Details of the Target

General Information of Target

Target ID LDTP03244
Target Name Cofilin-1 (CFL1)
Gene Name CFL1
Gene ID 1072
Synonyms
CFL; Cofilin-1; 18 kDa phosphoprotein; p18; Cofilin, non-muscle isoform
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASGVAVSDGVIKVFNDMKVRKSSTPEEVKKRKKAVLFCLSEDKKNIILEEGKEILVGDV
GQTVDDPYATFVKMLPDKDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASS
KDAIKKKLTGIKHELQANCYEEVKDRCTLAEKLGGSAVISLEGKPL
Target Bioclass
Other
Family
Actin-binding proteins ADF family
Subcellular location
Nucleus matrix
Function
Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. In conjunction with the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics. Required for the centralization of the mitotic spindle and symmetric division of zygotes. Plays a role in the regulation of cell morphology and cytoskeletal organization in epithelial cells. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. Required for neural tube morphogenesis and neural crest cell migration.
Uniprot ID
P23528
Ensemble ID
ENST00000308162.10
HGNC ID
HGNC:1874
ChEMBL ID
CHEMBL1075129

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 65 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
P2
 Probe Info  		1.59  LDD0449  [2]
P3
 Probe Info  		1.85  LDD0450  [2]
P8
 Probe Info  		4.24  LDD0451  [2]
A-EBA
 Probe Info  		5.24  LDD0215  [3]
8RK64
 Probe Info  		N.A.  LDD0039  [4]
AZ-9
 Probe Info  		2.17  LDD0393  [5]
DAyne
 Probe Info  		4.74  LDD0261  [6]
CY-1
 Probe Info  		100.00  LDD0243  [7]
CY4
 Probe Info  		14.29  LDD0244  [7]
N1
 Probe Info  		10.84  LDD0242  [7]
TH211
 Probe Info  		Y117(20.00); Y82(20.00); Y89(20.00); Y140(11.91)  LDD0257  [8]
TH214
 Probe Info  		Y117(20.00); Y82(20.00); Y140(15.20); Y85(14.77)  LDD0258  [8]
TH216
 Probe Info  		Y82(20.00); Y85(18.25); Y140(16.76)  LDD0259  [8]
ONAyne
 Probe Info  		N.A.  LDD0273  [9]
OPA-S-S-alkyne
 Probe Info  		K78(1.62); K19(2.23); K144(3.15); K164(4.91)  LDD3494  [10]
Probe 1
 Probe Info  		Y68(15.24); Y82(18.75); Y85(138.84); Y89(88.35)  LDD3495  [11]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [12]
AHL-Pu-1
 Probe Info  		C147(2.02)  LDD0169  [13]
EA-probe
 Probe Info  		C139(0.94); C139(0.88)  LDD2210  [14]
HHS-482
 Probe Info  		Y117(0.97); Y140(1.06); Y68(1.13); Y82(1.16)  LDD0285  [15]
HHS-475
 Probe Info  		Y89(0.77); Y140(0.86)  LDD0264  [16]
HHS-465
 Probe Info  		Y117(10.00); Y68(10.00); Y82(10.00); Y85(10.00)  LDD2237  [17]
DBIA
 Probe Info  		C39(1.27); C139(1.88)  LDD0080  [18]
5E-2FA
 Probe Info  		N.A.  LDD2235  [19]
AMP probe
 Probe Info  		K144(0.00); K132(0.00)  LDD0200  [20]
ATP probe
 Probe Info  		K144(0.00); K132(0.00); K112(0.00); K114(0.00)  LDD0199  [20]
4-Iodoacetamidophenylacetylene
 Probe Info  		C39(0.00); C147(0.00); C139(0.00); C80(0.00)  LDD0038  [21]
IA-alkyne
 Probe Info  		C39(0.00); C139(0.00); C80(0.00)  LDD0032  [22]
IPIAA_H
 Probe Info  		C147(0.00); C139(0.00); C39(0.00); C80(0.00)  LDD0030  [23]
IPIAA_L
 Probe Info  		C39(0.00); C147(0.00); C80(0.00); C139(0.00)  LDD0031  [23]
Lodoacetamide azide
 Probe Info  		C39(0.00); C139(0.00); C80(0.00); C147(0.00)  LDD0037  [21]
2PCA
 Probe Info  		N.A.  LDD0034  [24]
ATP probe
 Probe Info  		K121(0.00); K22(0.00); K31(0.00); K92(0.00)  LDD0035  [25]
BTD
 Probe Info  		C139(0.00); C80(0.00); C147(0.00)  LDD0004  [26]
Dyn-2
 Probe Info  		N.A.  LDD0013  [26]
JW-RF-010
 Probe Info  		C139(0.00); C147(0.00); C39(0.00); C80(0.00)  LDD0026  [27]
NAIA_4
 Probe Info  		C39(0.00); C139(0.00)  LDD2226  [28]
TFBX
 Probe Info  		C80(0.00); C147(0.00)  LDD0027  [27]
WYneC
 Probe Info  		N.A.  LDD0014  [26]
WYneN
 Probe Info  		C39(0.00); C139(0.00); C147(0.00)  LDD0021  [26]
WYneO
 Probe Info  		C139(0.00); C39(0.00)  LDD0022  [26]
aHNE
 Probe Info  		N.A.  LDD0001  [26]
1d-yne
 Probe Info  		K164(0.00); K53(0.00)  LDD0356  [29]
Compound 10
 Probe Info  		C139(0.00); C39(0.00)  LDD2216  [30]
Compound 11
 Probe Info  		N.A.  LDD2213  [30]
ENE
 Probe Info  		N.A.  LDD0006  [26]
IPM
 Probe Info  		C39(0.00); C147(0.00); C139(0.00)  LDD0005  [26]
NHS
 Probe Info  		K121(0.00); K92(0.00); K22(0.00); K19(0.00)  LDD0010  [26]
NPM
 Probe Info  		N.A.  LDD0016  [26]
PF-06672131
 Probe Info  		C39(0.00); C139(0.00)  LDD0017  [31]
SF
 Probe Info  		K30(0.00); K114(0.00); K22(0.00); Y89(0.00)  LDD0028  [32]
STPyne
 Probe Info  		K132(0.00); K144(0.00); K92(0.00)  LDD0009  [26]
VSF
 Probe Info  		N.A.  LDD0007  [26]
YN-1
 Probe Info  		N.A.  LDD0446  [33]
Phosphinate-6
 Probe Info  		C147(0.00); C80(0.00); C139(0.00); C39(0.00)  LDD0018  [34]
Ox-W18
 Probe Info  		N.A.  LDD2175  [35]
1c-yne
 Probe Info  		K144(0.00); K132(0.00); K13(0.00); K112(0.00)  LDD0228  [29]
Acrolein
 Probe Info  		C139(0.00); H133(0.00); K132(0.00); C39(0.00)  LDD0217  [36]
Crotonaldehyde
 Probe Info  		C139(0.00); C39(0.00); C80(0.00); K78(0.00)  LDD0219  [36]
Methacrolein
 Probe Info  		C139(0.00); C39(0.00); C80(0.00); H133(0.00)  LDD0218  [36]
W1
 Probe Info  		N.A.  LDD0236  [37]
AOyne
 Probe Info  		15.00  LDD0443  [38]
NAIA_5
 Probe Info  		C39(0.00); C147(0.00); C139(0.00); C80(0.00)  LDD2223  [28]
TER-AC
 Probe Info  		N.A.  LDD0426  [39]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-2
 Probe Info  		N.A.  LDD0138  [40]
CR-1
 Probe Info  		2.58  LDD0429  [41]
STS-1
 Probe Info  		N.A.  LDD0068  [42]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C147(0.85); C139(0.75); C39(0.59); C80(0.38)  LDD2142  [43]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C147(0.99); C139(0.89); C39(0.85); C80(0.54)  LDD2112  [43]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C147(0.74); C139(0.63); C39(0.63); C80(0.61)  LDD2095  [43]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C147(0.94); C139(0.92); C39(1.02); C80(1.04)  LDD2130  [43]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C147(0.96); C139(1.04); C39(1.37); C80(1.13)  LDD2117  [43]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C147(1.10); C139(1.27); C39(1.37); C80(1.27)  LDD2152  [43]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C147(0.71); C139(0.96); C39(1.28); C80(1.24)  LDD2103  [43]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C147(0.55); C139(0.76); C39(0.58); C80(0.51)  LDD2132  [43]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C147(0.55); C139(0.88); C39(0.82); C80(0.73)  LDD2131  [43]
 LDCM0025  4SU-RNA DM93 C80(3.79)  LDD0170  [13]
 LDCM0026  4SU-RNA+native RNA HEK-293T C147(2.02)  LDD0169  [13]
 LDCM0214  AC1 HCT 116 C139(1.17); C39(1.02)  LDD0531  [18]
 LDCM0215  AC10 HCT 116 C139(1.17); C39(0.84)  LDD0532  [18]
 LDCM0216  AC100 HCT 116 C139(1.02); C39(0.77)  LDD0533  [18]
 LDCM0217  AC101 HCT 116 C139(1.02); C39(0.80)  LDD0534  [18]
 LDCM0218  AC102 HCT 116 C139(0.98); C39(0.90)  LDD0535  [18]
 LDCM0219  AC103 HCT 116 C139(1.24); C39(0.77)  LDD0536  [18]
 LDCM0220  AC104 HCT 116 C139(1.13); C39(0.78)  LDD0537  [18]
 LDCM0221  AC105 HCT 116 C139(1.13); C39(0.89)  LDD0538  [18]
 LDCM0222  AC106 HCT 116 C139(1.18); C39(0.77)  LDD0539  [18]
 LDCM0223  AC107 HCT 116 C139(1.21); C39(1.18)  LDD0540  [18]
 LDCM0224  AC108 HCT 116 C139(1.09); C39(0.95)  LDD0541  [18]
 LDCM0225  AC109 HCT 116 C139(0.87); C39(0.89)  LDD0542  [18]
 LDCM0226  AC11 HCT 116 C139(1.31); C39(0.89)  LDD0543  [18]
 LDCM0227  AC110 HCT 116 C139(0.83); C39(0.82)  LDD0544  [18]
 LDCM0228  AC111 HCT 116 C139(0.99); C39(0.82)  LDD0545  [18]
 LDCM0229  AC112 HCT 116 C139(1.03); C39(0.93)  LDD0546  [18]
 LDCM0230  AC113 HCT 116 C139(1.04); C147(0.76); C39(1.27)  LDD0547  [18]
 LDCM0231  AC114 HCT 116 C139(1.17); C147(0.84); C39(1.34)  LDD0548  [18]
 LDCM0232  AC115 HCT 116 C139(1.23); C147(0.75); C39(1.17)  LDD0549  [18]
 LDCM0233  AC116 HCT 116 C139(1.32); C147(0.40); C39(1.01)  LDD0550  [18]
 LDCM0234  AC117 HCT 116 C139(1.16); C147(0.35); C39(1.11)  LDD0551  [18]
 LDCM0235  AC118 HCT 116 C139(1.20); C147(0.31); C39(1.03)  LDD0552  [18]
 LDCM0236  AC119 HCT 116 C139(1.15); C147(0.23); C39(0.97)  LDD0553  [18]
 LDCM0237  AC12 HCT 116 C139(1.13); C39(0.91)  LDD0554  [18]
 LDCM0238  AC120 HCT 116 C139(1.14); C147(0.86); C39(1.14)  LDD0555  [18]
 LDCM0239  AC121 HCT 116 C139(1.05); C147(0.87); C39(1.01)  LDD0556  [18]
 LDCM0240  AC122 HCT 116 C139(1.08); C147(0.23); C39(1.10)  LDD0557  [18]
 LDCM0241  AC123 HCT 116 C139(1.01); C147(0.73); C39(1.08)  LDD0558  [18]
 LDCM0242  AC124 HCT 116 C139(1.05); C147(0.50); C39(1.12)  LDD0559  [18]
 LDCM0243  AC125 HCT 116 C139(1.11); C147(0.66); C39(1.23)  LDD0560  [18]
 LDCM0244  AC126 HCT 116 C139(1.26); C147(0.74); C39(1.15)  LDD0561  [18]
 LDCM0245  AC127 HCT 116 C139(1.25); C147(0.25); C39(1.01)  LDD0562  [18]
 LDCM0246  AC128 HCT 116 C139(1.24); C39(1.00)  LDD0563  [18]
 LDCM0247  AC129 HCT 116 C139(1.24); C39(1.05)  LDD0564  [18]
 LDCM0249  AC130 HCT 116 C139(1.45); C39(0.94)  LDD0566  [18]
 LDCM0250  AC131 HCT 116 C139(1.03); C39(0.99)  LDD0567  [18]
 LDCM0251  AC132 HCT 116 C139(1.15); C39(1.14)  LDD0568  [18]
 LDCM0252  AC133 HCT 116 C139(1.24); C39(1.05)  LDD0569  [18]
 LDCM0253  AC134 HCT 116 C139(1.34); C39(1.02)  LDD0570  [18]
 LDCM0254  AC135 HCT 116 C139(1.34); C39(0.90)  LDD0571  [18]
 LDCM0255  AC136 HCT 116 C139(1.22); C39(0.95)  LDD0572  [18]
 LDCM0256  AC137 HCT 116 C139(1.11); C39(1.13)  LDD0573  [18]
 LDCM0257  AC138 HCT 116 C139(1.62); C39(0.94)  LDD0574  [18]
 LDCM0258  AC139 HCT 116 C139(1.27); C39(0.99)  LDD0575  [18]
 LDCM0259  AC14 HCT 116 C139(1.07); C39(1.22)  LDD0576  [18]
 LDCM0260  AC140 HCT 116 C139(1.42); C39(0.99)  LDD0577  [18]
 LDCM0261  AC141 HCT 116 C139(1.40); C39(0.99)  LDD0578  [18]
 LDCM0262  AC142 HCT 116 C139(1.11); C39(0.82)  LDD0579  [18]
 LDCM0263  AC143 HCT 116 C139(1.14); C147(0.98); C39(0.83)  LDD0580  [18]
 LDCM0264  AC144 HCT 116 C39(0.95); C147(1.11); C139(1.42)  LDD0581  [18]
 LDCM0265  AC145 HCT 116 C147(1.22); C139(1.22); C39(1.42)  LDD0582  [18]
 LDCM0266  AC146 HCT 116 C139(1.25); C147(1.30); C39(1.49)  LDD0583  [18]
 LDCM0267  AC147 HCT 116 C39(1.28); C139(1.30); C147(1.41)  LDD0584  [18]
 LDCM0268  AC148 HCT 116 C39(0.74); C147(1.08); C139(1.73)  LDD0585  [18]
 LDCM0269  AC149 HCT 116 C39(0.91); C147(1.24); C139(1.38)  LDD0586  [18]
 LDCM0270  AC15 HCT 116 C139(1.18); C39(1.27)  LDD0587  [18]
 LDCM0271  AC150 HCT 116 C139(1.10); C39(1.21); C147(1.42)  LDD0588  [18]
 LDCM0272  AC151 HCT 116 C147(0.45); C39(0.87); C139(1.06)  LDD0589  [18]
 LDCM0273  AC152 HCT 116 C39(1.05); C147(1.23); C139(1.29)  LDD0590  [18]
 LDCM0274  AC153 HCT 116 C39(0.62); C147(1.02); C139(1.94)  LDD0591  [18]
 LDCM0621  AC154 HCT 116 C139(1.20); C147(1.16); C39(1.98)  LDD2158  [18]
 LDCM0622  AC155 HCT 116 C139(1.09); C147(0.55); C39(0.98)  LDD2159  [18]
 LDCM0623  AC156 HCT 116 C139(0.99); C147(1.17); C39(0.74)  LDD2160  [18]
 LDCM0624  AC157 HCT 116 C139(0.96); C147(1.21); C39(0.83)  LDD2161  [18]
 LDCM0276  AC17 HCT 116 C39(0.89); C139(1.06)  LDD0593  [18]
 LDCM0277  AC18 HCT 116 C39(1.17); C139(1.48)  LDD0594  [18]
 LDCM0278  AC19 HCT 116 C39(0.87); C139(1.04)  LDD0595  [18]
 LDCM0279  AC2 HCT 116 C39(1.05); C139(1.05)  LDD0596  [18]
 LDCM0280  AC20 HCT 116 C39(0.84); C139(1.16)  LDD0597  [18]
 LDCM0281  AC21 HCT 116 C39(0.79); C139(1.24)  LDD0598  [18]
 LDCM0282  AC22 HCT 116 C39(0.83); C139(1.12)  LDD0599  [18]
 LDCM0283  AC23 HCT 116 C39(0.89); C139(1.16)  LDD0600  [18]
 LDCM0284  AC24 HCT 116 C139(0.94); C39(1.12)  LDD0601  [18]
 LDCM0285  AC25 HCT 116 C147(0.72); C39(0.95); C139(1.14)  LDD0602  [18]
 LDCM0286  AC26 HCT 116 C147(0.42); C39(1.03); C139(1.30)  LDD0603  [18]
 LDCM0287  AC27 HCT 116 C147(0.85); C39(1.00); C139(1.23)  LDD0604  [18]
 LDCM0288  AC28 HCT 116 C147(0.13); C39(0.83); C139(1.11)  LDD0605  [18]
 LDCM0289  AC29 HCT 116 C147(1.09); C139(1.19); C39(1.20)  LDD0606  [18]
 LDCM0290  AC3 HCT 116 C39(1.04); C139(1.05)  LDD0607  [18]
 LDCM0291  AC30 HCT 116 C39(1.03); C147(1.04); C139(1.20)  LDD0608  [18]
 LDCM0292  AC31 HCT 116 C147(0.64); C39(1.06); C139(1.24)  LDD0609  [18]
 LDCM0293  AC32 HCT 116 C147(0.38); C39(1.02); C139(1.62)  LDD0610  [18]
 LDCM0294  AC33 HCT 116 C147(0.78); C39(1.15); C139(1.36)  LDD0611  [18]
 LDCM0295  AC34 HCT 116 C39(0.93); C147(1.12); C139(1.49)  LDD0612  [18]
 LDCM0296  AC35 HCT 116 C139(0.70)  LDD0613  [18]
 LDCM0297  AC36 HCT 116 C139(1.04)  LDD0614  [18]
 LDCM0298  AC37 HCT 116 C139(0.98)  LDD0615  [18]
 LDCM0299  AC38 HCT 116 C139(0.93)  LDD0616  [18]
 LDCM0300  AC39 HCT 116 C139(1.01)  LDD0617  [18]
 LDCM0301  AC4 HCT 116 C39(1.12); C139(1.21)  LDD0618  [18]
 LDCM0302  AC40 HCT 116 C139(1.13)  LDD0619  [18]
 LDCM0303  AC41 HCT 116 C139(1.06)  LDD0620  [18]
 LDCM0304  AC42 HCT 116 C139(0.96)  LDD0621  [18]
 LDCM0305  AC43 HCT 116 C139(1.08)  LDD0622  [18]
 LDCM0306  AC44 HCT 116 C139(1.01)  LDD0623  [18]
 LDCM0307  AC45 HCT 116 C139(1.14)  LDD0624  [18]
 LDCM0308  AC46 HCT 116 C139(1.09); C39(1.10)  LDD0625  [18]
 LDCM0309  AC47 HCT 116 C39(0.98); C139(1.16)  LDD0626  [18]
 LDCM0310  AC48 HCT 116 C39(1.05); C139(1.10)  LDD0627  [18]
 LDCM0311  AC49 HCT 116 C39(0.87); C139(1.31)  LDD0628  [18]
 LDCM0312  AC5 HCT 116 C39(1.03); C139(1.23)  LDD0629  [18]
 LDCM0313  AC50 HCT 116 C39(1.09); C139(1.22)  LDD0630  [18]
 LDCM0314  AC51 HCT 116 C139(0.90); C39(1.17)  LDD0631  [18]
 LDCM0315  AC52 HCT 116 C39(1.04); C139(1.10)  LDD0632  [18]
 LDCM0316  AC53 HCT 116 C139(1.00); C39(1.10)  LDD0633  [18]
 LDCM0317  AC54 HCT 116 C39(1.03); C139(1.08)  LDD0634  [18]
 LDCM0318  AC55 HCT 116 C39(0.94); C139(1.29)  LDD0635  [18]
 LDCM0319  AC56 HCT 116 C39(0.83); C139(2.01)  LDD0636  [18]
 LDCM0320  AC57 HCT 116 C147(0.45); C39(1.04); C139(1.45)  LDD0637  [18]
 LDCM0321  AC58 HCT 116 C147(0.72); C39(1.12); C139(1.41)  LDD0638  [18]
 LDCM0322  AC59 HCT 116 C147(0.41); C39(0.98); C139(1.41)  LDD0639  [18]
 LDCM0323  AC6 HCT 116 C39(1.04); C139(1.31)  LDD0640  [18]
 LDCM0324  AC60 HCT 116 C147(0.44); C39(1.03); C139(1.44)  LDD0641  [18]
 LDCM0325  AC61 HCT 116 C147(0.24); C39(0.95); C139(1.37)  LDD0642  [18]
 LDCM0326  AC62 HCT 116 C147(0.28); C39(1.02); C139(1.76)  LDD0643  [18]
 LDCM0327  AC63 HCT 116 C147(0.22); C39(0.88); C139(1.49)  LDD0644  [18]
 LDCM0328  AC64 HCT 116 C147(0.29); C39(0.92); C139(1.36)  LDD0645  [18]
 LDCM0329  AC65 HCT 116 C147(0.33); C39(0.99); C139(1.53)  LDD0646  [18]
 LDCM0330  AC66 HCT 116 C147(0.37); C39(0.89); C139(1.41)  LDD0647  [18]
 LDCM0331  AC67 HCT 116 C147(0.26); C39(0.74); C139(1.70)  LDD0648  [18]
 LDCM0332  AC68 HCT 116 C39(1.04); C139(1.15)  LDD0649  [18]
 LDCM0333  AC69 HCT 116 C39(0.87); C139(1.33)  LDD0650  [18]
 LDCM0334  AC7 HCT 116 C39(0.90); C139(1.21)  LDD0651  [18]
 LDCM0335  AC70 HCT 116 C39(0.80); C139(1.53)  LDD0652  [18]
 LDCM0336  AC71 HCT 116 C39(1.09); C139(1.13)  LDD0653  [18]
 LDCM0337  AC72 HCT 116 C39(0.88); C139(1.21)  LDD0654  [18]
 LDCM0338  AC73 HCT 116 C39(0.72); C139(1.61)  LDD0655  [18]
 LDCM0339  AC74 HCT 116 C39(0.71); C139(1.72)  LDD0656  [18]
 LDCM0340  AC75 HCT 116 C39(0.58); C139(2.13)  LDD0657  [18]
 LDCM0341  AC76 HCT 116 C39(0.87); C139(1.56)  LDD0658  [18]
 LDCM0342  AC77 HCT 116 C39(0.90); C139(1.82)  LDD0659  [18]
 LDCM0343  AC78 HCT 116 C39(0.80); C139(1.26)  LDD0660  [18]
 LDCM0344  AC79 HCT 116 C39(0.89); C139(1.19)  LDD0661  [18]
 LDCM0345  AC8 HCT 116 C39(1.01); C139(1.38)  LDD0662  [18]
 LDCM0346  AC80 HCT 116 C39(0.87); C139(1.41)  LDD0663  [18]
 LDCM0347  AC81 HCT 116 C39(0.76); C139(2.01)  LDD0664  [18]
 LDCM0348  AC82 HCT 116 C39(0.50); C139(3.96)  LDD0665  [18]
 LDCM0349  AC83 HCT 116 C39(0.98); C139(1.53)  LDD0666  [18]
 LDCM0350  AC84 HCT 116 C139(1.13); C39(1.15)  LDD0667  [18]
 LDCM0351  AC85 HCT 116 C39(1.09); C139(1.41)  LDD0668  [18]
 LDCM0352  AC86 HCT 116 C39(1.21); C139(1.31)  LDD0669  [18]
 LDCM0353  AC87 HCT 116 C39(1.01); C139(1.07)  LDD0670  [18]
 LDCM0354  AC88 HCT 116 C139(0.99); C39(1.44)  LDD0671  [18]
 LDCM0355  AC89 HCT 116 C39(1.28); C139(1.48)  LDD0672  [18]
 LDCM0357  AC90 HCT 116 C39(0.80); C139(1.03)  LDD0674  [18]
 LDCM0358  AC91 HCT 116 C39(1.08); C139(1.37)  LDD0675  [18]
 LDCM0359  AC92 HCT 116 C139(1.19); C39(1.23)  LDD0676  [18]
 LDCM0360  AC93 HCT 116 C139(1.05); C39(1.20)  LDD0677  [18]
 LDCM0361  AC94 HCT 116 C139(1.02); C39(1.34)  LDD0678  [18]
 LDCM0362  AC95 HCT 116 C39(1.06); C139(1.07)  LDD0679  [18]
 LDCM0363  AC96 HCT 116 C39(1.04); C139(1.29)  LDD0680  [18]
 LDCM0364  AC97 HCT 116 C39(1.00); C139(1.36)  LDD0681  [18]
 LDCM0365  AC98 HCT 116 C39(0.52); C139(2.34)  LDD0682  [18]
 LDCM0366  AC99 HCT 116 C39(0.79); C139(0.94)  LDD0683  [18]
 LDCM0545  Acetamide MDA-MB-231 C147(0.24); C139(0.42); C39(0.79); C80(0.59)  LDD2138  [43]
 LDCM0520  AKOS000195272 MDA-MB-231 C147(0.60); C139(0.75); C80(0.71)  LDD2113  [43]
 LDCM0248  AKOS034007472 HCT 116 C139(0.94); C39(0.93)  LDD0565  [18]
 LDCM0356  AKOS034007680 HCT 116 C39(0.95); C139(1.26)  LDD0673  [18]
 LDCM0275  AKOS034007705 HCT 116 C39(1.08); C139(1.65)  LDD0592  [18]
 LDCM0156  Aniline NCI-H1299 13.15  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C139(1.16); C39(1.23)  LDD2171  [18]
 LDCM0498  BS-3668 MDA-MB-231 C147(0.36); C139(0.56); C39(0.88); C80(0.73)  LDD2091  [43]
 LDCM0108  Chloroacetamide HeLa C139(0.00); C39(0.00); C80(0.00); C147(0.00)  LDD0222  [36]
 LDCM0632  CL-Sc Hep-G2 C139(20.00); C80(20.00); C147(2.68); C147(2.39)  LDD2227  [28]
 LDCM0367  CL1 HCT 116 C39(0.86); C139(0.93)  LDD0684  [18]
 LDCM0368  CL10 HCT 116 C39(0.86); C139(1.26)  LDD0685  [18]
 LDCM0369  CL100 HCT 116 C39(1.01); C139(1.17)  LDD0686  [18]
 LDCM0370  CL101 HCT 116 C39(1.06); C139(1.31)  LDD0687  [18]
 LDCM0371  CL102 HCT 116 C39(0.82); C139(1.06)  LDD0688  [18]
 LDCM0372  CL103 HCT 116 C139(1.05); C39(1.09)  LDD0689  [18]
 LDCM0373  CL104 HCT 116 C139(1.04); C39(1.05)  LDD0690  [18]
 LDCM0374  CL105 HCT 116 C39(0.72); C139(0.90)  LDD0691  [18]
 LDCM0375  CL106 HCT 116 C39(0.87); C139(1.85)  LDD0692  [18]
 LDCM0376  CL107 HCT 116 C39(0.98); C139(1.65)  LDD0693  [18]
 LDCM0377  CL108 HCT 116 C39(0.94); C139(1.48)  LDD0694  [18]
 LDCM0378  CL109 HCT 116 C39(0.87); C139(1.23)  LDD0695  [18]
 LDCM0379  CL11 HCT 116 C39(0.87); C139(1.41)  LDD0696  [18]
 LDCM0380  CL110 HCT 116 C39(0.76); C139(1.39)  LDD0697  [18]
 LDCM0381  CL111 HCT 116 C39(0.82); C139(1.26)  LDD0698  [18]
 LDCM0382  CL112 HCT 116 C39(0.96); C139(1.03); C147(1.15)  LDD0699  [18]
 LDCM0383  CL113 HCT 116 C39(0.97); C147(1.21); C139(1.57)  LDD0700  [18]
 LDCM0384  CL114 HCT 116 C39(0.92); C147(1.30); C139(1.51)  LDD0701  [18]
 LDCM0385  CL115 HCT 116 C39(1.06); C147(1.18); C139(1.32)  LDD0702  [18]
 LDCM0386  CL116 HCT 116 C147(0.68); C39(0.94); C139(1.23)  LDD0703  [18]
 LDCM0387  CL117 HCT 116 C139(1.49)  LDD0704  [18]
 LDCM0388  CL118 HCT 116 C139(1.02)  LDD0705  [18]
 LDCM0389  CL119 HCT 116 C139(1.07)  LDD0706  [18]
 LDCM0390  CL12 HCT 116 C39(0.93); C139(1.37)  LDD0707  [18]
 LDCM0391  CL120 HCT 116 C139(0.96)  LDD0708  [18]
 LDCM0392  CL121 HCT 116 C139(0.83); C39(1.25)  LDD0709  [18]
 LDCM0393  CL122 HCT 116 C39(0.96); C139(1.25)  LDD0710  [18]
 LDCM0394  CL123 HCT 116 C39(0.83); C139(1.09)  LDD0711  [18]
 LDCM0395  CL124 HCT 116 C39(0.91); C139(1.18)  LDD0712  [18]
 LDCM0396  CL125 HCT 116 C147(0.37); C139(0.83); C39(0.87)  LDD0713  [18]
 LDCM0397  CL126 HCT 116 C147(0.56); C39(1.10); C139(1.20)  LDD0714  [18]
 LDCM0398  CL127 HCT 116 C147(0.55); C39(1.02); C139(1.25)  LDD0715  [18]
 LDCM0399  CL128 HCT 116 C147(0.45); C39(1.02); C139(1.27)  LDD0716  [18]
 LDCM0400  CL13 HCT 116 C39(1.01); C139(1.13)  LDD0717  [18]
 LDCM0401  CL14 HCT 116 C139(1.00); C39(1.02)  LDD0718  [18]
 LDCM0402  CL15 HCT 116 C39(0.50); C139(1.15)  LDD0719  [18]
 LDCM0403  CL16 HCT 116 C39(1.03); C139(1.04)  LDD0720  [18]
 LDCM0404  CL17 HCT 116 C39(0.82); C139(1.09)  LDD0721  [18]
 LDCM0405  CL18 HCT 116 C139(1.08); C39(1.11)  LDD0722  [18]
 LDCM0406  CL19 HCT 116 C39(0.94); C139(1.13)  LDD0723  [18]
 LDCM0407  CL2 HCT 116 C39(0.99); C139(1.07)  LDD0724  [18]
 LDCM0408  CL20 HCT 116 C39(1.07); C139(1.21)  LDD0725  [18]
 LDCM0409  CL21 HCT 116 C39(0.76); C139(1.22)  LDD0726  [18]
 LDCM0410  CL22 HCT 116 C39(0.79); C139(1.59)  LDD0727  [18]
 LDCM0411  CL23 HCT 116 C139(0.92); C39(1.21)  LDD0728  [18]
 LDCM0412  CL24 HCT 116 C39(1.13); C139(1.24)  LDD0729  [18]
 LDCM0413  CL25 HCT 116 C139(1.12); C39(0.95)  LDD0730  [18]
 LDCM0414  CL26 HCT 116 C139(0.95); C39(0.97)  LDD0731  [18]
 LDCM0415  CL27 HCT 116 C139(1.00); C39(0.99)  LDD0732  [18]
 LDCM0416  CL28 HCT 116 C139(1.15); C39(0.92)  LDD0733  [18]
 LDCM0417  CL29 HCT 116 C139(1.10); C39(0.93)  LDD0734  [18]
 LDCM0418  CL3 HCT 116 C139(1.04); C39(1.05)  LDD0735  [18]
 LDCM0419  CL30 HCT 116 C139(0.73); C39(1.06)  LDD0736  [18]
 LDCM0420  CL31 HCT 116 C139(1.08); C39(1.18)  LDD0737  [18]
 LDCM0421  CL32 HCT 116 C139(1.28); C39(1.17)  LDD0738  [18]
 LDCM0422  CL33 HCT 116 C139(1.24); C39(1.02)  LDD0739  [18]
 LDCM0423  CL34 HCT 116 C139(1.30); C39(1.13)  LDD0740  [18]
 LDCM0424  CL35 HCT 116 C139(1.31); C39(1.45)  LDD0741  [18]
 LDCM0425  CL36 HCT 116 C139(1.59); C39(1.49)  LDD0742  [18]
 LDCM0426  CL37 HCT 116 C139(2.15); C39(1.45)  LDD0743  [18]
 LDCM0428  CL39 HCT 116 C139(1.61); C39(1.10)  LDD0745  [18]
 LDCM0429  CL4 HCT 116 C139(0.96); C39(1.03)  LDD0746  [18]
 LDCM0430  CL40 HCT 116 C139(1.23); C39(1.26)  LDD0747  [18]
 LDCM0431  CL41 HCT 116 C139(1.35); C39(1.70)  LDD0748  [18]
 LDCM0432  CL42 HCT 116 C139(2.15); C39(0.99)  LDD0749  [18]
 LDCM0433  CL43 HCT 116 C139(1.47); C39(1.28)  LDD0750  [18]
 LDCM0434  CL44 HCT 116 C139(1.20); C39(1.23)  LDD0751  [18]
 LDCM0435  CL45 HCT 116 C139(1.35); C39(1.17)  LDD0752  [18]
 LDCM0436  CL46 HCT 116 C139(0.84); C39(0.80)  LDD0753  [18]
 LDCM0437  CL47 HCT 116 C139(0.92); C39(0.94)  LDD0754  [18]
 LDCM0438  CL48 HCT 116 C139(0.93); C39(1.08)  LDD0755  [18]
 LDCM0439  CL49 HCT 116 C139(0.86); C39(1.08)  LDD0756  [18]
 LDCM0440  CL5 HCT 116 C139(1.02); C39(0.96)  LDD0757  [18]
 LDCM0441  CL50 HCT 116 C139(0.88); C39(1.07)  LDD0758  [18]
 LDCM0442  CL51 HCT 116 C139(0.87); C39(1.05)  LDD0759  [18]
 LDCM0443  CL52 HCT 116 C139(0.95); C39(0.96)  LDD0760  [18]
 LDCM0444  CL53 HCT 116 C139(0.94); C39(1.12)  LDD0761  [18]
 LDCM0445  CL54 HCT 116 C139(0.84); C39(1.32)  LDD0762  [18]
 LDCM0446  CL55 HCT 116 C139(0.87); C39(1.15)  LDD0763  [18]
 LDCM0447  CL56 HCT 116 C139(1.04); C39(0.94)  LDD0764  [18]
 LDCM0448  CL57 HCT 116 C139(0.88); C39(1.38)  LDD0765  [18]
 LDCM0449  CL58 HCT 116 C139(0.82); C39(0.95)  LDD0766  [18]
 LDCM0450  CL59 HCT 116 C139(0.83); C39(1.01)  LDD0767  [18]
 LDCM0451  CL6 HCT 116 C139(1.14); C39(0.81)  LDD0768  [18]
 LDCM0452  CL60 HCT 116 C139(0.83); C39(1.04)  LDD0769  [18]
 LDCM0453  CL61 HCT 116 C139(1.13); C39(1.11)  LDD0770  [18]
 LDCM0454  CL62 HCT 116 C139(1.13); C39(1.22)  LDD0771  [18]
 LDCM0455  CL63 HCT 116 C139(1.23); C39(1.16)  LDD0772  [18]
 LDCM0456  CL64 HCT 116 C139(1.26); C39(1.09)  LDD0773  [18]
 LDCM0457  CL65 HCT 116 C139(1.09); C39(1.17)  LDD0774  [18]
 LDCM0458  CL66 HCT 116 C139(1.46); C39(1.15)  LDD0775  [18]
 LDCM0459  CL67 HCT 116 C139(1.18); C39(1.48)  LDD0776  [18]
 LDCM0460  CL68 HCT 116 C139(1.36); C39(1.39)  LDD0777  [18]
 LDCM0461  CL69 HCT 116 C139(1.13); C39(0.96)  LDD0778  [18]
 LDCM0462  CL7 HCT 116 C139(1.04); C39(0.89)  LDD0779  [18]
 LDCM0463  CL70 HCT 116 C139(1.11); C39(1.21)  LDD0780  [18]
 LDCM0464  CL71 HCT 116 C139(1.25); C39(1.00)  LDD0781  [18]
 LDCM0465  CL72 HCT 116 C139(1.05); C39(1.01)  LDD0782  [18]
 LDCM0466  CL73 HCT 116 C139(1.09); C39(1.15)  LDD0783  [18]
 LDCM0467  CL74 HCT 116 C139(1.15); C39(1.28)  LDD0784  [18]
 LDCM0469  CL76 HCT 116 C139(1.17); C39(1.38)  LDD0786  [18]
 LDCM0470  CL77 HCT 116 C139(1.21); C39(1.28)  LDD0787  [18]
 LDCM0471  CL78 HCT 116 C139(1.24); C39(1.37)  LDD0788  [18]
 LDCM0472  CL79 HCT 116 C139(1.28); C39(1.08)  LDD0789  [18]
 LDCM0473  CL8 HCT 116 C139(1.43); C39(0.74)  LDD0790  [18]
 LDCM0474  CL80 HCT 116 C139(1.18); C39(1.38)  LDD0791  [18]
 LDCM0475  CL81 HCT 116 C139(1.12); C39(1.18)  LDD0792  [18]
 LDCM0476  CL82 HCT 116 C139(1.50); C39(1.23)  LDD0793  [18]
 LDCM0477  CL83 HCT 116 C139(1.52); C39(1.27)  LDD0794  [18]
 LDCM0478  CL84 HCT 116 C139(2.11); C39(1.19)  LDD0795  [18]
 LDCM0479  CL85 HCT 116 C139(1.27); C39(1.43)  LDD0796  [18]
 LDCM0480  CL86 HCT 116 C139(1.14); C39(1.01)  LDD0797  [18]
 LDCM0481  CL87 HCT 116 C139(1.17); C39(1.37)  LDD0798  [18]
 LDCM0482  CL88 HCT 116 C139(1.32); C39(1.03)  LDD0799  [18]
 LDCM0483  CL89 HCT 116 C139(2.45); C39(1.26)  LDD0800  [18]
 LDCM0484  CL9 HCT 116 C139(1.21); C39(0.98)  LDD0801  [18]
 LDCM0485  CL90 HCT 116 C139(0.89); C39(1.17)  LDD0802  [18]
 LDCM0486  CL91 HCT 116 C139(1.21); C39(1.05)  LDD0803  [18]
 LDCM0487  CL92 HCT 116 C139(1.24); C39(0.76)  LDD0804  [18]
 LDCM0488  CL93 HCT 116 C139(1.13); C39(0.79)  LDD0805  [18]
 LDCM0489  CL94 HCT 116 C139(1.25); C39(1.01)  LDD0806  [18]
 LDCM0490  CL95 HCT 116 C139(1.32); C39(0.89)  LDD0807  [18]
 LDCM0491  CL96 HCT 116 C139(1.18); C39(0.91)  LDD0808  [18]
 LDCM0492  CL97 HCT 116 C139(1.17); C39(0.92)  LDD0809  [18]
 LDCM0493  CL98 HCT 116 C139(1.26); C39(1.10)  LDD0810  [18]
 LDCM0494  CL99 HCT 116 C139(1.21); C39(1.10)  LDD0811  [18]
 LDCM0168  Crenolanib NCI-H1703 2.58  LDD0429  [41]
 LDCM0634  CY-0357 Hep-G2 C147(1.24); C139(1.00); C139(0.89); C39(0.50)  LDD2228  [28]
 LDCM0495  E2913 HEK-293T C139(1.04); C80(1.09); C39(0.78)  LDD1698  [44]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C147(1.34); C139(0.95); C39(0.78); C80(0.67)  LDD1702  [43]
 LDCM0175  Ethacrynic acid HeLa C139(0.94); C139(0.88)  LDD2210  [14]
 LDCM0625  F8 Ramos C80(0.94); C39(1.09); C139(4.94); C147(1.35)  LDD2187  [45]
 LDCM0572  Fragment10 MDA-MB-231 C80(0.78)  LDD1389  [46]
 LDCM0573  Fragment11 MDA-MB-231 C80(0.86)  LDD1391  [46]
 LDCM0574  Fragment12 Ramos C80(0.46)  LDD1394  [46]
 LDCM0575  Fragment13 MDA-MB-231 C80(0.86)  LDD1395  [46]
 LDCM0576  Fragment14 MDA-MB-231 C80(0.94)  LDD1397  [46]
 LDCM0577  Fragment15 Ramos C80(0.78)  LDD1400  [46]
 LDCM0579  Fragment20 MDA-MB-231 C80(1.01)  LDD1402  [46]
 LDCM0580  Fragment21 MDA-MB-231 C80(0.81)  LDD1404  [46]
 LDCM0581  Fragment22 MDA-MB-231 C80(0.96)  LDD1406  [46]
 LDCM0582  Fragment23 MDA-MB-231 C80(20.00)  LDD1408  [46]
 LDCM0584  Fragment25 MDA-MB-231 C80(0.87)  LDD1411  [46]
 LDCM0585  Fragment26 Ramos C80(0.70)  LDD1412  [46]
 LDCM0578  Fragment27 MDA-MB-231 C80(1.44)  LDD1401  [46]
 LDCM0586  Fragment28 MDA-MB-231 C80(0.78)  LDD1415  [46]
 LDCM0587  Fragment29 MDA-MB-231 C80(0.84)  LDD1417  [46]
 LDCM0588  Fragment30 MDA-MB-231 C80(0.66)  LDD1419  [46]
 LDCM0589  Fragment31 MDA-MB-231 C80(0.97)  LDD1421  [46]
 LDCM0590  Fragment32 MDA-MB-231 C80(0.69)  LDD1423  [46]
 LDCM0468  Fragment33 HCT 116 C139(1.16); C39(1.34)  LDD0785  [18]
 LDCM0596  Fragment38 MDA-MB-231 C80(1.14)  LDD1433  [46]
 LDCM0597  Fragment39 MDA-MB-231 C80(0.69)  LDD1435  [46]
 LDCM0566  Fragment4 MDA-MB-231 C80(0.70)  LDD1378  [46]
 LDCM0598  Fragment40 MDA-MB-231 C80(0.70)  LDD1436  [46]
 LDCM0601  Fragment43 MDA-MB-231 C80(0.69)  LDD1441  [46]
 LDCM0603  Fragment45 MDA-MB-231 C80(0.69)  LDD1444  [46]
 LDCM0604  Fragment46 MDA-MB-231 C80(0.84)  LDD1445  [46]
 LDCM0605  Fragment47 MDA-MB-231 C80(0.86)  LDD1446  [46]
 LDCM0606  Fragment48 MDA-MB-231 C80(0.87)  LDD1447  [46]
 LDCM0607  Fragment49 MDA-MB-231 C80(0.36)  LDD1448  [46]
 LDCM0608  Fragment50 MDA-MB-231 C80(0.70)  LDD1449  [46]
 LDCM0427  Fragment51 HCT 116 C139(1.52); C39(1.07)  LDD0744  [18]
 LDCM0610  Fragment52 MDA-MB-231 C80(0.65)  LDD1452  [46]
 LDCM0611  Fragment53 Ramos C80(1.37)  LDD1455  [46]
 LDCM0614  Fragment56 MDA-MB-231 C80(0.77)  LDD1458  [46]
 LDCM0568  Fragment6 MDA-MB-231 C80(2.54)  LDD1382  [46]
 LDCM0569  Fragment7 Ramos C80(0.69)  LDD1384  [46]
 LDCM0570  Fragment8 MDA-MB-231 C80(0.94)  LDD1385  [46]
 LDCM0571  Fragment9 MDA-MB-231 C80(0.55)  LDD1387  [46]
 LDCM0116  HHS-0101 DM93 Y89(0.77); Y140(0.86)  LDD0264  [16]
 LDCM0117  HHS-0201 DM93 Y140(0.65); Y89(0.83)  LDD0265  [16]
 LDCM0118  HHS-0301 DM93 Y89(0.88); Y140(1.01)  LDD0266  [16]
 LDCM0119  HHS-0401 DM93 Y89(0.71); Y140(0.73)  LDD0267  [16]
 LDCM0120  HHS-0701 DM93 Y89(0.70); Y140(0.71)  LDD0268  [16]
 LDCM0107  IAA HeLa H133(0.00); C39(0.00); C80(0.00); K132(0.00)  LDD0221  [36]
 LDCM0123  JWB131 DM93 Y117(0.97); Y140(1.06); Y68(1.13); Y82(1.16)  LDD0285  [15]
 LDCM0124  JWB142 DM93 Y117(0.77); Y140(0.85); Y68(1.27); Y82(0.75)  LDD0286  [15]
 LDCM0125  JWB146 DM93 Y117(0.75); Y140(0.92); Y68(0.97); Y82(0.90)  LDD0287  [15]
 LDCM0126  JWB150 DM93 Y117(4.03); Y140(4.86); Y68(3.35); Y82(6.15)  LDD0288  [15]
 LDCM0127  JWB152 DM93 Y117(1.58); Y140(2.46); Y68(1.95); Y82(2.89)  LDD0289  [15]
 LDCM0128  JWB198 DM93 Y117(1.65); Y140(1.77); Y68(1.14); Y82(3.52)  LDD0290  [15]
 LDCM0129  JWB202 DM93 Y117(0.92); Y140(0.95); Y68(0.86); Y82(0.99)  LDD0291  [15]
 LDCM0130  JWB211 DM93 Y117(1.10); Y140(1.13); Y68(0.75); Y82(1.13)  LDD0292  [15]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [12]
 LDCM0022  KB02 HCT 116 C39(1.27); C139(1.88)  LDD0080  [18]
 LDCM0023  KB03 HCT 116 C39(1.16); C139(1.17)  LDD0081  [18]
 LDCM0024  KB05 HCT 116 C39(1.53); C139(1.12)  LDD0082  [18]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C147(0.76); C139(0.96); C39(1.19); C80(1.33)  LDD2102  [43]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C147(0.35); C139(0.57); C39(0.95); C80(0.79)  LDD2121  [43]
 LDCM0109  NEM HeLa H133(0.00); C139(0.00); C80(0.00)  LDD0223  [36]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C147(0.33); C139(0.66); C39(1.01); C80(0.80)  LDD2089  [43]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C147(0.87); C139(1.18); C39(1.16); C80(1.05)  LDD2090  [43]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C147(0.69); C139(0.91); C39(1.10); C80(1.49)  LDD2092  [43]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C147(0.73); C139(0.95); C39(1.41); C80(0.97)  LDD2093  [43]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C147(0.87); C139(1.44); C39(2.20); C80(3.04)  LDD2094  [43]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C147(1.23); C139(0.95); C39(0.76); C80(0.12)  LDD2096  [43]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C147(0.98); C139(1.08); C39(0.72); C80(0.79)  LDD2097  [43]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C147(0.86); C139(0.92); C80(0.52)  LDD2098  [43]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C147(0.66); C139(0.99); C39(1.40); C80(1.06)  LDD2099  [43]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C147(1.18); C139(0.95); C39(0.70); C80(0.35)  LDD2100  [43]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C147(0.42); C139(1.03); C80(0.98)  LDD2101  [43]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C147(1.05); C139(0.87); C39(0.54); C80(0.66)  LDD2104  [43]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C147(0.97); C139(1.19); C39(2.11); C80(1.88)  LDD2105  [43]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C147(0.92); C139(0.72); C39(0.85); C80(0.70)  LDD2106  [43]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C147(0.83); C139(1.04); C39(1.15); C80(0.99)  LDD2107  [43]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C147(0.99); C139(0.75); C39(0.80); C80(0.34)  LDD2108  [43]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C147(0.70); C139(0.84); C39(0.66); C80(0.57)  LDD2109  [43]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C147(2.00); C139(1.18); C39(0.87); C80(1.26)  LDD2110  [43]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C147(0.76); C139(1.00); C39(1.05); C80(1.01)  LDD2111  [43]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C147(0.94); C139(0.72); C39(0.65); C80(1.11)  LDD2114  [43]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C147(0.46); C139(0.47); C39(0.12); C80(0.46)  LDD2115  [43]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C147(0.95); C139(0.85); C39(0.85); C80(0.26)  LDD2116  [43]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C147(1.83); C139(0.78); C39(1.01); C80(0.19)  LDD2118  [43]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C147(2.57); C139(2.19); C39(1.80); C80(2.14)  LDD2119  [43]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C147(0.91); C139(0.44); C39(0.93); C80(0.88)  LDD2120  [43]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C147(1.42); C139(1.04); C80(0.09)  LDD2122  [43]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C147(0.64); C139(1.02); C39(0.84); C80(0.84)  LDD2123  [43]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C147(1.51); C139(0.94); C80(0.19)  LDD2124  [43]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C147(0.66); C139(0.86); C39(1.00); C80(0.80)  LDD2125  [43]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C147(1.56); C139(1.06); C80(0.10)  LDD2126  [43]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C147(0.89); C139(1.08); C39(1.11); C80(1.19)  LDD2127  [43]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C147(1.07); C139(0.64); C39(0.96); C80(0.98)  LDD2128  [43]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C147(0.54); C139(0.82); C39(1.33); C80(1.08)  LDD2129  [43]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C147(0.44); C139(0.42); C39(0.25); C80(0.52)  LDD2133  [43]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C147(0.44); C139(0.55); C39(0.68); C80(0.39)  LDD2134  [43]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C147(0.70); C139(0.93); C39(1.34); C80(1.35)  LDD2135  [43]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C147(0.87); C139(1.17); C39(1.47); C80(1.18)  LDD2136  [43]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C147(0.86); C139(1.07); C39(0.79); C80(0.95)  LDD2137  [43]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C39(2.21); C80(1.84); C139(1.54); C147(0.85)  LDD1700  [43]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C147(0.67); C139(1.04); C39(0.93); C80(0.75)  LDD2140  [43]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C147(0.89); C139(0.99); C39(0.71); C80(0.26)  LDD2141  [43]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C147(1.10); C139(0.56); C39(0.76); C80(0.98)  LDD2143  [43]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C147(3.39); C139(2.26); C39(2.16); C80(2.71)  LDD2144  [43]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C147(9.37); C139(7.94); C39(2.32); C80(0.79)  LDD2145  [43]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C147(0.69); C139(0.88); C39(1.01); C80(0.84)  LDD2146  [43]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C147(6.88); C139(0.92); C39(1.97); C80(3.05)  LDD2147  [43]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C147(0.40); C139(0.39); C39(0.34); C80(0.43)  LDD2148  [43]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C147(1.60); C139(1.07); C80(0.08)  LDD2149  [43]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C147(0.44); C139(0.53); C39(0.72); C80(0.54)  LDD2150  [43]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C147(2.83); C139(1.55); C39(0.84); C80(0.12)  LDD2151  [43]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C139(1.61); C39(2.49); C80(1.45)  LDD2153  [43]
 LDCM0627  NUDT7-COV-1 HEK-293T C147(0.93); C147(0.87); C139(0.76); C139(0.53)  LDD2206  [47]
 LDCM0628  OTUB2-COV-1 HEK-293T C139(0.78); C139(0.77); C139(0.75); C147(0.75)  LDD2207  [47]
 LDCM0131  RA190 MM1.R C80(1.33); C39(1.26); C139(1.19)  LDD0304  [48]
 LDCM0021  THZ1 HCT 116 C139(1.16); C39(1.23)  LDD2173  [18]
 LDCM0110  W12 Hep-G2 C139(35.45)  LDD0237  [37]
 LDCM0111  W14 Hep-G2 C139(37.25)  LDD0238  [37]
 LDCM0113  W17 Hep-G2 C139(13.91)  LDD0240  [37]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Actin, cytoplasmic 1 (ACTB) Actin family P60709
Actin, cytoplasmic 2 (ACTG1) Actin family P63261
Phospholipase D1 (PLD1) Phospholipase D family Q13393
Phospholipase D2 (PLD2) Phospholipase D family O14939
Hormonally up-regulated neu tumor-associated kinase (HUNK) CAMK Ser/Thr protein kinase family P57058
LIM domain kinase 1 (LIMK1) TKL Ser/Thr protein kinase family P53667
Epidermal growth factor receptor (EGFR) Tyr protein kinase family P00533
Protein phosphatase Slingshot homolog 1 (SSH1) Protein-tyrosine phosphatase family Q8WYL5
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein zeta/delta (YWHAZ) 14-3-3 family P63104
Optineurin (OPTN) . Q96CV9
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1 (ATXN1) ATXN1 family P54253

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Artenimol . DB11638
Copper . DB09130
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Dodecyldimethylamine N-oxide Small molecular drug DB04147

References

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2 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
3 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
4 Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos. J Am Chem Soc. 2020 Sep 30;142(39):16825-16841. doi: 10.1021/jacs.0c07726. Epub 2020 Sep 18.
Mass spectrometry data entry: PXD021557 , PXD015828
5 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
6 Proteome-Wide Profiling of Cellular Targets Modified by Dopamine Metabolites Using a Bio-Orthogonally Functionalized Catecholamine. ACS Chem Biol. 2021 Nov 19;16(11):2581-2594. doi: 10.1021/acschembio.1c00629. Epub 2021 Nov 2.
7 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
8 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
9 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
10 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
11 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
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13 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
14 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
15 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
16 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
17 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
18 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
19 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
20 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
21 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
22 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
23 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
24 Unveiling the Multifaceted Capabilities of Endophytic Aspergillus flavus Isolated from Annona squamosa Fruit Peels against Staphylococcus Isolates and HCoV 229E-In Vitro and In Silico Investigations. Pharmaceuticals (Basel). 2024 May 19;17(5):656. doi: 10.3390/ph17050656.
Mass spectrometry data entry: PXD013019
25 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
26 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
27 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
28 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
29 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
30 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
31 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
32 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
33 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
34 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
35 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
36 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
37 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
38 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
39 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
40 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
41 Crenolanib-Derived Probes Suitable for Cell- and Tissue-Based Protein Profiling and Single-Cell Imaging. Chembiochem. 2019 Jul 15;20(14):1783-1788. doi: 10.1002/cbic.201900067. Epub 2019 Jul 3.
42 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
43 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
44 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
45 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
46 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
47 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
48 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.