Details of the Target

General Information of Target

Target ID LDTP02162
Target Name Glucose-6-phosphate isomerase (GPI)
Gene Name GPI
Gene ID 2821
Synonyms
Glucose-6-phosphate isomerase; GPI; EC 5.3.1.9; Autocrine motility factor; AMF; Neuroleukin; NLK; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI; Sperm antigen 36; SA-36
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAALTRDPQFQKLQQWYREHRSELNLRRLFDANKDRFNHFSLTLNTNHGHILVDYSKNLV
TEDVMRMLVDLAKSRGVEAARERMFNGEKINYTEGRAVLHVALRNRSNTPILVDGKDVMP
EVNKVLDKMKSFCQRVRSGDWKGYTGKTITDVINIGIGGSDLGPLMVTEALKPYSSGGPR
VWYVSNIDGTHIAKTLAQLNPESSLFIIASKTFTTQETITNAETAKEWFLQAAKDPSAVA
KHFVALSTNTTKVKEFGIDPQNMFEFWDWVGGRYSLWSAIGLSIALHVGFDNFEQLLSGA
HWMDQHFRTTPLEKNAPVLLALLGIWYINCFGCETHAMLPYDQYLHRFAAYFQQGDMESN
GKYITKSGTRVDHQTGPIVWGEPGTNGQHAFYQLIHQGTKMIPCDFLIPVQTQHPIRKGL
HHKILLANFLAQTEALMRGKSTEEARKELQAAGKSPEDLERLLPHKVFEGNRPTNSIVFT
KLTPFMLGALVAMYEHKIFVQGIIWDINSFDQWGVELGKQLAKKIEPELDGSAQVTSHDA
STNGLINFIKQQREARVQ
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
GPI family
Subcellular location
Cytoplasm
Function
In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis. Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility. Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons. It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion.
TTD ID
T54316
Uniprot ID
P06744
DrugMap ID
TT19JIZ
Ensemble ID
ENST00000356487.11
HGNC ID
HGNC:4458
ChEMBL ID
CHEMBL4295702

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CALU6 SNV: p.K116N DBIA    Probe Info 
HCT116 SNV: p.A279D .
REH SNV: p.R83Q DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 48 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
P2
 Probe Info  		10.00  LDD0449  [1]
P3
 Probe Info  		5.18  LDD0450  [1]
P8
 Probe Info  		2.90  LDD0451  [1]
A-EBA
 Probe Info  		3.01  LDD0215  [2]
CY4
 Probe Info  		100.00  LDD0244  [3]
N1
 Probe Info  		100.00  LDD0242  [3]
C-Sul
 Probe Info  		4.87  LDD0066  [4]
TH211
 Probe Info  		Y392(12.96); Y92(12.51); Y351(6.35)  LDD0257  [5]
TH214
 Probe Info  		Y392(20.00); Y144(19.09); Y351(17.61)  LDD0258  [5]
TH216
 Probe Info  		Y351(20.00); Y92(20.00); Y144(6.20)  LDD0259  [5]
YN-1
 Probe Info  		100.00  LDD0444  [6]
YN-4
 Probe Info  		100.00  LDD0445  [6]
AZ-9
 Probe Info  		D63(0.93); E62(0.90); E457(0.73); E223(0.91)  LDD2208  [7]
ONAyne
 Probe Info  		K524(0.00); K447(0.00); K454(0.00); K440(0.00)  LDD0273  [8]
OPA-S-S-alkyne
 Probe Info  		K12(0.87); K89(1.12); K440(1.78); K34(2.53)  LDD3494  [9]
Probe 1
 Probe Info  		Y17(20.40); Y92(282.70); Y351(13.00)  LDD3495  [10]
DBIA
 Probe Info  		C415(1.07)  LDD3310  [11]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [12]
THZ1-DTB
 Probe Info  		C404(1.05)  LDD0460  [12]
BTD
 Probe Info  		C404(1.23)  LDD2089  [13]
AHL-Pu-1
 Probe Info  		C404(20.00)  LDD0168  [14]
HHS-482
 Probe Info  		Y144(0.34); Y183(1.35); Y351(0.95)  LDD0285  [15]
HHS-475
 Probe Info  		Y144(0.61); Y92(0.94)  LDD0264  [16]
HHS-465
 Probe Info  		Y183(1.40); Y92(10.00)  LDD2237  [17]
5E-2FA
 Probe Info  		N.A.  LDD2235  [18]
ATP probe
 Probe Info  		K454(0.00); K447(0.00); K12(0.00); K252(0.00)  LDD0199  [19]
m-APA
 Probe Info  		N.A.  LDD2231  [18]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [20]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [21]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [22]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [22]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [20]
ATP probe
 Probe Info  		K252(0.00); K172(0.00); K524(0.00)  LDD0035  [23]
IPM
 Probe Info  		N.A.  LDD0025  [24]
WYneN
 Probe Info  		N.A.  LDD0021  [25]
Compound 10
 Probe Info  		N.A.  LDD2216  [26]
Compound 11
 Probe Info  		N.A.  LDD2213  [26]
NHS
 Probe Info  		K524(0.00); K12(0.00); K241(0.00); K116(0.00)  LDD0010  [25]
SF
 Probe Info  		K454(0.00); K366(0.00); Y92(0.00)  LDD0028  [27]
STPyne
 Probe Info  		K116(0.00); K524(0.00); K454(0.00)  LDD0009  [25]
TFBX
 Probe Info  		N.A.  LDD0148  [24]
Ox-W18
 Probe Info  		W228(0.00); W380(0.00)  LDD2175  [28]
1c-yne
 Probe Info  		K454(0.00); K362(0.00); K241(0.00); K234(0.00)  LDD0228  [29]
1d-yne
 Probe Info  		K447(0.00); K524(0.00)  LDD0357  [29]
Acrolein
 Probe Info  		H242(0.00); H50(0.00); C404(0.00); H48(0.00)  LDD0217  [30]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [30]
Methacrolein
 Probe Info  		H242(0.00); H191(0.00); C404(0.00)  LDD0218  [30]
NAIA_5
 Probe Info  		C404(0.00); C133(0.00); C330(0.00); C333(0.00)  LDD2223  [31]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C278
 Probe Info  		73.01  LDD1948  [32]
VE-P
 Probe Info  		N.A.  LDD0396  [33]
STS-1
 Probe Info  		N.A.  LDD0068  [34]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C404(0.61)  LDD2142  [13]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C404(0.86)  LDD2112  [13]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C404(0.56)  LDD2095  [13]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C404(0.92)  LDD2130  [13]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C404(1.78)  LDD2117  [13]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C404(1.10)  LDD2103  [13]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C404(0.41)  LDD2132  [13]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C404(1.03)  LDD2131  [13]
 LDCM0025  4SU-RNA HEK-293T C404(20.00)  LDD0168  [14]
 LDCM0026  4SU-RNA+native RNA HEK-293T C404(12.49)  LDD0169  [14]
 LDCM0214  AC1 HEK-293T C404(1.08)  LDD1507  [35]
 LDCM0215  AC10 HEK-293T C404(1.03)  LDD1508  [35]
 LDCM0226  AC11 HEK-293T C404(0.95)  LDD1509  [35]
 LDCM0237  AC12 HEK-293T C404(0.99)  LDD1510  [35]
 LDCM0259  AC14 HEK-293T C404(0.84)  LDD1512  [35]
 LDCM0270  AC15 HEK-293T C404(0.96)  LDD1513  [35]
 LDCM0276  AC17 HEK-293T C404(0.92)  LDD1515  [35]
 LDCM0277  AC18 HEK-293T C404(1.10)  LDD1516  [35]
 LDCM0278  AC19 HEK-293T C404(0.88)  LDD1517  [35]
 LDCM0279  AC2 HEK-293T C404(1.18)  LDD1518  [35]
 LDCM0280  AC20 HEK-293T C404(0.99)  LDD1519  [35]
 LDCM0281  AC21 HEK-293T C404(0.98)  LDD1520  [35]
 LDCM0282  AC22 HEK-293T C404(0.92)  LDD1521  [35]
 LDCM0283  AC23 HEK-293T C404(0.98)  LDD1522  [35]
 LDCM0284  AC24 HEK-293T C404(0.85)  LDD1523  [35]
 LDCM0285  AC25 HEK-293T C404(1.07)  LDD1524  [35]
 LDCM0286  AC26 HEK-293T C404(1.02)  LDD1525  [35]
 LDCM0287  AC27 HEK-293T C404(0.98)  LDD1526  [35]
 LDCM0288  AC28 HEK-293T C404(1.05)  LDD1527  [35]
 LDCM0289  AC29 HEK-293T C404(0.92)  LDD1528  [35]
 LDCM0290  AC3 HEK-293T C404(1.06)  LDD1529  [35]
 LDCM0291  AC30 HEK-293T C404(0.96)  LDD1530  [35]
 LDCM0292  AC31 HEK-293T C404(0.92)  LDD1531  [35]
 LDCM0293  AC32 HEK-293T C404(0.99)  LDD1532  [35]
 LDCM0294  AC33 HEK-293T C404(1.06)  LDD1533  [35]
 LDCM0295  AC34 HEK-293T C404(1.00)  LDD1534  [35]
 LDCM0296  AC35 HEK-293T C404(0.96)  LDD1535  [35]
 LDCM0297  AC36 HEK-293T C404(1.05)  LDD1536  [35]
 LDCM0298  AC37 HEK-293T C404(1.00)  LDD1537  [35]
 LDCM0299  AC38 HEK-293T C404(0.93)  LDD1538  [35]
 LDCM0300  AC39 HEK-293T C404(0.97)  LDD1539  [35]
 LDCM0301  AC4 HEK-293T C404(1.09)  LDD1540  [35]
 LDCM0302  AC40 HEK-293T C404(0.91)  LDD1541  [35]
 LDCM0303  AC41 HEK-293T C404(0.99)  LDD1542  [35]
 LDCM0304  AC42 HEK-293T C404(1.00)  LDD1543  [35]
 LDCM0305  AC43 HEK-293T C404(0.93)  LDD1544  [35]
 LDCM0306  AC44 HEK-293T C404(1.00)  LDD1545  [35]
 LDCM0307  AC45 HEK-293T C404(0.98)  LDD1546  [35]
 LDCM0308  AC46 HEK-293T C404(0.94)  LDD1547  [35]
 LDCM0309  AC47 HEK-293T C404(0.87)  LDD1548  [35]
 LDCM0310  AC48 HEK-293T C404(0.98)  LDD1549  [35]
 LDCM0311  AC49 HEK-293T C404(0.96)  LDD1550  [35]
 LDCM0312  AC5 HEK-293T C404(1.02)  LDD1551  [35]
 LDCM0313  AC50 HEK-293T C404(1.05)  LDD1552  [35]
 LDCM0314  AC51 HEK-293T C404(0.95)  LDD1553  [35]
 LDCM0315  AC52 HEK-293T C404(0.99)  LDD1554  [35]
 LDCM0316  AC53 HEK-293T C404(1.02)  LDD1555  [35]
 LDCM0317  AC54 HEK-293T C404(0.88)  LDD1556  [35]
 LDCM0318  AC55 HEK-293T C404(0.95)  LDD1557  [35]
 LDCM0319  AC56 HEK-293T C404(0.89)  LDD1558  [35]
 LDCM0320  AC57 HEK-293T C404(1.05)  LDD1559  [35]
 LDCM0321  AC58 HEK-293T C404(1.07)  LDD1560  [35]
 LDCM0322  AC59 HEK-293T C404(1.04)  LDD1561  [35]
 LDCM0323  AC6 HEK-293T C404(0.99)  LDD1562  [35]
 LDCM0324  AC60 HEK-293T C404(1.11)  LDD1563  [35]
 LDCM0325  AC61 HEK-293T C404(1.06)  LDD1564  [35]
 LDCM0326  AC62 HEK-293T C404(0.99)  LDD1565  [35]
 LDCM0327  AC63 HEK-293T C404(1.01)  LDD1566  [35]
 LDCM0328  AC64 HEK-293T C404(1.07)  LDD1567  [35]
 LDCM0334  AC7 HEK-293T C404(0.97)  LDD1568  [35]
 LDCM0345  AC8 HEK-293T C404(1.08)  LDD1569  [35]
 LDCM0248  AKOS034007472 HEK-293T C404(0.96)  LDD1511  [35]
 LDCM0356  AKOS034007680 HEK-293T C404(0.93)  LDD1570  [35]
 LDCM0275  AKOS034007705 HEK-293T C404(0.90)  LDD1514  [35]
 LDCM0498  BS-3668 MDA-MB-231 C404(0.98)  LDD2091  [13]
 LDCM0108  Chloroacetamide HeLa H50(0.00); C404(0.00); H48(0.00); H242(0.00)  LDD0222  [30]
 LDCM0367  CL1 HEK-293T C404(0.92)  LDD1571  [35]
 LDCM0368  CL10 HEK-293T C404(0.74)  LDD1572  [35]
 LDCM0369  CL100 HEK-293T C404(1.09)  LDD1573  [35]
 LDCM0370  CL101 HEK-293T C404(1.00)  LDD1574  [35]
 LDCM0371  CL102 HEK-293T C404(0.93)  LDD1575  [35]
 LDCM0372  CL103 HEK-293T C404(0.84)  LDD1576  [35]
 LDCM0373  CL104 HEK-293T C404(1.05)  LDD1577  [35]
 LDCM0374  CL105 HEK-293T C404(0.97)  LDD1578  [35]
 LDCM0375  CL106 HEK-293T C404(0.99)  LDD1579  [35]
 LDCM0376  CL107 HEK-293T C404(0.87)  LDD1580  [35]
 LDCM0377  CL108 HEK-293T C404(1.01)  LDD1581  [35]
 LDCM0378  CL109 HEK-293T C404(0.98)  LDD1582  [35]
 LDCM0379  CL11 HEK-293T C404(0.92)  LDD1583  [35]
 LDCM0380  CL110 HEK-293T C404(0.98)  LDD1584  [35]
 LDCM0381  CL111 HEK-293T C404(0.91)  LDD1585  [35]
 LDCM0382  CL112 HEK-293T C404(0.99)  LDD1586  [35]
 LDCM0383  CL113 HEK-293T C404(0.92)  LDD1587  [35]
 LDCM0384  CL114 HEK-293T C404(0.99)  LDD1588  [35]
 LDCM0385  CL115 HEK-293T C404(0.95)  LDD1589  [35]
 LDCM0386  CL116 HEK-293T C404(1.03)  LDD1590  [35]
 LDCM0387  CL117 HEK-293T C404(1.01)  LDD1591  [35]
 LDCM0388  CL118 HEK-293T C404(0.99)  LDD1592  [35]
 LDCM0389  CL119 HEK-293T C404(0.92)  LDD1593  [35]
 LDCM0390  CL12 HEK-293T C404(0.59)  LDD1594  [35]
 LDCM0391  CL120 HEK-293T C404(0.99)  LDD1595  [35]
 LDCM0392  CL121 HEK-293T C404(0.95)  LDD1596  [35]
 LDCM0393  CL122 HEK-293T C404(0.95)  LDD1597  [35]
 LDCM0394  CL123 HEK-293T C404(1.02)  LDD1598  [35]
 LDCM0395  CL124 HEK-293T C404(1.00)  LDD1599  [35]
 LDCM0396  CL125 HEK-293T C404(0.92)  LDD1600  [35]
 LDCM0397  CL126 HEK-293T C404(0.98)  LDD1601  [35]
 LDCM0398  CL127 HEK-293T C404(1.11)  LDD1602  [35]
 LDCM0399  CL128 HEK-293T C404(1.16)  LDD1603  [35]
 LDCM0400  CL13 HEK-293T C404(0.90)  LDD1604  [35]
 LDCM0401  CL14 HEK-293T C404(0.92)  LDD1605  [35]
 LDCM0402  CL15 HEK-293T C404(0.83)  LDD1606  [35]
 LDCM0403  CL16 HEK-293T C404(0.81)  LDD1607  [35]
 LDCM0404  CL17 HEK-293T C404(0.94)  LDD1608  [35]
 LDCM0405  CL18 HEK-293T C404(0.77)  LDD1609  [35]
 LDCM0406  CL19 HEK-293T C404(0.67)  LDD1610  [35]
 LDCM0407  CL2 HEK-293T C404(1.02)  LDD1611  [35]
 LDCM0408  CL20 HEK-293T C404(0.74)  LDD1612  [35]
 LDCM0409  CL21 HEK-293T C404(0.59)  LDD1613  [35]
 LDCM0410  CL22 HEK-293T C404(0.71)  LDD1614  [35]
 LDCM0411  CL23 HEK-293T C404(0.87)  LDD1615  [35]
 LDCM0412  CL24 HEK-293T C404(0.60)  LDD1616  [35]
 LDCM0413  CL25 HEK-293T C404(0.97)  LDD1617  [35]
 LDCM0414  CL26 HEK-293T C404(0.92)  LDD1618  [35]
 LDCM0415  CL27 HEK-293T C404(0.91)  LDD1619  [35]
 LDCM0416  CL28 HEK-293T C404(0.89)  LDD1620  [35]
 LDCM0417  CL29 HEK-293T C404(0.93)  LDD1621  [35]
 LDCM0418  CL3 HEK-293T C404(0.91)  LDD1622  [35]
 LDCM0419  CL30 HEK-293T C404(0.81)  LDD1623  [35]
 LDCM0420  CL31 HEK-293T C404(0.67)  LDD1624  [35]
 LDCM0421  CL32 HEK-293T C404(0.81)  LDD1625  [35]
 LDCM0422  CL33 HEK-293T C404(0.69)  LDD1626  [35]
 LDCM0423  CL34 HEK-293T C404(0.74)  LDD1627  [35]
 LDCM0424  CL35 HEK-293T C404(0.84)  LDD1628  [35]
 LDCM0425  CL36 HEK-293T C404(0.58)  LDD1629  [35]
 LDCM0426  CL37 HEK-293T C404(0.99)  LDD1630  [35]
 LDCM0428  CL39 HEK-293T C404(0.92)  LDD1632  [35]
 LDCM0429  CL4 HEK-293T C404(1.03)  LDD1633  [35]
 LDCM0430  CL40 HEK-293T C404(0.93)  LDD1634  [35]
 LDCM0431  CL41 HEK-293T C404(1.07)  LDD1635  [35]
 LDCM0432  CL42 HEK-293T C404(0.96)  LDD1636  [35]
 LDCM0433  CL43 HEK-293T C404(0.67)  LDD1637  [35]
 LDCM0434  CL44 HEK-293T C404(0.86)  LDD1638  [35]
 LDCM0435  CL45 HEK-293T C404(0.67)  LDD1639  [35]
 LDCM0436  CL46 HEK-293T C404(0.79)  LDD1640  [35]
 LDCM0437  CL47 HEK-293T C404(0.90)  LDD1641  [35]
 LDCM0438  CL48 HEK-293T C404(0.65)  LDD1642  [35]
 LDCM0439  CL49 HEK-293T C404(0.87)  LDD1643  [35]
 LDCM0440  CL5 HEK-293T C404(1.08)  LDD1644  [35]
 LDCM0441  CL50 HEK-293T C404(0.90)  LDD1645  [35]
 LDCM0443  CL52 HEK-293T C404(0.91)  LDD1646  [35]
 LDCM0444  CL53 HEK-293T C404(0.99)  LDD1647  [35]
 LDCM0445  CL54 HEK-293T C404(0.91)  LDD1648  [35]
 LDCM0446  CL55 HEK-293T C404(0.65)  LDD1649  [35]
 LDCM0447  CL56 HEK-293T C404(0.80)  LDD1650  [35]
 LDCM0448  CL57 HEK-293T C404(0.65)  LDD1651  [35]
 LDCM0449  CL58 HEK-293T C404(0.77)  LDD1652  [35]
 LDCM0450  CL59 HEK-293T C404(0.92)  LDD1653  [35]
 LDCM0451  CL6 HEK-293T C404(0.96)  LDD1654  [35]
 LDCM0452  CL60 HEK-293T C404(0.60)  LDD1655  [35]
 LDCM0453  CL61 HEK-293T C404(0.94)  LDD1656  [35]
 LDCM0454  CL62 HEK-293T C404(1.00)  LDD1657  [35]
 LDCM0455  CL63 HEK-293T C404(0.97)  LDD1658  [35]
 LDCM0456  CL64 HEK-293T C404(0.94)  LDD1659  [35]
 LDCM0457  CL65 HEK-293T C404(0.98)  LDD1660  [35]
 LDCM0458  CL66 HEK-293T C404(0.92)  LDD1661  [35]
 LDCM0459  CL67 HEK-293T C404(0.77)  LDD1662  [35]
 LDCM0460  CL68 HEK-293T C404(0.86)  LDD1663  [35]
 LDCM0461  CL69 HEK-293T C404(0.75)  LDD1664  [35]
 LDCM0462  CL7 HEK-293T C404(0.79)  LDD1665  [35]
 LDCM0463  CL70 HEK-293T C404(0.73)  LDD1666  [35]
 LDCM0464  CL71 HEK-293T C404(0.88)  LDD1667  [35]
 LDCM0465  CL72 HEK-293T C404(0.64)  LDD1668  [35]
 LDCM0466  CL73 HEK-293T C404(0.93)  LDD1669  [35]
 LDCM0467  CL74 HEK-293T C404(1.04)  LDD1670  [35]
 LDCM0469  CL76 HEK-293T C404(1.06)  LDD1672  [35]
 LDCM0470  CL77 HEK-293T C404(0.94)  LDD1673  [35]
 LDCM0471  CL78 HEK-293T C404(0.95)  LDD1674  [35]
 LDCM0472  CL79 HEK-293T C404(0.82)  LDD1675  [35]
 LDCM0473  CL8 HEK-293T C404(0.80)  LDD1676  [35]
 LDCM0474  CL80 HEK-293T C404(0.93)  LDD1677  [35]
 LDCM0475  CL81 HEK-293T C404(0.75)  LDD1678  [35]
 LDCM0476  CL82 HEK-293T C404(0.82)  LDD1679  [35]
 LDCM0477  CL83 HEK-293T C404(1.01)  LDD1680  [35]
 LDCM0478  CL84 HEK-293T C404(0.73)  LDD1681  [35]
 LDCM0479  CL85 HEK-293T C404(0.94)  LDD1682  [35]
 LDCM0480  CL86 HEK-293T C404(1.03)  LDD1683  [35]
 LDCM0481  CL87 HEK-293T C404(1.21)  LDD1684  [35]
 LDCM0482  CL88 HEK-293T C404(1.33)  LDD1685  [35]
 LDCM0483  CL89 HEK-293T C404(1.09)  LDD1686  [35]
 LDCM0484  CL9 HEK-293T C404(0.75)  LDD1687  [35]
 LDCM0485  CL90 HEK-293T C404(1.14)  LDD1688  [35]
 LDCM0486  CL91 HEK-293T C404(1.01)  LDD1689  [35]
 LDCM0487  CL92 HEK-293T C404(0.97)  LDD1690  [35]
 LDCM0488  CL93 HEK-293T C404(0.80)  LDD1691  [35]
 LDCM0489  CL94 HEK-293T C404(0.84)  LDD1692  [35]
 LDCM0490  CL95 HEK-293T C404(1.07)  LDD1693  [35]
 LDCM0491  CL96 HEK-293T C404(1.02)  LDD1694  [35]
 LDCM0492  CL97 HEK-293T C404(0.93)  LDD1695  [35]
 LDCM0493  CL98 HEK-293T C404(0.92)  LDD1696  [35]
 LDCM0494  CL99 HEK-293T C404(1.02)  LDD1697  [35]
 LDCM0495  E2913 HEK-293T C404(0.88)  LDD1698  [35]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C404(1.38)  LDD1702  [13]
 LDCM0625  F8 Ramos C404(0.49)  LDD2187  [36]
 LDCM0572  Fragment10 Ramos C404(0.58)  LDD2189  [36]
 LDCM0573  Fragment11 Ramos C404(0.06)  LDD2190  [36]
 LDCM0574  Fragment12 Ramos C404(0.56)  LDD2191  [36]
 LDCM0575  Fragment13 Ramos C404(1.55)  LDD2192  [36]
 LDCM0576  Fragment14 Ramos C404(0.84)  LDD2193  [36]
 LDCM0579  Fragment20 Ramos C404(0.50)  LDD2194  [36]
 LDCM0580  Fragment21 Ramos C404(0.75)  LDD2195  [36]
 LDCM0582  Fragment23 Ramos C404(1.58)  LDD2196  [36]
 LDCM0578  Fragment27 Ramos C404(1.14)  LDD2197  [36]
 LDCM0586  Fragment28 Ramos C404(1.23)  LDD2198  [36]
 LDCM0588  Fragment30 Ramos C404(1.08)  LDD2199  [36]
 LDCM0589  Fragment31 Ramos C404(1.16)  LDD2200  [36]
 LDCM0590  Fragment32 Ramos C404(0.50)  LDD2201  [36]
 LDCM0468  Fragment33 HEK-293T C404(1.07)  LDD1671  [35]
 LDCM0596  Fragment38 Ramos C404(1.60)  LDD2203  [36]
 LDCM0566  Fragment4 Ramos C404(0.69)  LDD2184  [36]
 LDCM0427  Fragment51 HEK-293T C404(0.90)  LDD1631  [35]
 LDCM0610  Fragment52 Ramos C404(1.61)  LDD2204  [36]
 LDCM0614  Fragment56 Ramos C404(0.95)  LDD2205  [36]
 LDCM0569  Fragment7 Ramos C404(0.46)  LDD2186  [36]
 LDCM0571  Fragment9 Ramos C404(0.39)  LDD2188  [36]
 LDCM0116  HHS-0101 DM93 Y144(0.61); Y92(0.94)  LDD0264  [16]
 LDCM0117  HHS-0201 DM93 Y92(0.86); Y144(1.57)  LDD0265  [16]
 LDCM0118  HHS-0301 DM93 Y144(0.60); Y92(0.94)  LDD0266  [16]
 LDCM0119  HHS-0401 DM93 Y144(0.63); Y92(0.95)  LDD0267  [16]
 LDCM0120  HHS-0701 DM93 Y92(0.91); Y144(0.91)  LDD0268  [16]
 LDCM0107  IAA HeLa H50(0.00); H48(0.00); C404(0.00); H100(0.00)  LDD0221  [30]
 LDCM0123  JWB131 DM93 Y144(0.34); Y183(1.35); Y351(0.95)  LDD0285  [15]
 LDCM0124  JWB142 DM93 Y144(0.58); Y183(0.44); Y351(1.69)  LDD0286  [15]
 LDCM0125  JWB146 DM93 Y144(0.42); Y183(1.11); Y351(0.65)  LDD0287  [15]
 LDCM0126  JWB150 DM93 Y144(0.43); Y183(7.15)  LDD0288  [15]
 LDCM0127  JWB152 DM93 Y144(1.40); Y183(4.07); Y351(1.96)  LDD0289  [15]
 LDCM0128  JWB198 DM93 Y144(0.10); Y183(1.27); Y351(0.12)  LDD0290  [15]
 LDCM0129  JWB202 DM93 Y144(0.31); Y183(0.59); Y351(1.07)  LDD0291  [15]
 LDCM0130  JWB211 DM93 Y144(0.21); Y183(0.89); Y351(0.49)  LDD0292  [15]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [12]
 LDCM0022  KB02 HEK-293T C404(1.09)  LDD1492  [35]
 LDCM0023  KB03 HEK-293T C404(0.97)  LDD1497  [35]
 LDCM0024  KB05 COLO792 C415(1.07)  LDD3310  [11]
 LDCM0109  NEM HeLa H50(0.00); H48(0.00); C404(0.00); H242(0.00)  LDD0223  [30]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C404(1.23)  LDD2089  [13]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C404(1.13)  LDD2092  [13]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C404(1.75)  LDD2094  [13]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C404(0.97)  LDD2098  [13]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C404(1.22)  LDD2099  [13]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C404(0.52)  LDD2100  [13]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C404(1.11)  LDD2105  [13]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C404(0.61)  LDD2106  [13]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C404(0.92)  LDD2107  [13]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C404(0.90)  LDD2109  [13]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C404(0.79)  LDD2110  [13]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C404(0.78)  LDD2114  [13]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C404(0.96)  LDD2120  [13]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C404(1.00)  LDD2123  [13]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C404(1.10)  LDD2125  [13]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C404(1.02)  LDD2127  [13]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C404(1.02)  LDD2128  [13]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C404(0.70)  LDD2134  [13]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C404(1.30)  LDD2136  [13]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C404(1.06)  LDD2137  [13]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C404(0.91)  LDD2141  [13]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C404(0.84)  LDD2143  [13]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C404(0.27)  LDD2145  [13]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C404(0.96)  LDD2146  [13]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C404(0.82)  LDD2147  [13]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C404(0.47)  LDD2148  [13]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C404(0.94)  LDD2150  [13]
 LDCM0021  THZ1 HeLa S3 C404(1.05)  LDD0460  [12]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Phosphatidate cytidylyltransferase, mitochondrial (TAMM41) TAM41 family Q96BW9

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Artenimol . DB11638
Copper . DB09130
Investigative
Click To Hide/Show 8 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
6-phospho-d-gluconic Acid Small molecular drug DB02076
Alpha-d-glucose 6-phosphate Small molecular drug DB02007
D-erythrose 4-phosphate Small molecular drug DB03937
Fructose-6-phosphate Small molecular drug DB04493
Glucose-6-phosphate Small molecular drug DB03581
5-phospho-d-arabinohydroxamic Acid . DB02093
5-phosphoarabinonic Acid . DB03042
D-glucitol 6-phosphate . DB02548

References

1 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
7 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
8 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
9 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
10 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
11 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
12 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
13 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
14 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
15 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
16 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
17 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
18 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
19 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
20 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
21 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
22 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
23 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
24 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
25 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
26 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
27 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
28 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
29 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
30 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
31 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
32 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
33 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
34 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
35 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
36 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578