Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C266  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 43 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP04581  Holocytochrome c-type synthase (HCCS) 20.4
 LDTP04163  Prolyl endopeptidase (PREP) 20.4
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 18.1
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 17.1
 LDTP06617  Ceramide glucosyltransferase (UGCG) 14.3
 LDTP02748  Cytochrome c oxidase subunit 6B1 (COX6B1) 12.7
 LDTP03540  Heme oxygenase 2 (HMOX2) 11.6
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 11.6
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 11.4
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 10.9
 LDTP05632  Mitochondrial-processing peptidase subunit alpha (PMPCA) 10.6
 LDTP01803  Adenosine deaminase (ADA) 10.6
 LDTP12040  Prostaglandin E synthase 2 (PTGES2) 10.6
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 10.5
 LDTP02264  Asparagine synthetase [glutamine-hydrolyzing] (ASNS) 10.3
 LDTP04689  Adenosine kinase (ADK) 10.2
 LDTP07525  Protein arginine N-methyltransferase 9 (PRMT9) 10.1
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 10.0
 LDTP11319  Threonine--tRNA ligase, mitochondrial (TARS2) 9.9
 LDTP03769  Sterol O-acyltransferase 1 (SOAT1) 9.8
 LDTP02359  Heme oxygenase 1 (HMOX1) 9.6
 LDTP09044  ATPase family gene 2 protein homolog A (AFG2A) 9.1
 LDTP17022  Secernin-3 (SCRN3) 9.0
 LDTP00697  Cytochrome b5 type B (CYB5B) 8.8
 LDTP06307  Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1) 8.8
 LDTP10188  FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1) 8.6
 LDTP07577  Serine/threonine-protein kinase ULK3 (ULK3) 8.6
 LDTP06849  Prolyl endopeptidase-like (PREPL) 8.6
 LDTP05917  Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) 8.6
 LDTP14904  DNA-directed RNA polymerase I subunit RPA43 (POLR1F) 8.5
 LDTP12868  Endoplasmic reticulum aminopeptidase 1 (ERAP1) 8.5
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 8.2
 LDTP09396  Minor histocompatibility antigen H13 (HM13) 8.1
 LDTP11268  Acireductone dioxygenase (ADI1) 8.1
 LDTP04569  Geranylgeranyl transferase type-2 subunit beta (RABGGTB) 7.9
 LDTP09088  Phospholipase A2 group XV (PLA2G15) 7.9
 LDTP00089  Glycerol-3-phosphate phosphatase (PGP) 7.8
 LDTP16070  Epimerase family protein SDR39U1 (SDR39U1) 7.7
 LDTP13056  Leucine--tRNA ligase, cytoplasmic (LARS1) 7.7
 LDTP02254  ATP-dependent translocase ABCB1 (ABCB1) 7.7
 LDTP10981  Mitochondrial intermediate peptidase (MIPEP) 7.7
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 7.6
 LDTP05066  Signal peptidase complex catalytic subunit SEC11A (SEC11A) 7.6
Transporter and channel
Click to Show/Hide to Show 31 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 23.1
 LDTP08881  Transmembrane protein 199 (TMEM199) 21.6
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 19.8
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 17.8
 LDTP15948  Transmembrane protein 126A (TMEM126A) 17.3
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 15.8
 LDTP20002  Transmembrane protein 160 (TMEM160) 15.8
 LDTP11136  Sugar transporter SWEET1 (SLC50A1) 14.5
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 12.6
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 11.2
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 10.9
 LDTP11162  Solute carrier family 25 member 33 (SLC25A33) 10.8
 LDTP01217  Metaxin-2 (MTX2) 10.6
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 10.6
 LDTP04956  Mitochondrial import inner membrane translocase subunit Tim10 (TIMM10) 10.5
 LDTP14099  Mitochondrial import inner membrane translocase subunit Tim22 (TIMM22) 9.3
 LDTP08981  Cytochrome c oxidase assembly protein COX18, mitochondrial (COX18) 9.3
 LDTP00970  Gasdermin-E (GSDME) 9.1
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 9.0
 LDTP16069  Peroxisomal membrane protein 2 (PXMP2) 8.8
 LDTP03546  Translocator protein (TSPO) 8.8
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 8.4
 LDTP00235  Membrane-associated progesterone receptor component 1 (PGRMC1) 8.3
 LDTP14200  Mitochondrial ornithine transporter 1 (SLC25A15) 8.3
 LDTP09788  Sorting nexin-19 (SNX19) 8.3
 LDTP07058  Transmembrane protein 201 (TMEM201) 8.2
 LDTP07236  Protein GPR107 (GPR107) 8.1
 LDTP06633  Reticulon-1 (RTN1) 7.8
 LDTP05625  AP-1 complex subunit beta-1 (AP1B1) 7.7
 LDTP05900  Metaxin-1 (MTX1) 7.6
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) 7.6
Transcription factor
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP00791  Forkhead box protein O3 (FOXO3) 8.5
Other
Click to Show/Hide to Show 30 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP11076  Apolipoprotein L2 (APOL2) 23.9
 LDTP19372  Tetratricopeptide repeat protein 38 (TTC38) 22.5
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 15.9
 LDTP15623  Neuferricin (CYB5D2) 14.4
 LDTP01608  Proteasome assembly chaperone 1 (PSMG1) 14.4
 LDTP07333  Integrator complex subunit 3 (INTS3) 13.4
 LDTP13622  NFU1 iron-sulfur cluster scaffold homolog, mitochondrial (NFU1) 13.1
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 12.9
 LDTP19860  Coiled-coil domain-containing protein 97 (CCDC97) 12.5
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 12.3
 LDTP00105  Protein unc-119 homolog B (UNC119B) 12.0
 LDTP11978  HAUS augmin-like complex subunit 4 (HAUS4) 11.5
 LDTP07042  Protein Smaug homolog 2 (SAMD4B) 11.5
 LDTP16192  Mitochondrial fission process protein 1 (MTFP1) 10.8
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 10.7
 LDTP06881  Programmed cell death protein 4 (PDCD4) 10.5
 LDTP12369  Bromodomain-containing protein 7 (BRD7) 9.9
 LDTP04092  Crk-like protein (CRKL) 9.6
 LDTP14939  Membralin (TMEM259) 9.3
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 9.2
 LDTP14217  Lipid droplet-regulating VLDL assembly factor AUP1 (AUP1) 8.9
 LDTP17481  Uncharacterized protein C15orf39 (C15orf39) 8.8
 LDTP11115  Leucine zipper putative tumor suppressor 2 (LZTS2) 8.6
 LDTP06868  Angiomotin (AMOT) 8.2
 LDTP10214  Splicing factor ESS-2 homolog (ESS2) 8.1
 LDTP16078  Heme-binding protein 1 (HEBP1) 7.9
 LDTP13525  Muskelin (MKLN1) 7.9
 LDTP13902  Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) 7.9
 LDTP19568  Uncharacterized protein C1orf122 (C1orf122) 7.8
 LDTP04369  Peroxisomal targeting signal 1 receptor (PEX5) 7.6

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587