Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C130  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 89 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03540  Heme oxygenase 2 (HMOX2) 45.9
 LDTP12135  Sialate O-acetylesterase (SIAE) 45.3
 LDTP02359  Heme oxygenase 1 (HMOX1) 30.1
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 23.3
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 20.7
 LDTP00697  Cytochrome b5 type B (CYB5B) 20.3
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 19.7
 LDTP02505  Lysosomal protective protein (CTSA) 19.2
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 18.9
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 18.4
 LDTP00907  Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D) 18.3
 LDTP00486  Cytochrome b-c1 complex subunit 8 (UQCRQ) 17.6
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 17.5
 LDTP02005  Lysosomal acid glucosylceramidase (GBA1) 17.1
 LDTP01982  NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) 17.1
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 16.9
 LDTP06477  Methylsterol monooxygenase 1 (MSMO1) 16.1
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 16.0
 LDTP06618  ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) 15.3
 LDTP01769  Dihydrofolate reductase (DHFR) 15.2
 LDTP10329  Ceramide synthase 2 (CERS2) 15.0
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 15.0
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 14.6
 LDTP15484  Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) 14.6
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 13.5
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 13.5
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 12.4
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 12.4
 LDTP07620  Peroxisomal N(1)-acetyl-spermine/spermidine oxidase (PAOX) 12.4
 LDTP08859  Polypeptide N-acetylgalactosaminyltransferase 4 (GALNT4) 12.0
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 11.9
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 11.4
 LDTP05476  3-ketodihydrosphingosine reductase (KDSR) 11.2
 LDTP02837  Beta-galactosidase (GLB1) 11.2
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 10.9
 LDTP00428  Tripeptidyl-peptidase 1 (TPP1) 10.7
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 10.3
 LDTP01613  Sphingosine-1-phosphate lyase 1 (SGPL1) 10.0
 LDTP08385  NADH dehydrogenase 1 alpha subcomplex subunit 11 (NDUFA11) 9.6
 LDTP12867  Very-long-chain enoyl-CoA reductase (TECR) 9.4
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 9.4
 LDTP17305  Glycosyltransferase 8 domain-containing protein 1 (GLT8D1) 9.2
 LDTP04437  Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) 8.9
 LDTP13154  E3 ubiquitin-protein ligase RNF14 (RNF14) 8.8
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 8.8
 LDTP10188  FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1) 8.8
 LDTP05905  Acid ceramidase (ASAH1) 8.8
 LDTP03912  Trifunctional enzyme subunit alpha, mitochondrial (HADHA) 8.7
 LDTP04286  DNA replication licensing factor MCM2 (MCM2) 8.6
 LDTP15480  Prenylcysteine oxidase-like (PCYOX1L) 8.6
 LDTP00988  Protein O-GlcNAcase (OGA) 8.6
 LDTP08790  Mitochondrial cardiolipin hydrolase (PLD6) 8.5
 LDTP02799  N-acetylglucosamine-6-sulfatase (GNS) 8.3
 LDTP06150  DNA replication licensing factor MCM6 (MCM6) 8.3
 LDTP03418  Proteasome subunit beta type-6 (PSMB6) 8.3
 LDTP09096  Carbohydrate sulfotransferase 14 (CHST14) 8.2
 LDTP15328  Dolichyldiphosphatase 1 (DOLPP1) 8.2
 LDTP11127  ADP-dependent glucokinase (ADPGK) 8.1
 LDTP02486  Lysosomal alpha-glucosidase (GAA) 8.1
 LDTP01773  Cytochrome c oxidase subunit 2 (MT-CO2) 8.0
 LDTP02254  ATP-dependent translocase ABCB1 (ABCB1) 7.9
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 7.9
 LDTP06787  Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) 7.9
 LDTP09088  Phospholipase A2 group XV (PLA2G15) 7.7
 LDTP08728  Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) 7.7
 LDTP05066  Signal peptidase complex catalytic subunit SEC11A (SEC11A) 7.6
 LDTP16040  Glyoxalase domain-containing protein 4 (GLOD4) 7.6
 LDTP12628  Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) 7.5
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 7.4
 LDTP02679  Prolyl 4-hydroxylase subunit alpha-1 (P4HA1) 7.4
 LDTP03854  Vitamin K-dependent gamma-carboxylase (GGCX) 7.4
 LDTP05632  Mitochondrial-processing peptidase subunit alpha (PMPCA) 7.3
 LDTP10550  Dehydrogenase/reductase SDR family member 1 (DHRS1) 7.3
 LDTP11273  N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) 7.3
 LDTP17247  5'-nucleotidase domain-containing protein 1 (NT5DC1) 7.1
 LDTP04634  Alpha-N-acetylglucosaminidase (NAGLU) 7.0
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 6.9
 LDTP09395  Signal peptide peptidase-like 2A (SPPL2A) 6.9
 LDTP07831  Transmembrane protein with metallophosphoesterase domain (TMPPE) 6.9
 LDTP01168  NADH dehydrogenase iron-sulfur protein 2, mitochondrial (NDUFS2) 6.7
 LDTP09155  Phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3) 6.7
 LDTP05862  NAD(P) transhydrogenase, mitochondrial (NNT) 6.6
 LDTP09256  Putative phospholipase B-like 2 (PLBD2) 6.6
 LDTP09396  Minor histocompatibility antigen H13 (HM13) 6.6
 LDTP00338  Lysosomal alpha-mannosidase (MAN2B1) 6.5
 LDTP10612  Lysophospholipid acyltransferase 7 (MBOAT7) 6.4
 LDTP07990  Heparan sulfate 2-O-sulfotransferase 1 (HS2ST1) 6.4
 LDTP14030  V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) 6.3
 LDTP12868  Endoplasmic reticulum aminopeptidase 1 (ERAP1) 6.3
Transporter and channel
Click to Show/Hide to Show 52 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 53.8
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 39.4
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 37.3
 LDTP15948  Transmembrane protein 126A (TMEM126A) 27.7
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 26.0
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 26.0
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 26.0
 LDTP08881  Transmembrane protein 199 (TMEM199) 23.6
 LDTP02215  Prosaposin (PSAP) 20.8
 LDTP11615  Protein tweety homolog 3 (TTYH3) 20.0
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 19.0
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 17.5
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 17.4
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 16.8
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 16.1
 LDTP14099  Mitochondrial import inner membrane translocase subunit Tim22 (TIMM22) 15.5
 LDTP07236  Protein GPR107 (GPR107) 14.9
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 13.5
 LDTP20002  Transmembrane protein 160 (TMEM160) 13.0
 LDTP18153  Major facilitator superfamily domain-containing protein 3 (MFSD3) 12.6
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 12.0
 LDTP00262  Acetyl-coenzyme A transporter 1 (SLC33A1) 10.9
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 10.2
 LDTP05900  Metaxin-1 (MTX1) 10.2
 LDTP09328  Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) 9.8
 LDTP00541  NPC intracellular cholesterol transporter 1 (NPC1) 9.8
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 9.4
 LDTP13983  Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) 9.1
 LDTP15648  BRI3-binding protein (BRI3BP) 8.6
 LDTP11213  Nucleoporin NDC1 (NDC1) 8.6
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 8.5
 LDTP01745  Putative lipid scramblase CLPTM1 (CLPTM1) 8.5
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 8.4
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 8.3
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 8.3
 LDTP16069  Peroxisomal membrane protein 2 (PXMP2) 8.2
 LDTP16190  Protein FAM8A1 (FAM8A1) 8.1
 LDTP00592  Surfeit locus protein 4 (SURF4) 8.1
 LDTP18459  StAR-related lipid transfer protein 7, mitochondrial (STARD7) 7.9
 LDTP14235  Mitochondrial carrier homolog 2 (MTCH2) 7.9
 LDTP06221  StAR-related lipid transfer protein 3 (STARD3) 7.7
 LDTP09288  Vang-like protein 1 (VANGL1) 7.3
 LDTP17641  Solute carrier family 35 member F2 (SLC35F2) 7.2
 LDTP03380  Stomatin (STOM) 7.2
 LDTP11245  Derlin-1 (DERL1) 7.1
 LDTP01542  Golgi SNAP receptor complex member 1 (GOSR1) 7.0
 LDTP11826  Sodium-dependent neutral amino acid transporter B(0)AT2 (SLC6A15) 7.0
 LDTP14200  Mitochondrial ornithine transporter 1 (SLC25A15) 6.5
 LDTP06308  Mitochondrial inner membrane protein OXA1L (OXA1L) 6.5
 LDTP07667  Transmembrane protein 205 (TMEM205) 6.5
 LDTP10499  Lipid scramblase CLPTM1L (CLPTM1L) 6.5
 LDTP06365  Transmembrane emp24 domain-containing protein 2 (TMED2) 6.4
Transcription factor
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10501  DnaJ homolog subfamily C member 1 (DNAJC1) 6.8
Other
Click to Show/Hide to Show 48 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 30.3
 LDTP16192  Mitochondrial fission process protein 1 (MTFP1) 24.4
 LDTP11076  Apolipoprotein L2 (APOL2) 22.6
 LDTP05160  Nucleobindin-2 (NUCB2) 21.9
 LDTP18883  Protein CEBPZOS (CEBPZOS) 20.7
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 20.7
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 20.0
 LDTP14458  Tetraspanin-6 (TSPAN6) 17.1
 LDTP05375  Nucleobindin-1 (NUCB1) 13.5
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 13.0
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 12.6
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 12.5
 LDTP18272  Transmembrane protein 209 (TMEM209) 12.4
 LDTP01522  Reticulon-3 (RTN3) 12.0
 LDTP10056  Protein FAM162A (FAM162A) 11.1
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 10.3
 LDTP13902  Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) 10.2
 LDTP01075  Protein CutA (CUTA) 10.2
 LDTP16080  Protein FAM114A2 (FAM114A2) 10.0
 LDTP05711  Nuclear inhibitor of protein phosphatase 1 (PPP1R8) 9.7
 LDTP14822  Splicing factor, suppressor of white-apricot homolog (SFSWAP) 9.3
 LDTP16006  Optic atrophy 3 protein (OPA3) 9.3
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 8.8
 LDTP12412  Reticulon-4 (RTN4) 8.4
 LDTP13086  Syntaxin-18 (STX18) 8.3
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 8.1
 LDTP08606  Nurim (NRM) 7.9
 LDTP01652  Centrosomal protein 43 (CEP43) 7.8
 LDTP18373  Thioredoxin-related transmembrane protein 4 (TMX4) 7.7
 LDTP05764  Calcium-binding and coiled-coil domain-containing protein 2 (CALCOCO2) 7.5
 LDTP16323  Signal recognition particle receptor subunit beta (SRPRB) 7.5
 LDTP19963  TraB domain-containing protein (TRABD) 7.4
 LDTP02124  Keratin, type I cytoskeletal 18 (KRT18) 7.3
 LDTP13633  U3 small nucleolar RNA-associated protein NOL7 (NOL7) 7.3
 LDTP15863  Large ribosomal subunit protein mL45 (MRPL45) 7.2
 LDTP07916  Protein MTSS 2 (MTSS2) 7.1
 LDTP11144  Endoplasmic reticulum resident protein 44 (ERP44) 7.0
 LDTP02927  Ganglioside GM2 activator (GM2A) 6.8
 LDTP07906  Mediator of RNA polymerase II transcription subunit 25 (MED25) 6.8
 LDTP01359  Dynactin subunit 3 (DCTN3) 6.7
 LDTP00859  Synaptogyrin-2 (SYNGR2) 6.7
 LDTP08689  Dyslexia-associated protein KIAA0319-like protein (KIAA0319L) 6.7
 LDTP07368  Tetratricopeptide repeat protein 19, mitochondrial (TTC19) 6.6
 LDTP14792  Small ribosomal subunit protein uS9m (MRPS9) 6.6
 LDTP13311  Poly(U)-binding-splicing factor PUF60 (PUF60) 6.5
 LDTP04682  RNA polymerase II elongation factor ELL (ELL) 6.5
 LDTP13797  HIG1 domain family member 1A, mitochondrial (HIGD1A) 6.5
 LDTP02297  Vimentin (VIM) 6.3

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587