General Information of Experiment

Probe Name YN-1  Probe Info 
Probe concentration 100 uM
Criteria Qualitation: Labeling site identification
In Vivo Experiment Model Model Type Living cell
Derived Tissue Liver
Disease Model Hepatoblastoma [ICD-11:DB91]
Model Name Human hepatoblastoma cells (Hep-G2)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 99 Protein Related to This Bioclass
Target ID Target Name Binding Sites
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1) C237
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1) C447
 LDTP10322  Abasic site processing protein HMCES (HMCES) E231
 LDTP10322  Abasic site processing protein HMCES (HMCES) E236
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C119
 LDTP05059  Actin, cytoplasmic 2 (ACTG1) D154
 LDTP05059  Actin, cytoplasmic 2 (ACTG1) E167
 LDTP05059  Actin, cytoplasmic 2 (ACTG1) E99
 LDTP05059  Actin, cytoplasmic 2 (ACTG1) E100
 LDTP05059  Actin, cytoplasmic 2 (ACTG1) P38
 LDTP05059  Actin, cytoplasmic 2 (ACTG1) R39
 LDTP02587  Alcohol dehydrogenase class-3 (ADH5) C240
 LDTP01767  Aldehyde dehydrogenase 1A1 (ALDH1A1) C186
 LDTP04253  Alpha-aminoadipic semialdehyde dehydrogenase (ALDH7A1) C70
 LDTP09428  ATP-dependent RNA helicase DDX54 (DDX54) Y105
 LDTP12459  Baculoviral IAP repeat-containing protein 6 (BIRC6) C719
 LDTP05111  Casein kinase I isoform gamma-2 (CSNK1G2) Y163
 LDTP05111  Casein kinase I isoform gamma-2 (CSNK1G2) R164
 LDTP04686  Caspase-9 (CASP9) D23
 LDTP04686  Caspase-9 (CASP9) E18
 LDTP04686  Caspase-9 (CASP9) E19
 LDTP02198  Cathepsin D (CTSD) C329
 LDTP10716  CCA tRNA nucleotidyltransferase 1, mitochondrial (TRNT1) E413
 LDTP08583  Cell division cycle and apoptosis regulator protein 1 (CCAR1) E1059
 LDTP08583  Cell division cycle and apoptosis regulator protein 1 (CCAR1) E1060
 LDTP01393  cGMP-specific 3',5'-cyclic phosphodiesterase (PDE5A) P135
 LDTP01616  CTD nuclear envelope phosphatase 1 (CTDNEP1) D92
 LDTP05809  Dehydrogenase/reductase SDR family member 2, mitochondrial (DHRS2) C92
 LDTP05809  Dehydrogenase/reductase SDR family member 2, mitochondrial (DHRS2) C212
 LDTP04646  Delta-1-pyrroline-5-carboxylate synthase (ALDH18A1) D623
 LDTP04646  Delta-1-pyrroline-5-carboxylate synthase (ALDH18A1) D631
 LDTP04646  Delta-1-pyrroline-5-carboxylate synthase (ALDH18A1) D635
 LDTP03398  DNA repair nuclease/redox regulator APEX1 (APEX1) C93
 LDTP03398  DNA repair nuclease/redox regulator APEX1 (APEX1) C208
 LDTP03808  Dual specificity mitogen-activated protein kinase kinase 2 (MAP2K2) D194
 LDTP12151  Dual specificity protein kinase CLK4 (CLK4) E160
 LDTP12151  Dual specificity protein kinase CLK4 (CLK4) E167
 LDTP05071  Elongation factor 1-alpha 1 (EEF1A1) C234
 LDTP05071  Elongation factor 1-alpha 1 (EEF1A1) C411
 LDTP10386  ERO1-like protein alpha (ERO1A) C166
 LDTP16843  F-box and WD repeat domain containing protein 10B (FBXW10B) R55
 LDTP04243  Fatty acid synthase (FASN) C1992
 LDTP03133  Fibroblast growth factor receptor 2 (FGFR2) Y588
 LDTP03133  Fibroblast growth factor receptor 2 (FGFR2) S587
 LDTP03133  Fibroblast growth factor receptor 2 (FGFR2) P581
 LDTP10420  Germ cell-less protein-like 1 (GMCL1) D492
 LDTP04185  Glutamate--cysteine ligase catalytic subunit (GCLC) C152
 LDTP02410  Glutathione S-transferase theta-2B (GSTT2B) D34
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) C247
 LDTP00475  Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB) E631
 LDTP05859  Integrin-linked protein kinase (ILK) C422
 LDTP03817  Lon protease homolog, mitochondrial (LONP1) D412
 LDTP03817  Lon protease homolog, mitochondrial (LONP1) E410
 LDTP03908  Malate dehydrogenase, mitochondrial (MDH2) C285
 LDTP03908  Malate dehydrogenase, mitochondrial (MDH2) C212
 LDTP01540  Methyl-CpG-binding domain protein 4 (MBD4) E343
 LDTP00725  Mitogen-activated protein kinase kinase kinase 13 (MAP3K13) R198
 LDTP03765  Myosin-10 (MYH10) D1038
 LDTP03765  Myosin-10 (MYH10) E1041
 LDTP10681  NADPH oxidase 5 (NOX5) C153
 LDTP06346  Nicotinate-nucleotide pyrophosphorylase [carboxylating] (QPRT) C27
 LDTP10878  Parkinson disease protein 7 (PARK7) C53
 LDTP05028  Peptidyl-prolyl cis-trans isomerase A (PPIA) C115
 LDTP05503  Peroxiredoxin-1 (PRDX1) C173
 LDTP15014  Phosphatidylinositol 4-phosphate 5-kinase-like protein 1 (PIP5KL1) D279
 LDTP01787  Phosphoglycerate kinase 1 (PGK1) C108
 LDTP01787  Phosphoglycerate kinase 1 (PGK1) C316
 LDTP02963  Phosphoglycerate mutase 1 (PGAM1) C153
 LDTP00527  Phosphoribosylformylglycinamidine synthase (PFAS) C871
 LDTP06338  Prostaglandin E synthase 3 (PTGES3) C58
 LDTP03413  Proteasome subunit alpha type-5 (PSMA5) C165
 LDTP05433  Protein kinase C theta type (PRKCQ) D379
 LDTP13460  Protein mono-ADP-ribosyltransferase PARP4 (PARP4) D355
 LDTP13460  Protein mono-ADP-ribosyltransferase PARP4 (PARP4) E361
 LDTP03496  Protein PML (PML) C389
 LDTP07110  Putative transferase CAF17, mitochondrial (IBA57) Y143
 LDTP07110  Putative transferase CAF17, mitochondrial (IBA57) R144
 LDTP18953  Putative ubiquitin carboxyl-terminal hydrolase 17-like protein 23 (USP17L23) S72
 LDTP18953  Putative ubiquitin carboxyl-terminal hydrolase 17-like protein 23 (USP17L23) R73
 LDTP02733  Pyruvate kinase PKM (PKM) E272
 LDTP02733  Pyruvate kinase PKM (PKM) C358
 LDTP02733  Pyruvate kinase PKM (PKM) C49
 LDTP02733  Pyruvate kinase PKM (PKM) C326
 LDTP08685  Ras and EF-hand domain-containing protein (RASEF) N346
 LDTP08685  Ras and EF-hand domain-containing protein (RASEF) R347
 LDTP10712  Serine/threonine-protein kinase LMTK3 (LMTK3) E884
 LDTP05064  Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PPP2CA) C196
 LDTP12473  Sialic acid synthase (NANS) C8
 LDTP07414  Sulfotransferase 1C3 (SULT1C3) E5
 LDTP13156  SUMO-activating enzyme subunit 2 (UBA2) E471
 LDTP00047  Threonine--tRNA ligase 2, cytoplasmic (TARS3) E685
 LDTP09749  Titin (TTN) C7078
 LDTP04090  Transcriptional regulator ATRX (ATRX) E903
 LDTP09747  Transmembrane O-methyltransferase (TOMT) E173
 LDTP13344  Tyrosine-protein kinase BAZ1B (BAZ1B) D1407
 LDTP11015  Tyrosine-protein phosphatase non-receptor type 18 (PTPN18) E133
 LDTP11015  Tyrosine-protein phosphatase non-receptor type 18 (PTPN18) E135
 LDTP16509  Ubiquitin-conjugating enzyme E2 L5 (UBE2L5) C86
 LDTP00197  Unconventional myosin-If (MYO1F) R730
Transporter and channel
Click to Show/Hide to Show 19 Protein Related to This Bioclass
Target ID Target Name Binding Sites
 LDTP03402  Calreticulin (CALR) C105
 LDTP00244  Chloride intracellular channel protein 1 (CLIC1) C223
 LDTP00244  Chloride intracellular channel protein 1 (CLIC1) C178
 LDTP14222  Chloride intracellular channel protein 4 (CLIC4) C189
 LDTP05510  Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP) C186
 LDTP05292  Fatty acid-binding protein 5 (FABP5) C87
 LDTP00419  Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF1) E108
 LDTP17054  Neuronatin (NNAT) R69
 LDTP09771  Piezo-type mechanosensitive ion channel component 1 (PIEZO1) S94
 LDTP09771  Piezo-type mechanosensitive ion channel component 1 (PIEZO1) P93
 LDTP12276  Short transient receptor potential channel 7 (TRPC7) R855
 LDTP03645  Sodium/calcium exchanger 1 (SLC8A1) S635
 LDTP16037  Solute carrier family 38 member 10 (SLC38A10) D674
 LDTP04391  T-complex protein 1 subunit delta (CCT4) D311
 LDTP14031  Talin-1 (TLN1) C1045
 LDTP14057  Talin-2 (TLN2) D540
 LDTP14057  Talin-2 (TLN2) E541
 LDTP15033  VWFA and cache domain-containing protein 1 (CACHD1) D877
 LDTP15033  VWFA and cache domain-containing protein 1 (CACHD1) E871
Transcription factor
Click to Show/Hide to Show 9 Protein Related to This Bioclass
Target ID Target Name Binding Sites
 LDTP04564  CCAAT/enhancer-binding protein gamma (CEBPG) R103
 LDTP10501  DnaJ homolog subfamily C member 1 (DNAJC1) E389
 LDTP13295  General transcription factor II-I repeat domain-containing protein 1 (GTF2IRD1) D83
 LDTP13295  General transcription factor II-I repeat domain-containing protein 1 (GTF2IRD1) E79
 LDTP02523  Retinoic acid receptor beta (RARB) C130
 LDTP12989  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related (HMG20B) S228
 LDTP12989  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related (HMG20B) R231
 LDTP06592  T-box brain protein 1 (TBR1) E303
 LDTP08241  Zinc finger protein 589 (ZNF589) E66
GPCR
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Sites
 LDTP16669  Olfactory receptor 6C76 (OR6C76) R231
 LDTP08658  Psychosine receptor (GPR65) S326
Other
Click to Show/Hide to Show 104 Protein Related to This Bioclass
Target ID Target Name Binding Sites
 LDTP05969  43 kDa receptor-associated protein of the synapse (RAPSN) D38
 LDTP03871  Acidic leucine-rich nuclear phosphoprotein 32 family member A (ANP32A) C123
 LDTP00372  Acyl carrier protein, mitochondrial (NDUFAB1) C140
 LDTP17314  Ankyrin repeat domain-containing protein 40 (ANKRD40) D323
 LDTP11744  Beta-soluble NSF attachment protein (NAPB) S24
 LDTP14237  Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (ARFGEF2) D1504
 LDTP14237  Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (ARFGEF2) D1506
 LDTP14237  Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (ARFGEF2) D1508
 LDTP14237  Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (ARFGEF2) D1516
 LDTP19245  BTB/POZ domain-containing protein KCTD19 (KCTD19) D643
 LDTP05579  Calmodulin-regulated spectrin-associated protein 2 (CAMSAP2) R1179
 LDTP03711  Catenin alpha-1 (CTNNA1) P585
 LDTP08760  Cell cycle and apoptosis regulator protein 2 (CCAR2) E872
 LDTP08760  Cell cycle and apoptosis regulator protein 2 (CCAR2) E873
 LDTP06886  Centrosomal protein of 55 kDa (CEP55) S40
 LDTP05615  Cingulin-like protein 1 (CGNL1) E1096
 LDTP03244  Cofilin-1 (CFL1) C139
 LDTP15781  Coiled-coil domain-containing protein 138 (CCDC138) D297
 LDTP15781  Coiled-coil domain-containing protein 138 (CCDC138) E291
 LDTP15781  Coiled-coil domain-containing protein 138 (CCDC138) E292
 LDTP17814  Coiled-coil domain-containing protein 148 (CCDC148) C308
 LDTP03867  Collagen alpha-1(XVIII) chain (COL18A1) P1493
 LDTP03867  Collagen alpha-1(XVIII) chain (COL18A1) R1491
 LDTP07710  Collagen and calcium-binding EGF domain-containing protein 1 (CCBE1) P223
 LDTP15941  COMM domain-containing protein 5 (COMMD5) D42
 LDTP15941  COMM domain-containing protein 5 (COMMD5) D44
 LDTP11963  CUB domain-containing protein 1 (CDCP1) S514
 LDTP08775  Dedicator of cytokinesis protein 4 (DOCK4) D687
 LDTP08187  Disheveled-associated activator of morphogenesis 2 (DAAM2) D339
 LDTP15351  DNA damage-induced apoptosis suppressor protein (DDIAS) Y633
 LDTP13152  DnaJ homolog subfamily B member 11 (DNAJB11) D40
 LDTP12677  DnaJ homolog subfamily C member 11 (DNAJC11) D475
 LDTP05614  Dynein axonemal heavy chain 14 (DNAH14) E1224
 LDTP05614  Dynein axonemal heavy chain 14 (DNAH14) E1227
 LDTP05386  Dystonin (DST) D7302
 LDTP03499  Elongation factor 1-delta (EEF1D) C217
 LDTP03367  Elongation factor 1-gamma (EEF1G) C266
 LDTP11144  Endoplasmic reticulum resident protein 44 (ERP44) C318
 LDTP09884  Envoplakin (EVPL) D1271
 LDTP09884  Envoplakin (EVPL) E1269
 LDTP07947  Eukaryotic translation initiation factor 3 subunit M (EIF3M) C134
 LDTP04743  Eukaryotic translation initiation factor 6 (EIF6) C110
 LDTP06598  Fascin (FSCN1) C61
 LDTP14052  FERM, ARHGEF and pleckstrin domain-containing protein 1 (FARP1) D349
 LDTP07851  FYVE, RhoGEF and PH domain-containing protein 6 (FGD6) D1036
 LDTP03762  Glycogen debranching enzyme (AGL) E14
 LDTP08543  GRIP and coiled-coil domain-containing protein 2 (GCC2) E1144
 LDTP08543  GRIP and coiled-coil domain-containing protein 2 (GCC2) E1146
 LDTP02435  Heat shock 70 kDa protein 1B (HSPA1B) C603
 LDTP04952  Heterogeneous nuclear ribonucleoprotein K (HNRNPK) C132
 LDTP02750  Heterogeneous nuclear ribonucleoprotein L (HNRNPL) C472
 LDTP07016  IQ motif and SEC7 domain-containing protein 2 (IQSEC2) D60
 LDTP04593  IST1 homolog (IST1) E113
 LDTP04593  IST1 homolog (IST1) E116
 LDTP17387  Kelch-like protein 35 (KLHL35) E254
 LDTP07926  Kinase non-catalytic C-lobe domain-containing protein 1 (KNDC1) D293
 LDTP07926  Kinase non-catalytic C-lobe domain-containing protein 1 (KNDC1) D295
 LDTP07926  Kinase non-catalytic C-lobe domain-containing protein 1 (KNDC1) E291
 LDTP05021  Large ribosomal subunit protein eL30 (RPL30) C92
 LDTP02107  Large ribosomal subunit protein P1 (RPLP1) C61
 LDTP05008  Large ribosomal subunit protein uL14 (RPL23) C28
 LDTP04105  Large ribosomal subunit protein uL15 (RPL27A) C70
 LDTP03815  Large ribosomal subunit protein uL4 (RPL4) C208
 LDTP03997  Leucine-rich PPR motif-containing protein, mitochondrial (LRPPRC) C484
 LDTP19213  Leucine-rich repeat-containing protein 63 (LRRC63) R564
 LDTP03091  Nebulin (NEB) D2982
 LDTP01429  Nucleolar protein 4 (NOL4) Y143
 LDTP01429  Nucleolar protein 4 (NOL4) S142
 LDTP01429  Nucleolar protein 4 (NOL4) P147
 LDTP13925  Nucleolar protein 58 (NOP58) D452
 LDTP13925  Nucleolar protein 58 (NOP58) E453
 LDTP13925  Nucleolar protein 58 (NOP58) E456
 LDTP03151  Oxysterol-binding protein 1 (OSBP) D730
 LDTP03520  Phosphatidylethanolamine-binding protein 1 (PEBP1) C168
 LDTP04015  Platelet-activating factor acetylhydrolase IB subunit beta (PAFAH1B1) D44
 LDTP04015  Platelet-activating factor acetylhydrolase IB subunit beta (PAFAH1B1) E41
 LDTP04015  Platelet-activating factor acetylhydrolase IB subunit beta (PAFAH1B1) E42
 LDTP06330  Plectin (PLEC) E3753
 LDTP06330  Plectin (PLEC) E3761
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C158
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C194
 LDTP14522  Pre-mRNA cleavage complex 2 protein Pcf11 (PCF11) E201
 LDTP02596  Proliferating cell nuclear antigen (PCNA) C162
 LDTP02596  Proliferating cell nuclear antigen (PCNA) C135
 LDTP08984  Protein enabled homolog (ENAH) E149
 LDTP19743  Putative uncharacterized protein encoded by LINC00482 (LINC00482) E179
 LDTP04383  Ras association domain-containing protein 2 (RASSF2) D160
 LDTP05094  RNA-binding protein 6 (RBM6) D266
 LDTP04997  Small ribosomal subunit protein eS4, X isoform (RPS4X) C181
 LDTP02312  Small ribosomal subunit protein uS2 (RPSA) C148
 LDTP04110  Small ribosomal subunit protein uS7 (RPS5) C172
 LDTP01294  Small subunit processome component 20 homolog (UTP20) D2524
 LDTP01294  Small subunit processome component 20 homolog (UTP20) D2526
 LDTP10753  Sperm-associated antigen 5 (SPAG5) E1149
 LDTP03619  Stress-induced-phosphoprotein 1 (STIP1) C26
 LDTP06181  Structural maintenance of chromosomes protein 1A (SMC1A) P69
 LDTP09136  Structural maintenance of chromosomes protein 1B (SMC1B) Y823
 LDTP09136  Structural maintenance of chromosomes protein 1B (SMC1B) S824
 LDTP09230  Syntaxin-binding protein 6 (STXBP6) R182
 LDTP04390  T-complex protein 1 subunit theta (CCT8) C244
 LDTP11414  Testis-expressed protein 12 (TEX12) E108
 LDTP06659  Tumor protein D53 (TPD52L1) E66
 LDTP02322  U1 small nuclear ribonucleoprotein A (SNRPA) D92
 LDTP05641  WASH complex subunit 5 (WASHC5) D357

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.