Details of the Target

General Information of Target

Target ID LDTP09396
Target Name Minor histocompatibility antigen H13 (HM13)
Gene Name HM13
Gene ID 81502
Synonyms
H13; IMP1; PSL3; SPP; Minor histocompatibility antigen H13; EC 3.4.23.-; Intramembrane protease 1; IMP-1; IMPAS-1; hIMP1; Presenilin-like protein 3; Signal peptide peptidase
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MDSALSDPHNGSAEAGGPTNSTTRPPSTPEGIALAYGSLLLMALLPIFFGALRSVRCARG
KNASDMPETITSRDAARFPIIASCTLLGLYLFFKIFSQEYINLLLSMYFFVLGILALSHT
ISPFMNKFFPASFPNRQYQLLFTQGSGENKEEIINYEFDTKDLVCLGLSSIVGVWYLLRK
HWIANNLFGLAFSLNGVELLHLNNVSTGCILLGGLFIYDVFWVFGTNVMVTVAKSFEAPI
KLVFPQDLLEKGLEANNFAMLGLGDVVIPGIFIALLLRFDISLKKNTHTYFYTSFAAYIF
GLGLTIFIMHIFKHAQPALLYLVPACIGFPVLVALAKGEVTEMFSYEESNPKDPAAVTES
KEGTEASASKGLEKKEK
Target Bioclass
Enzyme
Family
Peptidase A22B family
Subcellular location
Endoplasmic reticulum membrane; Cell membrane
Function
Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides. May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein. Involved in the intramembrane cleavage of the integral membrane protein PSEN1. Cleaves the integral membrane protein XBP1 isoform 1 in a DERL1/RNF139-dependent manner. May play a role in graft rejection.
Uniprot ID
Q8TCT9
Ensemble ID
ENST00000340852.9
HGNC ID
HGNC:16435
ChEMBL ID
CHEMBL4523407

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 24 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.39  LDD0402  [2]
HDSF-alk
 Probe Info  		3.05  LDD0197  [3]
FBPP2
 Probe Info  		2.54  LDD0318  [4]
CHEMBL5175495
 Probe Info  		5.77  LDD0196  [5]
CY4
 Probe Info  		100.00  LDD0244  [6]
N1
 Probe Info  		100.00  LDD0242  [6]
TH211
 Probe Info  		Y346(5.65)  LDD0260  [7]
C-Sul
 Probe Info  		2.26  LDD0066  [8]
YN-1
 Probe Info  		100.00  LDD0444  [9]
YN-4
 Probe Info  		100.00  LDD0445  [9]
STPyne
 Probe Info  		K284(10.00); K61(7.66)  LDD0277  [10]
ONAyne
 Probe Info  		N.A.  LDD0273  [10]
OPA-S-S-alkyne
 Probe Info  		K61(1.69)  LDD3494  [11]
Alkylaryl probe 2
 Probe Info  		3.00  LDD0392  [12]
DBIA
 Probe Info  		C326(2.27)  LDD3310  [13]
SAHA-CA-4PAP
 Probe Info  		4.00  LDD0269  [14]
BTD
 Probe Info  		C57(1.21)  LDD2089  [15]
HPAP
 Probe Info  		3.29  LDD0064  [16]
EA-probe
 Probe Info  		N.A.  LDD0440  [17]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [18]
NHS
 Probe Info  		N.A.  LDD0010  [19]
1d-yne
 Probe Info  		N.A.  LDD0357  [20]
AOyne
 Probe Info  		15.00  LDD0443  [21]
NAIA_5
 Probe Info  		N.A.  LDD2223  [22]
PAL-AfBPP Probe
Click To Hide/Show 83 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DR-1
 Probe Info  		4.87  LDD0398  [23]
C004
 Probe Info  		5.46  LDD1714  [24]
C022
 Probe Info  		17.03  LDD1728  [24]
C040
 Probe Info  		10.27  LDD1740  [24]
C041
 Probe Info  		7.11  LDD1741  [24]
C049
 Probe Info  		5.74  LDD1747  [24]
C053
 Probe Info  		5.31  LDD1751  [24]
C056
 Probe Info  		18.25  LDD1753  [24]
C063
 Probe Info  		19.56  LDD1760  [24]
C070
 Probe Info  		11.08  LDD1766  [24]
C082
 Probe Info  		12.55  LDD1774  [24]
C087
 Probe Info  		13.74  LDD1779  [24]
C095
 Probe Info  		8.51  LDD1786  [24]
C100
 Probe Info  		10.85  LDD1789  [24]
C112
 Probe Info  		20.39  LDD1799  [24]
C130
 Probe Info  		6.59  LDD1812  [24]
C134
 Probe Info  		37.27  LDD1816  [24]
C135
 Probe Info  		13.83  LDD1817  [24]
C141
 Probe Info  		9.92  LDD1823  [24]
C143
 Probe Info  		33.13  LDD1825  [24]
C153
 Probe Info  		69.55  LDD1834  [24]
C159
 Probe Info  		10.78  LDD1839  [24]
C161
 Probe Info  		12.04  LDD1841  [24]
C163
 Probe Info  		5.94  LDD1843  [24]
C166
 Probe Info  		6.92  LDD1846  [24]
C169
 Probe Info  		29.86  LDD1849  [24]
C187
 Probe Info  		19.56  LDD1865  [24]
C218
 Probe Info  		12.91  LDD1892  [24]
C225
 Probe Info  		5.24  LDD1898  [24]
C226
 Probe Info  		8.34  LDD1899  [24]
C228
 Probe Info  		23.75  LDD1901  [24]
C229
 Probe Info  		9.25  LDD1902  [24]
C231
 Probe Info  		61.82  LDD1904  [24]
C232
 Probe Info  		61.82  LDD1905  [24]
C233
 Probe Info  		13.74  LDD1906  [24]
C234
 Probe Info  		33.13  LDD1907  [24]
C235
 Probe Info  		32.00  LDD1908  [24]
C238
 Probe Info  		20.11  LDD1911  [24]
C246
 Probe Info  		12.21  LDD1919  [24]
C252
 Probe Info  		28.84  LDD1925  [24]
C264
 Probe Info  		29.04  LDD1935  [24]
C265
 Probe Info  		20.68  LDD1936  [24]
C266
 Probe Info  		8.11  LDD1937  [24]
C270
 Probe Info  		7.31  LDD1940  [24]
C289
 Probe Info  		27.86  LDD1959  [24]
C293
 Probe Info  		30.06  LDD1963  [24]
C296
 Probe Info  		35.02  LDD1966  [24]
C299
 Probe Info  		23.92  LDD1968  [24]
C310
 Probe Info  		8.06  LDD1977  [24]
C314
 Probe Info  		24.08  LDD1981  [24]
C322
 Probe Info  		7.73  LDD1988  [24]
C338
 Probe Info  		15.45  LDD2001  [24]
C339
 Probe Info  		8.34  LDD2002  [24]
C348
 Probe Info  		12.91  LDD2009  [24]
C349
 Probe Info  		14.83  LDD2010  [24]
C350
 Probe Info  		39.67  LDD2011  [24]
C355
 Probe Info  		36.00  LDD2016  [24]
C356
 Probe Info  		9.38  LDD2017  [24]
C357
 Probe Info  		5.90  LDD2018  [24]
C362
 Probe Info  		66.72  LDD2023  [24]
C364
 Probe Info  		16.34  LDD2025  [24]
C373
 Probe Info  		7.11  LDD2033  [24]
C390
 Probe Info  		28.64  LDD2049  [24]
C403
 Probe Info  		24.25  LDD2061  [24]
C413
 Probe Info  		13.64  LDD2069  [24]
C419
 Probe Info  		9.78  LDD2074  [24]
C420
 Probe Info  		18.90  LDD2075  [24]
C426
 Probe Info  		27.67  LDD2081  [24]
C429
 Probe Info  		19.97  LDD2084  [24]
C431
 Probe Info  		30.27  LDD2086  [24]
FFF probe11
 Probe Info  		20.00  LDD0471  [25]
FFF probe13
 Probe Info  		20.00  LDD0475  [25]
FFF probe14
 Probe Info  		20.00  LDD0477  [25]
FFF probe2
 Probe Info  		20.00  LDD0463  [25]
FFF probe3
 Probe Info  		20.00  LDD0464  [25]
FFF probe4
 Probe Info  		20.00  LDD0466  [25]
JN0003
 Probe Info  		20.00  LDD0469  [25]
STS-1
 Probe Info  		N.A.  LDD0136  [26]
STS-2
 Probe Info  		N.A.  LDD0138  [26]
Staurosporine capture compound
 Probe Info  		3.00  LDD0083  [27]
Photocelecoxib
 Probe Info  		N.A.  LDD0019  [28]
Photoindomethacin
 Probe Info  		E68(0.00); I70(0.00)  LDD0155  [28]
OEA-DA
 Probe Info  		12.64  LDD0046  [29]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C57(0.53)  LDD2095  [15]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C57(0.43)  LDD2132  [15]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C57(0.81)  LDD2131  [15]
 LDCM0214  AC1 HEK-293T C326(0.93)  LDD1507  [30]
 LDCM0215  AC10 HEK-293T C326(0.89)  LDD1508  [30]
 LDCM0226  AC11 HEK-293T C326(0.90)  LDD1509  [30]
 LDCM0237  AC12 HEK-293T C326(0.93)  LDD1510  [30]
 LDCM0259  AC14 HEK-293T C326(1.00)  LDD1512  [30]
 LDCM0270  AC15 HEK-293T C326(0.95)  LDD1513  [30]
 LDCM0276  AC17 HEK-293T C326(0.91)  LDD1515  [30]
 LDCM0277  AC18 HEK-293T C326(0.83)  LDD1516  [30]
 LDCM0278  AC19 HEK-293T C326(0.91)  LDD1517  [30]
 LDCM0279  AC2 HEK-293T C326(0.95)  LDD1518  [30]
 LDCM0280  AC20 HEK-293T C326(0.81)  LDD1519  [30]
 LDCM0281  AC21 HEK-293T C326(0.89)  LDD1520  [30]
 LDCM0282  AC22 HEK-293T C326(0.95)  LDD1521  [30]
 LDCM0283  AC23 HEK-293T C326(0.89)  LDD1522  [30]
 LDCM0284  AC24 HEK-293T C326(0.95)  LDD1523  [30]
 LDCM0285  AC25 HEK-293T C326(0.88)  LDD1524  [30]
 LDCM0286  AC26 HEK-293T C326(0.91)  LDD1525  [30]
 LDCM0287  AC27 HEK-293T C326(0.86)  LDD1526  [30]
 LDCM0288  AC28 HEK-293T C326(0.97)  LDD1527  [30]
 LDCM0289  AC29 HEK-293T C326(0.85)  LDD1528  [30]
 LDCM0290  AC3 HEK-293T C326(0.96)  LDD1529  [30]
 LDCM0291  AC30 HEK-293T C326(0.86)  LDD1530  [30]
 LDCM0292  AC31 HEK-293T C326(0.93)  LDD1531  [30]
 LDCM0293  AC32 HEK-293T C326(0.94)  LDD1532  [30]
 LDCM0294  AC33 HEK-293T C326(0.86)  LDD1533  [30]
 LDCM0295  AC34 HEK-293T C326(0.95)  LDD1534  [30]
 LDCM0296  AC35 HEK-293T C326(0.92)  LDD1535  [30]
 LDCM0297  AC36 HEK-293T C326(0.79)  LDD1536  [30]
 LDCM0298  AC37 HEK-293T C326(0.85)  LDD1537  [30]
 LDCM0299  AC38 HEK-293T C326(0.92)  LDD1538  [30]
 LDCM0300  AC39 HEK-293T C326(0.90)  LDD1539  [30]
 LDCM0301  AC4 HEK-293T C326(0.98)  LDD1540  [30]
 LDCM0302  AC40 HEK-293T C326(1.05)  LDD1541  [30]
 LDCM0303  AC41 HEK-293T C326(0.92)  LDD1542  [30]
 LDCM0304  AC42 HEK-293T C326(0.81)  LDD1543  [30]
 LDCM0305  AC43 HEK-293T C326(0.81)  LDD1544  [30]
 LDCM0306  AC44 HEK-293T C326(0.89)  LDD1545  [30]
 LDCM0307  AC45 HEK-293T C326(0.88)  LDD1546  [30]
 LDCM0308  AC46 HEK-293T C326(0.95)  LDD1547  [30]
 LDCM0309  AC47 HEK-293T C326(1.02)  LDD1548  [30]
 LDCM0310  AC48 HEK-293T C326(1.03)  LDD1549  [30]
 LDCM0311  AC49 HEK-293T C326(0.90)  LDD1550  [30]
 LDCM0312  AC5 HEK-293T C326(0.92)  LDD1551  [30]
 LDCM0313  AC50 HEK-293T C326(0.84)  LDD1552  [30]
 LDCM0314  AC51 HEK-293T C326(0.85)  LDD1553  [30]
 LDCM0315  AC52 HEK-293T C326(0.86)  LDD1554  [30]
 LDCM0316  AC53 HEK-293T C326(0.86)  LDD1555  [30]
 LDCM0317  AC54 HEK-293T C326(0.95)  LDD1556  [30]
 LDCM0318  AC55 HEK-293T C326(1.04)  LDD1557  [30]
 LDCM0319  AC56 HEK-293T C326(1.06)  LDD1558  [30]
 LDCM0320  AC57 HEK-293T C326(1.03)  LDD1559  [30]
 LDCM0321  AC58 HEK-293T C326(1.14)  LDD1560  [30]
 LDCM0322  AC59 HEK-293T C326(1.01)  LDD1561  [30]
 LDCM0323  AC6 HEK-293T C326(1.00)  LDD1562  [30]
 LDCM0324  AC60 HEK-293T C326(0.99)  LDD1563  [30]
 LDCM0325  AC61 HEK-293T C326(1.01)  LDD1564  [30]
 LDCM0326  AC62 HEK-293T C326(1.04)  LDD1565  [30]
 LDCM0327  AC63 HEK-293T C326(1.09)  LDD1566  [30]
 LDCM0328  AC64 HEK-293T C326(1.01)  LDD1567  [30]
 LDCM0334  AC7 HEK-293T C326(0.99)  LDD1568  [30]
 LDCM0345  AC8 HEK-293T C326(1.03)  LDD1569  [30]
 LDCM0248  AKOS034007472 HEK-293T C326(0.85)  LDD1511  [30]
 LDCM0356  AKOS034007680 HEK-293T C326(0.95)  LDD1570  [30]
 LDCM0275  AKOS034007705 HEK-293T C326(1.02)  LDD1514  [30]
 LDCM0156  Aniline NCI-H1299 11.81  LDD0403  [2]
 LDCM0498  BS-3668 MDA-MB-231 C57(0.52)  LDD2091  [15]
 LDCM0367  CL1 HEK-293T C326(1.34)  LDD1571  [30]
 LDCM0368  CL10 HEK-293T C326(1.74)  LDD1572  [30]
 LDCM0369  CL100 HEK-293T C326(1.04)  LDD1573  [30]
 LDCM0370  CL101 HEK-293T C326(1.06)  LDD1574  [30]
 LDCM0371  CL102 HEK-293T C326(1.07)  LDD1575  [30]
 LDCM0372  CL103 HEK-293T C326(1.02)  LDD1576  [30]
 LDCM0373  CL104 HEK-293T C326(1.10)  LDD1577  [30]
 LDCM0374  CL105 HEK-293T C326(1.01)  LDD1578  [30]
 LDCM0375  CL106 HEK-293T C326(1.06)  LDD1579  [30]
 LDCM0376  CL107 HEK-293T C326(1.04)  LDD1580  [30]
 LDCM0377  CL108 HEK-293T C326(0.82)  LDD1581  [30]
 LDCM0378  CL109 HEK-293T C326(1.03)  LDD1582  [30]
 LDCM0379  CL11 HEK-293T C326(1.05)  LDD1583  [30]
 LDCM0380  CL110 HEK-293T C326(1.22)  LDD1584  [30]
 LDCM0381  CL111 HEK-293T C326(1.06)  LDD1585  [30]
 LDCM0382  CL112 HEK-293T C326(0.84)  LDD1586  [30]
 LDCM0383  CL113 HEK-293T C326(1.01)  LDD1587  [30]
 LDCM0384  CL114 HEK-293T C326(1.19)  LDD1588  [30]
 LDCM0385  CL115 HEK-293T C326(0.96)  LDD1589  [30]
 LDCM0386  CL116 HEK-293T C326(0.81)  LDD1590  [30]
 LDCM0387  CL117 HEK-293T C326(0.91)  LDD1591  [30]
 LDCM0388  CL118 HEK-293T C326(0.93)  LDD1592  [30]
 LDCM0389  CL119 HEK-293T C326(1.05)  LDD1593  [30]
 LDCM0390  CL12 HEK-293T C326(1.25)  LDD1594  [30]
 LDCM0391  CL120 HEK-293T C326(0.97)  LDD1595  [30]
 LDCM0392  CL121 HEK-293T C326(0.95)  LDD1596  [30]
 LDCM0393  CL122 HEK-293T C326(1.10)  LDD1597  [30]
 LDCM0394  CL123 HEK-293T C326(1.32)  LDD1598  [30]
 LDCM0395  CL124 HEK-293T C326(0.88)  LDD1599  [30]
 LDCM0396  CL125 HEK-293T C326(1.07)  LDD1600  [30]
 LDCM0397  CL126 HEK-293T C326(1.20)  LDD1601  [30]
 LDCM0398  CL127 HEK-293T C326(1.08)  LDD1602  [30]
 LDCM0399  CL128 HEK-293T C326(1.10)  LDD1603  [30]
 LDCM0400  CL13 HEK-293T C326(1.22)  LDD1604  [30]
 LDCM0401  CL14 HEK-293T C326(1.10)  LDD1605  [30]
 LDCM0402  CL15 HEK-293T C326(1.39)  LDD1606  [30]
 LDCM0403  CL16 HEK-293T C326(0.98)  LDD1607  [30]
 LDCM0404  CL17 HEK-293T C326(1.42)  LDD1608  [30]
 LDCM0405  CL18 HEK-293T C326(1.08)  LDD1609  [30]
 LDCM0406  CL19 HEK-293T C326(1.00)  LDD1610  [30]
 LDCM0407  CL2 HEK-293T C326(1.12)  LDD1611  [30]
 LDCM0408  CL20 HEK-293T C326(1.10)  LDD1612  [30]
 LDCM0409  CL21 HEK-293T C326(1.36)  LDD1613  [30]
 LDCM0410  CL22 HEK-293T C326(1.03)  LDD1614  [30]
 LDCM0411  CL23 HEK-293T C326(0.99)  LDD1615  [30]
 LDCM0412  CL24 HEK-293T C326(1.13)  LDD1616  [30]
 LDCM0413  CL25 HEK-293T C326(1.49)  LDD1617  [30]
 LDCM0414  CL26 HEK-293T C326(1.02)  LDD1618  [30]
 LDCM0415  CL27 HEK-293T C326(1.06)  LDD1619  [30]
 LDCM0416  CL28 HEK-293T C326(1.03)  LDD1620  [30]
 LDCM0417  CL29 HEK-293T C326(0.94)  LDD1621  [30]
 LDCM0418  CL3 HEK-293T C326(1.26)  LDD1622  [30]
 LDCM0419  CL30 HEK-293T C326(0.99)  LDD1623  [30]
 LDCM0420  CL31 HEK-293T C326(0.97)  LDD1624  [30]
 LDCM0421  CL32 HEK-293T C326(0.92)  LDD1625  [30]
 LDCM0422  CL33 HEK-293T C326(1.67)  LDD1626  [30]
 LDCM0423  CL34 HEK-293T C326(1.11)  LDD1627  [30]
 LDCM0424  CL35 HEK-293T C326(0.90)  LDD1628  [30]
 LDCM0425  CL36 HEK-293T C326(1.13)  LDD1629  [30]
 LDCM0426  CL37 HEK-293T C326(1.35)  LDD1630  [30]
 LDCM0428  CL39 HEK-293T C326(0.98)  LDD1632  [30]
 LDCM0429  CL4 HEK-293T C326(1.17)  LDD1633  [30]
 LDCM0430  CL40 HEK-293T C326(0.82)  LDD1634  [30]
 LDCM0431  CL41 HEK-293T C326(0.94)  LDD1635  [30]
 LDCM0432  CL42 HEK-293T C326(0.96)  LDD1636  [30]
 LDCM0433  CL43 HEK-293T C326(1.03)  LDD1637  [30]
 LDCM0434  CL44 HEK-293T C326(0.86)  LDD1638  [30]
 LDCM0435  CL45 HEK-293T C326(0.91)  LDD1639  [30]
 LDCM0436  CL46 HEK-293T C326(0.94)  LDD1640  [30]
 LDCM0437  CL47 HEK-293T C326(0.92)  LDD1641  [30]
 LDCM0438  CL48 HEK-293T C326(1.08)  LDD1642  [30]
 LDCM0439  CL49 HEK-293T C326(1.45)  LDD1643  [30]
 LDCM0440  CL5 HEK-293T C326(1.13)  LDD1644  [30]
 LDCM0441  CL50 HEK-293T C326(1.12)  LDD1645  [30]
 LDCM0443  CL52 HEK-293T C326(0.93)  LDD1646  [30]
 LDCM0444  CL53 HEK-293T C326(1.36)  LDD1647  [30]
 LDCM0445  CL54 HEK-293T C326(1.53)  LDD1648  [30]
 LDCM0446  CL55 HEK-293T C326(1.00)  LDD1649  [30]
 LDCM0447  CL56 HEK-293T C326(1.04)  LDD1650  [30]
 LDCM0448  CL57 HEK-293T C326(1.08)  LDD1651  [30]
 LDCM0449  CL58 HEK-293T C326(1.07)  LDD1652  [30]
 LDCM0450  CL59 HEK-293T C326(0.94)  LDD1653  [30]
 LDCM0451  CL6 HEK-293T C326(1.35)  LDD1654  [30]
 LDCM0452  CL60 HEK-293T C326(1.07)  LDD1655  [30]
 LDCM0453  CL61 HEK-293T C326(1.17)  LDD1656  [30]
 LDCM0454  CL62 HEK-293T C326(0.97)  LDD1657  [30]
 LDCM0455  CL63 HEK-293T C326(0.99)  LDD1658  [30]
 LDCM0456  CL64 HEK-293T C326(1.19)  LDD1659  [30]
 LDCM0457  CL65 HEK-293T C326(0.97)  LDD1660  [30]
 LDCM0458  CL66 HEK-293T C326(0.93)  LDD1661  [30]
 LDCM0459  CL67 HEK-293T C326(0.98)  LDD1662  [30]
 LDCM0460  CL68 HEK-293T C326(0.96)  LDD1663  [30]
 LDCM0461  CL69 HEK-293T C326(1.03)  LDD1664  [30]
 LDCM0462  CL7 HEK-293T C326(0.94)  LDD1665  [30]
 LDCM0463  CL70 HEK-293T C326(1.01)  LDD1666  [30]
 LDCM0464  CL71 HEK-293T C326(0.93)  LDD1667  [30]
 LDCM0465  CL72 HEK-293T C326(1.16)  LDD1668  [30]
 LDCM0466  CL73 HEK-293T C326(1.29)  LDD1669  [30]
 LDCM0467  CL74 HEK-293T C326(0.95)  LDD1670  [30]
 LDCM0469  CL76 HEK-293T C326(1.10)  LDD1672  [30]
 LDCM0470  CL77 HEK-293T C326(1.02)  LDD1673  [30]
 LDCM0471  CL78 HEK-293T C326(0.88)  LDD1674  [30]
 LDCM0472  CL79 HEK-293T C326(0.96)  LDD1675  [30]
 LDCM0473  CL8 HEK-293T C326(2.86)  LDD1676  [30]
 LDCM0474  CL80 HEK-293T C326(0.84)  LDD1677  [30]
 LDCM0475  CL81 HEK-293T C326(0.89)  LDD1678  [30]
 LDCM0476  CL82 HEK-293T C326(0.91)  LDD1679  [30]
 LDCM0477  CL83 HEK-293T C326(1.12)  LDD1680  [30]
 LDCM0478  CL84 HEK-293T C326(1.23)  LDD1681  [30]
 LDCM0479  CL85 HEK-293T C326(1.31)  LDD1682  [30]
 LDCM0480  CL86 HEK-293T C326(1.33)  LDD1683  [30]
 LDCM0481  CL87 HEK-293T C326(1.38)  LDD1684  [30]
 LDCM0482  CL88 HEK-293T C326(1.16)  LDD1685  [30]
 LDCM0483  CL89 HEK-293T C326(1.19)  LDD1686  [30]
 LDCM0484  CL9 HEK-293T C326(1.07)  LDD1687  [30]
 LDCM0485  CL90 HEK-293T C326(2.05)  LDD1688  [30]
 LDCM0486  CL91 HEK-293T C326(1.14)  LDD1689  [30]
 LDCM0487  CL92 HEK-293T C326(1.17)  LDD1690  [30]
 LDCM0488  CL93 HEK-293T C326(1.36)  LDD1691  [30]
 LDCM0489  CL94 HEK-293T C326(1.01)  LDD1692  [30]
 LDCM0490  CL95 HEK-293T C326(1.57)  LDD1693  [30]
 LDCM0491  CL96 HEK-293T C326(1.55)  LDD1694  [30]
 LDCM0492  CL97 HEK-293T C326(1.18)  LDD1695  [30]
 LDCM0493  CL98 HEK-293T C326(1.12)  LDD1696  [30]
 LDCM0494  CL99 HEK-293T C326(1.00)  LDD1697  [30]
 LDCM0495  E2913 HEK-293T C326(1.03)  LDD1698  [30]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [17]
 LDCM0625  F8 Ramos C326(1.11)  LDD2187  [31]
 LDCM0573  Fragment11 Ramos C326(1.18)  LDD2190  [31]
 LDCM0586  Fragment28 Ramos C326(2.83)  LDD2198  [31]
 LDCM0468  Fragment33 HEK-293T C326(1.06)  LDD1671  [30]
 LDCM0566  Fragment4 Ramos C326(1.54)  LDD2184  [31]
 LDCM0427  Fragment51 HEK-293T C326(1.00)  LDD1631  [30]
 LDCM0569  Fragment7 Ramos C326(5.38)  LDD2186  [31]
 LDCM0022  KB02 HEK-293T C326(0.95)  LDD1492  [30]
 LDCM0023  KB03 HEK-293T C326(0.91)  LDD1497  [30]
 LDCM0024  KB05 COLO792 C326(2.27)  LDD3310  [13]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C57(0.75)  LDD2121  [15]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C57(1.21)  LDD2089  [15]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C57(8.05)  LDD2090  [15]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C57(5.41)  LDD2094  [15]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C57(0.12)  LDD2096  [15]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C57(1.26)  LDD2104  [15]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C57(0.48)  LDD2107  [15]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C57(0.28)  LDD2108  [15]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C57(1.00)  LDD2109  [15]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C57(0.31)  LDD2116  [15]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C57(0.23)  LDD2118  [15]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C57(0.69)  LDD2120  [15]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C57(0.24)  LDD2122  [15]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C57(0.20)  LDD2124  [15]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C57(0.20)  LDD2126  [15]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C57(0.17)  LDD2128  [15]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C57(0.68)  LDD2140  [15]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C57(0.38)  LDD2141  [15]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C57(0.24)  LDD2143  [15]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C57(0.49)  LDD2146  [15]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C57(0.24)  LDD2149  [15]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C57(0.34)  LDD2150  [15]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C57(0.71)  LDD2151  [15]
 LDCM0014  Panhematin hPBMC 3.29  LDD0064  [16]
 LDCM0099  Phenelzine MDA-MB-231 3.00  LDD0392  [12]
 LDCM0096  SAHA K562 4.00  LDD0269  [14]
 LDCM0019  Staurosporine Hep-G2 3.00  LDD0083  [27]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein disulfide-isomerase (P4HB) Protein disulfide isomerase family P07237
E3 ubiquitin-protein ligase RNF139 (RNF139) . Q8WU17
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Derlin-1 (DERL1) Derlin family Q9BUN8
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Theophylline Small molecular drug DB00277

References

1 Labeling Preferences of Diazirines with Protein Biomolecules. J Am Chem Soc. 2021 May 5;143(17):6691-6700. doi: 10.1021/jacs.1c02509. Epub 2021 Apr 20.
Mass spectrometry data entry: PXD025140
2 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
3 Fatty Acyl Sulfonyl Fluoride as an Activity-Based Probe for Profiling Fatty Acid-Associated Proteins in Living Cells. Chembiochem. 2022 Feb 16;23(4):e202100628. doi: 10.1002/cbic.202100628. Epub 2021 Dec 30.
4 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
5 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
6 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
7 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
8 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
9 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
10 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
11 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
12 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
13 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
14 Streamlined Target Deconvolution Approach Utilizing a Single Photoreactive Chloroalkane Capture Tag. ACS Chem Biol. 2021 Feb 19;16(2):404-413. doi: 10.1021/acschembio.0c00987. Epub 2021 Feb 5.
15 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
16 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
17 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
18 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
19 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
20 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
21 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
22 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
23 Quantitative Proteomics Reveals Cellular Off-Targets of a DDR1 Inhibitor. ACS Med Chem Lett. 2020 Feb 5;11(4):535-540. doi: 10.1021/acsmedchemlett.9b00658. eCollection 2020 Apr 9.
24 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
25 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
26 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
27 Comprehensive identification of staurosporine-binding kinases in the hepatocyte cell line HepG2 using Capture Compound Mass Spectrometry (CCMS). J Proteome Res. 2010 Feb 5;9(2):806-17. doi: 10.1021/pr9007333.
28 Small Molecule Interactome Mapping by Photoaffinity Labeling Reveals Binding Site Hotspots for the NSAIDs. J Am Chem Soc. 2018 Mar 28;140(12):4259-4268. doi: 10.1021/jacs.7b11639. Epub 2018 Mar 15.
Mass spectrometry data entry: PXD007094
29 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
30 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
31 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578