Details of the Target

General Information of Target

Target ID LDTP11144
Target Name Endoplasmic reticulum resident protein 44 (ERP44)
Gene Name ERP44
Gene ID 23071
Synonyms
KIAA0573; TXNDC4; Endoplasmic reticulum resident protein 44; ER protein 44; ERp44; Thioredoxin domain-containing protein 4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNQEDLDPDSTTDVGDVTNTEEELIRECEEMWKDMEECQNKLSLIGTETLTDSNAQLSLL
IMQVKCLTAELSQWQKKTPETIPLTEDVLITLGKEEFQKLRQDLEMVLSTKESKNEKLKE
DLEREQRWLDEQQQIMESLNVLHSELKNKVETFSESRIFNELKTKMLNIKEYKEKLLSTL
GEFLEDHFPLPDRSVKKKKKNIQESSVNLITLHEMLEILINRLFDVPHDPYVKISDSFWP
PYVELLLRNGIALRHPEDPTRIRLEAFHQ
Target Bioclass
Other
Subcellular location
Endoplasmic reticulum lumen
Function
Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1A and ERO1B in the endoplasmic reticulum.
Uniprot ID
Q9BS26
Ensemble ID
ENST00000262455.7
HGNC ID
HGNC:18311

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 25 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		10.21  LDD0402  [1]
W1
 Probe Info  		14.72  LDD0235  [2]
STPyne
 Probe Info  		K130(10.00); K345(10.00)  LDD0277  [3]
OPA-S-S-alkyne
 Probe Info  		K130(2.57)  LDD3494  [4]
BTD
 Probe Info  		C92(2.00)  LDD1700  [5]
DBIA
 Probe Info  		C92(0.70)  LDD0532  [6]
5E-2FA
 Probe Info  		H65(0.00); H352(0.00); H186(0.00); H95(0.00)  LDD2235  [7]
ATP probe
 Probe Info  		N.A.  LDD0199  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C301(0.00); C318(0.00); C189(0.00); C92(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		C301(0.00); C189(0.00)  LDD0032  [10]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [11]
Lodoacetamide azide
 Probe Info  		C301(0.00); C318(0.00); C189(0.00); C92(0.00)  LDD0037  [9]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [12]
NAIA_4
 Probe Info  		N.A.  LDD2226  [13]
Compound 10
 Probe Info  		N.A.  LDD2216  [14]
IPM
 Probe Info  		N.A.  LDD0147  [12]
NHS
 Probe Info  		N.A.  LDD0010  [15]
SF
 Probe Info  		N.A.  LDD0028  [16]
TFBX
 Probe Info  		N.A.  LDD0148  [12]
YN-1
 Probe Info  		N.A.  LDD0446  [17]
Acrolein
 Probe Info  		C92(0.00); C318(0.00); H306(0.00)  LDD0217  [18]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [18]
Crotonaldehyde
 Probe Info  		C92(0.00); C318(0.00)  LDD0219  [18]
Methacrolein
 Probe Info  		C92(0.00); C318(0.00)  LDD0218  [18]
NAIA_5
 Probe Info  		C301(0.00); C318(0.00); C189(0.00); C92(0.00)  LDD2223  [13]
PAL-AfBPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C130
 Probe Info  		7.01  LDD1812  [19]
C282
 Probe Info  		14.72  LDD1952  [19]
FFF probe11
 Probe Info  		9.89  LDD0471  [20]
FFF probe13
 Probe Info  		14.66  LDD0475  [20]
FFF probe14
 Probe Info  		12.71  LDD0477  [20]
FFF probe2
 Probe Info  		7.63  LDD0463  [20]
FFF probe4
 Probe Info  		6.05  LDD0466  [20]
STS-1
 Probe Info  		N.A.  LDD0136  [21]
VE-P
 Probe Info  		N.A.  LDD0396  [22]
OEA-DA
 Probe Info  		17.15  LDD0046  [23]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C92(0.60)  LDD2142  [5]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C92(0.88); C241(0.67)  LDD2112  [5]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C92(1.05)  LDD2117  [5]
 LDCM0214  AC1 HEK-293T C92(0.91); C301(0.95); C189(0.99); C318(1.04)  LDD1507  [24]
 LDCM0215  AC10 HCT 116 C92(0.70)  LDD0532  [6]
 LDCM0226  AC11 HCT 116 C92(0.70)  LDD0543  [6]
 LDCM0230  AC113 PaTu 8988t C301(1.10)  LDD1109  [6]
 LDCM0231  AC114 PaTu 8988t C301(0.93)  LDD1110  [6]
 LDCM0232  AC115 PaTu 8988t C301(1.04)  LDD1111  [6]
 LDCM0233  AC116 PaTu 8988t C301(1.52)  LDD1112  [6]
 LDCM0234  AC117 PaTu 8988t C301(1.10)  LDD1113  [6]
 LDCM0235  AC118 PaTu 8988t C301(0.76)  LDD1114  [6]
 LDCM0236  AC119 PaTu 8988t C301(1.02)  LDD1115  [6]
 LDCM0237  AC12 HCT 116 C92(0.78)  LDD0554  [6]
 LDCM0238  AC120 PaTu 8988t C301(0.89)  LDD1117  [6]
 LDCM0239  AC121 PaTu 8988t C301(1.08)  LDD1118  [6]
 LDCM0240  AC122 PaTu 8988t C301(1.01)  LDD1119  [6]
 LDCM0241  AC123 PaTu 8988t C301(0.99)  LDD1120  [6]
 LDCM0242  AC124 PaTu 8988t C301(1.05)  LDD1121  [6]
 LDCM0243  AC125 PaTu 8988t C301(0.76)  LDD1122  [6]
 LDCM0244  AC126 PaTu 8988t C301(1.04)  LDD1123  [6]
 LDCM0245  AC127 PaTu 8988t C301(0.89)  LDD1124  [6]
 LDCM0259  AC14 HCT 116 C92(0.75)  LDD0576  [6]
 LDCM0263  AC143 HCT 116 C92(1.14)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C92(0.97)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C92(0.97)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C92(1.14)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C92(1.04)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C92(1.29)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C92(1.13)  LDD0586  [6]
 LDCM0270  AC15 HCT 116 C92(0.71)  LDD0587  [6]
 LDCM0271  AC150 HCT 116 C92(0.94)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C92(0.80)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C92(0.85)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C92(1.10)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C92(0.79)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C92(0.87)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C92(0.88)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C92(0.86)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C301(0.85)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C301(0.74)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C301(0.85)  LDD0595  [6]
 LDCM0279  AC2 HEK-293T C92(0.99); C301(0.99); C189(1.07); C318(0.95)  LDD1518  [24]
 LDCM0280  AC20 HCT 116 C301(0.88)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C301(0.85)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C301(0.83)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C301(0.75)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C301(0.94)  LDD0601  [6]
 LDCM0285  AC25 HEK-293T C92(1.00); C301(0.92); C189(0.98); C318(1.02)  LDD1524  [24]
 LDCM0286  AC26 HEK-293T C92(1.13); C301(0.98); C189(1.01); C318(1.02)  LDD1525  [24]
 LDCM0287  AC27 HEK-293T C92(0.96); C301(0.95); C189(0.99); C318(1.00)  LDD1526  [24]
 LDCM0288  AC28 HEK-293T C92(1.00); C301(0.99); C189(0.92); C318(1.09)  LDD1527  [24]
 LDCM0289  AC29 HEK-293T C92(0.96); C189(1.11); C318(0.98)  LDD1528  [24]
 LDCM0290  AC3 HEK-293T C92(0.91); C301(1.08); C189(1.01); C318(0.98)  LDD1529  [24]
 LDCM0291  AC30 HEK-293T C92(1.01); C301(0.98); C189(1.00); C318(1.01)  LDD1530  [24]
 LDCM0292  AC31 HEK-293T C92(1.04); C301(0.98); C189(1.02); C318(0.98)  LDD1531  [24]
 LDCM0293  AC32 HEK-293T C92(1.04); C301(0.97); C189(1.06); C318(1.02)  LDD1532  [24]
 LDCM0294  AC33 HEK-293T C92(1.01); C301(0.92); C189(1.00); C318(1.04)  LDD1533  [24]
 LDCM0295  AC34 HEK-293T C92(0.97); C301(1.06); C189(1.01); C318(1.03)  LDD1534  [24]
 LDCM0296  AC35 HCT 116 C301(1.01); C92(1.18)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C301(1.07); C92(1.19)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C301(1.02); C92(1.15)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C92(1.32); C301(1.33)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C92(1.06); C301(1.18)  LDD0617  [6]
 LDCM0301  AC4 HEK-293T C92(0.94); C301(1.00); C189(1.03); C318(1.00)  LDD1540  [24]
 LDCM0302  AC40 HCT 116 C301(0.89); C92(1.00)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C301(0.93); C92(1.26)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C301(1.11); C92(1.11)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C301(0.86); C92(1.01)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C92(0.95); C301(1.11)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C92(0.80); C301(0.99)  LDD0624  [6]
 LDCM0308  AC46 HCT 116 C92(0.92)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C92(1.04)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C92(0.77)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C92(0.60)  LDD0628  [6]
 LDCM0312  AC5 HEK-293T C92(0.97); C189(1.06); C318(1.08)  LDD1551  [24]
 LDCM0313  AC50 HCT 116 C92(0.75)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C92(1.24)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C92(1.11)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C92(0.87)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C92(0.89)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C92(0.65)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C92(0.30)  LDD0636  [6]
 LDCM0320  AC57 HCT 116 C92(0.68); C301(1.12)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C92(0.63); C301(1.02)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C92(0.63); C301(1.19)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C92(0.68)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C92(0.55); C301(1.16)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C92(0.48); C301(1.07)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C92(0.49); C301(1.01)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C92(0.53); C301(1.09)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C92(0.52); C301(0.98)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C92(0.61); C301(1.37)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C92(0.53); C301(1.29)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C92(0.17); C301(0.67)  LDD0648  [6]
 LDCM0334  AC7 HCT 116 C92(0.79)  LDD0651  [6]
 LDCM0345  AC8 HCT 116 C92(0.67)  LDD0662  [6]
 LDCM0545  Acetamide MDA-MB-231 C92(0.42)  LDD2138  [5]
 LDCM0248  AKOS034007472 HCT 116 C92(0.95)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C92(0.84)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C92(0.46)  LDD0592  [6]
 LDCM0156  Aniline NCI-H1299 12.29  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa C189(0.00); C318(0.00); C92(0.00); H186(0.00)  LDD0222  [18]
 LDCM0367  CL1 PaTu 8988t C92(0.87)  LDD1246  [6]
 LDCM0368  CL10 PaTu 8988t C92(0.48)  LDD1247  [6]
 LDCM0369  CL100 HEK-293T C92(0.86); C301(0.91); C189(1.02); C318(1.02)  LDD1573  [24]
 LDCM0370  CL101 HCT 116 C92(0.58)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C92(0.93)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C92(0.80)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C92(0.99)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C301(0.92)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C301(0.53)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C301(0.78)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C301(0.74)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C301(0.80)  LDD0695  [6]
 LDCM0379  CL11 PaTu 8988t C92(0.75)  LDD1258  [6]
 LDCM0380  CL110 HCT 116 C301(0.78)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C301(0.78)  LDD0698  [6]
 LDCM0382  CL112 HEK-293T C92(1.03); C301(0.99); C189(1.06); C318(0.92)  LDD1586  [24]
 LDCM0383  CL113 HEK-293T C92(0.98); C301(0.95); C189(1.02); C318(1.03)  LDD1587  [24]
 LDCM0384  CL114 HEK-293T C92(0.89); C301(0.97); C318(1.05)  LDD1588  [24]
 LDCM0385  CL115 HEK-293T C92(0.95); C301(0.94); C189(0.95); C318(1.00)  LDD1589  [24]
 LDCM0386  CL116 HEK-293T C92(0.98); C301(0.92); C189(1.01); C318(1.08)  LDD1590  [24]
 LDCM0387  CL117 HCT 116 C301(0.60); C92(0.67)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C92(1.04); C301(1.13)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C301(0.87); C92(1.12)  LDD0706  [6]
 LDCM0390  CL12 PaTu 8988t C92(1.05)  LDD1269  [6]
 LDCM0391  CL120 HCT 116 C92(1.14); C301(1.25)  LDD0708  [6]
 LDCM0392  CL121 HCT 116 C92(0.58)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C92(0.60)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C92(0.50)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C92(0.68)  LDD0712  [6]
 LDCM0396  CL125 HCT 116 C92(0.94); C301(1.20)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C92(0.69); C301(1.01)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C92(1.02); C301(1.20)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C92(0.98); C301(1.15)  LDD0716  [6]
 LDCM0400  CL13 PaTu 8988t C92(0.40)  LDD1279  [6]
 LDCM0401  CL14 PaTu 8988t C92(0.34)  LDD1280  [6]
 LDCM0402  CL15 PaTu 8988t C92(0.71)  LDD1281  [6]
 LDCM0403  CL16 PaTu 8988t C301(0.73); C92(0.65)  LDD1282  [6]
 LDCM0404  CL17 PaTu 8988t C301(0.93); C92(0.86)  LDD1283  [6]
 LDCM0405  CL18 PaTu 8988t C301(0.76); C92(0.66)  LDD1284  [6]
 LDCM0406  CL19 PaTu 8988t C301(0.69); C92(0.67)  LDD1285  [6]
 LDCM0407  CL2 PaTu 8988t C92(0.74)  LDD1286  [6]
 LDCM0408  CL20 PaTu 8988t C301(0.40); C92(0.57)  LDD1287  [6]
 LDCM0409  CL21 PaTu 8988t C301(0.25); C92(0.36)  LDD1288  [6]
 LDCM0410  CL22 PaTu 8988t C301(0.50); C92(0.46)  LDD1289  [6]
 LDCM0411  CL23 PaTu 8988t C301(0.38); C92(0.57)  LDD1290  [6]
 LDCM0412  CL24 PaTu 8988t C301(0.71); C92(0.70)  LDD1291  [6]
 LDCM0413  CL25 PaTu 8988t C301(0.60); C92(0.47)  LDD1292  [6]
 LDCM0414  CL26 PaTu 8988t C301(0.54); C92(0.58)  LDD1293  [6]
 LDCM0415  CL27 PaTu 8988t C301(0.89); C92(0.53)  LDD1294  [6]
 LDCM0416  CL28 PaTu 8988t C301(0.27); C92(0.37)  LDD1295  [6]
 LDCM0417  CL29 PaTu 8988t C301(0.24); C92(0.56)  LDD1296  [6]
 LDCM0418  CL3 PaTu 8988t C92(0.58)  LDD1297  [6]
 LDCM0419  CL30 PaTu 8988t C301(0.40); C92(0.60)  LDD1298  [6]
 LDCM0420  CL31 HCT 116 C301(0.67); C92(0.99)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C301(0.58); C92(0.93)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C301(0.44); C92(0.48)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C301(0.47); C92(0.79)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C301(0.60); C92(0.91)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C301(0.64); C92(1.33)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C301(0.71); C92(1.14)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C301(0.45); C92(0.66)  LDD0745  [6]
 LDCM0429  CL4 PaTu 8988t C92(0.61)  LDD1308  [6]
 LDCM0430  CL40 HCT 116 C301(0.65); C92(0.90)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C301(0.78); C92(1.43)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C301(0.36); C92(0.76)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C301(0.48); C92(0.87)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C301(0.45); C92(0.63)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C301(0.36); C92(0.60)  LDD0752  [6]
 LDCM0436  CL46 PaTu 8988t C301(1.05); C92(0.92)  LDD1315  [6]
 LDCM0437  CL47 PaTu 8988t C301(0.83); C92(0.90)  LDD1316  [6]
 LDCM0438  CL48 PaTu 8988t C301(0.87); C92(1.35)  LDD1317  [6]
 LDCM0439  CL49 PaTu 8988t C301(1.09); C92(1.18)  LDD1318  [6]
 LDCM0440  CL5 PaTu 8988t C92(0.76)  LDD1319  [6]
 LDCM0441  CL50 PaTu 8988t C301(1.06); C92(0.91)  LDD1320  [6]
 LDCM0442  CL51 PaTu 8988t C301(0.95); C92(1.43)  LDD1321  [6]
 LDCM0443  CL52 PaTu 8988t C301(0.96); C92(1.01)  LDD1322  [6]
 LDCM0444  CL53 PaTu 8988t C301(1.03); C92(1.00)  LDD1323  [6]
 LDCM0445  CL54 PaTu 8988t C301(1.07); C92(0.45)  LDD1324  [6]
 LDCM0446  CL55 PaTu 8988t C301(0.87); C92(0.89)  LDD1325  [6]
 LDCM0447  CL56 PaTu 8988t C301(0.91); C92(0.17)  LDD1326  [6]
 LDCM0448  CL57 PaTu 8988t C301(0.96); C92(0.42)  LDD1327  [6]
 LDCM0449  CL58 PaTu 8988t C301(0.91); C92(0.49)  LDD1328  [6]
 LDCM0450  CL59 PaTu 8988t C301(1.04); C92(0.28)  LDD1329  [6]
 LDCM0451  CL6 PaTu 8988t C92(0.69)  LDD1330  [6]
 LDCM0452  CL60 PaTu 8988t C301(0.87); C92(0.66)  LDD1331  [6]
 LDCM0453  CL61 PaTu 8988t C92(0.59)  LDD1332  [6]
 LDCM0454  CL62 PaTu 8988t C92(0.86)  LDD1333  [6]
 LDCM0455  CL63 PaTu 8988t C92(1.01)  LDD1334  [6]
 LDCM0456  CL64 PaTu 8988t C92(0.84)  LDD1335  [6]
 LDCM0457  CL65 PaTu 8988t C92(0.93)  LDD1336  [6]
 LDCM0458  CL66 PaTu 8988t C92(0.54)  LDD1337  [6]
 LDCM0459  CL67 PaTu 8988t C92(0.68)  LDD1338  [6]
 LDCM0460  CL68 PaTu 8988t C92(0.37)  LDD1339  [6]
 LDCM0461  CL69 PaTu 8988t C92(0.39)  LDD1340  [6]
 LDCM0462  CL7 PaTu 8988t C92(0.58)  LDD1341  [6]
 LDCM0463  CL70 PaTu 8988t C92(0.60)  LDD1342  [6]
 LDCM0464  CL71 PaTu 8988t C92(1.08)  LDD1343  [6]
 LDCM0465  CL72 PaTu 8988t C92(1.42)  LDD1344  [6]
 LDCM0466  CL73 PaTu 8988t C92(0.61)  LDD1345  [6]
 LDCM0467  CL74 PaTu 8988t C92(0.78)  LDD1346  [6]
 LDCM0469  CL76 PaTu 8988t C92(0.97)  LDD1348  [6]
 LDCM0470  CL77 PaTu 8988t C92(0.80)  LDD1349  [6]
 LDCM0471  CL78 PaTu 8988t C92(0.80)  LDD1350  [6]
 LDCM0472  CL79 PaTu 8988t C92(1.26)  LDD1351  [6]
 LDCM0473  CL8 PaTu 8988t C92(0.40)  LDD1352  [6]
 LDCM0474  CL80 PaTu 8988t C92(0.73)  LDD1353  [6]
 LDCM0475  CL81 PaTu 8988t C92(0.67)  LDD1354  [6]
 LDCM0476  CL82 PaTu 8988t C92(0.84)  LDD1355  [6]
 LDCM0477  CL83 PaTu 8988t C92(0.55)  LDD1356  [6]
 LDCM0478  CL84 PaTu 8988t C92(0.83)  LDD1357  [6]
 LDCM0479  CL85 PaTu 8988t C92(0.97)  LDD1358  [6]
 LDCM0480  CL86 PaTu 8988t C92(0.53)  LDD1359  [6]
 LDCM0481  CL87 PaTu 8988t C92(0.49)  LDD1360  [6]
 LDCM0482  CL88 PaTu 8988t C92(0.64)  LDD1361  [6]
 LDCM0483  CL89 PaTu 8988t C92(0.78)  LDD1362  [6]
 LDCM0484  CL9 PaTu 8988t C92(0.59)  LDD1363  [6]
 LDCM0485  CL90 PaTu 8988t C92(0.48)  LDD1364  [6]
 LDCM0486  CL91 HEK-293T C92(0.89); C301(0.99); C189(0.97); C318(1.11)  LDD1689  [24]
 LDCM0487  CL92 HEK-293T C92(0.93); C301(0.91); C189(1.09); C318(1.07)  LDD1690  [24]
 LDCM0488  CL93 HEK-293T C92(0.96); C189(1.23); C318(1.10)  LDD1691  [24]
 LDCM0489  CL94 HEK-293T C92(0.95); C301(1.01); C189(1.04); C318(1.03)  LDD1692  [24]
 LDCM0490  CL95 HEK-293T C92(0.90); C301(1.01); C189(0.90); C318(1.03)  LDD1693  [24]
 LDCM0491  CL96 HEK-293T C92(0.88); C301(1.03); C189(1.23); C318(0.96)  LDD1694  [24]
 LDCM0492  CL97 HEK-293T C92(0.97); C301(0.91); C189(1.19); C318(0.93)  LDD1695  [24]
 LDCM0493  CL98 HEK-293T C92(0.85); C301(1.05); C318(1.04)  LDD1696  [24]
 LDCM0494  CL99 HEK-293T C92(1.02); C301(0.99); C189(1.02); C318(1.08)  LDD1697  [24]
 LDCM0495  E2913 HEK-293T C92(1.21); C301(0.89); C189(1.00); C318(1.16)  LDD1698  [24]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C58(0.60)  LDD1702  [5]
 LDCM0625  F8 Ramos C92(1.15)  LDD2187  [25]
 LDCM0572  Fragment10 Ramos C92(0.75)  LDD2189  [25]
 LDCM0573  Fragment11 Ramos C92(0.33)  LDD2190  [25]
 LDCM0574  Fragment12 Ramos C92(0.64)  LDD2191  [25]
 LDCM0575  Fragment13 Ramos C92(0.97)  LDD2192  [25]
 LDCM0576  Fragment14 Ramos C92(0.68)  LDD2193  [25]
 LDCM0579  Fragment20 Ramos C92(0.36)  LDD2194  [25]
 LDCM0580  Fragment21 Ramos C92(0.92)  LDD2195  [25]
 LDCM0582  Fragment23 Ramos C92(0.99)  LDD2196  [25]
 LDCM0578  Fragment27 Ramos C92(1.03)  LDD2197  [25]
 LDCM0586  Fragment28 Ramos C92(0.87)  LDD2198  [25]
 LDCM0588  Fragment30 Ramos C92(1.01)  LDD2199  [25]
 LDCM0589  Fragment31 Ramos C92(0.86)  LDD2200  [25]
 LDCM0590  Fragment32 Ramos C92(0.75)  LDD2201  [25]
 LDCM0468  Fragment33 PaTu 8988t C92(0.71)  LDD1347  [6]
 LDCM0596  Fragment38 Ramos C92(0.99)  LDD2203  [25]
 LDCM0566  Fragment4 Ramos C92(0.63)  LDD2184  [25]
 LDCM0427  Fragment51 HCT 116 C301(0.54); C92(0.98)  LDD0744  [6]
 LDCM0610  Fragment52 Ramos C92(1.23)  LDD2204  [25]
 LDCM0614  Fragment56 Ramos C92(1.44)  LDD2205  [25]
 LDCM0569  Fragment7 Ramos C92(0.56)  LDD2186  [25]
 LDCM0571  Fragment9 Ramos C92(0.46)  LDD2188  [25]
 LDCM0107  IAA HeLa C92(0.00); C318(0.00); H298(0.00); H306(0.00)  LDD0221  [18]
 LDCM0022  KB02 HEK-293T C92(0.90); C301(1.00); C318(0.98); C189(0.95)  LDD1492  [24]
 LDCM0023  KB03 HEK-293T C92(0.97); C301(1.04); C318(0.98); C189(0.99)  LDD1497  [24]
 LDCM0024  KB05 G361 C241(2.60); C92(1.35)  LDD3311  [26]
 LDCM0109  NEM HeLa C92(0.00); H306(0.00); H298(0.00); C318(0.00)  LDD0223  [18]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C92(0.87)  LDD2099  [5]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C92(0.65)  LDD2100  [5]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C92(0.65)  LDD2104  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C92(0.58)  LDD2109  [5]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C92(1.12)  LDD2111  [5]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C92(0.69)  LDD2114  [5]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C92(0.42)  LDD2115  [5]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C92(0.56)  LDD2118  [5]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C92(0.33)  LDD2122  [5]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C92(0.32)  LDD2124  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C92(0.91)  LDD2125  [5]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C92(0.34)  LDD2126  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C92(1.13); C301(1.74)  LDD2127  [5]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C92(0.89)  LDD2128  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C92(0.83); C241(0.37)  LDD2136  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C92(1.11)  LDD2137  [5]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C92(2.00)  LDD1700  [5]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C92(0.63); C241(0.57)  LDD2141  [5]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C92(1.39)  LDD2145  [5]
 LDCM0627  NUDT7-COV-1 HEK-293T C92(4.00)  LDD2206  [27]
 LDCM0628  OTUB2-COV-1 HEK-293T C58(0.87); C92(0.77)  LDD2207  [27]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tyrosine-protein kinase Lyn (LYN) Tyr protein kinase family P07948
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067
Protein ERGIC-53 (LMAN1) . P49257

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
8 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
11 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
15 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
16 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
17 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
18 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
19 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
20 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
21 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
22 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
23 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
24 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
25 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
26 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
27 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.