Details of the Target

General Information of Target

Target ID LDTP02494
Target Name Histone H1.4 (H1-4)
Gene Name H1-4
Gene ID 3008
Synonyms
H1F4; HIST1H1E; Histone H1.4; Histone H1b; Histone H1s-4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSETAPAAPAAPAPAEKTPVKKKARKSAGAAKRKASGPPVSELITKAVAASKERSGVSLA
ALKKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEAKPKA
KKAGAAKAKKPAGAAKKPKKATGAATPKKSAKKTPKKAKKPAAAAGAKKAKSPKKAKAAK
PKKAPKSPAKAKAVKPKAAKPKTAKPKAAKPKKAAAKKK
Target Bioclass
Other
Family
Histone H1/H5 family
Subcellular location
Nucleus
Function
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation.
Uniprot ID
P10412
Ensemble ID
ENST00000304218.6
HGNC ID
HGNC:4718

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y71(8.51)  LDD0260  [1]
C-Sul
 Probe Info  		5.13  LDD0066  [2]
TH216
 Probe Info  		Y71(7.71)  LDD0259  [1]
YN-1
 Probe Info  		100.00  LDD0444  [3]
AZ-9
 Probe Info  		D72(0.95); E42(10.00); E74(10.00)  LDD2208  [4]
ONAyne
 Probe Info  		K160(0.00); K32(0.00); K148(0.00); K140(0.00)  LDD0273  [5]
AMP probe
 Probe Info  		K75(0.00); K90(0.00); K34(0.00)  LDD0200  [6]
ATP probe
 Probe Info  		K75(0.00); K90(0.00); K34(0.00); K64(0.00)  LDD0199  [6]
CY-1
 Probe Info  		N.A.  LDD0246  [7]
Alkyne tyramide
 Probe Info  		K64(0.00); K90(0.00); K75(0.00); K110(0.00)  LDD0003  [8]
2PCA
 Probe Info  		K110(0.00); K85(0.00)  LDD0034  [9]
aONE
 Probe Info  		N.A.  LDD0002  [8]
NHS
 Probe Info  		K34(0.00); K75(0.00); K97(0.00); K46(0.00)  LDD0010  [8]
SF
 Probe Info  		K136(0.00); K32(0.00); K90(0.00); K119(0.00)  LDD0028  [10]
STPyne
 Probe Info  		K46(0.00); K106(0.00); K90(0.00); K64(0.00)  LDD0009  [8]
1c-yne
 Probe Info  		N.A.  LDD0228  [11]
W1
 Probe Info  		K63(0.00); K64(0.00); S58(0.00); S89(0.00)  LDD0236  [12]
HHS-475
 Probe Info  		Y71(0.86)  LDD2238  [13]
HHS-482
 Probe Info  		Y71(0.91)  LDD2239  [13]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Diazir
 Probe Info  		N.A.  LDD0011  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0110  W12 Hep-G2 E53(0.58)  LDD0237  [12]
 LDCM0111  W14 Hep-G2 K90(0.50); K63(0.58)  LDD0238  [12]
 LDCM0113  W17 Hep-G2 K63(0.51); K90(0.53); S89(0.53)  LDD0240  [12]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 (FTSJ3) RNA methyltransferase RlmE family Q8IY81
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1) . Q9Y468
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
SH2/SH3 adapter protein NCK1 (NCK1) . P16333

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Copper . DB09130

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Unveiling the Multifaceted Capabilities of Endophytic Aspergillus flavus Isolated from Annona squamosa Fruit Peels against Staphylococcus Isolates and HCoV 229E-In Vitro and In Silico Investigations. Pharmaceuticals (Basel). 2024 May 19;17(5):656. doi: 10.3390/ph17050656.
Mass spectrometry data entry: PXD013019
10 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
11 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
12 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
13 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.