Details of the Target

General Information of Target

Target ID LDTP13295
Target Name General transcription factor II-I repeat domain-containing protein 1 (GTF2IRD1)
Gene Name GTF2IRD1
Gene ID 9569
Synonyms
CREAM1; GTF3; MUSTRD1; RBAP2; WBSCR11; WBSCR12; General transcription factor II-I repeat domain-containing protein 1; GTF2I repeat domain-containing protein 1; General transcription factor III; MusTRD1/BEN; Muscle TFII-I repeat domain-containing protein 1; Slow-muscle-fiber enhancer-binding protein; USE B1-binding protein; Williams-Beuren syndrome chromosomal region 11 protein; Williams-Beuren syndrome chromosomal region 12 protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVS
DRFWVRGEGPIFFYTGNEGDVWAFANNSAFVAELAAERGALLVFAEHRYYGKSLPFGAQS
TQRGHTELLTVEQALADFAELLRALRRDLGAQDAPAIAFGGSYGGMLSAYLRMKYPHLVA
GALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDTVR
WEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRLLSEA
QRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACTEINLTFA
SNNVTDMFPDLPFTDELRQRYCLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLDPW
AGGGIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASVVEARKLEATIIGEWVKAARREQ
QPALRGGPRLSL
Target Bioclass
Transcription factor
Family
TFII-I family
Subcellular location
Nucleus
Function
May be a transcription regulator involved in cell-cycle progression and skeletal muscle differentiation. May repress GTF2I transcriptional functions, by preventing its nuclear residency, or by inhibiting its transcriptional activation. May contribute to slow-twitch fiber type specificity during myogenesis and in regenerating muscles. Binds troponin I slow-muscle fiber enhancer (USE B1). Binds specifically and with high affinity to the EFG sequences derived from the early enhancer of HOXC8.
Uniprot ID
Q9UHL9
Ensemble ID
ENST00000265755.7
HGNC ID
HGNC:4661

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C434(3.32)  LDD3310  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0164  [2]
IPM
 Probe Info  		N.A.  LDD0147  [3]
YN-1
 Probe Info  		D83(0.00); E79(0.00)  LDD0446  [4]
NAIA_5
 Probe Info  		N.A.  LDD2223  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0237  AC12 HEK-293T C230(1.09)  LDD1510  [6]
 LDCM0259  AC14 HEK-293T C230(1.03)  LDD1512  [6]
 LDCM0270  AC15 HEK-293T C230(1.22)  LDD1513  [6]
 LDCM0280  AC20 HEK-293T C230(1.05)  LDD1519  [6]
 LDCM0282  AC22 HEK-293T C230(0.81)  LDD1521  [6]
 LDCM0283  AC23 HEK-293T C230(1.05)  LDD1522  [6]
 LDCM0284  AC24 HEK-293T C230(0.91)  LDD1523  [6]
 LDCM0288  AC28 HEK-293T C230(1.09)  LDD1527  [6]
 LDCM0291  AC30 HEK-293T C230(1.04)  LDD1530  [6]
 LDCM0292  AC31 HEK-293T C230(1.11)  LDD1531  [6]
 LDCM0293  AC32 HEK-293T C230(0.96)  LDD1532  [6]
 LDCM0297  AC36 HEK-293T C230(0.93)  LDD1536  [6]
 LDCM0299  AC38 HEK-293T C230(1.06)  LDD1538  [6]
 LDCM0300  AC39 HEK-293T C230(1.13)  LDD1539  [6]
 LDCM0301  AC4 HEK-293T C230(1.08)  LDD1540  [6]
 LDCM0302  AC40 HEK-293T C230(0.93)  LDD1541  [6]
 LDCM0306  AC44 HEK-293T C230(1.15)  LDD1545  [6]
 LDCM0308  AC46 HEK-293T C230(1.19)  LDD1547  [6]
 LDCM0309  AC47 HEK-293T C230(1.15)  LDD1548  [6]
 LDCM0310  AC48 HEK-293T C230(0.79)  LDD1549  [6]
 LDCM0315  AC52 HEK-293T C230(1.07)  LDD1554  [6]
 LDCM0317  AC54 HEK-293T C230(0.83)  LDD1556  [6]
 LDCM0318  AC55 HEK-293T C230(0.99)  LDD1557  [6]
 LDCM0319  AC56 HEK-293T C230(0.96)  LDD1558  [6]
 LDCM0323  AC6 HEK-293T C230(1.01)  LDD1562  [6]
 LDCM0324  AC60 HEK-293T C230(1.09)  LDD1563  [6]
 LDCM0326  AC62 HEK-293T C230(0.97)  LDD1565  [6]
 LDCM0327  AC63 HEK-293T C230(1.01)  LDD1566  [6]
 LDCM0328  AC64 HEK-293T C230(0.98)  LDD1567  [6]
 LDCM0334  AC7 HEK-293T C230(0.98)  LDD1568  [6]
 LDCM0345  AC8 HEK-293T C230(0.89)  LDD1569  [6]
 LDCM0275  AKOS034007705 HEK-293T C230(0.95)  LDD1514  [6]
 LDCM0632  CL-Sc Hep-G2 C885(20.00)  LDD2227  [5]
 LDCM0368  CL10 HEK-293T C230(0.87)  LDD1572  [6]
 LDCM0371  CL102 HEK-293T C230(0.83); C480(1.08)  LDD1575  [6]
 LDCM0375  CL106 HEK-293T C230(0.96); C480(1.07)  LDD1579  [6]
 LDCM0379  CL11 HEK-293T C230(1.06)  LDD1583  [6]
 LDCM0380  CL110 HEK-293T C230(0.88); C480(1.02)  LDD1584  [6]
 LDCM0384  CL114 HEK-293T C230(0.99); C480(1.08)  LDD1588  [6]
 LDCM0388  CL118 HEK-293T C230(1.17); C480(1.07)  LDD1592  [6]
 LDCM0390  CL12 HEK-293T C230(0.94)  LDD1594  [6]
 LDCM0393  CL122 HEK-293T C230(0.98); C480(1.09)  LDD1597  [6]
 LDCM0397  CL126 HEK-293T C230(0.90); C480(1.11)  LDD1601  [6]
 LDCM0401  CL14 HEK-293T C230(0.91); C480(1.03)  LDD1605  [6]
 LDCM0407  CL2 HEK-293T C230(0.90); C480(0.97)  LDD1611  [6]
 LDCM0408  CL20 HEK-293T C230(1.03)  LDD1612  [6]
 LDCM0410  CL22 HEK-293T C230(1.01)  LDD1614  [6]
 LDCM0411  CL23 HEK-293T C230(0.97)  LDD1615  [6]
 LDCM0412  CL24 HEK-293T C230(0.99)  LDD1616  [6]
 LDCM0414  CL26 HEK-293T C230(0.82); C480(1.02)  LDD1618  [6]
 LDCM0421  CL32 HEK-293T C230(0.99)  LDD1625  [6]
 LDCM0423  CL34 HEK-293T C230(0.88)  LDD1627  [6]
 LDCM0424  CL35 HEK-293T C230(1.12)  LDD1628  [6]
 LDCM0425  CL36 HEK-293T C230(0.92)  LDD1629  [6]
 LDCM0434  CL44 HEK-293T C230(1.04)  LDD1638  [6]
 LDCM0436  CL46 HEK-293T C230(0.99)  LDD1640  [6]
 LDCM0437  CL47 HEK-293T C230(1.10)  LDD1641  [6]
 LDCM0438  CL48 HEK-293T C230(1.10)  LDD1642  [6]
 LDCM0441  CL50 HEK-293T C230(0.79); C480(1.08)  LDD1645  [6]
 LDCM0447  CL56 HEK-293T C230(1.06)  LDD1650  [6]
 LDCM0449  CL58 HEK-293T C230(0.86)  LDD1652  [6]
 LDCM0450  CL59 HEK-293T C230(1.07)  LDD1653  [6]
 LDCM0452  CL60 HEK-293T C230(0.96)  LDD1655  [6]
 LDCM0454  CL62 HEK-293T C230(0.97); C480(1.02)  LDD1657  [6]
 LDCM0460  CL68 HEK-293T C230(1.08)  LDD1663  [6]
 LDCM0463  CL70 HEK-293T C230(0.93)  LDD1666  [6]
 LDCM0464  CL71 HEK-293T C230(1.08)  LDD1667  [6]
 LDCM0465  CL72 HEK-293T C230(1.07)  LDD1668  [6]
 LDCM0467  CL74 HEK-293T C230(1.05); C480(1.11)  LDD1670  [6]
 LDCM0473  CL8 HEK-293T C230(1.03)  LDD1676  [6]
 LDCM0474  CL80 HEK-293T C230(1.01)  LDD1677  [6]
 LDCM0476  CL82 HEK-293T C230(0.91)  LDD1679  [6]
 LDCM0477  CL83 HEK-293T C230(1.11)  LDD1680  [6]
 LDCM0478  CL84 HEK-293T C230(0.88)  LDD1681  [6]
 LDCM0480  CL86 HEK-293T C230(0.80); C480(0.98)  LDD1683  [6]
 LDCM0487  CL92 HEK-293T C230(1.21)  LDD1690  [6]
 LDCM0489  CL94 HEK-293T C230(1.02)  LDD1692  [6]
 LDCM0490  CL95 HEK-293T C230(1.19)  LDD1693  [6]
 LDCM0491  CL96 HEK-293T C230(0.89)  LDD1694  [6]
 LDCM0493  CL98 HEK-293T C230(0.90); C480(1.00)  LDD1696  [6]
 LDCM0427  Fragment51 HEK-293T C230(0.93); C480(0.94)  LDD1631  [6]
 LDCM0022  KB02 HEK-293T C277(0.78)  LDD1492  [6]
 LDCM0023  KB03 HEK-293T C277(1.18)  LDD1497  [6]
 LDCM0024  KB05 COLO792 C434(3.32)  LDD3310  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DDB1- and CUL4-associated factor 6 (DCAF6) . Q58WW2
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger MYM-type protein 2 (ZMYM2) . Q9UBW7
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Plakophilin-1 (PKP1) Beta-catenin family Q13835
Golgi reassembly-stacking protein 2 (GORASP2) GORASP family Q9H8Y8
Integrator complex subunit 12 (INTS12) Integrator subunit 12 family Q96CB8
Methyl-CpG-binding domain protein 3-like 1 (MBD3L1) MBD3L family Q8WWY6
Activating transcription factor 7-interacting protein 1 (ATF7IP) MCAF family Q6VMQ6
MORF4 family-associated protein 1-like 1 (MRFAP1L1) MORF4 family-associated protein family Q96HT8

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402