Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name P3  Probe Info 
Probe concentration 1 uM
Criteria Quantification: Probe vs DMSO
Quantitative Method
LFQ
In Vivo Experiment Model Model Type Living cell
Derived Tissue Skin
Disease Model Skin squamous cell carcinoma [ICD-11:2C31]
Model Name Human skin squamous cell carcinoma cells (A431)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 46 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05550  ATP-dependent RNA helicase A (DHX9) 10.0
 LDTP03159  Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) 10.0
 LDTP02911  Calpain-2 catalytic subunit (CAPN2) 10.0
 LDTP08837  Cardiomyopathy-associated protein 5 (CMYA5) 10.0
 LDTP00697  Cytochrome b5 type B (CYB5B) 10.0
 LDTP00701  D-3-phosphoglycerate dehydrogenase (PHGDH) 10.0
 LDTP05954  GDP-L-fucose synthase (GFUS) 10.0
 LDTP06294  Lysine--tRNA ligase (KARS1) 10.0
 LDTP02713  Macrophage migration inhibitory factor (MIF) 10.0
 LDTP04898  NEDD8-conjugating enzyme Ubc12 (UBE2M) 10.0
 LDTP03216  Peptidyl-prolyl cis-trans isomerase B (PPIB) 10.0
 LDTP02188  Protein disulfide-isomerase (P4HB) 10.0
 LDTP02502  Thioredoxin (TXN) 10.0
 LDTP04665  Transitional endoplasmic reticulum ATPase (VCP) 10.0
 LDTP06067  Tubulin--tyrosine ligase-like protein 12 (TTLL12) 10.0
 LDTP03166  Ubiquitin-like modifier-activating enzyme 1 (UBA1) 10.0
 LDTP12851  UDP-glucose:glycoprotein glucosyltransferase 1 (UGGT1) 10.0
 LDTP01785  Epidermal growth factor receptor (EGFR) 8.6
 LDTP02001  Catalase (CAT) 7.2
 LDTP04399  Ras-related protein Rab-7a (RAB7A) 5.2
 LDTP02162  Glucose-6-phosphate isomerase (GPI) 5.2
 LDTP03908  Malate dehydrogenase, mitochondrial (MDH2) 4.7
 LDTP02541  Heat shock cognate 71 kDa protein (HSPA8) 3.6
 LDTP05812  Ras GTPase-activating protein-binding protein 1 (G3BP1) 3.5
 LDTP03915  Eukaryotic translation initiation factor 2 subunit 3 (EIF2S3) 3.4
 LDTP12867  Very-long-chain enoyl-CoA reductase (TECR) 3.4
 LDTP12469  Nucleolar RNA helicase 2 (DDX21) 3.2
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1) 3.0
 LDTP03669  Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial (DUT) 2.5
 LDTP12922  EH domain-containing protein 3 (EHD3) 2.5
 LDTP03242  Adenosylhomocysteinase (AHCY) 2.4
 LDTP01787  Phosphoglycerate kinase 1 (PGK1) 2.1
 LDTP02672  Elongation factor 2 (EEF2) 2.1
 LDTP06192  Neutral alpha-glucosidase AB (GANAB) 2.0
 LDTP03764  Myosin-9 (MYH9) 1.9
 LDTP04878  Eukaryotic initiation factor 4A-I (EIF4A1) 1.8
 LDTP03847  Transaldolase (TALDO1) 1.8
 LDTP03521  Protein disulfide-isomerase A3 (PDIA3) 1.7
 LDTP05503  Peroxiredoxin-1 (PRDX1) 1.7
 LDTP03487  Transketolase (TKT) 1.7
 LDTP02796  Nucleoside diphosphate kinase A (NME1) 1.7
 LDTP02225  Heat shock protein HSP 90-alpha (HSP90AA1) 1.6
 LDTP02008  Fructose-bisphosphate aldolase A (ALDOA) 1.6
 LDTP02179  L-lactate dehydrogenase B chain (LDHB) 1.6
 LDTP07932  Probable ATP-dependent RNA helicase DDX46 (DDX46) 1.5
 LDTP05059  Actin, cytoplasmic 2 (ACTG1) 1.5
Transporter and channel
Click to Show/Hide to Show 21 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03385  14-3-3 protein theta (YWHAQ) 10.0
 LDTP02307  Annexin A5 (ANXA5) 10.0
 LDTP02009  Cystatin-B (CSTB) 10.0
 LDTP05292  Fatty acid-binding protein 5 (FABP5) 10.0
 LDTP00328  Importin subunit alpha-3 (KPNA4) 10.0
 LDTP04391  T-complex protein 1 subunit delta (CCT4) 10.0
 LDTP14031  Talin-1 (TLN1) 10.0
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 10.0
 LDTP02010  Annexin A1 (ANXA1) 5.4
 LDTP02199  Annexin A2 (ANXA2) 4.4
 LDTP01197  Filamin-B (FLNB) 4.3
 LDTP04885  Protein S100-A10 (S100A10) 3.3
 LDTP06350  RNA-binding protein with serine-rich domain 1 (RNPS1) 2.3
 LDTP15733  Solute carrier family 25 member 44 (SLC25A44) 2.1
 LDTP03107  Filamin-A (FLNA) 1.9
 LDTP08637  Serine/arginine repetitive matrix protein 1 (SRRM1) 1.8
 LDTP02087  ADP/ATP translocase 2 (SLC25A5) 1.8
 LDTP05252  Clathrin heavy chain 1 (CLTC) 1.8
 LDTP02959  Protein SON (SON) 1.7
 LDTP02256  Amino acid transporter heavy chain SLC3A2 (SLC3A2) 1.6
 LDTP05043  14-3-3 protein zeta/delta (YWHAZ) 1.5
Transcription factor
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP06341  Non-POU domain-containing octamer-binding protein (NONO) 5.8
Other
Click to Show/Hide to Show 95 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03618  14-3-3 protein sigma (SFN) 10.0
 LDTP02631  Alpha-actinin-1 (ACTN1) 10.0
 LDTP06121  Caprin-1 (CAPRIN1) 10.0
 LDTP03499  Elongation factor 1-delta (EEF1D) 10.0
 LDTP05421  Eukaryotic translation initiation factor 4 gamma 1 (EIF4G1) 10.0
 LDTP04743  Eukaryotic translation initiation factor 6 (EIF6) 10.0
 LDTP02435  Heat shock 70 kDa protein 1B (HSPA1B) 10.0
 LDTP04495  Heterogeneous nuclear ribonucleoprotein A3 (HNRNPA3) 10.0
 LDTP03615  Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) 10.0
 LDTP00991  Heterogeneous nuclear ribonucleoprotein Q (SYNCRIP) 10.0
 LDTP02675  Keratin, type I cytoskeletal 13 (KRT13) 10.0
 LDTP02974  Keratin, type I cytoskeletal 15 (KRT15) 10.0
 LDTP02975  Keratin, type II cytoskeletal 4 (KRT4) 10.0
 LDTP05525  KH domain-containing, RNA-binding, signal transduction-associated protein 1 (KHDRBS1) 10.0
 LDTP05974  Laminin subunit beta-3 (LAMB3) 10.0
 LDTP05021  Large ribosomal subunit protein eL30 (RPL30) 10.0
 LDTP02109  Large ribosomal subunit protein uL10 (RPLP0) 10.0
 LDTP04041  Melanoma-associated antigen 4 (MAGEA4) 10.0
 LDTP00193  PDZ and LIM domain protein 1 (PDLIM1) 10.0
 LDTP02691  Plastin-2 (LCP1) 10.0
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) 10.0
 LDTP02595  Polyadenylate-binding protein 1 (PABPC1) 10.0
 LDTP17266  Pre-mRNA-splicing factor 38B (PRPF38B) 10.0
 LDTP05484  Proteasome activator complex subunit 1 (PSME1) 10.0
 LDTP12277  Protein S100-A14 (S100A14) 10.0
 LDTP03463  Protein S100-A2 (S100A2) 10.0
 LDTP03336  Protein S100-P (S100P) 10.0
 LDTP01914  Putative HLA class I histocompatibility antigen, alpha chain H (HLA-H) 10.0
 LDTP01522  Reticulon-3 (RTN3) 10.0
 LDTP12412  Reticulon-4 (RTN4) 10.0
 LDTP03864  Small ribosomal subunit protein eS19 (RPS19) 10.0
 LDTP05014  Small ribosomal subunit protein eS26 (RPS26) 10.0
 LDTP04970  Small ribosomal subunit protein uS11 (RPS14) 10.0
 LDTP02683  Translationally-controlled tumor protein (TPT1) 10.0
 LDTP02165  Tropomyosin alpha-3 chain (TPM3) 10.0
 LDTP05076  Tubulin beta-4B chain (TUBB4B) 10.0
 LDTP01184  Tubulin-specific chaperone A (TBCA) 10.0
 LDTP17377  Tumor necrosis factor alpha-induced protein 8-like protein 2 (TNFAIP8L2) 10.0
 LDTP02990  Nucleolin (NCL) 7.2
 LDTP03899  Large ribosomal subunit protein uL13 (RPL13A) 6.6
 LDTP05424  Keratin, type I cytoskeletal 17 (KRT17) 5.8
 LDTP01932  Prelamin-A/C (LMNA) 5.8
 LDTP07954  Arginine/serine-rich coiled-coil protein 2 (RSRC2) 5.2
 LDTP00619  Eukaryotic translation initiation factor 3 subunit D (EIF3D) 4.7
 LDTP05269  Perilipin-5 (PLIN5) 4.6
 LDTP06094  Src substrate cortactin (CTTN) 4.4
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) 4.3
 LDTP03620  Protein S100-A11 (S100A11) 4.1
 LDTP02084  Plasminogen activator inhibitor 2 (SERPINB2) 4.0
 LDTP05001  Large ribosomal subunit protein uL23 (RPL23A) 4.0
 LDTP12826  Bcl-2-associated transcription factor 1 (BCLAF1) 4.0
 LDTP04027  Matrin-3 (MATR3) 3.7
 LDTP04964  Small ribosomal subunit protein eS8 (RPS8) 3.6
 LDTP02227  Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC) 3.6
 LDTP01930  Keratin, type I cytoskeletal 14 (KRT14) 3.1
 LDTP03617  14-3-3 protein beta/alpha (YWHAB) 3.1
 LDTP05509  Large ribosomal subunit protein eL18 (RPL18) 3.0
 LDTP04389  Large ribosomal subunit protein eL14 (RPL14) 2.9
 LDTP06301  Eukaryotic translation initiation factor 4H (EIF4H) 2.8
 LDTP04875  Myosin light polypeptide 6 (MYL6) 2.8
 LDTP03846  Transgelin-2 (TAGLN2) 2.8
 LDTP04919  Large ribosomal subunit protein eL15 (RPL15) 2.6
 LDTP05597  Neuroblast differentiation-associated protein AHNAK (AHNAK) 2.6
 LDTP05024  Large ribosomal subunit protein uL1 (RPL10A) 2.5
 LDTP03517  Large ribosomal subunit protein uL11 (RPL12) 2.3
 LDTP02961  Large ribosomal subunit protein uL22 (RPL17) 2.3
 LDTP02756  Junction plakoglobin (JUP) 2.3
 LDTP03364  Polypyrimidine tract-binding protein 1 (PTBP1) 2.1
 LDTP02845  Histone H1.2 (H1-2) 2.1
 LDTP04982  Small nuclear ribonucleoprotein Sm D2 (SNRPD2) 2.0
 LDTP05033  Ubiquitin-ribosomal protein eS31 fusion protein (RPS27A) 1.9
 LDTP05802  Serine/arginine-rich splicing factor 6 (SRSF6) 1.9
 LDTP02364  Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1) 1.9
 LDTP03182  Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1) 1.9
 LDTP06220  LIM and SH3 domain protein 1 (LASP1) 1.9
 LDTP04952  Heterogeneous nuclear ribonucleoprotein K (HNRNPK) 1.9
 LDTP03244  Cofilin-1 (CFL1) 1.9
 LDTP04997  Small ribosomal subunit protein eS4, X isoform (RPS4X) 1.8
 LDTP03395  Large ribosomal subunit protein uL16 (RPL10) 1.8
 LDTP04717  Small ubiquitin-related modifier 3 (SUMO3) 1.8
 LDTP04233  Large ribosomal subunit protein eL34 (RPL34) 1.8
 LDTP13919  Thyroid hormone receptor-associated protein 3 (THRAP3) 1.8
 LDTP05027  Large ribosomal subunit protein uL2 (RPL8) 1.7
 LDTP02884  Heat shock 70 kDa protein 6 (HSPA6) 1.7
 LDTP05378  Large ribosomal subunit protein eL6 (RPL6) 1.7
 LDTP04990  Large ribosomal subunit protein eL8 (RPL7A) 1.7
 LDTP05196  Large ribosomal subunit protein eL19 (RPL19) 1.7
 LDTP02779  Ezrin (EZR) 1.7
 LDTP04140  Large ribosomal subunit protein eL29 (RPL29) 1.6
 LDTP00843  Alpha-actinin-4 (ACTN4) 1.6
 LDTP13746  Serine/arginine repetitive matrix protein 2 (SRRM2) 1.6
 LDTP03367  Elongation factor 1-gamma (EEF1G) 1.5
 LDTP06598  Fascin (FSCN1) 1.5
 LDTP04684  Nucleosome assembly protein 1-like 1 (NAP1L1) 1.5
 LDTP03815  Large ribosomal subunit protein uL4 (RPL4) 1.5

References

1 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.