Details of the Probe

General Information of Probe

Probe ID
LDPC0003
Probe Name
Alkyne tyramide
Synonyms
Alkyne tyramide; 1694495-59-4; N-[2-(4-hydroxyphenyl)ethyl]pent-4-ynamide; N-(4-Hydroxyphenethyl)pent-4-ynamide; Alkyne-tyramide; SCHEMBL26268646; AKOS040759811; MS-23195; HY-131442; CS-0134719; G17521
Probe Type
ABPP Probe
Structure
3D MOL 2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 217.26
Lipid-water partition coefficient (xlogp) 1.7
Rotatable Bond Count (rotbonds) 5
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 2
Chemical Identifiers
Formula
C13H15NO2
IUPAC Name
N-[2-(4-hydroxyphenyl)ethyl]pent-4-ynamide
Canonical SMILES
C#CCCC(=O)NCCC1=CC=C(C=C1)O
InChI
InChI=1S/C13H15NO2/c1-2-3-4-13(16)14-10-9-11-5-7-12(15)8-6-11/h1,5-8,15H,3-4,9-10H2,(H,14,16)
InChIKey
CQZJBJSXQYZLEX-UHFFFAOYSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

42 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Alpha-enolase (ENO1) LDTP02159 K330; K233  LDD0003 
Alpha-enolase (ENO1) LDTP02159 K330; K233  LDD0003 
Alpha-enolase (ENO1) LDTP02159 K330; K233  LDD0003 
Alpha-enolase (ENO1) LDTP02159 K330; K233  LDD0003 
Citrate synthase, mitochondrial (CS) LDTP01205 Y185; Y345  LDD0003 
Citrate synthase, mitochondrial (CS) LDTP01205 Y185; Y345  LDD0003 
Citrate synthase, mitochondrial (CS) LDTP01205 Y185; Y345  LDD0003 
Citrate synthase, mitochondrial (CS) LDTP01205 Y185; Y345  LDD0003 
Cytochrome b-c1 complex subunit 1, mitochondrial (UQCRC1) LDTP03610 Y123; Y420  LDD0003 
Cytochrome b-c1 complex subunit 1, mitochondrial (UQCRC1) LDTP03610 Y123; Y420  LDD0003 
Cytochrome b-c1 complex subunit 1, mitochondrial (UQCRC1) LDTP03610 Y123; Y420  LDD0003 
Cytochrome b-c1 complex subunit 1, mitochondrial (UQCRC1) LDTP03610 Y123; Y420  LDD0003 
Elongation factor 1-alpha 1 (EEF1A1) LDTP05071 K450; K180  LDD0003 
Elongation factor 1-alpha 1 (EEF1A1) LDTP05071 K450; K180  LDD0003 
Elongation factor 1-alpha 1 (EEF1A1) LDTP05071 K450; K180  LDD0003 
Elongation factor 1-alpha 1 (EEF1A1) LDTP05071 K450; K180  LDD0003 
Elongation factor G, mitochondrial (GFM1) LDTP10774 Y549; Y235  LDD0003 
Elongation factor G, mitochondrial (GFM1) LDTP10774 Y549; Y235  LDD0003 
Elongation factor G, mitochondrial (GFM1) LDTP10774 Y549; Y235  LDD0003 
Elongation factor G, mitochondrial (GFM1) LDTP10774 Y549; Y235  LDD0003 
Elongation factor Tu, mitochondrial (TUFM) LDTP04251 Y360; Y95  LDD0003 
Elongation factor Tu, mitochondrial (TUFM) LDTP04251 Y360; Y95  LDD0003 
Elongation factor Tu, mitochondrial (TUFM) LDTP04251 Y360; Y95  LDD0003 
Elongation factor Tu, mitochondrial (TUFM) LDTP04251 Y360; Y95  LDD0003 
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) LDTP02038 K117; K263  LDD0003 
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) LDTP02038 K117; K263  LDD0003 
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) LDTP02038 K117; K263  LDD0003 
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) LDTP02038 K117; K263  LDD0003 
GTP-binding nuclear protein Ran (RAN) LDTP05007 K37  LDD0003 
GTP-binding nuclear protein Ran (RAN) LDTP05007 K37  LDD0003 
Isoleucine--tRNA ligase, mitochondrial (IARS2) LDTP12588 Y330; Y543; Y993  LDD0003 
Isoleucine--tRNA ligase, mitochondrial (IARS2) LDTP12588 Y330; Y543; Y993  LDD0003 
Isoleucine--tRNA ligase, mitochondrial (IARS2) LDTP12588 Y330; Y543; Y993  LDD0003 
Isoleucine--tRNA ligase, mitochondrial (IARS2) LDTP12588 Y330; Y543; Y993  LDD0003 
Isoleucine--tRNA ligase, mitochondrial (IARS2) LDTP12588 Y330; Y543; Y993  LDD0003 
Isoleucine--tRNA ligase, mitochondrial (IARS2) LDTP12588 Y330; Y543; Y993  LDD0003 
Large ribosomal subunit protein mL39 (MRPL39) LDTP12835 Y235; Y211  LDD0003 
Large ribosomal subunit protein mL39 (MRPL39) LDTP12835 Y235; Y211  LDD0003 
Large ribosomal subunit protein mL39 (MRPL39) LDTP12835 Y235; Y211  LDD0003 
Large ribosomal subunit protein mL39 (MRPL39) LDTP12835 Y235; Y211  LDD0003 
Peptidyl-prolyl cis-trans isomerase A (PPIA) LDTP05028 K44  LDD0003 
Peptidyl-prolyl cis-trans isomerase A (PPIA) LDTP05028 K44  LDD0003 
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⏷ Show the Full List of 42 Enzyme
12 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
ATP synthase subunit O, mitochondrial (ATP5PO) LDTP04150 Y35; Y46  LDD0003 
ATP synthase subunit O, mitochondrial (ATP5PO) LDTP04150 Y35; Y46  LDD0003 
ATP synthase subunit O, mitochondrial (ATP5PO) LDTP04150 Y35; Y46  LDD0003 
ATP synthase subunit O, mitochondrial (ATP5PO) LDTP04150 Y35; Y46  LDD0003 
Mitochondrial 2-oxoglutarate/malate carrier protein (SLC25A11) LDTP05384 Y94; Y259  LDD0003 
Mitochondrial 2-oxoglutarate/malate carrier protein (SLC25A11) LDTP05384 Y94; Y259  LDD0003 
Mitochondrial 2-oxoglutarate/malate carrier protein (SLC25A11) LDTP05384 Y94; Y259  LDD0003 
Mitochondrial 2-oxoglutarate/malate carrier protein (SLC25A11) LDTP05384 Y94; Y259  LDD0003 
Solute carrier family 25 member 3 (SLC25A3) LDTP05238 Y196; Y208  LDD0003 
Solute carrier family 25 member 3 (SLC25A3) LDTP05238 Y196; Y208  LDD0003 
Solute carrier family 25 member 3 (SLC25A3) LDTP05238 Y196; Y208  LDD0003 
Solute carrier family 25 member 3 (SLC25A3) LDTP05238 Y196; Y208  LDD0003 
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⏷ Show the Full List of 12 Transporter and channel
6 Transcription factor Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Transcription factor A, mitochondrial (TFAM) LDTP05235 Y200; Y103; Y162  LDD0003 
Transcription factor A, mitochondrial (TFAM) LDTP05235 Y200; Y103; Y162  LDD0003 
Transcription factor A, mitochondrial (TFAM) LDTP05235 Y200; Y103; Y162  LDD0003 
Transcription factor A, mitochondrial (TFAM) LDTP05235 Y200; Y103; Y162  LDD0003 
Transcription factor A, mitochondrial (TFAM) LDTP05235 Y200; Y103; Y162  LDD0003 
Transcription factor A, mitochondrial (TFAM) LDTP05235 Y200; Y103; Y162  LDD0003 
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⏷ Show the Full List of 6 Transcription factor
42 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
10 kDa heat shock protein, mitochondrial (HSPE1) LDTP04931 Y76; Y88  LDD0003 
10 kDa heat shock protein, mitochondrial (HSPE1) LDTP04931 Y76; Y88  LDD0003 
10 kDa heat shock protein, mitochondrial (HSPE1) LDTP04931 Y76; Y88  LDD0003 
10 kDa heat shock protein, mitochondrial (HSPE1) LDTP04931 Y76; Y88  LDD0003 
Histone H1.4 (H1-4) LDTP02494 K64; K90; K75; K110  LDD0003 
Histone H1.4 (H1-4) LDTP02494 K64; K90; K75; K110  LDD0003 
Histone H1.4 (H1-4) LDTP02494 K64; K90; K75; K110  LDD0003 
Histone H1.4 (H1-4) LDTP02494 K64; K90; K75; K110  LDD0003 
Histone H1.4 (H1-4) LDTP02494 K64; K90; K75; K110  LDD0003 
Histone H1.4 (H1-4) LDTP02494 K64; K90; K75; K110  LDD0003 
Histone H1.4 (H1-4) LDTP02494 K64; K90; K75; K110  LDD0003 
Histone H1.4 (H1-4) LDTP02494 K64; K90; K75; K110  LDD0003 
Histone H2B type 2-F (H2BC18) LDTP07049 K117; K121; K47; K86  LDD0003 
Histone H2B type 2-F (H2BC18) LDTP07049 K117; K121; K47; K86  LDD0003 
Histone H2B type 2-F (H2BC18) LDTP07049 K117; K121; K47; K86  LDD0003 
Histone H2B type 2-F (H2BC18) LDTP07049 K117; K121; K47; K86  LDD0003 
Histone H2B type 2-F (H2BC18) LDTP07049 K117; K121; K47; K86  LDD0003 
Histone H2B type 2-F (H2BC18) LDTP07049 K117; K121; K47; K86  LDD0003 
Histone H2B type 2-F (H2BC18) LDTP07049 K117; K121; K47; K86  LDD0003 
Histone H2B type 2-F (H2BC18) LDTP07049 K117; K121; K47; K86  LDD0003 
Histone H3.3 (H3-3A; H3-3B) LDTP05198 K80; K57  LDD0003 
Histone H3.3 (H3-3A; H3-3B) LDTP05198 K80; K57  LDD0003 
Histone H3.3 (H3-3A; H3-3B) LDTP05198 K80; K57  LDD0003 
Histone H3.3 (H3-3A; H3-3B) LDTP05198 K80; K57  LDD0003 
Single-stranded DNA-binding protein, mitochondrial (SSBP1) LDTP05437 Y119; Y73  LDD0003 
Single-stranded DNA-binding protein, mitochondrial (SSBP1) LDTP05437 Y119; Y73  LDD0003 
Single-stranded DNA-binding protein, mitochondrial (SSBP1) LDTP05437 Y119; Y73  LDD0003 
Single-stranded DNA-binding protein, mitochondrial (SSBP1) LDTP05437 Y119; Y73  LDD0003 
Small ribosomal subunit protein uS17 (RPS11) LDTP04975 K147  LDD0003 
Small ribosomal subunit protein uS17 (RPS11) LDTP04975 K147  LDD0003 
Stress-70 protein, mitochondrial (HSPA9) LDTP03860 Y128; Y652; Y568; Y181  LDD0003 
Stress-70 protein, mitochondrial (HSPA9) LDTP03860 Y128; Y652; Y568; Y181  LDD0003 
Stress-70 protein, mitochondrial (HSPA9) LDTP03860 Y128; Y652; Y568; Y181  LDD0003 
Stress-70 protein, mitochondrial (HSPA9) LDTP03860 Y128; Y652; Y568; Y181  LDD0003 
Stress-70 protein, mitochondrial (HSPA9) LDTP03860 Y128; Y652; Y568; Y181  LDD0003 
Stress-70 protein, mitochondrial (HSPA9) LDTP03860 Y128; Y652; Y568; Y181  LDD0003 
Stress-70 protein, mitochondrial (HSPA9) LDTP03860 Y128; Y652; Y568; Y181  LDD0003 
Stress-70 protein, mitochondrial (HSPA9) LDTP03860 Y128; Y652; Y568; Y181  LDD0003 
Stress-70 protein, mitochondrial (HSPA9) LDTP03860 Y128; Y652; Y568; Y181  LDD0003 
Stress-70 protein, mitochondrial (HSPA9) LDTP03860 Y128; Y652; Y568; Y181  LDD0003 
Transcription elongation regulator 1 (TCERG1) LDTP00430 K703  LDD0003 
Transcription elongation regulator 1 (TCERG1) LDTP00430 K703  LDD0003 
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⏷ Show the Full List of 42 Other

Full Information of The Labelling Profiles of This Probe

Qualitation: Labeling site identification
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
5 mM
Experiment Method
Proximity labeling
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Peripheral blood
Disease Model
Normal
Model Name
Human normal cells (HEK293T-APEX-mito)
Interaction Atlas ID
 LDD0003 
Download The Altas
  
Experiment 2 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
2 mM
Experiment Method
Proximity labeling
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Cervix uteri
Disease Model
Endocervical adenocarcinoma [ICD-11:2C77]
Model Name
Human endocervical adenocarcinoma cells (HeLa)
Interaction Atlas ID
 LDD0012 
Download The Altas

References

1 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764