Details of the Probe

General Information of Probe

Probe ID
LDPC0254
Probe Name
JZ128-DTB
Probe Type
ABPP Probe
Structure
2D MOL
Ro5 Violations (Lipinski): 5 Molecular Weight (mw) 988.204
Lipid-water partition coefficient (xlogp) 6.43852
Rotatable Bond Count (rotbonds) 31
Hydrogen Bond Donor Count (hbonddonor) 8
Hydrogen Bond Acceptor Count (hbondacc) 12
Chemical Identifiers
Formula
C53H69N11O8
Canonical SMILES
Cc1cccc2[nH]cc(-c3ccnc(Nc4cccc(NC(=O)c5ccc(NC(=O)C=CCN(C)CCCC(=O)NCCOCCOCCOCCNC(=O)CCCCCC6NC(=O)NC6C)cc5)c4)n3)c12
InChI
InChI=1S/C53H69N11O8/c1-37-11-7-15-46-50(37)43(36-57-46)45-23-24-56-52(62-45)61-42-13-8-12-41(35-42)60-51(68)39-19-21-40(22-20-39)59-49(67)18-10-28-64(3)27-9-17-48(66)55-26-30-71-32-34-72-33-31-70-29-25-54-47(65)16-6-4-5-14-44-38(2)58-53(69)63-44/h7-8,10-13,15,18-24,35-36,38,44,57H,4-6,9,14,16-17,25-34H2,1-3H3,(H,54,65)(H,55,66)(H,59,67)(H,60,68)(H,56,61,62)(H2,58,63,69)/b18-10+/t38-,44+/m1/s1
InChIKey
SUOYIWUEZJOKES-OKNOHJAESA-N

The Probe Interaction Atlas

Target(s) List of this Probe

185 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 (ABHD5) LDTP09542 C299  LDD0462 
1-phosphatidylinositol 3-phosphate 5-kinase (PIKFYVE) LDTP13873 C1970  LDD0462 
2-hydroxyacyl-CoA lyase 2 (ILVBL) LDTP00032 C315; C568  LDD0462 
26S proteasome regulatory subunit 10B (PSMC6) LDTP04987 C170; C193  LDD0462 
5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1) LDTP05761 C185  LDD0462 
6-phosphogluconate dehydrogenase, decarboxylating (PGD) LDTP04499 C171  LDD0462 
6-phosphogluconolactonase (PGLS) LDTP14535 C32  LDD0462 
60 kDa heat shock protein, mitochondrial (HSPD1) LDTP02522 C237; C447; C442  LDD0462 
7-dehydrocholesterol reductase (DHCR7) LDTP13131 C380  LDD0462 
Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) LDTP03291 C119  LDD0462 
Actin, alpha skeletal muscle (ACTA1) LDTP05073 C219  LDD0462 
Actin, cytoplasmic 1 (ACTB) LDTP04876 C257; C217  LDD0462 
Acyl-coenzyme A diphosphatase FITM2 (FITM2) LDTP08943 C251  LDD0462 
Adenosine kinase (ADK) LDTP04689 C140  LDD0462 
ADP-ribosylation factor 1 (ARF1) LDTP05192 C159  LDD0462 
ADP-ribosylation factor 4 (ARF4) LDTP02942 C159  LDD0462 
ADP-ribosylation factor-related protein 1 (ARFRP1) LDTP05982 C125; C141  LDD0462 
Alcohol dehydrogenase class-3 (ADH5) LDTP02587 C97  LDD0462 
All-trans-retinol 13,14-reductase (RETSAT) LDTP15097 C534  LDD0462 
Alpha-aminoadipic semialdehyde dehydrogenase (ALDH7A1) LDTP04253 C478; C70  LDD0462 
Alpha-enolase (ENO1) LDTP02159 C337; C119; C389  LDD0462 
Antigen peptide transporter 2 (TAP2) LDTP05409 C353  LDD0462 
Arginine--tRNA ligase, cytoplasmic (RARS1) LDTP04601 C502  LDD0462 
Asparagine--tRNA ligase, cytoplasmic (NARS1) LDTP00866 C202  LDD0462 
Atlastin-3 (ATL3) LDTP07362 C371  LDD0462 
ATP-dependent 6-phosphofructokinase, liver type (PFKL) LDTP02925 C708  LDD0462 
ATP-dependent RNA helicase A (DHX9) LDTP05550 C612  LDD0462 
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) LDTP03159 C288; C63  LDD0462 
Calpain-1 catalytic subunit (CAPN1) LDTP02204 C108  LDD0462 
Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A) LDTP04358 C96; C304  LDD0462 
Cathepsin B (CTSB) LDTP02223 C319  LDD0462 
Cell division control protein 42 homolog (CDC42) LDTP04886 C157  LDD0462 
Citrate synthase, mitochondrial (CS) LDTP01205 C211  LDD0462 
Cullin-associated NEDD8-dissociated protein 1 (CAND1) LDTP08296 C237  LDD0462 
Cyclin-dependent kinase 12 (CDK12) LDTP12852 C1039  LDD0462 
Cytidine deaminase (CDA) LDTP03642 C53  LDD0462 
Cytochrome b-c1 complex subunit 1, mitochondrial (UQCRC1) LDTP03610 C453; C410  LDD0462 
Cytochrome c oxidase subunit 1 (MT-CO1) LDTP01772 C498  LDD0462 
Cytochrome c oxidase subunit NDUFA4 (NDUFA4) LDTP00293 C44  LDD0462 
Cytochrome P450 1B1 (CYP1B1) LDTP06608 C92  LDD0462 
D-3-phosphoglycerate dehydrogenase (PHGDH) LDTP00701 C281; C421; C369  LDD0462 
DCN1-like protein 5 (DCUN1D5) LDTP11199 C115  LDD0462 
Dehydrogenase/reductase SDR family member 7 (DHRS7) LDTP13959 C233; C204  LDD0462 
Dihydroxyacetone phosphate acyltransferase (GNPAT) LDTP00577 C54  LDD0462 
Dipeptidyl peptidase 1 (CTSC) LDTP04572 C321  LDD0462 
DNA dC->dU-editing enzyme APOBEC-3C (APOBEC3C) LDTP12539 C65  LDD0462 
DNA repair nuclease/redox regulator APEX1 (APEX1) LDTP03398 C208  LDD0462 
DNA-dependent protein kinase catalytic subunit (PRKDC) LDTP05136 C232; C4061; C974; C223  LDD0462 
Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) LDTP13087 C67  LDD0462 
Dolichyl-phosphate beta-glucosyltransferase (ALG5) LDTP14214 C194  LDD0462 
Dual specificity mitogen-activated protein kinase kinase 7 (MAP2K7) LDTP00414 C131  LDD0462 
Dynamin-1-like protein (DNM1L) LDTP00273 C361  LDD0462 
Dynamin-like 120 kDa protein, mitochondrial (OPA1) LDTP00950 C786  LDD0462 
E3 ubiquitin-protein ligase RNF149 (RNF149) LDTP09079 C269  LDD0462 
Elongation factor 1-alpha 1 (EEF1A1) LDTP05071 C411; C363; C370; C234  LDD0462 
Elongation factor 2 (EEF2) LDTP02672 C591; C751; C41; C728  LDD0462 
Elongation factor Tu, mitochondrial (TUFM) LDTP04251 C130; C293  LDD0462 
Endoplasmic reticulum metallopeptidase 1 (ERMP1) LDTP08017 C43  LDD0462 
Ephrin type-A receptor 2 (EPHA2) LDTP03474 C842  LDD0462 
Epithelial discoidin domain-containing receptor 1 (DDR1) LDTP05554 C499  LDD0462 
ERO1-like protein alpha (ERO1A) LDTP10386 C241; C131; C166  LDD0462 
Eukaryotic translation initiation factor 2 subunit 3 (EIF2S3) LDTP03915 C434  LDD0462 
Fatty acid CoA ligase Acsl3 (ACSL3) LDTP01634 C450; C429; C85  LDD0462 
Fatty acid synthase (FASN) LDTP04243 C1141  LDD0462 
Fructosamine-3-kinase (FN3K) LDTP11904 C24  LDD0462 
Fructose-bisphosphate aldolase A (ALDOA) LDTP02008 C290; C339; C178  LDD0462 
Glucosamine 6-phosphate N-acetyltransferase (GNPNAT1) LDTP10264 C128  LDD0462 
Glucose-6-phosphatase 3 (G6PC3) LDTP11243 C269  LDD0462 
Glucose-6-phosphate isomerase (GPI) LDTP02162 C404  LDD0462 
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 (GFPT1) LDTP05481 C55  LDD0462 
Glutaryl-CoA dehydrogenase, mitochondrial (GCDH) LDTP09939 C176  LDD0462 
Glutathione S-transferase P (GSTP1) LDTP02333 C170  LDD0462 
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) LDTP02038 C152; C247  LDD0462 
Glycogen synthase kinase-3 beta (GSK3B) LDTP04319 C14  LDD0462 
GTP-binding nuclear protein Ran (RAN) LDTP05007 C112  LDD0462 
GTP-binding protein SAR1a (SAR1A) LDTP12470 C102  LDD0462 
Heme oxygenase 2 (HMOX2) LDTP03540 C265  LDD0462 
Hepatocyte growth factor receptor (MET) LDTP02286 C1021  LDD0462 
Hexokinase-1 (HK1) LDTP02991 C813; C368  LDD0462 
Hexokinase-2 (HK2) LDTP04531 C628; C368  LDD0462 
Histone acetyltransferase type B catalytic subunit (HAT1) LDTP00479 C101  LDD0462 
Holocytochrome c-type synthase (HCCS) LDTP04581 C35  LDD0462 
Hypoxanthine-guanine phosphoribosyltransferase (HPRT1) LDTP01782 C106  LDD0462 
Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) LDTP02611 C331  LDD0462 
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (IDH3A) LDTP04345 C127  LDD0462 
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial (IDH3B) LDTP00885 C233  LDD0462 
Ketosamine-3-kinase (FN3KRP) LDTP16025 C24  LDD0462 
L-lactate dehydrogenase A chain (LDHA) LDTP01766 C293; C163; C131  LDD0462 
L-lactate dehydrogenase B chain (LDHB) LDTP02179 C294  LDD0462 
Leucine--tRNA ligase, cytoplasmic (LARS1) LDTP13056 C522  LDD0462 
Leukotriene A-4 hydrolase (LTA4H) LDTP02385 C200  LDD0462 
Lon protease homolog, mitochondrial (LONP1) LDTP03817 C682  LDD0462 
Lysophospholipid acyltransferase 2 (MBOAT2) LDTP07867 C505  LDD0462 
Lysophospholipid acyltransferase 7 (MBOAT7) LDTP10612 C280  LDD0462 
Macrophage migration inhibitory factor (MIF) LDTP02713 C81  LDD0462 
Malate dehydrogenase, mitochondrial (MDH2) LDTP03908 C128; C212; C89; C93  LDD0462 
Matrix metalloproteinase-14 (MMP14) LDTP04352 C93  LDD0462 
Microsomal glutathione S-transferase 1 (MGST1) LDTP02506 C50  LDD0462 
Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L) LDTP07651 C778  LDD0462 
NAD(P)H-hydrate epimerase (NAXE) LDTP09110 C115; C127  LDD0462 
Nicotinamide phosphoribosyltransferase (NAMPT) LDTP04051 C141  LDD0462 
Non-receptor tyrosine-protein kinase TNK1 (TNK1) LDTP05884 C126  LDD0462 
Nucleoside diphosphate kinase A (NME1) LDTP02796 C109; C145  LDD0462 
Ornithine aminotransferase, mitochondrial (OAT) LDTP02021 C150  LDD0462 
Peptidyl-prolyl cis-trans isomerase A (PPIA) LDTP05028 C161  LDD0462 
Peptidyl-prolyl cis-trans isomerase F, mitochondrial (PPIF) LDTP03534 C104  LDD0462 
Peroxiredoxin-1 (PRDX1) LDTP05503 C173  LDD0462 
Peroxiredoxin-2 (PRDX2) LDTP03626 C172  LDD0462 
Peroxiredoxin-5, mitochondrial (PRDX5) LDTP03512 C204  LDD0462 
Peroxiredoxin-6 (PRDX6) LDTP03510 C91; C47  LDD0462 
Peroxisomal leader peptide-processing protease (TYSND1) LDTP06720 C240  LDD0462 
Phosphatidylserine synthase 1 (PTDSS1) LDTP04203 C419  LDD0462 
Phosphoglucomutase-1 (PGM1) LDTP03818 C101; C160  LDD0462 
Phosphoglycerate kinase 1 (PGK1) LDTP01787 C50; C99; C316; C380  LDD0462 
Phospholipid scramblase 1 (PLSCR1) LDTP00558 C149  LDD0462 
Polypeptide N-acetylgalactosaminyltransferase 3 (GALNT3) LDTP06119 C149; C173  LDD0462 
Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein (ASMTL) LDTP01647 C274  LDD0462 
Prostaglandin E synthase (PTGES) LDTP00407 C137  LDD0462 
Protein disulfide-isomerase A3 (PDIA3) LDTP03521 C244; C92; C85  LDD0462 
Protein disulfide-isomerase A6 (PDIA6) LDTP06314 C291  LDD0462 
Protein NDRG1 (NDRG1) LDTP09810 C253  LDD0462 
Protein phosphatase 1G (PPM1G) LDTP00616 C241  LDD0462 
Protein phosphatase methylesterase 1 (PPME1) LDTP14092 C347  LDD0462 
Protein-glutamine gamma-glutamyltransferase 2 (TGM2) LDTP03146 C370; C230; C620; C545  LDD0462 
Proto-oncogene tyrosine-protein kinase Src (SRC) LDTP02638 C280  LDD0462 
Puromycin-sensitive aminopeptidase (NPEPPS) LDTP04712 C527; C887; C190  LDD0462 
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (PDHB) LDTP02549 C161  LDD0462 
Pyruvate kinase PKM (PKM) LDTP02733 C358; C474  LDD0462 
Ras-related C3 botulinum toxin substrate 1 (RAC1) LDTP05037 C178; C157  LDD0462 
Ras-related C3 botulinum toxin substrate 2 (RAC2) LDTP02768 C157; C178  LDD0462 
Ras-related protein Rab-13 (RAB13) LDTP04401 C123  LDD0462 
Ras-related protein Rap-1b (RAP1B) LDTP04910 C141  LDD0462 
Ras-related protein Rap-2b (RAP2B) LDTP04911 C140  LDD0462 
Receptor-interacting serine/threonine-protein kinase 2 (RIPK2) LDTP00751 C324; C414; C346  LDD0462 
Retinaldehyde dehydrogenase 3 (ALDH1A3) LDTP04134 C381; C467; C164; C61  LDD0462 
Retinol dehydrogenase 10 (RDH10) LDTP08722 C39  LDD0462 
Retinol dehydrogenase 14 (RDH14) LDTP12180 C97  LDD0462 
Rho-associated protein kinase 2 (ROCK2) LDTP01127 C314  LDD0462 
Rho-related GTP-binding protein RhoF (RHOF) LDTP12178 C173  LDD0462 
Rho-related GTP-binding protein RhoG (RHOG) LDTP05195 C157  LDD0462 
Ribosomal protein S6 kinase alpha-1 (RPS6KA1) LDTP06384 C575  LDD0462 
RNA cytidine acetyltransferase (NAT10) LDTP11690 C746; C255  LDD0462 
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) LDTP02860 C447; C997; C344  LDD0462 
Serine hydroxymethyltransferase, mitochondrial (SHMT2) LDTP03689 C119; C91  LDD0462 
Serine/threonine-protein kinase 24 (STK24) LDTP14240 C394  LDD0462 
Serine/threonine-protein kinase N3 (PKN3) LDTP07546 C840  LDD0462 
Serine/threonine-protein kinase RIO2 (RIOK2) LDTP11299 C367  LDD0462 
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PPP2R1A) LDTP03522 C294; C390; C504; C148  LDD0462 
Short-chain dehydrogenase/reductase 3 (DHRS3) LDTP01349 C75  LDD0462 
Signal peptidase complex subunit 2 (SPCS2) LDTP06270 C26; C17  LDD0462 
Small ribosomal subunit protein uS3 (RPS3) LDTP03223 C97  LDD0462 
Sodium/potassium-transporting ATPase subunit alpha-1 (ATP1A1) LDTP02067 C374  LDD0462 
Staphylococcal nuclease domain-containing protein 1 (SND1) LDTP07929 C152  LDD0462 
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial (SUCLA2) LDTP13077 C430  LDD0462 
Succinate-semialdehyde dehydrogenase, mitochondrial (ALDH5A1) LDTP04438 C93  LDD0462 
Telomerase RNA component interacting RNase (TRIR) LDTP11055 C165  LDD0462 
Thioredoxin (TXN) LDTP02502 C73  LDD0462 
Thioredoxin domain-containing protein 5 (TXNDC5) LDTP09067 C121  LDD0462 
Thioredoxin-dependent peroxide reductase, mitochondrial (PRDX3) LDTP03515 C229  LDD0462 
Threonine--tRNA ligase 1, cytoplasmic (TARS1) LDTP03365 C343; C630  LDD0462 
Transcription intermediary factor 1-beta (TRIM28) LDTP05808 C232; C177; C166; C156  LDD0462 
Transforming protein RhoA (RHOA) LDTP04927 C159; C16  LDD0462 
Transitional endoplasmic reticulum ATPase (VCP) LDTP04665 C105; C572; C522  LDD0462 
Translin (TSN) LDTP06427 C225  LDD0462 
Triokinase/FMN cyclase (TKFC) LDTP06779 C404  LDD0462 
Triosephosphate isomerase (TPI1) LDTP04851 C67  LDD0462 
Tripartite motif-containing protein 16 (TRIM16) LDTP01570 C178  LDD0462 
tRNA methyltransferase 10 homolog C (TRMT10C) LDTP07937 C78  LDD0462 
Tubulin alpha-1A chain (TUBA1A) LDTP07907 C4; C347; C200  LDD0462 
Tubulin alpha-1B chain (TUBA1B) LDTP05074 C347  LDD0462 
Tubulin alpha-1C chain (TUBA1C) LDTP11074 C376; C295  LDD0462 
Tubulin alpha-3C chain (TUBA3C) LDTP02452 C295; C376; C305  LDD0462 
Tubulin alpha-4A chain (TUBA4A) LDTP05075 C54  LDD0462 
Tyrosine-protein kinase JAK1 (JAK1) LDTP03230 C731  LDD0462 
Ubiquinone biosynthesis O-methyltransferase, mitochondrial (COQ3) LDTP12908 C155  LDD0462 
Ubiquitin carboxyl-terminal hydrolase 14 (USP14) LDTP04618 C415  LDD0462 
Ubiquitin-conjugating enzyme E2 D1 (UBE2D1) LDTP04442 C85  LDD0462 
Ubiquitin-conjugating enzyme E2 D2 (UBE2D2) LDTP05010 C107  LDD0462 
Ubiquitin-like modifier-activating enzyme 1 (UBA1) LDTP03166 C1039; C632; C234  LDD0462 
Ubiquitin-like modifier-activating enzyme 6 (UBA6) LDTP00013 C347  LDD0462 
Ubiquitin-like-conjugating enzyme ATG3 (ATG3) LDTP12599 C259  LDD0462 
V-type proton ATPase catalytic subunit A (ATP6V1A) LDTP03859 C240  LDD0462 
Valine--tRNA ligase (VARS1) LDTP03366 C41; C682; C112; C917  LDD0462 
Vitamin K epoxide reductase complex subunit 1 (VKORC1) LDTP11070 C43; C51  LDD0462 
Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) LDTP08728 C50  LDD0462 
------------------------------------------------------------------------------------
⏷ Show the Full List of 185 Enzyme
77 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
14-3-3 protein theta (YWHAQ) LDTP03385 C134; C25  LDD0462 
14-3-3 protein zeta/delta (YWHAZ) LDTP05043 C25  LDD0462 
ADP/ATP translocase 1 (SLC25A4) LDTP02608 C257; C129  LDD0462 
ADP/ATP translocase 2 (SLC25A5) LDTP02087 C160; C257  LDD0462 
Annexin A11 (ANXA11) LDTP04393 C226  LDD0462 
Annexin A2 (ANXA2) LDTP02199 C133; C335  LDD0462 
AP-2 complex subunit alpha-1 (AP2A1) LDTP01673 C492  LDD0462 
Cadherin-1 (CDH1) LDTP02634 C695; C688  LDD0462 
Cation-dependent mannose-6-phosphate receptor (M6PR) LDTP03061 C244; C240  LDD0462 
Chloride channel CLIC-like protein 1 (CLCC1) LDTP10804 C254  LDD0462 
Chloride intracellular channel protein 1 (CLIC1) LDTP00244 C223; C178; C89  LDD0462 
Chloride intracellular channel protein 4 (CLIC4) LDTP14222 C234  LDD0462 
Clathrin heavy chain 1 (CLTC) LDTP05252 C491; C926; C328; C1205  LDD0462 
Clathrin heavy chain 2 (CLTCL1) LDTP04578 C459  LDD0462 
Copine-3 (CPNE3) LDTP01133 C506  LDD0462 
Cytochrome c oxidase assembly protein COX20, mitochondrial (COX20) LDTP07053 C29  LDD0462 
Cytoskeleton-associated protein 4 (CKAP4) LDTP05511 C100  LDD0462 
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (RPN1) LDTP02057 C477  LDD0462 
EH domain-containing protein 1 (EHD1) LDTP11934 C138  LDD0462 
Exportin-1 (XPO1) LDTP00501 C119; C164; C327; C34  LDD0462 
Exportin-2 (CSE1L) LDTP04662 C344; C842  LDD0462 
Exportin-5 (XPO5) LDTP12142 C941; C706; C1131  LDD0462 
Exportin-7 (XPO7) LDTP13335 C43; C66  LDD0462 
Exportin-T (XPOT) LDTP00810 C676; C693  LDD0462 
Extended synaptotagmin-1 (ESYT1) LDTP11161 C522  LDD0462 
Fatty acid-binding protein 5 (FABP5) LDTP05292 C67; C87  LDD0462 
Filamin-A (FLNA) LDTP03107 C205; C2293  LDD0462 
Filamin-B (FLNB) LDTP01197 C2248; C178  LDD0462 
Golgi resident protein GCP60 (ACBD3) LDTP11877 C129  LDD0462 
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (GNB1) LDTP05017 C233  LDD0462 
Heat shock protein HSP 90-beta (HSP90AB1) LDTP02262 C590  LDD0462 
High affinity cationic amino acid transporter 1 (SLC7A1) LDTP03559 C628  LDD0462 
Importin subunit alpha-7 (KPNA6) LDTP01031 C253  LDD0462 
Importin subunit beta-1 (KPNB1) LDTP06242 C223; C689; C585  LDD0462 
Importin-4 (IPO4) LDTP09515 C725; C42; C726; C732  LDD0462 
Importin-5 (IPO5) LDTP00266 C972; C682; C473; C1078  LDD0462 
Importin-7 (IPO7) LDTP01574 C757; C736  LDD0462 
Integrin beta-1 (ITGB1) LDTP02122 C301  LDD0462 
Kunitz-type protease inhibitor 2 (SPINT2) LDTP00728 C142; C85  LDD0462 
Leucine-rich repeat-containing protein 59 (LRRC59) LDTP10081 C48; C131; C137  LDD0462 
Low-density lipoprotein receptor (LDLR) LDTP01829 C839  LDD0462 
Lysosome-associated membrane glycoprotein 1 (LAMP1) LDTP02562 C338  LDD0462 
Membrane-associated progesterone receptor component 1 (PGRMC1) LDTP00235 C129  LDD0462 
Membrane-associated progesterone receptor component 2 (PGRMC2) LDTP00562 C159  LDD0462 
MICOS complex subunit MIC26 (APOO) LDTP11250 C71  LDD0462 
Mitochondrial carrier homolog 2 (MTCH2) LDTP14235 C49  LDD0462 
Mitochondrial dicarboxylate carrier (SLC25A10) LDTP13174 C240  LDD0462 
Mitochondrial import receptor subunit TOM40 homolog (TOMM40) LDTP01748 C74; C76  LDD0462 
Mitochondrial potassium channel ATP-binding subunit (ABCB8) LDTP12644 C364  LDD0462 
Mitochondrial thiamine pyrophosphate carrier (SLC25A19) LDTP12210 C222  LDD0462 
Neutral amino acid transporter B(0) (SLC1A5) LDTP06462 C39; C363  LDD0462 
Nuclear pore complex protein Nup85 (NUP85) LDTP11310 C230  LDD0462 
Nucleoporin NDC1 (NDC1) LDTP11213 C468  LDD0462 
PAT complex subunit CCDC47 (CCDC47) LDTP10059 C283  LDD0462 
Peroxisomal biogenesis factor 19 (PEX19) LDTP03905 C128  LDD0462 
Peroxisomal membrane protein PEX13 (PEX13) LDTP09948 C220  LDD0462 
Phospholipid scramblase 3 (PLSCR3) LDTP12548 C126; C214; C125  LDD0462 
Podocalyxin (PODXL) LDTP00321 C395  LDD0462 
Programmed cell death protein 6 (PDCD6) LDTP01180 C155  LDD0462 
Prohibitin 1 (PHB1) LDTP03717 C69  LDD0462 
Protein transport protein Sec61 subunit alpha isoform 1 (SEC61A1) LDTP04932 C13  LDD0462 
Rab5 GDP/GTP exchange factor (RABGEF1) LDTP13369 C181  LDD0462 
Sideroflexin-1 (SFXN1) LDTP12090 C190  LDD0462 
SNARE-associated protein Snapin (SNAPIN) LDTP01558 C66  LDD0462 
Sodium- and chloride-dependent GABA transporter 3 (SLC6A11) LDTP04159 C28  LDD0462 
Solute carrier family 12 member 9 (SLC12A9) LDTP11397 C911  LDD0462 
Sorting nexin-1 (SNX1) LDTP05938 C318  LDD0462 
Stomatin-like protein 2, mitochondrial (STOML2) LDTP13416 C167  LDD0462 
Synaptosomal-associated protein 23 (SNAP23) LDTP00198 C112  LDD0462 
Talin-1 (TLN1) LDTP14031 C1939; C732  LDD0462 
Translocator protein (TSPO) LDTP03546 C19  LDD0462 
Transportin-1 (TNPO1) LDTP09949 C285; C790; C142; C103  LDD0462 
Transportin-3 (TNPO3) LDTP14133 C511  LDD0462 
V-type proton ATPase subunit G 1 (ATP6V1G1) LDTP01185 C69  LDD0462 
Vezatin (VEZT) LDTP12191 C488  LDD0462 
Voltage-dependent anion-selective channel protein 2 (VDAC2) LDTP04071 C210; C47  LDD0462 
Voltage-dependent anion-selective channel protein 3 (VDAC3) LDTP13824 C36  LDD0462 
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⏷ Show the Full List of 77 Transporter and channel
4 Transcription factor Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
eIF5-mimic protein 2 (BZW1) LDTP07940 C35  LDD0462 
Enhancer of rudimentary homolog (ERH) LDTP05194 C28  LDD0462 
Homeobox protein cut-like 1 (CUX1) LDTP03874 C802  LDD0462 
Max-like protein X (MLX) LDTP13255 C159  LDD0462 
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1 GPCR Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Adhesion G protein-coupled receptor E5 (ADGRE5) LDTP04221 C802  LDD0462 
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4 Immunoglobulin Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
HLA class I histocompatibility antigen, A alpha chain (HLA-A) LDTP02040 C363  LDD0462 
HLA class I histocompatibility antigen, B alpha chain (HLA-B) LDTP01913 C349  LDD0462 
Myelin protein zero-like protein 1 (MPZL1) LDTP01559 C203  LDD0462 
Myelin protein zero-like protein 3 (MPZL3) LDTP15152 C215  LDD0462 
------------------------------------------------------------------------------------
1 Cytokine and receptor Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
CKLF-like MARVEL transmembrane domain-containing protein 7 (CMTM7) LDTP10323 C12  LDD0462 
------------------------------------------------------------------------------------
166 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
14-3-3 protein sigma (SFN) LDTP03618 C38  LDD0462 
Acidic leucine-rich nuclear phosphoprotein 32 family member A (ANP32A) LDTP03871 C123  LDD0462 
Actin-related protein 3 (ACTR3) LDTP04902 C408  LDD0462 
Adenylyl cyclase-associated protein 1 (CAP1) LDTP05294 C427  LDD0462 
Alpha-actinin-1 (ACTN1) LDTP02631 C263; C370; C860; C332  LDD0462 
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) LDTP05770 C291  LDD0462 
Ankyrin repeat and KH domain-containing protein 1 (ANKHD1) LDTP08573 C181  LDD0462 
Annexin A3 (ANXA3) LDTP02620 C202  LDD0462 
Annexin A4 (ANXA4) LDTP02354 C108  LDD0462 
Annexin A7 (ANXA7) LDTP03030 C363  LDD0462 
Apoptosis inhibitor 5 (API5) LDTP11575 C234  LDD0462 
BET1 homolog (BET1) LDTP00555 C28  LDD0462 
Beta-catenin-like protein 1 (CTNNBL1) LDTP09733 C370  LDD0462 
Biorientation of chromosomes in cell division protein 1 (BOD1) LDTP10419 C72  LDD0462 
BRCA2 and CDKN1A-interacting protein (BCCIP) LDTP13030 C275  LDD0462 
BSD domain-containing protein 1 (BSDC1) LDTP16116 C49  LDD0462 
Calcium homeostasis endoplasmic reticulum protein (CHERP) LDTP08570 C246  LDD0462 
Calpain small subunit 1 (CAPNS1) LDTP02047 C144  LDD0462 
Calpastatin (CAST) LDTP03079 C408  LDD0462 
Catenin beta-1 (CTNNB1) LDTP03712 C381  LDD0462 
CD99 antigen (CD99) LDTP02715 C154  LDD0462 
Cellular retinoic acid-binding protein 2 (CRABP2) LDTP03482 C82  LDD0462 
Centromere/kinetochore protein zw10 homolog (ZW10) LDTP00720 C568  LDD0462 
Ceramide-1-phosphate transfer protein (CPTP) LDTP07159 C163  LDD0462 
Coatomer subunit beta (COPB1) LDTP04570 C635  LDD0462 
Coatomer subunit gamma-1 (COPG1) LDTP14216 C325  LDD0462 
Cofilin-1 (CFL1) LDTP03244 C139  LDD0462 
Connector enhancer of kinase suppressor of ras 1 (CNKSR1) LDTP10001 C42  LDD0462 
Conserved oligomeric Golgi complex subunit 1 (COG1) LDTP09549 C513  LDD0462 
COP9 signalosome complex subunit 1 (GPS1) LDTP05746 C175  LDD0462 
CYFIP-related Rac1 interactor B (CYRIB) LDTP12642 C223  LDD0462 
Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1) LDTP06083 C4216; C4438; C633  LDD0462 
DnaJ homolog subfamily C member 9 (DNAJC9) LDTP09721 C7  LDD0462 
Dynein axonemal assembly factor 5 (DNAAF5) LDTP08387 C365  LDD0462 
Dynein light chain 1, cytoplasmic (DYNLL1) LDTP05049 C56; C24  LDD0462 
Elongation factor 1-beta (EEF1B2) LDTP03283 C50  LDD0462 
Elongation factor 1-delta (EEF1D) LDTP03499 C217  LDD0462 
Elongation factor 1-gamma (EEF1G) LDTP03367 C194; C210; C266  LDD0462 
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) LDTP13828 C81  LDD0462 
Endoplasmin (HSP90B1) LDTP02734 C576; C645  LDD0462 
Ephrin-B1 (EFNB1) LDTP05222 C314  LDD0462 
Epidermal growth factor receptor kinase substrate 8-like protein 2 (EPS8L2) LDTP11998 C261  LDD0462 
Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1) LDTP02101 C98  LDD0462 
Eukaryotic translation initiation factor 3 subunit E (EIF3E) LDTP04853 C298  LDD0462 
Eukaryotic translation initiation factor 3 subunit K (EIF3K) LDTP13143 C85  LDD0462 
Eukaryotic translation initiation factor 3 subunit L (EIF3L) LDTP13813 C417  LDD0462 
Eukaryotic translation initiation factor 4 gamma 1 (EIF4G1) LDTP05421 C662; C934  LDD0462 
F-actin-capping protein subunit beta (CAPZB) LDTP04127 C206  LDD0462 
Fascin (FSCN1) LDTP06598 C61; C260  LDD0462 
FH1/FH2 domain-containing protein 1 (FHOD1) LDTP14195 C31  LDD0462 
Galectin-1 (LGALS1) LDTP02341 C61; C43  LDD0462 
Guanine nucleotide-binding protein G(i) subunit alpha-2 (GNAI2) LDTP02059 C112  LDD0462 
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 (GNG7) LDTP14469 C39  LDD0462 
Heat shock 70 kDa protein 4 (HSPA4) LDTP03695 C376  LDD0462 
Heterogeneous nuclear ribonucleoprotein K (HNRNPK) LDTP04952 C145; C132  LDD0462 
Heterogeneous nuclear ribonucleoprotein U (HNRNPU) LDTP05259 C648  LDD0462 
Hippocalcin-like protein 1 (HPCAL1) LDTP03841 C185  LDD0462 
Hsp70-binding protein 1 (HSPBP1) LDTP12914 C172  LDD0462 
Integrator complex subunit 1 (INTS1) LDTP08785 C1755  LDD0462 
Integrator complex subunit 15 (INTS15) LDTP18217 C158  LDD0462 
Integrator complex subunit 7 (INTS7) LDTP12678 C42  LDD0462 
Integrin beta-4 (ITGB4) LDTP02829 C742  LDD0462 
Inverted formin-2 (INF2) LDTP06681 C38; C332  LDD0462 
Keratin, type II cuticular Hb1 (KRT81) LDTP06141 C273; C341; C418  LDD0462 
Keratin, type II cytoskeletal 7 (KRT7) LDTP02305 C274  LDD0462 
Lamina-associated polypeptide 2, isoforms beta/gamma (TMPO) LDTP03968 C363  LDD0462 
Large proline-rich protein BAG6 (BAG6) LDTP04094 C869  LDD0462 
Large ribosomal subunit protein eL14 (RPL14) LDTP04389 C42  LDD0462 
Large ribosomal subunit protein P1 (RPLP1) LDTP02107 C61  LDD0462 
Large ribosomal subunit protein uL1 (RPL10A) LDTP05024 C66  LDD0462 
Large ribosomal subunit protein uL10 (RPLP0) LDTP02109 C119  LDD0462 
Large ribosomal subunit protein uL10m (MRPL10) LDTP08154 C180  LDD0462 
Large ribosomal subunit protein uL11 (RPL12) LDTP03517 C141  LDD0462 
Large ribosomal subunit protein uL14 (RPL23) LDTP05008 C28; C125  LDD0462 
Large ribosomal subunit protein uL15 (RPL27A) LDTP04105 C70  LDD0462 
Large ribosomal subunit protein uL16 (RPL10) LDTP03395 C49; C195  LDD0462 
Large ribosomal subunit protein uL18 (RPL5) LDTP04106 C100  LDD0462 
Large ribosomal subunit protein uL3 (RPL3) LDTP03865 C114; C253  LDD0462 
Large ribosomal subunit protein uL4 (RPL4) LDTP03815 C96  LDD0462 
Leucine-rich PPR motif-containing protein, mitochondrial (LRPPRC) LDTP03997 C500; C484; C208; C571  LDD0462 
Lipase maturation factor 2 (LMF2) LDTP15887 C696  LDD0462 
Luc7-like protein 3 (LUC7L3) LDTP01534 C58  LDD0462 
MICOS complex subunit MIC13 (MICOS13) LDTP07274 C60  LDD0462 
Mitochondrial antiviral-signaling protein (MAVS) LDTP08058 C20  LDD0462 
Mitochondrial import inner membrane translocase subunit Tim8 B (TIMM8B) LDTP16322 C55  LDD0462 
Mitochondrial import receptor subunit TOM70 (TOMM70) LDTP01432 C136  LDD0462 
MMS19 nucleotide excision repair protein homolog (MMS19) LDTP10843 C549  LDD0462 
MTOR-associated protein MEAK7 (MEAK7) LDTP07550 C13  LDD0462 
Myb-binding protein 1A (MYBBP1A) LDTP11079 C942; C968; C338; C109  LDD0462 
NADH dehydrogenase 1 alpha subcomplex assembly factor 4 (NDUFAF4) LDTP12953 C87  LDD0462 
Neuroblast differentiation-associated protein AHNAK (AHNAK) LDTP05597 C2806; C108  LDD0462 
Neutrophil gelatinase-associated lipocalin (LCN2) LDTP05156 C195  LDD0462 
Nuclear migration protein nudC (NUDC) LDTP13817 C188  LDD0462 
Nucleolar protein 56 (NOP56) LDTP00313 C384; C52  LDD0462 
OCIA domain-containing protein 2 (OCIAD2) LDTP17157 C134; C27  LDD0462 
Oxysterol-binding protein-related protein 3 (OSBPL3) LDTP11930 C520  LDD0462 
Pentatricopeptide repeat-containing protein 1, mitochondrial (PTCD1) LDTP01130 C218  LDD0462 
Perilipin-3 (PLIN3) LDTP01021 C60; C341  LDD0462 
Pituitary tumor-transforming gene 1 protein-interacting protein (PTTG1IP) LDTP04586 C81  LDD0462 
Plastin-2 (LCP1) LDTP02691 C164  LDD0462 
Plastin-3 (PLS3) LDTP02692 C167  LDD0462 
Plectin (PLEC) LDTP06330 C3299; C3493  LDD0462 
Poly(rC)-binding protein 1 (PCBP1) LDTP06366 C109; C54  LDD0462 
Poly(rC)-binding protein 2 (PCBP2) LDTP06367 C109  LDD0462 
Pre-rRNA-processing protein TSR2 homolog (TSR2) LDTP09989 C17  LDD0462 
Proliferating cell nuclear antigen (PCNA) LDTP02596 C135; C162  LDD0462 
Proline-rich protein 11 (PRR11) LDTP15734 C120  LDD0462 
Proteasome activator complex subunit 1 (PSME1) LDTP05484 C106; C101  LDD0462 
Proteasome activator complex subunit 2 (PSME2) LDTP13519 C91  LDD0462 
Protein C10 (C12orf57) LDTP10923 C44  LDD0462 
Protein FAM136A (FAM136A) LDTP18132 C40  LDD0462 
Protein FAM210B, mitochondrial (FAM210B) LDTP10519 C77  LDD0462 
Protein Hook homolog 1 (HOOK1) LDTP13383 C31  LDD0462 
Protein odr-4 homolog (ODR4) LDTP17214 C77  LDD0462 
Protein phosphatase 1 regulatory subunit 21 (PPP1R21) LDTP07768 C750  LDD0462 
Protein S100-A11 (S100A11) LDTP03620 C13; C91  LDD0462 
Protein S100-A14 (S100A14) LDTP12277 C74; C62  LDD0462 
Protein SAAL1 (SAAL1) LDTP18152 C248  LDD0462 
Protein ZNRD2 (ZNRD2) LDTP00916 C152  LDD0462 
Rab GDP dissociation inhibitor alpha (GDI1) LDTP03574 C202  LDD0462 
Rab GDP dissociation inhibitor beta (GDI2) LDTP04355 C202  LDD0462 
Ras GTPase-activating-like protein IQGAP1 (IQGAP1) LDTP04117 C660; C45  LDD0462 
Reticulon-4 (RTN4) LDTP12412 C1101  LDD0462 
Rho GDP-dissociation inhibitor 1 (ARHGDIA) LDTP04510 C79  LDD0462 
Ribonuclease inhibitor (RNH1) LDTP02656 C95  LDD0462 
RRP12-like protein (RRP12) LDTP14980 C673  LDD0462 
Serine/arginine-rich splicing factor 1 (SRSF1) LDTP05539 C148  LDD0462 
Serine/threonine-protein phosphatase 6 regulatory subunit 3 (PPP6R3) LDTP06983 C216  LDD0462 
Serpin B5 (SERPINB5) LDTP03825 C20  LDD0462 
Sister chromatid cohesion protein PDS5 homolog A (PDS5A) LDTP06684 C581; C532  LDD0462 
SLAIN motif-containing protein 2 (SLAIN2) LDTP13023 C165  LDD0462 
Small glutamine-rich tetratricopeptide repeat-containing protein alpha (SGTA) LDTP00862 C153  LDD0462 
Small ribosomal subunit protein eS12 (RPS12) LDTP03321 C69; C50; C108; C56  LDD0462 
Small ribosomal subunit protein eS6 (RPS6) LDTP05002 C12  LDD0462 
Small ribosomal subunit protein uS10 (RPS20) LDTP04880 C70  LDD0462 
Small ribosomal subunit protein uS12 (RPS23) LDTP04971 C90  LDD0462 
Small ribosomal subunit protein uS17 (RPS11) LDTP04975 C131  LDD0462 
Small ribosomal subunit protein uS2 (RPSA) LDTP02312 C148  LDD0462 
Small ribosomal subunit protein uS5 (RPS2) LDTP02809 C222; C229  LDD0462 
Small ribosomal subunit protein uS7 (RPS5) LDTP04110 C66; C172; C155  LDD0462 
Small ribosomal subunit protein uS9 (RPS16) LDTP04966 C25  LDD0462 
Spectrin alpha chain, non-erythrocytic 1 (SPTAN1) LDTP05985 C1622; C2441  LDD0462 
Splicing factor 3A subunit 1 (SF3A1) LDTP06393 C244  LDD0462 
Splicing factor 3B subunit 1 (SF3B1) LDTP01251 C1035  LDD0462 
Squamous cell carcinoma antigen recognized by T-cells 3 (SART3) LDTP06280 C341  LDD0462 
Stalled ribosome sensor GCN1 (GCN1) LDTP09821 C1362; C1482; C2015; C1527  LDD0462 
Stress-70 protein, mitochondrial (HSPA9) LDTP03860 C317  LDD0462 
T-complex protein 1 subunit alpha (TCP1) LDTP02934 C147  LDD0462 
T-complex protein 1 subunit epsilon (CCT5) LDTP04201 C253; C302  LDD0462 
T-complex protein 1 subunit eta (CCT7) LDTP10990 C450; C29  LDD0462 
T-complex protein 1 subunit theta (CCT8) LDTP04390 C148; C430  LDD0462 
Telomere-associated protein RIF1 (RIF1) LDTP07205 C312  LDD0462 
Tetraspanin-31 (TSPAN31) LDTP14827 C3  LDD0462 
Transgelin-2 (TAGLN2) LDTP03846 C124; C38; C63  LDD0462 
Translationally-controlled tumor protein (TPT1) LDTP02683 C28  LDD0462 
Transmembrane protein 248 (TMEM248) LDTP12712 C305  LDD0462 
Tubulin beta 8B (TUBB8B) LDTP00119 C129; C127  LDD0462 
Tubulin beta chain (TUBB) LDTP02205 C201; C354; C12  LDD0462 
Tubulin beta-2A chain (TUBB2A) LDTP05998 C239; C354; C129; C211  LDD0462 
Tubulin beta-3 chain (TUBB3) LDTP05904 C211; C201  LDD0462 
Tubulin beta-4B chain (TUBB4B) LDTP05076 C239; C354; C303; C201  LDD0462 
Ubiquitin-ribosomal protein eS31 fusion protein (RPS27A) LDTP05033 C121  LDD0462 
Vasodilator-stimulated phosphoprotein (VASP) LDTP04372 C334  LDD0462 
Vesicle transport protein SFT2C (SFT2D3) LDTP19324 C67  LDD0462 
Vinculin (VCL) LDTP02946 C1018  LDD0462 
Zinc finger protein-like 1 (ZFPL1) LDTP01510 C230  LDD0462 
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⏷ Show the Full List of 166 Other

Competitor(s) Related To This Probe

Competitor ID Name Concentration Cell-system Ref
 LDCM0179  JZ128 5 uM Human prostate carcinoma cell lysate (PC-3) [1]

Full Information of The Labelling Profiles of This Probe

Quantification: Probe vs (Probe+Competitor)
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
2 uM
Quantitative Method
iTRAQ
Competitor Name
JZ128
 Competitor Info 
Competitor Concentration
5 uM
In Vitro Experiment Model
Model Type
Cell lysate
Derived Tissue
Prostate
Disease Model
Prostate carcinoma [ICD-11:2C82]
Model Name
Human prostate carcinoma cell lysate (PC-3)
Interaction Atlas ID
 LDD0462 
Download The Altas

References

1 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.