Details of the Target

General Information of Target

Target ID LDTP04393
Target Name Annexin A11 (ANXA11)
Gene Name ANXA11
Gene ID 311
Synonyms
ANX11; Annexin A11; 56 kDa autoantigen; Annexin XI; Annexin-11; Calcyclin-associated annexin 50; CAP-50
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSYPGYPPPPGGYPPAAPGGGPWGGAAYPPPPSMPPIGLDNVATYAGQFNQDYLSGMAAN
MSGTFGGANMPNLYPGAPGAGYPPVPPGGFGQPPSAQQPVPPYGMYPPPGGNPPSRMPSY
PPYPGAPVPGQPMPPPGQQPPGAYPGQPPVTYPGQPPVPLPGQQQPVPSYPGYPGSGTVT
PAVPPTQFGSRGTITDAPGFDPLRDAEVLRKAMKGFGTDEQAIIDCLGSRSNKQRQQILL
SFKTAYGKDLIKDLKSELSGNFEKTILALMKTPVLFDIYEIKEAIKGVGTDEACLIEILA
SRSNEHIRELNRAYKAEFKKTLEEAIRSDTSGHFQRLLISLSQGNRDESTNVDMSLAQRD
AQELYAAGENRLGTDESKFNAVLCSRSRAHLVAVFNEYQRMTGRDIEKSICREMSGDLEE
GMLAVVKCLKNTPAFFAERLNKAMRGAGTKDRTLIRIMVSRSETDLLDIRSEYKRMYGKS
LYHDISGDTSGDYRKILLKICGGND
Target Bioclass
Transporter and channel
Family
Annexin family
Subcellular location
Cytoplasm
Function Binds specifically to calcyclin in a calcium-dependent manner. Required for midbody formation and completion of the terminal phase of cytokinesis.
Uniprot ID
P50995
Ensemble ID
ENST00000265447.8
HGNC ID
HGNC:535

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
IGROV1 Deletion: p.I37SfsTer114 DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER SNV: p.P109T DBIA    Probe Info 
JHH7 SNV: p.R456C .
OVCAR4 SNV: p.P109S DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 37 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		7.25  LDD0402  [1]
P8
 Probe Info  		10.00  LDD0451  [2]
TG42
 Probe Info  		8.15  LDD0326  [3]
TH211
 Probe Info  		Y365(20.00); Y398(20.00); Y493(20.00); Y279(15.59)  LDD0260  [4]
TH216
 Probe Info  		Y398(7.88)  LDD0259  [4]
YN-1
 Probe Info  		100.00  LDD0444  [5]
ONAyne
 Probe Info  		K408(0.92); K450(0.83)  LDD0274  [6]
STPyne
 Probe Info  		K255(6.52); K315(5.26); K378(6.62); K408(9.92)  LDD0277  [6]
Probe 1
 Probe Info  		Y365(13.12)  LDD3495  [7]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [8]
BTD
 Probe Info  		C384(0.52)  LDD2091  [9]
DBIA
 Probe Info  		C384(7.38)  LDD0209  [10]
HHS-475
 Probe Info  		Y482(0.52); Y365(0.93)  LDD0264  [11]
TFBX
 Probe Info  		C384(3.87)  LDD0312  [12]
HHS-465
 Probe Info  		Y279(3.59)  LDD2237  [13]
5E-2FA
 Probe Info  		H333(0.00); H483(0.00)  LDD2235  [14]
ATP probe
 Probe Info  		N.A.  LDD0199  [15]
4-Iodoacetamidophenylacetylene
 Probe Info  		C384(0.00); C226(0.00); C294(0.00)  LDD0038  [16]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [17]
IPIAA_H
 Probe Info  		C294(0.00); C226(0.00)  LDD0030  [18]
IPIAA_L
 Probe Info  		C226(0.00); C294(0.00)  LDD0031  [18]
Lodoacetamide azide
 Probe Info  		C384(0.00); C226(0.00); C294(0.00)  LDD0037  [16]
ATP probe
 Probe Info  		N.A.  LDD0035  [19]
IPM
 Probe Info  		N.A.  LDD0025  [12]
NAIA_4
 Probe Info  		N.A.  LDD2226  [20]
WYneN
 Probe Info  		C294(0.00); C384(0.00)  LDD0021  [21]
Compound 10
 Probe Info  		C294(0.00); C384(0.00)  LDD2216  [22]
Compound 11
 Probe Info  		N.A.  LDD2213  [22]
SF
 Probe Info  		N.A.  LDD0028  [23]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [24]
1c-yne
 Probe Info  		K264(0.00); K271(0.00)  LDD0228  [25]
Acrolein
 Probe Info  		C226(0.00); C294(0.00); H483(0.00); C384(0.00)  LDD0217  [26]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [26]
Methacrolein
 Probe Info  		C226(0.00); C294(0.00); C384(0.00)  LDD0218  [26]
W1
 Probe Info  		C384(0.00); C294(0.00); S328(0.00)  LDD0236  [27]
AOyne
 Probe Info  		8.60  LDD0443  [28]
NAIA_5
 Probe Info  		C384(0.00); C294(0.00); C226(0.00)  LDD2223  [20]
PAL-AfBPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C153
 Probe Info  		14.93  LDD1834  [29]
FFF probe11
 Probe Info  		9.18  LDD0471  [30]
FFF probe13
 Probe Info  		14.53  LDD0475  [30]
FFF probe14
 Probe Info  		20.00  LDD0477  [30]
FFF probe2
 Probe Info  		20.00  LDD0463  [30]
FFF probe3
 Probe Info  		10.77  LDD0464  [30]
JN0003
 Probe Info  		12.41  LDD0469  [30]
STS-1
 Probe Info  		7.83  LDD0136  [31]
STS-2
 Probe Info  		6.50  LDD0138  [31]
VE-P
 Probe Info  		N.A.  LDD0396  [32]
Staurosporine capture compound
 Probe Info  		2.00  LDD0083  [33]
OEA-DA
 Probe Info  		3.58  LDD0046  [34]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C384(0.65)  LDD2117  [9]
 LDCM0563  Abegg_cp(+)-11 HeLa C384(3.22)  LDD0314  [12]
 LDCM0561  Abegg_cp(-)-10 HeLa C384(3.87)  LDD0312  [12]
 LDCM0562  Abegg_cp(-)-11 HeLa C384(4.51)  LDD0313  [12]
 LDCM0214  AC1 HCT 116 C226(1.16); C294(0.89); C384(1.24)  LDD0531  [35]
 LDCM0215  AC10 HCT 116 C226(1.22); C294(0.94); C384(1.33)  LDD0532  [35]
 LDCM0216  AC100 HCT 116 C226(1.08); C294(1.15); C384(0.67)  LDD0533  [35]
 LDCM0217  AC101 HCT 116 C226(0.83); C294(1.01); C384(0.65)  LDD0534  [35]
 LDCM0218  AC102 HCT 116 C226(1.11); C294(1.05); C384(0.62)  LDD0535  [35]
 LDCM0219  AC103 HCT 116 C226(0.92); C294(0.95); C384(0.63)  LDD0536  [35]
 LDCM0220  AC104 HCT 116 C226(1.12); C294(1.05); C384(0.62)  LDD0537  [35]
 LDCM0221  AC105 HCT 116 C226(1.01); C294(1.04); C384(0.62)  LDD0538  [35]
 LDCM0222  AC106 HCT 116 C226(1.14); C294(0.98); C384(0.63)  LDD0539  [35]
 LDCM0223  AC107 HCT 116 C226(1.05); C294(1.05); C384(0.70)  LDD0540  [35]
 LDCM0224  AC108 HCT 116 C226(0.97); C294(0.96); C384(0.78)  LDD0541  [35]
 LDCM0225  AC109 HCT 116 C226(1.21); C294(1.04); C384(0.76)  LDD0542  [35]
 LDCM0226  AC11 HCT 116 C226(1.14); C294(0.96); C384(1.05)  LDD0543  [35]
 LDCM0227  AC110 HCT 116 C226(0.97); C294(0.92); C384(0.68)  LDD0544  [35]
 LDCM0228  AC111 HCT 116 C226(0.81); C294(0.95); C384(0.66)  LDD0545  [35]
 LDCM0229  AC112 HCT 116 C226(0.87); C294(0.99); C384(0.64)  LDD0546  [35]
 LDCM0230  AC113 HCT 116 C226(1.07); C294(1.06); C384(1.04)  LDD0547  [35]
 LDCM0231  AC114 HCT 116 C226(1.03); C294(0.89); C384(0.95)  LDD0548  [35]
 LDCM0232  AC115 HCT 116 C226(1.11); C294(0.99); C384(0.91)  LDD0549  [35]
 LDCM0233  AC116 HCT 116 C226(1.04); C294(0.97); C384(0.86)  LDD0550  [35]
 LDCM0234  AC117 HCT 116 C226(1.11); C294(0.99); C384(1.12)  LDD0551  [35]
 LDCM0235  AC118 HCT 116 C226(1.13); C294(1.12); C384(1.04)  LDD0552  [35]
 LDCM0236  AC119 HCT 116 C226(1.17); C294(1.01); C384(0.97)  LDD0553  [35]
 LDCM0237  AC12 HCT 116 C226(1.25); C294(1.09); C384(1.08)  LDD0554  [35]
 LDCM0238  AC120 HCT 116 C226(1.33); C294(0.84); C384(0.99)  LDD0555  [35]
 LDCM0239  AC121 HCT 116 C226(0.83); C294(0.95); C384(1.22)  LDD0556  [35]
 LDCM0240  AC122 HCT 116 C226(0.95); C294(1.12); C384(1.20)  LDD0557  [35]
 LDCM0241  AC123 HCT 116 C226(0.88); C294(1.08); C384(1.45)  LDD0558  [35]
 LDCM0242  AC124 HCT 116 C226(0.92); C294(1.10); C384(1.15)  LDD0559  [35]
 LDCM0243  AC125 HCT 116 C226(1.06); C294(0.97); C384(1.06)  LDD0560  [35]
 LDCM0244  AC126 HCT 116 C226(1.08); C294(0.96); C384(1.24)  LDD0561  [35]
 LDCM0245  AC127 HCT 116 C226(1.02); C294(1.01); C384(1.22)  LDD0562  [35]
 LDCM0246  AC128 HCT 116 C226(1.83); C294(0.93); C384(1.22)  LDD0563  [35]
 LDCM0247  AC129 HCT 116 C226(0.86); C294(0.99); C384(1.25)  LDD0564  [35]
 LDCM0249  AC130 HCT 116 C226(0.72); C294(0.93); C384(1.04)  LDD0566  [35]
 LDCM0250  AC131 HCT 116 C226(0.81); C294(1.34); C384(0.94)  LDD0567  [35]
 LDCM0251  AC132 HCT 116 C226(0.69); C294(0.98); C384(1.06)  LDD0568  [35]
 LDCM0252  AC133 HCT 116 C226(0.83); C294(0.87); C384(1.10)  LDD0569  [35]
 LDCM0253  AC134 HCT 116 C226(0.72); C294(0.97); C384(0.91)  LDD0570  [35]
 LDCM0254  AC135 HCT 116 C226(0.78); C294(1.04); C384(0.94)  LDD0571  [35]
 LDCM0255  AC136 HCT 116 C226(0.64); C294(0.92); C384(0.93)  LDD0572  [35]
 LDCM0256  AC137 HCT 116 C226(0.55); C294(1.10); C384(0.99)  LDD0573  [35]
 LDCM0257  AC138 HCT 116 C226(0.80); C294(0.87); C384(1.12)  LDD0574  [35]
 LDCM0258  AC139 HCT 116 C226(0.59); C294(0.85); C384(0.97)  LDD0575  [35]
 LDCM0259  AC14 HCT 116 C226(1.06); C294(1.08); C384(0.99)  LDD0576  [35]
 LDCM0260  AC140 HCT 116 C226(0.59); C294(0.96); C384(1.01)  LDD0577  [35]
 LDCM0261  AC141 HCT 116 C226(0.69); C294(0.92); C384(0.96)  LDD0578  [35]
 LDCM0262  AC142 HCT 116 C226(0.55); C294(0.97); C384(0.91)  LDD0579  [35]
 LDCM0263  AC143 HCT 116 C226(0.82); C294(0.96); C384(1.06)  LDD0580  [35]
 LDCM0264  AC144 HCT 116 C384(0.88); C226(1.19); C294(1.37)  LDD0581  [35]
 LDCM0265  AC145 HCT 116 C294(0.86); C384(1.14); C226(1.52)  LDD0582  [35]
 LDCM0266  AC146 HCT 116 C294(0.94); C384(0.95); C226(1.32)  LDD0583  [35]
 LDCM0267  AC147 HCT 116 C294(0.76); C384(0.88); C226(1.33)  LDD0584  [35]
 LDCM0268  AC148 HCT 116 C294(0.81); C384(1.04); C226(1.28)  LDD0585  [35]
 LDCM0269  AC149 HCT 116 C294(0.68); C384(0.90); C226(0.94)  LDD0586  [35]
 LDCM0270  AC15 HCT 116 C294(0.97); C226(1.09); C384(1.25)  LDD0587  [35]
 LDCM0271  AC150 HCT 116 C384(0.96); C294(1.23); C226(1.34)  LDD0588  [35]
 LDCM0272  AC151 HCT 116 C384(0.88); C226(1.16); C294(2.41)  LDD0589  [35]
 LDCM0273  AC152 HCT 116 C384(0.96); C226(0.97); C294(2.05)  LDD0590  [35]
 LDCM0274  AC153 HCT 116 C294(0.84); C384(1.13); C226(1.25)  LDD0591  [35]
 LDCM0621  AC154 HCT 116 C226(1.68); C294(1.55); C384(0.98)  LDD2158  [35]
 LDCM0622  AC155 HCT 116 C226(1.60); C294(1.84); C384(1.05)  LDD2159  [35]
 LDCM0623  AC156 HCT 116 C226(1.15); C294(1.30); C384(1.02)  LDD2160  [35]
 LDCM0624  AC157 HCT 116 C226(1.17); C294(2.27); C384(1.21)  LDD2161  [35]
 LDCM0276  AC17 HCT 116 C226(1.21); C294(1.24); C384(1.25)  LDD0593  [35]
 LDCM0277  AC18 HCT 116 C294(1.19); C384(1.21); C226(1.29)  LDD0594  [35]
 LDCM0278  AC19 HCT 116 C294(1.11); C384(1.15); C226(1.31)  LDD0595  [35]
 LDCM0279  AC2 HCT 116 C294(0.91); C226(0.99); C384(1.08)  LDD0596  [35]
 LDCM0280  AC20 HCT 116 C294(1.08); C384(1.15); C226(1.20)  LDD0597  [35]
 LDCM0281  AC21 HCT 116 C294(1.14); C384(1.25); C226(1.41)  LDD0598  [35]
 LDCM0282  AC22 HCT 116 C226(1.16); C384(1.21); C294(1.22)  LDD0599  [35]
 LDCM0283  AC23 HCT 116 C226(1.22); C294(1.25); C384(1.33)  LDD0600  [35]
 LDCM0284  AC24 HCT 116 C384(1.21); C226(1.28); C294(1.28)  LDD0601  [35]
 LDCM0285  AC25 HCT 116 C226(0.80); C294(0.84); C384(1.28)  LDD0602  [35]
 LDCM0286  AC26 HCT 116 C294(0.67); C226(0.78); C384(0.97)  LDD0603  [35]
 LDCM0287  AC27 HCT 116 C294(0.72); C226(0.92); C384(0.96)  LDD0604  [35]
 LDCM0288  AC28 HCT 116 C294(0.71); C226(0.93); C384(0.96)  LDD0605  [35]
 LDCM0289  AC29 HCT 116 C294(0.73); C226(0.79); C384(0.84)  LDD0606  [35]
 LDCM0290  AC3 HCT 116 C226(0.95); C294(0.96); C384(1.06)  LDD0607  [35]
 LDCM0291  AC30 HCT 116 C294(0.67); C384(0.85); C226(0.99)  LDD0608  [35]
 LDCM0292  AC31 HCT 116 C294(0.70); C384(0.93); C226(1.02)  LDD0609  [35]
 LDCM0293  AC32 HCT 116 C226(0.60); C294(0.69); C384(0.92)  LDD0610  [35]
 LDCM0294  AC33 HCT 116 C226(0.79); C294(0.82); C384(0.97)  LDD0611  [35]
 LDCM0295  AC34 HCT 116 C226(0.73); C294(0.87); C384(0.97)  LDD0612  [35]
 LDCM0296  AC35 HCT 116 C384(1.22); C226(1.31)  LDD0613  [35]
 LDCM0297  AC36 HCT 116 C384(0.99); C226(1.07)  LDD0614  [35]
 LDCM0298  AC37 HCT 116 C384(1.07); C226(1.13)  LDD0615  [35]
 LDCM0299  AC38 HCT 116 C226(0.94); C384(0.95)  LDD0616  [35]
 LDCM0300  AC39 HCT 116 C226(1.19); C384(1.24)  LDD0617  [35]
 LDCM0301  AC4 HCT 116 C294(0.96); C384(1.13); C226(1.19)  LDD0618  [35]
 LDCM0302  AC40 HCT 116 C384(0.96); C226(1.01)  LDD0619  [35]
 LDCM0303  AC41 HCT 116 C226(0.76); C384(0.93)  LDD0620  [35]
 LDCM0304  AC42 HCT 116 C226(0.94); C384(1.05)  LDD0621  [35]
 LDCM0305  AC43 HCT 116 C226(0.87); C384(0.90)  LDD0622  [35]
 LDCM0306  AC44 HCT 116 C226(0.97); C384(1.04)  LDD0623  [35]
 LDCM0307  AC45 HCT 116 C226(0.99); C384(1.02)  LDD0624  [35]
 LDCM0308  AC46 HCT 116 C226(0.63); C384(0.79); C294(0.90)  LDD0625  [35]
 LDCM0309  AC47 HCT 116 C226(0.68); C294(0.85); C384(0.86)  LDD0626  [35]
 LDCM0310  AC48 HCT 116 C226(0.56); C384(0.89); C294(0.99)  LDD0627  [35]
 LDCM0311  AC49 HCT 116 C226(0.55); C384(0.80); C294(0.85)  LDD0628  [35]
 LDCM0312  AC5 HCT 116 C294(0.88); C226(1.14); C384(1.17)  LDD0629  [35]
 LDCM0313  AC50 HCT 116 C226(0.62); C384(0.86); C294(0.86)  LDD0630  [35]
 LDCM0314  AC51 HCT 116 C226(0.59); C384(0.96); C294(1.01)  LDD0631  [35]
 LDCM0315  AC52 HCT 116 C226(0.62); C294(0.80); C384(0.99)  LDD0632  [35]
 LDCM0316  AC53 HCT 116 C294(0.76); C226(0.80); C384(0.94)  LDD0633  [35]
 LDCM0317  AC54 HCT 116 C226(0.60); C294(0.95); C384(1.06)  LDD0634  [35]
 LDCM0318  AC55 HCT 116 C294(0.86); C384(1.22); C226(1.45)  LDD0635  [35]
 LDCM0319  AC56 HCT 116 C226(0.78); C294(0.81); C384(0.91)  LDD0636  [35]
 LDCM0320  AC57 HCT 116 C294(0.99); C226(1.11); C384(1.19)  LDD0637  [35]
 LDCM0321  AC58 HCT 116 C294(0.90); C384(0.91); C226(1.47)  LDD0638  [35]
 LDCM0322  AC59 HCT 116 C294(0.87); C384(1.05); C226(1.25)  LDD0639  [35]
 LDCM0323  AC6 HCT 116 C294(0.91); C226(0.99); C384(1.07)  LDD0640  [35]
 LDCM0324  AC60 HCT 116 C294(0.83); C384(0.85); C226(1.08)  LDD0641  [35]
 LDCM0325  AC61 HCT 116 C294(0.82); C384(0.93); C226(1.18)  LDD0642  [35]
 LDCM0326  AC62 HCT 116 C294(0.82); C384(1.09); C226(1.35)  LDD0643  [35]
 LDCM0327  AC63 HCT 116 C294(0.80); C384(1.05); C226(1.14)  LDD0644  [35]
 LDCM0328  AC64 HCT 116 C294(0.81); C384(1.07); C226(1.60)  LDD0645  [35]
 LDCM0329  AC65 HCT 116 C226(0.94); C294(0.97); C384(1.06)  LDD0646  [35]
 LDCM0330  AC66 HCT 116 C294(0.93); C384(1.07); C226(1.13)  LDD0647  [35]
 LDCM0331  AC67 HCT 116 C384(0.90); C294(0.99); C226(1.02)  LDD0648  [35]
 LDCM0332  AC68 HCT 116 C294(0.82); C226(0.91); C384(1.04)  LDD0649  [35]
 LDCM0333  AC69 HCT 116 C294(0.90); C226(1.10); C384(1.12)  LDD0650  [35]
 LDCM0334  AC7 HCT 116 C294(0.98); C226(1.09); C384(1.14)  LDD0651  [35]
 LDCM0335  AC70 HCT 116 C294(0.79); C226(0.81); C384(1.03)  LDD0652  [35]
 LDCM0336  AC71 HCT 116 C226(0.85); C294(0.93); C384(1.16)  LDD0653  [35]
 LDCM0337  AC72 HCT 116 C294(0.92); C226(0.97); C384(1.11)  LDD0654  [35]
 LDCM0338  AC73 HCT 116 C294(0.96); C226(1.05); C384(1.17)  LDD0655  [35]
 LDCM0339  AC74 HCT 116 C226(1.01); C294(1.06); C384(1.16)  LDD0656  [35]
 LDCM0340  AC75 HCT 116 C226(0.99); C294(1.00); C384(1.21)  LDD0657  [35]
 LDCM0341  AC76 HCT 116 C294(0.91); C226(1.02); C384(1.32)  LDD0658  [35]
 LDCM0342  AC77 HCT 116 C294(0.83); C226(0.87); C384(1.07)  LDD0659  [35]
 LDCM0343  AC78 HCT 116 C294(0.85); C226(0.89); C384(1.04)  LDD0660  [35]
 LDCM0344  AC79 HCT 116 C294(0.96); C384(1.08); C226(1.14)  LDD0661  [35]
 LDCM0345  AC8 HCT 116 C226(0.94); C294(1.00); C384(1.06)  LDD0662  [35]
 LDCM0346  AC80 HCT 116 C294(0.90); C226(0.92); C384(1.13)  LDD0663  [35]
 LDCM0347  AC81 HCT 116 C294(0.89); C226(1.22); C384(1.31)  LDD0664  [35]
 LDCM0348  AC82 HCT 116 C294(1.04); C226(1.12); C384(1.23)  LDD0665  [35]
 LDCM0349  AC83 HCT 116 C226(0.67); C384(0.91); C294(0.98)  LDD0666  [35]
 LDCM0350  AC84 HCT 116 C226(0.60); C294(0.87); C384(1.00)  LDD0667  [35]
 LDCM0351  AC85 HCT 116 C226(0.60); C294(0.78); C384(1.00)  LDD0668  [35]
 LDCM0352  AC86 HCT 116 C226(0.67); C294(0.86); C384(1.04)  LDD0669  [35]
 LDCM0353  AC87 HCT 116 C226(0.81); C294(0.92); C384(1.06)  LDD0670  [35]
 LDCM0354  AC88 HCT 116 C226(0.72); C294(0.87); C384(1.07)  LDD0671  [35]
 LDCM0355  AC89 HCT 116 C226(0.64); C294(0.85); C384(0.91)  LDD0672  [35]
 LDCM0357  AC90 HCT 116 C226(0.95); C384(1.03); C294(1.18)  LDD0674  [35]
 LDCM0358  AC91 HCT 116 C226(0.70); C294(0.89); C384(1.10)  LDD0675  [35]
 LDCM0359  AC92 HCT 116 C226(0.70); C294(0.81); C384(1.11)  LDD0676  [35]
 LDCM0360  AC93 HCT 116 C226(0.69); C294(0.82); C384(1.15)  LDD0677  [35]
 LDCM0361  AC94 HCT 116 C294(0.78); C226(0.84); C384(1.35)  LDD0678  [35]
 LDCM0362  AC95 HCT 116 C226(0.69); C294(0.76); C384(1.09)  LDD0679  [35]
 LDCM0363  AC96 HCT 116 C226(0.73); C294(0.77); C384(1.33)  LDD0680  [35]
 LDCM0364  AC97 HCT 116 C226(0.63); C294(0.86); C384(0.96)  LDD0681  [35]
 LDCM0365  AC98 HCT 116 C384(0.69); C226(0.82); C294(1.04)  LDD0682  [35]
 LDCM0366  AC99 HCT 116 C384(0.71); C226(0.83); C294(1.04)  LDD0683  [35]
 LDCM0248  AKOS034007472 HCT 116 C226(1.24); C294(0.93); C384(0.91)  LDD0565  [35]
 LDCM0356  AKOS034007680 HCT 116 C384(0.99); C294(1.02); C226(1.03)  LDD0673  [35]
 LDCM0275  AKOS034007705 HCT 116 C294(0.95); C226(0.98); C384(1.04)  LDD0592  [35]
 LDCM0156  Aniline NCI-H1299 11.33  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C226(1.03)  LDD2171  [35]
 LDCM0498  BS-3668 MDA-MB-231 C384(0.52)  LDD2091  [9]
 LDCM0108  Chloroacetamide HeLa C226(0.00); C294(0.00); H483(0.00); H333(0.00)  LDD0222  [26]
 LDCM0367  CL1 HCT 116 C294(0.94); C384(0.96); C226(1.07)  LDD0684  [35]
 LDCM0368  CL10 HCT 116 C226(0.74); C294(0.92); C384(1.04)  LDD0685  [35]
 LDCM0369  CL100 HCT 116 C294(0.82); C384(1.06); C226(1.08)  LDD0686  [35]
 LDCM0370  CL101 HCT 116 C294(0.93); C384(1.03); C226(1.13)  LDD0687  [35]
 LDCM0371  CL102 HCT 116 C384(0.92); C294(1.02); C226(1.18)  LDD0688  [35]
 LDCM0372  CL103 HCT 116 C294(0.94); C384(0.98); C226(1.25)  LDD0689  [35]
 LDCM0373  CL104 HCT 116 C384(0.96); C294(0.98); C226(1.03)  LDD0690  [35]
 LDCM0374  CL105 HCT 116 C294(1.02); C384(1.14); C226(1.17)  LDD0691  [35]
 LDCM0375  CL106 HCT 116 C294(0.94); C384(1.46); C226(1.60)  LDD0692  [35]
 LDCM0376  CL107 HCT 116 C294(1.08); C384(1.13); C226(1.22)  LDD0693  [35]
 LDCM0377  CL108 HCT 116 C294(1.17); C226(1.18); C384(1.32)  LDD0694  [35]
 LDCM0378  CL109 HCT 116 C294(0.98); C384(1.04); C226(1.11)  LDD0695  [35]
 LDCM0379  CL11 HCT 116 C226(0.83); C294(0.95); C384(1.08)  LDD0696  [35]
 LDCM0380  CL110 HCT 116 C294(1.12); C226(1.15); C384(1.26)  LDD0697  [35]
 LDCM0381  CL111 HCT 116 C226(0.88); C384(0.99); C294(1.06)  LDD0698  [35]
 LDCM0382  CL112 HCT 116 C294(0.81); C384(1.02); C226(1.05)  LDD0699  [35]
 LDCM0383  CL113 HCT 116 C294(0.73); C226(0.77); C384(0.91)  LDD0700  [35]
 LDCM0384  CL114 HCT 116 C226(0.72); C294(0.79); C384(0.81)  LDD0701  [35]
 LDCM0385  CL115 HCT 116 C226(0.76); C294(0.85); C384(0.94)  LDD0702  [35]
 LDCM0386  CL116 HCT 116 C226(0.66); C294(0.84); C384(1.10)  LDD0703  [35]
 LDCM0387  CL117 HCT 116 C384(1.18); C226(1.54)  LDD0704  [35]
 LDCM0388  CL118 HCT 116 C226(0.89); C384(0.98)  LDD0705  [35]
 LDCM0389  CL119 HCT 116 C226(0.80); C384(0.91)  LDD0706  [35]
 LDCM0390  CL12 HCT 116 C226(0.85); C384(1.06); C294(1.09)  LDD0707  [35]
 LDCM0391  CL120 HCT 116 C226(0.85); C384(0.97)  LDD0708  [35]
 LDCM0392  CL121 HCT 116 C226(0.68); C384(0.73); C294(0.80)  LDD0709  [35]
 LDCM0393  CL122 HCT 116 C226(0.74); C384(0.77); C294(0.91)  LDD0710  [35]
 LDCM0394  CL123 HCT 116 C226(0.58); C384(0.89); C294(0.94)  LDD0711  [35]
 LDCM0395  CL124 HCT 116 C226(0.65); C294(0.81); C384(0.85)  LDD0712  [35]
 LDCM0396  CL125 HCT 116 C226(0.98); C294(1.05); C384(1.56)  LDD0713  [35]
 LDCM0397  CL126 HCT 116 C294(1.03); C226(1.03); C384(1.04)  LDD0714  [35]
 LDCM0398  CL127 HCT 116 C294(0.87); C384(0.98); C226(1.06)  LDD0715  [35]
 LDCM0399  CL128 HCT 116 C294(0.92); C384(1.08); C226(1.26)  LDD0716  [35]
 LDCM0400  CL13 HCT 116 C226(0.77); C294(1.05); C384(1.07)  LDD0717  [35]
 LDCM0401  CL14 HCT 116 C226(0.77); C294(0.98); C384(1.00)  LDD0718  [35]
 LDCM0402  CL15 HCT 116 C226(0.75); C294(1.02); C384(1.20)  LDD0719  [35]
 LDCM0403  CL16 HCT 116 C384(0.74); C226(0.87)  LDD0720  [35]
 LDCM0404  CL17 HCT 116 C294(0.78); C226(0.78); C384(1.07)  LDD0721  [35]
 LDCM0405  CL18 HCT 116 C226(0.76); C294(0.76); C384(0.98)  LDD0722  [35]
 LDCM0406  CL19 HCT 116 C226(0.88); C294(0.88); C384(1.00)  LDD0723  [35]
 LDCM0407  CL2 HCT 116 C226(0.95); C294(1.03); C384(1.05)  LDD0724  [35]
 LDCM0408  CL20 HCT 116 C294(0.59); C384(0.80); C226(0.84)  LDD0725  [35]
 LDCM0409  CL21 HCT 116 C294(0.72); C226(0.83); C384(0.96)  LDD0726  [35]
 LDCM0410  CL22 HCT 116 C294(0.70); C226(0.85); C384(0.85)  LDD0727  [35]
 LDCM0411  CL23 HCT 116 C226(0.71); C294(0.82); C384(0.83)  LDD0728  [35]
 LDCM0412  CL24 HCT 116 C294(0.75); C226(0.80); C384(0.81)  LDD0729  [35]
 LDCM0413  CL25 HCT 116 C226(0.82); C294(1.10); C384(0.97)  LDD0730  [35]
 LDCM0414  CL26 HCT 116 C226(0.76); C294(0.90); C384(0.90)  LDD0731  [35]
 LDCM0415  CL27 HCT 116 C226(0.84); C294(0.86); C384(0.86)  LDD0732  [35]
 LDCM0416  CL28 HCT 116 C226(0.73); C294(0.77); C384(0.84)  LDD0733  [35]
 LDCM0417  CL29 HCT 116 C226(0.75); C294(0.64); C384(0.83)  LDD0734  [35]
 LDCM0418  CL3 HCT 116 C226(0.82); C294(0.84); C384(1.35)  LDD0735  [35]
 LDCM0419  CL30 HCT 116 C226(0.74); C294(1.16); C384(1.06)  LDD0736  [35]
 LDCM0420  CL31 HCT 116 C226(0.95); C294(0.83); C384(0.93)  LDD0737  [35]
 LDCM0421  CL32 HCT 116 C226(0.83); C294(0.85); C384(0.95)  LDD0738  [35]
 LDCM0422  CL33 HCT 116 C226(0.66); C294(0.77); C384(0.81)  LDD0739  [35]
 LDCM0423  CL34 HCT 116 C226(0.71); C294(0.86); C384(0.74)  LDD0740  [35]
 LDCM0424  CL35 HCT 116 C226(0.70); C294(0.84); C384(0.85)  LDD0741  [35]
 LDCM0425  CL36 HCT 116 C226(0.72); C294(0.87); C384(0.94)  LDD0742  [35]
 LDCM0426  CL37 HCT 116 C226(0.74); C294(0.84); C384(0.92)  LDD0743  [35]
 LDCM0428  CL39 HCT 116 C226(0.91); C294(0.88); C384(1.00)  LDD0745  [35]
 LDCM0429  CL4 HCT 116 C226(0.96); C294(0.92); C384(0.95)  LDD0746  [35]
 LDCM0430  CL40 HCT 116 C226(0.79); C294(0.79); C384(1.08)  LDD0747  [35]
 LDCM0431  CL41 HCT 116 C226(0.87); C294(0.88); C384(0.84)  LDD0748  [35]
 LDCM0432  CL42 HCT 116 C226(0.89); C294(1.03); C384(1.02)  LDD0749  [35]
 LDCM0433  CL43 HCT 116 C226(0.88); C294(1.05); C384(1.00)  LDD0750  [35]
 LDCM0434  CL44 HCT 116 C226(0.81); C294(0.82); C384(1.03)  LDD0751  [35]
 LDCM0435  CL45 HCT 116 C226(0.79); C294(0.82); C384(0.92)  LDD0752  [35]
 LDCM0436  CL46 HCT 116 C226(0.90); C294(0.86); C384(1.10)  LDD0753  [35]
 LDCM0437  CL47 HCT 116 C226(1.08); C294(0.86); C384(1.06)  LDD0754  [35]
 LDCM0438  CL48 HCT 116 C226(0.81); C294(1.01); C384(1.11)  LDD0755  [35]
 LDCM0439  CL49 HCT 116 C226(1.16); C294(1.01); C384(1.08)  LDD0756  [35]
 LDCM0440  CL5 HCT 116 C226(0.98); C294(1.14); C384(1.22)  LDD0757  [35]
 LDCM0441  CL50 HCT 116 C226(1.22); C294(1.19); C384(1.14)  LDD0758  [35]
 LDCM0442  CL51 HCT 116 C226(1.26); C294(1.36); C384(1.15)  LDD0759  [35]
 LDCM0443  CL52 HCT 116 C226(1.09); C294(0.96); C384(1.00)  LDD0760  [35]
 LDCM0444  CL53 HCT 116 C226(0.89); C294(0.88); C384(1.00)  LDD0761  [35]
 LDCM0445  CL54 HCT 116 C226(0.91); C294(0.83); C384(1.04)  LDD0762  [35]
 LDCM0446  CL55 HCT 116 C226(1.16); C294(0.87); C384(1.21)  LDD0763  [35]
 LDCM0447  CL56 HCT 116 C226(1.03); C294(0.80); C384(1.08)  LDD0764  [35]
 LDCM0448  CL57 HCT 116 C226(1.24); C294(0.92); C384(0.97)  LDD0765  [35]
 LDCM0449  CL58 HCT 116 C226(0.78); C294(0.81); C384(1.04)  LDD0766  [35]
 LDCM0450  CL59 HCT 116 C226(1.06); C294(0.92); C384(1.05)  LDD0767  [35]
 LDCM0451  CL6 HCT 116 C226(0.80); C294(0.90); C384(0.90)  LDD0768  [35]
 LDCM0452  CL60 HCT 116 C226(0.86); C294(0.77); C384(1.06)  LDD0769  [35]
 LDCM0453  CL61 HCT 116 C226(1.01); C294(0.93); C384(1.09)  LDD0770  [35]
 LDCM0454  CL62 HCT 116 C226(0.95); C294(0.93); C384(1.04)  LDD0771  [35]
 LDCM0455  CL63 HCT 116 C226(0.84); C294(0.88); C384(0.94)  LDD0772  [35]
 LDCM0456  CL64 HCT 116 C226(0.84); C294(0.89); C384(1.02)  LDD0773  [35]
 LDCM0457  CL65 HCT 116 C226(1.20); C294(0.99); C384(1.11)  LDD0774  [35]
 LDCM0458  CL66 HCT 116 C226(0.81); C294(1.02); C384(0.99)  LDD0775  [35]
 LDCM0459  CL67 HCT 116 C226(1.06); C294(0.90); C384(1.05)  LDD0776  [35]
 LDCM0460  CL68 HCT 116 C226(0.90); C294(0.93); C384(1.12)  LDD0777  [35]
 LDCM0461  CL69 HCT 116 C226(0.96); C294(0.92); C384(1.07)  LDD0778  [35]
 LDCM0462  CL7 HCT 116 C226(0.84); C294(1.04); C384(1.15)  LDD0779  [35]
 LDCM0463  CL70 HCT 116 C226(0.84); C294(0.79); C384(1.02)  LDD0780  [35]
 LDCM0464  CL71 HCT 116 C226(0.93); C294(0.93); C384(1.12)  LDD0781  [35]
 LDCM0465  CL72 HCT 116 C226(0.96); C294(0.94); C384(1.03)  LDD0782  [35]
 LDCM0466  CL73 HCT 116 C226(0.89); C294(0.97); C384(1.05)  LDD0783  [35]
 LDCM0467  CL74 HCT 116 C226(0.93); C294(0.89); C384(1.08)  LDD0784  [35]
 LDCM0469  CL76 HCT 116 C226(1.37); C294(0.84); C384(1.13)  LDD0786  [35]
 LDCM0470  CL77 HCT 116 C226(0.96); C294(1.01); C384(1.15)  LDD0787  [35]
 LDCM0471  CL78 HCT 116 C226(0.92); C294(0.88); C384(1.05)  LDD0788  [35]
 LDCM0472  CL79 HCT 116 C226(1.49); C294(0.82); C384(1.27)  LDD0789  [35]
 LDCM0473  CL8 HCT 116 C226(0.83); C294(0.91); C384(1.06)  LDD0790  [35]
 LDCM0474  CL80 HCT 116 C226(1.35); C294(0.85); C384(1.07)  LDD0791  [35]
 LDCM0475  CL81 HCT 116 C226(1.08); C294(0.91); C384(1.40)  LDD0792  [35]
 LDCM0476  CL82 HCT 116 C226(1.19); C294(0.91); C384(1.42)  LDD0793  [35]
 LDCM0477  CL83 HCT 116 C226(1.19); C294(0.86); C384(1.32)  LDD0794  [35]
 LDCM0478  CL84 HCT 116 C226(1.01); C294(0.92); C384(1.07)  LDD0795  [35]
 LDCM0479  CL85 HCT 116 C226(1.42); C294(0.76); C384(1.12)  LDD0796  [35]
 LDCM0480  CL86 HCT 116 C226(0.90); C294(0.86); C384(1.31)  LDD0797  [35]
 LDCM0481  CL87 HCT 116 C226(1.24); C294(0.81); C384(1.43)  LDD0798  [35]
 LDCM0482  CL88 HCT 116 C226(1.06); C294(0.86); C384(1.57)  LDD0799  [35]
 LDCM0483  CL89 HCT 116 C226(1.18); C294(0.94); C384(1.19)  LDD0800  [35]
 LDCM0484  CL9 HCT 116 C226(0.76); C294(0.91); C384(0.89)  LDD0801  [35]
 LDCM0485  CL90 HCT 116 C226(1.04); C294(1.01); C384(1.33)  LDD0802  [35]
 LDCM0486  CL91 HCT 116 C226(1.02); C294(1.04); C384(1.00)  LDD0803  [35]
 LDCM0487  CL92 HCT 116 C226(1.16); C294(1.12); C384(1.34)  LDD0804  [35]
 LDCM0488  CL93 HCT 116 C226(1.23); C294(1.10); C384(1.26)  LDD0805  [35]
 LDCM0489  CL94 HCT 116 C226(0.99); C294(0.90); C384(0.98)  LDD0806  [35]
 LDCM0490  CL95 HCT 116 C226(1.04); C294(0.86); C384(1.13)  LDD0807  [35]
 LDCM0491  CL96 HCT 116 C226(0.95); C294(0.94); C384(1.00)  LDD0808  [35]
 LDCM0492  CL97 HCT 116 C226(0.88); C294(0.93); C384(0.86)  LDD0809  [35]
 LDCM0493  CL98 HCT 116 C226(1.00); C294(0.79); C384(1.10)  LDD0810  [35]
 LDCM0494  CL99 HCT 116 C226(1.09); C294(0.88); C384(1.15)  LDD0811  [35]
 LDCM0634  CY-0357 Hep-G2 C384(2.78)  LDD2228  [20]
 LDCM0495  E2913 HEK-293T C384(1.04); C294(0.92)  LDD1698  [36]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C294(1.10)  LDD1702  [9]
 LDCM0625  F8 Ramos C384(1.01); C226(0.24)  LDD2187  [37]
 LDCM0572  Fragment10 Ramos C384(0.62); C226(0.65)  LDD2189  [37]
 LDCM0573  Fragment11 Ramos C384(0.52)  LDD2190  [37]
 LDCM0574  Fragment12 Ramos C384(0.84); C226(0.66)  LDD2191  [37]
 LDCM0575  Fragment13 Ramos C384(1.10); C226(0.96)  LDD2192  [37]
 LDCM0576  Fragment14 Ramos C384(0.88)  LDD2193  [37]
 LDCM0579  Fragment20 Ramos C384(0.55); C226(0.54)  LDD2194  [37]
 LDCM0580  Fragment21 Ramos C384(1.11); C226(1.01)  LDD2195  [37]
 LDCM0582  Fragment23 Ramos C384(0.71); C226(1.05)  LDD2196  [37]
 LDCM0578  Fragment27 Ramos C384(1.10); C226(1.18)  LDD2197  [37]
 LDCM0586  Fragment28 Ramos C384(0.95)  LDD2198  [37]
 LDCM0588  Fragment30 Ramos C384(1.07); C226(1.05)  LDD2199  [37]
 LDCM0589  Fragment31 Ramos C384(1.15); C226(1.39)  LDD2200  [37]
 LDCM0590  Fragment32 Ramos C384(0.55); C226(0.55)  LDD2201  [37]
 LDCM0468  Fragment33 HCT 116 C226(0.75); C294(0.92); C384(1.11)  LDD0785  [35]
 LDCM0596  Fragment38 Ramos C384(0.97); C226(0.61)  LDD2203  [37]
 LDCM0566  Fragment4 Ramos C384(0.81); C226(0.41)  LDD2184  [37]
 LDCM0427  Fragment51 HCT 116 C226(0.84); C294(0.90); C384(1.00)  LDD0744  [35]
 LDCM0610  Fragment52 Ramos C384(1.18); C226(1.21)  LDD2204  [37]
 LDCM0614  Fragment56 Ramos C384(1.39); C226(1.03)  LDD2205  [37]
 LDCM0569  Fragment7 Ramos C384(0.63); C226(0.22)  LDD2186  [37]
 LDCM0571  Fragment9 Ramos C384(0.94); C226(0.58)  LDD2188  [37]
 LDCM0116  HHS-0101 DM93 Y482(0.52); Y365(0.93)  LDD0264  [11]
 LDCM0117  HHS-0201 DM93 Y482(0.76); Y365(0.98)  LDD0265  [11]
 LDCM0118  HHS-0301 DM93 Y365(1.04); Y482(1.11)  LDD0266  [11]
 LDCM0119  HHS-0401 DM93 Y482(0.72); Y365(0.86)  LDD0267  [11]
 LDCM0120  HHS-0701 DM93 Y482(0.92); Y365(1.19)  LDD0268  [11]
 LDCM0107  IAA HeLa C226(0.00); H333(0.00); H483(0.00); C294(0.00)  LDD0221  [26]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [8]
 LDCM0022  KB02 HEK-293T C384(0.90); C226(0.98); C294(1.02)  LDD1492  [36]
 LDCM0023  KB03 Jurkat C384(7.38)  LDD0209  [10]
 LDCM0024  KB05 G361 C82(2.05); C384(3.03)  LDD3311  [38]
 LDCM0109  NEM HeLa C226(0.00); H483(0.00); H333(0.00); H390(0.00)  LDD0223  [26]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C384(1.04)  LDD2099  [9]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C384(0.94)  LDD2111  [9]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C384(0.40)  LDD2115  [9]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C384(1.80)  LDD2119  [9]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C384(0.80)  LDD2123  [9]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C384(0.78)  LDD2125  [9]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C384(0.71)  LDD2127  [9]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C384(0.88)  LDD2129  [9]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C384(0.63)  LDD2134  [9]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C384(1.08)  LDD2135  [9]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C384(0.85)  LDD2136  [9]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C384(0.83)  LDD2137  [9]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C384(0.84)  LDD2140  [9]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C384(2.92)  LDD2144  [9]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C384(0.61)  LDD2148  [9]
 LDCM0131  RA190 MM1.R C384(1.50); C294(1.08)  LDD0304  [39]
 LDCM0019  Staurosporine Hep-G2 2.00  LDD0083  [33]
 LDCM0021  THZ1 HCT 116 C226(1.03)  LDD2173  [35]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Arylsulfatase A (ARSA) Sulfatase family P15289
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Programmed cell death protein 6 (PDCD6) . O75340
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
NF-kappa-B inhibitor delta (NFKBID) NF-kappa-B inhibitor family Q8NI38
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin-associated protein 6-2 (KRTAP6-2) KRTAP type 6 family Q3LI66
Keratin-associated protein 13-2 (KRTAP13-2) PMG family Q52LG2
Centrosomal protein of 55 kDa (CEP55) . Q53EZ4
Protein TFG (TFG) . Q92734

References

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2 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
3 Design and synthesis of tailored human caseinolytic protease P inhibitors. Chem Commun (Camb). 2018 Aug 28;54(70):9833-9836. doi: 10.1039/c8cc05265d.
Mass spectrometry data entry: PXD010277
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
6 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
7 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
8 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
9 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
10 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
11 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
14 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
15 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
16 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
17 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
18 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
19 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
20 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
21 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
22 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
23 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
24 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
25 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
26 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
27 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
28 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
29 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
30 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
31 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
32 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
33 Comprehensive identification of staurosporine-binding kinases in the hepatocyte cell line HepG2 using Capture Compound Mass Spectrometry (CCMS). J Proteome Res. 2010 Feb 5;9(2):806-17. doi: 10.1021/pr9007333.
34 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
35 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
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Mass spectrometry data entry: PXD044402
37 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
38 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
39 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.