Details of the Target

General Information of Target

Target ID LDTP06881
Target Name Programmed cell death protein 4 (PDCD4)
Gene Name PDCD4
Gene ID 27250
Synonyms
H731; Programmed cell death protein 4; Neoplastic transformation inhibitor protein; Nuclear antigen H731-like; Protein 197/15a
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDVENEQILNVNPADPDNLSDSLFSGDEENAGTEEIKNEINGNWISASSINEARINAKAK
RRLRKNSSRDSGRGDSVSDSGSDALRSGLTVPTSPKGRLLDRRSRSGKGRGLPKKGGAGG
KGVWGTPGQVYDVEEVDVKDPNYDDDQENCVYETVVLPLDERAFEKTLTPIIQEYFEHGD
TNEVAEMLRDLNLGEMKSGVPVLAVSLALEGKASHREMTSKLLSDLCGTVMSTTDVEKSF
DKLLKDLPELALDTPRAPQLVGQFIARAVGDGILCNTYIDSYKGTVDCVQARAALDKATV
LLSMSKGGKRKDSVWGSGGGQQSVNHLVKEIDMLLKEYLLSGDISEAEHCLKELEVPHFH
HELVYEAIIMVLESTGESTFKMILDLLKSLWKSSTITVDQMKRGYERIYNEIPDINLDVP
HSYSVLERFVEECFQAGIISKQLRDLCPSRGRKRFVSEGDGGRLKPESY
Target Bioclass
Other
Family
PDCD4 family
Subcellular location
Nucleus
Function
Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA.
Uniprot ID
Q53EL6
Ensemble ID
ENST00000280154.12
HGNC ID
HGNC:8763
ChEMBL ID
CHEMBL1781868

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HSC4 SNV: p.D2V DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 26 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
TH211
 Probe Info  		Y423(13.65)  LDD0260  [2]
AZ-9
 Probe Info  		D287(0.91); D75(10.00)  LDD2208  [3]
Probe 1
 Probe Info  		Y131(7.92); Y175(9.28); Y409(6.25)  LDD3495  [4]
AHL-Pu-1
 Probe Info  		C275(2.86); C150(11.15)  LDD0168  [5]
DBIA
 Probe Info  		C288(0.85)  LDD0078  [6]
W1
 Probe Info  		C275(0.55)  LDD0239  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C275(0.00); C350(0.00); C433(0.00); C288(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		C275(0.00); C350(0.00); C433(0.00); C288(0.00)  LDD0036  [8]
Lodoacetamide azide
 Probe Info  		C275(0.00); C350(0.00); C288(0.00); C227(0.00)  LDD0037  [8]
JW-RF-010
 Probe Info  		C227(0.00); C288(0.00); C433(0.00)  LDD0026  [9]
TFBX
 Probe Info  		C227(0.00); C447(0.00); C433(0.00)  LDD0027  [9]
WYneN
 Probe Info  		N.A.  LDD0021  [10]
WYneO
 Probe Info  		N.A.  LDD0022  [10]
1d-yne
 Probe Info  		N.A.  LDD0356  [11]
Compound 10
 Probe Info  		N.A.  LDD2216  [12]
ENE
 Probe Info  		C288(0.00); C275(0.00)  LDD0006  [10]
IPM
 Probe Info  		C288(0.00); C275(0.00)  LDD0005  [10]
VSF
 Probe Info  		N.A.  LDD0007  [10]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [13]
1c-yne
 Probe Info  		N.A.  LDD0228  [11]
Acrolein
 Probe Info  		C227(0.00); C275(0.00); C433(0.00); C288(0.00)  LDD0217  [14]
Crotonaldehyde
 Probe Info  		C275(0.00); C227(0.00); C288(0.00)  LDD0219  [14]
Methacrolein
 Probe Info  		C227(0.00); C275(0.00); C350(0.00); C288(0.00)  LDD0218  [14]
AOyne
 Probe Info  		13.50  LDD0443  [15]
NAIA_5
 Probe Info  		C350(0.00); C433(0.00)  LDD2223  [16]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C266
 Probe Info  		10.48  LDD1937  [17]
FFF probe13
 Probe Info  		20.00  LDD0475  [18]
FFF probe3
 Probe Info  		20.00  LDD0464  [18]
FFF probe6
 Probe Info  		12.46  LDD0467  [18]
STS-1
 Probe Info  		N.A.  LDD0137  [19]
STS-2
 Probe Info  		N.A.  LDD0139  [19]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C275(2.86); C150(11.15)  LDD0168  [5]
 LDCM0026  4SU-RNA+native RNA HEK-293T C275(2.59); C150(12.67)  LDD0169  [5]
 LDCM0214  AC1 HCT 116 C275(0.93)  LDD0531  [6]
 LDCM0215  AC10 HCT 116 C275(1.68)  LDD0532  [6]
 LDCM0216  AC100 HEK-293T C275(1.20)  LDD0814  [6]
 LDCM0217  AC101 HEK-293T C275(1.11)  LDD0815  [6]
 LDCM0218  AC102 HEK-293T C275(1.15)  LDD0816  [6]
 LDCM0219  AC103 HEK-293T C275(1.15)  LDD0817  [6]
 LDCM0220  AC104 HEK-293T C275(1.41)  LDD0818  [6]
 LDCM0221  AC105 HEK-293T C275(1.75)  LDD0819  [6]
 LDCM0222  AC106 HEK-293T C275(0.88)  LDD0820  [6]
 LDCM0223  AC107 HEK-293T C275(1.23)  LDD0821  [6]
 LDCM0224  AC108 HEK-293T C275(1.29)  LDD0822  [6]
 LDCM0225  AC109 HEK-293T C275(1.29)  LDD0823  [6]
 LDCM0226  AC11 HCT 116 C275(1.55)  LDD0543  [6]
 LDCM0227  AC110 HEK-293T C275(1.49)  LDD0825  [6]
 LDCM0228  AC111 HEK-293T C275(1.46)  LDD0826  [6]
 LDCM0229  AC112 HEK-293T C275(1.47)  LDD0827  [6]
 LDCM0230  AC113 HEK-293T C275(0.83)  LDD0828  [6]
 LDCM0231  AC114 HEK-293T C275(1.18)  LDD0829  [6]
 LDCM0232  AC115 HEK-293T C275(0.98)  LDD0830  [6]
 LDCM0233  AC116 HEK-293T C275(1.04)  LDD0831  [6]
 LDCM0234  AC117 HEK-293T C275(1.68)  LDD0832  [6]
 LDCM0235  AC118 HEK-293T C275(1.21)  LDD0833  [6]
 LDCM0236  AC119 HEK-293T C275(1.60)  LDD0834  [6]
 LDCM0237  AC12 HCT 116 C275(1.25)  LDD0554  [6]
 LDCM0238  AC120 HEK-293T C275(1.08)  LDD0836  [6]
 LDCM0239  AC121 HEK-293T C275(1.00)  LDD0837  [6]
 LDCM0240  AC122 HEK-293T C275(1.45)  LDD0838  [6]
 LDCM0241  AC123 HEK-293T C275(1.05)  LDD0839  [6]
 LDCM0242  AC124 HEK-293T C275(1.45)  LDD0840  [6]
 LDCM0243  AC125 HEK-293T C275(1.69)  LDD0841  [6]
 LDCM0244  AC126 HEK-293T C275(1.43)  LDD0842  [6]
 LDCM0245  AC127 HEK-293T C275(1.43)  LDD0843  [6]
 LDCM0246  AC128 HEK-293T C275(1.16)  LDD0844  [6]
 LDCM0247  AC129 HEK-293T C275(1.34)  LDD0845  [6]
 LDCM0249  AC130 HEK-293T C275(1.20)  LDD0847  [6]
 LDCM0250  AC131 HEK-293T C275(1.29)  LDD0848  [6]
 LDCM0251  AC132 HEK-293T C275(1.43)  LDD0849  [6]
 LDCM0252  AC133 HEK-293T C275(1.29)  LDD0850  [6]
 LDCM0253  AC134 HEK-293T C275(1.02)  LDD0851  [6]
 LDCM0254  AC135 HEK-293T C275(1.22)  LDD0852  [6]
 LDCM0255  AC136 HEK-293T C275(1.05)  LDD0853  [6]
 LDCM0256  AC137 HEK-293T C275(1.08)  LDD0854  [6]
 LDCM0257  AC138 HEK-293T C275(1.02)  LDD0855  [6]
 LDCM0258  AC139 HEK-293T C275(1.17)  LDD0856  [6]
 LDCM0259  AC14 HCT 116 C275(1.46)  LDD0576  [6]
 LDCM0260  AC140 HEK-293T C275(1.13)  LDD0858  [6]
 LDCM0261  AC141 HEK-293T C275(1.08)  LDD0859  [6]
 LDCM0262  AC142 HEK-293T C275(1.16)  LDD0860  [6]
 LDCM0263  AC143 HEK-293T C275(0.95)  LDD0861  [6]
 LDCM0264  AC144 HEK-293T C275(1.35)  LDD0862  [6]
 LDCM0265  AC145 HEK-293T C275(1.16)  LDD0863  [6]
 LDCM0266  AC146 HEK-293T C275(1.08)  LDD0864  [6]
 LDCM0267  AC147 HEK-293T C275(0.83)  LDD0865  [6]
 LDCM0268  AC148 HEK-293T C275(0.69)  LDD0866  [6]
 LDCM0269  AC149 HEK-293T C275(1.52)  LDD0867  [6]
 LDCM0270  AC15 HCT 116 C275(1.74)  LDD0587  [6]
 LDCM0271  AC150 HEK-293T C275(0.97)  LDD0869  [6]
 LDCM0272  AC151 HEK-293T C275(0.89)  LDD0870  [6]
 LDCM0273  AC152 HEK-293T C275(1.12)  LDD0871  [6]
 LDCM0274  AC153 HEK-293T C275(1.04)  LDD0872  [6]
 LDCM0621  AC154 HEK-293T C275(1.11)  LDD2162  [6]
 LDCM0622  AC155 HEK-293T C275(0.85)  LDD2163  [6]
 LDCM0623  AC156 HEK-293T C275(0.97)  LDD2164  [6]
 LDCM0624  AC157 HEK-293T C275(1.19)  LDD2165  [6]
 LDCM0276  AC17 HCT 116 C275(0.97)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C275(1.23)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C275(1.11)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C275(0.96)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C275(1.22)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C275(1.15)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C275(0.98)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C275(1.10)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C275(1.13)  LDD0601  [6]
 LDCM0285  AC25 HEK-293T C275(1.55)  LDD0883  [6]
 LDCM0286  AC26 HEK-293T C275(1.58)  LDD0884  [6]
 LDCM0287  AC27 HEK-293T C275(1.49)  LDD0885  [6]
 LDCM0288  AC28 HEK-293T C275(1.64)  LDD0886  [6]
 LDCM0289  AC29 HEK-293T C275(1.67)  LDD0887  [6]
 LDCM0290  AC3 HCT 116 C275(0.90)  LDD0607  [6]
 LDCM0291  AC30 HEK-293T C275(1.78)  LDD0889  [6]
 LDCM0292  AC31 HEK-293T C275(1.94)  LDD0890  [6]
 LDCM0293  AC32 HEK-293T C275(1.58)  LDD0891  [6]
 LDCM0294  AC33 HEK-293T C275(1.72)  LDD0892  [6]
 LDCM0295  AC34 HEK-293T C275(2.02)  LDD0893  [6]
 LDCM0296  AC35 HCT 116 C275(0.96)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C275(1.06)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C275(1.03)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C275(1.19)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C275(1.05)  LDD0617  [6]
 LDCM0301  AC4 HCT 116 C275(1.04)  LDD0618  [6]
 LDCM0302  AC40 HCT 116 C275(1.25)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C275(1.11)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C275(1.28)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C275(1.32)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C275(1.45)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C275(1.29)  LDD0624  [6]
 LDCM0308  AC46 PaTu 8988t C275(1.21)  LDD1187  [6]
 LDCM0309  AC47 PaTu 8988t C275(1.21)  LDD1188  [6]
 LDCM0310  AC48 PaTu 8988t C275(1.46)  LDD1189  [6]
 LDCM0311  AC49 PaTu 8988t C275(1.84)  LDD1190  [6]
 LDCM0312  AC5 HCT 116 C275(0.96)  LDD0629  [6]
 LDCM0313  AC50 PaTu 8988t C275(1.89)  LDD1192  [6]
 LDCM0314  AC51 PaTu 8988t C275(0.90)  LDD1193  [6]
 LDCM0315  AC52 PaTu 8988t C275(1.54)  LDD1194  [6]
 LDCM0316  AC53 PaTu 8988t C275(2.02)  LDD1195  [6]
 LDCM0317  AC54 PaTu 8988t C275(2.20)  LDD1196  [6]
 LDCM0318  AC55 PaTu 8988t C275(1.27)  LDD1197  [6]
 LDCM0319  AC56 PaTu 8988t C275(1.63)  LDD1198  [6]
 LDCM0320  AC57 HEK-293T C275(1.49)  LDD0918  [6]
 LDCM0321  AC58 HEK-293T C275(0.92)  LDD0919  [6]
 LDCM0322  AC59 HEK-293T C275(0.93)  LDD0920  [6]
 LDCM0323  AC6 HCT 116 C275(1.47)  LDD0640  [6]
 LDCM0324  AC60 HEK-293T C275(0.88)  LDD0922  [6]
 LDCM0325  AC61 HEK-293T C275(0.75)  LDD0923  [6]
 LDCM0326  AC62 HEK-293T C275(0.59)  LDD0924  [6]
 LDCM0327  AC63 HEK-293T C275(0.69)  LDD0925  [6]
 LDCM0328  AC64 HEK-293T C275(0.61)  LDD0926  [6]
 LDCM0329  AC65 HEK-293T C275(0.69)  LDD0927  [6]
 LDCM0330  AC66 HEK-293T C275(0.82)  LDD0928  [6]
 LDCM0331  AC67 HEK-293T C275(0.81)  LDD0929  [6]
 LDCM0332  AC68 HEK-293T C275(0.97)  LDD0930  [6]
 LDCM0333  AC69 HEK-293T C275(1.00)  LDD0931  [6]
 LDCM0334  AC7 HCT 116 C275(1.29)  LDD0651  [6]
 LDCM0335  AC70 HEK-293T C275(1.03)  LDD0933  [6]
 LDCM0336  AC71 HEK-293T C275(1.26)  LDD0934  [6]
 LDCM0337  AC72 HEK-293T C275(0.96)  LDD0935  [6]
 LDCM0338  AC73 HEK-293T C275(0.84)  LDD0936  [6]
 LDCM0339  AC74 HEK-293T C275(1.25)  LDD0937  [6]
 LDCM0340  AC75 HEK-293T C275(1.13)  LDD0938  [6]
 LDCM0341  AC76 HEK-293T C275(1.10)  LDD0939  [6]
 LDCM0342  AC77 HEK-293T C275(1.03)  LDD0940  [6]
 LDCM0343  AC78 HEK-293T C275(1.06)  LDD0941  [6]
 LDCM0344  AC79 HEK-293T C275(1.06)  LDD0942  [6]
 LDCM0345  AC8 HCT 116 C275(1.60)  LDD0662  [6]
 LDCM0346  AC80 HEK-293T C275(1.22)  LDD0944  [6]
 LDCM0347  AC81 HEK-293T C275(1.33)  LDD0945  [6]
 LDCM0348  AC82 HEK-293T C275(1.58)  LDD0946  [6]
 LDCM0349  AC83 HCT 116 C275(0.93)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C275(0.90)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C275(1.03)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C275(1.05)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C275(0.80)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C275(0.91)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C275(0.86)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C275(0.87)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C275(0.85)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C275(1.07)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C275(0.95)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C275(1.20)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C275(0.84)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C275(0.97)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C275(0.98)  LDD0681  [6]
 LDCM0365  AC98 HEK-293T C275(1.02)  LDD0963  [6]
 LDCM0366  AC99 HEK-293T C275(1.57)  LDD0964  [6]
 LDCM0248  AKOS034007472 HCT 116 C275(1.25)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C275(1.59)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C275(2.46)  LDD0592  [6]
 LDCM0156  Aniline NCI-H1299 14.24  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C288(0.85)  LDD0078  [6]
 LDCM0108  Chloroacetamide HeLa C227(0.00); C275(0.00); C433(0.00); C350(0.00)  LDD0222  [14]
 LDCM0632  CL-Sc Hep-G2 C227(20.00)  LDD2227  [16]
 LDCM0367  CL1 HCT 116 C275(0.95)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C275(1.12)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C275(0.92)  LDD0686  [6]
 LDCM0370  CL101 HCT 116 C275(1.51)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C275(0.94)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C275(0.93)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C275(1.14)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C275(1.12)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C275(1.32)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C275(1.21)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C275(1.54)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C275(1.01)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C275(0.81)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C275(1.13)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C275(1.05)  LDD0698  [6]
 LDCM0382  CL112 HEK-293T C275(1.76)  LDD0980  [6]
 LDCM0383  CL113 HEK-293T C275(1.93)  LDD0981  [6]
 LDCM0384  CL114 HEK-293T C275(1.87)  LDD0982  [6]
 LDCM0385  CL115 HEK-293T C275(1.65)  LDD0983  [6]
 LDCM0386  CL116 HEK-293T C275(1.54)  LDD0984  [6]
 LDCM0387  CL117 HCT 116 C275(1.26)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C275(0.97)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C275(1.17)  LDD0706  [6]
 LDCM0390  CL12 HCT 116 C275(1.07)  LDD0707  [6]
 LDCM0391  CL120 HCT 116 C275(1.13)  LDD0708  [6]
 LDCM0392  CL121 PaTu 8988t C275(1.24)  LDD1271  [6]
 LDCM0393  CL122 PaTu 8988t C275(1.38)  LDD1272  [6]
 LDCM0394  CL123 PaTu 8988t C275(1.64)  LDD1273  [6]
 LDCM0395  CL124 PaTu 8988t C275(1.61)  LDD1274  [6]
 LDCM0396  CL125 HEK-293T C275(1.10)  LDD0994  [6]
 LDCM0397  CL126 HEK-293T C275(0.64)  LDD0995  [6]
 LDCM0398  CL127 HEK-293T C275(1.04)  LDD0996  [6]
 LDCM0399  CL128 HEK-293T C275(1.23)  LDD0997  [6]
 LDCM0400  CL13 HCT 116 C275(0.82)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C275(0.94)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C275(0.74)  LDD0719  [6]
 LDCM0403  CL16 PaTu 8988t C275(1.50)  LDD1282  [6]
 LDCM0404  CL17 PaTu 8988t C275(1.46)  LDD1283  [6]
 LDCM0405  CL18 PaTu 8988t C275(1.67)  LDD1284  [6]
 LDCM0406  CL19 PaTu 8988t C275(1.53)  LDD1285  [6]
 LDCM0407  CL2 HCT 116 C275(0.94)  LDD0724  [6]
 LDCM0408  CL20 PaTu 8988t C275(1.80)  LDD1287  [6]
 LDCM0409  CL21 PaTu 8988t C275(1.92)  LDD1288  [6]
 LDCM0410  CL22 PaTu 8988t C275(1.72)  LDD1289  [6]
 LDCM0411  CL23 PaTu 8988t C275(1.88)  LDD1290  [6]
 LDCM0412  CL24 PaTu 8988t C275(1.59)  LDD1291  [6]
 LDCM0413  CL25 PaTu 8988t C275(1.53)  LDD1292  [6]
 LDCM0414  CL26 PaTu 8988t C275(1.85)  LDD1293  [6]
 LDCM0415  CL27 PaTu 8988t C275(1.80)  LDD1294  [6]
 LDCM0416  CL28 PaTu 8988t C275(1.98)  LDD1295  [6]
 LDCM0417  CL29 PaTu 8988t C275(1.87)  LDD1296  [6]
 LDCM0418  CL3 HCT 116 C275(0.65)  LDD0735  [6]
 LDCM0419  CL30 PaTu 8988t C275(1.70)  LDD1298  [6]
 LDCM0420  CL31 HEK-293T C275(1.25)  LDD1018  [6]
 LDCM0421  CL32 HEK-293T C275(1.24)  LDD1019  [6]
 LDCM0422  CL33 HEK-293T C275(1.14)  LDD1020  [6]
 LDCM0423  CL34 HEK-293T C275(1.00)  LDD1021  [6]
 LDCM0424  CL35 HEK-293T C275(1.25)  LDD1022  [6]
 LDCM0425  CL36 HEK-293T C275(1.01)  LDD1023  [6]
 LDCM0426  CL37 HEK-293T C275(1.03)  LDD1024  [6]
 LDCM0428  CL39 HEK-293T C275(1.30)  LDD1026  [6]
 LDCM0429  CL4 HCT 116 C275(0.72)  LDD0746  [6]
 LDCM0430  CL40 HEK-293T C275(1.09)  LDD1028  [6]
 LDCM0431  CL41 HEK-293T C275(1.22)  LDD1029  [6]
 LDCM0432  CL42 HEK-293T C275(1.20)  LDD1030  [6]
 LDCM0433  CL43 HEK-293T C275(1.02)  LDD1031  [6]
 LDCM0434  CL44 HEK-293T C275(1.29)  LDD1032  [6]
 LDCM0435  CL45 HEK-293T C275(1.20)  LDD1033  [6]
 LDCM0436  CL46 HEK-293T C275(1.30)  LDD1034  [6]
 LDCM0437  CL47 HEK-293T C275(1.12)  LDD1035  [6]
 LDCM0438  CL48 HEK-293T C275(1.31)  LDD1036  [6]
 LDCM0439  CL49 HEK-293T C275(1.29)  LDD1037  [6]
 LDCM0440  CL5 HCT 116 C275(0.88)  LDD0757  [6]
 LDCM0441  CL50 HEK-293T C275(1.15)  LDD1039  [6]
 LDCM0442  CL51 HEK-293T C275(0.98)  LDD1040  [6]
 LDCM0443  CL52 HEK-293T C275(0.98)  LDD1041  [6]
 LDCM0444  CL53 HEK-293T C275(0.89)  LDD1042  [6]
 LDCM0445  CL54 HEK-293T C275(0.96)  LDD1043  [6]
 LDCM0446  CL55 HEK-293T C275(1.03)  LDD1044  [6]
 LDCM0447  CL56 HEK-293T C275(0.93)  LDD1045  [6]
 LDCM0448  CL57 HEK-293T C275(0.99)  LDD1046  [6]
 LDCM0449  CL58 HEK-293T C275(0.90)  LDD1047  [6]
 LDCM0450  CL59 HEK-293T C275(1.27)  LDD1048  [6]
 LDCM0451  CL6 HCT 116 C275(0.74)  LDD0768  [6]
 LDCM0452  CL60 HEK-293T C275(1.17)  LDD1050  [6]
 LDCM0453  CL61 HCT 116 C275(0.93)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C275(0.96)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C275(1.07)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C275(1.19)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C275(1.11)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C275(1.42)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C275(1.20)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C275(1.33)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C275(0.82)  LDD0778  [6]
 LDCM0462  CL7 HCT 116 C275(0.87)  LDD0779  [6]
 LDCM0463  CL70 HCT 116 C275(0.96)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C275(1.19)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C275(1.28)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C275(1.24)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C275(1.43)  LDD0784  [6]
 LDCM0469  CL76 PaTu 8988t C275(1.23); C288(1.37)  LDD1348  [6]
 LDCM0470  CL77 PaTu 8988t C275(1.66); C288(1.80)  LDD1349  [6]
 LDCM0471  CL78 PaTu 8988t C275(1.74); C288(1.68)  LDD1350  [6]
 LDCM0472  CL79 PaTu 8988t C275(1.17); C288(0.59)  LDD1351  [6]
 LDCM0473  CL8 HCT 116 C275(0.76)  LDD0790  [6]
 LDCM0474  CL80 PaTu 8988t C275(1.87); C288(2.06)  LDD1353  [6]
 LDCM0475  CL81 PaTu 8988t C275(1.85); C288(1.78)  LDD1354  [6]
 LDCM0476  CL82 PaTu 8988t C275(1.50); C288(1.21)  LDD1355  [6]
 LDCM0477  CL83 PaTu 8988t C275(2.03); C288(2.28)  LDD1356  [6]
 LDCM0478  CL84 PaTu 8988t C275(2.20); C288(3.20)  LDD1357  [6]
 LDCM0479  CL85 PaTu 8988t C275(1.39); C288(1.49)  LDD1358  [6]
 LDCM0480  CL86 PaTu 8988t C275(1.97); C288(2.22)  LDD1359  [6]
 LDCM0481  CL87 PaTu 8988t C275(2.11); C288(2.46)  LDD1360  [6]
 LDCM0482  CL88 PaTu 8988t C275(1.73); C288(1.46)  LDD1361  [6]
 LDCM0483  CL89 PaTu 8988t C275(2.02); C288(2.95)  LDD1362  [6]
 LDCM0484  CL9 HCT 116 C275(0.83)  LDD0801  [6]
 LDCM0485  CL90 PaTu 8988t C275(2.15); C288(2.31)  LDD1364  [6]
 LDCM0486  CL91 HCT 116 C275(1.02)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C275(0.73)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C275(0.79)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C275(1.15)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C275(1.12)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C275(0.93)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C275(0.83)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C275(0.90)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C275(0.91)  LDD0811  [6]
 LDCM0634  CY-0357 Hep-G2 C288(1.49)  LDD2228  [16]
 LDCM0495  E2913 HEK-293T C350(1.04); C275(0.97); C433(1.13); C150(1.04)  LDD1698  [20]
 LDCM0625  F8 Ramos C275(1.01); C288(1.39); C227(0.42); 0.72  LDD2187  [21]
 LDCM0572  Fragment10 Ramos C275(1.13); C288(0.69); C227(0.49)  LDD2189  [21]
 LDCM0573  Fragment11 Ramos C275(2.69); C227(0.25); 0.16  LDD2190  [21]
 LDCM0574  Fragment12 Ramos C275(1.09); C288(1.03); C227(0.49); 1.36  LDD2191  [21]
 LDCM0575  Fragment13 Ramos C275(1.16); C288(1.02); C227(1.62); 1.08  LDD2192  [21]
 LDCM0576  Fragment14 Ramos C275(0.74); C288(0.83); C227(0.68); 0.73  LDD2193  [21]
 LDCM0579  Fragment20 Ramos C275(1.15); C288(0.66); C227(0.54); 0.69  LDD2194  [21]
 LDCM0580  Fragment21 Ramos C275(1.21); C288(0.86); C227(0.69); 1.16  LDD2195  [21]
 LDCM0582  Fragment23 Ramos C275(1.57); C288(0.86); C227(1.02); 2.29  LDD2196  [21]
 LDCM0578  Fragment27 Ramos C275(1.11); C288(0.89); C227(0.80); 2.27  LDD2197  [21]
 LDCM0586  Fragment28 Ramos C275(1.30); C288(0.23); C227(0.87); 0.83  LDD2198  [21]
 LDCM0588  Fragment30 Ramos C275(1.05); C288(1.01); C227(0.65); 0.77  LDD2199  [21]
 LDCM0589  Fragment31 Ramos C275(1.01); C288(0.84); C227(0.92); 1.20  LDD2200  [21]
 LDCM0590  Fragment32 Ramos C275(1.04); C288(1.56); C227(0.36)  LDD2201  [21]
 LDCM0468  Fragment33 HCT 116 C275(1.07)  LDD0785  [6]
 LDCM0596  Fragment38 Ramos C275(0.89); C288(0.76); C227(0.65); 0.47  LDD2203  [21]
 LDCM0566  Fragment4 Ramos C275(1.02); C288(0.90); C227(0.45); 0.64  LDD2184  [21]
 LDCM0427  Fragment51 HEK-293T C275(1.00)  LDD1025  [6]
 LDCM0610  Fragment52 Ramos C275(1.00); C288(1.21); C227(0.57); 0.94  LDD2204  [21]
 LDCM0614  Fragment56 Ramos C275(1.03); C288(1.26); C227(0.66); 1.54  LDD2205  [21]
 LDCM0569  Fragment7 Ramos C275(1.01); C288(0.81); C227(0.41); 0.58  LDD2186  [21]
 LDCM0571  Fragment9 Ramos C275(1.43); C288(1.23); C227(0.34)  LDD2188  [21]
 LDCM0107  IAA HeLa C227(0.00); C275(0.00); H349(0.00); H178(0.00)  LDD0221  [14]
 LDCM0022  KB02 HCT 116 C288(1.27); C275(1.45)  LDD0080  [6]
 LDCM0023  KB03 HCT 116 C288(1.38); C275(1.18)  LDD0081  [6]
 LDCM0024  KB05 HCT 116 C288(1.30); C275(1.24)  LDD0082  [6]
 LDCM0109  NEM HeLa H178(0.00); H326(0.00); C275(0.00); C288(0.00)  LDD0223  [14]
 LDCM0628  OTUB2-COV-1 HEK-293T C275(1.03)  LDD2207  [22]
 LDCM0131  RA190 MM1.R C288(1.37)  LDD0304  [23]
 LDCM0112  W16 Hep-G2 C275(0.55)  LDD0239  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Eukaryotic initiation factor 4A-I (EIF4A1) DEAD box helicase family P60842
Eukaryotic initiation factor 4A-II (EIF4A2) DEAD box helicase family Q14240
Eukaryotic initiation factor 4A-III (EIF4A3) DEAD box helicase family P38919
Presenilin-2 (PSEN2) Peptidase A22A family P49810
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Apolipoprotein E (APOE) Apolipoprotein A1/A4/E family P02649
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transcription factor p65 (RELA) . Q04206
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Small ribosomal subunit protein uS15 (RPS13) Universal ribosomal protein uS15 family P62277

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
12 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
13 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
14 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
15 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
16 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
17 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
18 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
19 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
20 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
21 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
22 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
23 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.