Details of the Competitor

General Information of Competitor

Competitor ID
LDCM0019
Competitor Name
Staurosporine
Synonyms
staurosporine; Staurosporin; 62996-74-1; (+)-Staurosporine; Antibiotic 230; Antibiotic AM 2282; AM-2282; CCRIS 3272; Antibiotic AM-2282; Alkaloid AM-2282 from Streptomyces; (5S,6R,7R,9R)-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,15,16-hexahydro-5H,14H-17-oxa-4b,9a,15-triaza-5,9-methanodibenzo[b,h]cyclonona[jkl]cyclopenta[e]-as-indacen-14-one; H88EPA0A3N; CHEMBL388978; CHEBI:15738; 8,12-Epoxy-1H,8H-2,7b,12a-triazadibenzo(a,g)cyclonona(cde)trinden-1-one, 2,3,9,10,11,12-hexahydro-9-methoxy-8-methyl-10-(methylamino)-, (8alpha,9beta,10beta,12alpha)-(+)-; (5S,6R,7R,9R)-6-methoxy-5-methyl-7-methylamino-6,7,8,9,15,16-hexahydro-5H,14H-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-14-one; UNII-H88EPA0A3N; GNF-PF-1389; methoxy-methyl-(methylamino)[?]one; SR-00000001485; DTXSID6041131; Staurosporin, 4; 1nvr; 1stc; 1xbc; 1xjd; 1yhs; 2gcd; Staurosporine, 8; C28H26N4O3; CGP 39360; Staurosporine & TNF; 1q3d; 1sm2; 2dq7; STAUROSPORINE [MI]; MolMap_000047; SCHEMBL8157; CBiol_001978; BSPBio_001146; GTPL346; BDBM2579; MEGxm0_000307; 1u59; BCPP000063; Bio1_000264; Bio1_000753; Bio1_001242; HMS1990J07; HMS3650B17; EX-A1777; AM2282; CGP-39360; HB0590; NSC755774; s1421; Staurosporin and Antibiotic AM-2282; AKOS015897119; AM 2282; CCG-208052; DB02010; NSC-755774; QTL1_000078; NCGC00162400-01; NCGC00162400-02; NCGC00162400-03; NCGC00162400-04; NCGC00162400-05; NCGC00162400-06; NCGC00162400-09; 9,13-Epoxy-1H,9H-diindolo(1,2,3-gh:3',2',1'-lm)pyrrolo(3,4-j)(1,7)-benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-11-(methylamino)-, (9S-(9alpha,10beta,11beta,13alpha)-; AC-35765; HY-15141; NS00011817; Staurosporine & Tumor necrosis factor (TNF); T4000; Q5957181; SR-00000001485-4; BRD-K17953061-001-02-8; BRD-K17953061-001-04-4; BRD-K17953061-001-05-1; BRD-K17953061-001-08-5; BRD-K17953061-001-10-1; BRD-K17953061-001-11-9; (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one; (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8,10,12,14(28),15(19),20(27),21,23,25-nonaen-16-one; (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-16-one; (5S,6R,7R,9R)-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,15,16-hexahydro-5H,14H-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-14-one; (9S,10R,11R,13R)- 2,3,10,11,12,13-HEXAHYDRO-10-METHOXY-9-METHYL-11-(METHYLAMINO)-9,13-EPOXY-1H,9H-DIINDOLO(1,2,3-GH:3',2',1'-LM)PYRROLO(3,4-J)(1,7)BENZODIAZONIN-1-ONE; 109189-95-9; 9,13-Epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-11-(methylamino)-, (9S,10R,11R,13R)- & Tumor necrosis factor (TNF); 9,13-Epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-11-(methylamino)-, (9S,10R,11R,13R)- (9CI); 9,13-Epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-11-(methylamino)-, [9S-(9alpha,10beta,11beta,13alpha)]-
Structure
3D MOL 2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 466.5
Lipid-water partition coefficient (xlogp) 3.2
Rotatable Bond Count (rotbonds) 2
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 4
Chemical Identifiers
Formula
C28H26N4O3
IUPAC Name
(2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-16-one
Canonical SMILES
CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)NC)OC
InChI
InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
InChIKey
HKSZLNNOFSGOKW-FYTWVXJKSA-N

The Competitor Interaction Atlas

Probe(s) Related This Competitor

PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Competitor
Probe Name Structure Concentration Cell-system Ref
Staurosporine capture compound
 Probe Info  		50 uM Human hepatoblastoma cell lysate (Hep-G2) [1]

Target(s) List of this Competitor

77 Enzyme Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial (DECR1) LDTP06612 .  LDD0083 
26S proteasome non-ATPase regulatory subunit 3 (PSMD3) LDTP00714 2.00  LDD0083 
3-phosphoinositide-dependent protein kinase 1 (PDPK1) LDTP00670 .  LDD0083 
Adenosine 5'-monophosphoramidase HINT1 (HINT1) LDTP04306 2.50  LDD0083 
ADP-ribosylation factor 4 (ARF4) LDTP02942 2.25  LDD0083 
ATP-citrate synthase (ACLY) LDTP04561 2.17  LDD0083 
ATP-dependent RNA helicase DDX54 (DDX54) LDTP09428 .  LDD0083 
Aurora kinase A (AURKA) LDTP00491 10.00  LDD0083 
Aurora kinase B (AURKB) LDTP10346 .  LDD0083 
CAAX prenyl protease 1 homolog (ZMPSTE24) LDTP01328 .  LDD0083 
Cyclin-dependent kinase 2 (CDK2) LDTP03299 .  LDD0083 
Cyclin-dependent kinase 5 (CDK5) LDTP05245 .  LDD0083 
Cytochrome b5 type B (CYB5B) LDTP00697 .  LDD0083 
Cytosolic non-specific dipeptidase (CNDP2) LDTP10514 2.00  LDD0083 
Delta(14)-sterol reductase LBR (LBR) LDTP06200 2.00  LDD0083 
DNA replication licensing factor MCM7 (MCM7) LDTP03682 .  LDD0083 
Eukaryotic translation initiation factor 3 subunit F (EIF3F) LDTP00246 .  LDD0083 
Focal adhesion kinase 1 (PTK2) LDTP05453 .  LDD0083 
Fructose-bisphosphate aldolase A (ALDOA) LDTP02008 2.00  LDD0083 
Glucose-6-phosphate 1-dehydrogenase (G6PD) LDTP02569 .  LDD0083 
Glutaminyl-peptide cyclotransferase-like protein (QPCTL) LDTP12790 .  LDD0083 
Glutathione S-transferase omega-1 (GSTO1) LDTP05128 .  LDD0083 
Glycerol-3-phosphate phosphatase (PGP) LDTP00089 .  LDD0083 
Glycogen synthase kinase-3 beta (GSK3B) LDTP04319 .  LDD0083 
Histamine N-methyltransferase (HNMT) LDTP04341 .  LDD0083 
Kinesin heavy chain isoform 5A (KIF5A) LDTP05665 2.00  LDD0083 
MAP/microtubule affinity-regulating kinase 3 (MARK3) LDTP03388 .  LDD0083 
Methylsterol monooxygenase 1 (MSMO1) LDTP06477 2.00  LDD0083 
Minor histocompatibility antigen H13 (HM13) LDTP09396 3.00  LDD0083 
Misshapen-like kinase 1 (MINK1) LDTP08863 .  LDD0083 
NAD(P)H dehydrogenase [quinone] 1 (NQO1) LDTP02798 12.00  LDD0083 
Nicotinamide phosphoribosyltransferase (NAMPT) LDTP04051 3.50  LDD0083 
Obg-like ATPase 1 (OLA1) LDTP12610 .  LDD0083 
Peroxiredoxin-4 (PRDX4) LDTP05773 .  LDD0083 
Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1) LDTP06307 2.40  LDD0083 
Peroxisomal trans-2-enoyl-CoA reductase (PECR) LDTP11437 17.00  LDD0083 
Phosphoglycerate mutase 1 (PGAM1) LDTP02963 2.00  LDD0083 
Poly [ADP-ribose] polymerase 1 (PARP1) LDTP02375 .  LDD0083 
Probable ubiquitin carboxyl-terminal hydrolase FAF-X (USP9X) LDTP09961 2.00  LDD0083 
Prostaglandin E synthase 3 (PTGES3) LDTP06338 .  LDD0083 
Prostaglandin reductase 1 (PTGR1) LDTP06227 .  LDD0083 
Protein disulfide-isomerase A4 (PDIA4) LDTP02677 2.44  LDD0083 
Protein NDRG1 (NDRG1) LDTP09810 2.00  LDD0083 
Proto-oncogene tyrosine-protein kinase Src (SRC) LDTP02638 23.50  LDD0083 
Puromycin-sensitive aminopeptidase (NPEPPS) LDTP04712 .  LDD0083 
Pyridoxal kinase (PDXK) LDTP00343 .  LDD0083 
Ras-related protein Rab-1A (RAB1A) LDTP05006 2.14  LDD0083 
Regulator of telomere elongation helicase 1 (RTEL1) LDTP12878 .  LDD0083 
Replication factor C subunit 4 (RFC4) LDTP03725 2.50  LDD0083 
Rho-associated protein kinase 2 (ROCK2) LDTP01127 .  LDD0083 
Ribose-phosphate pyrophosphokinase 1 (PRPS1) LDTP04882 .  LDD0083 
Ribosyldihydronicotinamide dehydrogenase [quinone] (NQO2) LDTP02824 23.00  LDD0083 
Serine/threonine-protein kinase 24 (STK24) LDTP14240 4.00  LDD0083 
Serine/threonine-protein kinase 26 (STK26) LDTP13031 .  LDD0083 
Serine/threonine-protein kinase 3 (STK3) LDTP05779 .  LDD0083 
Serine/threonine-protein kinase greatwall (MASTL) LDTP10367 .  LDD0083 
Serine/threonine-protein kinase MARK1 (MARK1) LDTP12968 .  LDD0083 
Serine/threonine-protein kinase MARK2 (MARK2) LDTP07930 .  LDD0083 
Serine/threonine-protein kinase N1 (PKN1) LDTP06535 .  LDD0083 
Serine/threonine-protein kinase N2 (PKN2) LDTP06536 .  LDD0083 
Serine/threonine-protein kinase PAK 4 (PAK4) LDTP01751 .  LDD0083 
Serine/threonine-protein kinase RIO2 (RIOK2) LDTP11299 .  LDD0083 
Serine/threonine-protein kinase TBK1 (TBK1) LDTP13270 .  LDD0083 
Serine/threonine-protein kinase ULK3 (ULK3) LDTP07577 .  LDD0083 
Spliceosome RNA helicase DDX39B (DDX39B) LDTP05991 .  LDD0083 
Staphylococcal nuclease domain-containing protein 1 (SND1) LDTP07929 .  LDD0083 
STE20/SPS1-related proline-alanine-rich protein kinase (STK39) LDTP13203 .  LDD0083 
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (NSDHL) LDTP06455 2.00  LDD0083 
Tyrosine-protein kinase CSK (CSK) LDTP03944 .  LDD0083 
Tyrosine-protein kinase Fer (FER) LDTP02859 .  LDD0083 
Tyrosine-protein kinase Yes (YES1) LDTP02231 .  LDD0083 
Ubiquitin thioesterase OTUB1 (OTUB1) LDTP10318 4.00  LDD0083 
Ubiquitin-like modifier-activating enzyme 5 (UBA5) LDTP11675 .  LDD0083 
UDP-glucose 6-dehydrogenase (UGDH) LDTP01033 3.33  LDD0083 
Unconventional myosin-Va (MYO5A) LDTP14061 .  LDD0083 
Unconventional myosin-VI (MYO6) LDTP13609 .  LDD0083 
Vesicle-fusing ATPase (NSF) LDTP04096 .  LDD0083 
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⏷ Show the Full List of 77 Enzyme
24 Transporter and channel Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
Annexin A11 (ANXA11) LDTP04393 2.00  LDD0083 
Apolipoprotein E (APOE) LDTP01936 .  LDD0083 
ATP synthase-coupling factor 6, mitochondrial (ATP5PF) LDTP02972 .  LDD0083 
ATP-binding cassette sub-family F member 1 (ABCF1) LDTP09149 .  LDD0083 
B-cell receptor-associated protein 31 (BCAP31) LDTP04426 2.00  LDD0083 
Copine-1 (CPNE1) LDTP10989 2.00  LDD0083 
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 (DAD1) LDTP04938 .  LDD0083 
Exportin-1 (XPO1) LDTP00501 2.67  LDD0083 
Extended synaptotagmin-2 (ESYT2) LDTP00014 .  LDD0083 
Filamin-A (FLNA) LDTP03107 2.00  LDD0083 
Filamin-B (FLNB) LDTP01197 2.00  LDD0083 
G2/mitotic-specific cyclin-B1 (CCNB1) LDTP02735 .  LDD0083 
Hypoxia up-regulated protein 1 (HYOU1) LDTP14066 .  LDD0083 
Importin-4 (IPO4) LDTP09515 .  LDD0083 
Large neutral amino acids transporter small subunit 1 (SLC7A5) LDTP05305 .  LDD0083 
Mitochondrial carrier homolog 2 (MTCH2) LDTP14235 .  LDD0083 
Mitochondrial import inner membrane translocase subunit TIM44 (TIMM44) LDTP00821 5.67  LDD0083 
Nuclear pore complex protein Nup93 (NUP93) LDTP08769 .  LDD0083 
Potassium voltage-gated channel subfamily H member 7 (KCNH7) LDTP12559 .  LDD0083 
Protein ERGIC-53 (LMAN1) LDTP04237 4.00  LDD0083 
Protein SEC13 homolog (SEC13) LDTP04707 .  LDD0083 
Solute carrier family 66 member 2 (SLC66A2) LDTP08807 .  LDD0083 
Transmembrane emp24 domain-containing protein 2 (TMED2) LDTP06365 2.00  LDD0083 
Vesicle-associated membrane protein 2 (VAMP2) LDTP05039 .  LDD0083 
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⏷ Show the Full List of 24 Transporter and channel
2 Transcription factor Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
Homeobox and leucine zipper protein Homez (HOMEZ) LDTP08584 .  LDD0083 
Signal transducer and activator of transcription 3 (STAT3) LDTP03903 .  LDD0083 
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1 Immunoglobulin Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
Myopalladin (MYPN) LDTP08193 .  LDD0083 
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28 Other Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
Actin-related protein 2 (ACTR2) LDTP04903 .  LDD0083 
Actin-related protein 3 (ACTR3) LDTP04902 .  LDD0083 
Cilia- and flagella-associated protein 44 (CFAP44) LDTP10597 .  LDD0083 
Coatomer subunit gamma-1 (COPG1) LDTP14216 5.00  LDD0083 
COX assembly mitochondrial protein 2 homolog (CMC2) LDTP18462 2.00  LDD0083 
Cysteine and glycine-rich protein 2 (CSRP2) LDTP06542 .  LDD0083 
Elongation factor 1-beta (EEF1B2) LDTP03283 .  LDD0083 
Elongation factor 1-delta (EEF1D) LDTP03499 .  LDD0083 
Emerin (EMD) LDTP04356 .  LDD0083 
Eukaryotic translation initiation factor 3 subunit B (EIF3B) LDTP04718 .  LDD0083 
La-related protein 1 (LARP1) LDTP07605 .  LDD0083 
Phosphatidylethanolamine-binding protein 1 (PEBP1) LDTP03520 3.00  LDD0083 
Plakophilin-2 (PKP2) LDTP11018 .  LDD0083 
Proteasome activator complex subunit 1 (PSME1) LDTP05484 3.17  LDD0083 
Receptor expression-enhancing protein 5 (REEP5) LDTP05257 2.00  LDD0083 
Retinitis pigmentosa 9 protein (RP9) LDTP09287 .  LDD0083 
RNA-binding protein 25 (RBM25) LDTP04294 2.25  LDD0083 
Serine/arginine-rich splicing factor 2 (SRSF2) LDTP05280 3.00  LDD0083 
Serine/arginine-rich splicing factor 6 (SRSF6) LDTP05802 .  LDD0083 
SHC-transforming protein 1 (SHC1) LDTP03479 .  LDD0083 
Sideroflexin-3 (SFXN3) LDTP11331 .  LDD0083 
Splicing factor 3A subunit 3 (SF3A3) LDTP05677 .  LDD0083 
Splicing factor 3B subunit 1 (SF3B1) LDTP01251 .  LDD0083 
Structural maintenance of chromosomes protein 4 (SMC4) LDTP12606 .  LDD0083 
Testin (TES) LDTP13227 2.00  LDD0083 
TRAF family member-associated NF-kappa-B activator (TANK) LDTP09901 .  LDD0083 
Tumor protein D52 (TPD52) LDTP04703 .  LDD0083 
Visinin-like protein 1 (VSNL1) LDTP05003 2.17  LDD0083 
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⏷ Show the Full List of 28 Other

Full Information of The Labelling Profiles of This Competitor

Staurosporine capture compound
 Probe Info 
Quantification: Probe vs (Probe+Competitor)
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration 50 uM
Quantitative Method LFQ
Competitor Name Staurosporine
Competitor Concentration 1 mM
In Vitro Experiment Model Model Type
Cell lysate
Derived Tissue
Liver
Disease Model Hepatoblastoma [ICD-11:DB91]
Model Name Human hepatoblastoma cell lysate (Hep-G2)
Interaction Atlas ID  LDD0083  Download The Altas

References

1 Comprehensive identification of staurosporine-binding kinases in the hepatocyte cell line HepG2 using Capture Compound Mass Spectrometry (CCMS). J Proteome Res. 2010 Feb 5;9(2):806-17. doi: 10.1021/pr9007333.