Details of the Target

General Information of Target

Target ID LDTP05071
Target Name Elongation factor 1-alpha 1 (EEF1A1)
Gene Name EEF1A1
Gene ID 1915
Synonyms
EEF1A; EF1A; LENG7; Elongation factor 1-alpha 1; EF-1-alpha-1; EC 3.6.5.-; Elongation factor Tu; EF-Tu; Eukaryotic elongation factor 1 A-1; eEF1A-1; Leukocyte receptor cluster member 7
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGKEKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWVL
DKLKAERERGITIDISLWKFETSKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGV
GEFEAGISKNGQTREHALLAYTLGVKQLIVGVNKMDSTEPPYSQKRYEEIVKEVSTYIKK
IGYNPDTVAFVPISGWNGDNMLEPSANMPWFKGWKVTRKDGNASGTTLLEALDCILPPTR
PTDKPLRLPLQDVYKIGGIGTVPVGRVETGVLKPGMVVTFAPVNVTTEVKSVEMHHEALS
EALPGDNVGFNVKNVSVKDVRRGNVAGDSKNDPPMEAAGFTAQVIILNHPGQISAGYAPV
LDCHTAHIACKFAELKEKIDRRSGKKLEDGPKFLKSGDAAIVDMVPGKPMCVESFSDYPP
LGRFAVRDMRQTVAVGVIKAVDKKAAGAGKVTKSAQKAQKAK
Target Bioclass
Enzyme
Family
TRAFAC class translation factor GTPase superfamily, Classic translation factor GTPase family, EF-Tu/EF-1A subfamily
Subcellular location
Cytoplasm
Function
Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis. Base pairing between the mRNA codon and the aa-tRNA anticodon promotes GTP hydrolysis, releasing the aa-tRNA from EEF1A1 and allowing its accommodation into the ribosome. The growing protein chain is subsequently transferred from the P-site peptidyl tRNA to the A-site aa-tRNA, extending it by one amino acid through ribosome-catalyzed peptide bond formation. Also plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1.; (Microbial infection) Required for the translation of viral proteins and viral replication during human coronavirus SARS-CoV-2 infection.
Uniprot ID
P68104
Ensemble ID
ENST00000309268.11
HGNC ID
HGNC:3189
ChEMBL ID
CHEMBL1795120

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 57 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
A-EBA
 Probe Info  		4.93  LDD0215  [2]
11RK72
 Probe Info  		2.47  LDD0327  [3]
11RK73
 Probe Info  		2.58  LDD0328  [3]
8RK64
 Probe Info  		N.A.  LDD0039  [3]
CHEMBL5175495
 Probe Info  		7.06  LDD0196  [4]
CY4
 Probe Info  		4.44  LDD0244  [5]
N1
 Probe Info  		4.14  LDD0242  [5]
C-Sul
 Probe Info  		2.26  LDD0066  [6]
TH211
 Probe Info  		Y177(20.00); Y85(18.60); Y29(14.46); Y357(14.00)  LDD0257  [7]
TH216
 Probe Info  		Y141(20.00); Y29(20.00); Y86(18.43); Y418(17.61)  LDD0259  [7]
AZ-9
 Probe Info  		E48(0.91); E45(0.93); D252(1.05); D389(0.97)  LDD2208  [8]
OPA-S-S-alkyne
 Probe Info  		K408(1.19); K165(1.78); K255(3.40)  LDD3494  [9]
Probe 1
 Probe Info  		Y29(51.52); Y85(71.90); Y141(101.44); Y254(27.48)  LDD3495  [10]
JZ128-DTB
 Probe Info  		C411(0.00); C363(0.00); C370(0.00); C234(0.00)  LDD0462  [11]
THZ1-DTB
 Probe Info  		C234(1.06); C411(1.07); C363(1.03); C370(1.04)  LDD0460  [11]
AHL-Pu-1
 Probe Info  		C111(7.51)  LDD0168  [12]
EA-probe
 Probe Info  		N.A.  LDD0440  [13]
HHS-482
 Probe Info  		Y141(1.20); Y167(0.78); Y177(0.91); Y183(0.88)  LDD0285  [14]
HHS-475
 Probe Info  		Y418(0.65); Y141(0.76); Y29(0.83); Y86(0.86)  LDD0264  [15]
HHS-465
 Probe Info  		Y141(6.79); Y167(10.00); Y177(8.47); Y254(9.90)  LDD2237  [16]
Acrolein
 Probe Info  		H295(0.00); H296(0.00)  LDD0224  [17]
DBIA
 Probe Info  		C411(0.96)  LDD0078  [18]
5E-2FA
 Probe Info  		H136(0.00); H7(0.00); H26(0.00); H296(0.00)  LDD2235  [19]
AMP probe
 Probe Info  		K392(0.00); K255(0.00); K453(0.00); K450(0.00)  LDD0200  [20]
ATP probe
 Probe Info  		K392(0.00); K255(0.00); K453(0.00); K450(0.00)  LDD0199  [20]
4-Iodoacetamidophenylacetylene
 Probe Info  		C31(0.00); C234(0.00); C363(0.00); C370(0.00)  LDD0038  [21]
IA-alkyne
 Probe Info  		C411(0.00); C234(0.00)  LDD0032  [22]
IPIAA_H
 Probe Info  		C411(0.00); C234(0.00); C363(0.00)  LDD0030  [23]
IPIAA_L
 Probe Info  		C363(0.00); C234(0.00); C411(0.00)  LDD0031  [23]
Lodoacetamide azide
 Probe Info  		C234(0.00); C411(0.00); C363(0.00); C370(0.00)  LDD0037  [21]
Alkyne tyramide
 Probe Info  		K450(0.00); K180(0.00)  LDD0003  [24]
2PCA
 Probe Info  		R321(0.00); K395(0.00); K219(0.00)  LDD0034  [25]
ATP probe
 Probe Info  		K386(0.00); K450(0.00); K172(0.00); K219(0.00)  LDD0035  [26]
BTD
 Probe Info  		N.A.  LDD0004  [24]
JW-RF-010
 Probe Info  		C111(0.00); C31(0.00); C411(0.00); C234(0.00)  LDD0026  [27]
NAIA_4
 Probe Info  		C31(0.00); C363(0.00); C411(0.00)  LDD2226  [28]
TFBX
 Probe Info  		C411(0.00); C31(0.00)  LDD0027  [27]
WYneN
 Probe Info  		C234(0.00); C411(0.00)  LDD0021  [24]
WYneO
 Probe Info  		C411(0.00); C234(0.00)  LDD0022  [24]
1d-yne
 Probe Info  		K244(0.00); K273(0.00); K219(0.00); K408(0.00)  LDD0356  [29]
Compound 10
 Probe Info  		C234(0.00); C411(0.00)  LDD2216  [30]
Compound 11
 Probe Info  		C234(0.00); C411(0.00)  LDD2213  [30]
ENE
 Probe Info  		N.A.  LDD0006  [24]
IPM
 Probe Info  		C411(0.00); C234(0.00)  LDD0005  [24]
NHS
 Probe Info  		K273(0.00); K44(0.00); K392(0.00); K255(0.00)  LDD0010  [24]
OSF
 Probe Info  		H7(0.00); H95(0.00); H26(0.00); Y141(0.00)  LDD0029  [31]
PF-06672131
 Probe Info  		C31(0.00); C411(0.00)  LDD0152  [32]
SF
 Probe Info  		K408(0.00); K392(0.00); Y418(0.00); K30(0.00)  LDD0028  [31]
STPyne
 Probe Info  		K408(0.00); K244(0.00); K172(0.00); K273(0.00)  LDD0009  [24]
VSF
 Probe Info  		C234(0.00); C411(0.00)  LDD0007  [24]
YN-1
 Probe Info  		C234(0.00); C411(0.00)  LDD0446  [33]
Phosphinate-6
 Probe Info  		C363(0.00); C31(0.00); C411(0.00); C111(0.00)  LDD0018  [34]
Ox-W18
 Probe Info  		N.A.  LDD2175  [35]
1c-yne
 Probe Info  		K44(0.00); K154(0.00); K172(0.00); K408(0.00)  LDD0228  [29]
AOyne
 Probe Info  		15.00  LDD0443  [36]
NAIA_5
 Probe Info  		C31(0.00); C111(0.00); C234(0.00); C370(0.00)  LDD2223  [28]
PAL-AfBPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		7.66  LDD0475  [37]
FFF probe3
 Probe Info  		5.65  LDD0465  [37]
FFF probe4
 Probe Info  		5.00  LDD0466  [37]
JN0003
 Probe Info  		5.76  LDD0469  [37]
STS-2
 Probe Info  		N.A.  LDD0138  [38]
VE-P
 Probe Info  		N.A.  LDD0396  [39]
Photocelecoxib
 Probe Info  		E268(0.00); V289(0.00); V405(0.00); E413(0.00)  LDD0019  [40]
DA-2
 Probe Info  		N.A.  LDD0073  [41]
STS-1
 Probe Info  		N.A.  LDD0069  [42]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C411(0.91); C234(0.54)  LDD2142  [43]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C411(1.01); C31(0.93)  LDD2112  [43]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C411(0.66)  LDD2095  [43]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C411(0.91)  LDD2130  [43]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C411(1.11)  LDD2117  [43]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C411(1.11)  LDD2152  [43]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C411(0.96)  LDD2103  [43]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C411(0.66)  LDD2132  [43]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C411(0.86); C234(0.74)  LDD2131  [43]
 LDCM0025  4SU-RNA HEK-293T C111(7.51)  LDD0168  [12]
 LDCM0026  4SU-RNA+native RNA HEK-293T C234(2.21)  LDD0169  [12]
 LDCM0214  AC1 HCT 116 C411(0.88); C363(0.60); C370(0.63)  LDD0531  [18]
 LDCM0215  AC10 HCT 116 C411(1.12); C363(0.69); C370(0.65)  LDD0532  [18]
 LDCM0216  AC100 HCT 116 C411(0.91); C363(0.83); C370(0.81)  LDD0533  [18]
 LDCM0217  AC101 HCT 116 C411(1.02); C363(1.43); C370(1.38)  LDD0534  [18]
 LDCM0218  AC102 HCT 116 C411(1.05); C363(1.16); C370(1.14)  LDD0535  [18]
 LDCM0219  AC103 HCT 116 C411(1.13); C363(1.32); C370(1.33)  LDD0536  [18]
 LDCM0220  AC104 HCT 116 C411(1.13); C363(1.28); C370(1.32)  LDD0537  [18]
 LDCM0221  AC105 HCT 116 C411(0.97); C363(1.10); C370(1.13)  LDD0538  [18]
 LDCM0222  AC106 HCT 116 C411(1.04); C363(1.19); C370(1.24)  LDD0539  [18]
 LDCM0223  AC107 HCT 116 C411(1.08); C363(1.23); C370(1.27)  LDD0540  [18]
 LDCM0224  AC108 HCT 116 C411(0.92); C363(0.88); C370(0.89)  LDD0541  [18]
 LDCM0225  AC109 HCT 116 C411(1.09); C363(0.99); C370(1.01)  LDD0542  [18]
 LDCM0226  AC11 HCT 116 C411(1.39); C363(0.81); C370(0.91)  LDD0543  [18]
 LDCM0227  AC110 HCT 116 C411(1.07); C363(1.12); C370(1.09)  LDD0544  [18]
 LDCM0228  AC111 HCT 116 C411(1.22); C363(1.42); C370(1.46)  LDD0545  [18]
 LDCM0229  AC112 HCT 116 C411(1.34); C363(1.39); C370(1.35)  LDD0546  [18]
 LDCM0230  AC113 HCT 116 C411(0.95); C363(0.79); C370(0.88)  LDD0547  [18]
 LDCM0231  AC114 HCT 116 C411(0.97); C363(0.92); C370(0.88)  LDD0548  [18]
 LDCM0232  AC115 HCT 116 C411(0.92); C363(0.99); C370(0.99)  LDD0549  [18]
 LDCM0233  AC116 HCT 116 C411(0.94); C363(0.88); C370(0.84)  LDD0550  [18]
 LDCM0234  AC117 HCT 116 C411(1.00); C363(0.72); C370(0.72)  LDD0551  [18]
 LDCM0235  AC118 HCT 116 C411(1.07); C363(0.86); C370(0.86)  LDD0552  [18]
 LDCM0236  AC119 HCT 116 C411(1.12); C363(0.73); C370(0.75)  LDD0553  [18]
 LDCM0237  AC12 HCT 116 C411(1.02); C363(0.65); C370(0.66)  LDD0554  [18]
 LDCM0238  AC120 HCT 116 C411(1.01); C363(0.80); C370(1.18)  LDD0555  [18]
 LDCM0239  AC121 HCT 116 C411(0.90); C363(0.78); C370(0.82)  LDD0556  [18]
 LDCM0240  AC122 HCT 116 C411(1.18); C363(0.86); C370(0.83)  LDD0557  [18]
 LDCM0241  AC123 HCT 116 C411(0.90); C363(0.79); C370(0.88)  LDD0558  [18]
 LDCM0242  AC124 HCT 116 C411(0.93); C363(0.69); C370(0.75)  LDD0559  [18]
 LDCM0243  AC125 HCT 116 C411(0.97); C363(0.78); C370(0.86)  LDD0560  [18]
 LDCM0244  AC126 HCT 116 C411(0.95); C363(0.77); C370(0.85)  LDD0561  [18]
 LDCM0245  AC127 HCT 116 C411(1.03); C363(0.75); C370(0.75)  LDD0562  [18]
 LDCM0246  AC128 HCT 116 C363(0.84); C370(0.82)  LDD0563  [18]
 LDCM0247  AC129 HCT 116 C363(0.55); C370(0.58)  LDD0564  [18]
 LDCM0249  AC130 HCT 116 C363(0.58); C370(0.69)  LDD0566  [18]
 LDCM0250  AC131 HCT 116 C363(1.09); C370(0.94)  LDD0567  [18]
 LDCM0251  AC132 HCT 116 C363(0.53); C370(0.61)  LDD0568  [18]
 LDCM0252  AC133 HCT 116 C363(0.66); C370(0.82)  LDD0569  [18]
 LDCM0253  AC134 HCT 116 C363(1.08); C370(1.00)  LDD0570  [18]
 LDCM0254  AC135 HCT 116 C363(0.62); C370(0.60)  LDD0571  [18]
 LDCM0255  AC136 HCT 116 C363(0.76); C370(0.94)  LDD0572  [18]
 LDCM0256  AC137 HCT 116 C363(0.75); C370(0.78)  LDD0573  [18]
 LDCM0257  AC138 HCT 116 C363(1.39); C370(1.35)  LDD0574  [18]
 LDCM0258  AC139 HCT 116 C363(0.72); C370(0.84)  LDD0575  [18]
 LDCM0259  AC14 HCT 116 C411(1.11); C363(1.39); C370(1.67)  LDD0576  [18]
 LDCM0260  AC140 HCT 116 C363(1.00); C370(1.03)  LDD0577  [18]
 LDCM0261  AC141 HCT 116 C363(1.09); C370(1.04)  LDD0578  [18]
 LDCM0262  AC142 HCT 116 C363(0.67); C370(0.76)  LDD0579  [18]
 LDCM0263  AC143 HCT 116 C411(1.01); C363(1.19); C370(1.14)  LDD0580  [18]
 LDCM0264  AC144 HCT 116 C363(0.81); C370(0.86); C411(0.97)  LDD0581  [18]
 LDCM0265  AC145 HCT 116 C411(0.77); C370(0.85); C363(0.87)  LDD0582  [18]
 LDCM0266  AC146 HCT 116 C411(0.79); C363(0.89); C370(0.91)  LDD0583  [18]
 LDCM0267  AC147 HCT 116 C411(0.77); C370(1.00); C363(1.03)  LDD0584  [18]
 LDCM0268  AC148 HCT 116 C411(0.75); C363(0.98); C370(1.04)  LDD0585  [18]
 LDCM0269  AC149 HCT 116 C411(0.96); C363(1.03); C370(1.12)  LDD0586  [18]
 LDCM0270  AC15 HCT 116 C411(1.01); C363(1.01); C370(1.06)  LDD0587  [18]
 LDCM0271  AC150 HCT 116 C411(0.63); C363(0.79); C370(0.90)  LDD0588  [18]
 LDCM0272  AC151 HCT 116 C363(0.80); C370(0.86); C411(0.97)  LDD0589  [18]
 LDCM0273  AC152 HCT 116 C411(0.64); C363(1.12); C370(1.24)  LDD0590  [18]
 LDCM0274  AC153 HCT 116 C363(0.82); C411(0.92); C370(1.02)  LDD0591  [18]
 LDCM0621  AC154 HCT 116 C411(0.80); C363(0.90); C370(0.88)  LDD2158  [18]
 LDCM0622  AC155 HCT 116 C411(0.98); C363(0.72); C370(0.83)  LDD2159  [18]
 LDCM0623  AC156 HCT 116 C411(0.81); C363(0.96); C370(1.03)  LDD2160  [18]
 LDCM0624  AC157 HCT 116 C411(0.61); C363(0.91); C370(1.00)  LDD2161  [18]
 LDCM0276  AC17 HCT 116 C411(0.36); C363(0.66); C370(0.67)  LDD0593  [18]
 LDCM0277  AC18 HCT 116 C411(0.46); C363(0.98); C370(0.98)  LDD0594  [18]
 LDCM0278  AC19 HCT 116 C411(0.40); C363(0.86); C370(0.89)  LDD0595  [18]
 LDCM0279  AC2 HCT 116 C363(0.61); C370(0.66); C411(0.80)  LDD0596  [18]
 LDCM0280  AC20 HCT 116 C411(0.42); C363(1.10); C370(1.10)  LDD0597  [18]
 LDCM0281  AC21 HCT 116 C411(0.43); C363(0.82); C370(0.84)  LDD0598  [18]
 LDCM0282  AC22 HCT 116 C411(0.41); C370(0.55); C363(0.55)  LDD0599  [18]
 LDCM0283  AC23 HCT 116 C411(0.36); C363(0.65); C370(0.66)  LDD0600  [18]
 LDCM0284  AC24 HCT 116 C411(0.36); C370(1.05); C363(1.05)  LDD0601  [18]
 LDCM0285  AC25 HCT 116 C370(0.63); C363(0.65); C411(11.76)  LDD0602  [18]
 LDCM0286  AC26 HCT 116 C370(0.58); C363(0.60); C411(8.19)  LDD0603  [18]
 LDCM0287  AC27 HCT 116 C370(0.66); C363(0.69); C411(10.92)  LDD0604  [18]
 LDCM0288  AC28 HCT 116 C370(0.52); C363(0.54); C411(10.97)  LDD0605  [18]
 LDCM0289  AC29 HCT 116 C370(0.77); C363(0.77); C411(9.69)  LDD0606  [18]
 LDCM0290  AC3 HCT 116 C370(0.54); C363(0.55); C411(0.79)  LDD0607  [18]
 LDCM0291  AC30 HCT 116 C370(0.92); C363(0.92); C411(9.55)  LDD0608  [18]
 LDCM0292  AC31 HCT 116 C370(0.65); C363(0.65); C411(6.53)  LDD0609  [18]
 LDCM0293  AC32 HCT 116 C363(0.86); C370(0.88); C411(7.13)  LDD0610  [18]
 LDCM0294  AC33 HCT 116 C370(0.93); C363(0.94); C411(11.37)  LDD0611  [18]
 LDCM0295  AC34 HCT 116 C363(1.44); C370(1.55); C411(10.57)  LDD0612  [18]
 LDCM0296  AC35 HCT 116 C411(1.30)  LDD0613  [18]
 LDCM0297  AC36 HCT 116 C411(1.93)  LDD0614  [18]
 LDCM0298  AC37 HCT 116 C411(1.68)  LDD0615  [18]
 LDCM0299  AC38 HCT 116 C411(1.54)  LDD0616  [18]
 LDCM0300  AC39 HCT 116 C411(2.22)  LDD0617  [18]
 LDCM0301  AC4 HCT 116 C363(0.52); C370(0.57); C411(0.82)  LDD0618  [18]
 LDCM0302  AC40 HCT 116 C411(1.78)  LDD0619  [18]
 LDCM0303  AC41 HCT 116 C411(1.29)  LDD0620  [18]
 LDCM0304  AC42 HCT 116 C411(1.63)  LDD0621  [18]
 LDCM0305  AC43 HCT 116 C411(1.58)  LDD0622  [18]
 LDCM0306  AC44 HCT 116 C411(1.43)  LDD0623  [18]
 LDCM0307  AC45 HCT 116 C411(1.31)  LDD0624  [18]
 LDCM0308  AC46 HCT 116 C363(0.93); C370(0.94); C411(1.07)  LDD0625  [18]
 LDCM0309  AC47 HCT 116 C363(0.80); C370(0.81); C411(1.33)  LDD0626  [18]
 LDCM0310  AC48 HCT 116 C370(0.95); C363(0.96); C411(1.24)  LDD0627  [18]
 LDCM0311  AC49 HCT 116 C411(0.98); C363(1.24); C370(1.27)  LDD0628  [18]
 LDCM0312  AC5 HCT 116 C363(0.44); C370(0.47); C411(0.73)  LDD0629  [18]
 LDCM0313  AC50 HCT 116 C411(1.09); C363(1.24); C370(1.25)  LDD0630  [18]
 LDCM0314  AC51 HCT 116 C370(1.26); C363(1.29); C411(1.45)  LDD0631  [18]
 LDCM0315  AC52 HCT 116 C363(1.00); C370(1.00); C411(1.66)  LDD0632  [18]
 LDCM0316  AC53 HCT 116 C363(1.13); C370(1.16); C411(1.68)  LDD0633  [18]
 LDCM0317  AC54 HCT 116 C363(1.05); C370(1.05); C411(1.85)  LDD0634  [18]
 LDCM0318  AC55 HCT 116 C363(0.81); C370(0.84); C411(1.58)  LDD0635  [18]
 LDCM0319  AC56 HCT 116 C363(1.18); C370(1.22); C411(1.54)  LDD0636  [18]
 LDCM0320  AC57 HCT 116 C411(1.15); C370(1.45); C363(1.49)  LDD0637  [18]
 LDCM0321  AC58 HCT 116 C411(1.14); C370(1.25); C363(1.43)  LDD0638  [18]
 LDCM0322  AC59 HCT 116 C370(0.98); C363(1.02); C411(1.15)  LDD0639  [18]
 LDCM0323  AC6 HCT 116 C363(0.88); C370(0.92); C411(1.03)  LDD0640  [18]
 LDCM0324  AC60 HCT 116 C411(1.24); C370(2.18); C363(2.21)  LDD0641  [18]
 LDCM0325  AC61 HCT 116 C370(0.80); C363(0.82); C411(1.03)  LDD0642  [18]
 LDCM0326  AC62 HCT 116 C370(1.19); C411(1.25); C363(1.26)  LDD0643  [18]
 LDCM0327  AC63 HCT 116 C411(1.37); C370(1.74); C363(1.77)  LDD0644  [18]
 LDCM0328  AC64 HCT 116 C411(1.25); C370(1.28); C363(1.29)  LDD0645  [18]
 LDCM0329  AC65 HCT 116 C411(1.16); C370(2.14); C363(2.15)  LDD0646  [18]
 LDCM0330  AC66 HCT 116 C411(1.21); C370(1.45); C363(1.51)  LDD0647  [18]
 LDCM0331  AC67 HCT 116 C411(1.26); C363(1.71); C370(1.73)  LDD0648  [18]
 LDCM0332  AC68 HCT 116 C411(0.83); C370(1.19); C363(1.28)  LDD0649  [18]
 LDCM0333  AC69 HCT 116 C411(0.73); C370(1.08); C363(1.16)  LDD0650  [18]
 LDCM0334  AC7 HCT 116 C363(0.75); C370(0.79); C411(1.00)  LDD0651  [18]
 LDCM0335  AC70 HCT 116 C370(1.09); C363(1.14); C411(1.34)  LDD0652  [18]
 LDCM0336  AC71 HCT 116 C411(0.85); C370(0.96); C363(1.02)  LDD0653  [18]
 LDCM0337  AC72 HCT 116 C411(1.03); C363(1.12); C370(1.14)  LDD0654  [18]
 LDCM0338  AC73 HCT 116 C370(1.02); C411(1.05); C363(1.07)  LDD0655  [18]
 LDCM0339  AC74 HCT 116 C411(0.80); C370(1.19); C363(1.30)  LDD0656  [18]
 LDCM0340  AC75 HCT 116 C370(1.10); C363(1.11); C411(1.15)  LDD0657  [18]
 LDCM0341  AC76 HCT 116 C363(0.92); C370(0.94); C411(1.20)  LDD0658  [18]
 LDCM0342  AC77 HCT 116 C411(0.87); C370(1.40); C363(1.42)  LDD0659  [18]
 LDCM0343  AC78 HCT 116 C411(0.79); C370(1.06); C363(1.11)  LDD0660  [18]
 LDCM0344  AC79 HCT 116 C411(0.94); C370(1.22); C363(1.25)  LDD0661  [18]
 LDCM0345  AC8 HCT 116 C363(0.94); C370(0.94); C411(1.10)  LDD0662  [18]
 LDCM0346  AC80 HCT 116 C370(0.93); C363(0.93); C411(1.07)  LDD0663  [18]
 LDCM0347  AC81 HCT 116 C411(0.90); C370(1.10); C363(1.12)  LDD0664  [18]
 LDCM0348  AC82 HCT 116 C411(1.01); C363(1.11); C370(1.12)  LDD0665  [18]
 LDCM0349  AC83 HCT 116 C363(0.98); C370(1.05); C411(1.14)  LDD0666  [18]
 LDCM0350  AC84 HCT 116 C411(1.13); C370(1.78); C363(2.02)  LDD0667  [18]
 LDCM0351  AC85 HCT 116 C370(0.98); C363(1.10); C411(1.17)  LDD0668  [18]
 LDCM0352  AC86 HCT 116 C411(1.13); C370(1.24); C363(1.41)  LDD0669  [18]
 LDCM0353  AC87 HCT 116 C370(0.88); C363(0.91); C411(1.02)  LDD0670  [18]
 LDCM0354  AC88 HCT 116 C411(0.93); C370(1.04); C363(1.10)  LDD0671  [18]
 LDCM0355  AC89 HCT 116 C411(0.91); C370(1.09); C363(1.32)  LDD0672  [18]
 LDCM0357  AC90 HCT 116 C363(0.61); C370(0.62); C411(0.92)  LDD0674  [18]
 LDCM0358  AC91 HCT 116 C363(0.91); C370(0.92); C411(1.33)  LDD0675  [18]
 LDCM0359  AC92 HCT 116 C370(0.70); C363(0.77); C411(1.35)  LDD0676  [18]
 LDCM0360  AC93 HCT 116 C370(0.93); C411(0.97); C363(1.03)  LDD0677  [18]
 LDCM0361  AC94 HCT 116 C370(0.75); C363(0.82); C411(1.95)  LDD0678  [18]
 LDCM0362  AC95 HCT 116 C363(0.78); C370(0.81); C411(1.31)  LDD0679  [18]
 LDCM0363  AC96 HCT 116 C363(0.68); C370(0.70); C411(1.33)  LDD0680  [18]
 LDCM0364  AC97 HCT 116 C363(0.74); C370(0.74); C411(1.68)  LDD0681  [18]
 LDCM0365  AC98 HCT 116 C411(0.98); C363(1.04); C370(1.05)  LDD0682  [18]
 LDCM0366  AC99 HCT 116 C370(0.85); C363(0.86); C411(0.86)  LDD0683  [18]
 LDCM0545  Acetamide MDA-MB-231 C411(0.57)  LDD2138  [43]
 LDCM0520  AKOS000195272 MDA-MB-231 C411(0.77)  LDD2113  [43]
 LDCM0248  AKOS034007472 HCT 116 C411(1.08); C363(0.70); C370(0.76)  LDD0565  [18]
 LDCM0356  AKOS034007680 HCT 116 C363(0.77); C370(0.83); C411(1.15)  LDD0673  [18]
 LDCM0275  AKOS034007705 HCT 116 C363(0.97); C411(1.01); C370(1.08)  LDD0592  [18]
 LDCM0156  Aniline NCI-H1299 12.22  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C411(0.96)  LDD0078  [18]
 LDCM0498  BS-3668 MDA-MB-231 C411(0.81)  LDD2091  [43]
 LDCM0367  CL1 HCT 116 C363(0.59); C370(0.59); C411(0.90)  LDD0684  [18]
 LDCM0368  CL10 HCT 116 C363(0.22); C370(0.22); C411(0.66)  LDD0685  [18]
 LDCM0369  CL100 HCT 116 C370(0.61); C363(0.63); C411(0.88)  LDD0686  [18]
 LDCM0370  CL101 HCT 116 C411(0.97); C363(1.56); C370(1.71)  LDD0687  [18]
 LDCM0371  CL102 HCT 116 C411(0.90); C363(1.82); C370(2.02)  LDD0688  [18]
 LDCM0372  CL103 HCT 116 C411(1.02); C363(1.35); C370(1.53)  LDD0689  [18]
 LDCM0373  CL104 HCT 116 C411(0.98); C363(1.39); C370(1.49)  LDD0690  [18]
 LDCM0374  CL105 HCT 116 C411(0.38); C363(0.60); C370(0.60)  LDD0691  [18]
 LDCM0375  CL106 HCT 116 C411(0.39); C363(0.52); C370(0.52)  LDD0692  [18]
 LDCM0376  CL107 HCT 116 C411(0.41); C363(0.65); C370(0.66)  LDD0693  [18]
 LDCM0377  CL108 HCT 116 C411(0.36); C370(0.50); C363(0.50)  LDD0694  [18]
 LDCM0378  CL109 HCT 116 C411(0.40); C363(0.83); C370(0.86)  LDD0695  [18]
 LDCM0379  CL11 HCT 116 C363(0.20); C370(0.20); C411(0.57)  LDD0696  [18]
 LDCM0380  CL110 HCT 116 C411(0.32); C363(0.59); C370(0.63)  LDD0697  [18]
 LDCM0381  CL111 HCT 116 C411(0.40); C363(0.69); C370(0.72)  LDD0698  [18]
 LDCM0382  CL112 HCT 116 C363(1.05); C370(1.05); C411(5.33)  LDD0699  [18]
 LDCM0383  CL113 HCT 116 C370(1.10); C363(1.11); C411(8.42)  LDD0700  [18]
 LDCM0384  CL114 HCT 116 C363(1.07); C370(1.15); C411(10.03)  LDD0701  [18]
 LDCM0385  CL115 HCT 116 C363(1.31); C370(1.38); C411(11.07)  LDD0702  [18]
 LDCM0386  CL116 HCT 116 C370(1.08); C363(1.12); C411(10.89)  LDD0703  [18]
 LDCM0387  CL117 HCT 116 C411(1.20)  LDD0704  [18]
 LDCM0388  CL118 HCT 116 C411(1.04)  LDD0705  [18]
 LDCM0389  CL119 HCT 116 C411(1.40)  LDD0706  [18]
 LDCM0390  CL12 HCT 116 C363(0.25); C370(0.25); C411(0.65)  LDD0707  [18]
 LDCM0391  CL120 HCT 116 C411(1.78)  LDD0708  [18]
 LDCM0392  CL121 HCT 116 C370(0.97); C363(1.00); C411(1.53)  LDD0709  [18]
 LDCM0393  CL122 HCT 116 C370(1.10); C363(1.17); C411(1.76)  LDD0710  [18]
 LDCM0394  CL123 HCT 116 C363(0.69); C370(0.70); C411(1.28)  LDD0711  [18]
 LDCM0395  CL124 HCT 116 C370(0.88); C363(0.89); C411(1.46)  LDD0712  [18]
 LDCM0396  CL125 HCT 116 C411(1.03); C370(1.59); C363(1.64)  LDD0713  [18]
 LDCM0397  CL126 HCT 116 C411(0.98); C370(1.36); C363(1.40)  LDD0714  [18]
 LDCM0398  CL127 HCT 116 C411(1.00); C370(1.10); C363(1.15)  LDD0715  [18]
 LDCM0399  CL128 HCT 116 C411(0.99); C370(1.74); C363(1.76)  LDD0716  [18]
 LDCM0400  CL13 HCT 116 C363(0.52); C370(0.52); C411(0.97)  LDD0717  [18]
 LDCM0401  CL14 HCT 116 C363(0.52); C370(0.52); C411(0.88)  LDD0718  [18]
 LDCM0402  CL15 HCT 116 C411(0.84); C363(0.92); C370(0.92)  LDD0719  [18]
 LDCM0403  CL16 HCT 116 C363(0.52); C370(0.52); C411(1.08)  LDD0720  [18]
 LDCM0404  CL17 HCT 116 C363(0.82); C370(0.84); C411(1.03)  LDD0721  [18]
 LDCM0405  CL18 HCT 116 C370(0.66); C363(0.67); C411(1.06)  LDD0722  [18]
 LDCM0406  CL19 HCT 116 C370(0.90); C363(0.91); C411(1.05)  LDD0723  [18]
 LDCM0407  CL2 HCT 116 C363(0.89); C370(0.89); C411(0.96)  LDD0724  [18]
 LDCM0408  CL20 HCT 116 C370(0.82); C363(0.86); C411(1.03)  LDD0725  [18]
 LDCM0409  CL21 HCT 116 C363(0.65); C370(0.66); C411(0.87)  LDD0726  [18]
 LDCM0410  CL22 HCT 116 C411(0.84); C370(1.11); C363(1.15)  LDD0727  [18]
 LDCM0411  CL23 HCT 116 C411(0.85); C370(0.94); C363(0.97)  LDD0728  [18]
 LDCM0412  CL24 HCT 116 C363(0.62); C370(0.64); C411(0.92)  LDD0729  [18]
 LDCM0413  CL25 HCT 116 C411(0.90); C363(0.49); C370(0.47)  LDD0730  [18]
 LDCM0414  CL26 HCT 116 C411(1.16); C363(0.84); C370(0.87)  LDD0731  [18]
 LDCM0415  CL27 HCT 116 C411(0.90); C363(0.64); C370(0.61)  LDD0732  [18]
 LDCM0416  CL28 HCT 116 C411(1.06); C363(0.61); C370(0.63)  LDD0733  [18]
 LDCM0417  CL29 HCT 116 C411(0.93); C363(0.99); C370(0.93)  LDD0734  [18]
 LDCM0418  CL3 HCT 116 C411(0.94); C363(0.86); C370(0.86)  LDD0735  [18]
 LDCM0419  CL30 HCT 116 C411(0.94); C363(0.76); C370(0.72)  LDD0736  [18]
 LDCM0420  CL31 HCT 116 C411(0.98); C363(0.93); C370(0.95)  LDD0737  [18]
 LDCM0421  CL32 HCT 116 C411(1.07); C363(0.81); C370(0.82)  LDD0738  [18]
 LDCM0422  CL33 HCT 116 C411(0.71); C363(1.00); C370(0.99)  LDD0739  [18]
 LDCM0423  CL34 HCT 116 C411(1.03); C363(0.90); C370(1.01)  LDD0740  [18]
 LDCM0424  CL35 HCT 116 C411(0.78); C363(1.59); C370(1.36)  LDD0741  [18]
 LDCM0425  CL36 HCT 116 C411(0.98); C363(1.08); C370(0.85)  LDD0742  [18]
 LDCM0426  CL37 HCT 116 C411(0.83); C363(1.43); C370(1.12)  LDD0743  [18]
 LDCM0428  CL39 HCT 116 C411(0.92); C363(1.01); C370(0.78)  LDD0745  [18]
 LDCM0429  CL4 HCT 116 C411(0.97); C363(0.78); C370(0.78)  LDD0746  [18]
 LDCM0430  CL40 HCT 116 C411(0.81); C363(1.02); C370(0.74)  LDD0747  [18]
 LDCM0431  CL41 HCT 116 C411(1.05); C363(1.33); C370(1.51)  LDD0748  [18]
 LDCM0432  CL42 HCT 116 C411(0.96); C363(1.56); C370(0.88)  LDD0749  [18]
 LDCM0433  CL43 HCT 116 C411(0.89); C363(1.11); C370(0.90)  LDD0750  [18]
 LDCM0434  CL44 HCT 116 C411(0.74); C363(1.01); C370(0.96)  LDD0751  [18]
 LDCM0435  CL45 HCT 116 C411(0.71); C363(0.80); C370(0.88)  LDD0752  [18]
 LDCM0436  CL46 HCT 116 C411(0.89); C363(0.76); C370(0.72)  LDD0753  [18]
 LDCM0437  CL47 HCT 116 C411(0.90); C363(1.07); C370(0.93)  LDD0754  [18]
 LDCM0438  CL48 HCT 116 C411(0.98); C363(1.28); C370(1.07)  LDD0755  [18]
 LDCM0439  CL49 HCT 116 C411(0.94); C363(0.93); C370(0.84)  LDD0756  [18]
 LDCM0440  CL5 HCT 116 C411(0.80); C363(1.07); C370(1.07)  LDD0757  [18]
 LDCM0441  CL50 HCT 116 C411(1.00); C363(1.57); C370(1.38)  LDD0758  [18]
 LDCM0442  CL51 HCT 116 C411(0.91); C363(0.92); C370(0.81)  LDD0759  [18]
 LDCM0443  CL52 HCT 116 C411(1.08); C363(1.05); C370(0.99)  LDD0760  [18]
 LDCM0444  CL53 HCT 116 C411(1.14); C363(1.09); C370(1.63)  LDD0761  [18]
 LDCM0445  CL54 HCT 116 C411(1.04); C363(0.95); C370(0.92)  LDD0762  [18]
 LDCM0446  CL55 HCT 116 C411(1.02); C363(0.83); C370(0.78)  LDD0763  [18]
 LDCM0447  CL56 HCT 116 C411(1.01); C363(1.14); C370(1.14)  LDD0764  [18]
 LDCM0448  CL57 HCT 116 C411(0.98); C363(0.79); C370(0.90)  LDD0765  [18]
 LDCM0449  CL58 HCT 116 C411(1.04); C363(1.09); C370(0.96)  LDD0766  [18]
 LDCM0450  CL59 HCT 116 C411(1.02); C363(1.24); C370(1.07)  LDD0767  [18]
 LDCM0451  CL6 HCT 116 C411(0.87); C363(0.92); C370(0.92)  LDD0768  [18]
 LDCM0452  CL60 HCT 116 C411(1.07); C363(0.75); C370(0.82)  LDD0769  [18]
 LDCM0453  CL61 HCT 116 C411(1.22); C363(1.14); C370(0.73)  LDD0770  [18]
 LDCM0454  CL62 HCT 116 C411(1.22); C363(1.03); C370(0.65)  LDD0771  [18]
 LDCM0455  CL63 HCT 116 C411(1.21); C363(1.49); C370(0.82)  LDD0772  [18]
 LDCM0456  CL64 HCT 116 C411(1.06); C363(1.27); C370(0.84)  LDD0773  [18]
 LDCM0457  CL65 HCT 116 C411(1.26); C363(1.61); C370(0.96)  LDD0774  [18]
 LDCM0458  CL66 HCT 116 C411(1.43); C363(1.23); C370(0.70)  LDD0775  [18]
 LDCM0459  CL67 HCT 116 C411(1.35); C363(1.77); C370(0.74)  LDD0776  [18]
 LDCM0460  CL68 HCT 116 C411(1.30); C363(2.82); C370(1.32)  LDD0777  [18]
 LDCM0461  CL69 HCT 116 C411(1.44); C363(1.61); C370(1.15)  LDD0778  [18]
 LDCM0462  CL7 HCT 116 C411(0.72); C363(0.33); C370(0.33)  LDD0779  [18]
 LDCM0463  CL70 HCT 116 C411(1.53); C363(1.30); C370(1.16)  LDD0780  [18]
 LDCM0464  CL71 HCT 116 C411(1.37); C363(1.69); C370(1.14)  LDD0781  [18]
 LDCM0465  CL72 HCT 116 C411(1.43); C363(1.75); C370(1.28)  LDD0782  [18]
 LDCM0466  CL73 HCT 116 C411(1.32); C363(2.03); C370(1.26)  LDD0783  [18]
 LDCM0467  CL74 HCT 116 C411(1.50); C363(1.91); C370(1.39)  LDD0784  [18]
 LDCM0469  CL76 HCT 116 C411(0.83); C363(1.56); C370(1.97)  LDD0786  [18]
 LDCM0470  CL77 HCT 116 C411(0.85); C363(1.92); C370(2.14)  LDD0787  [18]
 LDCM0471  CL78 HCT 116 C411(0.90); C363(1.20); C370(1.23)  LDD0788  [18]
 LDCM0472  CL79 HCT 116 C411(0.86); C363(1.31); C370(1.32)  LDD0789  [18]
 LDCM0473  CL8 HCT 116 C411(0.93); C363(0.62); C370(0.62)  LDD0790  [18]
 LDCM0474  CL80 HCT 116 C411(0.97); C363(0.94); C370(1.00)  LDD0791  [18]
 LDCM0475  CL81 HCT 116 C411(0.89); C363(1.17); C370(1.22)  LDD0792  [18]
 LDCM0476  CL82 HCT 116 C411(0.90); C363(0.97); C370(1.04)  LDD0793  [18]
 LDCM0477  CL83 HCT 116 C411(0.81); C363(0.92); C370(0.90)  LDD0794  [18]
 LDCM0478  CL84 HCT 116 C411(0.86); C363(0.98); C370(0.99)  LDD0795  [18]
 LDCM0479  CL85 HCT 116 C411(0.97); C363(1.33); C370(1.41)  LDD0796  [18]
 LDCM0480  CL86 HCT 116 C411(0.93); C363(1.35); C370(1.52)  LDD0797  [18]
 LDCM0481  CL87 HCT 116 C411(0.91); C363(1.19); C370(1.41)  LDD0798  [18]
 LDCM0482  CL88 HCT 116 C411(0.91); C363(1.39); C370(1.50)  LDD0799  [18]
 LDCM0483  CL89 HCT 116 C411(0.90); C363(0.97); C370(0.99)  LDD0800  [18]
 LDCM0484  CL9 HCT 116 C411(1.12); C363(0.55); C370(0.55)  LDD0801  [18]
 LDCM0485  CL90 HCT 116 C411(0.76); C363(1.21); C370(1.26)  LDD0802  [18]
 LDCM0486  CL91 HCT 116 C411(1.00); C363(0.73); C370(0.93)  LDD0803  [18]
 LDCM0487  CL92 HCT 116 C411(0.92); C363(1.35); C370(1.28)  LDD0804  [18]
 LDCM0488  CL93 HCT 116 C411(0.65); C363(0.87); C370(0.91)  LDD0805  [18]
 LDCM0489  CL94 HCT 116 C411(0.81); C363(1.25); C370(1.34)  LDD0806  [18]
 LDCM0490  CL95 HCT 116 C411(0.70); C363(1.01); C370(1.03)  LDD0807  [18]
 LDCM0491  CL96 HCT 116 C411(0.81); C363(0.87); C370(0.89)  LDD0808  [18]
 LDCM0492  CL97 HCT 116 C411(0.81); C363(0.85); C370(0.82)  LDD0809  [18]
 LDCM0493  CL98 HCT 116 C411(0.86); C363(0.67); C370(0.64)  LDD0810  [18]
 LDCM0494  CL99 HCT 116 C411(0.84); C363(0.57); C370(0.64)  LDD0811  [18]
 LDCM0495  E2913 HEK-293T C411(1.01); C363(1.15); C370(1.07); C234(1.13)  LDD1698  [44]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C411(2.66); C234(2.56)  LDD1702  [43]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [13]
 LDCM0625  F8 Ramos C411(1.21); C234(1.19); C31(1.15)  LDD2187  [45]
 LDCM0572  Fragment10 Ramos C411(1.71); C234(0.60); C31(5.38)  LDD2189  [45]
 LDCM0573  Fragment11 Ramos C411(0.01); C234(0.07); C31(11.52)  LDD2190  [45]
 LDCM0574  Fragment12 Ramos C411(1.40); C234(0.68); C31(5.56)  LDD2191  [45]
 LDCM0575  Fragment13 Ramos C411(1.06); C234(0.79); C31(1.10)  LDD2192  [45]
 LDCM0576  Fragment14 Ramos C411(1.03); C234(1.35); C31(4.45)  LDD2193  [45]
 LDCM0579  Fragment20 Ramos C411(1.88); C234(0.64); C31(9.19)  LDD2194  [45]
 LDCM0580  Fragment21 Ramos C411(0.88); C234(0.75); C31(1.11)  LDD2195  [45]
 LDCM0582  Fragment23 Ramos C411(1.07); C234(1.17); C31(0.96)  LDD2196  [45]
 LDCM0578  Fragment27 Ramos C411(1.03); C234(1.69); C31(1.13)  LDD2197  [45]
 LDCM0586  Fragment28 Ramos C411(0.36); C234(0.98); C31(0.40)  LDD2198  [45]
 LDCM0588  Fragment30 Ramos C411(0.95); C234(0.79); C31(1.49)  LDD2199  [45]
 LDCM0589  Fragment31 Ramos C411(1.18); C234(0.98); C31(1.22)  LDD2200  [45]
 LDCM0590  Fragment32 Ramos C411(1.79); C234(0.81); C31(7.22)  LDD2201  [45]
 LDCM0468  Fragment33 HCT 116 C411(1.38); C363(1.26); C370(0.86)  LDD0785  [18]
 LDCM0596  Fragment38 Ramos C411(0.86); C234(1.50); C31(1.05)  LDD2203  [45]
 LDCM0566  Fragment4 Ramos C411(1.40); C234(0.71); C31(1.02)  LDD2184  [45]
 LDCM0427  Fragment51 HCT 116 C411(0.95); C363(1.30); C370(0.57)  LDD0744  [18]
 LDCM0610  Fragment52 Ramos C411(0.91); C234(0.98); C31(1.65)  LDD2204  [45]
 LDCM0614  Fragment56 Ramos C411(1.09); C234(0.91); C31(2.30)  LDD2205  [45]
 LDCM0569  Fragment7 Ramos C411(1.77); C234(0.94); C31(3.93)  LDD2186  [45]
 LDCM0571  Fragment9 Ramos C411(1.81); C234(0.50); C31(8.05)  LDD2188  [45]
 LDCM0116  HHS-0101 DM93 Y418(0.65); Y141(0.76); Y29(0.83); Y86(0.86)  LDD0264  [15]
 LDCM0117  HHS-0201 DM93 Y86(0.61); Y418(0.67); Y183(0.73); Y29(0.77)  LDD0265  [15]
 LDCM0118  HHS-0301 DM93 Y85(0.68); Y183(0.72); Y254(0.75); Y29(0.81)  LDD0266  [15]
 LDCM0119  HHS-0401 DM93 Y85(0.72); Y183(0.73); Y141(0.74); Y177(0.80)  LDD0267  [15]
 LDCM0120  HHS-0701 DM93 Y183(0.77); Y29(0.79); Y141(0.80); Y254(0.88)  LDD0268  [15]
 LDCM0015  HNE MDA-MB-231 C411(2.49)  LDD0346  [45]
 LDCM0123  JWB131 DM93 Y141(1.20); Y167(0.78); Y177(0.91); Y183(0.88)  LDD0285  [14]
 LDCM0124  JWB142 DM93 Y141(1.07); Y167(0.41); Y177(0.75); Y183(0.17)  LDD0286  [14]
 LDCM0125  JWB146 DM93 Y141(1.01); Y167(1.00); Y177(0.97); Y183(1.14)  LDD0287  [14]
 LDCM0126  JWB150 DM93 Y141(4.24); Y167(2.94); Y177(2.96); Y183(2.51)  LDD0288  [14]
 LDCM0127  JWB152 DM93 Y141(2.71); Y167(1.61); Y177(1.84); Y183(0.65)  LDD0289  [14]
 LDCM0128  JWB198 DM93 Y141(1.62); Y167(1.06); Y177(1.13); Y183(0.62)  LDD0290  [14]
 LDCM0129  JWB202 DM93 Y141(0.74); Y167(0.32); Y177(0.53); Y183(0.30)  LDD0291  [14]
 LDCM0130  JWB211 DM93 Y141(1.32); Y167(0.69); Y177(0.84); Y183(0.59)  LDD0292  [14]
 LDCM0179  JZ128 PC-3 C411(0.00); C363(0.00); C370(0.00); C234(0.00)  LDD0462  [11]
 LDCM0022  KB02 HCT 116 C411(1.48)  LDD0080  [18]
 LDCM0023  KB03 HCT 116 C411(1.34)  LDD0081  [18]
 LDCM0024  KB05 HCT 116 C411(1.78)  LDD0082  [18]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C411(0.87)  LDD2102  [43]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C411(0.83)  LDD2121  [43]
 LDCM0109  NEM HeLa H295(0.00); H296(0.00)  LDD0224  [17]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C411(0.89)  LDD2089  [43]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C411(1.27)  LDD2090  [43]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C411(0.86)  LDD2092  [43]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C411(1.09)  LDD2093  [43]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C411(1.07)  LDD2094  [43]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C411(0.64)  LDD2096  [43]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C411(1.01)  LDD2097  [43]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C411(1.00)  LDD2098  [43]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C411(1.00)  LDD2099  [43]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C411(1.01)  LDD2100  [43]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C411(0.91)  LDD2101  [43]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C411(0.92); C31(0.91)  LDD2104  [43]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C411(0.73)  LDD2106  [43]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C411(0.98); C31(0.90)  LDD2107  [43]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C411(0.93)  LDD2108  [43]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C411(0.91)  LDD2109  [43]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C411(1.26); C234(0.98)  LDD2110  [43]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C411(1.13)  LDD2111  [43]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C411(0.84); C31(0.92)  LDD2114  [43]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C411(0.67)  LDD2115  [43]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C411(1.15)  LDD2116  [43]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C411(1.22)  LDD2118  [43]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C411(1.40)  LDD2119  [43]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C411(1.03)  LDD2120  [43]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C411(1.00)  LDD2122  [43]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C411(1.01)  LDD2123  [43]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C411(1.12)  LDD2124  [43]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C411(0.97)  LDD2125  [43]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C411(1.30)  LDD2126  [43]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C411(1.26)  LDD2127  [43]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C411(1.03)  LDD2128  [43]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C411(1.00)  LDD2129  [43]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C411(0.58)  LDD2133  [43]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C411(0.57)  LDD2134  [43]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C411(1.18)  LDD2135  [43]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C411(1.31)  LDD2136  [43]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C411(1.04)  LDD2137  [43]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C411(1.72)  LDD1700  [43]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C411(0.96)  LDD2140  [43]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C411(0.97)  LDD2141  [43]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C411(0.95)  LDD2143  [43]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C411(1.39)  LDD2144  [43]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C411(5.54)  LDD2145  [43]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C411(1.09)  LDD2146  [43]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C411(1.57)  LDD2147  [43]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C411(0.59)  LDD2148  [43]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C411(1.19)  LDD2149  [43]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C411(0.77)  LDD2150  [43]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C411(1.22)  LDD2151  [43]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C411(1.75)  LDD2153  [43]
 LDCM0628  OTUB2-COV-1 HEK-293T C363(0.65); C370(0.65); C363(0.13); C370(0.13)  LDD2207  [46]
 LDCM0131  RA190 MM1.R C234(1.21); C411(1.14)  LDD0304  [47]
 LDCM0021  THZ1 HeLa S3 C234(1.06); C411(1.07); C363(1.03); C370(1.04)  LDD0460  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Palmitoyltransferase ZDHHC17 (ZDHHC17) DHHC palmitoyltransferase family Q8IUH5
E3 ubiquitin-protein ligase Mdm2 (MDM2) MDM2/MDM4 family Q00987
Mitogen-activated protein kinase 14 (MAPK14) CMGC Ser/Thr protein kinase family Q16539
Tubulin--tyrosine ligase-like protein 12 (TTLL12) Tubulin--tyrosine ligase family Q14166
Sphingosine kinase 1 (SPHK1) . Q9NYA1
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein zeta/delta (YWHAZ) 14-3-3 family P63104
Bardet-Biedl syndrome 1 protein (BBS1) . Q8NFJ9
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger and BTB domain-containing protein 16 (ZBTB16) Krueppel C2H2-type zinc-finger protein family Q05516
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Proliferating cell nuclear antigen (PCNA) PCNA family P12004
UV excision repair protein RAD23 homolog A (RAD23A) RAD23 family P54725

The Drug(s) Related To This Target

Approved
Click To Hide/Show 6 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Artenimol . DB11638
Copper . DB09130
Zinc . DB01593
Zinc Acetate . DB14487
Zinc Chloride . DB14533
Zinc Sulfate Unspecified Form . DB14548
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Guanosine-5'-diphosphate Small molecular drug DB04315

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos. J Am Chem Soc. 2020 Sep 30;142(39):16825-16841. doi: 10.1021/jacs.0c07726. Epub 2020 Sep 18.
Mass spectrometry data entry: PXD021557 , PXD015828
4 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
5 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
6 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
7 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
8 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
9 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
10 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
11 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
12 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
13 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
14 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
15 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
16 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
17 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
18 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
19 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
20 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
21 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
22 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
23 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
24 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
25 Unveiling the Multifaceted Capabilities of Endophytic Aspergillus flavus Isolated from Annona squamosa Fruit Peels against Staphylococcus Isolates and HCoV 229E-In Vitro and In Silico Investigations. Pharmaceuticals (Basel). 2024 May 19;17(5):656. doi: 10.3390/ph17050656.
Mass spectrometry data entry: PXD013019
26 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
27 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
28 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
29 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
30 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
31 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
32 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
33 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
34 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
35 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
36 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
37 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
38 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
39 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
40 Small Molecule Interactome Mapping by Photoaffinity Labeling Reveals Binding Site Hotspots for the NSAIDs. J Am Chem Soc. 2018 Mar 28;140(12):4259-4268. doi: 10.1021/jacs.7b11639. Epub 2018 Mar 15.
Mass spectrometry data entry: PXD007094
41 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
42 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
43 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
44 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
45 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
46 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
47 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.