Details of the Competitor

General Information of Competitor

Competitor ID
LDCM0113
Competitor Name
W17
Synonyms
(E)-4-Chloronicotinaldehyde oxime; 471909-43-0; (NE)-N-[(4-chloropyridin-3-yl)methylidene]hydroxylamine; (E)-N-[(4-chloropyridin-3-yl)methylidene]hydroxylamine; SCHEMBL1982833; (E)-4-Chloronicotinaldehydeoxime; WTA90943; MFCD12922730; AKOS006337023; (E)-4-Chloronicotinaldehyde oxime, AldrichCPR; A923083
Structure
3D MOL 2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 156.57
Lipid-water partition coefficient (xlogp) 1.2
Rotatable Bond Count (rotbonds) 1
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 3
Chemical Identifiers
Formula
C6H5ClN2O
IUPAC Name
(NE)-N-[(4-chloropyridin-3-yl)methylidene]hydroxylamine
Canonical SMILES
C1=CN=CC(=C1Cl)C=NO
InChI
InChI=1S/C6H5ClN2O/c7-6-1-2-8-3-5(6)4-9-10/h1-4,10H/b9-4+
InChIKey
MKJYDOKLIMMJDA-RUDMXATFSA-N

The Competitor Interaction Atlas

Probe(s) Related This Competitor

ABPP Probe
Click To Hide/Show 1 Probe Related to This Competitor
Probe Name Structure Concentration Cell-system Ref
W1
 Probe Info  		500 uM Human hepatoblastoma cells (Hep-G2) [1]

Target(s) List of this Competitor

79 Enzyme Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
60 kDa heat shock protein, mitochondrial (HSPD1) LDTP02522 1.11  LDD0240 
Actin, alpha skeletal muscle (ACTA1) LDTP05073 1.75  LDD0240 
Actin, cytoplasmic 2 (ACTG1) LDTP05059 0.56; 0.86; 1.90 ...  LDD0240 
Acyl-coenzyme A thioesterase 1 (ACOT1) LDTP08209 6.30  LDD0240 
Adenosine deaminase (ADA) LDTP01803 7.38  LDD0240 
Aldo-keto reductase family 1 member C2 (AKR1C2) LDTP04543 0.60; 0.60; 1.24 ...  LDD0240 
Aldo-keto reductase family 1 member C3 (AKR1C3) LDTP03976 1.24; 1.24; 1.30 ...  LDD0240 
Alpha-enolase (ENO1) LDTP02159 1.19; 1.47; 1.96  LDD0240 
Aspartate--tRNA ligase, cytoplasmic (DARS1) LDTP02752 0.51; 1.67  LDD0240 
ATP-dependent RNA helicase DDX19A (DDX19A) LDTP12646 5.07  LDD0240 
Cancer-related nucleoside-triphosphatase (NTPCR) LDTP11152 6.55  LDD0240 
Carbonyl reductase [NADPH] 1 (CBR1) LDTP02831 30.91  LDD0240 
Catalase (CAT) LDTP02001 1.17  LDD0240 
Catechol O-methyltransferase (COMT) LDTP03145 2.41  LDD0240 
D-3-phosphoglycerate dehydrogenase (PHGDH) LDTP00701 2.22; 2.22  LDD0240 
dCTP pyrophosphatase 1 (DCTPP1) LDTP12013 1.51; 1.51  LDD0240 
Dehydrogenase/reductase SDR family member 2, mitochondrial (DHRS2) LDTP05809 0.51; 13.46; 13.84  LDD0240 
Delta-1-pyrroline-5-carboxylate synthase (ALDH18A1) LDTP04646 6.55  LDD0240 
Dihydropyrimidinase-related protein 5 (DPYSL5) LDTP11035 1.53  LDD0240 
DNA replication licensing factor MCM3 (MCM3) LDTP03316 7.69  LDD0240 
DNA-dependent protein kinase catalytic subunit (PRKDC) LDTP05136 3.28; 23.46  LDD0240 
Elongation factor 2 (EEF2) LDTP02672 4.85  LDD0240 
Eukaryotic initiation factor 4A-I (EIF4A1) LDTP04878 0.96; 0.96  LDD0240 
Fatty acid synthase (FASN) LDTP04243 0.50; 0.70; 1.73 ...  LDD0240 
Fructosamine-3-kinase (FN3K) LDTP11904 15.07  LDD0240 
Fructose-bisphosphate aldolase A (ALDOA) LDTP02008 0.78; 0.78; 0.78  LDD0240 
Glutamate dehydrogenase 1, mitochondrial (GLUD1) LDTP01768 0.94  LDD0240 
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 (GFPT1) LDTP05481 1.47; 2.46  LDD0240 
Glutathione S-transferase omega-1 (GSTO1) LDTP05128 0.59; 1.14; 14.00  LDD0240 
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) LDTP02038 0.51; 0.99; 27.97  LDD0240 
Guanidino acid hydrolase, mitochondrial (AGMAT) LDTP15873 0.85  LDD0240 
Heat shock protein HSP 90-alpha (HSP90AA1) LDTP02225 0.55; 0.55; 1.00 ...  LDD0240 
Heme oxygenase 2 (HMOX2) LDTP03540 10.52  LDD0240 
Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) LDTP01333 0.79  LDD0240 
Large ribosomal subunit protein mL44 (MRPL44) LDTP12098 9.43  LDD0240 
Macrophage migration inhibitory factor (MIF) LDTP02713 8.49  LDD0240 
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (MCCC2) LDTP12227 5.34  LDD0240 
Microsomal glutathione S-transferase 1 (MGST1) LDTP02506 2.08  LDD0240 
Mitochondrial-processing peptidase subunit beta (PMPCB) LDTP01220 13.89; 14.30  LDD0240 
Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L) LDTP07651 6.09  LDD0240 
NAD(P)H dehydrogenase [quinone] 1 (NQO1) LDTP02798 0.91; 0.91  LDD0240 
NADH-ubiquinone oxidoreductase chain 3 (MT-ND3) LDTP01984 0.63  LDD0240 
NADPH--cytochrome P450 reductase (POR) LDTP02848 10.99  LDD0240 
Nucleoside diphosphate kinase A (NME1) LDTP02796 0.55; 0.55  LDD0240 
Nucleoside diphosphate kinase B (NME2) LDTP03169 0.99  LDD0240 
Peroxiredoxin-1 (PRDX1) LDTP05503 32.27; 32.89  LDD0240 
Peroxiredoxin-5, mitochondrial (PRDX5) LDTP03512 2.32  LDD0240 
Peroxiredoxin-6 (PRDX6) LDTP03510 0.63; 0.64; 2.79  LDD0240 
Phosphoenolpyruvate carboxykinase [GTP], mitochondrial (PCK2) LDTP06638 0.63; 0.84; 5.18  LDD0240 
Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase (NOP2) LDTP04084 0.60  LDD0240 
Probable ATP-dependent RNA helicase DDX5 (DDX5) LDTP02924 0.68  LDD0240 
Prostaglandin E synthase 3 (PTGES3) LDTP06338 11.83; 12.18  LDD0240 
Protein disulfide-isomerase (P4HB) LDTP02188 0.59; 0.59; 0.97 ...  LDD0240 
Protein disulfide-isomerase A4 (PDIA4) LDTP02677 1.82  LDD0240 
Putative elongation factor 1-alpha-like 3 (EEF1A1P5) LDTP15029 0.63; 0.92  LDD0240 
Pyruvate carboxylase, mitochondrial (PC) LDTP02576 16.62  LDD0240 
Pyruvate kinase PKM (PKM) LDTP02733 0.63  LDD0240 
Rho-associated protein kinase 2 (ROCK2) LDTP01127 8.60  LDD0240 
Ribosomal biogenesis protein LAS1L (LAS1L) LDTP14074 6.63  LDD0240 
Ribosomal protein S6 kinase alpha-3 (RPS6KA3) LDTP04471 7.19  LDD0240 
Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) LDTP15484 11.76  LDD0240 
Septin-9 (SEPTIN9) LDTP13272 1.16  LDD0240 
Serine/threonine-protein phosphatase CPPED1 (CPPED1) LDTP11107 30.73  LDD0240 
Small ribosomal subunit protein uS3 (RPS3) LDTP03223 2.64  LDD0240 
SNF-related serine/threonine-protein kinase (SNRK) LDTP12511 5.81  LDD0240 
Squalene synthase (FDFT1) LDTP03842 2.07  LDD0240 
Sulfotransferase 1A1 (SULT1A1) LDTP04349 29.94  LDD0240 
Thioredoxin domain-containing protein 12 (TXNDC12) LDTP01707 3.29  LDD0240 
Thioredoxin domain-containing protein 5 (TXNDC5) LDTP09067 17.28  LDD0240 
Thioredoxin-dependent peroxide reductase, mitochondrial (PRDX3) LDTP03515 9.54; 17.95  LDD0240 
Transitional endoplasmic reticulum ATPase (VCP) LDTP04665 0.78; 0.98; 0.98  LDD0240 
Tubulin alpha-1B chain (TUBA1B) LDTP05074 0.67; 1.07  LDD0240 
Tubulin alpha-1C chain (TUBA1C) LDTP11074 0.93  LDD0240 
U5 small nuclear ribonucleoprotein 200 kDa helicase (SNRNP200) LDTP01283 1.47  LDD0240 
Ubiquitin carboxyl-terminal hydrolase 48 (USP48) LDTP08254 4.13  LDD0240 
Ubiquitin-conjugating enzyme E2 D4 (UBE2D4) LDTP13927 2.37  LDD0240 
Ubiquitin-like modifier-activating enzyme 1 (UBA1) LDTP03166 3.83  LDD0240 
V-type proton ATPase catalytic subunit A (ATP6V1A) LDTP03859 13.28  LDD0240 
X-ray repair cross-complementing protein 5 (XRCC5) LDTP02642 13.89  LDD0240 
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⏷ Show the Full List of 79 Enzyme
27 Transporter and channel Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
14-3-3 protein theta (YWHAQ) LDTP03385 1.05; 1.05; 1.22 ...  LDD0240 
14-3-3 protein zeta/delta (YWHAZ) LDTP05043 1.04; 1.04; 1.04  LDD0240 
ADP/ATP translocase 2 (SLC25A5) LDTP02087 0.64  LDD0240 
Annexin A5 (ANXA5) LDTP02307 0.61  LDD0240 
ATP synthase subunit alpha, mitochondrial (ATP5F1A) LDTP03327 0.56; 0.56; 0.57 ...  LDD0240 
Autophagy-related protein 9A (ATG9A) LDTP08030 1.23  LDD0240 
Calnexin (CANX) LDTP03405 0.57; 0.57  LDD0240 
Chloride intracellular channel protein 1 (CLIC1) LDTP00244 14.45  LDD0240 
Chloride intracellular channel protein 4 (CLIC4) LDTP14222 15.94  LDD0240 
Clathrin heavy chain 1 (CLTC) LDTP05252 12.81; 13.63  LDD0240 
Cysteine protease ATG4B (ATG4B) LDTP14068 9.46  LDD0240 
Exportin-2 (CSE1L) LDTP04662 1.70  LDD0240 
Exportin-5 (XPO5) LDTP12142 1.22  LDD0240 
Filamin-A (FLNA) LDTP03107 11.69  LDD0240 
Heat shock protein HSP 90-beta (HSP90AB1) LDTP02262 0.63; 1.15  LDD0240 
Membrane-associated progesterone receptor component 1 (PGRMC1) LDTP00235 2.46  LDD0240 
Protein SEC13 homolog (SEC13) LDTP04707 2.12  LDD0240 
Protein transport protein Sec61 subunit beta (SEC61B) LDTP04866 5.71  LDD0240 
Signal recognition particle 9 kDa protein (SRP9) LDTP04259 0.69; 0.69  LDD0240 
Signal recognition particle subunit SRP68 (SRP68) LDTP13262 2.09  LDD0240 
Small ribosomal subunit protein RACK1 (RACK1) LDTP05057 1.46  LDD0240 
Spectrin beta chain, non-erythrocytic 1 (SPTBN1) LDTP05273 5.84  LDD0240 
Surfeit locus protein 4 (SURF4) LDTP00592 1.00; 1.00  LDD0240 
Thioredoxin domain-containing protein 17 (TXNDC17) LDTP11103 6.54  LDD0240 
Transmembrane 9 superfamily member 3 (TM9SF3) LDTP18448 0.77  LDD0240 
Voltage-dependent anion-selective channel protein 1 (VDAC1) LDTP03132 1.06  LDD0240 
Voltage-dependent anion-selective channel protein 3 (VDAC3) LDTP13824 12.01  LDD0240 
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⏷ Show the Full List of 27 Transporter and channel
3 Transcription factor Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
FACT complex subunit SSRP1 (SSRP1) LDTP05577 0.72  LDD0240 
General transcription factor II-I (GTF2I) LDTP05101 6.36  LDD0240 
Paternally-expressed gene 3 protein (PEG3) LDTP11651 10.91  LDD0240 
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77 Other Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
Acyl-CoA-binding protein (DBI) LDTP02177 3.42; 3.42  LDD0240 
Alpha-1-antitrypsin (SERPINA1) LDTP01811 0.82; 0.88  LDD0240 
Alpha-actinin-4 (ACTN4) LDTP00843 3.08  LDD0240 
Arf-GAP domain and FG repeat-containing protein 2 (AGFG2) LDTP16839 0.88  LDD0240 
CCHC-type zinc finger nucleic acid binding protein (CNBP) LDTP04995 0.53  LDD0240 
Centromere protein F (CENPF) LDTP04258 1.10  LDD0240 
Cofilin-1 (CFL1) LDTP03244 13.91  LDD0240 
Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1) LDTP06083 5.47  LDD0240 
Exosome complex component RRP40 (EXOSC3) LDTP12434 7.39  LDD0240 
Fatty acid-binding protein, liver (FABP1) LDTP02178 6.53  LDD0240 
Glypican-3 (GPC3) LDTP04439 0.57; 0.58; 5.48  LDD0240 
Golgi to ER traffic protein 4 homolog (GET4) LDTP07964 8.05  LDD0240 
Heat shock protein 75 kDa, mitochondrial (TRAP1) LDTP05697 23.44  LDD0240 
Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1) LDTP02364 67.95  LDD0240 
Heterogeneous nuclear ribonucleoprotein A1-like 2 (HNRNPA1L2) LDTP17097 0.64  LDD0240 
Heterogeneous nuclear ribonucleoprotein F (HNRNPF) LDTP04514 9.02  LDD0240 
Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) LDTP03615 12.55  LDD0240 
Heterogeneous nuclear ribonucleoprotein M (HNRNPM) LDTP04500 0.71; 1.45  LDD0240 
Heterogeneous nuclear ribonucleoprotein R (HNRNPR) LDTP00756 4.86  LDD0240 
Histone H1.4 (H1-4) LDTP02494 0.51; 0.53; 0.53  LDD0240 
Histone H2A type 1-C (H2AC6) LDTP09974 0.58; 1.39  LDD0240 
Histone H2A.V (H2AZ2) LDTP07908 0.93  LDD0240 
Histone H2B type 1-C/E/F/G/I (H2BC4; H2BC6; H2BC7; H2BC8; H2BC10) LDTP05005 0.68; 1.25; 1.25 ...  LDD0240 
Histone H2B type 1-L (H2BC13) LDTP11001 0.55; 1.35; 1.38 ...  LDD0240 
Histone H3.2 (H3C15; H3C14; H3C13) LDTP07899 0.56; 1.02; 1.06 ...  LDD0240 
Histone H4 (H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16) LDTP05004 0.88; 0.88; 1.01 ...  LDD0240 
Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) LDTP00272 1.52; 1.54  LDD0240 
Ladinin-1 (LAD1) LDTP14421 12.29  LDD0240 
Lamina-associated polypeptide 2, isoform alpha (TMPO) LDTP03967 6.83  LDD0240 
Large ribosomal subunit protein eL13 (RPL13) LDTP03354 0.59; 0.62  LDD0240 
Large ribosomal subunit protein eL18 (RPL18) LDTP05509 0.56; 0.73  LDD0240 
Large ribosomal subunit protein eL20 (RPL18A) LDTP05360 0.66; 0.66  LDD0240 
Large ribosomal subunit protein eL22 (RPL22) LDTP03728 0.57  LDD0240 
Large ribosomal subunit protein eL34 (RPL34) LDTP04233 0.96; 16.23  LDD0240 
Large ribosomal subunit protein uL3 (RPL3) LDTP03865 0.71; 0.71  LDD0240 
Large ribosomal subunit protein uL30 (RPL7) LDTP02944 0.58; 0.61; 0.61  LDD0240 
LIM domain-containing protein ajuba (AJUBA) LDTP10416 3.55  LDD0240 
Lipase maturation factor 2 (LMF2) LDTP15887 2.67  LDD0240 
Lipoma-preferred partner (LPP) LDTP09969 2.87  LDD0240 
Lupus La protein (SSB) LDTP02116 19.31  LDD0240 
MMS19 nucleotide excision repair protein homolog (MMS19) LDTP10843 3.27  LDD0240 
Mucin-2 (MUC2) LDTP05374 1.42  LDD0240 
Nucleolar complex protein 2 homolog (NOC2L) LDTP14011 13.56  LDD0240 
Nucleolar protein 58 (NOP58) LDTP13925 13.81  LDD0240 
Nucleolin (NCL) LDTP02990 3.23  LDD0240 
Nucleophosmin (NPM1) LDTP02164 1.10; 1.10  LDD0240 
Perilipin-3 (PLIN3) LDTP01021 5.18  LDD0240 
Poly(rC)-binding protein 1 (PCBP1) LDTP06366 3.85; 7.44  LDD0240 
Poly(rC)-binding protein 2 (PCBP2) LDTP06367 3.31  LDD0240 
Polyadenylate-binding protein 1 (PABPC1) LDTP02595 11.84  LDD0240 
Prelamin-A/C (LMNA) LDTP01932 2.47; 6.40  LDD0240 
Profilin-1 (PFN1) LDTP02218 0.63  LDD0240 
Protein THEM6 (THEM6) LDTP19831 4.19; 19.44  LDD0240 
Receptor expression-enhancing protein 5 (REEP5) LDTP05257 8.75  LDD0240 
Reticulon-4 (RTN4) LDTP12412 8.42; 8.50  LDD0240 
Ribosomal L1 domain-containing protein 1 (RSL1D1) LDTP01379 2.37; 2.60  LDD0240 
Ribosomal protein eL42-like (RPL36AL) LDTP15677 1.45  LDD0240 
RNA transcription, translation and transport factor protein (RTRAF) LDTP13782 9.03  LDD0240 
RRP12-like protein (RRP12) LDTP14980 3.22  LDD0240 
Serine/arginine-rich splicing factor 3 (SRSF3) LDTP05197 4.46  LDD0240 
Serotransferrin (TF) LDTP01970 6.47  LDD0240 
Small ribosomal subunit protein eS12 (RPS12) LDTP03321 1.81; 1.81  LDD0240 
Small ribosomal subunit protein eS8 (RPS8) LDTP04964 0.58; 4.21  LDD0240 
Small ribosomal subunit protein uS4 (RPS9) LDTP04109 0.50; 0.50; 0.53  LDD0240 
Small ribosomal subunit protein uS5 (RPS2) LDTP02809 0.55; 0.55  LDD0240 
Small ribosomal subunit protein uS7 (RPS5) LDTP04110 0.95  LDD0240 
Small ribosomal subunit protein uS9 (RPS16) LDTP04966 0.68; 0.68; 0.68  LDD0240 
SPATS2-like protein (SPATS2L) LDTP16102 5.25  LDD0240 
Spectrin alpha chain, non-erythrocytic 1 (SPTAN1) LDTP05985 1.18  LDD0240 
Src substrate cortactin (CTTN) LDTP06094 26.47  LDD0240 
Stress-70 protein, mitochondrial (HSPA9) LDTP03860 1.05  LDD0240 
Stress-induced-phosphoprotein 1 (STIP1) LDTP03619 1.23; 1.23  LDD0240 
T-complex protein 1 subunit eta (CCT7) LDTP10990 0.54; 0.56  LDD0240 
T-complex protein 1 subunit theta (CCT8) LDTP04390 1.72  LDD0240 
TAR DNA-binding protein 43 (TARDBP) LDTP05767 1.38  LDD0240 
Ubiquitin-ribosomal protein eS31 fusion protein (RPS27A) LDTP05033 1.28  LDD0240 
Visinin-like protein 1 (VSNL1) LDTP05003 3.55  LDD0240 
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⏷ Show the Full List of 77 Other

Full Information of The Labelling Profiles of This Competitor

Quantification: Probe vs (Probe+Competitor)
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration 500 uM
Quantitative Method SILAC
Competitor Name W17
Competitor Concentration 500 uM
In Vitro Experiment Model Model Type
Living cell
Derived Tissue
Liver
Disease Model Hepatoblastoma [ICD-11:DB91]
Model Name Human hepatoblastoma cells (Hep-G2)
Interaction Atlas ID  LDD0240  Download The Altas

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.