Details of the Target

General Information of Target

Target ID LDTP06648
Target Name Lanosterol 14-alpha demethylase (CYP51A1)
Gene Name CYP51A1
Gene ID 1595
Synonyms
CYP51; Lanosterol 14-alpha demethylase; LDM; EC 1.14.14.154; CYPLI; Cytochrome P450 51A1; CYP51A1; Cytochrome P450-14DM; Cytochrome P45014DM; Cytochrome P450LI; Sterol 14-alpha demethylase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAAAGMLLLGLLQAGGSVLGQAMEKVTGGNLLSMLLIACAFTLSLVYLIRLAAGHLVQL
PAGVKSPPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAA
ALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSI
IEKETKEYFESWGESGEKNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGF
SHAAWLLPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQSQEKIDDILQTLLDATYKDGR
PLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTY
DQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDS
WVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDL
IDGYFPTVNYTTMIHTPENPVIRYKRRSK
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
Cytochrome P450 family
Subcellular location
Endoplasmic reticulum membrane
Function
Sterol 14alpha-demethylase that plays a critical role in the cholesterol biosynthesis pathway, being cholesterol the major sterol component in mammalian membranes as well as a precursor for bile acid and steroid hormone synthesis. Cytochrome P450 monooxygenase that catalyzes the three-step oxidative removal of the 14alpha-methyl group (C-32) of sterols such as lanosterol (lanosta-8,24-dien-3beta-ol) and 24,25-dihydrolanosterol (DHL) in the form of formate, and converts the sterols to 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol and 4,4-dimethyl-8,14-cholestadien-3beta-ol, respectively, which are intermediates of cholesterol biosynthesis. Can also demethylate substrates not intrinsic to mammals, such as eburicol (24-methylene-24,25-dihydrolanosterol), but at a lower rate than DHL.
TTD ID
T32972
Uniprot ID
Q16850
DrugMap ID
TT67TDP
Ensemble ID
ENST00000003100.13
HGNC ID
HGNC:2649
ChEMBL ID
CHEMBL3849

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL51 SNV: p.L32V .
HDMYZ SNV: p.S18A DBIA    Probe Info 
HT115 SNV: p.K342Q .
Ishikawa (Heraklio) 02 ER SNV: p.L377S DBIA    Probe Info 
KASUMI2 SNV: p.V64L DBIA    Probe Info 
LS180 SNV: p.W245S DBIA    Probe Info 
MFE296 Deletion: p.K342NfsTer4 DBIA    Probe Info 
SW1271 SNV: p.E96Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Alkylaryl probe 2
 Probe Info  		14.00  LDD0389  [1]
C-Sul
 Probe Info  		3.21  LDD0066  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
YN-4
 Probe Info  		100.00  LDD0445  [3]
STPyne
 Probe Info  		K156(10.00); K160(6.15); K261(2.17); K436(5.26)  LDD0277  [4]
ONAyne
 Probe Info  		N.A.  LDD0273  [4]
BTD
 Probe Info  		C337(1.56)  LDD1700  [5]
AHL-Pu-1
 Probe Info  		C449(2.29)  LDD0169  [6]
HPAP
 Probe Info  		3.16  LDD0062  [7]
DBIA
 Probe Info  		C345(1.22); C449(0.64)  LDD0531  [8]
ATP probe
 Probe Info  		K442(0.00); K166(0.00)  LDD0199  [9]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [10]
ATP probe
 Probe Info  		N.A.  LDD0035  [11]
IPM
 Probe Info  		N.A.  LDD0025  [12]
NAIA_4
 Probe Info  		N.A.  LDD2226  [13]
TFBX
 Probe Info  		N.A.  LDD0027  [12]
WYneN
 Probe Info  		N.A.  LDD0021  [14]
1c-yne
 Probe Info  		K141(0.00); K436(0.00)  LDD0228  [15]
Acrolein
 Probe Info  		H171(0.00); C345(0.00)  LDD0217  [16]
Methacrolein
 Probe Info  		N.A.  LDD0218  [16]
NAIA_5
 Probe Info  		C455(0.00); C372(0.00); C215(0.00); C343(0.00)  LDD2223  [13]
PAL-AfBPP Probe
Click To Hide/Show 163 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		6.36  LDD1714  [17]
C022
 Probe Info  		11.08  LDD1728  [17]
C027
 Probe Info  		7.16  LDD1733  [17]
C040
 Probe Info  		15.56  LDD1740  [17]
C041
 Probe Info  		6.96  LDD1741  [17]
C055
 Probe Info  		12.38  LDD1752  [17]
C056
 Probe Info  		27.28  LDD1753  [17]
C063
 Probe Info  		18.25  LDD1760  [17]
C067
 Probe Info  		5.03  LDD1763  [17]
C070
 Probe Info  		22.63  LDD1766  [17]
C072
 Probe Info  		21.86  LDD1768  [17]
C087
 Probe Info  		11.24  LDD1779  [17]
C091
 Probe Info  		18.51  LDD1782  [17]
C092
 Probe Info  		19.56  LDD1783  [17]
C094
 Probe Info  		28.64  LDD1785  [17]
C100
 Probe Info  		5.17  LDD1789  [17]
C106
 Probe Info  		24.25  LDD1793  [17]
C107
 Probe Info  		8.82  LDD1794  [17]
C108
 Probe Info  		18.77  LDD1795  [17]
C112
 Probe Info  		26.35  LDD1799  [17]
C129
 Probe Info  		14.42  LDD1811  [17]
C130
 Probe Info  		12.38  LDD1812  [17]
C134
 Probe Info  		35.75  LDD1816  [17]
C135
 Probe Info  		10.13  LDD1817  [17]
C138
 Probe Info  		5.24  LDD1820  [17]
C140
 Probe Info  		9.92  LDD1822  [17]
C141
 Probe Info  		9.06  LDD1823  [17]
C143
 Probe Info  		20.53  LDD1825  [17]
C145
 Probe Info  		15.24  LDD1827  [17]
C147
 Probe Info  		6.96  LDD1829  [17]
C153
 Probe Info  		19.03  LDD1834  [17]
C158
 Probe Info  		15.56  LDD1838  [17]
C159
 Probe Info  		15.67  LDD1839  [17]
C160
 Probe Info  		15.78  LDD1840  [17]
C161
 Probe Info  		12.73  LDD1841  [17]
C163
 Probe Info  		6.82  LDD1843  [17]
C164
 Probe Info  		5.10  LDD1844  [17]
C165
 Probe Info  		13.09  LDD1845  [17]
C166
 Probe Info  		28.84  LDD1846  [17]
C169
 Probe Info  		99.73  LDD1849  [17]
C170
 Probe Info  		10.41  LDD1850  [17]
C173
 Probe Info  		7.89  LDD1853  [17]
C174
 Probe Info  		15.03  LDD1854  [17]
C177
 Probe Info  		12.04  LDD1856  [17]
C178
 Probe Info  		26.35  LDD1857  [17]
C186
 Probe Info  		20.25  LDD1864  [17]
C187
 Probe Info  		37.27  LDD1865  [17]
C191
 Probe Info  		11.55  LDD1868  [17]
C193
 Probe Info  		5.82  LDD1869  [17]
C194
 Probe Info  		11.39  LDD1870  [17]
C196
 Probe Info  		9.71  LDD1872  [17]
C197
 Probe Info  		15.89  LDD1873  [17]
C198
 Probe Info  		13.64  LDD1874  [17]
C199
 Probe Info  		10.85  LDD1875  [17]
C201
 Probe Info  		86.82  LDD1877  [17]
C204
 Probe Info  		5.54  LDD1879  [17]
C206
 Probe Info  		23.75  LDD1881  [17]
C207
 Probe Info  		24.42  LDD1882  [17]
C210
 Probe Info  		81.57  LDD1884  [17]
C214
 Probe Info  		11.31  LDD1888  [17]
C215
 Probe Info  		10.56  LDD1889  [17]
C217
 Probe Info  		5.31  LDD1891  [17]
C218
 Probe Info  		20.53  LDD1892  [17]
C219
 Probe Info  		7.62  LDD1893  [17]
C220
 Probe Info  		21.11  LDD1894  [17]
C222
 Probe Info  		6.41  LDD1896  [17]
C225
 Probe Info  		11.47  LDD1898  [17]
C226
 Probe Info  		5.78  LDD1899  [17]
C228
 Probe Info  		22.94  LDD1901  [17]
C231
 Probe Info  		11.31  LDD1904  [17]
C232
 Probe Info  		72.00  LDD1905  [17]
C234
 Probe Info  		8.17  LDD1907  [17]
C235
 Probe Info  		26.54  LDD1908  [17]
C238
 Probe Info  		11.08  LDD1911  [17]
C239
 Probe Info  		9.65  LDD1912  [17]
C246
 Probe Info  		23.92  LDD1919  [17]
C249
 Probe Info  		20.97  LDD1922  [17]
C252
 Probe Info  		8.94  LDD1925  [17]
C258
 Probe Info  		7.11  LDD1931  [17]
C260
 Probe Info  		6.11  LDD1932  [17]
C266
 Probe Info  		11.63  LDD1937  [17]
C270
 Probe Info  		10.41  LDD1940  [17]
C271
 Probe Info  		14.72  LDD1941  [17]
C273
 Probe Info  		9.00  LDD1943  [17]
C275
 Probe Info  		5.66  LDD1945  [17]
C277
 Probe Info  		10.70  LDD1947  [17]
C282
 Probe Info  		14.93  LDD1952  [17]
C285
 Probe Info  		21.56  LDD1955  [17]
C286
 Probe Info  		7.11  LDD1956  [17]
C287
 Probe Info  		20.39  LDD1957  [17]
C288
 Probe Info  		10.48  LDD1958  [17]
C289
 Probe Info  		44.02  LDD1959  [17]
C290
 Probe Info  		5.98  LDD1960  [17]
C293
 Probe Info  		20.39  LDD1963  [17]
C296
 Probe Info  		17.27  LDD1966  [17]
C297
 Probe Info  		10.34  LDD1967  [17]
C299
 Probe Info  		7.36  LDD1968  [17]
C304
 Probe Info  		10.85  LDD1973  [17]
C305
 Probe Info  		9.65  LDD1974  [17]
C307
 Probe Info  		7.01  LDD1975  [17]
C314
 Probe Info  		15.89  LDD1981  [17]
C317
 Probe Info  		10.20  LDD1983  [17]
C320
 Probe Info  		7.01  LDD1986  [17]
C322
 Probe Info  		7.01  LDD1988  [17]
C326
 Probe Info  		7.67  LDD1990  [17]
C327
 Probe Info  		5.86  LDD1991  [17]
C338
 Probe Info  		10.27  LDD2001  [17]
C339
 Probe Info  		11.55  LDD2002  [17]
C346
 Probe Info  		11.88  LDD2007  [17]
C347
 Probe Info  		5.28  LDD2008  [17]
C348
 Probe Info  		66.72  LDD2009  [17]
C349
 Probe Info  		15.03  LDD2010  [17]
C350
 Probe Info  		49.52  LDD2011  [17]
C353
 Probe Info  		12.82  LDD2014  [17]
C354
 Probe Info  		16.56  LDD2015  [17]
C355
 Probe Info  		34.06  LDD2016  [17]
C356
 Probe Info  		10.48  LDD2017  [17]
C362
 Probe Info  		57.68  LDD2023  [17]
C363
 Probe Info  		39.40  LDD2024  [17]
C364
 Probe Info  		37.01  LDD2025  [17]
C366
 Probe Info  		7.62  LDD2027  [17]
C367
 Probe Info  		6.02  LDD2028  [17]
C373
 Probe Info  		9.85  LDD2033  [17]
C376
 Probe Info  		10.41  LDD2036  [17]
C378
 Probe Info  		9.51  LDD2037  [17]
C380
 Probe Info  		8.63  LDD2039  [17]
C382
 Probe Info  		22.16  LDD2041  [17]
C384
 Probe Info  		10.56  LDD2043  [17]
C386
 Probe Info  		13.74  LDD2045  [17]
C388
 Probe Info  		90.51  LDD2047  [17]
C389
 Probe Info  		8.28  LDD2048  [17]
C390
 Probe Info  		51.63  LDD2049  [17]
C391
 Probe Info  		22.78  LDD2050  [17]
C396
 Probe Info  		5.03  LDD2055  [17]
C399
 Probe Info  		8.88  LDD2058  [17]
C403
 Probe Info  		33.36  LDD2061  [17]
C407
 Probe Info  		20.11  LDD2064  [17]
C413
 Probe Info  		41.36  LDD2069  [17]
C416
 Probe Info  		5.06  LDD2071  [17]
C419
 Probe Info  		11.08  LDD2074  [17]
C420
 Probe Info  		20.11  LDD2075  [17]
C424
 Probe Info  		11.63  LDD2079  [17]
C426
 Probe Info  		30.06  LDD2081  [17]
C428
 Probe Info  		5.03  LDD2083  [17]
C429
 Probe Info  		11.79  LDD2084  [17]
C431
 Probe Info  		29.86  LDD2086  [17]
C433
 Probe Info  		14.12  LDD2088  [17]
FFF probe11
 Probe Info  		20.00  LDD0471  [18]
FFF probe12
 Probe Info  		5.77  LDD0473  [18]
FFF probe13
 Probe Info  		17.82  LDD0475  [18]
FFF probe14
 Probe Info  		20.00  LDD0477  [18]
FFF probe15
 Probe Info  		8.95  LDD0478  [18]
FFF probe2
 Probe Info  		20.00  LDD0463  [18]
FFF probe3
 Probe Info  		20.00  LDD0464  [18]
FFF probe6
 Probe Info  		20.00  LDD0467  [18]
FFF probe7
 Probe Info  		20.00  LDD0483  [18]
FFF probe9
 Probe Info  		10.65  LDD0470  [18]
JN0003
 Probe Info  		20.00  LDD0469  [18]
STS-1
 Probe Info  		N.A.  LDD0136  [19]
STS-2
 Probe Info  		N.A.  LDD0138  [19]
A-DA
 Probe Info  		2.01  LDD0145  [20]
BD-F
 Probe Info  		L247(0.00); G238(0.00); G239(0.00)  LDD0024  [21]
OEA-DA
 Probe Info  		11.78  LDD0046  [22]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C366(0.60)  LDD2142  [5]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C366(0.73)  LDD2112  [5]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C366(1.27); C337(1.16)  LDD2117  [5]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C337(1.10)  LDD2152  [5]
 LDCM0025  4SU-RNA HEK-293T C345(2.51)  LDD0172  [6]
 LDCM0026  4SU-RNA+native RNA HEK-293T C449(2.29)  LDD0169  [6]
 LDCM0214  AC1 HCT 116 C345(1.22); C449(0.64)  LDD0531  [8]
 LDCM0215  AC10 HCT 116 C345(0.90); C449(0.77)  LDD0532  [8]
 LDCM0216  AC100 HCT 116 C345(0.72); C449(1.04)  LDD0533  [8]
 LDCM0217  AC101 HCT 116 C345(0.75); C449(1.18)  LDD0534  [8]
 LDCM0218  AC102 HCT 116 C345(0.72); C449(1.15)  LDD0535  [8]
 LDCM0219  AC103 HCT 116 C345(0.62); C449(1.04)  LDD0536  [8]
 LDCM0220  AC104 HCT 116 C345(0.66); C449(1.03)  LDD0537  [8]
 LDCM0221  AC105 HCT 116 C345(0.65); C449(1.04)  LDD0538  [8]
 LDCM0222  AC106 HCT 116 C345(0.64); C449(1.01)  LDD0539  [8]
 LDCM0223  AC107 HCT 116 C345(0.61); C449(1.00)  LDD0540  [8]
 LDCM0224  AC108 HCT 116 C345(0.73); C449(1.06)  LDD0541  [8]
 LDCM0225  AC109 HCT 116 C345(0.84); C449(1.13)  LDD0542  [8]
 LDCM0226  AC11 HCT 116 C345(0.89); C449(0.80)  LDD0543  [8]
 LDCM0227  AC110 HCT 116 C345(0.73); C449(1.04)  LDD0544  [8]
 LDCM0228  AC111 HCT 116 C345(0.71); C449(0.98)  LDD0545  [8]
 LDCM0229  AC112 HCT 116 C345(0.65); C449(1.05)  LDD0546  [8]
 LDCM0230  AC113 HCT 116 C345(1.00); C449(0.97)  LDD0547  [8]
 LDCM0231  AC114 HCT 116 C345(1.07); C449(0.87)  LDD0548  [8]
 LDCM0232  AC115 HCT 116 C345(0.95); C449(0.73)  LDD0549  [8]
 LDCM0233  AC116 HCT 116 C345(0.89); C449(0.76)  LDD0550  [8]
 LDCM0234  AC117 HCT 116 C345(0.95); C449(0.99)  LDD0551  [8]
 LDCM0235  AC118 HCT 116 C345(0.99); C449(1.00)  LDD0552  [8]
 LDCM0236  AC119 HCT 116 C345(1.02); C449(0.96)  LDD0553  [8]
 LDCM0237  AC12 HCT 116 C345(0.96); C449(0.88)  LDD0554  [8]
 LDCM0238  AC120 HCT 116 C345(0.93); C449(0.89)  LDD0555  [8]
 LDCM0239  AC121 HCT 116 C345(1.22); C449(1.14)  LDD0556  [8]
 LDCM0240  AC122 HCT 116 C345(1.18); C449(0.90)  LDD0557  [8]
 LDCM0241  AC123 HCT 116 C345(1.25); C449(1.50)  LDD0558  [8]
 LDCM0242  AC124 HCT 116 C345(1.14); C449(1.05)  LDD0559  [8]
 LDCM0243  AC125 HCT 116 C345(1.14); C449(0.92)  LDD0560  [8]
 LDCM0244  AC126 HCT 116 C345(1.21); C449(0.82)  LDD0561  [8]
 LDCM0245  AC127 HCT 116 C345(1.12); C449(0.87)  LDD0562  [8]
 LDCM0246  AC128 HEK-293T C345(0.61); C449(1.35)  LDD0844  [8]
 LDCM0247  AC129 HEK-293T C345(0.47); C449(0.67)  LDD0845  [8]
 LDCM0249  AC130 HEK-293T C345(0.52); C449(0.95)  LDD0847  [8]
 LDCM0250  AC131 HEK-293T C345(0.77); C449(0.73)  LDD0848  [8]
 LDCM0251  AC132 HEK-293T C345(0.53); C449(0.86)  LDD0849  [8]
 LDCM0252  AC133 HEK-293T C345(0.59); C449(0.94)  LDD0850  [8]
 LDCM0253  AC134 HEK-293T C345(0.69); C449(0.99)  LDD0851  [8]
 LDCM0254  AC135 HEK-293T C345(0.88); C449(0.80)  LDD0852  [8]
 LDCM0255  AC136 HEK-293T C345(0.73); C449(0.86)  LDD0853  [8]
 LDCM0256  AC137 HEK-293T C345(0.60); C449(1.31)  LDD0854  [8]
 LDCM0257  AC138 HEK-293T C345(0.69); C449(0.99)  LDD0855  [8]
 LDCM0258  AC139 HEK-293T C345(0.58); C449(0.69)  LDD0856  [8]
 LDCM0259  AC14 HCT 116 C345(0.71); C449(0.74)  LDD0576  [8]
 LDCM0260  AC140 HEK-293T C345(0.67); C449(1.19)  LDD0858  [8]
 LDCM0261  AC141 HEK-293T C345(0.75); C449(1.26)  LDD0859  [8]
 LDCM0262  AC142 HEK-293T C345(0.64); C449(1.15)  LDD0860  [8]
 LDCM0263  AC143 HCT 116 C345(0.74); C449(0.86)  LDD0580  [8]
 LDCM0264  AC144 HCT 116 C449(0.59); C345(0.87)  LDD0581  [8]
 LDCM0265  AC145 HCT 116 C449(0.75); C345(0.78)  LDD0582  [8]
 LDCM0266  AC146 HCT 116 C345(0.59); C449(0.63)  LDD0583  [8]
 LDCM0267  AC147 HCT 116 C449(0.65); C345(0.86)  LDD0584  [8]
 LDCM0268  AC148 HCT 116 C449(0.52); C345(0.62)  LDD0585  [8]
 LDCM0269  AC149 HCT 116 C449(0.54); C345(0.58)  LDD0586  [8]
 LDCM0270  AC15 HCT 116 C449(0.75); C345(0.76)  LDD0587  [8]
 LDCM0271  AC150 HCT 116 C449(0.74); C345(0.75)  LDD0588  [8]
 LDCM0272  AC151 HCT 116 C345(0.77); C449(0.91)  LDD0589  [8]
 LDCM0273  AC152 HCT 116 C449(0.52); C345(0.74)  LDD0590  [8]
 LDCM0274  AC153 HCT 116 C449(0.51); C345(0.57)  LDD0591  [8]
 LDCM0621  AC154 HCT 116 C345(0.75); C449(0.59)  LDD2158  [8]
 LDCM0622  AC155 HCT 116 C345(0.65); C449(0.55)  LDD2159  [8]
 LDCM0623  AC156 HCT 116 C345(0.68); C449(0.91)  LDD2160  [8]
 LDCM0624  AC157 HCT 116 C345(0.72); C449(0.94)  LDD2161  [8]
 LDCM0276  AC17 HCT 116 C449(1.04); C345(1.13)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C345(0.85); C449(1.24)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C345(0.98); C449(1.19)  LDD0595  [8]
 LDCM0279  AC2 HCT 116 C345(0.99); C449(1.25)  LDD0596  [8]
 LDCM0280  AC20 HCT 116 C449(1.00); C345(1.09)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C449(0.92); C345(1.01)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C449(1.02); C345(1.08)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C345(1.19); C449(1.32)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C449(1.03); C345(1.15)  LDD0601  [8]
 LDCM0285  AC25 HCT 116 C449(0.81); C345(0.89)  LDD0602  [8]
 LDCM0286  AC26 HCT 116 C449(0.75); C345(0.76)  LDD0603  [8]
 LDCM0287  AC27 HCT 116 C345(0.67); C449(0.76)  LDD0604  [8]
 LDCM0288  AC28 HCT 116 C449(0.72); C345(0.75)  LDD0605  [8]
 LDCM0289  AC29 HCT 116 C345(0.66); C449(0.75)  LDD0606  [8]
 LDCM0290  AC3 HCT 116 C449(0.96); C345(1.11)  LDD0607  [8]
 LDCM0291  AC30 HCT 116 C345(0.65); C449(0.69)  LDD0608  [8]
 LDCM0292  AC31 HCT 116 C345(0.65); C449(0.72)  LDD0609  [8]
 LDCM0293  AC32 HCT 116 C345(0.54); C449(0.59)  LDD0610  [8]
 LDCM0294  AC33 HCT 116 C345(0.56); C449(0.65)  LDD0611  [8]
 LDCM0295  AC34 HCT 116 C345(0.56); C449(0.60)  LDD0612  [8]
 LDCM0296  AC35 HCT 116 C345(1.30); C449(1.62)  LDD0613  [8]
 LDCM0297  AC36 HCT 116 C345(1.05); C449(1.26)  LDD0614  [8]
 LDCM0298  AC37 HCT 116 C345(1.06); C449(1.25)  LDD0615  [8]
 LDCM0299  AC38 HCT 116 C449(1.09); C345(1.14)  LDD0616  [8]
 LDCM0300  AC39 HCT 116 C449(1.09); C345(1.11)  LDD0617  [8]
 LDCM0301  AC4 HCT 116 C449(0.72); C345(1.06)  LDD0618  [8]
 LDCM0302  AC40 HCT 116 C449(0.85); C345(0.87)  LDD0619  [8]
 LDCM0303  AC41 HCT 116 C345(0.89); C449(1.32)  LDD0620  [8]
 LDCM0304  AC42 HCT 116 C345(0.91); C449(0.93)  LDD0621  [8]
 LDCM0305  AC43 HCT 116 C345(0.82); C449(1.18)  LDD0622  [8]
 LDCM0306  AC44 HCT 116 C345(0.81); C449(0.94)  LDD0623  [8]
 LDCM0307  AC45 HCT 116 C345(0.69); C449(0.80)  LDD0624  [8]
 LDCM0308  AC46 HCT 116 C345(0.93); C449(1.06)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C449(0.91); C345(1.06)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C345(0.88); C449(0.95)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C345(0.66); C449(0.81)  LDD0628  [8]
 LDCM0312  AC5 HCT 116 C449(0.71); C345(1.15)  LDD0629  [8]
 LDCM0313  AC50 HCT 116 C345(0.67); C449(0.77)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C345(1.28); C449(1.38)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C449(0.95); C345(1.01)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C345(0.77); C449(0.80)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C449(0.82); C345(0.83)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C345(0.74); C449(0.87)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C345(0.67); C449(0.84)  LDD0636  [8]
 LDCM0320  AC57 HCT 116 C449(0.67); C345(0.70)  LDD0637  [8]
 LDCM0321  AC58 HCT 116 C449(0.66); C345(0.76)  LDD0638  [8]
 LDCM0322  AC59 HCT 116 C345(0.52); C449(0.53)  LDD0639  [8]
 LDCM0323  AC6 HCT 116 C345(0.75); C449(0.77)  LDD0640  [8]
 LDCM0324  AC60 HCT 116 C345(0.48); C449(0.55)  LDD0641  [8]
 LDCM0325  AC61 HCT 116 C449(0.59); C345(0.62)  LDD0642  [8]
 LDCM0326  AC62 HCT 116 C449(0.52); C345(0.56)  LDD0643  [8]
 LDCM0327  AC63 HCT 116 C449(0.58); C345(0.63)  LDD0644  [8]
 LDCM0328  AC64 HCT 116 C345(0.53); C449(0.58)  LDD0645  [8]
 LDCM0329  AC65 HCT 116 C449(0.62); C345(0.77)  LDD0646  [8]
 LDCM0330  AC66 HCT 116 C449(0.66); C345(0.68)  LDD0647  [8]
 LDCM0331  AC67 HCT 116 C345(0.48); C449(0.59)  LDD0648  [8]
 LDCM0332  AC68 HCT 116 C449(0.76); C345(0.92)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C449(0.82); C345(0.98)  LDD0650  [8]
 LDCM0334  AC7 HCT 116 C345(0.82); C449(1.08)  LDD0651  [8]
 LDCM0335  AC70 HCT 116 C449(0.72); C345(1.04)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C449(1.00); C345(1.06)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C449(0.85); C345(1.00)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C345(0.93); C449(0.94)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C449(0.87); C345(1.12)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C345(0.89); C449(0.94)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C449(0.80); C345(1.19)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C449(0.79); C345(1.19)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C449(0.86); C345(1.13)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C345(0.94); C449(0.94)  LDD0661  [8]
 LDCM0345  AC8 HCT 116 C345(0.80); C449(0.84)  LDD0662  [8]
 LDCM0346  AC80 HCT 116 C449(0.82); C345(0.95)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C345(0.98); C449(1.12)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C449(0.99); C345(1.19)  LDD0665  [8]
 LDCM0349  AC83 HCT 116 C345(0.78); C449(1.82)  LDD0666  [8]
 LDCM0350  AC84 HCT 116 C345(0.79); C449(1.49)  LDD0667  [8]
 LDCM0351  AC85 HCT 116 C345(0.76); C449(1.37)  LDD0668  [8]
 LDCM0352  AC86 HCT 116 C345(0.79); C449(1.22)  LDD0669  [8]
 LDCM0353  AC87 HCT 116 C345(1.11); C449(1.54)  LDD0670  [8]
 LDCM0354  AC88 HCT 116 C345(0.85); C449(1.35)  LDD0671  [8]
 LDCM0355  AC89 HCT 116 C345(0.73); C449(1.30)  LDD0672  [8]
 LDCM0357  AC90 HCT 116 C345(0.76); C449(1.37)  LDD0674  [8]
 LDCM0358  AC91 HCT 116 C345(0.76); C449(1.14)  LDD0675  [8]
 LDCM0359  AC92 HCT 116 C345(0.79); C449(1.69)  LDD0676  [8]
 LDCM0360  AC93 HCT 116 C345(0.79); C449(1.19)  LDD0677  [8]
 LDCM0361  AC94 HCT 116 C345(1.03); C449(1.29)  LDD0678  [8]
 LDCM0362  AC95 HCT 116 C345(0.81); C449(1.30)  LDD0679  [8]
 LDCM0363  AC96 HCT 116 C345(0.93); C449(1.29)  LDD0680  [8]
 LDCM0364  AC97 HCT 116 C345(0.66); C449(1.03)  LDD0681  [8]
 LDCM0365  AC98 HCT 116 C345(0.53); C449(1.05)  LDD0682  [8]
 LDCM0366  AC99 HCT 116 C345(0.79); C449(1.03)  LDD0683  [8]
 LDCM0248  AKOS034007472 HCT 116 C345(0.98); C449(0.96)  LDD0565  [8]
 LDCM0356  AKOS034007680 HCT 116 C345(0.78); C449(0.85)  LDD0673  [8]
 LDCM0275  AKOS034007705 HCT 116 C449(0.61); C345(0.64)  LDD0592  [8]
 LDCM0498  BS-3668 MDA-MB-231 C337(0.52)  LDD2091  [5]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [16]
 LDCM0367  CL1 HCT 116 C345(0.95); C449(1.53)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C345(0.66); C449(1.37)  LDD0685  [8]
 LDCM0369  CL100 HCT 116 C449(0.77); C345(1.31)  LDD0686  [8]
 LDCM0370  CL101 HCT 116 C345(0.75); C449(0.85)  LDD0687  [8]
 LDCM0371  CL102 HCT 116 C345(0.89); C449(1.15)  LDD0688  [8]
 LDCM0372  CL103 HCT 116 C345(0.86); C449(1.30)  LDD0689  [8]
 LDCM0373  CL104 HCT 116 C345(0.81); C449(1.01)  LDD0690  [8]
 LDCM0374  CL105 HCT 116 C345(0.92); C449(1.33)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C345(0.80); C449(1.44)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C345(0.85); C449(1.05)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C345(0.85); C449(1.05)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C345(0.88); C449(1.13)  LDD0695  [8]
 LDCM0379  CL11 HCT 116 C345(0.63); C449(0.98)  LDD0696  [8]
 LDCM0380  CL110 HCT 116 C345(0.84); C449(1.65)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C345(0.90); C449(1.11)  LDD0698  [8]
 LDCM0382  CL112 HCT 116 C345(0.72); C449(0.97)  LDD0699  [8]
 LDCM0383  CL113 HCT 116 C345(0.61); C449(0.64)  LDD0700  [8]
 LDCM0384  CL114 HCT 116 C345(0.65); C449(1.05)  LDD0701  [8]
 LDCM0385  CL115 HCT 116 C345(0.67); C449(0.84)  LDD0702  [8]
 LDCM0386  CL116 HCT 116 C345(0.69); C449(0.72)  LDD0703  [8]
 LDCM0387  CL117 HCT 116 C345(0.75); C449(1.02)  LDD0704  [8]
 LDCM0388  CL118 HCT 116 C345(0.82); C449(0.95)  LDD0705  [8]
 LDCM0389  CL119 HCT 116 C345(0.78); C449(0.96)  LDD0706  [8]
 LDCM0390  CL12 HCT 116 C345(0.67); C449(0.74)  LDD0707  [8]
 LDCM0391  CL120 HCT 116 C345(1.10); C449(1.17)  LDD0708  [8]
 LDCM0392  CL121 HCT 116 C449(0.59); C345(0.74)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C345(0.69); C449(1.28)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C345(0.66); C449(1.72)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C345(0.73); C449(0.95)  LDD0712  [8]
 LDCM0396  CL125 HCT 116 C449(0.83); C345(0.95)  LDD0713  [8]
 LDCM0397  CL126 HCT 116 C345(0.71); C449(1.41)  LDD0714  [8]
 LDCM0398  CL127 HCT 116 C345(0.70); C449(0.70)  LDD0715  [8]
 LDCM0399  CL128 HCT 116 C449(0.64); C345(0.72)  LDD0716  [8]
 LDCM0400  CL13 HCT 116 C345(0.68); C449(0.80)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C345(0.83); C449(1.05)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C345(0.80); C449(1.28)  LDD0719  [8]
 LDCM0403  CL16 HCT 116 C345(0.78); C449(0.83)  LDD0720  [8]
 LDCM0404  CL17 HCT 116 C345(0.61); C449(1.37)  LDD0721  [8]
 LDCM0405  CL18 HCT 116 C345(0.56); C449(0.68)  LDD0722  [8]
 LDCM0406  CL19 HCT 116 C345(0.63); C449(0.84)  LDD0723  [8]
 LDCM0407  CL2 HCT 116 C345(1.01); C449(1.25)  LDD0724  [8]
 LDCM0408  CL20 HCT 116 C345(0.57); C449(0.81)  LDD0725  [8]
 LDCM0409  CL21 HCT 116 C345(0.54); C449(1.13)  LDD0726  [8]
 LDCM0410  CL22 HCT 116 C345(0.52); C449(0.89)  LDD0727  [8]
 LDCM0411  CL23 HCT 116 C449(0.68); C345(0.69)  LDD0728  [8]
 LDCM0412  CL24 HCT 116 C345(0.50); C449(0.67)  LDD0729  [8]
 LDCM0413  CL25 HCT 116 C345(0.54); C449(0.80)  LDD0730  [8]
 LDCM0414  CL26 HCT 116 C345(0.65); C449(0.71)  LDD0731  [8]
 LDCM0415  CL27 HCT 116 C345(0.68); C449(0.81)  LDD0732  [8]
 LDCM0416  CL28 HCT 116 C345(0.52); C449(0.74)  LDD0733  [8]
 LDCM0417  CL29 HCT 116 C345(0.59); C449(0.75)  LDD0734  [8]
 LDCM0418  CL3 HCT 116 C345(0.96); C449(1.61)  LDD0735  [8]
 LDCM0419  CL30 HCT 116 C345(0.72); C449(0.89)  LDD0736  [8]
 LDCM0420  CL31 HCT 116 C345(1.11); C449(1.46)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C345(1.06); C449(0.73)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C345(0.92); C449(1.26)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C345(0.83); C449(0.89)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C345(0.81); C449(0.67)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C345(0.89); C449(0.87)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C345(0.99); C449(0.82)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C345(1.09); C449(0.87)  LDD0745  [8]
 LDCM0429  CL4 HCT 116 C345(0.66); C449(1.64)  LDD0746  [8]
 LDCM0430  CL40 HCT 116 C345(1.04); C449(1.01)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C345(1.00); C449(0.80)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C345(1.04); C449(0.83)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C345(1.27); C449(0.77)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C345(1.20); C449(0.82)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C345(1.07); C449(0.98)  LDD0752  [8]
 LDCM0436  CL46 HCT 116 C345(1.17); C449(0.86)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C345(1.27); C449(0.90)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C345(1.34); C449(1.24)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C345(1.04); C449(1.08)  LDD0756  [8]
 LDCM0440  CL5 HCT 116 C345(0.89); C449(0.89)  LDD0757  [8]
 LDCM0441  CL50 HCT 116 C345(1.12); C449(0.99)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C345(1.54); C449(1.14)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C345(1.18); C449(0.97)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C345(1.18); C449(1.27)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C345(1.12); C449(1.24)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C345(1.31); C449(0.97)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C345(1.10); C449(0.88)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C345(1.09); C449(1.07)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C345(1.28); C449(0.82)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C345(1.27); C449(1.04)  LDD0767  [8]
 LDCM0451  CL6 HCT 116 C345(0.71); C449(1.09)  LDD0768  [8]
 LDCM0452  CL60 HCT 116 C345(1.05); C449(0.99)  LDD0769  [8]
 LDCM0453  CL61 HCT 116 C345(0.70); C449(0.93)  LDD0770  [8]
 LDCM0454  CL62 HCT 116 C345(0.86); C449(0.98)  LDD0771  [8]
 LDCM0455  CL63 HCT 116 C345(0.73); C449(1.07)  LDD0772  [8]
 LDCM0456  CL64 HCT 116 C345(0.58); C449(1.09)  LDD0773  [8]
 LDCM0457  CL65 HCT 116 C345(0.78); C449(0.94)  LDD0774  [8]
 LDCM0458  CL66 HCT 116 C345(0.57); C449(0.70)  LDD0775  [8]
 LDCM0459  CL67 HCT 116 C345(0.63); C449(0.71)  LDD0776  [8]
 LDCM0460  CL68 HCT 116 C345(0.52); C449(0.97)  LDD0777  [8]
 LDCM0461  CL69 HCT 116 C345(0.49); C449(0.96)  LDD0778  [8]
 LDCM0462  CL7 HCT 116 C345(0.74); C449(1.02)  LDD0779  [8]
 LDCM0463  CL70 HCT 116 C345(0.60); C449(0.89)  LDD0780  [8]
 LDCM0464  CL71 HCT 116 C345(0.71); C449(0.85)  LDD0781  [8]
 LDCM0465  CL72 HCT 116 C345(0.85); C449(0.89)  LDD0782  [8]
 LDCM0466  CL73 HCT 116 C345(0.63); C449(1.15)  LDD0783  [8]
 LDCM0467  CL74 HCT 116 C345(0.62); C449(0.78)  LDD0784  [8]
 LDCM0469  CL76 HCT 116 C345(0.85); C449(0.68)  LDD0786  [8]
 LDCM0470  CL77 HCT 116 C345(0.87); C449(1.27)  LDD0787  [8]
 LDCM0471  CL78 HCT 116 C345(1.01); C449(0.64)  LDD0788  [8]
 LDCM0472  CL79 HCT 116 C345(0.83); C449(0.44)  LDD0789  [8]
 LDCM0473  CL8 HCT 116 C345(0.70); C449(1.04)  LDD0790  [8]
 LDCM0474  CL80 HCT 116 C345(0.83); C449(0.61)  LDD0791  [8]
 LDCM0475  CL81 HCT 116 C345(0.97); C449(0.67)  LDD0792  [8]
 LDCM0476  CL82 HCT 116 C345(0.79); C449(0.46)  LDD0793  [8]
 LDCM0477  CL83 HCT 116 C345(0.67); C449(0.76)  LDD0794  [8]
 LDCM0478  CL84 HCT 116 C345(0.72); C449(0.74)  LDD0795  [8]
 LDCM0479  CL85 HCT 116 C345(0.79); C449(0.77)  LDD0796  [8]
 LDCM0480  CL86 HCT 116 C345(1.14); C449(0.95)  LDD0797  [8]
 LDCM0481  CL87 HCT 116 C345(0.92); C449(0.64)  LDD0798  [8]
 LDCM0482  CL88 HCT 116 C345(0.74); C449(0.43)  LDD0799  [8]
 LDCM0483  CL89 HCT 116 C345(0.92); C449(0.62)  LDD0800  [8]
 LDCM0484  CL9 HCT 116 C345(0.59); C449(0.90)  LDD0801  [8]
 LDCM0485  CL90 HCT 116 C345(0.90); C449(2.39)  LDD0802  [8]
 LDCM0486  CL91 HCT 116 C345(0.97); C449(0.87)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C345(1.01); C449(1.41)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C345(1.11); C449(1.41)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C345(1.23); C449(0.77)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C345(1.02); C449(1.08)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C345(0.96); C449(1.03)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C345(0.89); C449(0.84)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C345(1.07); C449(0.87)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C345(1.07); C449(0.69)  LDD0811  [8]
 LDCM0189  Compound 16 HEK-293T 16.95  LDD0492  [18]
 LDCM0185  Compound 17 HEK-293T 11.43  LDD0504  [18]
 LDCM0182  Compound 18 HEK-293T 4.54  LDD0501  [18]
 LDCM0184  Compound 20 HEK-293T 11.98  LDD0503  [18]
 LDCM0191  Compound 21 HEK-293T 6.23  LDD0493  [18]
 LDCM0186  Compound 31 HEK-293T 6.19  LDD0506  [18]
 LDCM0187  Compound 32 HEK-293T 9.66  LDD0507  [18]
 LDCM0188  Compound 33 HEK-293T 7.60  LDD0505  [18]
 LDCM0190  Compound 34 HEK-293T 36.36  LDD0497  [18]
 LDCM0192  Compound 35 HEK-293T 11.76  LDD0491  [18]
 LDCM0193  Compound 36 HEK-293T 11.56  LDD0494  [18]
 LDCM0194  Compound 37 HEK-293T 10.58  LDD0498  [18]
 LDCM0195  Compound 38 HEK-293T 17.09  LDD0499  [18]
 LDCM0196  Compound 39 HEK-293T 8.51  LDD0496  [18]
 LDCM0197  Compound 40 HEK-293T 11.98  LDD0495  [18]
 LDCM0181  Compound 41 HEK-293T 6.60  LDD0502  [18]
 LDCM0495  E2913 HEK-293T C351(0.90); C408(0.89)  LDD1698  [23]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C337(3.76)  LDD1702  [5]
 LDCM0575  Fragment13 Ramos C408(2.07)  LDD2192  [24]
 LDCM0580  Fragment21 Ramos C408(2.16)  LDD2195  [24]
 LDCM0578  Fragment27 Ramos C408(1.48)  LDD2197  [24]
 LDCM0586  Fragment28 Ramos C408(1.84)  LDD2198  [24]
 LDCM0589  Fragment31 Ramos C408(1.60)  LDD2200  [24]
 LDCM0468  Fragment33 HCT 116 C345(0.56); C449(0.82)  LDD0785  [8]
 LDCM0427  Fragment51 HCT 116 C345(0.91); C449(1.17)  LDD0744  [8]
 LDCM0022  KB02 HEK-293T C408(0.90); C351(0.94)  LDD1492  [23]
 LDCM0023  KB03 HEK-293T C408(1.02); C351(1.02)  LDD1497  [23]
 LDCM0024  KB05 G361 C449(2.36); C345(1.62)  LDD3311  [25]
 LDCM0109  NEM HeLa N.A.  LDD0230  [16]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C337(1.11)  LDD2093  [5]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C366(1.01); C337(0.99)  LDD2099  [5]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C366(0.85)  LDD2101  [5]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C366(0.53)  LDD2104  [5]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C337(1.36)  LDD2105  [5]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C366(0.40)  LDD2106  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C366(1.28); C337(1.03)  LDD2107  [5]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C366(0.73)  LDD2108  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C366(0.71); C337(0.84)  LDD2109  [5]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C337(0.89)  LDD2111  [5]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C366(0.49)  LDD2114  [5]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C337(1.28)  LDD2119  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C337(0.91)  LDD2123  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C366(0.89); C337(0.79)  LDD2125  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C366(1.01)  LDD2127  [5]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C366(1.21); C337(1.05)  LDD2129  [5]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C366(1.79); C337(1.05)  LDD2135  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C337(0.96)  LDD2136  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C366(1.03)  LDD2137  [5]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C337(1.56)  LDD1700  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C366(0.78); C337(0.87)  LDD2140  [5]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C366(0.71)  LDD2141  [5]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C337(1.47)  LDD2144  [5]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C366(1.01)  LDD2146  [5]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C337(1.25)  LDD2151  [5]
 LDCM0014  Panhematin HEK-293T 3.16  LDD0062  [7]
 LDCM0099  Phenelzine HEK-293T 6.00  LDD0390  [1]
 LDCM0084  Ro 48-8071 A-549 2.01  LDD0145  [20]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Itraconazole Small molecular drug DB01167
Miconazole Small molecular drug DB01110
Tioconazole Small molecular drug DB01007
Levoketoconazole . DB05667
Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Vt-1129 . D0UA9J
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
(S)-econazole . DB07705

References

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Mass spectrometry data entry: PXD028270
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
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Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
11 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
15 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
16 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
17 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
18 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
19 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
20 A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. doi: 10.1016/j.cell.2015.05.045.
21 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652
22 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
23 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
24 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
25 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840