Details of the Target

General Information of Target

Target ID LDTP09428
Target Name ATP-dependent RNA helicase DDX54 (DDX54)
Gene Name DDX54
Gene ID 79039
Synonyms
ATP-dependent RNA helicase DDX54; EC 3.6.4.13; ATP-dependent RNA helicase DP97; DEAD box RNA helicase 97 kDa; DEAD box protein 54
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAADKGPAAGPRSRAAMAQWRKKKGLRKRRGAASQARGSDSEDGEFEIQAEDDARARKLG
PGRPLPTFPTSECTSDVEPDTREMVRAQNKKKKKSGGFQSMGLSYPVFKGIMKKGYKVPT
PIQRKTIPVILDGKDVVAMARTGSGKTACFLLPMFERLKTHSAQTGARALILSPTRELAL
QTLKFTKELGKFTGLKTALILGGDRMEDQFAALHENPDIIIATPGRLVHVAVEMSLKLQS
VEYVVFDEADRLFEMGFAEQLQEIIARLPGGHQTVLFSATLPKLLVEFARAGLTEPVLIR
LDVDTKLNEQLKTSFFLVREDTKAAVLLHLLHNVVRPQDQTVVFVATKHHAEYLTELLTT
QRVSCAHIYSALDPTARKINLAKFTLGKCSTLIVTDLAARGLDIPLLDNVINYSFPAKGK
LFLHRVGRVARAGRSGTAYSLVAPDEIPYLLDLHLFLGRSLTLARPLKEPSGVAGVDGML
GRVPQSVVDEEDSGLQSTLEASLELRGLARVADNAQQQYVRSRPAPSPESIKRAKEMDLV
GLGLHPLFSSRFEEEELQRLRLVDSIKNYRSRATIFEINASSRDLCSQVMRAKRQKDRKA
IARFQQGQQGRQEQQEGPVGPAPSRPALQEKQPEKEEEEEAGESVEDIFSEVVGRKRQRS
GPNRGAKRRREEARQRDQEFYIPYRPKDFDSERGLSISGEGGAFEQQAAGAVLDLMGDEA
QNLTRGRQQLKWDRKKKRFVGQSGQEDKKKIKTESGRYISSSYKRDLYQKWKQKQKIDDR
DSDEEGASDRRGPERRGGKRDRGQGASRPHAPGTPAGRVRPELKTKQQILKQRRRAQKLH
FLQRGGLKQLSARNRRRVQELQQGAFGRGARSKKGKMRKRM
Target Bioclass
Enzyme
Family
DEAD box helicase family, DDX54/DBP10 subfamily
Subcellular location
Nucleus, nucleolus
Function Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors.
Uniprot ID
Q8TDD1
Ensemble ID
ENST00000306014.10
HGNC ID
HGNC:20084

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
LN18 SNV: p.V129A DBIA    Probe Info 
MEWO SNV: p.F384I DBIA    Probe Info 
REH SNV: p.S565N DBIA    Probe Info 
SKMEL24 SNV: p.E215D DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 27 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K838(5.00)  LDD0277  [2]
Probe 1
 Probe Info  		Y758(21.41); Y763(12.36); Y768(8.23)  LDD3495  [3]
BTD
 Probe Info  		C365(1.17)  LDD2092  [4]
AHL-Pu-1
 Probe Info  		C73(2.51)  LDD0169  [5]
DBIA
 Probe Info  		C149(17.77)  LDD0205  [6]
ATP probe
 Probe Info  		K125(0.00); K687(0.00); K146(0.00)  LDD0199  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C389(0.00); C149(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		C365(0.00); C149(0.00); C73(0.00)  LDD0032  [9]
Lodoacetamide azide
 Probe Info  		C389(0.00); C149(0.00); C365(0.00); C586(0.00)  LDD0037  [8]
NAIA_4
 Probe Info  		C73(0.00); C365(0.00)  LDD2226  [10]
TFBX
 Probe Info  		N.A.  LDD0027  [11]
1d-yne
 Probe Info  		N.A.  LDD0356  [12]
Compound 10
 Probe Info  		N.A.  LDD2216  [13]
ENE
 Probe Info  		N.A.  LDD0006  [14]
IPM
 Probe Info  		C586(0.00); C73(0.00)  LDD0005  [14]
SF
 Probe Info  		N.A.  LDD0028  [15]
VSF
 Probe Info  		N.A.  LDD0007  [14]
YN-1
 Probe Info  		N.A.  LDD0446  [16]
Phosphinate-6
 Probe Info  		C586(0.00); C73(0.00)  LDD0018  [17]
1c-yne
 Probe Info  		N.A.  LDD0228  [12]
Acrolein
 Probe Info  		N.A.  LDD0217  [18]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [18]
Methacrolein
 Probe Info  		C73(0.00); C586(0.00)  LDD0218  [18]
W1
 Probe Info  		N.A.  LDD0236  [19]
AOyne
 Probe Info  		12.30  LDD0443  [20]
NAIA_5
 Probe Info  		C389(0.00); C149(0.00); C365(0.00)  LDD2223  [10]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		20.00  LDD0475  [21]
FFF probe3
 Probe Info  		13.37  LDD0464  [21]
VE-P
 Probe Info  		N.A.  LDD0396  [22]
Staurosporine capture compound
 Probe Info  		N.A.  LDD0083  [23]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C365(0.64); C586(1.43)  LDD2142  [4]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C365(0.90); C586(1.07)  LDD2112  [4]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C365(0.88)  LDD2130  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C365(1.32)  LDD2152  [4]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C365(0.72)  LDD2132  [4]
 LDCM0025  4SU-RNA DM93 C586(2.16)  LDD0170  [5]
 LDCM0026  4SU-RNA+native RNA HEK-293T C73(2.51)  LDD0169  [5]
 LDCM0214  AC1 HEK-293T C586(0.99); C365(0.98); C149(0.84); C73(1.00)  LDD1507  [24]
 LDCM0215  AC10 HEK-293T C586(0.96); C365(1.00); C149(1.14); C73(1.03)  LDD1508  [24]
 LDCM0226  AC11 HEK-293T C586(0.99); C365(0.89); C149(1.03); C73(0.95)  LDD1509  [24]
 LDCM0237  AC12 HEK-293T C586(1.04); C365(0.87); C149(0.97); C73(0.92)  LDD1510  [24]
 LDCM0259  AC14 HEK-293T C586(0.94); C365(1.01); C149(1.17); C73(0.97)  LDD1512  [24]
 LDCM0270  AC15 HEK-293T C586(0.98); C365(0.96); C149(0.99); C73(0.93)  LDD1513  [24]
 LDCM0276  AC17 HEK-293T C586(1.04); C365(0.95); C149(0.83); C73(1.02)  LDD1515  [24]
 LDCM0277  AC18 HEK-293T C586(0.96); C365(0.97); C149(1.00); C73(1.03)  LDD1516  [24]
 LDCM0278  AC19 HEK-293T C586(1.10); C365(0.89); C149(0.95); C73(1.05)  LDD1517  [24]
 LDCM0279  AC2 HEK-293T C586(0.89); C365(1.10); C149(0.90); C73(1.13)  LDD1518  [24]
 LDCM0280  AC20 HEK-293T C586(0.98); C365(0.95); C149(0.94); C73(1.02)  LDD1519  [24]
 LDCM0281  AC21 HEK-293T C586(0.99); C365(0.86); C149(0.99); C73(1.01)  LDD1520  [24]
 LDCM0282  AC22 HEK-293T C586(0.97); C365(1.09); C149(1.15); C73(0.93)  LDD1521  [24]
 LDCM0283  AC23 HEK-293T C586(1.06); C365(0.96); C149(1.06); C73(0.98)  LDD1522  [24]
 LDCM0284  AC24 HEK-293T C586(0.98); C365(1.04); C149(1.05); C73(0.96)  LDD1523  [24]
 LDCM0285  AC25 HEK-293T C586(1.05); C365(0.98); C149(1.37); C73(1.00)  LDD1524  [24]
 LDCM0286  AC26 HEK-293T C586(0.96); C365(0.97); C149(1.01); C73(0.94)  LDD1525  [24]
 LDCM0287  AC27 HEK-293T C586(0.99); C365(1.12); C149(1.22); C73(1.00)  LDD1526  [24]
 LDCM0288  AC28 HEK-293T C586(0.99); C365(1.02); C149(0.99); C73(0.95)  LDD1527  [24]
 LDCM0289  AC29 HEK-293T C586(1.00); C365(0.97); C149(0.84); C73(1.02)  LDD1528  [24]
 LDCM0290  AC3 HEK-293T C586(0.99); C365(1.08); C149(0.92); C73(1.03)  LDD1529  [24]
 LDCM0291  AC30 HEK-293T C586(0.98); C365(1.06); C149(1.10); C73(0.99)  LDD1530  [24]
 LDCM0292  AC31 HEK-293T C586(1.02); C365(0.79); C149(1.12); C73(0.95)  LDD1531  [24]
 LDCM0293  AC32 HEK-293T C586(0.98); C365(1.09); C149(1.36); C73(0.97)  LDD1532  [24]
 LDCM0294  AC33 HEK-293T C586(0.98); C365(1.04); C149(0.93); C73(0.92)  LDD1533  [24]
 LDCM0295  AC34 HEK-293T C586(1.00); C365(0.99); C149(1.02); C73(1.07)  LDD1534  [24]
 LDCM0296  AC35 HEK-293T C586(1.02); C365(0.92); C149(0.99); C73(1.04)  LDD1535  [24]
 LDCM0297  AC36 HEK-293T C586(0.99); C365(1.04); C149(1.10); C73(1.02)  LDD1536  [24]
 LDCM0298  AC37 HEK-293T C586(0.93); C365(0.99); C149(1.01); C73(1.05)  LDD1537  [24]
 LDCM0299  AC38 HEK-293T C586(0.92); C365(1.10); C149(1.00); C73(1.02)  LDD1538  [24]
 LDCM0300  AC39 HEK-293T C586(0.93); C365(0.88); C149(1.01); C73(0.99)  LDD1539  [24]
 LDCM0301  AC4 HEK-293T C586(1.00); C365(1.09); C149(1.07); C73(1.06)  LDD1540  [24]
 LDCM0302  AC40 HEK-293T C586(0.94); C365(0.97); C149(1.14); C73(1.00)  LDD1541  [24]
 LDCM0303  AC41 HEK-293T C586(1.01); C365(0.85); C149(0.98); C73(1.25)  LDD1542  [24]
 LDCM0304  AC42 HEK-293T C586(0.98); C365(1.09); C149(0.95); C73(1.17)  LDD1543  [24]
 LDCM0305  AC43 HEK-293T C586(1.01); C365(1.11); C149(1.04); C73(1.01)  LDD1544  [24]
 LDCM0306  AC44 HEK-293T C586(0.98); C365(0.99); C149(1.10); C73(1.03)  LDD1545  [24]
 LDCM0307  AC45 HEK-293T C586(0.98); C365(0.93); C149(1.28); C73(0.99)  LDD1546  [24]
 LDCM0308  AC46 HEK-293T C586(0.92); C365(1.12); C149(1.18); C73(0.90)  LDD1547  [24]
 LDCM0309  AC47 HEK-293T C586(0.93); C365(0.81); C149(0.93); C73(0.95)  LDD1548  [24]
 LDCM0310  AC48 HEK-293T C586(0.97); C365(1.03); C149(1.15); C73(1.09)  LDD1549  [24]
 LDCM0311  AC49 HEK-293T C586(0.96); C365(0.94); C149(1.01); C73(1.06)  LDD1550  [24]
 LDCM0312  AC5 HEK-293T C586(0.99); C365(1.06); C149(1.39); C73(1.01)  LDD1551  [24]
 LDCM0313  AC50 HEK-293T C586(0.91); C365(1.00); C149(1.06); C73(1.01)  LDD1552  [24]
 LDCM0314  AC51 HEK-293T C586(0.98); C365(1.09); C149(1.03); C73(1.02)  LDD1553  [24]
 LDCM0315  AC52 HEK-293T C586(0.95); C365(0.92); C149(0.91); C73(0.85)  LDD1554  [24]
 LDCM0316  AC53 HEK-293T C586(0.99); C365(1.04); C149(1.06); C73(0.96)  LDD1555  [24]
 LDCM0317  AC54 HEK-293T C586(0.93); C365(1.03); C149(1.10); C73(0.96)  LDD1556  [24]
 LDCM0318  AC55 HEK-293T C586(0.91); C365(0.88); C149(1.04); C73(0.92)  LDD1557  [24]
 LDCM0319  AC56 HEK-293T C586(0.96); C365(1.03); C149(1.00); C73(0.97)  LDD1558  [24]
 LDCM0320  AC57 HEK-293T C586(1.00); C365(0.91); C149(0.85); C73(1.09)  LDD1559  [24]
 LDCM0321  AC58 HEK-293T C586(0.98); C365(0.96); C149(0.97); C73(1.01)  LDD1560  [24]
 LDCM0322  AC59 HEK-293T C586(0.97); C365(1.06); C149(0.94); C73(0.96)  LDD1561  [24]
 LDCM0323  AC6 HEK-293T C586(0.98); C365(1.01); C149(1.32); C73(1.05)  LDD1562  [24]
 LDCM0324  AC60 HEK-293T C586(0.96); C365(1.01); C149(0.96); C73(0.97)  LDD1563  [24]
 LDCM0325  AC61 HEK-293T C586(0.98); C365(0.97); C149(1.00); C73(1.11)  LDD1564  [24]
 LDCM0326  AC62 HEK-293T C586(0.95); C365(1.01); C149(0.92); C73(1.05)  LDD1565  [24]
 LDCM0327  AC63 HEK-293T C586(0.96); C365(1.14); C149(0.98); C73(0.95)  LDD1566  [24]
 LDCM0328  AC64 HEK-293T C586(0.95); C365(1.08); C149(1.23); C73(1.04)  LDD1567  [24]
 LDCM0334  AC7 HEK-293T C586(0.97); C365(1.18); C149(1.07); C73(1.01)  LDD1568  [24]
 LDCM0345  AC8 HEK-293T C586(1.00); C365(1.04); C149(1.10); C73(1.05)  LDD1569  [24]
 LDCM0248  AKOS034007472 HEK-293T C586(1.03); C365(0.93); C149(1.11); C73(1.06)  LDD1511  [24]
 LDCM0356  AKOS034007680 HEK-293T C586(0.99); C365(1.01); C149(1.21); C73(1.06)  LDD1570  [24]
 LDCM0275  AKOS034007705 HEK-293T C586(1.01); C365(0.98); C149(1.07); C73(1.12)  LDD1514  [24]
 LDCM0103  BDHI 10 Jurkat C149(17.77)  LDD0205  [6]
 LDCM0630  CCW28-3 231MFP C73(1.32)  LDD2214  [25]
 LDCM0108  Chloroacetamide HeLa C73(0.00); C586(0.00)  LDD0222  [18]
 LDCM0632  CL-Sc Hep-G2 C149(20.00)  LDD2227  [10]
 LDCM0367  CL1 HEK-293T C586(0.88); C365(0.99); C149(0.78); C73(0.81)  LDD1571  [24]
 LDCM0368  CL10 HEK-293T C586(1.11); C365(1.02); C149(0.72); C73(0.87)  LDD1572  [24]
 LDCM0369  CL100 HEK-293T C586(1.02); C365(1.04); C149(1.07); C73(0.90)  LDD1573  [24]
 LDCM0370  CL101 HEK-293T C586(1.05); C365(0.92); C149(0.86); C73(0.96)  LDD1574  [24]
 LDCM0371  CL102 HEK-293T C586(0.96); C365(1.03); C149(1.19); C73(0.86)  LDD1575  [24]
 LDCM0372  CL103 HEK-293T C586(1.04); C365(0.87); C149(0.99); C73(0.82)  LDD1576  [24]
 LDCM0373  CL104 HEK-293T C586(1.02); C365(1.06); C149(1.34); C73(0.89)  LDD1577  [24]
 LDCM0374  CL105 HEK-293T C586(0.86); C365(1.13); C149(0.92); C73(1.05)  LDD1578  [24]
 LDCM0375  CL106 HEK-293T C586(0.92); C365(1.24); C149(1.21); C73(0.98)  LDD1579  [24]
 LDCM0376  CL107 HEK-293T C586(1.01); C365(0.95); C149(1.03); C73(0.94)  LDD1580  [24]
 LDCM0377  CL108 HEK-293T C586(0.96); C365(0.94); C149(1.60); C73(0.93)  LDD1581  [24]
 LDCM0378  CL109 HEK-293T C586(0.88); C365(1.02); C149(0.98); C73(1.02)  LDD1582  [24]
 LDCM0379  CL11 HEK-293T C586(0.96); C365(0.78); C149(0.88); C73(1.01)  LDD1583  [24]
 LDCM0380  CL110 HEK-293T C586(1.01); C365(1.02); C149(1.20); C73(0.86)  LDD1584  [24]
 LDCM0381  CL111 HEK-293T C586(1.05); C365(0.84); C149(1.01); C73(0.97)  LDD1585  [24]
 LDCM0382  CL112 HEK-293T C586(0.99); C365(0.98); C149(1.53); C73(1.02)  LDD1586  [24]
 LDCM0383  CL113 HEK-293T C586(0.94); C365(1.06); C149(0.86); C73(0.94)  LDD1587  [24]
 LDCM0384  CL114 HEK-293T C586(0.98); C365(1.31); C149(1.09); C73(0.88)  LDD1588  [24]
 LDCM0385  CL115 HEK-293T C586(0.98); C365(0.97); C149(1.05); C73(0.92)  LDD1589  [24]
 LDCM0386  CL116 HEK-293T C586(0.93); C365(1.20); C149(1.13); C73(1.01)  LDD1590  [24]
 LDCM0387  CL117 HEK-293T C586(0.93); C365(0.96); C149(1.05); C73(1.24)  LDD1591  [24]
 LDCM0388  CL118 HEK-293T C586(0.94); C365(0.95); C149(1.19); C73(1.05)  LDD1592  [24]
 LDCM0389  CL119 HEK-293T C586(0.95); C365(0.90); C149(1.10); C73(0.97)  LDD1593  [24]
 LDCM0390  CL12 HEK-293T C586(0.99); C365(0.97); C149(1.00); C73(0.95)  LDD1594  [24]
 LDCM0391  CL120 HEK-293T C586(1.03); C365(0.99); C149(1.17); C73(0.98)  LDD1595  [24]
 LDCM0392  CL121 HEK-293T C586(0.93); C365(1.17); C149(0.93); C73(1.12)  LDD1596  [24]
 LDCM0393  CL122 HEK-293T C586(0.98); C365(0.82); C149(1.11); C73(1.00)  LDD1597  [24]
 LDCM0394  CL123 HEK-293T C586(0.89); C365(0.87); C149(0.82); C73(0.91)  LDD1598  [24]
 LDCM0395  CL124 HEK-293T C586(0.99); C365(0.91); C149(1.08); C73(0.92)  LDD1599  [24]
 LDCM0396  CL125 HEK-293T C586(0.92); C365(1.00); C149(0.96); C73(0.89)  LDD1600  [24]
 LDCM0397  CL126 HEK-293T C586(1.02); C365(1.07); C149(1.18); C73(0.89)  LDD1601  [24]
 LDCM0398  CL127 HEK-293T C586(0.98); C365(0.90); C149(1.25); C73(0.83)  LDD1602  [24]
 LDCM0399  CL128 HEK-293T C586(0.96); C365(1.10); C149(1.12); C73(0.94)  LDD1603  [24]
 LDCM0400  CL13 HEK-293T C586(0.95); C365(0.92); C149(0.90); C73(0.88)  LDD1604  [24]
 LDCM0401  CL14 HEK-293T C586(0.93); C365(1.01); C149(1.06); C73(0.86)  LDD1605  [24]
 LDCM0402  CL15 HEK-293T C586(0.88); C365(0.83); C149(1.07); C73(0.85)  LDD1606  [24]
 LDCM0403  CL16 HEK-293T C586(1.02); C365(1.01); C149(1.32); C73(0.92)  LDD1607  [24]
 LDCM0404  CL17 HEK-293T C586(0.97); C365(0.91); C149(0.83); C73(1.03)  LDD1608  [24]
 LDCM0405  CL18 HEK-293T C586(1.06); C365(0.82); C149(1.16); C73(0.97)  LDD1609  [24]
 LDCM0406  CL19 HEK-293T C586(0.95); C365(0.80); C149(1.07); C73(1.00)  LDD1610  [24]
 LDCM0407  CL2 HEK-293T C586(0.93); C365(0.78); C149(0.95); C73(0.77)  LDD1611  [24]
 LDCM0408  CL20 HEK-293T C586(0.93); C365(0.89); C149(1.02); C73(0.92)  LDD1612  [24]
 LDCM0409  CL21 HEK-293T C586(1.04); C365(0.69); C149(0.99); C73(0.93)  LDD1613  [24]
 LDCM0410  CL22 HEK-293T C586(0.99); C365(0.87); C149(1.02); C73(1.00)  LDD1614  [24]
 LDCM0411  CL23 HEK-293T C586(0.91); C365(0.82); C149(1.04); C73(0.95)  LDD1615  [24]
 LDCM0412  CL24 HEK-293T C586(0.96); C365(0.88); C149(1.28); C73(1.01)  LDD1616  [24]
 LDCM0413  CL25 HEK-293T C586(0.88); C365(1.14); C149(0.85); C73(1.04)  LDD1617  [24]
 LDCM0414  CL26 HEK-293T C586(0.98); C365(0.68); C149(1.00); C73(0.93)  LDD1618  [24]
 LDCM0415  CL27 HEK-293T C586(1.01); C365(0.95); C149(1.08); C73(0.94)  LDD1619  [24]
 LDCM0416  CL28 HEK-293T C586(0.97); C365(0.94); C149(1.29); C73(1.10)  LDD1620  [24]
 LDCM0417  CL29 HEK-293T C586(0.99); C365(0.88); C149(0.90); C73(1.10)  LDD1621  [24]
 LDCM0418  CL3 HEK-293T C586(0.91); C365(0.87); C149(1.09); C73(0.93)  LDD1622  [24]
 LDCM0419  CL30 HEK-293T C586(0.96); C365(0.82); C149(0.95); C73(0.95)  LDD1623  [24]
 LDCM0420  CL31 HEK-293T C586(1.04); C365(0.79); C149(1.03); C73(0.97)  LDD1624  [24]
 LDCM0421  CL32 HEK-293T C586(1.07); C365(0.75); C149(0.79); C73(0.90)  LDD1625  [24]
 LDCM0422  CL33 HEK-293T C586(0.97); C365(0.71); C149(1.07); C73(1.00)  LDD1626  [24]
 LDCM0423  CL34 HEK-293T C586(0.94); C365(0.84); C149(1.03); C73(0.96)  LDD1627  [24]
 LDCM0424  CL35 HEK-293T C586(1.06); C365(0.84); C149(1.20); C73(1.05)  LDD1628  [24]
 LDCM0425  CL36 HEK-293T C586(1.04); C365(0.86); C149(1.19); C73(0.99)  LDD1629  [24]
 LDCM0426  CL37 HEK-293T C586(0.86); C365(1.12); C149(0.76); C73(1.03)  LDD1630  [24]
 LDCM0428  CL39 HEK-293T C586(0.98); C365(0.93); C149(1.25); C73(0.85)  LDD1632  [24]
 LDCM0429  CL4 HEK-293T C586(0.95); C365(0.92); C149(1.56); C73(0.97)  LDD1633  [24]
 LDCM0430  CL40 HEK-293T C586(0.98); C365(1.01); C149(1.35); C73(0.96)  LDD1634  [24]
 LDCM0431  CL41 HEK-293T C586(1.02); C365(0.89); C149(0.93); C73(0.91)  LDD1635  [24]
 LDCM0432  CL42 HEK-293T C586(0.99); C365(0.76); C149(1.14); C73(1.02)  LDD1636  [24]
 LDCM0433  CL43 HEK-293T C586(1.00); C365(0.80); C149(1.21); C73(1.00)  LDD1637  [24]
 LDCM0434  CL44 HEK-293T C586(1.11); C365(0.83); C149(1.07); C73(1.01)  LDD1638  [24]
 LDCM0435  CL45 HEK-293T C586(1.08); C365(0.72); C149(1.06); C73(0.97)  LDD1639  [24]
 LDCM0436  CL46 HEK-293T C586(0.99); C365(0.87); C149(1.20); C73(0.99)  LDD1640  [24]
 LDCM0437  CL47 HEK-293T C586(1.03); C365(0.67); C149(1.12); C73(1.06)  LDD1641  [24]
 LDCM0438  CL48 HEK-293T C586(0.99); C365(0.87); C149(1.14); C73(1.10)  LDD1642  [24]
 LDCM0439  CL49 HEK-293T C586(0.91); C365(1.15); C149(0.71); C73(0.96)  LDD1643  [24]
 LDCM0440  CL5 HEK-293T C586(0.96); C365(0.85); C149(1.18); C73(1.12)  LDD1644  [24]
 LDCM0441  CL50 HEK-293T C586(0.96); C365(0.88); C149(1.04); C73(0.94)  LDD1645  [24]
 LDCM0443  CL52 HEK-293T C586(0.95); C365(0.91); C149(1.12); C73(0.92)  LDD1646  [24]
 LDCM0444  CL53 HEK-293T C586(0.98); C365(0.84); C149(0.99); C73(0.89)  LDD1647  [24]
 LDCM0445  CL54 HEK-293T C586(0.92); C365(0.77); C149(1.21); C73(0.97)  LDD1648  [24]
 LDCM0446  CL55 HEK-293T C586(1.04); C365(0.84); C149(1.03); C73(1.09)  LDD1649  [24]
 LDCM0447  CL56 HEK-293T C586(1.04); C365(0.88); C149(0.93); C73(0.89)  LDD1650  [24]
 LDCM0448  CL57 HEK-293T C586(1.09); C365(0.68); C149(0.94); C73(1.14)  LDD1651  [24]
 LDCM0449  CL58 HEK-293T C586(1.00); C365(0.87); C149(1.31); C73(0.91)  LDD1652  [24]
 LDCM0450  CL59 HEK-293T C586(0.99); C365(0.63); C149(1.08); C73(0.97)  LDD1653  [24]
 LDCM0451  CL6 HEK-293T C586(0.97); C365(0.77); C149(1.10); C73(1.02)  LDD1654  [24]
 LDCM0452  CL60 HEK-293T C586(1.01); C365(0.91); C149(1.15); C73(1.12)  LDD1655  [24]
 LDCM0453  CL61 HEK-293T C586(0.87); C365(1.36); C149(0.80); C73(1.09)  LDD1656  [24]
 LDCM0454  CL62 HEK-293T C586(0.97); C365(0.99); C149(1.21); C73(0.91)  LDD1657  [24]
 LDCM0455  CL63 HEK-293T C586(1.01); C365(0.94); C149(1.10); C73(0.90)  LDD1658  [24]
 LDCM0456  CL64 HEK-293T C586(0.96); C365(0.94); C149(1.13); C73(0.82)  LDD1659  [24]
 LDCM0457  CL65 HEK-293T C586(0.96); C365(0.89); C149(0.87); C73(1.15)  LDD1660  [24]
 LDCM0458  CL66 HEK-293T C586(1.01); C365(0.88); C149(0.99); C73(1.02)  LDD1661  [24]
 LDCM0459  CL67 HEK-293T C586(1.02); C365(0.98); C149(0.88); C73(1.00)  LDD1662  [24]
 LDCM0460  CL68 HEK-293T C586(1.00); C365(0.87); C149(1.03); C73(0.95)  LDD1663  [24]
 LDCM0461  CL69 HEK-293T C586(1.04); C365(0.82); C149(0.94); C73(1.04)  LDD1664  [24]
 LDCM0462  CL7 HEK-293T C586(0.98); C365(0.75); C149(0.86); C73(0.98)  LDD1665  [24]
 LDCM0463  CL70 HEK-293T C586(1.00); C365(0.86); C149(1.13); C73(0.99)  LDD1666  [24]
 LDCM0464  CL71 HEK-293T C586(0.96); C365(0.69); C149(1.05); C73(0.93)  LDD1667  [24]
 LDCM0465  CL72 HEK-293T C586(1.01); C365(0.85); C149(0.98); C73(1.03)  LDD1668  [24]
 LDCM0466  CL73 HEK-293T C586(0.91); C365(1.06); C149(0.74); C73(1.01)  LDD1669  [24]
 LDCM0467  CL74 HEK-293T C586(0.92); C365(1.06); C149(1.05); C73(0.87)  LDD1670  [24]
 LDCM0469  CL76 HEK-293T C586(0.99); C365(1.10); C149(1.04); C73(1.10)  LDD1672  [24]
 LDCM0470  CL77 HEK-293T C586(1.04); C365(0.91); C149(1.13); C73(1.15)  LDD1673  [24]
 LDCM0471  CL78 HEK-293T C586(0.95); C365(0.85); C149(0.99); C73(0.98)  LDD1674  [24]
 LDCM0472  CL79 HEK-293T C586(0.95); C365(0.81); C149(1.21); C73(0.96)  LDD1675  [24]
 LDCM0473  CL8 HEK-293T C586(1.01); C365(0.66); C149(0.97); C73(0.74)  LDD1676  [24]
 LDCM0474  CL80 HEK-293T C586(1.04); C365(0.81); C149(0.89); C73(1.02)  LDD1677  [24]
 LDCM0475  CL81 HEK-293T C586(0.99); C365(0.76); C149(1.03); C73(1.09)  LDD1678  [24]
 LDCM0476  CL82 HEK-293T C586(0.96); C365(0.83); C149(1.11); C73(1.01)  LDD1679  [24]
 LDCM0477  CL83 HEK-293T C586(0.97); C365(0.69); C149(1.04); C73(0.97)  LDD1680  [24]
 LDCM0478  CL84 HEK-293T C586(0.98); C365(0.74); C149(1.16); C73(1.00)  LDD1681  [24]
 LDCM0479  CL85 HEK-293T C586(0.87); C365(1.19); C149(0.87); C73(0.88)  LDD1682  [24]
 LDCM0480  CL86 HEK-293T C586(0.95); C365(0.71); C149(1.03); C73(1.00)  LDD1683  [24]
 LDCM0481  CL87 HEK-293T C586(0.87); C365(0.94); C149(1.10); C73(0.93)  LDD1684  [24]
 LDCM0482  CL88 HEK-293T C586(0.97); C365(0.98); C149(1.35); C73(0.98)  LDD1685  [24]
 LDCM0483  CL89 HEK-293T C586(0.95); C365(0.84); C149(0.91); C73(1.02)  LDD1686  [24]
 LDCM0484  CL9 HEK-293T C586(1.05); C365(0.89); C149(1.13); C73(1.04)  LDD1687  [24]
 LDCM0485  CL90 HEK-293T C586(1.02); C365(0.71); C149(0.50); C73(0.86)  LDD1688  [24]
 LDCM0486  CL91 HEK-293T C586(0.97); C365(0.88); C149(1.09); C73(1.04)  LDD1689  [24]
 LDCM0487  CL92 HEK-293T C586(0.95); C365(0.84); C149(0.92); C73(0.83)  LDD1690  [24]
 LDCM0488  CL93 HEK-293T C586(0.99); C365(0.75); C149(1.02); C73(1.02)  LDD1691  [24]
 LDCM0489  CL94 HEK-293T C586(1.00); C365(0.87); C149(1.23); C73(0.98)  LDD1692  [24]
 LDCM0490  CL95 HEK-293T C586(1.10); C365(0.52); C149(1.04); C73(0.98)  LDD1693  [24]
 LDCM0491  CL96 HEK-293T C586(0.94); C365(0.78); C149(1.29); C73(0.99)  LDD1694  [24]
 LDCM0492  CL97 HEK-293T C586(0.98); C365(1.15); C149(0.85); C73(0.94)  LDD1695  [24]
 LDCM0493  CL98 HEK-293T C586(0.97); C365(1.07); C149(1.10); C73(0.85)  LDD1696  [24]
 LDCM0494  CL99 HEK-293T C586(1.06); C365(1.09); C149(1.14); C73(1.07)  LDD1697  [24]
 LDCM0495  E2913 HEK-293T C586(1.02); C365(0.97); C149(1.00); C73(0.88)  LDD1698  [24]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C73(1.10)  LDD1702  [4]
 LDCM0625  F8 Ramos C73(1.38)  LDD2187  [26]
 LDCM0572  Fragment10 Ramos C73(1.16)  LDD2189  [26]
 LDCM0573  Fragment11 Ramos C73(0.71)  LDD2190  [26]
 LDCM0574  Fragment12 Ramos C73(0.70)  LDD2191  [26]
 LDCM0575  Fragment13 Ramos C73(0.80)  LDD2192  [26]
 LDCM0576  Fragment14 Ramos C73(0.52)  LDD2193  [26]
 LDCM0579  Fragment20 Ramos C73(0.68)  LDD2194  [26]
 LDCM0580  Fragment21 Ramos C73(0.79)  LDD2195  [26]
 LDCM0582  Fragment23 Ramos C73(0.90)  LDD2196  [26]
 LDCM0578  Fragment27 Ramos C73(0.99)  LDD2197  [26]
 LDCM0586  Fragment28 Ramos C73(0.83)  LDD2198  [26]
 LDCM0588  Fragment30 Ramos C73(1.25)  LDD2199  [26]
 LDCM0589  Fragment31 Ramos C73(1.13)  LDD2200  [26]
 LDCM0590  Fragment32 Ramos C73(0.81)  LDD2201  [26]
 LDCM0468  Fragment33 HEK-293T C586(0.94); C365(0.96); C149(1.24); C73(0.91)  LDD1671  [24]
 LDCM0596  Fragment38 Ramos C73(1.04)  LDD2203  [26]
 LDCM0566  Fragment4 Ramos C73(0.62)  LDD2184  [26]
 LDCM0427  Fragment51 HEK-293T C586(0.98); C365(0.93); C149(1.15); C73(0.84)  LDD1631  [24]
 LDCM0610  Fragment52 Ramos C73(1.21)  LDD2204  [26]
 LDCM0614  Fragment56 Ramos C73(1.08)  LDD2205  [26]
 LDCM0569  Fragment7 Ramos C73(0.86)  LDD2186  [26]
 LDCM0571  Fragment9 Ramos C73(0.84)  LDD2188  [26]
 LDCM0022  KB02 HEK-293T C586(0.90); C365(1.07); C73(1.00); C389(0.90)  LDD1492  [24]
 LDCM0023  KB03 HEK-293T C586(1.01); C365(0.91); C73(1.04); C389(0.95)  LDD1497  [24]
 LDCM0024  KB05 COLO792 C586(3.80); C73(1.15); C149(4.17); C365(2.45)  LDD3310  [27]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C365(1.17)  LDD2092  [4]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C365(1.03)  LDD2098  [4]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C586(0.90)  LDD2100  [4]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C365(0.75)  LDD2104  [4]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C365(1.65)  LDD2105  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C365(1.13)  LDD2107  [4]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C586(1.02)  LDD2108  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C365(1.14)  LDD2111  [4]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C365(0.56)  LDD2114  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C365(1.42)  LDD2119  [4]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C365(0.81)  LDD2122  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C365(0.73)  LDD2125  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C365(1.04)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C365(0.66)  LDD2137  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C365(0.92)  LDD2140  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C365(0.40); C586(0.74)  LDD2141  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C365(1.19)  LDD2144  [4]
 LDCM0627  NUDT7-COV-1 HEK-293T C586(1.86)  LDD2206  [28]
 LDCM0628  OTUB2-COV-1 HEK-293T C586(0.79)  LDD2207  [28]
 LDCM0019  Staurosporine Hep-G2 N.A.  LDD0083  [23]

References

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Mass spectrometry data entry: PXD039908 , PXD029761
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Mass spectrometry data entry: PXD044625
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Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
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Mass spectrometry data entry: PXD022279
14 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
15 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
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Mass spectrometry data entry: PXD033004
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Mass spectrometry data entry: PXD044402
25 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
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Mass spectrometry data entry: PXD027578
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Mass spectrometry data entry: PXD047840
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