Details of the Probe

General Information of Probe

Probe ID
LDPC0497
Probe Name
C266
Synonyms
Z3433407863
Probe Type
PAL-AfBPP Probe
Structure
2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 335.4
Lipid-water partition coefficient (xlogp) 3.3
Rotatable Bond Count (rotbonds) 7
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 4
Chemical Identifiers
Formula
C19H21N5O
IUPAC Name
N-[2-(3-but-3-ynyldiazirin-3-yl)ethyl]-3-cyclopropyl-5-methylimidazo[1,5-a]pyridine-6-carboxamide
Canonical SMILES
CC1=C(C=CC2=CN=C(N12)C3CC3)C(=O)NCCC4(N=N4)CCC#C
InChI
InChI=1S/C19H21N5O/c1-3-4-9-19(22-23-19)10-11-20-18(25)16-8-7-15-12-21-17(14-5-6-14)24(15)13(16)2/h1,7-8,12,14H,4-6,9-11H2,2H3,(H,20,25)
InChIKey
RYGGBBVEQZQBSH-UHFFFAOYSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

43 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Acireductone dioxygenase (ADI1) LDTP11268 8.06  LDD1937 
Adenosine deaminase (ADA) LDTP01803 10.56  LDD1937 
Adenosine kinase (ADK) LDTP04689 10.20  LDD1937 
Asparagine synthetase [glutamine-hydrolyzing] (ASNS) LDTP02264 10.34  LDD1937 
ATP-dependent translocase ABCB1 (ABCB1) LDTP02254 7.67  LDD1937 
ATPase family gene 2 protein homolog A (AFG2A) LDTP09044 9.06  LDD1937 
CAAX prenyl protease 1 homolog (ZMPSTE24) LDTP01328 18.13  LDD1937 
Ceramide glucosyltransferase (UGCG) LDTP06617 14.32  LDD1937 
Cytochrome b5 type B (CYB5B) LDTP00697 8.75  LDD1937 
Cytochrome c oxidase subunit 6B1 (COX6B1) LDTP02748 12.73  LDD1937 
Delta(24)-sterol reductase (DHCR24) LDTP06375 8.17  LDD1937 
DNA-directed RNA polymerase I subunit RPA43 (POLR1F) LDTP14904 8.51  LDD1937 
Endoplasmic reticulum aminopeptidase 1 (ERAP1) LDTP12868 8.46  LDD1937 
Endoplasmic reticulum transmembrane helix translocase (ATP13A1) LDTP12279 7.57  LDD1937 
Epimerase family protein SDR39U1 (SDR39U1) LDTP16070 7.73  LDD1937 
FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1) LDTP10188 8.63  LDD1937 
Geranylgeranyl transferase type-2 subunit beta (RABGGTB) LDTP04569 7.89  LDD1937 
Glycerol-3-phosphate phosphatase (PGP) LDTP00089 7.84  LDD1937 
Heme oxygenase 1 (HMOX1) LDTP02359 9.65  LDD1937 
Heme oxygenase 2 (HMOX2) LDTP03540 11.63  LDD1937 
Holocytochrome c-type synthase (HCCS) LDTP04581 20.39  LDD1937 
Lanosterol 14-alpha demethylase (CYP51A1) LDTP06648 11.63  LDD1937 
Leucine--tRNA ligase, cytoplasmic (LARS1) LDTP13056 7.73  LDD1937 
Minor histocompatibility antigen H13 (HM13) LDTP09396 8.11  LDD1937 
Mitochondrial intermediate peptidase (MIPEP) LDTP10981 7.67  LDD1937 
Mitochondrial-processing peptidase subunit alpha (PMPCA) LDTP05632 10.63  LDD1937 
Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1) LDTP06307 8.75  LDD1937 
Phospholipase A2 group XV (PLA2G15) LDTP09088 7.89  LDD1937 
Prenylcysteine oxidase 1 (PCYOX1) LDTP13282 11.39  LDD1937 
Prolyl endopeptidase (PREP) LDTP04163 20.39  LDD1937 
Prolyl endopeptidase-like (PREPL) LDTP06849 8.57  LDD1937 
Prostaglandin E synthase 2 (PTGES2) LDTP12040 10.56  LDD1937 
Protein arginine N-methyltransferase 9 (PRMT9) LDTP07525 10.13  LDD1937 
Protein-S-isoprenylcysteine O-methyltransferase (ICMT) LDTP01039 9.99  LDD1937 
Puromycin-sensitive aminopeptidase (NPEPPS) LDTP04712 10.93  LDD1937 
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) LDTP05917 8.57  LDD1937 
S-methyl-5'-thioadenosine phosphorylase (MTAP) LDTP05758 10.48  LDD1937 
Secernin-3 (SCRN3) LDTP17022 9.00  LDD1937 
Serine/threonine-protein kinase ULK3 (ULK3) LDTP07577 8.63  LDD1937 
Serum paraoxonase/arylesterase 2 (PON2) LDTP06333 17.15  LDD1937 
Signal peptidase complex catalytic subunit SEC11A (SEC11A) LDTP05066 7.57  LDD1937 
Sterol O-acyltransferase 1 (SOAT1) LDTP03769 9.85  LDD1937 
Threonine--tRNA ligase, mitochondrial (TARS2) LDTP11319 9.92  LDD1937 
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⏷ Show the Full List of 43 Enzyme
31 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
AP-1 complex subunit beta-1 (AP1B1) LDTP05625 7.73  LDD1937 
Cytochrome c oxidase assembly protein COX18, mitochondrial (COX18) LDTP08981 9.25  LDD1937 
Gasdermin-E (GSDME) LDTP00970 9.13  LDD1937 
Membrane-associated progesterone receptor component 1 (PGRMC1) LDTP00235 8.34  LDD1937 
Membrane-associated progesterone receptor component 2 (PGRMC2) LDTP00562 19.84  LDD1937 
Metaxin-1 (MTX1) LDTP05900 7.62  LDD1937 
Metaxin-2 (MTX2) LDTP01217 10.63  LDD1937 
Mitochondrial import inner membrane translocase subunit Tim10 (TIMM10) LDTP04956 10.48  LDD1937 
Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) LDTP10913 15.78  LDD1937 
Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) LDTP01059 17.75  LDD1937 
Mitochondrial import inner membrane translocase subunit Tim22 (TIMM22) LDTP14099 9.32  LDD1937 
Mitochondrial ornithine transporter 1 (SLC25A15) LDTP14200 8.34  LDD1937 
Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) LDTP07885 10.93  LDD1937 
Mpv17-like protein 2 (MPV17L2) LDTP14952 23.10  LDD1937 
Peroxisomal membrane protein 2 (PXMP2) LDTP16069 8.82  LDD1937 
Protein GPR107 (GPR107) LDTP07236 8.11  LDD1937 
Reticulon-1 (RTN1) LDTP06633 7.84  LDD1937 
Scavenger receptor class B member 1 (SCARB1) LDTP09547 11.16  LDD1937 
Sigma non-opioid intracellular receptor 1 (SIGMAR1) LDTP10958 10.63  LDD1937 
Solute carrier family 25 member 32 (SLC25A32) LDTP11813 8.40  LDD1937 
Solute carrier family 25 member 33 (SLC25A33) LDTP11162 10.78  LDD1937 
Sorting nexin-19 (SNX19) LDTP09788 8.28  LDD1937 
Sugar transporter SWEET1 (SLC50A1) LDTP11136 14.52  LDD1937 
Translocator protein (TSPO) LDTP03546 8.75  LDD1937 
Translocon-associated protein subunit alpha (SSR1) LDTP04033 9.00  LDD1937 
Transmembrane protein 126A (TMEM126A) LDTP15948 17.27  LDD1937 
Transmembrane protein 160 (TMEM160) LDTP20002 15.78  LDD1937 
Transmembrane protein 199 (TMEM199) LDTP08881 21.56  LDD1937 
Transmembrane protein 201 (TMEM201) LDTP07058 8.17  LDD1937 
Voltage-dependent anion-selective channel protein 1 (VDAC1) LDTP03132 12.64  LDD1937 
Voltage-dependent anion-selective channel protein 3 (VDAC3) LDTP13824 7.57  LDD1937 
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⏷ Show the Full List of 31 Transporter and channel
1 Transcription factor Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Forkhead box protein O3 (FOXO3) LDTP00791 8.51  LDD1937 
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30 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Angiomotin (AMOT) LDTP06868 8.22  LDD1937 
Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) LDTP08364 9.19  LDD1937 
Apolipoprotein L2 (APOL2) LDTP11076 23.92  LDD1937 
Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) LDTP13755 12.30  LDD1937 
Bromodomain-containing protein 7 (BRD7) LDTP12369 9.92  LDD1937 
Clustered mitochondria protein homolog (CLUH) LDTP14486 10.70  LDD1937 
Coiled-coil domain-containing protein 97 (CCDC97) LDTP19860 12.47  LDD1937 
Crk-like protein (CRKL) LDTP04092 9.65  LDD1937 
Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) LDTP13902 7.89  LDD1937 
HAUS augmin-like complex subunit 4 (HAUS4) LDTP11978 11.47  LDD1937 
Heme-binding protein 1 (HEBP1) LDTP16078 7.94  LDD1937 
Integrator complex subunit 3 (INTS3) LDTP07333 13.36  LDD1937 
Leucine zipper putative tumor suppressor 2 (LZTS2) LDTP11115 8.57  LDD1937 
Lipid droplet-regulating VLDL assembly factor AUP1 (AUP1) LDTP14217 8.88  LDD1937 
Membralin (TMEM259) LDTP14939 9.25  LDD1937 
Mitochondrial fission process protein 1 (MTFP1) LDTP16192 10.78  LDD1937 
Mitochondrial import receptor subunit TOM22 homolog (TOMM22) LDTP12565 15.89  LDD1937 
Muskelin (MKLN1) LDTP13525 7.94  LDD1937 
Neuferricin (CYB5D2) LDTP15623 14.42  LDD1937 
NFU1 iron-sulfur cluster scaffold homolog, mitochondrial (NFU1) LDTP13622 13.09  LDD1937 
Peroxisomal targeting signal 1 receptor (PEX5) LDTP04369 7.57  LDD1937 
Programmed cell death protein 4 (PDCD4) LDTP06881 10.48  LDD1937 
Proteasome assembly chaperone 1 (PSMG1) LDTP01608 14.42  LDD1937 
Protein Smaug homolog 2 (SAMD4B) LDTP07042 11.47  LDD1937 
Protein unc-119 homolog B (UNC119B) LDTP00105 12.04  LDD1937 
Splicing factor ESS-2 homolog (ESS2) LDTP10214 8.06  LDD1937 
Tetratricopeptide repeat protein 38 (TTC38) LDTP19372 22.47  LDD1937 
Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) LDTP15067 12.91  LDD1937 
Uncharacterized protein C15orf39 (C15orf39) LDTP17481 8.82  LDD1937 
Uncharacterized protein C1orf122 (C1orf122) LDTP19568 7.78  LDD1937 
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⏷ Show the Full List of 30 Other

Full Information of The Labelling Profiles of This Probe

Quantification: AfBPP Probe vs Negative Probe
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
Probe:50uM; negative probe:50uM
Quantitative Method
TMT
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Peripheral blood
Disease Model
Normal
Model Name
Human normal cells (HEK-293T)
Note
Negative probe:C#CCCC1(CCC(NC)=O)N=N1
Interaction Atlas ID
 LDD1937 
Download The Altas

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587