108 HCT 116 C299(0.85)  LDD0694  [12]
 LDCM0378  CL109 HCT 116 C299(0.75)  LDD0695  [12]
 LDCM0379  CL11 HEK-293T C299(1.33)  LDD0977  [12]
 LDCM0380  CL110 HCT 116 C299(0.78)  LDD0697  [12]
 LDCM0381  CL111 HCT 116 C299(0.66)  LDD0698  [12]
 LDCM0382  CL112 HCT 116 C299(0.92)  LDD0699  [12]
 LDCM0383  CL113 HCT 116 C299(0.97)  LDD0700  [12]
 LDCM0384  CL114 HCT 116 C299(0.92)  LDD0701  [12]
 LDCM0385  CL115 HCT 116 C299(1.26)  LDD0702  [12]
 LDCM0386  CL116 HCT 116 C299(1.04)  LDD0703  [12]
 LDCM0387  CL117 HCT 116 C299(0.86)  LDD0704  [12]
 LDCM0388  CL118 HCT 116 C299(1.12)  LDD0705  [12]
 LDCM0389  CL119 HCT 116 C299(0.78)  LDD0706  [12]
 LDCM0390  CL12 HEK-293T C299(1.12)  LDD0988  [12]
 LDCM0391  CL120 HCT 116 C299(0.77)  LDD0708  [12]
 LDCM0392  CL121 HCT 116 C299(0.99)  LDD0709  [12]
 LDCM0393  CL122 HCT 116 C299(1.59)  LDD0710  [12]
 LDCM0394  CL123 HCT 116 C299(0.92)  LDD0711  [12]
 LDCM0395  CL124 HCT 116 C299(1.51)  LDD0712  [12]
 LDCM0396  CL125 HCT 116 C299(0.79)  LDD0713  [12]
 LDCM0397  CL126 HCT 116 C299(0.87)  LDD0714  [12]
 LDCM0398  CL127 HCT 116 C299(0.98)  LDD0715  [12]
 LDCM0399  CL128 HCT 116 C299(0.84)  LDD0716  [12]
 LDCM0400  CL13 HEK-293T C299(0.79)  LDD0998  [12]
 LDCM0401  CL14 HEK-293T C299(0.85)  LDD0999  [12]
 LDCM0402  CL15 HEK-293T C299(1.13)  LDD1000  [12]
 LDCM0403  CL16 HCT 116 C299(1.20)  LDD0720  [12]
 LDCM0404  CL17 HCT 116 C299(1.17)  LDD0721  [12]
 LDCM0405  CL18 HCT 116 C299(1.77)  LDD0722  [12]
 LDCM0406  CL19 HCT 116 C299(1.32)  LDD0723  [12]
 LDCM0407  CL2 HEK-293T C299(1.23)  LDD1005  [12]
 LDCM0408  CL20 HCT 116 C299(1.11)  LDD0725  [12]
 LDCM0409  CL21 HCT 116 C299(1.00)  LDD0726  [12]
 LDCM0410  CL22 HCT 116 C299(1.62)  LDD0727  [12]
 LDCM0411  CL23 HCT 116 C299(1.06)  LDD0728  [12]
 LDCM0412  CL24 HCT 116 C299(1.17)  LDD0729  [12]
 LDCM0413  CL25 HCT 116 C299(0.93)  LDD0730  [12]
 LDCM0414  CL26 HCT 116 C299(1.14)  LDD0731  [12]
 LDCM0415  CL27 HCT 116 C299(0.99)  LDD0732  [12]
 LDCM0416  CL28 HCT 116 C299(1.17)  LDD0733  [12]
 LDCM0417  CL29 HCT 116 C299(1.00)  LDD0734  [12]
 LDCM0418  CL3 HEK-293T C299(1.21)  LDD1016  [12]
 LDCM0419  CL30 HCT 116 C299(0.98)  LDD0736  [12]
 LDCM0420  CL31 HCT 116 C299(0.86)  LDD0737  [12]
 LDCM0421  CL32 HCT 116 C299(0.80)  LDD0738  [12]
 LDCM0422  CL33 HCT 116 C299(0.71)  LDD0739  [12]
 LDCM0423  CL34 HCT 116 C299(1.04)  LDD0740  [12]
 LDCM0424  CL35 HCT 116 C299(1.12)  LDD0741  [12]
 LDCM0425  CL36 HCT 116 C299(0.81)  LDD0742  [12]
 LDCM0426  CL37 HCT 116 C299(0.97)  LDD0743  [12]
 LDCM0428  CL39 HCT 116 C299(0.76)  LDD0745  [12]
 LDCM0429  CL4 HEK-293T C299(1.21)  LDD1027  [12]
 LDCM0430  CL40 HCT 116 C299(0.67)  LDD0747  [12]
 LDCM0431  CL41 HCT 116 C299(0.91)  LDD0748  [12]
 LDCM0432  CL42 HCT 116 C299(0.93)  LDD0749  [12]
 LDCM0433  CL43 HCT 116 C299(0.79)  LDD0750  [12]
 LDCM0434  CL44 HCT 116 C299(0.75)  LDD0751  [12]
 LDCM0435  CL45 HCT 116 C299(0.68)  LDD0752  [12]
 LDCM0436  CL46 HCT 116 C299(0.81)  LDD0753  [12]
 LDCM0437  CL47 HCT 116 C299(1.02)  LDD0754  [12]
 LDCM0438  CL48 HCT 116 C299(0.86)  LDD0755  [12]
 LDCM0439  CL49 HCT 116 C299(0.71)  LDD0756  [12]
 LDCM0440  CL5 HEK-293T C299(1.09)  LDD1038  [12]
 LDCM0441  CL50 HCT 116 C299(0.74)  LDD0758  [12]
 LDCM0442  CL51 HCT 116 C299(0.84)  LDD0759  [12]
 LDCM0443  CL52 HCT 116 C299(0.84)  LDD0760  [12]
 LDCM0444  CL53 HCT 116 C299(2.33)  LDD0761  [12]
 LDCM0445  CL54 HCT 116 C299(0.89)  LDD0762  [12]
 LDCM0446  CL55 HCT 116 C299(0.94)  LDD0763  [12]
 LDCM0447  CL56 HCT 116 C299(1.13)  LDD0764  [12]
 LDCM0448  CL57 HCT 116 C299(1.11)  LDD0765  [12]
 LDCM0449  CL58 HCT 116 C299(0.80)  LDD0766  [12]
 LDCM0450  CL59 HCT 116 C299(0.98)  LDD0767  [12]
 LDCM0451  CL6 HEK-293T C299(1.26)  LDD1049  [12]
 LDCM0452  CL60 HCT 116 C299(0.73)  LDD0769  [12]
 LDCM0453  CL61 HCT 116 C299(0.78)  LDD0770  [12]
 LDCM0454  CL62 HCT 116 C299(0.41)  LDD0771  [12]
 LDCM0455  CL63 HCT 116 C299(0.55)  LDD0772  [12]
 LDCM0456  CL64 HCT 116 C299(0.67)  LDD0773  [12]
 LDCM0457  CL65 HCT 116 C299(0.90)  LDD0774  [12]
 LDCM0458  CL66 HCT 116 C299(0.84)  LDD0775  [12]
 LDCM0459  CL67 HCT 116 C299(1.09)  LDD0776  [12]
 LDCM0460  CL68 HCT 116 C299(1.00)  LDD0777  [12]
 LDCM0461  CL69 HCT 116 C299(1.03)  LDD0778  [12]
 LDCM0462  CL7 HEK-293T C299(0.87)  LDD1060  [12]
 LDCM0463  CL70 HCT 116 C299(0.93)  LDD0780  [12]
 LDCM0464  CL71 HCT 116 C299(0.72)  LDD0781  [12]
 LDCM0465  CL72 HCT 116 C299(0.75)  LDD0782  [12]
 LDCM0466  CL73 HCT 116 C299(0.72)  LDD0783  [12]
 LDCM0467  CL74 HCT 116 C299(0.78)  LDD0784  [12]
 LDCM0469  CL76 HCT 116 C299(1.12)  LDD0786  [12]
 LDCM0470  CL77 HCT 116 C299(1.09)  LDD0787  [12]
 LDCM0471  CL78 HCT 116 C299(1.08)  LDD0788  [12]
 LDCM0472  CL79 HCT 116 C299(1.12)  LDD0789  [12]
 LDCM0473  CL8 HEK-293T C299(0.75)  LDD1071  [12]
 LDCM0474  CL80 HCT 116 C299(1.26)  LDD0791  [12]
 LDCM0475  CL81 HCT 116 C299(0.92)  LDD0792  [12]
 LDCM0476  CL82 HCT 116 C299(0.99)  LDD0793  [12]
 LDCM0477  CL83 HCT 116 C299(1.05)  LDD0794  [12]
 LDCM0478  CL84 HCT 116 C299(1.23)  LDD0795  [12]
 LDCM0479  CL85 HCT 116 C299(1.21)  LDD0796  [12]
 LDCM0480  CL86 HCT 116 C299(1.10)  LDD0797  [12]
 LDCM0481  CL87 HCT 116 C299(1.03)  LDD0798  [12]
 LDCM0482  CL88 HCT 116 C299(0.93)  LDD0799  [12]
 LDCM0483  CL89 HCT 116 C299(1.55)  LDD0800  [12]
 LDCM0484  CL9 HEK-293T C299(1.00)  LDD1082  [12]
 LDCM0485  CL90 HCT 116 C299(1.31)  LDD0802  [12]
 LDCM0486  CL91 HCT 116 C299(1.18)  LDD0803  [12]
 LDCM0487  CL92 HCT 116 C299(1.25)  LDD0804  [12]
 LDCM0488  CL93 HCT 116 C299(0.97)  LDD0805  [12]
 LDCM0489  CL94 HCT 116 C299(1.21)  LDD0806  [12]
 LDCM0490  CL95 HCT 116 C299(1.34)  LDD0807  [12]
 LDCM0491  CL96 HCT 116 C299(1.07)  LDD0808  [12]
 LDCM0492  CL97 HCT 116 C299(0.81)  LDD0809  [12]
 LDCM0493  CL98 HCT 116 C299(0.69)  LDD0810  [12]
 LDCM0494  CL99 HCT 116 C299(0.62)  LDD0811  [12]
 LDCM0495  E2913 HEK-293T C187(0.77); C200(0.76); C45(1.04); C299(1.01)  LDD1698  [29]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C304(2.59); C299(0.97)  LDD1702  [6]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [9]
 LDCM0201  EV-3 T cell C299, C304(4.52)  LDD0528  [30]
 LDCM0625  F8 Ramos C81(1.06); C187(1.07); 1.32; C299(2.96)  LDD2187  [31]
 LDCM0572  Fragment10 MDA-MB-231 C299(20.00)  LDD1389  [32]
 LDCM0573  Fragment11 MDA-MB-231 C299(1.67)  LDD1391  [32]
 LDCM0574  Fragment12 MDA-MB-231 C299(1.47)  LDD1393  [32]
 LDCM0575  Fragment13 MDA-MB-231 C299(0.90)  LDD1395  [32]
 LDCM0576  Fragment14 MDA-MB-231 C299(1.15)  LDD1397  [32]
 LDCM0577  Fragment15 MDA-MB-231 C299(0.74)  LDD1399  [32]
 LDCM0579  Fragment20 MDA-MB-231 C299(1.41)  LDD1402  [32]
 LDCM0580  Fragment21 MDA-MB-231 C299(1.12)  LDD1404  [32]
 LDCM0581  Fragment22 MDA-MB-231 C299(1.13)  LDD1406  [32]
 LDCM0582  Fragment23 MDA-MB-231 C299(3.10)  LDD1408  [32]
 LDCM0583  Fragment24 Ramos C299(1.30)  LDD1410  [32]
 LDCM0584  Fragment25 MDA-MB-231 C299(1.31)  LDD1411  [32]
 LDCM0585  Fragment26 Ramos C299(0.85)  LDD1412  [32]
 LDCM0578  Fragment27 MDA-MB-231 C299(0.99)  LDD1401  [32]
 LDCM0586  Fragment28 MDA-MB-231 C299(0.94)  LDD1415  [32]
 LDCM0587  Fragment29 MDA-MB-231 C299(1.16)  LDD1417  [32]
 LDCM0588  Fragment30 MDA-MB-231 C299(1.08)  LDD1419  [32]
 LDCM0589  Fragment31 MDA-MB-231 C299(3.68)  LDD1421  [32]
 LDCM0590  Fragment32 MDA-MB-231 C299(1.38)  LDD1423  [32]
 LDCM0468  Fragment33 HCT 116 C299(1.24)  LDD0785  [12]
 LDCM0592  Fragment34 MDA-MB-231 C299(0.82)  LDD1427  [32]
 LDCM0593  Fragment35 MDA-MB-231 C299(1.12)  LDD1429  [32]
 LDCM0594  Fragment36 MDA-MB-231 C299(2.37)  LDD1431  [32]
 LDCM0596  Fragment38 MDA-MB-231 C299(1.13)  LDD1433  [32]
 LDCM0597  Fragment39 MDA-MB-231 C299(1.52)  LDD1435  [32]
 LDCM0566  Fragment4 MDA-MB-231 C299(1.18)  LDD1378  [32]
 LDCM0598  Fragment40 MDA-MB-231 C299(0.78)  LDD1436  [32]
 LDCM0599  Fragment41 MDA-MB-231 C299(3.72)  LDD1438  [32]
 LDCM0600  Fragment42 Ramos C299(1.05)  LDD1440  [32]
 LDCM0601  Fragment43 MDA-MB-231 C299(1.02)  LDD1441  [32]
 LDCM0602  Fragment44 MDA-MB-231 C299(0.70)  LDD1443  [32]
 LDCM0603  Fragment45 MDA-MB-231 C299(2.11)  LDD1444  [32]
 LDCM0604  Fragment46 MDA-MB-231 C299(0.99)  LDD1445  [32]
 LDCM0605  Fragment47 MDA-MB-231 C299(1.10)  LDD1446  [32]
 LDCM0606  Fragment48 MDA-MB-231 C299(1.06)  LDD1447  [32]
 LDCM0607  Fragment49 MDA-MB-231 C299(2.38)  LDD1448  [32]
 LDCM0608  Fragment50 MDA-MB-231 C299(1.07)  LDD1449  [32]
 LDCM0427  Fragment51 HCT 116 C299(1.13)  LDD0744  [12]
 LDCM0610  Fragment52 MDA-MB-231 C299(1.28)  LDD1452  [32]
 LDCM0611  Fragment53 MDA-MB-231 C299(0.90)  LDD1454  [32]
 LDCM0613  Fragment55 MDA-MB-231 C299(2.45)  LDD1457  [32]
 LDCM0614  Fragment56 MDA-MB-231 C299(1.04)  LDD1458  [32]
 LDCM0568  Fragment6 MDA-MB-231 C299(1.28)  LDD1382  [32]
 LDCM0569  Fragment7 MDA-MB-231 C299(1.54)  LDD1383  [32]
 LDCM0570  Fragment8 MDA-MB-231 C299(1.28)  LDD1385  [32]
 LDCM0571  Fragment9 MDA-MB-231 C299(1.08)  LDD1387  [32]
 LDCM0116  HHS-0101 DM93 Y83(1.15)  LDD0264  [10]
 LDCM0117  HHS-0201 DM93 Y83(1.04)  LDD0265  [10]
 LDCM0118  HHS-0301 DM93 Y83(0.46)  LDD0266  [10]
 LDCM0119  HHS-0401 DM93 Y83(1.24)  LDD0267  [10]
 LDCM0120  HHS-0701 DM93 Y83(0.67)  LDD0268  [10]
 LDCM0107  IAA HeLa C45(0.00); C187(0.00); C81(0.00); C304(0.00)  LDD0221  [25]
 LDCM0022  KB02 HCT 116 C299(2.50); C304(2.50)  LDD0080  [12]
 LDCM0023  KB03 HCT 116 C299(2.26); C304(2.26)  LDD0081  [12]
 LDCM0024  KB05 HCT 116 C299(2.80); C304(2.80)  LDD0082  [12]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C299(1.68); C187(0.77); C304(1.46)  LDD2102  [6]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C299(0.91)  LDD2121  [6]
 LDCM0109  NEM HeLa C200(0.00); C81(0.00); H84(0.00); C45(0.00)  LDD0223  [25]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C299(1.52); C187(1.13); C304(1.07)  LDD2089  [6]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C299(1.19); C81(1.03); C187(1.06); C304(1.05)  LDD2090  [6]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C299(1.13)  LDD2092  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C299(1.65); C187(1.05); C304(1.28); C200(1.24)  LDD2093  [6]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C299(1.14); C187(2.06); C304(2.81)  LDD2094  [6]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C299(0.62); C81(1.29); C187(0.39)  LDD2096  [6]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C299(1.09); C81(0.97); C187(0.85); C304(1.21)  LDD2097  [6]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C299(1.94); C304(0.95); C45(0.84)  LDD2098  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C299(1.01); C187(1.35); C304(1.39); C200(1.25)  LDD2099  [6]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C299(1.77); C81(0.61); C187(0.55); C304(0.92)  LDD2100  [6]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C299(0.73); C187(0.56); C304(1.41); C200(0.96)  LDD2101  [6]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C299(0.99); C81(0.60); C304(0.67); C200(0.67)  LDD2104  [6]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C299(2.20); C45(1.24)  LDD2105  [6]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C299(0.61); C187(0.40); C200(0.68)  LDD2106  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C299(1.01); C187(1.23); C304(1.10); C200(0.99)  LDD2107  [6]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C299(0.93); C187(0.67); C304(0.37); C45(0.52)  LDD2108  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C299(1.30); C81(0.74); C187(0.72); C304(0.65)  LDD2109  [6]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C299(1.47); C187(0.49); C304(0.96); C45(1.46)  LDD2110  [6]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C299(1.02); C187(1.05); C304(1.44)  LDD2111  [6]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C299(0.65); C81(0.82); C187(0.60); C45(1.05)  LDD2114  [6]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C299(0.59); C81(0.78); C304(0.51)  LDD2115  [6]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C299(1.13); C187(0.60); C304(0.16)  LDD2116  [6]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C299(1.26); C187(0.90); C304(0.27)  LDD2118  [6]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C299(1.50); C81(1.16); C187(1.49); C304(1.63)  LDD2119  [6]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C299(0.51); C81(0.46); C187(0.61); C304(0.56)  LDD2120  [6]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C299(1.56); C81(1.18); C187(0.48); C304(0.19)  LDD2122  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C299(1.14); C187(0.97); C304(0.67); C200(0.82)  LDD2123  [6]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C299(1.46); C187(0.51); C304(0.13)  LDD2124  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C299(0.88); C81(1.51); C187(1.00); C304(0.80)  LDD2125  [6]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C299(1.34); C187(0.58)  LDD2126  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C299(0.66); C81(1.54); C187(1.17); C304(0.89)  LDD2127  [6]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C299(0.75); C81(0.63); C187(0.66); C304(1.12)  LDD2128  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C299(0.81); C81(1.54); C187(1.13); C304(1.09)  LDD2129  [6]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C187(0.40); C304(0.66); C200(0.65)  LDD2133  [6]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C299(0.64); C81(0.54); C187(0.50); C200(0.46)  LDD2134  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C299(0.80); C81(1.97); C187(1.05); C304(0.88)  LDD2135  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C299(2.16); C81(1.29); C304(1.39)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C299(0.86); C81(1.14); C187(0.91); C304(0.94)  LDD2137  [6]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C304(1.86); C299(1.22)  LDD1700  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C81(1.39); C187(1.09); C304(1.00)  LDD2140  [6]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C299(0.88); C81(0.65); C187(0.39); C304(0.41)  LDD2141  [6]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C299(0.64); C187(0.61); C304(0.72); C200(0.74)  LDD2143  [6]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C299(1.58); C81(1.30); C187(1.89); C304(1.70)  LDD2144  [6]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C299(11.87); C81(0.36); C187(0.31)  LDD2145  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C299(1.20); C187(1.01); C304(0.94)  LDD2146  [6]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C299(1.11); C81(0.68); C187(1.79); C304(1.62)  LDD2147  [6]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C299(0.57); C81(1.05); C187(0.51); C304(0.57)  LDD2148  [6]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C299(1.21); C187(0.55); C304(0.13)  LDD2149  [6]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C299(1.40); C187(0.89)  LDD2150  [6]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C299(1.65); C187(0.39); C304(0.09)  LDD2151  [6]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C187(2.09); C45(2.63)  LDD2153  [6]
 LDCM0627  NUDT7-COV-1 HEK-293T C299(0.81)  LDD2206  [33]
 LDCM0628  OTUB2-COV-1 HEK-293T C299(0.84)  LDD2207  [33]
 LDCM0131  RA190 MM1.R C299(1.20)  LDD0304  [34]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
EF-hand calcium-binding domain-containing protein 11 (EFCAB11) . Q9BUY7

The Drug(s) Related To This Target

Approved
Click To Hide/Show 8 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Citric Acid Small molecular drug DB04272
Daunorubicin Small molecular drug DB00694
Epalrestat Small molecular drug D03KOZ
Fenofibrate Small molecular drug DB01039
Glutathione Small molecular drug DB00143
Lumateperone Small molecular drug DB06077
Nadh Small molecular drug DB00157
Sulindac Small molecular drug D0Z5IU
Phase 3
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Contigoside B Small molecular drug D04PBH
Fidarestat Small molecular drug D00EWR
Ranirestat Small molecular drug D0K8TI
Phase 2
Click To Hide/Show 5 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Lidorestat Small molecular drug D04BFU
M-16209 Small molecular drug D0V4UO
Admva Vaccine D0P7SO
Qr-333 . D0B4XX
T2c-003 . D00QKL
Phase 1
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Alo-1567 Small molecular drug D07DIX
Ssr-125047 Small molecular drug D0Q7QY
Preclinical
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ari-809 Small molecular drug D0M9RE
Investigative
Click To Hide/Show 93 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
(4-methyl-2-oxo-2h-quinolin-1-yl)-acetic Acid Small molecular drug D0IF8Z
(6-hydroxy-2-oxo-2h-quinolin-1-yl)-acetic Acid Small molecular drug D0F6TM
(6-methoxy-2-oxo-2h-quinolin-1-yl)-acetic Acid Small molecular drug D0J7MD
(8-hydroxy-2-oxo-2h-quinolin-1-yl)-acetic Acid Small molecular drug D07GTX
(Sr)-fidarestat Small molecular drug DB02101
2'-monophosphoadenosine 5'-diphosphoribose Small molecular drug D0J2FY
2,3-dihydroxypropanal Small molecular drug D09PNQ
2-(3,4-dihydroxy-benzyl)-7-hydroxy-chromen-4-one Small molecular drug D0A9NE
2-(3,4-dihydroxy-phenyl)-7-hydroxy-chromen-4-one Small molecular drug D0YJ3Q
2-(3-benzoyl-1h-pyrrol-1-yl)Acetic Acid Small molecular drug D03LRQ
2-(4-aminophenylsulfonamido)Acetic Acid Small molecular drug D01UNC
2-(Phenylsulfonamido)Acetic Acid Small molecular drug D04YIV
2-benzhydryl-7-hydroxy-chromen-4-one Small molecular drug D04GYD
2-benzyl-7-hydroxy-chromen-4-one Small molecular drug D0QP9D
3,5-dichlorosalicylic Acid Small molecular drug D06SPO
3-(3-benzoyl-1h-pyrrol-1-yl)Propanoic Acid Small molecular drug D0CX4E
3-[5-(3-nitrophenyl)Thiophen-2-yl]Propanoic Acid Small molecular drug D0T2TW
4-(3-benzoyl-1h-pyrrol-1-yl)Butanoic Acid Small molecular drug D0G4CJ
4-(3-methoxy-phenyl)-isoxazolidine-3,5-dione Small molecular drug D08ZZX
6,7-dihydroxy-2-phenyl-chromen-4-one Small molecular drug D05HBF
6-(1h-indole-2-sulfonyl)-2h-pyridazin-3-one Small molecular drug D0A2FM
6-(2-bromo-benzenesulfonyl)-2h-pyridazin-3-one Small molecular drug D0O9KV
6-(2-chloro-benzenesulfonyl)-2h-pyridazin-3-one Small molecular drug D00EPD
6-(2-fluoro-benzenesulfonyl)-2h-pyridazin-3-one Small molecular drug D06YQS
6-(3-chloro-benzenesulfonyl)-2h-pyridazin-3-one Small molecular drug D0R7IJ
6-(4-bromo-benzenesulfonyl)-2h-pyridazin-3-one Small molecular drug D0Y7PW
6-(4-chloro-benzenesulfonyl)-2h-pyridazin-3-one Small molecular drug D02AAH
6-(4-fluoro-benzenesulfonyl)-2h-pyridazin-3-one Small molecular drug D0XD1Q
6-(4-methoxy-benzenesulfonyl)-2h-pyridazin-3-one Small molecular drug D0P3AU
6-(Benzofuran-2-sulfonyl)-2h-pyridazin-3-one Small molecular drug D0R3MB
6-(Benzothiazole-2-sulfonyl)-2h-pyridazin-3-one Small molecular drug D02WZA
6-(Biphenyl-2-sulfonyl)-2h-pyridazin-3-one Small molecular drug D07XXK
6-(Naphthalene-1-sulfonyl)-2h-pyridazin-3-one Small molecular drug D0P1ZM
6-(Naphthalene-2-sulfonyl)-2h-pyridazin-3-one Small molecular drug D08JEI
6-(Toluene-4-sulfonyl)-2h-pyridazin-3-one Small molecular drug D0IB8C
6-benzenesulfonyl-2h-pyridazin-3-one Small molecular drug D0OZ4C
6-hydroxy-2-(4-hydroxy-benzyl)-chromen-4-one Small molecular drug D08MHU
6-methoxykaempferol 3-o-beta-d-robinobioside Small molecular drug D03NEF
6-phenylmethanesulfonyl-2h-pyridazin-3-one Small molecular drug D03YBR
7-hydroxy-2-(4-hydroxy-benzyl)-chromen-4-one Small molecular drug D00WFB
7-hydroxy-2-(4-methoxy-benzyl)-chromen-4-one Small molecular drug D05SLZ
7-hydroxy-4-phenylcoumarin Small molecular drug D0OC4B
7-hydroxy-6-nitro-2-phenyl-chromen-4-one Small molecular drug D0L7MI
Ak198 Small molecular drug D0K8NO
Alpha-d-glucose 6-phosphate Small molecular drug DB02007
Alpha-d-glucose-6-phosphate Small molecular drug D01AWD
Apigenin Small molecular drug D00RIX
Apigenin-7-o-beta-d-glucuronide Small molecular drug D01LWJ
Apigenin-7-o-beta-d-glucuronide Methyl Ester Small molecular drug D0BH6B
Astragalin Small molecular drug D08BFU
Cacodylic Acid Small molecular drug DB02994
Chrysin Small molecular drug D01UYI
Cp-744809 Small molecular drug DB07187
Daidzein Small molecular drug D0SY2M
Epalrestate Small molecular drug D0A4LM
Exisulind Small molecular drug DB06246
Fidarestat(Stereoisomer) Small molecular drug D00KCB
Hydroxydimethylarsine Oxide Small molecular drug D06YEV
Idd552 Small molecular drug D07JEY
Idd594 Small molecular drug D0FJ7G
Inhibitor Idd 384 Small molecular drug D00VHG
Isorhamnetin 3,7-disulfate Small molecular drug D08NKL
Isorhamnetin 3-o-rhamnoside Small molecular drug D0J7VA
Kaempferol Small molecular drug D0G3TK
Lidorestat Small molecular drug DB07063
Mangiferin Small molecular drug D04UYB
N-acetylalanine Small molecular drug D09MYF
Nsc-94258 Small molecular drug D01KKU
O5-acetyl-o7-nitrooxyethyl Chrysin Small molecular drug D08OYH
O7-nitrooxyethyl Chrysin Small molecular drug D01KAM
Palbinone Small molecular drug D03DEO
Patuletin 3-o-beta-d-galactoside Small molecular drug D0Z3FX
Patuletin 3-o-beta-d-robinobioside Small molecular drug D08DRD
Pimagedine Small molecular drug DB05383
Quercetin 3-o-neohesperidoside Small molecular drug D0G1OW
Quercitrin Small molecular drug D07DJS
Tamarixetin 3-glucoside-7-sulfate Small molecular drug D0U8GZ
Tingenin B Small molecular drug D0BU5K
Tingenone Small molecular drug D0F6AI
Triptocalline A Small molecular drug D02DYB
Zopolrestat Small molecular drug DB08772
(2-{[(4-bromo-2-fluorobenzyl)Amino]Carbonyl}-5-chlorophenoxy)Acetic Acid . DB07028
(5-chloro-2-{[(3-nitrobenzyl)Amino]Carbonyl}Phenoxy)Acetic Acid . DB07030
(R)-minalrestat . DB07450
2-(3-((457-trifluorobenzo[D]Thiazol-2-yl)Methyl)-1h-pyrrolo[23-b]Pyridin-1-yl)Acetic Acid . DB08449
2-(Carboxymethyl)-1-oxo-12-dihydronaphtho[12-d]Isothiazole-4-carboxylic Acid 33-dioxide . DB08000
4-[3-(3-nitrophenyl)-124-oxadiazol-5-yl]Butanoic Acid . DB07498
Bnv-222 . D0R3OQ
Gavorestat . DB16707
Nicotinamide Adenine Dinucleotide Phosphate . DB03461
{3-[(5-chloro-13-benzothiazol-2-yl)Methyl]-24-dioxo-34-dihydropyrimidin-1(2h)-yl}Acetic Acid . DB07093
{4-[(Carboxymethoxy)Carbonyl]-33-dioxido-1-oxonaphtho[12-d]Isothiazol-2(1h)-yl}Acetic Acid . DB07999
{[5-(5-nitro-2-furyl)-134-oxadiazol-2-yl]Thio}Acetic Acid . DB08098
Discontinued
Click To Hide/Show 15 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ad-5467 Small molecular drug D0O2ET
Alrestatin Small molecular drug D03PIB
E-0722 Small molecular drug D0B0GC
Fr-62765 Small molecular drug D0RZ0N
Imirestat Small molecular drug D0Q7AW
Minalrestat Small molecular drug D0J6JZ
Ponalrestat Small molecular drug D0U9TM
Sorbinil Small molecular drug D02CGC
Spr-210 Small molecular drug D0E6LC
Tolrestat Small molecular drug DB02383
Wf-2421 Small molecular drug D09BHF
Zenarestat Small molecular drug D0C7KK
Zopolrestat Small molecular drug D06EDT
Ctl-102-gdept . D0E0FY
Jtt-811 . D08VMO

References

1 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
8 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
9 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
10 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
11 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
12 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
13 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
14 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
15 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
16 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
17 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
18 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
19 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
20 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
21 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
22 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
23 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
24 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
25 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
26 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
27 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
28 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
29 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
30 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
31 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
32 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
33 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
34 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.