Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name AHL-Pu-1  Probe Info 
Probe concentration 25 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
SILAC
Competitor Name 4SU-RNA+native RNA  Competitor Info 
Competitor Concentration 250 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cell lysate (HEK-293T)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 77 Protein Related to This Bioclass
Target ID Target Name Binding Sites
 LDTP06150  DNA replication licensing factor MCM6 (MCM6) C242
 LDTP11300  tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial (TRMT61B) C67
 LDTP03481  DNA-3-methyladenine glycosylase (MPG) C56
 LDTP04090  Transcriptional regulator ATRX (ATRX) C1718
 LDTP03308  Beta-adrenergic receptor kinase 1 (GRK2) C120
 LDTP05136  DNA-dependent protein kinase catalytic subunit (PRKDC) C2342
 LDTP11266  tRNA (guanine(6)-N2)-methyltransferase THUMP3 (THUMPD3) C391
 LDTP10318  Ubiquitin thioesterase OTUB1 (OTUB1) C91
 LDTP03350  DNA (cytosine-5)-methyltransferase 1 (DNMT1) C751
 LDTP06919  FAST kinase domain-containing protein 1, mitochondrial (FASTKD1) C446
 LDTP05071  Elongation factor 1-alpha 1 (EEF1A1) C234
 LDTP15029  Putative elongation factor 1-alpha-like 3 (EEF1A1P5) C234
 LDTP00982  Long-chain-fatty-acid--CoA ligase 4 (ACSL4) C602
 LDTP02474  Ras-related protein Rap-2a (RAP2A) C140
 LDTP12415  Adenosine 5'-monophosphoramidase HINT3 (HINT3) C32
 LDTP04210  Casein kinase I isoform delta (CSNK1D) C241
 LDTP04275  Casein kinase I isoform epsilon (CSNK1E) C241
 LDTP05422  Copper-transporting ATPase 1 (ATP7A) C388
 LDTP05698  TNF receptor-associated factor 2 (TRAF2) C124
 LDTP04440  Peroxisomal multifunctional enzyme type 2 (HSD17B4) C277
 LDTP05136  DNA-dependent protein kinase catalytic subunit (PRKDC) C1399
 LDTP14264  Choline/ethanolaminephosphotransferase 1 (CEPT1) C11
 LDTP04509  Dual specificity mitogen-activated protein kinase kinase 6 (MAP2K6) C216
 LDTP15359  Probable tRNA (uracil-O(2)-)-methyltransferase (TRMT44) C194
 LDTP05475  Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) C333
 LDTP00714  26S proteasome non-ATPase regulatory subunit 3 (PSMD3) C483
 LDTP14264  Choline/ethanolaminephosphotransferase 1 (CEPT1) C30
 LDTP07980  OTU domain-containing protein 6A (OTUD6A) C152
 LDTP05136  DNA-dependent protein kinase catalytic subunit (PRKDC) C3403
 LDTP04317  NADH dehydrogenase flavoprotein 1, mitochondrial (NDUFV1) C238
 LDTP06279  Septin-2 (SEPTIN2) C111
 LDTP11996  3'-5' RNA helicase YTHDC2 (YTHDC2) C460
 LDTP03564  DNA-directed RNA polymerase II subunit RPB2 (POLR2B) C510
 LDTP01768  Glutamate dehydrogenase 1, mitochondrial (GLUD1) C327
 LDTP04256  Glutamate dehydrogenase 2, mitochondrial (GLUD2) C327
 LDTP05841  Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PPP2R5C) C513
 LDTP14723  Selenocysteine-specific elongation factor (EEFSEC) C93
 LDTP11971  tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial (NSUN3) C49
 LDTP03726  Replication factor C subunit 2 (RFC2) C171
 LDTP08436  Interferon regulatory factor 2-binding protein 1 (IRF2BP1) C363
 LDTP02225  Heat shock protein HSP 90-alpha (HSP90AA1) C598
 LDTP02860  Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) C560
 LDTP02848  NADPH--cytochrome P450 reductase (POR) C363
 LDTP15505  Choline dehydrogenase, mitochondrial (CHDH) C242
 LDTP11054  Zinc phosphodiesterase ELAC protein 2 (ELAC2) C753
 LDTP17488  Putative glycerol kinase 5 (GK5) C390
 LDTP06188  Ribosome biogenesis protein BMS1 homolog (BMS1) C556
 LDTP08728  Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) C50
 LDTP01636  DNA-directed RNA polymerase I subunit RPA1 (POLR1A) C1304
 LDTP03159  Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) C350
 LDTP17587  Catechol O-methyltransferase domain-containing protein 1 (COMTD1) C45
 LDTP05136  DNA-dependent protein kinase catalytic subunit (PRKDC) C2093
 LDTP04286  DNA replication licensing factor MCM2 (MCM2) C522
 LDTP03540  Heme oxygenase 2 (HMOX2) C282
 LDTP10649  28S rRNA (cytosine-C(5))-methyltransferase (NSUN5) C308
 LDTP04547  Nuclear pore complex protein Nup98-Nup96 (NUP98) C1464
 LDTP13885  Lysine-specific demethylase 2A (KDM2A) C840
 LDTP04103  Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3) C227
 LDTP04547  Nuclear pore complex protein Nup98-Nup96 (NUP98) C1476
 LDTP03540  Heme oxygenase 2 (HMOX2) C265
 LDTP11297  Guanine nucleotide-binding protein-like 3 (GNL3) C15
 LDTP05136  DNA-dependent protein kinase catalytic subunit (PRKDC) C1629
 LDTP04671  Trifunctional enzyme subunit beta, mitochondrial (HADHB) C458
 LDTP07101  Putative methyltransferase C9orf114 (SPOUT1) C10
 LDTP04211  Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) C402
 LDTP15517  Cytosolic endo-beta-N-acetylglucosaminidase (ENGASE) C414
 LDTP00408  Histone-lysine N-methyltransferase 2D (KMT2D) C1948
 LDTP12608  Phosphatidylinositol-3-phosphatase SAC1 (SACM1L) C445
 LDTP08942  Deubiquitinase OTUD6B (OTUD6B) C172
 LDTP06173  E3 ubiquitin-protein ligase TRIP12 (TRIP12) C332
 LDTP10982  Aconitate hydratase, mitochondrial (ACO2) C385
 LDTP02765  Aldo-keto reductase family 1 member B1 (AKR1B1) C304
 LDTP06185  Disco-interacting protein 2 homolog A (DIP2A) C6
 LDTP07910  E3 ubiquitin-protein ligase Hakai (CBLL1) C73
 LDTP05422  Copper-transporting ATPase 1 (ATP7A) C391
 LDTP00464  Glutathione S-transferase 3, mitochondrial (MGST3) C56
 LDTP07559  Long-chain fatty acid transport protein 1 (SLC27A1) C394
Transporter and channel
Click to Show/Hide to Show 9 Protein Related to This Bioclass
Target ID Target Name Binding Sites
 LDTP04309  Nuclear pore complex protein Nup153 (NUP153) C68
 LDTP09279  THO complex subunit 2 (THOC2) C743
 LDTP12142  Exportin-5 (XPO5) C714
 LDTP04501  Importin subunit alpha-1 (KPNA2) C223
 LDTP04391  T-complex protein 1 subunit delta (CCT4) C120
 LDTP09742  Protein ELYS (AHCTF1) C722
 LDTP09987  Secretory carrier-associated membrane protein 4 (SCAMP4) C20
 LDTP16241  Transmembrane and coiled-coil domain protein 3 (TMCC3) C180
 LDTP13018  Stromal interaction molecule 2 (STIM2) C698
Transcription factor
Click to Show/Hide to Show 25 Protein Related to This Bioclass
Target ID Target Name Binding Sites
 LDTP05759  RE1-silencing transcription factor (REST) C415
 LDTP05654  Alpha-globin transcription factor CP2 (TFCP2) C453
 LDTP13360  Methyl-CpG-binding domain protein 1 (MBD1) C57
 LDTP14540  Zinc finger and BTB domain-containing protein 11 (ZBTB11) C197
 LDTP15497  Zinc finger protein 280C (ZNF280C) C734
 LDTP19380  Zinc finger MYM-type protein 1 (ZMYM1) C35
 LDTP11947  Zinc finger protein 644 (ZNF644) C1077
 LDTP17346  Zinc finger protein 770 (ZNF770) C369
 LDTP14809  CCAAT/enhancer-binding protein zeta (CEBPZ) C374
 LDTP05101  General transcription factor II-I (GTF2I) C475
 LDTP15414  Ligand-dependent nuclear receptor corepressor-like protein (LCORL) C130
 LDTP10379  Tonsoku-like protein (TONSL) C283
 LDTP06040  Vascular endothelial zinc finger 1 (VEZF1) C319
 LDTP03903  Signal transducer and activator of transcription 3 (STAT3) C251
 LDTP10839  Msx2-interacting protein (SPEN) C3632
 LDTP03280  COUP transcription factor 2 (NR2F2) C200
 LDTP15497  Zinc finger protein 280C (ZNF280C) C22
 LDTP07454  Zinc finger protein 280D (ZNF280D) C21
 LDTP02897  Nucleolar transcription factor 1 (UBTF) C309
 LDTP08093  Retinoic acid-induced protein 1 (RAI1) C649
 LDTP16956  Zinc finger protein 14 (ZNF14) C262
 LDTP10839  Msx2-interacting protein (SPEN) C1066
 LDTP10926  Homeobox protein CDX-2 (CDX2) C166
 LDTP07412  Protein Jade-1 (JADE1) C546
 LDTP05760  Zinc finger protein Rlf (RLF) C78
GPCR
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Sites
 LDTP04339  Type-2 angiotensin II receptor (AGTR2) C195
Immunoglobulin
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Sites
 LDTP02040  HLA class I histocompatibility antigen, A alpha chain (HLA-A) C125
Cytokine and receptor
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Sites
 LDTP05757  Protein Red (IK) C448
Other
Click to Show/Hide to Show 67 Protein Related to This Bioclass
Target ID Target Name Binding Sites
 LDTP05525  KH domain-containing, RNA-binding, signal transduction-associated protein 1 (KHDRBS1) C264
 LDTP12518  Bromodomain adjacent to zinc finger domain protein 1A (BAZ1A) C764
 LDTP02656  Ribonuclease inhibitor (RNH1) C159
 LDTP10419  Biorientation of chromosomes in cell division protein 1 (BOD1) C72
 LDTP09196  Biorientation of chromosomes in cell division protein 1-like 1 (BOD1L1) C74
 LDTP10831  Remodeling and spacing factor 1 (RSF1) C650
 LDTP01961  Alpha-2-HS-glycoprotein (AHSG) C132
 LDTP09363  TBC1 domain family member 15 (TBC1D15) C24
 LDTP04117  Ras GTPase-activating-like protein IQGAP1 (IQGAP1) C1534
 LDTP05259  Heterogeneous nuclear ribonucleoprotein U (HNRNPU) C408
 LDTP08713  WD repeat and FYVE domain-containing protein 3 (WDFY3) C1600
 LDTP03574  Rab GDP dissociation inhibitor alpha (GDI1) C282
 LDTP16846  Ribosome biogenesis protein NSA2 homolog (NSA2) C154
 LDTP17757  Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) C361
 LDTP06979  BCL-6 corepressor-like protein 1 (BCORL1) C679
 LDTP12875  Podocalyxin-like protein 2 (PODXL2) C487
 LDTP11192  Death-inducer obliterator 1 (DIDO1) C976
 LDTP11995  WD repeat and coiled-coil-containing protein (WDCP) C472
 LDTP11851  Zinc finger protein 106 (ZNF106) C544
 LDTP15714  Mdm2-binding protein (MTBP) C789
 LDTP01456  Pre-mRNA-processing factor 6 (PRPF6) C739
 LDTP11654  PSME3-interacting protein (PSME3IP1) C44
 LDTP09660  PH-interacting protein (PHIP) C1144
 LDTP07918  Nucleolar protein 8 (NOL8) C630
 LDTP02656  Ribonuclease inhibitor (RNH1) C362
 LDTP07738  BCL-6 corepressor (BCOR) C925
 LDTP07959  Protein MCM10 homolog (MCM10) C246
 LDTP12677  DnaJ homolog subfamily C member 11 (DNAJC11) C494
 LDTP11718  Cleavage stimulation factor subunit 2 tau variant (CSTF2T) C222
 LDTP15110  Protein C3orf33 (C3orf33) C275
 LDTP18116  PHD finger protein 3 (PHF3) C606
 LDTP01432  Mitochondrial import receptor subunit TOM70 (TOMM70) C317
 LDTP07918  Nucleolar protein 8 (NOL8) C418
 LDTP09744  Microprocessor complex subunit DGCR8 (DGCR8) C430
 LDTP13935  Protein SGT1 homolog (SUGT1) C49
 LDTP10062  Synapse-associated protein 1 (SYAP1) C283
 LDTP00206  Syntaxin-binding protein 3 (STXBP3) C354
 LDTP19503  Putative tetratricopeptide repeat protein 41 (TTC41P) C555
 LDTP05922  Dynactin subunit 2 (DCTN2) C256
 LDTP14228  Transforming acidic coiled-coil-containing protein 3 (TACC3) C426
 LDTP04206  Nestin (NES) C157
 LDTP06387  Splicing factor 3A subunit 2 (SF3A2) C56
 LDTP04078  Proliferation marker protein Ki-67 (MKI67) C903
 LDTP08110  Neuroepithelial cell-transforming gene 1 protein (NET1) C389
 LDTP03247  Eukaryotic translation initiation factor 4B (EIF4B) C457
 LDTP13935  Protein SGT1 homolog (SUGT1) C54
 LDTP11896  Kinetochore-associated protein DSN1 homolog (DSN1) C65
 LDTP06968  Shugoshin 1 (SGO1) C246
 LDTP12830  U3 small nucleolar RNA-associated protein 6 homolog (UTP6) C370
 LDTP02756  Junction plakoglobin (JUP) C341
 LDTP13963  Probable U3 small nucleolar RNA-associated protein 11 (UTP11) C201
 LDTP13961  Small ribosomal subunit protein uS2m (MRPS2) C162
 LDTP08950  ADP-ribosylation factor GTPase-activating protein 1 (ARFGAP1) C351
 LDTP15333  Trafficking protein particle complex subunit 5 (TRAPPC5) C139
 LDTP11712  Rac GTPase-activating protein 1 (RACGAP1) C327
 LDTP04321  Transcription initiation factor TFIID subunit 6 (TAF6) C231
 LDTP04078  Proliferation marker protein Ki-67 (MKI67) C1843
 LDTP15253  HEAT repeat-containing protein 3 (HEATR3) C266
 LDTP05590  Histone-binding protein RBBP4 (RBBP4) C138
 LDTP13699  Centrosomal protein of 131 kDa (CEP131) C218
 LDTP03612  Bifunctional purine biosynthesis protein ATIC (ATIC) C287
 LDTP00313  Nucleolar protein 56 (NOP56) C384
 LDTP17494  BEN domain-containing protein 4 (BEND4) C354
 LDTP01105  SLIT-ROBO Rho GTPase-activating protein 2 (SRGAP2) C820
 LDTP12518  Bromodomain adjacent to zinc finger domain protein 1A (BAZ1A) C547
 LDTP04201  T-complex protein 1 subunit epsilon (CCT5) C429
 LDTP00880  A-kinase anchor protein 8 (AKAP8) C631

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625